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www.MedChemExpress.com 1 Inhibitors, Agonists, Screening Libraries www.MedChemExpress.com Antibody-drug Conjugate/ADC Related

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  • www.MedChemExpress.com 1

    Inhibitors, Agonists, Screening Librarieswww.MedChemExpress.com

    Antibody-drug Conjugate/ADC Related

    http://www.MedChemExpress.com

  • • ADC Cytotoxin 3

    • ADC Linker 8

    • Drug-Linker Conjugates for ADC 10

    Inhibitors, Agonists, Screening Librarieswww.MedChemExpress.com

    Target List in Antibody-drug Conjugate/ADC Related

    2 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

    http://www.MedChemExpress.com

  • www.MedChemExpress.com 3

    ADC Cytotoxin 

    A cytotoxin is any substance which has a toxic effect on cells. Somecommon examples of cytotoxins include chemical agents and certainsnake venoms. Cytotoxins typically attack only a specific type of cellor organ, rather than an entire body. Cells that have been affected bya cytotoxin can perish in several different ways. One is necrosis. In thisform of cell death, the cells lose integrity in their membrane wall andcollapse. Another type of possible cell death is apoptosis. This type ofdeath is pre-programmed into the cell itself before the cytotoxinarrives. It is typically a beneficial property, as seen when cells in thefingers and toes of developing human babies undergo apoptosis,leading to the separation of digits. Chemotherapy as a treatment of

    cancer often relies on the ability of these agents to preferentially kill or damage cancer cells as opposed to healthycells.

    http://www.medchemexpress.com/Targets/ADC Cytotoxin.html

  • Purity: 98.56%Clinical Data:Size: 10mM x 1mL in DMSO,

    5 mg, 10 mg

    Purity: >98%Clinical Data:Size: 10mM x 1mL in DMSO,

    1 mg, 5 mg, 10 mg

    Purity: 98.26%Clinical Data:Size: 10mM x 1mL in DMSO,

    100 mg, 500 mg

    Purity: 98.44%Clinical Data:Size: 10mM x 1mL in DMSO,

    1 mg, 5 mg, 10 mg

    Purity: 98.35%Clinical Data:Size: 10mM x 1mL in DMSO,

    1 mg, 5 mg, 10 mg

    Purity: 96.72%Clinical Data:Size: 10mM x 1mL in DMSO,

    1 mg, 5 mg, 10 mg

    Purity: 90.81%Clinical Data:Size: 10mM x 1mL in DMSO,

    5 mg, 10 mg, 50 mg, 100 mg

    Purity: >98%Clinical Data:Size: 10mM x 1mL in DMSO,

    5 mg, 10 mg, 50 mg, 100 mg

    Purity: 95.14%Clinical Data:Size: 1 mg, 5 mg

    Purity: 81.89%Clinical Data:Size: 10mM x 1mL in DMSO,

    10 mg, 50 mg

    ADC Cytotoxin Inhibitors & Modulators

    Bioactivity: 10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel derivative withimproved pharmacological features and higher water solubility.

    Bioactivity: alpha-Amanitin is the principal toxin of several deadly poisonousmushrooms, exerting its toxic function by inhibiting

    .RNA-polymerase II

    Bioactivity: Ansamitocin P 3' exhibits antitumour activity, is an antibody drugconjugate cytotoxin.

    Bioactivity: Ansamitocin P-3 is a inhibitor. Ansamitocin P-3 is amicrotubulemacrocyclic antitumor antibiotic.

    Bioactivity: Auristatin E is a cytotoxic tubulin modifier with potent and selectiveantitumor activity; MMAE analog and cytotoxin in Antibody-drugconjugates.

    Bioactivity: Auristatin F is a cytotoxic tubulin modifier with potent and selectiveantitumor activity; MMAF analog and cytotoxin in Antibody-drugconjugates.

    Bioactivity: Calicheamicin is a potent DNA-damaging cytotoxic agent. Bioactivity: Campathecin is a potent DNA enzyme topoisomerase I (topo I)inhibitor, with and of 50 nM and 0.225 μM in breast cancerIC50 IC70cell line MDA-MB-231.

    Bioactivity: D8-MMAE is a deuterated form of MMAE, which is a microtubule-disrupting agent.

