annual report july 2013 - june 2014 · 2018-02-02 · medicine & pathobiology* dr. alison...

ANNUAL REPORT JULY 2013 - JUNE 2014

BBDC ANNUAL REPORT 2013-2014 1

CONTENTS

Director’s Report ............................................................................................................................................................................ 2

Vision and Mission ......................................................................................................................................................................... 3

Committees ...................................................................................................................................................................................... 4

Research Programs and Enabling Platforms

Discovery Research Programs ............................................................................................................................................................... 5 Applied Research Programs ................................................................................................................................................................... 6 Enabling Platforms ................................................................................................................................................................................. 8

Membership ..................................................................................................................................................................................... 9

Finances ............................................................................................................................................................................................10

Funding Programs and Funding Decisions

Annual Trainee Awards ........................................................................................................................................................................11 Archie Sopman Diabetes Research and Education Awards 2013 ........................................................................................................11 BBDC-HSRLCE Diabetes and Heart Disease - Research Directed Grants ..............................................................................................12 BBDC-Novo Nordisk Chair in Incretin Biology ......................................................................................................................................12 Charles Hollenberg Summer Studentship Program 2014 ....................................................................................................................13 Diabetes Educator of the Year Award 2013 .........................................................................................................................................13 Graduate Studentships: BBDC-Novo Nordisk Studentships ..................................................................................................................................................14 BBDC-University Health Network Graduate Awards ......................................................................................................................14 Tamarack Graduate Award in Diabetes Research ..........................................................................................................................15 Yow Kam-Yuen Graduate Scholarship in Diabetes Research ..........................................................................................................15 Post-doctoral Fellowships: BBDC Post-doctoral Fellowships and Hugh Sellers Post-doctoral Fellowship ................................................................................15 BBDC Fellowships in Diabetes Care (funded by Eli Lilly Canada) ....................................................................................................15 Reuben & Helene Dennis Scholar in Diabetes Research ......................................................................................................................16 Sun Life Financial Equipment Grants for Diabetes Research ...............................................................................................................16 Sun Life Financial New Investigator Award ..........................................................................................................................................16 Sun Life Financial Pilot and Feasibility Grants ......................................................................................................................................16 Trainee Travel Awards .........................................................................................................................................................................17

Survey of Former BBDC-funded Trainees ..............................................................................................................................18

Educational Activities

Annual Scientific Day ...........................................................................................................................................................................19 BBDC Seminar Series (at City-wide Endocrine Rounds) .......................................................................................................................21 Charles Hollenberg Summer Studentship Program: Weekly Seminar Series and Mini-conference 2014 ...........................................21 Diabetes Update ..................................................................................................................................................................................22 U of T/BBDC Diabetes and Endocrinology Update for Primary Care Practitioners ...............................................................................22

Core Laboratory .............................................................................................................................................................................23

Communications ............................................................................................................................................................................23

Acknowledgements ......................................................................................................................................................................24

Our Supporters ...............................................................................................................................................................................24


DIRECTOR’S REPORT We are pleased to provide a detailed report of the activities of the BBDC over the past year – activities which support the BBDC’s mission to bring together U of T researchers across multiple disciplines to develop novel treatment paths to cure diabetes or prevent its complications, and to identify innovative ways to manage diabetes and improve the lives of those living with the disease. Our main priority has been to train a new generation of diabetes researchers which we continue to do by providing numerous training grants in the form of studentships, postdoctoral fellowships and new investigator grants each year. This past year, we surveyed previous recipients of BBDC fellowships and studentships in an attempt to determine the success of our training programs over the last two to three decades. A brief summary of the survey’s findings with a link to the full survey results is included on page 18 of this annual report. We were happy to learn that approximately two thirds of BBDC trainees who responded to the survey are still engaged in diabetes research, care, and/or education and many of our former trainees have had and continue to have very successful and productive careers in the diabetes field. Other highlights and BBDC accomplishments over the past year have included the following:

Together with the University of Toronto Faculty of Medicine and the Heart and Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research, the BBDC launched a new Diabetes and Heart Disease - Research Directed Grant Program. Two outstanding patient-based research proposals received funding of up to $250,000 each.

A new BBDC website was launched in the fall of 2013 which highlights our discovery and applied research programs.

The BBDC’s Knowledge Translation and Optimizing Care Models applied research program, headed by pharmacist, Dr. Lori MacCallum, has made important advances in assisting pharmacists in their expanded role in the management of individuals living with diabetes. The BBDC Pharmacy Newsletter was launched in November 2013 to update pharmacists and other stakeholders on the latest pharmacy-related Knowledge Translation and Optimizing Care efforts ongoing in the BBDC. Many more exciting new developments are expected this coming year. This program has received generous support from Sun Life Financial, Janssen, Merck, and Takeda.

Another of the BBDC’s applied research programs is our International Diabetes Outreach program, which is testing and implementing diabetes education and management programs in developing countries. We are proud that the BBDC Guyana Diabetes Foot Care project, which has dramatically reduced the rate of lower extremity diabetes-related amputations in Guyana, was the recipient of the 2013 Best Research from a Developing Country Award of the Journal of Wound Care.

The BBDC continues to benefit from a very generous donation from Sun Life Financial for diabetes research, education and care made to the University Health Network. Sun Life Financial commits to providing funds for Pilot Grants, Equipment Grants, New Investigator Award as well as funding for Dr. Lori MacCallum’ s Professorship in Wellness and Diabetes Education

Our members have also achieved significant accomplishments this past year. Most notably, Dr. Daniel Drucker, former BBDC Director, was awarded the highest recognition from the American Diabetes Association by receiving the 2014 Banting Medal for Scientific Achievement Award. Some exciting events and new developments for the 2014/2015 year include the launch of the Diabetes Pharmacists Network, the launch of our Guidebook for Pharmacists on Diabetes Management, the first BBDC-Joslin Diabetes Centre Conference in October 2014, and the Diabetes Update in March 2015. In addition, a number of new grant funding programs have recently been announced such as the Sun Life Financial Impact Challenge Grant – Diabetes in Developing Countries, and the Sun Life Financial Impact Challenge Grant – Education and Knowledge Translation: Emphasis on the Community Pharmacist. More programs will be announced in the near future so stay tuned. The 2013/2014 year was a highly successful year for the BBDC. We are already looking forward to innovations we hope to introduce in 2014/2015, building on our previous success and with our eye on the BBDC mission. Gary F. Lewis, MD, FRCPC Director, Banting & Best Diabetes Centre Professor, Departments of Medicine and Physiology Director, Division of Endocrinology and Metabolism Sun Life Financial Chair in Diabetes Drucker Family Chair in Diabetes Research


OUR VISION As Canada’s leading centre of excellence for innovation in diabetes research, education, and clinical care, we will tangibly impact diabetes prevention and outcomes in Canada and globally.

