“So the Lord God caused a deep sleep to fall upon theman, and while he slept took one of his ribs and closedup its place with flesh; and the rib which the Lord Godhad taken from the man he made into a woman andbrought her to the man”.

Genesis 2.1

The evidence that stem cells can multiply indefinitely in cultures and transform

into different tissues has raised hopes that their use could be curative.

Tissue regeneration using different stem cells in the experimental laboratory

has advanced enormously. However, the application of progenitor cells in clinical trials

has been limited almost exclusively to cardiovascular diseases. This has been possible

because the classical dogma denying cardiac regenerative capacity of heart muscle has

been overcome. Furthermore, there is an increasing amount of data indicating that it is

possible to encourage the regenerative capacity of the myocardium by stimulating resident

stem cells or transplanting extracardiac progenitors able to transform into functioning

cardiocytes. Finally the results of clinical trials based on these findings are extremely

promising.

These advances have awakened increasing interest among those working on

the study of cardiovascular diseases and in the care of patients suffering from this

pathology. This First International Symposium on Stem Cell Therapy for Cardiovascular

Diseases has been designed to stimulate an exhaustive discussion about the fact and

fantasy of this new field. With this aim, clinical and basic scientists will discuss, from

the stage or from the audience, the latest advances in experimental and clinical

cardiovascular stem cell research. Moreover, this new therapeutic mode will be put into

perspective with a view to making a realistic assessment of its future. Finally, there will

be a debate on the implantation of regenerative medicine within the Spanish Health

Service.

Everyone who has contributed to the design of this program believes that

there should be an active and continuous forum for debate on the cardiovascular

application of stem cell therapy. Therefore, we intend to contribute to this through

the annual celebration of this event. For the same reason, we have created a virtual

platform to maintain an active discussion on this topic until the next year

(www.terapiacelularcardiaca.com).

We hope to fulfil the expectations of all those who have agreed to come to Valladolid

and take part in the meeting. We look forward to sharing this day with you.

The Organization Committee

PROGRAMA

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6INDEX

ORGANIZATION

FACULTY

SCIENTIFIC PROGRAM

GENERAL INFORMATION

HOSTING AND TRANSPORTATION

COLLABORATORS

DIRECTORCO-DIRECTORSACREDITATIONSORGANIZATIONSCIENTIFIC COMITTEE

MEETING VENUEDATEORGANIZATIONWEBTECHNICAL SECRETARIATOFFICIAL LANGUAGES

MAIN SPONSORSOTHER GRANTS

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Director

Francisco F. AvilésDirector of the Institute of Heart Sciences (ICICOR)from the University Hospital of Valladolid

Co-directors

Luis de la Fuente GalánICICOR. University Hospital of Valladolid

Javier García FradeDepartment of Hemathology. Hospital Río Hortega

Alberto San Román CalvarICICOR. University Hospital of Valladolid

Ana SánchezInstitute of Biology and Molecular Genetics (IBGM)

ORGANIZATION

Accreditation

Continuing Medical Education Accreditation of theSpanish Society of Cardiology.EBAC (European Board for Accreditation in Cardiology).Sociosanitary Recognized Activity by the Castillaand León Government.

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Organization

Institute of Heart Sciences (ICICOR) from the UniversityHospital of Valladolid.

Cooperative Network for Cardiovascular Research of theCarlos III National Health Institute.

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Scientific Committee

Juan Manuel DuránInstitute of Heart Sciences (ICICOR) from the University Hospital of Valladolid.

Elena Fernández FontechaInstitute of Heart Sciences (ICICOR) from the University Hospital of Valladolid.

Ma Eugenia Fernández SantosInstitute of Biology and Molecular Genetics. IBGM

Javier García-SanchoInstitute of Biology and Molecular Genetics. IBGM

Federico GimenoInstitute of Heart Sciences (ICICOR) from the University Hospital of Valladolid.

Manuel Gómez BuenoInstitute of Heart Sciences (ICICOR) from the University Hospital of Valladolid.

Carolina HernándezInstitute of Heart Sciences (ICICOR) from the University Hospital of Valladolid.

Javier LópezInstitute of Heart Sciences (ICICOR) from the University Hospital of Valladolid.

Pedro MotaInstitute of Heart Sciences (ICICOR) from the University Hospital of Valladolid.