    Bioactivity: Daun02 is converted by to Daunorubicin, which is a β-galactosidase inhibitor.topoisomerase

    4 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

    10-Deacetyl-7-xylosyl paclitaxel (10-Deacetyl-7-xylosyltaxol; 10-Deacetylpaclitaxel 7-Xyloside; 10-Deacetylt…) Cat. No.: HY-20584

    alpha-Amanitin(α-Amanitin; α-Amatoxin) Cat. No.: HY-19610

    Ansamitocin P 3'(Antibiotic C 15003P3'; Maytansinol butyrate) Cat. No.: HY-19839

    Ansamitocin P-3 (Antibiotic C 15003P3; Maytansinol butyrate; C15003P3) Cat. No.: HY-15739

    Auristatin ECat. No.: HY-15582

    Auristatin FCat. No.: HY-15583

    Calicheamicin(Calicheamicin γ1) Cat. No.: HY-19609

    Campathecin((S)-(+)-Camptothecin; CPT) Cat. No.: HY-16560

    D8-MMAE(D8-Monomethyl auristatin E; D8-Vedotin; D8 MMAE) Cat. No.: HY-15162A

    Daun02(Daun 02; Daun-02) Cat. No.: HY-13061

    http://www.medchemexpress.com/Targets/ADC Cytotoxin.htmlhttp://www.medchemexpress.com/10-deacetyl-7-xylosyl-paclitaxel.htmlhttp://www.medchemexpress.com/alpha-Amanitin.htmlhttp://www.medchemexpress.com/Ansamitocin-P-3_acute_.htmlhttp://www.medchemexpress.com/Ansamitocin-P-3.htmlhttp://www.medchemexpress.com/Auristatin-E.htmlhttp://www.medchemexpress.com/Auristatin-F.htmlhttp://www.medchemexpress.com/Calicheamicin.htmlhttp://www.medchemexpress.com/Campathecin.htmlhttp://www.medchemexpress.com/d8-mmae.htmlhttp://www.medchemexpress.com/daun02.html

  • www.MedChemExpress.com 5

    Purity: >98.00%Clinical Data: Phase 4Size: 10mM x 1mL in DMSO,

    5 mg, 10 mg, 50 mg, 100 mg

    Purity: 99.69%Clinical Data: Phase 4Size: 10mM x 1mL in DMSO,

    100 mg, 500 mg

    Purity: 99.03%Clinical Data:Size: 10mM x 1mL in DMSO,

    5 mg, 10 mg, 50 mg

    Purity: >95.0%Clinical Data: Phase 1, Phase 2Size: 5 mg, 10 mg, 50 mg, 100 mg

    Purity: 99.63%Clinical Data: Phase 4Size: 10mM x 1mL in DMSO,

    50 mg, 100 mg, 200 mg, 500 mg, 1 g

    Purity: >98%Clinical Data:Size: 50 mg, 100 mg, 200 mg, 500 mg

    Purity: >98%Clinical Data: Phase 1, Phase 2Size: 5 mg, 10 mg, 50 mg, 100 mg

    Purity: 98.44%Clinical Data:Size: 10mM x 1mL in DMSO,

    1 mg, 5 mg

    Purity: 99.64%Clinical Data: Phase 4Size: 10mM x 1mL in Water,

    10 mg, 50 mg, 100 mg, 200 mg, 500 mg

    Purity: >98%Clinical Data:Size: 10 mg, 50 mg

     

    Bioactivity: Daunorubicin(RP13057) inhibits both DNA and RNA synthesis andinhibits DNA synthesis with Ki of 0

    Bioactivity: Daunorubicin hydrochloride is a inhibitor.topoisomerase II

    Bioactivity: Dolastatin 10 is a potent antimitotic peptide, isolated from themarine mollusk , that inhibits Dolabela auricularia tubulinpolymerization.

    Bioactivity: DOXO-EMCH is a 6-maleimidocaproyl hydrazone derivative ofDoxorubicin, is an albumin binding prodrug.

    Bioactivity: Doxorubicin(Adriamycin) is an antibiotic agent that inhibits DNAtopoisomerase II and induces DNA damage and apoptosis

    Bioactivity: Topoisomerase IIDoxorubicin hydrochloride is a (Top2) catalyticinhibitor, also is a broad spectrum antibiotic used in the treatment ofcancers, with of 374 nM for Hela cells.IC50

    Bioactivity: INNO-206 is a prodrug of the anticancer agent doxorubicin, which isreleased from albumin under acidic conditions.