OUR MISSION We bring together researchers across multiple University of Toronto affiliated disciplines to:

Develop novel treatment paths to cure diabetes or prevent its complications

Identify innovative ways to manage diabetes and improve the lives of those living with the disease

OUR PAST AND PRESENT The BBDC was established in 1978 as an Extra-Departmental Unit of the Faculty of Medicine, University of Toronto with the primary objective of advancing diabetes research, education, and care. We currently offer several studentships, fellowships, grants and other support for qualified individuals involved in diabetes research, education and care at the University of Toronto and its affiliated institutions. In addition, we host several educational events for researchers and diabetes healthcare providers. Just over half of the programs of the BBDC are supported from the income on our endowments. We also receive generous philanthropic and industry support which funds various research programs. PAST DIRECTORS:

Dr. Daniel J. Drucker (2000-2011)

Dr. Bernard Zinman (1993-2000)

Dr. Charles H. Hollenberg (1981-1993)

Dr. Edward A. Sellers (1978-1981) A personal friend of the co-discoverer of insulin, Dr. Charles Best


COMMITTEES (as of June 2014) *University of Toronto Executive Committee

DIRECTOR AND CHAIR: Dr. Gary Lewis, Department of Medicine, Division of Endocrinology & Metabolism, and Department of Physiology*

Dr. Khosrow Adeli, Departments of Biochemistry*, and Laboratory Medicine & Pathobiology*

Dr. Alison Buchan, Vice Dean, Research and International Relations, Faculty of Medicine*

Dr. George Fantus, Department of Medicine, Division of Endocrinology & Metabolism, and Department of Physiology*; BBDC Core Laboratory Director

Dr. Richard Gilbert, Department of Medicine, Division of Endocrinology & Metabolism*

Dr. Tony Lam, Departments of Medicine and Physiology*

Dr. Lorraine Lipscombe, Department of Medicine*, and Department of Health Policy, Management and Evaluation*

Dr. Julia Lowe, Department of Medicine, Division of Endocrinology & Metabolism*

Dr. Bruce Perkins, Department of Medicine, Division of Endocrinology & Metabolism*

Dr. Rene Wong, Department of Medicine, Division of Endocrinology & Metabolism*

Dr. Minna Woo, Department of Medicine, Division of Endocrinology & Metabolism* The governance structure of the BBDC consists of a Director and Executive Committee who ensure that the goals of the Centre are appropriately implemented. The Executive Committee provides leadership and representation for the University of Toronto diabetes research and care community.

Discovery Research Steering Committee

CHAIR: Dr. Gary Lewis, Department of Medicine, Division of Endocrinology & Metabolism, and Department of Physiology*

Dr. Khosrow Adeli, Leader, Nutrients, the Digestive Tract and Diabetes Program

Dr. George Fantus, Leader, Prevention and Therapy of Diabetic Complications Program

Dr. Michael Farkouh, Leader, Diabetes and Heart Disease Program

Dr. Denice Feig, Leader, Diabetes in Pregnancy Study Group

Dr. Tony Lam, Associate Director of Research, BBDC

Dr. Michael Wheeler, Leader, Islet/Stem Cell Biology Program This committee is primarily made up of the leadership of the Discovery Research Programs. Their purpose is to coordinate activities in these programs and promote collaboration between the Discovery Research and Applied Research Programs.

Applied Research Steering Committee

CHAIR: Dr. Gary Lewis, Department of Medicine, Division of Endocrinology & Metabolism, and Department of Physiology*

Dr. Lorraine Lipscombe, Leader, Vulnerable Populations/Population Health Program

Dr. Julia Lowe, Leader, International Diabetes Outreach Program

Dr. Lori MacCallum, Program Director, Knowledge Translation and Optimizing Care Models; Leslie Dan Faculty of Pharmacy*

Dr. Rene Wong, Leader, Continuing Health Education and Professional Development Program and Committee This committee is made up of the leadership of the Applied Research Programs. Their purpose is to coordinate activities in these programs and promote collaboration between the Applied Research and Discovery Research Programs.

Training and Research Excellence Committee

CHAIR: Dr. Tony Lam, Associate Director of Research, BBDC ; Departments of Medicine and Physiology*

Dr. Andrew Advani, Department of Medicine, Division of Endocrinology & Metabolism*

Dr. Richard Bazinet, Department of Nutritional Sciences*

Dr. David Cherney, Department of Medicine, Division of Nephrology*

Dr. Herbert Gaisano, Departments of Medicine* and Physiology*

Dr. Margaret Hahn, Department of Psychiatry*

Dr. Cristina Nostro, Department of Physiology*

Dr. Ravi Retnakaran, Department of Medicine, Division of Endocrinology & Metabolism*

Dr. Jonathan Rocheleau, Institute of Biomaterials and Biomedical Engineering*

Dr. Daniel Winer, Department of Laboratory Medicine and Pathobiology* This committee implements the scientific review of BBDC funding programs, develops the Annual Scientific Day program, and selects speakers for the BBDC Seminar Series.

Continuing Health Education & Professional Development Committee

CHAIR: Dr. Rene Wong, Department of Medicine, Division of Endocrinology & Metabolism*

Mrs. Leigh Caplan, Diabetes Educator, Sunnybrook Health Sciences Centre

Ms. Margaret De Melo, Clinical Dietitian, Toronto Western Hospital

Dr. Jeremy Gilbert, Department of Medicine, Division of Endocrinology & Metabolism*

Mr. Henry Halapy, Diabetes Pharmacist, St. Michael's Hospital

Dr. Lori MacCallum, Program Director, Knowledge Translation and Optimizing Care Model; Leslie Dan Faculty of Pharmacy*

Dr. Phillip Segal, Department of Medicine, Division of Endocrinology & Metabolism* This committee organizes continuing health education in diabetes for the health care team and reviews applications for various BBDC funding programs.