Gonzalo PeñaInstitute of Heart Sciences (ICICOR) from the University Hospital of Valladolid.

Ma Jesús PeñarrubiaDepartment of Hemathology. Hospital Río Hortega

Benigno RamosInstitute of Heart Sciences (ICICOR) from the University Hospital of Valladolid.

Pedro Luis SánchezInstitute of Heart Sciences (ICICOR) from the University Hospital of Valladolid.

Ricardo SanzInstitute of Heart Sciences (ICICOR) from the University Hospital of Valladolid.

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Noel CapliceDepartment of CardiologyMayo ClinicRochester. USA

Alfonso Castro BeirasHospital Juan CanalejoA Coruña. Spain

Nabil DibArizona Heart InstitutePhoenix. USA

E. B. DiethrichArizona Heart InstitutePhoenix. USA

Francisco F. AvilésInstitute of Heart Sciences (ICICOR)University Hospital of ValladolidValladolid. Spain

Manuel GaliñanesDepartment of Integrative HumanCardiovascular Physiology and Functional GenomicsDivision of Cardiac SurgeryUniversity of Leicester - Glenfield HospitalLeicester. United Kingdom

David García-DoradoCardiovascular Research Laboratory(Department of Cardiology)Hospital Valle HebronBarcelona. Spain

FACULTY2

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Javier García FradeDepartment of HemathologyHospital Río HortegaValladolid. Spain

Izhak KehatCardiovascular Research LaboratoryBruce Rappaport Faculty of MedicineIsrael Institute of TechnologyTechnion. Israel

Annarosa LeriCardiovascular Research InstituteDepartment of MedicineNew York Medical CollegeNew York. USA

John MartinCentre for Cardiovascular Biology & MedicineBHF LaboratoriesLondon. United Kingdom

Rafael MatesanzNational centre of Cell Therapy and Regenerative MedicineMadrid. Spain

Bernardo NadalCardiovascular Research InstituteDepartment of MedicineNew York Medical CollegeNew York. USA

Emerson PerinTexas Heart InstituteHouston.Texas. USA

Noel CapliceDepartment of CardiologyMayo ClinicRochester. USA

Alfonso Castro BeirasHospital Juan CanalejoA Coruña. Spain

Nabil DibArizona Heart InstitutePhoenix. USA

E. B. DiethrichArizona Heart InstitutePhoenix. USA

Francisco F. AvilésInstitute of Heart Sciences (ICICOR)University Hospital of ValladolidValladolid. Spain

Manuel GaliñanesDepartment of Integrative HumanCardiovascular Physiology and Functional GenomicsDivision of Cardiac SurgeryUniversity of Leicester - Glenfield HospitalLeicester. United Kingdom

David García-DoradoCardiovascular Research Laboratory(Department of Cardiology)Hospital Valle HebronBarcelona. Spain

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Felipe ProsperDepartment of Hemathology and Cell Therapy AreaUniversity Clinic of NavarraPamplona. Spain

Alberto San RománInstitute of Heart Sciences (ICICOR)University Hospital of ValladolidValladolid. Spain

Ana SánchezInstitute of Biology and Molecular Genetics (IBGM)Faculty of Medicine. University of ValladolidValladolid. Spain

Jordi Soler SolerDepartment of CardiologyHospital Valle HebronBarcelona. Spain

Bodo StrauerDepartment of MedicineDivisión of CardiologyHeinrich-Heine UniversitaetDuesseldorf. Germany

FACULTY2

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9.30 OPENING SESSION

10.00 Conference:“MYOCARDIAL REGENERATION. OLD DOGMAS, NEW FACTS”

Chairpersons: Jordi Soler Soler (Barcelona, Spain)Speaker: Bernardo Nadal (New York, USA)

10.20 Discussion

10.30 Coffee break

11.00 Round Table: “BASIC APPROACHES TOCARDIAC REGENERATION”Chairpersons: Bernardo Nadal (New York, USA)

Ana Sánchez (Valladolid, Spain)

11.00 “Human embryonic stem cellderived cardiomyocytes”Izhak Kehat (Tel Aviv, Israel)

11.15 “Regeneration of the senescent heart”Annarosa Leri (New York, USA)

11.30 “Myocardial tissue integration and functionalityof transplanted myoblats”Nabil Dib (Arizona, USA)

11.45 “Transdifferentiation of implanted bonemarrow progenitors”Ana Sánchez (Valladolid, Spain)