    Bioactivity: Maytansinol inhibits microtubule assembly and induces microtubuledisassembly in vitro.

    Bioactivity: Methotrexate is a traditional antagonist, with median offolate IC5078 nM for a 120 h drug exposure in a panel of six pediatric leukemiaand lymphoma cell lines using the sulforhodamine B assay.

    Bioactivity: Mitomycin C is a DNA-damaging agent and small-molecule inhibitoreffectively sensitize cancer cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL).

    Daunorubicin(RP13057; Daunomycin; Rubidomycin) Cat. No.: HY-13062A

    Daunorubicin Hydrochloride (RP 13057 Hydrochloride; Daunomycin; RP13057 Hydrochloride; RP-13057 Hydroc…) Cat. No.: HY-13062

    Dolastatin 10(DLS 10; NSC 376128; Dolastatin-10) Cat. No.: HY-15580

    DOXO-EMCH(Doxorubicin-EMCH) Cat. No.: HY-16261A

    Doxorubicin(Adriamycin; Hydroxydaunorubicin) Cat. No.: HY-15142A

    Doxorubicin hydrochloride(Adriamycin; Hydroxydaunorubicin hydrochloride) Cat. No.: HY-15142

    INNO-206(Aldoxorubicin; INNO 206; INNO206) Cat. No.: HY-16261

    Maytansinol(Ansamitocin P-0) Cat. No.: HY-19474

    Methotrexate(Amethopterin; CL14377; WR19039) Cat. No.: HY-14519

    Mitomycin C(Ametycine) Cat. No.: HY-13316

    http://www.medchemexpress.com/daunorubicin.htmlhttp://www.medchemexpress.com/Daunorubicin-Hydrochloride.htmlhttp://www.medchemexpress.com/Dolastatin-10.htmlhttp://www.medchemexpress.com/DOXO-EMCH.htmlhttp://www.medchemexpress.com/Doxorubicin.htmlhttp://www.medchemexpress.com/Doxorubicin-hydrochloride.htmlhttp://www.medchemexpress.com/INNO-206.htmlhttp://www.medchemexpress.com/Maytansinol.htmlhttp://www.medchemexpress.com/Methotrexate.htmlhttp://www.medchemexpress.com/Mitomycin-C.html

  • Purity: 99.97%Clinical Data:Size: 10mM x 1mL in DMSO,

    5 mg, 10 mg, 50 mg

    Purity: 96.84%Clinical Data:Size: 10mM x 1mL in DMSO,

    1 mg, 5 mg, 10 mg, 50 mg

    Purity: 99.68%Clinical Data:Size: 10mM x 1mL in DMSO,

    1 mg, 5 mg, 10 mg

    Purity: 99.51%Clinical Data: Phase 4Size: 10mM x 1mL in DMSO,

    50 mg, 100 mg, 500 mg

    Purity: 99.92%Clinical Data:Size: 10mM x 1mL in DMSO,

    1 mg, 5 mg, 10 mg, 50 mg, 100 mg

    Purity: >98%Clinical Data:Size: 10mM x 1mL in DMSO,

    2 mg, 5 mg, 10 mg

    Purity: 99.38%Clinical Data:Size: 10mM x 1mL in DMSO,

    2 mg, 5 mg, 10 mg

    Purity: >98%Clinical Data:Size: 2 mg, 5 mg, 10 mg

    Purity: 99.8%Clinical Data:Size: 10mM x 1mL in DMSO,

    10 mg, 50 mg, 100 mg

    Purity: 99.9%Clinical Data:Size: 10mM x 1mL in DMSO,

    5 mg, 10 mg, 50 mg, 100 mg

     

    Bioactivity: MMAD is a potent inhibitor, is a toxin payload in antibodytubulindrug conjugates ( ).ADCs

    Bioactivity: Monomethyl auristatin D Hcl (MMAD Hcl), a potent tubulin inhibitor,is a toxin payload in antibody drug conjugate.

