antimicrobial resistance complex issue
TRANSCRIPT
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SHIV VARAN SINGH
VBM(M.V.Sc)
M-5547
ANTIMICROBIAL RESISTANT:A COMLPEX ISSUE
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WHY RESISTANCE IS A CONCERN
• Resistant organisms lead to treatment failure
• Increased mortality
• Resistant bacteria may spread in Community
• Low level resistance can go undetected
• Added burden on healthcare costs
• Threatens to return to pre-antibiotic era
• Selection pressure
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ANTIMICROBIAL RESISTANCE MECHANISM
Intrinsic (Natural) Acquired
Genetic Methods
Chromosomal Methods Mutations
Extra chromosomal Methods Plasmids
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INTERACTION OF BACTERIAWITH ANTIBIOTICS
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ORIGIN OF ANTIMICROBIALRESISTANCE DETERMINANTS
Animal pathogen
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RESISTANCE TO ANANTIBIOTIC CAN BE ACQUIRED
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SELECTION OF A RESISTANTBACTERIAL POPULATION
• PRE-EXISTING SELECTION(RESISTOME)
• MUTANT ONE SELECTED(SUBSISTOME)
• CONCENTRATION BASIS
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DISSEMINATION OF BACTERIA
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EDUCATIONAL ACTIVITIES TO PROMOTE APPROPRIATE USE OF ANTIMICROBIAL AGENTS IN ANIMAL HEALTH
• Veterinary Curriculum
• State-based Interventions
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Strategy of ContainmentAntibiotic Resistance
Evolutionary Process
Faulty Use of Antibiotics
Hospital Environmental
Empirical Use Definitive Use
Community Acquired Antibiotic Resistance
Hospital Acquired Antibiotic Resistance
Use of antimicrobials before pathogen responsible for a particular illness or the susceptibility to a particular antimicrobial is known
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HOW THE COMPLEXITYOF THE RESISTANCE PROBLEM DEDUCED
Do not use Faulty Antimicrobial Antimicrobial warranted or not
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What are etiological agents? Definitive treatment
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One OR In combination What can we do?
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