antibiotics and antiparasiticals. flexible solutions for...

Antibiotics and Antiparasiticals.Flexible solutions for germs controlin poultry and livestock industry !

www.delosmedica.com

ABOUT US

Well known on the Romanian market DELOS Medica has consolidated its position during these years on the Romanian market for veterinary drugs. Our activity con-sists in manufacturing veterinary drugs and their direct distribution throughout the territory of Romania and other exporting countries.

The main arguments in our favour, are:• 20 years experience gathered in relentless work in the field.• Our staff ’s professionalism and the quality of our products and services.• Reliability, given by an excellent business relationship with our partners and

clients.

THE FACTORY

The factory, built by us in 2008, is GMP certified and respecting the quality stan-dards imposed by European Pharmaceutical regulations. The factory has 3 produc-tion lines: WS Powders and Premixes, oral solutions, and it is planned to launch a tablets and an injectable line.

We have as target species livestock such as poultry, pigs, cattle, and sheep.The modern storage spaces and transportation vehicles, ensure conformity with the products quality standards until they reach our clients.

OUR TEAM

One of the most important resources of the company is represented by its staff. From the total of our staff (containing 30 people), there are 5 highly experienced veterinar-ians with a rich experience in the distribution field that work with us, and 2 more experienced veterinarians as external collaborators. Plus another 4 employees with high academic and economical training. Delos Medica‘s distribution benefits by a high expertise ensured by the veterinary experts of the company.

www.delosmedica.com www.delosmedica.com

Oral solutionsBromex ............................................................ 04 - 05Colidem ............................................................ 06 - 07Enrodem 10% ............................................................ 08 - 09Florfenidem 10% ........................................................ 10 - 11Tilmicodem 25 ............................................................ 12 - 13Tilodem ............................................................ 14 - 15Vermicid 10 ............................................................ 16 - 17Vermicid 2,5 ............................................................ 18 - 19

Water Soluble PowdersAmoxidem 50% .......................................................... 20 - 21Clortetradem 50 .......................................................... 22 - 23Colidem 50 ............................................................ 24 - 25Doxidem 50 ............................................................ 26 - 27Lincodem 50 ............................................................ 28 - 29Oxidem 50 ............................................................ 30 - 31Tiadem 80 ............................................................ 32 - 33Tilodem 50 ............................................................ 34 - 35

Premixes Amoxidem 10% .......................................................... 36 - 37Clortetradem 10% ...................................................... 38 - 39Colidem 10% ............................................................ 40 - 41Enrodem 50 ............................................................ 42 - 43Fenbadem 10% ............................................................ 44 - 45Florfenidem 50 ............................................................ 46 - 47Lincodem 10% ............................................................ 48 - 49Tiadem 10% ............................................................ 50 - 51Tilodem 10% ............................................................ 52 - 53

TABLE OF CONTENTS

03

Oral solutions range

BROMEXOral solution for poultry

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• Unique formulation • Allows a high concentra-

tion of the enrofloxacine in the respiratory mucus

• Excellent efficiency rate

NAME OF THE VETERINARY MEDICINAL PRODUCTBROMEX, 200 mg enrofloxacin /ml, 15 mg bromhexine HCl/ml, oral solution for poultry (chicken broilers, breeders, replace-ment chickens).

STATEMENT OF THE ACTIVE SUBSTANCE AND OTHER INGREDIENTS1 ml solution contains: Enrofloxacin 200 mg, Bromhexine HCl 15 mg, Excipients qs ad. 1 ml.

INDICATIONS: In poultry for treatment of bacterial infection caused by: Mycoplas-ma gallisepticum, Mycoplasma synoviae, Avibacterium paragallinarum, Pasteurella multocida, Escherichia coli.

CONTRAINDICATIONS: Do not use in animals with known hyper-sensitivity to fluoroquinolones.

TARGET SPECIES: Poultry.

DOSAGE FOR EACH SPECIES, ROUTE(S) AND METHOD OF ADMINISTRATIONPoultry (chicken broilers, breeders, replace-ment chickens).The product is administered via drink-ing water in dose of 0.05 ml Bromex/kg bw, continuously for 5 days. From clinical studies these dose may be achieved by the inclusion of 0.3 ml Bromex/litre of drink-ing water, administered continuously for 5 days. Based on the recommended doses

and the number and weight of the animals to be treated, the exact daily amount of Bromex should be calculated according to the following formula:

The uptake of medicated water is depen-dant on the clinical condition of animals. In order to obtain the correct dosage, the concentration in drinking water may have to be adjusted.

ADVICE ON CORRECT ADMINISTRATIONDuring treatment, the animals should drink only medicated water. Fresh medi-cated water should be prepared every 24 hours.

WITHDRAWAL PERIODEdible tissues of poultry: 7 days after cessation of oral medication. Not permitted for use in laying bird producing eggs for human consumption.

SPECIAL PRECAUTIONS FOR STORAGEKeep away from reach and sight of chil-dren! The product should be stored in original packaging at temperatures bellow 25oC, protected from direct sunlight and freeze. Shelf life of the veterinary medicinal product as packaged for sale: 2 years. Shelf life after dilution in drinking water, accor-ding to directions: 24 hours.

05

ml Bromex / kg body weight/day x mean body weight of animals to be treated (kg)

ml Bromex / liter of

drinking waterMean daily water consumption (liters) / animal=


COLIDEMOral solution for pigs and poultry

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• Oral solution - excellent solubility

• Proper concentration of the active ingredient

• Long lasting stability

NAME OF THE VETERINARY MEDICINAL PRODUCTCOLIDEM, as colistin sulphate 200 mg /ml, oral solution for pigs and poultry.

STATEMENT OF THE ACTIVE SUBSTANCE AND OTHER INGREDIENTS1 ml of Colidem contains: Colistin sul-phate 200 mg (minimum 19500 IU/mg), Excipients ad. 1 ml

INDICATIONSIn pigs and chickens: for treatment and metaphylaxis of enteric infections caused by non-invasive E. coli susceptible to colis-tin. The presence of the disease in the herd should be established before metaphylac-tic treatment.

CONTRAINDICATIONSDo not give to animals with known hyper-sensitivity to polymixines.

TARGET SPECIESPigs and poultry.

DOSAGE FOR EACH SPECIES, ROUTE(S) AND METHOD OF ADMINISTRATIONIn pigs: the product is administered in drinking water at the therapeutically dos-age of 2-5 mg colistin sulphate /kg bw/day, equivalent to 0,01 – 0,025 ml Colidem /kg bw/day, for 3-5 consecutive days.In poultry: the product is administered in drinking water at the therapeutically dosage of 2-5 mg colistin sulphate /kg bw/day, equivalent to 0,01 – 0,025 ml

Colidem /kg bw/day, for 3-5 consecutive days. Based on the recommended doses and the number and weight of the animals to be treated, the exact daily amount of COLIDEM should be calculated accord-ing to the following formula:

The uptake of medicated water is depen-dant on the clinical condition of animals. In order to obtain the correct dosage, the concentration in drinking water may have to be adjusted.


WITHDRAWAL PERIODFor pig and poultry meat and organs: 2 day from cessation of treatment. For eggs: zero days from the cessation of treatment.

SPECIAL PRECAUTIONS FOR STORAGEKeep away from reach and sight of chil-dren! The product should be stored in original packaging at temperature bellow 25oC, protected from direct sunlight and moisture. Protect from freezing. Shelf life of the veterinary medicinal product as packaged for sale: 2 years. Shelf life after dilution in drinking water, according to directions: 24 hours.

07

ml Colidem / kg body weight/day x mean body weight of animals to be treated (kg) ml Colidem /

liter of waterMean daily water consumption (liter) / animal=


ENRODEM 10%Oral solution for pigs and poultry

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• Innovative formulation• Proven homogeneity

in the working solution• Proven high

bioavailability

NAME OF THE VETERINARY MEDICINAL PRODUCTENRODEM 10%, as enrofloxacin 100 mg/ml, oral solution for pigs and poultry.

STATEMENT OF THE ACTIVE SUBSTANCE AND OTHER INGREDIENTS1 ml solution contains: Enrofloxacin 100 mg., Excipients (potassium hydroxide, hypromellose, benzyl alcohol, purifiedwater) ad...1 ml

INDICATIONSIn pigs: for the treatment of gastrointesti-nal, respiratory and urogenitaly infections produced by microorganisms susceptible to enrofloxacin: Gram Negative bacteria (Pseudomonas aeruginosa, Pasteurella spp, Salmonella spp, E.coli, Actinobacillus spp, Shigella, Klebsiella, Brachispira, Cam-pylobacter etc) Gram positive bacteria (Erysipelothrix rhusiopatiae, some strains of Streptococcus and Staphylococcus spp. etc), Mycoplasma, Brucella, Chlamydia.In poultry for treatment of bacterial infection caused by: Mycoplasma gallisep-ticum, Mycoplasma synoviae, Avibacterium paragallinarum, Pasteurella multocida, Escherichia coli.

CONTRAINDICATIONSDo not use in animals with known hyper-sensitivity to fluoroquinolones.Do no use in pregnant females. The prod-uct should not be used as preventivetreatment.


DOSAGE FOR EACH SPECIES,ROUTE(S) AND METHOD OF ADMINISTRATIONIn pigs: the product is administered via drinking water in dosage of 5 mg enro-

floxacin/kg body weight/day, correspond-ing to 0.05 ml Enrodem 10% / kg body weight/day, for 5 consecutive days.In poultry: the product is administered via drinking water in dosage of 10 mg enrofloxacin/kg b.w. corresponding to 0.1 ml Enrodem 10%/day for 5 consecutive days. Based on the recommended doses and the number and weight of the animals to be treated, the exact daily amount of Enrodem 10% should be calculated ac-cording to the following formula:


WITHDRAWAL PERIODEdible tissues of poultry and pigs: 7 days after cessation of oral medication.Not permitted for use in laying bird pro-ducing eggs for human consumption.

SPECIAL PRECAUTIONS FOR STORAGEKeep away from reach and sight of chil-dren! The product should be stored in original packaging at temperatures bellow 250C, protected from direct sunlight and freeze. Shelf life of the veterinary medici-nal product as packaged for sale: 2 years.Shelf life after dilution in drinking water, according to directions: 24 hours.

09

ml Enrodem10% / kg body weight/day x mean body weight of animals to be treated (kg)

ml Enrodem 10% / liter drinking

waterMean daily water consumption (liters) / animal=


FLORFENIDEM 10%100 mg florfenicol /ml oral solution for pigs and poultry

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• Better solubility than other florfenicol oral formulation

• 100% veterinary antibiotic• Proven efficacy in most

of the respiratory syndromes

NAME OF THE VETERINARY MEDICINAL PRODUCT: Florfenidem 10%, as florfenicol 100 mg/ml, oral solution for pigs and poultry.