12.00 “Skeletal myoblasts versus bone marrow stemcells for cardiac repair”Felipe Prósper (Pamplona, Spain)

12.15 Discussion

13.00 Lunch

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14.30 Round Table: “CLINICAL APPLICATION OF CELL THERAPY FOR

MYOCARDIAL REGENERATION”

Chairpersons: Alfonso Castro-Beiras (A Coruña, Spain)

David García-Dorado (Barcelona, Spain)

14.30 “Autologous skeletal myoblats transplantation as an adjunct

to bypass surgery”

Edward B. Diethrich (Phoenix, USA)

14.45 “Autotransplantation of bone marrow mononuclear cells into scarred

myocardium during cardiac surgery for the recovery of heart function”

Manuel Galiñanes (Leicester, UK)

15.00 “Percutaneous transplantation of bone marrow cells for chronic

ischemic heart failure”

Emerson Perin (Houston, USA)

15.15 “Extraction and processing of bone marrow progenitors for the repair

of acutely infarcted myocardium. Practical issues”

Javier García Frade (Valladolid, Spain)

15.30 “Intracoronary bone marrow stem cells transplantation after

the acute phase of myocardial infarction”

Bodo Strauer (Duesseldorf, Germany)

15.45 “Conventional post-reperfusion therapy versus intracoronary bone

marrow stem cell transplantation or mobilization after STEMI.

The TECAM randomised trial”

Francisco F. Avilés (Valladolid, Spain)

16.00 Discussion

16.15 Coffee break

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16.45 Controversy: “STEM CELL TRANSPLANTATION FOR CARDIAC

REPAIR IN PERSPECTIVE”

Chairpersons: John Martin (Londres, UK)

Alberto San Román (Valladolid, Spain)

16.45 “Hopes from the Researcher Perspective”

Bodo Strauer ( Duesseldorf, Germany)

17.05 “Concerns from the Clinician Perspective”

Noel Caplice (Rochester, USA)

17.25 Discussion

17.45 Closing conference: “STEM CELL THERAPY FOR MYOCARDIAL REPAIR

FROM THE INSTITUTIONAL POINT OF VIEW”

Chairperson: Francisco F. Avilés (Valladolid, SPAIN)

17.45 “Organization of stem cell therapy research and clinical activities

in the Spanish National Health Service”

Rafael Matesanz (Director of the National Centre

of Transplants and Regenerative Medicine)

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Meeting Venue

Teatro Calderón de la Barca(Salón de los Espejos)C/ Angustias 147001 Valladolid. Spain

GENERAL INFORMATION4

Organization

Institute of Heart Sciences (ICICOR) from the University Hospital

of Valladolid

Cooperative Network for Cardiovascular Research of the Carlos

III National Health Institute

Date

March, the 26th 2004

Scientific Secretariat

Ana Ma Fernández BazaTel: 00 34 983 42 00 26

Fax: 00 34 983 25 53 05E-mail: amfb@ole.com

Technical Secretariat

Viajes OrbiazulC/ Alonso Pesquera, 247002 ValladolidTel: 00 34 983 30 91 22Fax: 00 34 983 29 53 51E-mail: orbiazul@terra.es

Official languages

Spanish and English (Simultaneous translation will be available)

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Meeting Venue

Travel plan and accomodation will be individually arranged

for the participants.

Any additional information can be requested from

the Technical or Scientific Secretariat.

HOSTING AND ACCOMODATION5

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6Collaboration

Department of Hemathology. University Hospital Río Hortega

Institute of Biology and Molecular Genetics (IBGM)

Health Department of the Castilla and Leon Government

Education Department of the Castilla and Leon Government

University of Valladolid

TEAM Group ( Endovascular and Myocardial Therapy)

COLLABORATORS

6 COLLABORATORS

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Main Sponsors

Caja Duero

Johnson and Johnson. (Division Cordis)

Medtronic Ibérica

Lilly

Boeringher-Ingelheim

Dr. Esteve Laboratorios

Mercé V. Electromedicina

Guidant

Boston Scientific Ibérica

Cormedica

Biotronik

Izasa

Sorin Biomedica

This Symposium has been made

possible through unrestricted

educational grants provided by the

sponsors mentioned below

Sponsors

Amgen

Microflux

Astrazeneka

Cardiva

Other grants

Biomed

MSD