RESEARCH PROGRAMS AND ENABLING PLATFORMS

DISCOVERY RESEARCH PROGRAMS

The BBDC’s five Discovery Research Programs fill critical gaps in finding novel therapies to cure or treat diabetes. In bringing together world class researchers from multiple disciplines, they are focused on taking on highly innovative, high risk research questions. They include research programs that support our strategic priorities of curing diabetes and eliminating diabetic complications. More information on these programs can be viewed on the BBDC’s website www.bbdc.org.

ISLET/STEM CELL BIOLOGY Program Leader: Dr. Michael Wheeler

The Islet Centre provides a platform for researchers from a range of disciplines to study the role of the pancreatic islet cell as a key cause and target for treatment of type-1 and type-2 diabetes mellitus. The Islet Program builds upon existing infrastructure and CFI funding success of the UHN and dynamic collaborations amongst UHN scientists, including the McEwen Centre for Regenerative Medicine, to accelerate research into the prevention and treatment of this disease. The program plays a prominent role in the ability of UHN researchers to uncover molecular and physiological determinants of type 1 and

type 2 diabetes and accelerate the establishment of an unlimited source of insulin-producing pancreatic cells from stem cells that can rapidly be moved to the clinic to treat diabetes. This research program will create a centralized, multi-modal diabetes research facility at the University Health Network (UHN).

NUTRIENTS, THE DIGESTIVE TRACT AND DIABETES Program Leader: Dr. Khosrow Adeli

The research program brings together investigators from a wide-variety of disciplines, including endocrinology, gastroenterology, metabolism, neurobiology, nutrition and physiology. Through the application of cell, molecular and whole organism approaches, in animal models as well as in humans, researchers examine the mechanisms underlying obesity and type 2 diabetes, as well as possible nutritional and therapeutic approaches to treat these diseases. One intestinal hormone of particular interest to members of the research group is the nutrient-stimulated incretin, glucagon-like peptide-1,

which has already been successfully introduced into the clinic for the treatment of type 2 diabetes and which is under investigation for use as an anti-obesity agent. Through integration of their research expertise, and in collaboration with the CFI “3D Centre for studies on Diet, the Digestive Tract and Disease”, members of the platform will further accelerate the progression of basic science discoveries to the application of these findings in patients with obesity and diabetes.

DIABETES AND HEART DISEASE Program Leader: Dr. Michael Farkouh

The program connects multiple scientists and institutions from diverse disciplines/technology platforms to address the most challenging research questions in the prevention and treatment of cardiovascular complications of diabetes. This program’s main goal is to promote a Toronto-based, cross-site, clinical research collaboration on a central core platform. The initial focus will be on clinical trials in the following high impact research areas: diastolic heart failure, coronary artery disease, peripheral arterial disease, and inflammatory biomarkers/novel compounds.

http://www.bbdc.org/


PREVENTION AND THERAPY OF DIABETIC COMPLICATIONS Program Leader: Dr. George Fantus

This program promotes the collaborative research of investigators involved in the field of diabetes complications at the University of Toronto and its fully affiliated academic teaching hospitals and research institutes. Through regular meetings and presentations by participating laboratories, group interactions are fostered and collaborative research granting opportunities are facilitated. The program spans cell biology animal models and human trials featuring a comprehensive and interdisciplinary research program. A major focus of the program is diabetic nephropathy (kidney disease) in which the University of

Toronto has an internationally recognized group of scientists.

DIABETES IN PREGNANCY STUDY GROUP Program Leader: Dr. Denice Feig

This program brings together researchers and clinicians from across the city’s academic centres in order to foster collaboration in research in the area of Diabetes in Pregnancy. The group includes epidemiologists, trialists, health services researchers, translational and basic scientists from the endocrinology and obstetrics fields. The group meets every two months to present completed or ongoing research and to discuss controversial care issues in the area of Diabetes in Pregnancy. In order to take advantage of the large population of women seen by these centres, the group is working to develop a

common database so that future research can utilize the city’s large patient population for collaborative research between sites.

APPLIED RESEARCH PROGRAMS

The four Applied Research Programs span the enormous chasm between the known evidence of what interventions positively impact diabetes, and what occurs in the domain of the practical. Here we bring together incredible assets that already exist in diabetes knowledge translation and population health research in order to accelerate innovations that can markedly improve the lives of those living with diabetes. More information on these programs can be viewed on the BBDC’s website www.bbdc.org.

KNOWLEDGE TRANSLATION AND OPTIMIZING CARE MODELS Program Leader: Dr. Lori MacCallum

The mandate of this program is to ensure that scientific knowledge of what we know constitutes best practice is implemented to improve the lives of people with diabetes. Our primary focus is to examine diabetes care gaps that could best be addressed by pharmacists and develop programs that support and empower pharmacists in the care of patients with diabetes. There are approximately 37,000 pharmacists in Canada, most of whom work in a community setting making pharmacists highly accessible. Approximately 85% of patients with diabetes are taking at least one medication and people with diabetes

will see a pharmacist more often than any other health care provider. Pharmacists are highly trained medication experts and this together with their expanded scope of practice and reimbursement for cognitive services creates an environment where patient-centred care can improve diabetes outcomes. The Knowledge Translation and Optimizing Care Models program recently launched its Guidebook for Pharmacists on Diabetes Management across the country. It also simultaneously launched a national network which is free and open to all licensed pharmacists in Canada with an interest in diabetes. The goal is to bring together pharmacists to share ideas and best practices through events, publications and networking. In 2015, the program will be launching an interactive, online educational program for members allowing them to apply their knowledge through case-based learning. To learn more, visit www.diabetespharmacistsnetwork.ca.


http://www.diabetespharmacistsnetwork.ca/


CONTINUING HEALTH EDUCATION AND PROFESSIONAL DEVELOPMENT

Program Leader: Dr. Rene Wong

Continuing education is a process of lifelong learning for health professionals to expand and fulfill their potential, retain their capacity to practice safely and effectively, and to meet the healthcare priorities of the population and broader health care systems. This program provides continuing health education and opportunities for professional development for all members of the diabetes team. In addition to building individual knowledge and skills, it will also adopt interprofessional education principles to improve collaborative patient-centered care. The BBDC designs its education practices using evidence-based

teaching and learning principles most likely to change practice behaviour.