STATEMENT OF THE ACTIVE SUBSTANCE AND OTHER INGREDIENTSFlorfenidem 10% is a viscous, yellowish solu-tion. Each ml of Florfenidem 10% contains: Flor-fenicol (active substance) 100 mg, Excipients ad.1 ml.

INDICATIONSIn pigs: for treatment of respiratory and digestive infections produced by susceptible bacteria: Pasteurella multocida, Pasteurella haemolitica, Actinobacillus pleuropneumoni-ae, Bordetella bronchiseptica, Salmonella spp., Escherichia coli, Haemophilus parasuis, Staphylococus spp., Streptococus suis, Cory-nebacterium pyogenes, Shigella spp., Klebsiella pneumoniae, Micoplasma spp.In poultry: for treatment of respiratory and digestive bacterial infections produced by susceptible bacteria: Pasteurella multocida, Bordetella bronchiseptica, Salmonella spp., Escherichia coli, Haemophilus paragalinarum, Staphylococus spp., Streptococus spp., Ornitho-bacterium rhinotracheale and Corynebacte-rium pyogenes.

CONTRAINDICATIONS:Do not administer in animals with known hypersensitivity at amphenicols. Do not administer to pregnant sows or in lactation period and breeding boars.


DOSAGE FOR EACH SPECIES, ROUTE(S) AND METHOD OF ADMINISTRATION The product is administered via drinking water in pigs and poultry as following:In pigs: the product is administered via drinking water in dosage of 1,5 – 2 mg

florfenicol/kg body weight/day (b.w.) for 5-7 days: - in youngster pigs 1,5 ml product/ 100 kg b.w./day and - in adult pigs 2 ml/100kg b.w./day.In poultry: the product is administered via drinking water in dosage of 20 mg/kg b.w.:0.2 ml of product/kg b.w./day in birds under 4 weeks of age, and 0.4 ml of product/kg b.w./day in birds over 4 weeks of age, for 3 -5 days. Based on the recommended doses and the number and weight of the animals to be treated, the exact daily amount of Florfeni-dem 10% should be calculated according to the following formula:

ADVICE ON CORRECT ADMINISTRATION During treatment, the animals should drink only medicated water. If this is not possible the daily dosage must be divided in two and administered once in 12 hours.

WITHDRAWAL PERIODFor pig meat: 1 day from the last administra-tion. For poultry meat: 2 days from the last administration. Not permitted for use in laying bird produc-ing eggs for human consumption.

SPECIAL PRECAUTIONS FOR STORAGEKeep away from reach and sight of children! Store in original packaging, at temperature bellow (15 - 250C), protected from direct sunlight and frost.Shelf life of the veterinary medicinal product as packaged for sale: 2 years. Shelf life after dilution in drinking water, according to direc-tions: 24 hours.

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ml Florfenidem 10% / kg body weight/day x mean body weight of animals to be treated (kg)

ml Florfenidem 10% / liter



TILMICODEM 25Oral solution for pigs and poultry

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• Excellent solubility• Long lasting stability• Proven efficacy in tylosin

resistant pathogens

NAME OF THE VETERINARY MEDICINAL PRODUCT: TILMICODEM 25, as tilmicosin phosphate 250 mg/ml, oral solution for pigs and poultry.

STATEMENT OF THE ACTIVE SUBSTANCE AND OTHER INGREDIENTS: 1 ml solution contains: Tilmicosin phosphate: 250 mg (equivalent to 225 mg tilmicosin base), Excipients (pro-pyl gallate, disodium edetate, orthophos-phoric acid, puriffied water) ad. 1 ml.

INDICATIONSIn pigs: for treatment and control of respira-tory infections associated with Mycoplasma hyopneumoniae, Actinobacillus pleuropneu-moniae, Pasteurella multocida, Haemophilus parasuis, Bordetella bronchiseptica and also for other infections produced by tilmicosin susceptible bacteria such as: Fusobacterium spp., Erysipelothrix rhusiopatiae, Listeria, Clostridium spp. etc.In poultry: for treatment of infections produced by susceptible bacteria such as: Mycoplasma spp, Pasteurella multocida, Haemophillus paragalinarum, Streptococcus spp., anaerobs (Clostridium spp.) etc.

CONTRAINDICATIONS: Do not allow horses and other equines ac-cess to drinking water containing Tilmico-dem 25.

TARGET SPECIES: Pigs and poultry.

DOSAGE FOR EACH SPECIES, ROUTE(S) AND METHOD OF ADMINISTRATIONn pigs: the product is administered via drinking water in dosage of 15 - 20 mg tilmicosin phosphate/kg b.w. corresponding to 0.09 ml Tilmicodem 25/kg b.w./day for 3 – 5 consecutive days

In poultry (broilers, breeder hens, replace-ment youth): the product is administered via drinking water in dosage of 15 - 20 mg tilmicosin phosphate/kg b.w. corresponding to 0.08 ml Tilmicodem 25/kg b.w./day for 3 – 5 consecutive days. Based on the recommended doses and the number and weight of the animals to be treated, the exact daily amount of Tilmico-dem 25 should be calculated according to the following formula:

ADVICE ON CORRECT ADMINISTRATION: The product must be diluted before admin-istration to the animals. During treatment, the animals should drink only medicated water. Medicated drinking water should be prepared fresh every 24 hours.

WITHDRAWAL PERIOD: Edible tissues of pig: 7days from cessation of oral medication. Edible tissues of poultry: 13 days from cessation of oral medication. Not permitted for use in laying bird producing eggs for human consumption.

SPECIAL PRECAUTIONS FOR STOR AGE:Keep away from reach and sight of children!Store in original packaging, at room temperature (bellow 250C), protected from moisture and direct sunlight. Shelf life of the veterinary medicinal product as packaged for sale: 2 years. Shelf life after dilution in drinking water, according to directions: 24 hours. Shelf-life after first opening of pack-age: 28 days. Close tight the recipient after use. Do not use after expiry date which is stated on the label.

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ml Tilmicodem 25 / kg body weight/day x mean body weight of animals to be treated (kg)

ml Tilmicodem 25 / liter of



TILODEMOral solution for pigs and poultry

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• Specific cellular mechanism of action

• High quality ingredients• The first tylosin based

medicinal drug formulated as oral solution

NAME OF THE VETERINARY MEDICINAL PRODUCTTILODEM, tylosin tartrate, 200 mg / ml, oral solution for swine and poultry (chickens, turkeys)

STATEMENT OF THE ACTIVE SUBSTANCE AND OTHER INGREDIENTSEach ml Tilodem contains:Active ingredientTylosin tartrate .……….…..…....… 200 mg ExcipientsBenzilic alcohol ………..……….…..0,04ml

INDICATIONSIn pigs: for treatment and control of respira-tory infections associated with Mycoplasma hyopneumoniae, Actinobacillus pleuropneu-moniae, Pasteurella multocida, Haemophilus parasuis, Bordetella bronchiseptica and also for other infections produced by tylosin sus-ceptible bacteria such as: Staphylococcus spp., Fusobacterium spp., Erysipelothrix rhusiopa-tiae, Clostridium spp. etc.In poultry: for treatment and control of avian mycoplasmosis (Mycoplasma gallisepticum, Mycoplasma synoviae), Chronic Respiratory Disease, infections caused by Pasteurella mul-tocida, Staphylococcus spp., Clostridium spp (Necrotic enteritis) also for other infections produced by tylosin susceptible bacteria.

CONTRAINDICATIONS Do not give to animals with known hypersen-sitivity to tylosin or other macrolides.

ADVERSE REACTIONSNone known

TARGET SPECIESPigs and poultry (chickens, turkeys).

DOSAGE FOR EACH SPECIES, ROUTE(S) AND METHOD OF ADMINISTRATIONIn pigs the product is administered via liquid feed or drinking water, in dose of 0.20 ml/kg bw (equivalent with 40 mg tylosin tartrate/kg bw)/day for 5 consecutive days.

In poultry (chickens, turkeys), the product is administered via drinking water, in dose of 0.35 ml/kg bw (equivalent with 70 mg tylosin tartrate/kg bw)/day for 5 consecutive days. Based on the recommended doses and the number and weight of the animals to be treated, the exact daily amount of TILODEM should be calculated according to the follo-wing formula:

The uptake of medicated water or liquid feed is dependant on the clinical condition of ani-mals. In order to obtain the correct dosage, the concentration in drinking water/liquid feed may have to be adjusted.

ADVICE ON CORRECT ADMINISTRATIONThe product must be diluted before adminis-tration to the animals.During treatment, the animals should drink only medicated water. Medicated drinking water should be prepared fresh every 24 hours.

WITHDRAWAL PERIODPigs (meat and offal): 7 days from cessation of oral administration.Chickens, turkeys (meat and offal): 5 days from cessation of oral administration.Eggs: 4 days from cessation of oral adminis-tration.

SPECIAL PRECAUTIONS FOR STORAGEThe product should be stored in original packaging at temperature below 250C, pro-tected from direct sunlight and freeze.Keep away from reach and sight of children!Shelf life of the veterinary medicinal product as packaged for sale: 2 years. Shelf life after dilution in drinking water, according to directions: 24 hours.

15

(ml Tilodem / kg body weight/day) x (mean body weight of animals to be treated (kg)

ml Tilodem / kg

of liquid feedMean daily liquid feed consumption (kg) / animal=

(ml Tilodem / kg body weight/day) x (mean body weight of animals to be treated (kg)

ml Tilodem / liter

of waterMean daily water consumption (liter) / animal=


VERMICID 10Oral suspension for cattle and sheep

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• Proper concentration• Proven efficacy• 100% compliance

with E .Ph.

NAME OF THE VETERINARY MEDICINAL PRODUCTVERMICID 10, 100 mg/g, oral suspension for cattle and sheep. Albendazole.

STATEMENT OF THE ACTIVE SUBSTANCE(S) AND OTHER INGREDIENTS:Albendazole 100 mg, Excipients: Benzoic acid 8 mg

INDICATIONS: The product Vermicid 10 is indicated for the control of albendazole susceptible mature and developing immature forms of the following internal parasites of cattle and sheep:

The product has also ovicidal activity. As pro-phylactic purposes, the deworming program should consist in 3-4 administrations: before entering to pasture, in July and September and after housing the animals.

CONTRAINDICATIONS: Do not administer to animals with known hypersensitivity to benzimidazoles or the excipients.

TARGET SPECIES: Cattle and sheep.