    Bioactivity: MMAF is an antitubulin agent that inhibit cell division; inhibits H3397cell growth with an of 105 nM.IC50

    Bioactivity: MMAF hydrochloride is an antitubulin agent that inhibit cell division;inhibits H3397 cell growth with an of 105 nM.IC50

    Bioactivity: MMAF-Ome belongs to ADC, and inhibits several tumor cell lineswith s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM forIC50MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4 ) cell-

    lines, respectively.

    Bioactivity: Monomethyl auristatin E (MMAE) is an antimitotic agent whichinhibits cell division by blocking the polymerisation of , andtubulinalso shows inhibition of antibody-drug conjugates ( ) activity.ADCs

    Bioactivity: Paclitaxel is a potent anticancer agent known to promote  assembly, inhibit MT depolymerization, andmicrotubule (MT)

    change MT dynamics required for mitosis and cell proliferation.

    Bioactivity: PF-06380101 is a novel cytotoxic Dolastatin 10 analogue; withexcellent potencies in tumor cell proliferation assays and differentialADME properties when compared to other synthetic auristatinanalogues that are used in the preparation of ADCs.

    Bioactivity: PNU-159682 is a major bioactive metabolite of Nemorubicin inhuman liver microsomes; > 3,000-fold cytotoxic than its parentcompound(MMDX and doxorubicin).

    Bioactivity: Taltobulin (HTI-286; SPA-110) is an analogue of Hemiasterlin; potenttubulin inhibitor; ADCs cytotoxin.

    6 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

    MMAD (Demethyldolastatin 10; Monomethylauristatin D; Monomethyl Dolastatin 10) Cat. No.: HY-15581

    MMAD hydrochloride (Demethyldolastatin 10 hydrochloride; Monomethylauristatin D hydrochloride; Monomethyl …) Cat. No.: HY-79105

    MMAF(Monomethylauristatin F) Cat. No.: HY-15579

    MMAF Hydrochloride(Monomethylauristatin F Hydrochloride) Cat. No.: HY-15579A

    MMAF-OMe(Monomethyl auristatin F methyl ester) Cat. No.: HY-79256

    Monomethyl auristatin E(Vedotin; MMAE) Cat. No.: HY-15162

    PaclitaxelCat. No.: HY-B0015

    PF-06380101Cat. No.: HY-12522

    PNU-159682(PNU159682; PNU 159682) Cat. No.: HY-16700

    Taltobulin (HTI-286; SPA-110; HTI286;SPA110; HTI 286; SPA 110) Cat. No.: HY-15584

    http://www.medchemexpress.com/MMAD.htmlhttp://www.medchemexpress.com/MMAD-hydrochloride.htmlhttp://www.medchemexpress.com/mmaf.htmlhttp://www.medchemexpress.com/MMAF-Hydrochloride.htmlhttp://www.medchemexpress.com/MMAF-OMe.htmlhttp://www.medchemexpress.com/Monomethyl-auristatin-E.htmlhttp://www.medchemexpress.com/Paclitaxel.htmlhttp://www.medchemexpress.com/PF-06380101.htmlhttp://www.medchemexpress.com/pnu-159682.htmlhttp://www.medchemexpress.com/taltobulin.html

  • www.MedChemExpress.com 7

    Purity: >98%Clinical Data: Phase 1Size: 1 mg

    Purity: 99.83%Clinical Data: Phase 1, Phase 2Size: 10mM x 1mL in DMSO,

    2 mg, 5 mg, 10 mg, 25 mg, 100 mg

    Purity: 98.52%Clinical Data:Size: 10mM x 1mL in DMSO,

    5 mg, 10 mg, 50 mg

    Purity: >98%Clinical Data:Size: 10mM x 1mL in DMSO,

    5 mg, 10 mg, 50 mg

     

    Bioactivity: Taltobulin hydrochloride is an analogue of Hemiasterlin; potenttubulin inhibitor; ADCs cytotoxin.

    Bioactivity: Taltobulin trifluoroacetate (HTI-286; SPA-110) is an analogue ofHemiasterlin; potent tubulin inhibitor; ADCs cytotoxin.

    Bioactivity: Triptolide is an inhibitor of heat shock factor ( ), inhibitsHSF1HSP90-CDC37 binding and induces acetylation of HSP90, and alsoinhibits expression in a dose-dependent manner with MDM2 IC50values range from 47 to 73 nM.