VULNERABLE POPULATIONS/POPULATION HEALTH Program Leader: Dr. Lorraine Lipscombe

The program expands and strengthens the impact of the knowledge generated by the core group of University of Toronto-based diabetes population health scientists by bringing together front-line clinicians and public health and policy researchers to help frame research questions, and directly shape health policy. Key areas of focus are: 1) Identifying strategies to improve outcomes in socially disadvantaged populations with diabetes or at risk for diabetes; 2) Identifying priorities and building capacity for high quality research in diabetes population health; and 3) Informing changes in clinical practice and health

system policies that affect these populations in Canada.

INTERNATIONAL DIABETES OUTREACH Program Leader: Dr. Julia Lowe

Three quarters of people with diabetes are now living in low-and middle-income countries. In the next 20 years, Africa, the Middle East, and South- East Asia will shoulder the greatest increase in diabetes prevalence. The University of Toronto, in conjunction with Canadian Association of General Surgeons and Canadian International Development Agency (CIDA), has developed a sustainable, integrated, multi-level Diabetes Education, Training, and Capacity Building model to tangibly impact the lives of those living with diabetes internationally. The Guyana Diabetic Foot Project has already resulted in a 50% reduction in

diabetes related major amputations. The project uses proven U of T educational resources such as the International Interprofessional Wound Care Course to train Guyanese key opinion leaders. In partnership with the BBDC, the Global Diabetes Collaboration Initiative plans to attract funding in order to expand these programs into the Caribbean, Sub-Saharan Africa, and the Indian subcontinent and in addition to bring effective strategies back to our own disadvantaged populations in Ontario and in Canada.


ENABLING PLATFORMS

Underpinning the Discovery and Applied research programs are technology and other support platforms that draw upon a broad set of assets within the University of Toronto research community. These platforms will enable the research programs, allowing for maximal potential for impact. More information on these platforms can be viewed on the BBDC’s website www.bbdc.org.

CLINICAL RESEARCH PLATFORM

This platform coordinates, expands, and enhances the impact of Toronto-based clinical trial capacity across each of the priority research areas of focus for the BBDC, with an initial focus on diabetes and heart disease. The BBDC is partnering with the Applied Health Research Consortium (AHRC) at St. Michael’s Hospital to establish a Toronto-based cross-site clinical research collaboration.

INFORMATICS PLATFORM

Ontario is uniquely advantaged for population health research due to its single population database which links multiple administrative and clinical datasets at ICES. However, we do not have a single dataset containing the appropriate clinical information to support population health research, clinical trial recruitment, knowledge translation research, and basic science programs. In partnership with the Applied Health Research Consortium (AHRC) at St. Michael’s Hospital, the BBDC is currently developing plans for an advanced diabetes registry, to support clinical research studies and applied research on health services and policy interventions.

CORE LABORATORY The BBDC Core Laboratory provides high quality laboratory services to diabetes researchers at the University of Toronto involved in clinical and/or basic research. The lab also provides services to the wider scientific community including external academic and/or industry initiated research. The BBDC is expanding its Core Laboratory services to better serve the needs of BBDC researchers and affiliates as the BBDC expands its research enterprise. A steering committee of BBDC members based at Mount Sinai Hospital, The Hospital for Sick Children, and St. Michael’s Hospital have established close collaborations across institutions in order to offer a more complete lab inventory that will greatly support diabetes researchers. Assays and services that go beyond the traditional services of the BBDC core lab will be made available to investigators.

TRAINING AND RESEARCH EXCELLENCE PLATFORM The BBDC is an extraordinary training ground for the diabetes researchers and innovators of the future, offering multiple levels of support for qualified individuals involved in diabetes research, patient care, and education. The current core offering of the BBDC is its broad portfolio of training grants offered to students, postdoctoral fellows, and investigators across a diverse set of disciplines in the University of Toronto and Toronto Academic Health Sciences Network (TAHSN). We will maintain this incredible training program, but will incorporate feedback from the field on how to enhance the program for better impact, community building, and profile-building for the BBDC.



MEMBERSHIP The BBDC membership is a network of individuals involved in diabetes research, education and care from various departments at the University of Toronto and its affiliated hospitals. Membership is free and open to individuals involved in full or part-time diabetes research, education, or patient care (i.e. scientists, physicians, nurses, dietitians, pharmacists, etc.) and whose primary university appointment or employment (i.e. more than 50% of total salary), is with the University of Toronto or one of its affiliated hospitals listed below. The BBDC occasionally makes membership available to non-U of T affiliated faculty and health professionals who are invited by the BBDC to play a major role in the Centre’s activities (e.g. those asked to join BBDC committees or to participate in research programs). Post-doctoral fellows, graduate students, undergraduate students, research associates and assistants, and technicians are not eligible for membership; however, they are welcome to join our e-mail list.

Fully Affiliated Hospitals Community Affiliated Hospitals and Sites

Baycrest

Centre for Addiction and Mental Health

Holland Bloorview Kids Rehabilitation Hospital

Hospital for Sick Children

Mount Sinai Hospital

St. Michael's Hospital

Sunnybrook Health Sciences Centre

University Health Network (includes Princess Margaret Hospital, Toronto General Hospital, Toronto Western Hospital, and Toronto Rehabilitation Institute)

Women's College Hospital

Bridgepoint Health

Credit Valley Hospital

George Hull Centre for Children and Families

Hincks-Dellcrest Centre

Humber River Regional Hospital

Lakeridge Health Network

Markham-Stouffville Hospital

North York General Hospital

Ontario Shores Centre for Mental Health Sciences

Providence Healthcare

The Royal Victoria Hospital

Scarborough Hospital

St. John's Rehabilitation Hospital

St. Joseph's Health Centre

Southlake Regional Health Centre

Surrey Place Centre

Toronto East General Hospital

Trillium Health Centre

West Park Healthcare Centre

Approximately 180 members are registered with the BBDC: 110 are U of T faculty involved in diabetes research and 70 are health professionals involved in diabetes care or education. Members are profiled on our website www.bbdc.org.

BENEFITS OF MEMBERSHIP

Allows individuals to become eligible to apply for the BBDC's funding programs (specific eligibility requirements are outlined for each funding program)

Enables individuals to attend the BBDC's Annual Scientific Day and other events which may be open to members and their trainees only.

Research member's diabetes-related activities and contact information are posted on our website which enables local and foreign trainees to locate potential supervisors at the University, and helps facilitate the development of collaborative diabetes-related activities.