DOSAGE FOR EACH SPECIES, ROUTE(S) AND METHOD OF ADMINISTRATION:To ensure administration of a correct dose, body weight should be determined as ac-curately as possible; accuracy of the dosing device should be checked. The therapeutically dosage is approximately 10 – 12.5 mg alben-dazole per kg bodyweight.Cattle: 5 ml / 40 kg b.w. (12.5 mg albendazole/kg bw); Sheep: 4 ml/40 kg b.w. (10 mg alben-dazole/kg bw).

WITHDRAWAL PERIOD: Cattle: 28 days for meat; Sheep: 4 days for meat; Milk: 3 days.

Animals must not be slaughtered for human consumption during treatment. Milk for hu-man consumption must not be taken during treatment.

SPECIAL PRECAUTIONS FOR STORAGE: Store in original packaging, at temperature between 15- 250C, protected from direct sun-light and freeze. Keep away from reach and sight of children! Shelf life of the veterinary medicinal product as packaged for sale: 2 years.

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Parasitosis Cattle Sheep

Control of adult liver flukes Fasciola hepatica, Dicrocelium lanceolatum Fasciola hepatica, Dicrocelium lanceolatum

Control of tapeworms Moniezia benedeni, M. expansa Moniezia expansa

Gastro-intestinal roundworms (L4 larvae and adults)

Ostertagia ostertagi (including inhibited larvae L4), Haemonchus contortus,Trichostrongylus axei

Ostertagia circumcincta (including inhibi ted larvae L4), Coopperia oncophora, Haemonchus

contortus,Trichostrongylus axei


Nematodirus spathiger,Cooperia oncophora (including inhibited larvae L4)

Nematodirus spathiger, N. filicolis, Cooperia oncophora, Trichostrongylus colubriformis, Oesophagostomum

columbianum, Chabertia ovina

Gastro-intestinal adult roundworms Bunostomum phlebotomum, Trichostrongylus colubriformis,Oesophagostomum radiatum

Lungworms (larva and adults) Dictiocaulus viviparus Dictiocaulus filaria


VERMICID 2,5Oral suspension for cattle and sheep

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18

• Proven efficacy• Long lasting stability• 100% compliance

with E .Ph. 6

NAME OF THE VETERINARY MEDICINAL PRODUCT: VERMICID 2,5, 25 mg/g albendazole, oral suspension for cattle and sheep.

STATEMENT OF THE ACTIVE SUBSTANCE(S) AND OTHER INGREDIENTS: Albendazole 25 mg, Excipients: Benzoic acid 5 mg

INDICATIONSThe product VERMICID 2,5 is indicated for the control of albendazole susceptible mature and developing immature forms of the fol-lowing internal parasites of cattle and sheep:

The product has also ovicidal activity. As pro-phylactic purposes, the deworming program should consist in 3-4 administrations: before entering to pasture, in July and September and after housing the animals.

CONTRAINDICATIONS: Do not administer to animals with known hypersensitivity to benzimidazoles or the excipients.

TARGET SPECIES: Cattle and sheep.

DOSAGE FOR EACH SPECIES, ROUTE(S) AND METHOD OF ADMINISTRATIONTo ensure administration of a correct dose, body weight should be determined as ac-curately as possible; accuracy of the dosing device should be checked. The therapeutically dosage is approximately 10 – 12.5 mg alben-dazole per kg bodyweight. Cattle: 20 ml / 40 kg b.w. (12.5 mg albenda-zole/kg bw); Sheep: 16 ml/ 40kg b.w. (10 mg albendazole/kg bw).

WITHDRAWAL PERIOD: Cattle: 28 days for meat; Sheep: 4 days for meat.; Milk: 3 days. Animals must not be slaughtered for human consumption during

treatment. Milk for human consumption must not be taken during treatment.

SPECIAL PRECAUTIONS FOR STORAGEStore in original packaging, at temperature between 15-250C, protected from direct sun-light and freeze. Keep away from reach and sight of children! Shelf life of the veterinary medicinal product as packaged for sale: 2 years.

19

Parasitosis Cattle Sheep

Control of adult liver flukes Fasciola hepatica, Dicrocelium lanceolatum Fasciola hepatica, Dicrocelium lanceolatum

Control of tapeworms Moniezia benedeni, M. expansa Moniezia expansa


Ostertagia ostertagi (including inhibited larvae L4), Haemonchus contortus,Trichostrongylus axei

Ostertagia circumcincta (including inhibited larvae L4), Coopperia oncophora, Haemonchus

contortus,Trichostrongylus axei


Nematodirus spathiger,Cooperia oncophora (including inhibited larvae L4)

Nematodirus spathiger, N. filicolis, Cooperia oncophora, Trichostrongylus colubriformis, Oesophagostomum

columbianum, Chabertia ovina

Gastro-intestinal adult roundworms Bunostomum phlebotomum, Trichostrongylus colubriformis,Oesophagostomum radiatum

Lungworms (larva and adults) Dictiocaulus viviparus Dictiocaulus filaria

AMOXIDEM 50%Water-soluble powder for pigs and poultry

20

Water soluble powders rangewww.delosmedica.com

mg Amoxidem 50% / kg body weight / day x mean body weight of animals to be treated

mg Amoxidem 50 / liter


21

NAME OF THE VETERINARY MEDICINAL PRODUCTAMOXIDEM 50%, 500 mg/g amoxicilina trihidrat, water-soluble powder for pigs and poultry.

STATEMENT OF THE ACTIVE SUBSTANCE(S) AND OTHER INGREDIENTSAMOXIDEM 50% is a white water-soluble powder that contains per 1 gram:Amoxicillin trihydrate .................... 500 mg (equivalent to 434,78 mg amoxicillin as base)Excipient (lactose monohydrate) up to. .......... 1 g

INDICATIONS: In pigs: Amoxidem 50% is used for treatment and control of infections produced by susceptible bacteria from genera: Staphylococcus, Streptococcus, Corynebacterium, Clostridium, Salmonella, Escherichia coli, Klebsiella, Pasteurella, Erysipelothrix rhusiopatiae, Haemophilus, Brucella, Fusobacterium, Bacillus, Serpulina (Brachispira) hyodisenteriae and Leptospira. In poultry: for treatment and control of infections produced by susceptible bacteria from genera: Staphylococcus, Streptococcus, Corynebacterium, Clostridium, Salmonella, Escherichia coli, Klebsiella, Pasteurella, Haemophilus, Erysipelothrix rhusiopatiae, Fusobacterium, Bacillus and Borellia

CONTRAINDICATIONS Do not administer to animals with known hypersensitivity to penicillins, beta-lactams and cephalosporins.The product must not be administered in small rodents such as hamsters, Guinea pigs, rabbits, chinchillas. The amoxicillin is altering the intestinal microflora of these animals leading to lethal enterocolitis.


DOSAGE FOR EACH SPECIES, ROUTE(S) AND METHOD OF ADMINISTRATIONAmoxidem 50% is administered via drinking water in the following dosages: Pigs: 8 - 16 mg Amoxidem 50% /kg b.w./day), for 5 consecutive days.

Poultry: 300 – 400 g Amoxidem 50% per 1000 liters of drinking water, for 5 consecutive days.

Based on the recommended doses and the number and weight of the animals to be treated, the exact daily amount of Amoxidem 50% should be calculated according to the following formula:

In drinking water

The uptake of medicated water is dependant on the clinical condition of animals. In order to obtain the correct dosage, the concentration in drinking water may have to be adjusted. The use of suitable calibrating weighing equipment is recommended if part packs are used.

ADVICE ON CORRECT ADMINISTRATIONDuring treatment, the animals should drink only medicated water. To ensure a correct dosage, body weight should be determined as accurately as possible to avoid underdosing.

WITHDRAWAL PERIODPoultry: edible tissues: 28 days after cessation of oral medication. Pigs: edible tissues: 6 days after cessation of oral medication.Not permitted for use in laying birds producing eggs for human consumption.

SPECIAL PRECAUTIONS FOR STORAGEKeep away from reach and sight of children! The product should be stored in original packaging at temperature bellow 250C, protected from direct sunlight and moisture. Shelf life of the veterinary medicinal product as packaged for sale: 2 years. Shelf life after dilution in drinking water, according to directions: 6 hours.

• Anti-infective for systemic use• Active against a wide range of

G+ & G- microorganisms• High quality active ingredients

CLORTETRADEM 50Water-soluble powder for pigs and poultry

22

Water soluble powders rangewww.delosmedica.com

mg Clortetradem 50 / kg body weight/day x mean body weight of animals to be treated (kg)

mg Clortetradem 50 / liter


23

CLORTETRADEM 50500 mg/g clortetraciclină clorhidrat

Pulbere hidrosolubilă, pentru porcine şi păsări (pui carne, păsări de reproducţie, găini ouă consum, tineret înlocuire)

Clortetraciclină clorhidrat ……..…………………………………....... 500 mg (corespunzător a 463 mg clortetraciclină bază)

Excipient (lactoză monohidrat) qs. ad. …………………………...... 1 g

FORMA FARMACEUTICĂ: Pulbere hidrosolubilă, de culoare galbenă.

MOD ŞI CALE DE ADMINISTRARE: citiţi prospectul înainte de utilizare.

TIMP DE AŞTEPTARE: Pentru carne de porc: 7 zile de la ultima administrare; Pentru carne de pasăre: 3 zile de la ultima adminis-

trare. Pentru ouă: 3 zile de la ultima administrare.ATENŢIONĂRI SPECIALE: citiţi prospectul înainte de utilizare.

CONDIŢII SPECIALE PENTRU DEPOZITARE: A se păstra în ambalajul original, la temperatura camerei (15 - 25°C), ferit de

umiditate şi lumina solară directă. După deschiderea ambalajului, produsul se va utiliza imediat.

PRECAUŢII SPECIALE PENTRU ELIMINAREA PRODUSELOR NEUTILIZATE SAU A DEŞEURILOR: produsul sau deşeurile

rezultate nu se aruncă la resturi menajere sau în ape reziduale, ci în locuri special amenajate. Orice produs farmaceutic veterinar

neutilizat sau deşeu provenit din utilizarea unor astfel de produse trebuie eliminate în conformitate cu cerinţele locale.

Produsul Clortetradem 50 se eliberează numai pe bază de prescripţie medicală.A nu se lăsa la îndemâna copiilor!