    Bioactivity: Tubulysin A(TubA) is a myxobacterial product that can function as anantiangiogenic agent in many in vitro assays; anti-microtubule,anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, andantiproliferative.

    Taltobulin hydrochloride(HTI-286 hydrochloride; SPA-110 hydrochloride) Cat. No.: HY-15584B

    Taltobulin trifluoroacetate (HTI-286 trifluoroacetate; SPA-110 trifluoroacetate) Cat. No.: HY-15584A

    Triptolide(PG490; PG 490; PG-490) Cat. No.: HY-32735

    Tubulysin A(TubA) Cat. No.: HY-15995

    http://www.medchemexpress.com/Taltobulin-hydrochloride.htmlhttp://www.medchemexpress.com/Taltobulin-trifluoroacetate.htmlhttp://www.medchemexpress.com/Triptolide.htmlhttp://www.medchemexpress.com/Tubulysin-A.html

  • ADC Linker 

    Antibody-drug conjugates (ADCs) are a new class of highly potentbiopharmaceutical drugs designed as a targeted therapy for thetreatment of people with cancer. ADCs are complex moleculescomposed of an antibody, a linker and a biological active cytotoxic.ADCs linkers are based on chemical motifs including disulfides,hydrazones or peptides (cleavable), or thioethers (noncleavable) andcontrol the distribution and delivery of the cytotoxic agent to thetarget cell. Cleavable and noncleavable types of linkers have beenproven to be safe in preclinical and clinical trials. A stable linkbetween the antibody and cytotoxic (anti-cancer) agent is a crucialaspect of an ADC.

    8 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

    http://www.medchemexpress.com/Targets/ADC Linker.html

  • www.MedChemExpress.com 9

    Purity: 98.72%Clinical Data:Size: 10mM x 1mL in DMSO,

    100 mg, 500 mg, 1 g

    Purity: 98.55%Clinical Data:Size: 10mM x 1mL in DMSO,

    10 mg, 50 mg, 100 mg, 200 mg

    Purity: 95.07%Clinical Data:Size: 10mM x 1mL in DMSO,

    50 mg, 100 mg

    Purity: 98.53%Clinical Data:Size: 10mM x 1mL in DMSO,

    5 mg, 10 mg, 50 mg, 100 mg

    Purity: 96.52%Clinical Data:Size: 10mM x 1mL in DMSO,

    1 g

    Purity: 98.05%Clinical Data:Size: 10mM x 1mL in DMSO,

    10 mg, 50 mg, 100 mg

    Purity: >98%Clinical Data:Size: 5 mg, 10 mg, 50 mg, 100 mg

    ADC Linker Inhibitors & Modulators

    Bioactivity: (Ac)Phe-Lys(Alloc)-PABC-PNP is a useful chemical linker in antibodydrug conjugates.

    Bioactivity: 6-Maleimidohexanoic acid N-hydroxysuccinimide ester(ECMS) is auseful protective group in antibody drug conjugates.

    Bioactivity: 6-Quinoxalinecarboxylic acid, 2,3-bis(bromomethyl)- is an usefullinker for antibody-drug-conjugations (ADCs), extracted from [BioorgChem. 2012 Apr-Jun;41-42:1-5.] compound 1i.

    Bioactivity: Fmoc-Val-Cit-PAB is a linker for antibody-drug-conjugation (ADC).

    Bioactivity: Fmoc-Val-Cit-PAB-PNP is a peptide prodrug linker, is a linker forantibody-drug-conjugation (ADC).

    Bioactivity: Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC peptide linker.FDA approved drug, brentuximab vedotin, adopts this linker.

    Bioactivity: Val-cit-PAB-OH is a peptide prodrug linker.