FINANCES (For the year July 1, 2013 to June 30, 2014)

REVENUES

Endowment Income 842,095

Expendable Contributions (from industry, hospital, and university partnerships) 1,064,338

Other (expendable donations, unrestricted educational grants, miscellaneous) 113,053

Total 2,019,486

EXPENSES

Administration (salaries, supplies, equipment, review expenditures, miscellaneous) 522,575

Educational Functions:

BBDC Seminar Series 9,976

Annual Scientific Day 35,400

Knowledge Translation and Optimizing Care Models Program 23,042

International Diabetes Outreach Program 8,800

Funding Programs for Trainees:

Post-doctoral Fellowships 292,834

Graduate Studentships1 297,260

Charles Hollenberg Summer Studentship Program 2014 31,200

Trainee Travel Awards 28,657

Annual Trainee Awards 1,200

Funding Programs for Faculty & Health Care Professionals:

Reuben & Helene Dennis Scholar in Diabetes Research 10,000

BBDC-Heart & Stroke/Richard Lewar Centre Diabetes and Heart Disease Research Directed Grants2 384,338

Sun Life Financial Equipment Grants for Diabetes Research 30,000

Archie Sopman Diabetes Research and Education Awards 20133 11,188

BBDC-Novo Nordisk Chair in Incretin Biology 145,870

Diabetes Educator of the Year Award 2013 1,000

Total 1,833,340

1 Payments are made directly to the award recipients by the Faculty of Medicine, Graduate and Life Sciences Education Office.

2 Payments are made directly to the grant recipients by the Faculty of Medicine, Heart & Stroke/Richard Lewar Centre of Excellence.

3 Payments are made directly to the award recipients by the Toronto General & Western Hospital Foundation.


FUNDING PROGRAMS AND FUNDING DECISIONS Eligibility: The majority of the BBDC's funding programs are only open to members of the BBDC. Specific eligibility requirements for each program are outlined briefly in this report, and in greater detail on our website www.bbdc.org.

ANNUAL TRAINEE AWARDS

Each year graduate, undergraduate, and medical students, post-doctoral and clinical fellows and medical residents are invited to submit an abstract for the Annual Trainee Awards competition. To be eligible, the trainee’s supervisor must hold a full-time faculty appointment with the University of Toronto and must also be a member of the BBDC. The abstract must be directly related to diabetes and the trainee must be first author. The best ten abstracts are selected by the Training and Research Excellence Committee for poster presentation at the BBDC Annual Scientific Day. This year’s posters were co-judged and prize winners selected by Dr. Randy Levinson, Senior Editor of Nature Medicine and Dr. Sreekumaran Nair, Editor-in-Chief of Diabetes. The winners receive gift cards for the University of Toronto Bookstore. The 2013/2014 prize winners are:

Award Recipient Supervisor(s) Abstract Title

1st Prize $400 gift card

Clemence Cote Dr. Tony Lam Novel Mechanism of the Glucose Lowering Effect of Resveratrol

2nd Prize $300 gift card

Dong Ok Son Dr. Qingua Wang The Role of GABA A Receptor Beta3 Subunit in the Regulation of Pancreatic Beta-cell Functions

3rd Prize $200 gift card

Ferhan Siddiqi Dr. Andrew Advani Epigenetic Regulation of Podocyte Oxidative Stress and Renal Injury in Diabetes

Honourable Mention $100 gift card

Alexander Ivovic Dr. Adria Giacca The Roles of NOD Receptors in Beta-cell Function


Cynthia Luk Dr. Minna Woo Disruption of Caspase 8 in Adipose Tissue Protects Mice From Weight Gain and Glucose Intolerance


Erica Pei-Shan Cai Dr. Minna Woo Pivotal Role of Rb and p107 in α- and β-cell Cycle Control and GLP-1 Actions

ARCHIE SOPMAN DIABETES RESEARCH AND EDUCATION AWARDS 2013

This award is only open to University Health Network employees (i.e. employees of Toronto General Hospital, Toronto Western Hospital, or Princess Margaret Hospital). To be eligible, the applicant(s) must be a dietitian, nurse, social worker, pharmacist, staff physician or scientist who is primarily involved in diabetes research, education, or clinical care. The principal applicant must also be a member of the BBDC. Funding can be used for: 1) Travel to a national or international diabetes meeting, or 2) To support a visiting lecturer in diabetes or metabolic disorders. Applications are reviewed by the BBDC’s Director. Funding for this program is provided by the Toronto General and Western Hospital Foundation Archie Sopman endowment fund. The endowment is held at the University Health Network (UHN) and award payments are made directly to the recipients by the UHN. The funding recipients for the 2013 calendar year are:

Recipient Position and UHN Site Purpose Award

Farnouche Alimoradiyan Diabetes Educator Nurse, Endocrinology, Toronto General Hospital

Travel to diabetes meeting Up to $1,000

Karen Biekaitis Registered Dietitian, Toronto General Hospital Travel to diabetes meeting Up to $1,000

Kathryn Camelon Practice Leader, Clinical Nutrition, Toronto General Hospital


Cathy Cohen

Registered Dietitian, Allied Health Clinical Nutrition, Toronto Western Hospital




Margaret De Melo Practice Leader – Clinical Nutrition, Toronto Western Hospital


Hyangjin Im Registered Nurse, Endocrinology, Toronto General Hospital


Doreen Klar Registered Dietitian, Toronto Western Hospital Travel to diabetes meeting Up to $1,000

Kitty Mak Nurse Clinician, Toronto General Hospital


Anne Murphy Dietitian, Endocrinology, Toronto General Hospital


Mary T. Weiland Clinical Dietitian, Toronto Western Hospital Travel to diabetes meeting Up to $200

Martha Wright Nurse Clinician, Diabetes, Toronto General Hospital


Elaine Wylie Clinical Nurse Specialist, Toronto General Hospital


BBDC-HEART & STROKE/RICHARD LEWAR CENTRE OF EXCELLENCE IN CARDIOVASCULAR RESEARCH: DIABETES AND HEART DISEASE - RESEARCH DIRECTED GRANTS