Autorizaţie de comercializare nr . 110146 Dimensiunea ambalajului: 1kg Data expirării: 04.2016 Seria: 96

• Excellent concentration in respiratory tissues

• Wide spectrum of G+ and G- bacteria

• An antibiotic that is coming back to foreground

STATEMENT OF THE ACTIVE SUBSTANCE AND OTHER INGREDIENTSCLORTETRADEM 50 is a yellow powder. 1 gram of Clortetradem 50 contains: chlortetracycline hydrochloride 500 mg (equivalent to 463 mg chlortetracycline base), Excipient (lactose monohydrate) qs ad. 1 g

INDICATIONSIn pigs, CLORTETRADEM 50 is indicated for use in treatment of infections caused by certain susceptible species of the genera: Corynebacterium, Erysipelothrix, Listeria, Actinobacillus, Bordetella, Francisella, Haemophilus, Pasteurella, Manhaemia, Campylobacter, Leptospira, Actinomyces, Mycoplasma, Chlamydia, Rickettsia.In poultry (broilers, poultry breeding, youth replacement, laying hens) CLORTETRADEM 50 is indicated for treatment of infections caused by certain susceptible species of the ge-nera: Corynebacterium, Erysipelothrix, Listeria, Streptococcus, Actinobacillus, Bordetella, Fran-cisella, Haemophilus, Pasteurella, Campylo bacter, Borrelia, Leptospira, Actinomyces, Myco plasma, Chlamydia, Rickettsia and Anaplasma spp

CONTRAINDICATIONSDo not give to animals with known hypersensitivity to tetracycline.

ADVERSE REACTIONSSometimes, at animals with severe renal may occur adverse reactions manifested by anorexia, vomiting, abdominal cramps, diarrhea, painful defecation. Possible toxicities due to high concentrations of chlortetracycline in the blood and tissues that occur after the administration of large doses repeated at intervals of less than recommended in the prospectus or in case of severe renal insufficiency. Digestive: anorexia, vomiting, diarrhea, abdominal cramps, pancreatitis; Clortetradem 50 administrated for a long time can cause staphylococcal enteritis or candidiasis (oral, intestinal, lung).Teeth: dental pigmentation, caries, enamel hypoplasia in neonates and infants whose mothers received chlortetracycline during pregnancy or after birth and youth.

TARGET SPECIESPigs and poultry (broilers, poultry breeding, youth replacement, laying hens)

DOSAGE FOR EACH SPECIES, ROUTE(S) AND METHOD OF ADMINISTRATIONIn poultry: the product is administered per

os in dosage of 20-50 mg chlortetracycline base / kg body weight / day (21.60 - 54 mg chlortetracycline hydrochloride / kg body weight / day, approximately 44-108 mg Clortetradem 50 / kg body weight / day) for 3-5 consecutive days.In pigs: the therapeutic dose is 40 mg chlortetracycline base / kg body weight / day (43.2 mg chlortetracycline hydrochloride / kg body weight / day, approximately 87 mg Clortetradem 50 / kg body weight / day) for 3-5 consecutive days. The exact daily amount of CLORTETRADEM 50 should be calculated according to the following formula:

In drinking water:The uptake of medicated water is dependent on the clinical condition of animals. In order to obtain the correct dosage, the concentration in drinking water may have to be adjusted.

ADVICE ON CORRECT ADMINISTRATIONIt is recommended that treatment be initiated after the antibiogram. If this is not possible, treatment should be made based on local epide-miological information (region, farm). Through-out the treatment, animals should drink only medicated water. Every 24 hours is prepared fresh medicated water. In order to ensure the ap-propriate dosage, the body weight of the animals shall be calculated as accurately as possible, in order to avoid under-dosing of the product.

WITHDRAWAL PERIODPig meat: 7 days after the last administration.Poultry meat: 3 days after the last administra-tion. Eggs: 3 days after the last administration.

SPECIAL PRECAUTIONS FOR STORAGEKeep away from reach and sight of children! Store in original packaging, at room temperature (15-250C), protected from moisture and direct sunlight. Shelf life of the veterinary medicinal product as packaged for sale: 2 years. Shelf life after dilution in drinking water, accord-ing to directions: 24 hours. Shelf-life after first opening of package: immediately. Do not use after expiry date which is stated on the label.

Water soluble powders range

COLIDEM 50Water soluble powder for pigs and poultry

www.delosmedica.com

24

NAME OF THE VETERINARY MEDICINAL PRODUCT:COLIDEM 50, water-soluble powder, 500 mg colistin sulphate/gram, for pigs and poultry.

STATEMENT OF THE ACTIVE SUBSTANCE AND OTHER INGREDIENTS:1 gram of Colidem 50 contains: Colistin sulphate 500 mg (minimum 19500 IU/mg), Excipient (lactose monohydrate) qs ad. 1 g INDICATIONS:In pigs and poultry: For treatment and metaphylaxy of intestinal infections caused by non-invasive colistin-suscep-tible strains of E. coli.

CONTRAINDICATIONS:Do not give to animals with known hypersensitivity to polymixines.

TARGET SPECIES:Pigs and poultry.

DOSAGE FOR EACH SPECIES, ROUTE(S) AND METHOD OF ADMINISTRATION:In pigs: the product is administered at the therapeutically dosage of 2-5 mg colistin sulphate /kg bw/day, equivalent with 4 – 10 mg Colidem 50/kg bw/day, for 3-5 consecutive days.In poultry: the product is administered

in drinking water at the therapeutically dosage of 2-5 mg colistin sulphate /kg bw/day, equivalent with 4 – 10 mg Colidem 50/kg bw/day, for 3-5 consecu-tive days. Based on the recommended doses and the number and weight of the animals to be treated, the exact daily amount of COLIDEM 50 should be calculated according to the following formula:

ADVICE ON CORRECT ADMINISTRATION:During treatment, the animals should drink only medicated water.

WITHDRAWAL PERIOD:Meat and offal (pig, poultry): 3 days from cessation of treatment. For eggs: 1 day from the cessation of treatment.

SPECIAL PRECAUTIONS FOR STORAGEKeep away from reach and sight of children! Store in original packaging, at temperature between 15 - 25o C, protec-ted from moisture and direct sunlight. Shelf life of the veterinary medicinal product as packaged for sale: 2 years. Shelf life after dilution in drinking wa-ter, according to directions: 24 hours.

25

mg Colidem 50 / kg body weight/day x mean body weight of animals to be treated (kg) mg Colidem 50

/ liter of waterMean daily water consumption (liter) / animal

=

In drinking water:

• Easy to mix• Excellent price quality ratio


DOXIDEM 50Water soluble powder for pigs and poultry

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26

NAME OF THE VETERINARY MEDICINAL PRODUCTDOXIDEM 50, water-soluble powder, 500 mg/g doxycycline hyclate, for pigs and poultry.

STATEMENT OF THE ACTIVE SUBSTANCE AND OTHER INGREDIENTS: 1 gram DOXIDEM 50 contains: Doxycycline hyclate 500 mg (equivalent to 450.50 mg doxycycline base), Excipient (lactose mono-hydrate) qs ad. 1 g

INDICATIONSIn pigs: Doxidem 50 is indicated for treatment of respiratory, digestive and urogenitaly infections caused by susceptible strains of bacteria: Bacillus, Corynebacte-rium, Erysipelothrix, Listeria, Streptococcus, Actinobacillus, Bordetella, Francisella, Hae-mophillus, Pasteurella, Manhaemia, Campy-lobacter, Leptospira, Lawsonia intracellularis, Actinomyces, Fusobacterium, Mycoplasma, Chlamydia, Rickettsia.In poultry: Doxidem 50 is indicated for treatment of respiratory and digestive infec-tions caused by susceptible strains of bacte-ria: Escherichia coli, Corynebacterium, Erysipelothrix, Listeria, Streptococcus, Actino-bacillus, Bordetella, Francisella, Haemophi-llus, Pasteurella, Campylobacter, Borellia, Actinomyces, Fusobacterium, Mycoplasma, Chlamydia, Rickettsia and Anaplasma spp.

CONTRAINDICATIONSDo not use in animals with known hyper-sensitivity to tetracyclines.


DOSAGE FOR EACH SPECIES, ROUTE(S) AND METHOD OF ADMINISTRATIONIn poultry: by oral route the therapeutically dose is 20-40 mg Doxidem 50 (10-20 mg doxycycline/kg body weight/da), adminis-tered for 5 consecutive days.In pigs: by oral route the therapeutically dose is 220-40 mg Doxidem 50 (10-20 mg

doxycycline/kg body weight/day), admin-istered for 5 consecutive days. Based on the recommended doses and the number and weight of the animals to be treated, the exact daily amount of DOXIDEM 50 should be calculated according to the following formula:

ADVICE ON CORRECT ADMINISTRATIONDuring treatment, the animals should drink only medicated water. To ensure a correct dosage, body weight should be determined as accurately as possible to avoid underdos-ing. The use of suitable calibrating weighing equipment is recommended if part packs are used. The daily amount is to be added to the drinking water such all medication will be consumed in 24 hours. Medicated drinking water should be freshly prepared every 24 hours.

WITHDRAWAL PERIODPigs: Edible tissues: 10 days after cessation of oral medication.Poultry: Edible tissues: 7 days after cessation of oral medication.Not permitted for use in laying birds producing eggs for human consumption.

SPECIAL PRECAUTIONS FOR STORAGEKeep away from reach and sight of children! Shelf life of the veterinary medicinal product as packaged for sale: 2 years. The product should be stored in original packaging at temperatures bellow 250C, protected from direct sunlight and freeze. Shelf life after dilution in drinking water, according to directions: 24 hours.

27

mg Doxidem 50 / kg body weight/day x mean body weight of animals to be treated (kg)

mg Doxidem 50 / liter of waterMean daily water consumption (liter) / animal

=

In drinking water:

• Easy to use even with dosing pumps

• High concentration in active ingredients

• An excellent alternative tool against susceptible pathogens


LINCODEM 50Water-soluble powder for pigs and poultry

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28

LINCODEM 50

NAME OF THE VETERINARY MEDICINAL PRODUCTLINCODEM 50, as lincomycin HCl 500 mg/g, powder for administration via drinking water or feed for poultry and pig.

STATEMENT OF THE ACTIVE SUBSTANCE(S) AND OTHER INGREDIENTS1 gram LINCODEM 50 contains:Lincomycin HCl ……………... 500 mg (equivalent to 434,78 mg lincomycin – as base –)Excipient qs. ad. ………..... 1 g

INDICATIONSIn poultry the product is indicated for treatment and control of bacterial infec-tions caused by susceptible bacteria from genera: Gram-positive anaerobs (Clos-tridium spp., Bacteroides spp., Fusobacte-rium spp.) and aerobs (Staphylococcus spp., Streptococcus spp., Bacillus spp., Erysipelo-thrix rhusiopathiae), Actinobacillus spp. some species of Actinomyces, Nocardia and Bordetella, most of Mycoplasma species.In pig: Streptococcus spp., Bacillus spp., Erysipelothrix rhusiopathiae, Actinobacillus spp. some species of Actinomyces, Nocardia and Bordetella, most of Mycoplasma species.