    (Ac)Phe-Lys(Alloc)-PABC-PNPCat. No.: HY-20560

    6-Maleimidohexanoic acid N-hydroxysuccinimide ester(EMCS) Cat. No.: HY-78961

    6-Quinoxalinecarboxylic acid, 2,3-bis(bromomethyl)-Cat. No.: HY-21210

    Fmoc-Val-Cit-PABCat. No.: HY-19318

    Fmoc-Val-Cit-PAB-PNPCat. No.: HY-41189

    Mc-Val-Cit-PABC-PNP (Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate) Cat. No.: HY-20336

    Val-cit-PAB-OHCat. No.: HY-12362

    http://www.medchemexpress.com/Targets/ADC Linker.htmlhttp://www.medchemexpress.com/_ac_phe-lys_alloc_-pabc-pnp.htmlhttp://www.medchemexpress.com/6-maleimidohexanoic-acid-n-hydroxysuccinimide-ester.htmlhttp://www.medchemexpress.com/6-Quinoxalinecarboxylic-acid,-2,3-bis_bromomethyl_-.htmlhttp://www.medchemexpress.com/Fmoc-Val-Cit-PAB.htmlhttp://www.medchemexpress.com/Fmoc-Val-Cit-PAB-PNP.htmlhttp://www.medchemexpress.com/Mc-Val-Cit-PABC-PNP.htmlhttp://www.medchemexpress.com/Val-cit-PAB-OH.html

  • Drug-Linker Conjugates for ADC 

    10 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

    http://www.medchemexpress.com/Targets/Drug-Linker Conjugates for ADC.html

  • www.MedChemExpress.com 11

    Purity: >98%Clinical Data:Size: 10mM x 1mL in DMSO,

    1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

    Purity: 95.23%Clinical Data:Size: 10mM x 1mL in DMSO,

    2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

    Purity: >98%Clinical Data:Size: 1 mg, 5 mg, 10 mg

    Purity: 99.47%Clinical Data:Size: 10mM x 1mL in DMSO,

    1 mg, 5 mg, 10 mg

    Purity: 97.23%Clinical Data:Size: 10mM x 1mL in DMSO,

    1 mg, 5 mg, 10 mg

    Purity: 96.95%Clinical Data:Size: 10mM x 1mL in DMSO,

    1 mg, 5 mg, 10 mg

    Purity: 99.57%Clinical Data:Size: 10mM x 1mL in DMSO,

    1 mg, 5 mg, 10 mg

    Purity: 98.89%Clinical Data:Size: 10mM x 1mL in DMSO,

    1 mg, 5 mg, 10 mg

    Purity: >98%Clinical Data:Size: 1 mg

    Purity: 96.5%Clinical Data:Size: 10mM x 1mL in DMSO,

    1 mg, 5 mg, 10 mg

    Drug-Linker Conjugates for ADC Inhibitors & Modulators

    Bioactivity: Acetylene-linker-Val-Cit-PABC-MMAE consists the ADCs linker(Acetylene-linker-Val-Cit-PABC) and potent tubulin inhibitor (MMAE),Acetylene-linker-Val-Cit-PABC-MMAE is an antibody drug conjugate.

    Bioactivity: Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, is atoxin payload in antibody drug conjugate.

    Bioactivity: Fmoc-Val-Cit-PAB-MMAE consists the ADCs linker(Fmoc-Val-Cit-PAB) and potent tubulin inhibitor (MMAE),Fmoc-Val-Cit-PAB-MMAE is an antibody drug conjugate.

    Bioactivity: MAL-di-EG-Val-Cit-PAB-MMAE consists the ADCs linker(MAL-di-EG-Val-Cit-PAB) and potent inhibitor (MMAE),tubulinMAL-di-EG-Val-Cit-PAB-MMAE is an antibody drug conjugate.

    Bioactivity: Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, is atoxin payload in antibody drug conjugate; Mc-MMAD is a protectivegroup (maleimidocaproyl) -conjugated MMAD.

    Bioactivity: Mc-MMAE is a protective group (maleimidocaproyl)-conjugatedmonomethyl auristatin E (MMAE), which is a potent inhibitor,tubulinis a toxin payload in antibody drug conjugate ( ).ADC

    Bioactivity: Mc-MMAF is a protective group-conjugated MMAF. MMAF is a morepotent drug than Monomethyl auristatin E (MMAE), but is chargedand relatively membrane-impermeable, is a potent tubulin inhibitor,is a toxin payload in antibody drug conjugate.

    Bioactivity: mDPR-Val-Cit-PAB-MMAE consists the ADCs linker(mDPR-Val-Cit-PAB) and potent tubulin inhibitor (MMAE),mDPR-Val-Cit-PAB-MMAE is an antibody drug conjugate.

    Bioactivity: Mertansine is a tubulin inhibitorinhibits the assemblyof microtubulesby binding to tubulin, with a linker structure can create anantibody-drug conjugate (ADC).