In 2013, the BBDC and the Heart & Stroke/Richard Lewar Centre of Excellence in conjunction with the Vice-Dean, Research and International Relations, Faculty of Medicine established this funding program to support research initiatives focusing on diabetes and heart disease. The purpose of this funding program is to establish the University of Toronto as an international leader in the study of Diabetes and Heart Disease and to foster bench to bedside translational research with a focus on innovation and first-in man clinical trials. To be eligible, the principal applicants must be registered members of either the BBDC and/or the Heart & Stroke/Richard Lewar Centre of Excellence. Applications are reviewed by external reviewers. This funding program is administered by and payments are made to the award recipients by the Heart & Stroke/Richard Lewar Centre of Excellence. The majority of the BBDC's contribution to this program has been generously provided by Sun Life Financial. The following are the 2014, and first funding recipients of this program:

Recipients Primary Research Location

Title of Research Amount

Dr. Ravi Retnakaran (PI) Dr. Candice Silversides Dr. Philip Connelly

Mount Sinai Hospital

A Randomized Controlled Trial to Evaluate Exenatide and Insulin Glargine Combination Therapy for the Preservation of Pancreatic Beta-cell Function and Endothelial Function in Early Type-2 Diabetes

$134,338

Dr. Kim Connelly (PI) Dr. Richard Gilbert Dr. Andrew Advani Dr. Howard Leong-Poi Dr. David Cherney Dr Darren Yuen

St. Michael’s Hospital CD34+ Cell therapy for Diabetic Cardio-Renal Disease $250,000

BBDC - NOVO NORDISK CHAIR IN INCRETIN BIOLOGY

In 2010, the BBDC-Novo Nordisk Chair in Incretin Biology was established at the Banting & Best Diabetes Centre, University of Toronto. The research Chair was made possible through a $3 million gift from Novo Nordisk in appreciation of the innovative diabetes research undertaken by the Centre. Both Novo Nordisk and the University of Toronto, Faculty of Medicine have a long-standing tradition of diabetes research originally dating back to the discovery of insulin, and most recently focused on the science of incretin biology. Dr. Daniel J. Drucker is the inaugural BBDC-Novo Nordisk Chair in Incretin Biology from May 2010 to April 2015.


CHARLES HOLLENBERG SUMMER STUDENTSHIP PROGRAM 2014

This program is designed to introduce young undergraduate and medical students to the field of diabetes research. Each year the BBDC awards up to 15 studentships valued at $4,800 each to qualified undergraduate and/or medical students to carry out full-time summer research in diabetes. To be eligible, the student’s supervisor must hold a full-time faculty appointment with the University of Toronto and must also be a member of the BBDC. The student’s stipend is paid equally by the BBDC and the supervisor. Students are required to participate in the program’s weekly Seminar Series and to present their work at the end of the summer in a workshop format at the Mini-conference (see page 21 for mini-conference program). Applications are reviewed by members of the Training and Research Excellence Committee. The following are the 2014 summer studentship recipients:

Recipient Supervisor(s) Title of Research

Lauren Chan Dr. Darren Yuen Targeting Slit2-Robo Signalling as a Novel Therapy for Diabetic Nephropathy

Giuliana Guarna Dr. Andrew Advani JAK-2 in diabetic nephropathy

David Han Dr. Denise Belsham TNFα induces hypothalamic inflammation and insulin resistance in AgRP/NPY expressing neurons: Reversal with anti-inflammatory agents

Paola Hunter Dr. Patricia Brubaker Circadian pattern of glucagon-like peptide-1 secretion by the human intestinal L cell

Jacalyn Kelly Dr. Khosrow Adeli Pediatric Reference Intervals for Metabolic Disease Biomarkers in Canadian Children and Adolescents

Catherine Lu Dr. James Scholey Acute Kidney Injury in Diabetic Mice: Impact on Kidney Inflammation and Fibrosis

Emily McGaugh Dr. Maria Cristina Nostro Elucidating the role of EGF signaling during pancreatic development using human embryonic stems cells (hESCs) as a model system

Alyssa Molinaro Dr. Derek van der Kooy Pancreatic stem cells from the gut: a new treatment for diabetes

Parmveer Singh Dr. David Irwin Bioinformatic Identification and Analysis of the MLXPIL Gene, the Gene which Encodes Carbohydrate Response-Element Binding Protein (ChREBP)

Darshan Sivaloganathan Dr. Amira Klip How do unsaturated fats turn macrophages anti-inflammatory?

Rebecca Wang Dr. Catherine Yu Assessing the Impact of Animated Comics on Diabetes in Senior Medical Students’ Approach to Patient Interactions

Xinye (Serena) Wang Dr. Michael Wheeler Discovery of novel targets to enhance beta cell function and insulin secretion

Qiwei Yang Dr. Qinghua Wang The Effects of GABA on TNF-α Production from Kupffer Cells in High Fat Diet Fed Mice

DIABETES EDUCATOR OF THE YEAR AWARD 2013

This award recognizes diabetes educators who have demonstrated outstanding efforts and achievements in their role as a diabetes educator. One award is presented each year. To be eligible, the candidate must be a full or part-time diabetes health care professional employed within the boundaries of one of the following Local Health Integration Networks (LHINs): Central LHIN, Central East LHIN, Central West LHIN, Mississauga Halton LHIN, or Toronto Central LHIN. Applications are reviewed by members of the Continuing Health Education & Professional Development Committee. The 2013 award recipient is:

Recipient Profession and Hospital Affiliation Award

Sandra Williams, MEd, RD, CDE, CPT Registered Dietitian, St. Michael’s Hospital $1,000


GRADUATE STUDENTSHIPS

BBDC-Novo Nordisk Studentships

A collaboration with Novo Nordisk Canada Inc. was established in 1996 to provide long-term endowment in support of graduate students who are pursuing a career in diabetes research. As part of the Ontario Student Opportunity Trust Fund program (OSOTF), the support obtained from Novo Nordisk was matched by equal contributions from the University of Toronto and the Government of Ontario for a total endowment of 4.2 million dollars. To be eligible for this award, applicants must be registered with the Faculty of Medicine, School of Graduate Studies at the University of Toronto. The student must demonstrate financial need, and must be carrying out studies in diabetes research. The student’s supervisor must hold a full-time faculty appointment with the University of Toronto and must also be a member of the BBDC. Applications are reviewed by the Training and Research Excellence Committee. Studentships are valued at up to $21,000 each. The following are the 2013/2014 award recipients:

Recipient Supervisor(s) Title of Research

Paymon Azizi Dr. Warren Lee and Dr. Amira Klip

Transcytosis of Insulin Across the Microvascular Endothelium

Kenny Chan Dr. Amira Klip How do macrophages sense saturated fatty acids to become inflammatory?