CONTRAINDICATIONS Do not use in animals with known hyper-sensitivity to lincomycin or the excipient.

TARGET SPECIESPoultry and pig.

DOSAGE FOR EACH SPECIES, ROUTE(S) AND METHOD OF ADMINISTRATIONIn poultry: the product is administered by oral route, via drinking water, in dos-age of 30-40 mg Lincodem 50/kg body weight/day, for 7 consecutive days.In pigs: the product is administered by oral route, in dosage of 30-40 mg Lincodem 50/kg body weight/day, for 7 consecutive days.

Based on the recommended doses and the number and weight of the animals to be treated, the exact daily amount of LINCODEM 50 should be calculated ac-cording to the following formula:

ADVICE ON CORRECT ADMINISTRATIONDuring treatment, the animals should drink only medicated water.

WITHDRAWAL PERIODEdible tissues of poultry: 4 days after cessation of oral medication.Eggs: 4 days after cessation of oral medication.Edible tissues of pig: 4 days after cessation of oral medication.

SPECIAL PRECAUTIONS FOR STORAGEIn original packaging, at temperature below 250C, protected from moisture and direct sunlight.Keep out of the reach of children!

29

mg LINCODEM 50/ kg body weight/day x mean body weight of animals to be treated (kg)

mg LINCODEM 50 per liter of

drinking waterMean daily water consumption ( liter ) / animal=

In drinking water:

• Excellent prevention in respiratory syndromes with bacterial origin

• A good choice in Mycoplasma control in poultry & pig

• A useful tool in the field


OXIDEM 50Powder for pigs, poultry and fish

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NAME OF THE VETERINARY MEDICINAL PRODUCT: OXIDEM 50, 500 mg oxytetracicline hydrochloride /g, powder for pigs, poultry and fish.

STATEMENT OF THE ACTIVE SUBSTANCE(S) AND OTHER INGREDIENTS: 1 gram OXIDEM50 contains: Oxytetracicline hydrochloride 500 mg (equivalent to 463 mg oxytetracicline – as base –), Excipient (lactose monohydrate) qs. ad. 1 g

INDICATIONSIn pigs: Oxidem 50 is indicated for the treatment of gastrointestinal and respiratory infections caused by susceptible bacteria of the genera: Mycoplasma spp., Pasteurella spp., Actinobacillus spp., Haemophilus spp., Campylobacter spp. (Lawsonia intracellularis), Erysipelothrix spp., Leptospira spp., Listeria spp., Streptococcus spp. si Fusobacterium spp. In poultry: Oxidem 50 is indicated for the treatment of gastrointestinal and respiratory infections caused by susceptible bacteria of the genera: Mycoplasma spp., Pasteurella spp., Streptococcus spp., Haemophilus spp., Borellia spp., Campylobacter spp. and Chlamydia spp.In fish: for treatment of bacterial disease produced by oxytetracycline-susceptible strains of Aeromonas salmonicida, Aeromonas liquefaciens, Haemophilus piscium, Flavobacterium columnare, Pseudomonas fluorescens, Yersinia ruckeri.

CONTRAINDICATIONS: Do not administer to animals with known hypersensitivity to tetracyclines. Do not administer to animals with renal failure. TARGET SPECIES: Pigs, poultry and fish.

DOSAGE FOR EACH SPECIES, ROUTE(S) AND METHOD OF ADMINISTRATIONIn poultry: In water the dosage is 300-400 g OXIDEM 50 / 1000 L of water, administered for 3-5 consecutive days.In pigs: therapeutically dosage in feed is 20-40 mg OXIDEM 50/ kg body weight / day administered for 3-5 consecutive days or 400 – 600 g OXIDEM 50 / 1000 kg feed , for 3-5 days.In fish: the therapeutically dosage is 8 – 12 g OXIDEM 50 / 100 kg body weight for 4-8 days. The product is administered via feed. For youngsters, mix together 40 g Oxidem 50 with 50 kg of feed and administer continuously for 4-8 days. Based on the recommended doses and the number and weight of the animals to be treated, the exact daily amount of Oxidem 50 should be calculated according to the following formula:

ADVICE ON CORRECT ADMINISTRATION: During treatment, the animals should drink only medicated water.

WITHDRAWAL PERIOD: For meat and offals (pigs, poultry): 28 days days after the last treatment. For fish meat: 60 days for temperatures above 120C and 80 days for the temperature bellow 120C. For eggs: 7 days after the last treatment.

SPECIAL PRECAUTIONS FOR STOR-AGE: In original packaging, at room temperature (15–250C), protected from moisture and direct sunlight. Keep away from reach and sight of children!

31

mg Oxidem 50 / kg body weight/day x mean body weight of animals to be treated (kg) mg Oxidem 50

/ kg feedMean daily feed consumption (kg) / animal

=

In drinking water:

• High a.i. concentration• Active against a wide

range of pathogens• 100% compliance with E.

Ph. 6 specifications


TIADEM 80Water soluble powder for pigs and poultry

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32

COMPOSITIONTiamulin H fumarate…………800 mgExcipient (lactose) qs. ad. …………1 g

INDICATIONSIn poultry is indicated for the treatment and control of Chronic Respiratory Disease, avian mycoplasmosis caused by M. gallisepticum and M. synoviae and also against other infections caused by susceptible bacteria (Clostridium spp, Staphylococcus etc).In pigs is indicated for the treatment and control of infections caused by Brachispira (Serpulina) hyodisenteriae, Brachispira pilosicoli, Lawsonia intracellularis, M. hyopneumoniae and M. hyosinoviae and also against other infections caused by susceptible bacteria (Clostridium spp, Staphylococcus etc).

CONTRAINDICATIONSDo not administer to animals susceptible to tiamulin. Animals should not receive products containing ionophores (monensin, narasin or salinomycin) during or for at least seven days before or after treatment with tiamulin. Severe growth depression or death may result.

ADVERSE REACTIONSLocal (digestive) and systemic reactions are infrequently and transient. In pigs, in some animals, erythema was noticed.

TARGET SPECIES: Poultry and pigs.

DOSAGE FOR EACH SPECIES, ROUTE(S) AND METHOD OF ADMINISTRATIONIn pigs: the product is administered via drinking water in dosage of 12 mg Tiamulin 80%/kg body weight/day (equivalent with 10mg tiamulin H fumarate/kg bw), for 5 consecutive days.In poultry: the product is administered via drinking water in dosage of 25 mg

Tiamulin 80%/kg body weight/day (20 mg tiamulin H fumarate/kg bw) administered for 5 consecutive days.Related with disease evolution, the veterinarian doctor may decide prolonging the treatment.Based on the recommended doses and the number and weight of the animals to be treated, the exact daily amount of TIADEM 80 should be calculated according to the following formula:

The uptake of medicated water is dependant on the clinical condition of animals. In order to obtain the correct dosage, the concentration in drinking water may have to be adjusted.

ADVICE ON CORRECT ADMINISTRATIONDuring treatment, animals must drink only medicated water.

WITHDRAWAL PERIODEdible tissues of pigs: 9 days after cessation of oral medication.Edible tissues of poultry: 7 days after cessation of oral medication.Eggs: 8 days after cessation of oral medication.

SPECIAL WARNINGSUse of the product should be based onsusceptibility testing of the bacteria isolated from the animal. If this is not possible,therapy should be based on local (regional,farm level) epidemiological informationabout susceptibility of the target bacteria.People with known hypersensitivity to any of the product ingredients should avoid contact with the veterinary medicinal product.

33

mg TIAMULIN 80% / kg body weight/day x mean body weight of animals to be treated (kg)

mg TIAMULIN 80% / liter of

drinking waterMean daily water consumption (kg) / animal=

• Prevention and Treatment of chro ic respiratory disease in poultry (CRD) and air sacculitis

• The first choice in Mycoplasma control in poultry and pigs

• Main elected antibiotic for Swine Disenteria with Brachispira and against Illeitis

• Proven efficacy in the field

TIADEM 80


TILODEM 50Water soluble powder for pigs and poultry

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34

NAME OF THE VETERINARY MEDICINAL PRODUCTTILODEM 50 water soluble powder, 500 mg tilosin tartrate /g, powder for pigs and poultry

STATEMENT OF THE ACTIVE SUBSTANCE AND OTHER INGREDIENTS1 gram of Tilodem 50 contains: Tilosin tartrate ………..…… 500 mg (equivalent to 430 mg tilosin base) Excipients (lactose monohydrate) qs.ad....... 1 g

INDICATIONSTilodem 50 is used for local and systemic action, representing an intervention antibiotic when penicillin-resistant microbial strains occurred. It is recommended for pigs and poultry to treat primary or secondary infection, local or systemic produced by pathogens sensitive to tylosin: treatment of enzootic pneumonia on swine, chronic respiratory disease in poultry, enteritis, bronchopneumonia, metritis, pyoderma, urinary infections, mastitis, arthritis, omphalophlebitis, salpingitis

CONTRAINDICATIONSDo not give to animal with known hypersensitivity to tilosin or other macrolides.

TARGET SPECIESPigs and poultry

DOSAGE FOR EACH SPECIES, ROUTE(S) AND METHOD OF ADMINISTRATIONIn poultry: the product is administered oral, in dosage of 30-40 mg tilosin/kg bw/

day (75 – 100 mg Tilodem 50 /kg bw/day), for 4-5 consecutive days.In pigs: the product is administered in dosage of 25-30 mg tilosin /kg bw/day (62,5 – 75 mg Tilodem 50/kg bw/day), for 4-5 consecutive days.Based on the recommended doses and the number and weight of the animals to be treated, the exact daily amount of Tilodem 50 should be calculated according to the following formula:

Throughout the treatment, animals should drink only medicated water. Every 24 hours is prepared fresh medicated water.

WITHDRAWAL PERIODSwine meat and offal: 10 days from cessa-tion of tratamentPoultry meat and offal: 4 days from cessation of tratamentFor eggs: from cessation of tratament

SPECIAL PRECAUTIONSFOR STOR AGEKeep away from reach and sight of children!Store in original packaging, at roomtemperature (bellow 250C), protected from moisture and direct sunlight.Shelf life of the veterinary medicinalproduct as packaged for sale: 2 years.After first opening the container productuse immediately.Shelf life after dilution in drinking water,according to directions: 24 hours.