    Bioactivity: SMCC-DM1 is DM1 with a reactive linker SMCC to make antibodydrug conjugate. DM1 (mertansine), a thiol-containing maytansinoid,is a potent microtubule-disrupting agent.

    Acetylene-linker-Val-Cit-PABC-MMAE(LCB14-0602) Cat. No.: HY-19812

    Cys-mcMMADCat. No.: HY-15750

    Fmoc-Val-Cit-PAB-MMAECat. No.: HY-19811

    MAL-di-EG-Val-Cit-PAB-MMAECat. No.: HY-100567

    Mc-MMAD(Mc MMAD; McMMAD) Cat. No.: HY-15740

    Mc-MMAE (Maleimidocaproyl-monomethylauristatin E; Mc MMAE; McMMAE) Cat. No.: HY-15741

    McMMAF(mc-MMAF; Maleimidocaproyl monomethylauristatin F) Cat. No.: HY-15578

    mDPR-Val-Cit-PAB-MMAECat. No.: HY-19813

    Mertansine (DM1; Maytansinoid DM1; DM-1; Maytansinoid DM-1; DM 1;Maytansinoid DM 1) Cat. No.: HY-19792

    SMCC-DM1(DM1-SMCC) Cat. No.: HY-101070

    http://www.medchemexpress.com/Targets/Drug-Linker Conjugates for ADC.htmlhttp://www.medchemexpress.com/Acetylene-linker-Val-Cit-PABC-MMAE.htmlhttp://www.medchemexpress.com/cys-mcmmad.htmlhttp://www.medchemexpress.com/Fmoc-Val-Cit-PAB-MMAE.htmlhttp://www.medchemexpress.com/MAL-di-EG-Val-Cit-PAB-MMAE.htmlhttp://www.medchemexpress.com/Mc-MMAD.htmlhttp://www.medchemexpress.com/Mc-MMAE.htmlhttp://www.medchemexpress.com/McMMAF.htmlhttp://www.medchemexpress.com/mDPR-Val-Cit-PAB-MMAE.htmlhttp://www.medchemexpress.com/Mertansine.htmlhttp://www.medchemexpress.com/SMCC-DM1.html

  • Purity: 99.66%Clinical Data:Size: 10mM x 1mL in DMSO,

    1 mg, 5 mg, 10 mg, 50 mg

    Purity: 98.51%Clinical Data:Size: 10mM x 1mL in DMSO,

    1 mg, 5 mg, 10 mg

    Purity: 99.76%Clinical Data:Size: 10mM x 1mL in DMSO,

    1 mg, 5 mg, 10 mg

    Purity: 94.27%Clinical Data:Size: 10mM x 1mL in DMSO,

    1 mg, 5 mg, 10 mg

     

    Bioactivity: SuO-Val-Cit-PAB-MMAE is a bydrug-linker conjugate for ADCusing the anti-mitotic agent, monomethyl auristatin E (MMAE), linkedvia the peptide SuO-Val-Cit-PAB.

    Bioactivity: Val-Cit-PAB-MMAE is a by using thedrug-linker conjugate for ADCanti-mitotic agent, monomethyl auristatin E (MMAE), linked via thepeptide Val-Cit-PAB.

    Bioactivity: Vc-MMAD consists the ADCs linker(Val-Cit) and potent tubulininhibitor (MMAD), Vc-MMAD is an antibody drug conjugate

    Bioactivity: VcMMAE is a with potent antitumordrug-linker conjugate for ADCactivity by using the anti-mitotic agent, monomethyl auristatin E(MMAE), linked via the lysosomally cleavable dipeptide,valine-citrulline (vc).

    12 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

    SuO-Val-Cit-PAB-MMAECat. No.: HY-100566

    Val-Cit-PAB-MMAECat. No.: HY-100374

    Vc-MMAD(Vc MMAD; VcMMAD) Cat. No.: HY-15742

    VcMMAECat. No.: HY-15575

    http://www.medchemexpress.com/SuO-Val-Cit-PAB-MMAE.htmlhttp://www.medchemexpress.com/Val-Cit-PAB-MMAE.htmlhttp://www.medchemexpress.com/Vc-MMAD.htmlhttp://www.medchemexpress.com/VcMMAE.html