Adrian I. Cozma Dr. David Jenkins and Dr. John Sievenpiper

Investigating the Effect of Fructose on Glycemic Control and Insulin Sensitivity in Humans Using Meta-Analytical Tools

Sean Froese Dr. Michael Wheeler High-throughput profiling of stem cell derived β cells

Alexander Ivovic Dr. Adria Giacca The roles of β-cell inflammation and ‘β-cell insulin resistance’ in fat-induced β-cell dysfunction

Evan Lewis Dr. Thomas Wolever The Effects of Omega-3 Supplementation on Nerve Structure and Function in Type 1 Diabetes Mellitus – A Clinical Pilot Study

Daiva Nielsen Dr. Ahmed El-Sohemy Disclosure of genetic information and dietary intake behaviour

Courtney Nosak Dr. Allen Volchuk The Role of Jagn1 in Pancreatic Beta cells

Pamuditha Silva Dr. Jonathan Rocheleau and Dr. Dawn Kilkenny

Investigating the mechanisms and dynamics of fibroblast growth factor receptor like 1 (FGFRL1) in pancreatic beta-cells through quantitative fluorescence microscopy

Christopher Villa Dr. Elena Comelli and Dr. Wendy Ward

Utilizing vitamin D to prevent MetS characteristics via nutritional programing in an obesity-stressed murine model

Brian Christopher Wong Dr. Denise Belsham Insulin Signaling in the Hypothalamus: Effects of Insulin Resistance

BBDC-University Health Network Graduate Awards

This graduate award was made possible by the 10-year partnership between the BBDC and the University Health Network. To be eligible for this award, applicants must be registered with the Faculty of Medicine, School of Graduate Studies at the University of Toronto and must be carrying out studies in diabetes research. The student’s supervisor must hold a full-time faculty appointment with the University of Toronto and must also be a member of the BBDC. The student’s supervisor must also hold a full-time UHN appointment as an active staff physician, or if he/she holds an associate staff position or staff scientist position the supervisor's principal laboratory or clinical research space must be physically located at the UHN. Applications are reviewed by the Training and Research Excellence Committee. Awards are valued at up to $21,000 each. The following are the 2013/2014 award recipients:

Recipient Supervisor Title of Research

Mona Abraham Dr. Tony Lam Glucagon action in the Dorsal Vagal Complex

Clémence Côté Dr. Tony Lam Resveratrol action in the duodenum and the regulation of insulin sensitivity

Ronnie Har Dr. David Cherney The Use of Novel Urinary Biomarkers for Early Identification of Patients at risk for Early Cardio-Renal Disease in Patients with Type 1 Diabetes.

Tharini Sivasubramaniyam

Dr. Minna Woo Investigating the role of hepatic JAK2 regulation on atherosclerosis


Tamarack Graduate Award in Diabetes Research

This graduate scholarship was made possible by a generous private endowment which was matched by equal funding from the University of Toronto and the Government of Ontario under the Ontario Student Opportunity Trust Fund program (OSOTF). To be eligible for this award, applicants must be registered with the Faculty of Medicine, School of Graduate Studies at the University of Toronto. The student must demonstrate financial need, and must be carrying out studies in diabetes research. The student’s supervisor must hold a full-time faculty appointment with the University of Toronto and must also be a member of the BBDC. Applications are reviewed by the Training and Research Excellence Committee and preference is given to those students whose primary area of study is vascular problems of diabetes. The award is valued at up to $21,000. The 2013/2014 award recipient is:


Ingrid Dominique Santaren

Dr. Anthony Hanley Association of Dairy Fatty Acid Biomarkers with Insulin Resistance and β-cell Dysfunction

Yow Kam-Yuen Graduate Scholarship in Diabetes Research

This graduate scholarship was made possible by a generous private endowment which was matched by equal funding from the University of Toronto and the Government of Ontario under the Ontario Student Opportunity Trust Fund program (OSOTF). To be eligible for this award, applicants must be registered with the Faculty of Medicine, School of Graduate Studies at the University of Toronto. The student must demonstrate financial need, and must be carrying out studies in diabetes research. The student’s supervisor must hold a full-time faculty appointment with the University of Toronto and must also be a member of the BBDC. Applications are reviewed by the Training and Research Excellence Committee. The value of the award varies depending on endowment income and is normally between $10,000 and $15,000. The 2013/2014 award recipient is:


Tina Binesh Marvasti Dr. Alan Moody The Role of Haptoglobin Polymorphism in Severity of Vascular Disease in Type-2 Diabetes Patients

POST-DOCTORAL FELLOWSHIPS

BBDC Post-doctoral Fellowships and Hugh Sellers Post-doctoral Fellowship

The support of research fellows has been a major priority of the BBDC since the Centre’s inception. Each year, the BBDC endeavours to provide as many fellowships as possible including one Hugh Sellers Post-doctoral Fellowship. The program provides one year of funding for an individual holding an M.D. or Ph.D. who is carrying out full-time diabetes research training at the University of Toronto or one of its fully affiliated institutions. The fellow’s supervisor must hold a full-time faculty appointment with the University of Toronto and must also be a member of the BBDC. Stipends are normally $40,000 or $50,000. Applications are reviewed by the Training and Research Excellence Committee. The following are the 2013/2014 recipients:

Award Recipient Supervisor Title of Research

BBDC Post-doctoral Fellowship

Jamal Daoud (August 2013-March 2014)

Dr. Jonathan Rocheleau

Analysis of Pancreatic Islet FGF21 Secretion Regulated by Fatty Acid Stimulation in a Glucolipotoxicity Model Within a Novel Microfluidic Perifusion and Monitoring Platform


Cynthia Luk Dr. Minna Woo The role of focal adhesion kinase in insulin resistance and adipose tissue remodelling


Cecilia Morgantini Dr. Gary Lewis Role of insulin in apolipoprotein C-III (apoC-III) production in humans

Hugh Sellers Post-doctoral Fellowship

Ming Zhang Dr. Michael Wheeler Discovery of Novel GLP-1R Interactors

BBDC Fellowships in Diabetes Care (Funded by Eli Lilly Canada)

