“unlocking tomorrow’s cures”...ds 11 76 ajv sanlva santvn q £ 6 jvlnîn( dla (puny u:...

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Migraine & CGRP: a new era for patients Author: Prof Jan Versijpt, MD PhD Date: May 24, 2018 “Unlocking Tomorrow’s Cures”

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Page 1: “Unlocking Tomorrow’s Cures”...dS 11 76 aJV sanlVA santvn q £ 6 JVlnîn( dlA (puny u: Clinical trials begin to test telcagepant and other gepants in acute migraine Overview

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Migraine & CGRP: a new era for patientsAuthor: Prof Jan Versijpt, MD PhD Date: May 24, 2018

“Unlocking Tomorrow’s Cures”

Page 2: “Unlocking Tomorrow’s Cures”...dS 11 76 aJV sanlVA santvn q £ 6 JVlnîn( dlA (puny u: Clinical trials begin to test telcagepant and other gepants in acute migraine Overview
Page 3: “Unlocking Tomorrow’s Cures”...dS 11 76 aJV sanlVA santvn q £ 6 JVlnîn( dlA (puny u: Clinical trials begin to test telcagepant and other gepants in acute migraine Overview

Stovner, IHC 2009

Page 4: “Unlocking Tomorrow’s Cures”...dS 11 76 aJV sanlVA santvn q £ 6 JVlnîn( dlA (puny u: Clinical trials begin to test telcagepant and other gepants in acute migraine Overview

A) n 5

B) 4 - 72 h

C) 1.

2.

3. ++ / +++

4.

1. +

2.

2/4

1/2

D)

Page 5: “Unlocking Tomorrow’s Cures”...dS 11 76 aJV sanlVA santvn q £ 6 JVlnîn( dlA (puny u: Clinical trials begin to test telcagepant and other gepants in acute migraine Overview
Page 6: “Unlocking Tomorrow’s Cures”...dS 11 76 aJV sanlVA santvn q £ 6 JVlnîn( dlA (puny u: Clinical trials begin to test telcagepant and other gepants in acute migraine Overview

4

5

6

7Severe migraine

Active psychosis

Dementia

Quadriplegia

Unipolar major depression

Blindness

Paraplegia

Mild mental retardation

Down syndrome

Incr

eas

ing

dis

abili

ty

Below-the-knee amputation

Deafness

Menken M. Arch Neurol. 2000;57:418-420.

Disability Class 4

Disability Class 5

Disability Class 6

Disability Class 7

Page 7: “Unlocking Tomorrow’s Cures”...dS 11 76 aJV sanlVA santvn q £ 6 JVlnîn( dlA (puny u: Clinical trials begin to test telcagepant and other gepants in acute migraine Overview
Page 8: “Unlocking Tomorrow’s Cures”...dS 11 76 aJV sanlVA santvn q £ 6 JVlnîn( dlA (puny u: Clinical trials begin to test telcagepant and other gepants in acute migraine Overview
Page 9: “Unlocking Tomorrow’s Cures”...dS 11 76 aJV sanlVA santvn q £ 6 JVlnîn( dlA (puny u: Clinical trials begin to test telcagepant and other gepants in acute migraine Overview
Page 10: “Unlocking Tomorrow’s Cures”...dS 11 76 aJV sanlVA santvn q £ 6 JVlnîn( dlA (puny u: Clinical trials begin to test telcagepant and other gepants in acute migraine Overview

Ann Neurol 1990;28(2):183-7Brain 1994;117( Pt 3):427-34

Page 11: “Unlocking Tomorrow’s Cures”...dS 11 76 aJV sanlVA santvn q £ 6 JVlnîn( dlA (puny u: Clinical trials begin to test telcagepant and other gepants in acute migraine Overview
Page 12: “Unlocking Tomorrow’s Cures”...dS 11 76 aJV sanlVA santvn q £ 6 JVlnîn( dlA (puny u: Clinical trials begin to test telcagepant and other gepants in acute migraine Overview
Page 13: “Unlocking Tomorrow’s Cures”...dS 11 76 aJV sanlVA santvn q £ 6 JVlnîn( dlA (puny u: Clinical trials begin to test telcagepant and other gepants in acute migraine Overview

EfficacyShort-term safety / tolerance

SuperiorityEfficacy in treatment-refractory patients

Long-term safety

Page 14: “Unlocking Tomorrow’s Cures”...dS 11 76 aJV sanlVA santvn q £ 6 JVlnîn( dlA (puny u: Clinical trials begin to test telcagepant and other gepants in acute migraine Overview

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Q&A

THANK YOU!