35

=

mg Tilodem 50/ kg body weight/day x mean body weight of animals to be treated (kg) mg Tilodem 50 /

kg feedMean daily feed consumption (kg) / animal

=

In drinking water:• The first choice in Mycoplasma

control in poultry and pigs• High concentration: KD effect• Specific cellular mechanism of action

Premix

AMOXIDEM 10%100 mg/g, premix for medicated feed for pigs and poultry

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36

STATEMENT OF THE ACTIVE SUBSTANCE(S) AND OTHER INGREDIENTSAMOXIDEM 10% PREMIX is a white-ye-llowish powder that contains per 1 gram:Amoxicillin trihydrate ... 100 mg (equivalent to 87 mg amoxicillin as base)Excipient (corn starch) up to...1 g

INDICATIONSIn pigs: AMOXIDEM 10% PREMIX is used for treatment and control of infections produced by susceptible bacteria from genera: Staphylococcus, Streptococcus, Corynebacteri-um, Clostridium, Salmonella, Escherichia coli, Klebsiella, Pasteurella, Erysipelothrix rhusiopa-tiae, Haemophilus, Brucella, Fusobacterium, Bacillus, Serpulina (Brachispira) hyodisente-riae and Leptospira. In poultry: for treatment and control of infections produced by susceptible bacteria from genera: Staphylococcus, Streptococ-cus, Corynebacterium, Clostridium, Salmo-nella, Escherichia coli, Klebsiella, Pasteurella, Haemophilus, Erysipelothrix rhusiopatiae, Fusobacterium, Bacillus and Borellia

CONTRAINDICATIONS Do not administer to animals with known hypersensitivity to penicillins, beta-lactams and cephalosporins.The product must not be administered in small rodents such as hamsters, Guinea pigs, rabbits, chinchillas. The amoxicillin is altering the intestinal microflora of these animals leading to lethal enterocolitis.

ADVERSE REACTIONSA common side effect of antibiotics is dia-rrhea, which may be caused by the elimina-tion of beneficial bacteria normally found in the colon.Rarely, some animals may develop hypersen-sitivity reactions. In such cases, remove the medicated feed or water and treat the animals by administering of anti-allergic medications (antihistamines, adrenaline, corticosteroids).


DOSAGE FOR EACH SPECIES, ROUTE(S) AND METHOD OF ADMINISTRATIONAMOXIDEM 10% PREMIX is administered via feed in the following dosages: In poultry: mix with feed to ensure a dosage of 230 mg AMOXIDEM 10 % PREMIX/kg bw/day and administer for 5 consecutive days. In pigs: mix with feed to ensure a dosage of 230 mg AMOXIDEM 10 % PREMIX/kg bw/day and administer for 5 consecutive days.Based on the recommended doses and the number and weight of the animals to be treated, the exact daily amount of AMOXI-DEM 10% PREMIX should be calculated according to the following formula:

The uptake of medicated feed is dependant on the clinical condition of animals. In order to obtain the correct dosage, the concentration in feed may have to be adjusted. The use of suitable calibrating weighing equip - ment is recommended if part packs are used.

ADVICE ON CORRECT ADMINISTRATIONDuring treatment, the animals should eat only medicated feed. To ensure a correct dosage, body weight should be determined as accurately as possible to avoid underdosing. The use of suitable calibrating weighing equipment is recommended if part packs are used. The product should be well mixed with the feed to be homogenous.

WITHDRAWAL PERIODPigs, poultry: 28 days after cessation of oral medication. Not permitted for use in laying birds producing eggs for human consumption.

SPECIAL PRECAUTIONS FOR STORAGEKeep away from reach and sight of children!Shelf life of the veterinary medicinal product as packaged for sale: 2 years. Keep in original packaging, at temperature below 250C, protected from direct sunlight and moisture. After opening the package the product should be used entirely. Shelf life after incorporation into meal: 7 daysDo not use after expiry date which is stated on the label.

37

mg Florfenidem 50 / kg body weight/day x mean body weight of animals to be treated (kg) mg Florfenidem 50 /

kg feedMean daily feed consumption (kg) / animal=

• Wide spectrum in livestock species

• High rate of effectiveness

AMOXIDEM 10%

Premix

CLORTETRADEM 10%Premix for medicated feed, 100 mg/g chlortetracycline HCl,

for pigs and poultry (chickens, turkeys)

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38

STATEMENT OF THE ACTIVE SUB-STANCE AND OTHER INGREDIENTS1 gram CLORTETRADEM 10% PREMIX contains:Chlortetracycline HCl... 100 mg Excipient (corn starch) qs ad. ... 1 g INDICATIONSIn pigs: CLORTETRADEM 10% premix is indicated for treatment and control of respiratory and systemic infections associated with organisms chlortetracycline-susceptible: Haemophillus parasuis, Corynebacterium, Ery-sipelothrix rhusiopatiae, Streptococcus hyicus, Actinobacillus pleuropneumoniae, Pasteurella multocida, Mycoplasma spp. etc.In poultry (chickens, turkeys): CLORTE-TRADEM 10% premix is indicated for treat-ment and control of respiratory and systemic infections associated with organisms sensitive to chlortetracycline-susceptible: Streptococcus spp., Bordetella bronchiseptica, Haemophillus paragallinarum, Pasteurella multocida, Fuso-bacterium, Mycoplasma, Chlamydia, etc. CONTRAINDICATIONSDo not use in animals with known hypersen-sitivity to tetracyclines. ADVERSE REACTIONSIn some cases, the animal with severe renal failure could develop adverse reactions characterized by: anorexia, vomit, diarrhea, abdominal colic, painful defecation. The possible toxic phenomena are due to chlortetracycline high concentrations in blood and tissues, which occur after the administration of multiple high doses and in low intervals or in case of severe renal failure. Digestive apparatus: anorexia, vomits, diarrhea, abdominal colic and pancreatitis; administered for long periods of time can produce staphylococcal enteritis or candido-sis (oral, intestinal, pulmonary).Teeth: dental pigmentation, caries and dental enamel hypoplasia in suckling and young off-springs to who mothers were treated with CLORTETRADEM 10% premix in the latest period of gestation or after birth.

TARGET SPECIESPigs and poultry (chickens, turkeys).

DOSAGE FOR EACH SPECIES, ROUTE(S) AND METHOD OF ADMINISTRATIONCLORTETRADEM 10% premix is admi-nistered via drinking water in the following dosages: Pigs: 110 mg CLORTETRADEM 10% premix /kg b.w./day administered for 5 consecutive days.Poultry (chickens, turkeys): 110 mg CLOR-TETRADEM 10% premix /kg b.w./day, administered for 5 consecutive days.Based on the recommended doses and the number and weight of the animals to be treated, the exact daily amount of CLOR-TETRADEM 10% PREMIX included in feed should be calculated according to the follo-wing formula:

The uptake of medicated feed is dependant on the clinical condition of animals. In order to obtain the correct dosage, the concentra-tion in feed may have to be adjusted. The use of suitable calibrating weighing equipment is recommended if part packs are used.

ADVICE ON CORRECT ADMINISTRATIONDuring treatment, the animals should eat only medicated feed. To ensure a correct dosage, body weight should be determined as accurately as possible to avoid underdosing.

WITHDRAWAL PERIODPigs, poultry (chickens, turkeys):Edible tissues: 28 days after cessation of oral medication. For eggs: 7 days after cessation of oral medication

SPECIAL PRECAUTIONS FOR STORAGEKeep away from reach and sight of children!Store in original packaging at temperatures below 250C, protected from moisture and direct sunlight. Shelf life of the veterinary me-dicinal product as packaged for sale: 2 years. Shelf life after dilution in drinking water, ac-cording to directions: 24 hours. Shelf life after first opening of the package: 7 days. Shelf life after incorporation into meal: 7 days. Do not use after expiry date which is stated on the label.

39

mg CLORTETRADEM 10% premix / kg body weight/day x mean body weight of animals to be

treated (kg) mg CLORTETRADEM 10% premix / kg of feed

Mean daily feed consumption (kg) / animal=


• An antibiotic that is coming back to foreground

CLORTETRADEM 10%

Premix

COLIDEM 10%100 mg/g, colistin sulphate,

premix for medicated feed for pigs and poultry

www.delosmedica.com

40

STATEMENT OF THE ACTIVE SUBSTANCE(S) AND OTHER INGREDIENTSCOLIDEM 10% PREMIX is a white pow-der that contains per 1 gram:Colistin sulphate ... 100 mg (minimum 19500 IU/mg)Excipient (corn starch) up to ... 1 g

INDICATIONSIn pigs and poultry: For treatment and metaphylaxy of intestinal infections caused by non-invasive colistin-suscepti-ble strains of E. coli.

CONTRAINDICATIONS Do not administer in animals with known hypersensitivity to polymixines. ADVERSE REACTIONSNone.


DOSAGE FOR EACH SPECIES, ROUTE(S) AND METHOD OF ADMINISTRATIONCOLIDEM 10% PREMIX is administered via feed in the following dosages: In pigs: the product is administered in feed at the therapeutically dosage of 2-5 mg colistin sulphate /kg bw/day, equiva-lent with 20 – 50 mg COLIDEM 10% pre-mix/kg bw/day, for 3-5 consecutive days.In poultry: the product is administered in feed at the therapeutically dosage of 2-5 mg colistin sulphate /kg bw/day, equiva-lent with 20 – 50 mg COLIDEM 10% pre-mix/kg bw/day, for 3-5 consecutive days.Based on the recommended doses and the number and weight of the animals to be treated, the exact daily amount of

COLIDEM 10% PREMIX should be cal - culated according to the following formula:

The uptake of medicated feed is depen-dant on the clinical condition of animals. In order to obtain the correct dosage, the concentration in feed may have to be adjusted. The use of suitable calibrating weighing equipment is recommended if part packs are used.

ADVICE ON CORRECT ADMINIS-TRATIONDuring treatment, the animals should eat only medicated feed. To ensure a correct dosage, body weight should be deter-mined as accurately as possible to avoid underdosing. The use of suitable calibrating weighing equipment is recommended if part packs are used. The product should be well mixed with the feed to be homogenous.

WITHDRAWAL PERIODMeat and offal (pig, poultry): 3 days from cessation of treatment. For eggs: 1 day from the cessation of treatment.

SPECIAL PRECAUTIONS FOR STORAGEKeep away from reach and sight of children! Store in original packaging, at temperature bellow 250C, protected from moisture and direct sunlight. Shelf life of the veterinary medicinal product as packaged for sale: 2 years. Shelf-life after first opening of package: 7 days. Shelf life after incorporation into meal: 7 days Do not use after expiry date which is stated on the label.

41

mg colistin sulphate / kg body weight/day x mean body weight of animals to be treated mg COLIDEM 10%

PREMIX / kg feedMean daily feed consumption (kg) / animal=


• Easy to mix

Premix

ENRODEM 50Enrofloxacin hydrochloride 500 mg/g, premix for medicated

feed for pigs, poultry and fish

www.delosmedica.com

42

NAME OF THE VETERINARY MEDICINAL PRODUCT: ENRODEM 50, 500 mg enrofloxacin hydrochloride/g, premix for medicated feed for swine, poultry and fish.

