anti-inflammatory drugs steroids and nsaids rc 195
TRANSCRIPT
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Anti-Inflammatory Drugs
Steroids and NSAIDs
RC 195
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Corticosteroids, “Steroids”Naturally-occurring hormones produced by the adrenal glands
Glucocorticoids: HydrocortisoneMineralcorticoids: AldosteroneSex Hormones: Testosterone
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Actions of GlucocorticoidsAnti-inflammatory– Supresses actions of kinins, cytokines, and other mediators of inflammation
• Maintains microcirculation and minimizes edema• Maintains cell membrane integrity• Inhibits macrophage movement
Inhibition of immune response– Stabilizes mast cells– Reduces histamine levels
Bronchodilation– Potentiates catecholamine activity by inhibiting COMT and increasing adenyl
cyclase production– Decreased cholinergic and alpha stimulation– Decreased phosphodiesterase production
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Steroid Uses
Acute InflammationOrgan TransplantAllergic Inflammation
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Steroid Side Effects: “Cushing’s Syndrome”
GluconeogenesisOsteoporosisPhysical changes– Increased fat production and
redistribution– Acne– Hirsutism– Fragile skin
Sodium retention– Fluid retention– Potassium loss and metabolic
alkalosis
Increased gastric acidityDecreased resistance to infection– MDI may cause candida
albicans, “thrush”– Patients need to rinse mouth
after MDI
Dependency– Both physical and psychological
• Patients may need to be weaned from steroid therapy
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Interaction with other drugs
Increased breakdown in the presence of:– Dilantin, barbiturates, certain tranquilizers, anti-
histamines, ephedrine
Decreased breakdown (and greater chance of severe side effects) in the presence of some antibiotics, eg erythromycin
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Steroids in Respiratory Care
For prevention of inflammation – aerosol
For relief of inflammation: systemic
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Hydrocortisone
Brand name(s): Solu-Cortef, CortefGiven orally or IVNot usually aerosolized because of side effects
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Prednisone (Prednisolone)
Brand: Deltasone, Delta-Cortef4X as potent as hydrocortisoneGiven orally– Side effects minimized if given every other day– Patient’s usually need to be weaned from it
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Methylprednisolone
Brand: Solu-MedrolOral or IV– Often used to help relieve airway inflammation
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Triamcinolone
Brands: Azmacort, KenalogMDI- to prevent airway inflammation
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Dexamethasone
Brand: DecadronOften nebulized for acute upper airway inflammation– What else is used with it?
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Beclomethasone
Brands: Vanceril, Beclovent, BecotideMDI– to prevent airway inflammation
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Mometasone Furoate
Brand: AsmanexDPI “Twisthaler” 220mcg per pffStarted as one puff per day in then evening and may go as high two puffs BID
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Flunisolide
Brand: AeroBidMDI – to prevent airway inflammationUsually effective when given only BID
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Fluticasone
Brand: FloventMDI (similar to Flunisolide)Fluticasone is also sold as a combo drug, Advair, which contains fluticasone and salmeterol– Taken as a dry powder inhaler (DPI)
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Budesonide
Brand: PulmicortMDI – to prevent airway inflammationSeems to get best effects with minimal side effects
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NSAIDs
Drugs that prevent airway inflammation but usually have less side effects than steroids
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Cromolyn Sodium
Brands: Intal, AaraneIs a mast cell stabilizer so used to prevent airway inflammation– Does not relieve airway inflammation!
Often used as an alternative to aerosol steroids in childrenAdministered via Spinhaler (DPI), MDI, nebulizer– Usually needs to be administered Q.I.D.– May take at least two weeks before any effects are seen
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Nedocromil Sodium
Brand: TiladeSimilar to cromolyn sodium (used to prevent airway inflammation)MDI – usually only needed B.I.D.
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NSAIDs: Leukotriene Inhibitors
(used to prevent airway inflammation)
Zafirlukast (Accolate)– Taken as a pill B.I.D.
Zileuton (Zyflo)– Taken as a pill Q.I.D.
Montelukast (Singulair)– Taken as a pill just once a day
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NSAIDs: Omalizumab (Xolair)
Genetically engineered recombinant humanized monoclonal antibodyBinds to IgE and prevents it from attaching to mast cellsGiven sub-Q 1-2 times per month
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Case Study Time!