STATEMENT OF THE ACTIVE SUBSTANCE(S) AND OTHER INGREDIENTS: 1 gram ENRODEM 50 contains: Enrofloxacin hydrochloride 500 mg (equivalent to 453,95 mg enrofloxacin as base), Excipient (lactose monohydrate) qs ad1 g

INDICATIONSFor pigs: for the treatment and control of gastrointestinal, respiratory and urogenitaly infections produced by microorganisms susceptible to enrofloxacin: Gram Negative bacteria (Pseudomonas aeruginosa, Pasteurella spp, Salmonella spp, E.coli, Actinobacillus spp, Shigella, Klebsiella, Campylobacter etc) Gram positive bacteria (Erysipelothrix rhusiopatiae, some strains of Streptococcus and Staphylococ-cus spp. etc), Mycoplasma, Brucella.For poultry: for the treatment and control of gastrointestinal and respiratory infections produced by microorganisms susceptible to enrofloxacin: Gram Negative bacteria (Pseudomonas aeruginosa., Pasteurella spp, Salmonella spp, E.coli, Actinobacillus spp, Campylobacter etc) Gram positive bacteria (some strains of Streptococcus and Staphylo-coccus spp.), Mycoplasma, Chlamydia.For fish: furunculosis, vibriosis, cold water vibriosis, bacterial kidney disease, yersini-osis and other bacterial diseases caused by enrofloxacin -susceptible bacteria.

CONTRAINDICATIONS: Do not use in animals with known hyper-sensitivity to fluoroquinolones. Do no use in pregnant females.

TARGET SPECIES: Pigs, poultry and fish.

DOSAGE FOR EACH SPECIES, ROUTE(S) AND METHOD OF ADMINISTRATIONIn pigs: by oral route, the therapeutically dose is 5 – 10 mg enrofloxacin/Kg bw/day (corre-sponding to 11 - 22 mg Enrodem 50/kg body weight/day) for 5 consecutive days.In poultry: the therapeutically dosage is 5-10 mg enrofloxacin/Kg body weight/day (corresponding to11 - 22 mg Enrodem 50/kg body weight/day) for 5 consecutive days. In infections with Pseudomonas spp. the dosage is 12mg enrofloxacin/kg body weight /day (26,4 mg Enrodem 50/kg body weight) for 5 consecutive days.In fish: 5- 23 mg enrofloxacin/ kg bw fish / day, for 10 consecutive days administered in feed (corresponding to11 – 55,6 mg Enrodem 50/kg bw fish/day). Based on the recom-mended doses and the number and weight of the animals to be treated, the exact daily amount of Enrodem 50 should be calculated according to the following formula:

ADVICE ON CORRECT ADMINISTRATION: During treatment, the animals should eat only medicated feed.

WITHDRAWAL PERIODMeat and offal: 28 days. For fish meat: 12 days for temperatures over 120C, 30 days for temperatures up to 120C. Not permitted for use in laying birds producing eggs for human consumption.

SPECIAL PRECAUTIONS FOR STORAGEIn original packaging, at temperature below 250C, protected from moisture and direct sunlight. Keep out of the reach of children!

43

mg Enrodem 50/ kg body weight/day x mean body weight of animals to be treated (kg) mg Enrodem 50

per kg of feed

Mean daily feed consumption ( kg ) / animal=

In feed:

ENRODEM 50 500 mg/g enrofloxacină clorhidrat

Premix medicamentat pentru suine, păsări (pui de carne, găini de reproducție, tineret înlocuire) şi peşti

Enrofloxacină clorhidrat …………………..……… 500 mg (echivalent cu 453,95 mg enrofloxacină bază)

Excipient (lactoză monohidrat) qs. ad. …………… 1 gFORMA FARMACEUTICĂ: Premix medicamentatMOD ŞI CALE DE ADMINISTRARE: citiţi prospectul înainte de utilizare.

TIMP DE AŞTEPTARE: Carne si organe (porc, pasăre): 28 zile de la ultima administrare.

Carne de peşte: 12 zile la temperatură mai mare de 12oC (240 grade-zile) şi 30 zile la temperatura mai mică de 12oC (360 grade-zile).

Nu se administrează la păsările ale căror ouă sunt destinate consumului uman.

ATENŢIONĂRI SPECIALE: citiţi prospectul înainte de utilizare.CONDIŢII SPECIALE PENTRU DEPOZITARE: A se păstra în ambalajul original, la o temperatură mai mică de 25°C, ferit de umiditate şi

lumina solară directă. După deschiderea ambalajului, produsul se va utiliza imediat.

PRECAUŢII SPECIALE PENTRU ELIMINAREA PRODUSELOR NEUTILIZATE SAU A DEŞEURILOR: produsul sau deşeurile rezultate nu se

aruncă la resturi menajere sau în ape reziduale, ci în locuri special amenajate. Orice produs farmaceutic veterinar neutilizat sau deşeu provenit

din utilizarea unor astfel de produse trebuie eliminate în conformitate cu cerinţele locale.

Produsul Enrodem 50 se eliberează numai pe bază de prescripţie medicală.

A nu se lăsa la îndemâna copiilor!

Autorizaţie de comercializare nr. 130064 Dimensiunea ambalajului: Data expirării: Seria:


• High rate of effectiveness• Suitable for fish farms

Premix

FENBADEM 10%100 mg/g, fenbendazol, premix for medicated feed for pigs,

cattle and sheep

www.delosmedica.com

44



STATEMENT OF THE ACTIVE SUB-STANCE(S) AND OTHER INGREDIENTSFENBADEM 10% PREMIX is a white powder that contains per 1 gram:Fenbendazole ... 100 mg Excipient (corn starch) up to ... 1 g

INDICATIONSIn pigs: the product is recommended for the prevention and treatment of Trichinella spiralis (high efficacy) infestation and for other nematode infestations: Ascaris suum, Oesophagostomum dentatum, Trichuris suis, Stephanurus dentatum and Metastrongylus elongatus and some cestodes Diphilobothrium spp.In cattle and sheep: the product is used for the prevention and treatment of seve-ral nematodes infestations: Haemonchus spp., Ostertagia spp., Trichostrongylus spp., Marshallagia spp., Cooperia spp., Nematodi-rus spp., Bunostomum spp, Chabertia spp., Oesophagostomum spp., Strongyloides spp. and cestodes: Moniedaya spp., Avitelina spp., Thisaniedaya spp., Stilesia spp.

CONTRAINDICATIONS: None.

ADVERSE REACTIONS: None.

TARGET SPECIES: Pigs, cattle and sheep.

DOSAGE FOR EACH SPECIES, ROUTE(S) AND METHOD OF ADMINISTRATIONThe product is administered via feed in the following dosages:Pigs: for the treatment of trichinelosis the product is administered in dosage of 75 mg FENBADEM 10% premix/kg body weight, for 14 consecutive days. For the treatment of other round worm infestation the product is administered in dosage of 75 mg FEN-BADEM 10% premix/kg body weight, for 3 consecutive days, repeating the treatment once more after 14-21 days. For the treatment of Stephanurus dentatum infestation and also for cestodes infestation, the product is admi-nistered in dosage of 100 mg FENBADEM 10% premix /kg body weight, for 3 consecu-tive days, repeating the treatment once more after 14-21 days.

Cattle and sheep: For treatment of round worm infestation, the product is administered as brewage or via feed in dosage of 75 mg FENBADEM 10% premix/kg body weight, for 3 consecutive days. For treatment of cestodes infestations, the product is adminis-tered in dosage of 100 mg FENBADEM 10% premix/kg body weight, for 3 days, repeating the treatment once more after 14-21 days.

Based on the recommended doses and the number and weight of the animals to be treated, the exact daily amount of FENBA-DEM 10% PREMIX should be calculated according to the following formula:

The uptake of medicated feed is dependant on the clinical condition of animals. In order to obtain the correct dosage, the concentration in feed may have to be adjusted.

ADVICE ON CORRECT ADMINISTRATIONDuring treatment, the animals should eat only medicated feed. To ensure a correct dosage, body weight should be determined as accurately as possible to avoid underdo-sing. The use of suitable calibrating weighing equipment is recommended if part packs are used. The product should be well mixed with the feed to be homogenous.

WITHDRAWAL PERIODEdible tissues: 28 days after cessation of oral medication. For milk: 7 days after cessation of oral medication.

SPECIAL PRECAUTIONS FOR STORAGEKeep away from reach and sight of children!Store in original packaging at temperatures be-low 250C, protected from moisture and direct sunlight. Shelf life of the veterinary medicinal product as packaged for sale: 2 years. Shelf life after dilution in drinking water, accord-ing to directions: 24 hours. Shelf life after first opening of the package: 7 days. Shelf life after incorporation into meal: 7 days. Do not use after expiry date which is stated on the label.

45

mg FENBENDAZOL 10% PREMIX / kg body weight/day x mean body weight of animals to

be treated

mg FENBENDAZOL

10% PREMIX / kg feedMean daily feed consumption (kg) / animal

=

FENBANDEM 10%Fenbendazol ..........100 mg . g.

Premix

FLORFENIDEM 50Premix for medicated feed for pigs, poultry and fish

www.delosmedica.com

46

NAME OF THE VETERINARY MEDICINAL PRODUCT FLORFENIDEM 50, premix for medicated feed for pigs, poultry and fish.

STATEMENT OF THE ACTIVE SUBSTANCE(S) AND OTHER INGREDIENTS1 gram FLORFENIDEM 50 contains: Florfenicol 500 mg, Excipient (lactose monohydrate) qs. ad. 1 g

INDICATIONSPoultry: for the treatment of respiratory or digestive infections, primary and secondary caused by Pasteurella multocida, Bordetella bronchiseptica, Salmonella spp., Escherichia coli, Haemophilus spp., Staphylococus spp., Streptococus spp., Ornithobacterium rhinotra-cheale and other microorganisms florfenicol susceptible. Pigs: is recommended for the treatment of re-spiratory or digestive infections, primary and secondary caused by: Pasteurella multocida, Actinobacillus pleuropneumoniae, Bordetella bronchiseptica, Salmonella spp., Escherichia coli, Haemophilus parasuis, Staphylococus spp, Streptococus suis, Mycoplasma spp. and other microorganisms florfenicol susceptible.Fish: furunculosis, vibriosis, yersiniosis and other bacterial diseases produced by bacteria susceptible to florfenicol.

CONTRAINDICATIONSDo not administer to animals susceptible to florfenicol. The product should not be ad-ministered to sows in gestation and lactation period and breeding boars.

TARGET SPECIES Swine, Poultry, Fish.

DOSAGE FOR EACH SPECIES, ROUTE(S) AND METHOD OF ADMINISTRATIONPoultry: the therapeutically dosage is 20 mg

florfenicol/kg body weight/day (equivalent with 40 mg Florfenidem 50/ kg body weight) administered in feed, for 3-5 consecutive days.Pigs: the therapeutically dosage is 40 - 60 mg Florfenidem 50 / kg body weight / day) ad-ministered in feed, for 3-5 consecutive days. For mass treatment: 200-400 g Florfenidem 50 per ton. Fish: Florfenidem 50 is administered mixed with feed, in dosage of 10-20 mg Florfenidem 50/kg fish/day, for 14 consecutive days.

Based on the recommended doses and the number and weight of the animals to be treated, the exact daily amount of Florfeni-dem 50 should be calculated according to the following formula:

In some fish species, the uptake of medicated feed depends on water temperature. In order to obtain the correct dosage, the concentra-tion in feed may have to be adjusted.

ADVICE ON CORRECT ADMINISTRATION The product should be well mixed with the feed to ensure a proper dis - persion. During treatment, the animals should eat only medicated feed.

WITHDRAWAL PERIODPigs (meat and offal): 20 days from cessation of oral medication. Poultry (meat and offal): 2 days from cessation of oral medication. For fish meat: 8 days for temperatures over 100C, 16 days for temperatures up to 100C. Not authorised for use in laying birds produ-cing eggs for human consumption.

47

mg Florfenidem 50 / kg body weight/day x mean body weight of animals to be treated (kg) mg Florfenidem 50 /

kg feedMean daily feed consumption (kg) / animal=


• High rate of effectiveness• Suitable for fish farms

Premix

LINCODEM 10%Premix for medicated feed for pigs and poultry

www.delosmedica.com

48

STATEMENT OF THE ACTIVE SUB-STANCE AND OTHER INGREDIENTS1 gram of LINCODEM 10% premix contains:Lincomycine hydrochloride ... 100 mgExcipient (corn starch) qs. ad. ... 1 g INDICATIONSFor treatment and control of bacterial infec-tions caused by susceptible bacteria from gen-era: Staphylococcus spp., Streptococcus spp., Clostridium spp. (Necrotic enteritis), Bacillus spp., Mycoplasma spp., Fusobacterium spp. and other susceptible microorganisms.

CONTRAINDICATIONSDo not give to animals with known hypersen-sitivity to lincomycin.

ADVERSE REACTIONSNone.


DOSAGE FOR EACH SPECIES, ROUTE(S) AND METHOD OF ADMINISTRATIONMix with feed to ensure a daily dose of 120 mg LINCODEM 10% premix/kg body weight and administer for 7 consecutive days.Based on the recommended doses and the number and weight of the animals to be treat-ed, the exact daily amount of LINCODEM 10% premix should be calculated according to the following formula:

The uptake of medicated feed is dependant on the clinical condition of animals. In order to obtain the correct dosage, the concentra-tion in feed or drinking water may have to be adjusted.


WITHDRAWAL PERIODMeat and offal: 28 days from cessation of oral medication. For eggs: 7 days from the cessation of oral medication.

SPECIAL PRECAUTIONS FOR STORAGEKeep away from reach and sight of children!Store in original packaging, at temperature bellow 250C, protected from moisture and direct sunlight. Shelf life of the veterinary medicinal product as packaged for sale: 2 years. Shelf-life after first opening of package: 7 days. Shelf life after incorporation into meal: 7 daysDo not use after expiry date which is stated on the label.

49

mg Lincomicina 10% premix / kg body weight/day x mean body weight of animals to be treated (kg) mg LINCODEM 10%

premix / kg feedMean daily feed consumption (kg) / animal

=


• Excellent choice in Mycoplasma controll in poultry and swine

Premix

TIADEM 10% Tiamulin hydrogen fumarate 100 mg/g,

premix for medicated feed for pigs and poultry

www.delosmedica.com

50

STATEMENT OF THE ACTIVE SUB-STANCE(S) AND OTHER INGREDIENTS1 gram TIADEM 10% PREMIX contains:Tiamulin H fumarate… 100 mgExcipient (corn starch) qs. ad. .... 1 g

INDICATIONSIn poultry is indicated for the treatment of infections caused by susceptible bacteria of the genera: Staphylococcus, Streptococcus, Co-rynebacterium, Fusobacterium, Clostridium, Mycoplasma, Actinobacillus, Haemophillus, Campylobacter, Chlamydia, Rickettsia, Borel-lia anserina and some strains of Pasteurella. In pigs is indicated for the treatment of infec-tions caused by susceptible bacteria of the genera: Staphylococcus, Streptococcus, Bacillus, Erysipelothrix rhusiopathiae, Corynebacte-rium, Fusobacterium Haemophillus, Brucella, Clostridium, Mycoplasma, Actinobacillus pleuropneumoniae, Haemophillus, Listeria, Campylobacter, Serpulina (Brachispira) hyodisenteriae, Leptospira, Rickettsia and some strains of Pasteurella.

CONTRAINDICATIONS Do not administer to animals susceptible to tiamulin During treatment with TIADEM 10% premix, the animals should not be given feed containing anticoccidial ionophores (monen-syn, narazyn, maduramycin and salinomycin) and no less than 7 days before and after the administration of TIADEM 10% premix.

ADVERSE REACTIONSIn pigs, in some animals erythema was noticed.

TARGET SPECIES: Poultry and pigs.

DOSAGE FOR EACH SPECIES, ROUTE(S) AND METHOD OF ADMINISTRATIONIn poultry: the product is administered via feed in dosage of 64-80 mg TIADEM 10%-premix/kg body weight/day, for 3-5 consecutive days.In pigs: the product is administered via feed in dosage of 64-80 mg TIADEM 10%-pre-mix/kg body weight/day, for 3-5 consecutive days. For treatment of Enzootic Pneumonia,

the dosage is 90mg of product/kg bw/day administered for 5 consecutive days. For treatment of Swine Disentery (Brachispira), the dosage is 100mg of product/kg bw/day administered for 5-7 consecutive days. Based on the recommended doses and the number and weight of the animals to be treated, the exact daily amount of TIADEM 10% PREMIX should be calculated according to the following formula:

The uptake of medicated feed is dependant on the clinical condition of animals. In order to obtain the correct dosage, the concentration in feed may have to be adjusted.

ADVICE ON CORRECT ADMINISTRATIONThe product should be well mixed with the feed to ensure a proper dispersion. During treatment, the animals should eat only medi-cated feed.

WITHDRAWAL PERIODMeat and offal: 28 days from cessation of oral medication.For eggs: 7 days from the cessation of oralmedication.

SPECIAL PRECAUTIONS FOR STORAGEKeep away from reach and sight of children!Store in original packaging, at temperature bellow 250C, protected from moisture and direct sunlight. Shelf life of the veterinary medicinal product as packaged for sale: 2 years. Shelf-life after first opening of package: 7 days. Shelf life after incorporation into meal: 7 days. Do not use after expiry date which is stated on the label.

SPECIAL WARNINGSUse of the product should be based on sus-ceptibility testing of the bacteria isolated from the animal. If this is not possible, therapy should be based on local (regional, farm level) epidemiological information about suscepti-bility of the target bacteria.

51

mg Lincomicina 10% premix / kg body weight/day x mean body weight of animals to be treated (kg) mg LINCODEM 10%

premix / kg feedMean daily feed consumption (kg) / animal

=

• The perfect tool in Mycoplasma controll


Premix

TILODEM 10%Premix for medicated feed for pigs and poultry

www.delosmedica.com

52

STATEMENT OF THE ACTIVE SUB-STANCE AND OTHER INGREDIENTS1 gram of TILODEM 10% premix contains:Tylosin tartrate …. 100 mgExcipient (corn starch) qs. ad. ... 1 g

INDICATIONSIn pigs: for treatment and control of respira-tory infections associated with Mycoplasma hyopneumoniae, Actinobacillus pleuropneu-moniae, Pasteurella multocida, Haemophilus parasuis, Bordetella bronchiseptica and also for other infections produced by tylosin sus-ceptible bacteria such as: Staphylococcus spp., Fusobacterium spp., Erysipelothrix rhusiopa-tiae, Clostridium spp. etc.In poultry: for treatment and control of Chronic Respiratory Disease associated with Mycoplasma gallisepticum. It is also indicated for treatment and control of Infectious Coryza and coadjutant of Infectious sinusitis in turkeys. It has broad activity spectrum act-ing against bacterial infections produced by susceptible bacteria from genera: Staphylococ-cus, Streptococcus, Fusobacterium, Clostridium spp. Mycoplasma synoviae, Chlamydia, Ricke-ttsia, Borellia anserina and Pasteurella spp.

CONTRAINDICATIONSDo not give to animals with known hypersen-sitivity to tylosin or other macrolides.

ADVERSE REACTIONS: None.


DOSAGE FOR EACH SPECIES, ROUTE(S) AND METHOD OF ADMINISTRATIONMix with feed to ensure a daily dose of 80-100 mg TILODEM 10% premix/kg body weight and administer for 4-5 consecutive days.Based on the recommended doses and the number and weight of the animals to be treated, the exact daily amount of TILODEM 10% premix should be calculated according

to the following formula:

The uptake of medicated feed is dependant on the clinical condition of animals. In order to obtain the correct dosage, the concentration in feed or drinking water may have to be adjusted.


WITHDRAWAL PERIODMeat and offal: 28 days from cessation of oral medication. For eggs: 7 days from the cessation of oral medication.SPECIAL PRECAUTIONS FOR STORAGEKeep away from reach and sight of children!Store in original packaging, at temperature bellow 250C, protected from moisture and direct sunlight. Shelf life of the veterinary medicinal product as packaged for sale: 2 years. Shelf-life after first opening of package: 7 days. Shelf life after incorporation into meal: 7 days. Do not use after expiry date which is stated on the label.

SPECIAL WARNINGSPeople with known hypersensitivity to any of the product ingredients should avoid contact with the veterinary medicinal product. To prevent any unpleasant effects, personal pro-tective equipment consisting in rubber gloves, goggles and dust masks should be worn when administering the product.

53

mg TILODEM 10% premix / kg body weight/day x mean body weight of animals to be treated (kg)

mg TILODEM 10% premix / kg feedMean daily feed consumption (kg) / animal

=

• Specific cellular mechanism of action

• High concentration: KD effect

TILODEM 10%

Company contact:

S.C. Delos Impex '96 S.R.L.

81, Horia, Closca si Crisan Street, Otopeni,

Ilfov District, Romania, Tel. +0040-372 714 433

www.delosmedica.com

antibiotics and antiparasiticals. flexible solutions for...

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