The BBDC Fellowships in Diabetes Care have been made possible by a generous contribution of $120,000 annually from Eli Lilly Canada. This program provides one year of funding for an individual holding an M.D. or Ph.D. who is carrying out full-time diabetes research training at the University of Toronto or one of its fully affiliated institutions. The fellow’s supervisor must hold a full-time


faculty appointment with the University of Toronto and must also be a member of the BBDC. Stipends are normally $40,000 or $50,000 for one year. Applications are reviewed by members of the Training and Research Excellence Committee. The following are the 2013/2014 recipients:


Jacqueline Beaudry Dr. Daniel Drucker Metabolic GIPR signaling in adipose tissue and brain

Xavier Revelo Dr. Daniel Winer The Role of Neutrophil Extracellular Traps and Their Targeted Toll-like Receptors in Insulin Resistance

Ferhan Siddiqi Dr. Andrew Advani Histone methyltransferases in diabetic nephropathy

REUBEN & HELENE DENNIS SCHOLAR IN DIABETES RESEARCH (Biennial Program)

This award which was established to support new University of Toronto diabetes research faculty, provides $10,000 per year for two years. To be eligible, the applicant must be involved in diabetes research and must be a principal investigator who holds a full-time academic appointment with the University of Toronto. Faculty are eligible for this funding normally within five years of their first faculty appointment. Applications are reviewed by members of the Training and Research Excellence Committee as well as an external reviewer(s). The following is the 2012-2014 award recipient:

Recipient Title of Research Award

Dr. Andrew Advani Histone modification in diabetic nephropathy $10,000 for 2012/2013 $10,000 for 2013/2014

SUN LIFE FINANCIAL EQUIPMENT GRANTS FOR DIABETES RESEARCH

In 2009 the BBDC temporarily suspended its equipment grants program due to a lack of endowment income caused by the 2008 financial crisis. Thanks to a generous contribution from Sun Life Financial, the BBDC was able to reinstate this funding program for the 2013/2014 year. A minimum amount of $5,000 and a maximum amount of $30,000 is made available for the one-time purchase of laboratory equipment for diabetes research. To be eligible, the applicant must hold a full-time faculty appointment with the University of Toronto and must be a member of the BBDC. Applications are reviewed by members of the Training and Research Excellence Committee as well as an external reviewer(s). The 2013/2014 equipment grant recipient is:

Recipient Title of Research and Equipment Award

Dr. Andrew Advani (Principal Investigator) Dr. Kim Connelly Dr. Warren Lee Dr. Darren Yuen Dr. Richard Gilbert

Title of Research: Cell Stretch in Diabetes Equipment: Flexcell FX-5000 Tension System

$30,000

SUN LIFE FINANCIAL NEW INVESTIGATOR AWARD

Thanks to a generous contribution from Sun Life Financial, the BBDC is able to bring back this program which was also suspended in 2009 due to a lack of endowment income. This award supports new University of Toronto diabetes research faculty who are within five years of their first faculty appointment. The first Sun Life Financial New Investigator Award will be awarded for the 2014/2015 year.

SUN LIFE FINANCIAL PILOT AND FEASIBILITY GRANTS

As a result of a generous contribution from Sun Life Financial, we are delighted to report that the BBDC will once again be offering pilot and feasibility grants in the upcoming 2014/2015 year. These grants enable investigators to explore completely new initiatives in the area of biomedical research/basic science research in diabetes. The first Sun Life Financial Pilot and Feasibility Grants will be awarded for the 2014/2015 year.


TRAINEE TRAVEL AWARDS

The Trainee Travel Awards are available to U of T graduate students, undergraduate students, medical students, post-doctoral fellows, medical residents and clinical fellows conducting diabetes research. Trainees receive reimbursement of up to $1,000 (CAD) to attend a national or international meeting. To be eligible, the trainee must be presenting a first-author abstract directly related to diabetes research which has been accepted for poster or oral presentation at the meeting. The trainee’s supervisor must be a University of Toronto faculty member and a BBDC member. Applications are reviewed by members of the Training and Research Excellence Committee. The 2013/2014 award recipients are:

Period 1 Recipients (For travel occurring between July 1 and December 31, 2013):

Recipient Supervisor(s) Abstract Title

Ananya Tina Banerjee Dr. Lorraine Lipscombe Social Cognitive Theory Variables and Stages of Change for Physical Activity and Diet in South Asian versus Caucasian Women Diagnosed with Gestational Diabetes Mellitus

Kenny Chan Dr. Amira Klip Fatty acid-induced muscle-macrophage crosstalk contributes to insulin resistance

Fei Fang Dr. James Scholey Adiponectin Attenuates Angiotensin II-Induced Oxidative Stress in Renal Tubular Cells through AMPK and cAMP-Epac Signal Transduction Pathways

Sarah Farr Dr. Khosrow Adeli Glucagon-like peptide-1 regulates intestinal chylomicron production by peripheral and central signaling pathways

Kevin Foley Dr. Amira Klip Sorting into a Syntaxin-6 positive perinuclear compartment defines GLUT4 insulin sensitivity: ceramide inhibits GLUT4 sorting

Ronnie Har Dr. David Cherney Renal Hyperfiltration and Urinary Cytokines/Chemokines in Adolescents with Type 1 Diabetes Mellitus

Sayed Mohsen Hosseini Dr. Andrew Paterson Dipeptidyl peptidase 10 (DPP10) is associated with severe retinopathy in type 1 diabetes

Wilfred Ip Dr. Tianru Jin GLP-1-derived nonapeptide GLP-1(28-36)amide represses hepatic gluconeogenesis and improves pyruvate tolerance in high fat diet fed mice

Jennifer Sacco Dr. Khosrow Adeli Peripheral and central GLP-1 regulation of hepatic VLDL production in insulin resistance

Anu Shah Dr. I. George Fantus The Role of Thioredoxin Interacting Protein (TXNIP) in the Development of Diabetic Nephropathy

Period 2 Recipients (For travel occurring between January 1 and June 30, 2014)

Recipient Supervisor(s) Abstract Title(s)

Amir Bashiri Dr. Dominic Ng Cholesterol biosynthesis up-regulation plays a crucial role in HDF-induced hepatic ER stress and hepatocellular inflammasomes activation

Satya Dash Dr. Gary Lewis Glucagon like peptide 2 acutely releases stored enteral lipids as apoB-48 containing lipoproteins

Jeffrey Gagnon Dr. Patricia Brubaker Ghrelin Stimulates GLP-1 Release from the Enteroendocrine L-cell and Improves Glucose Tolerance in Mice

Shannan M. Grant Dr. Thomas Wolever The effect of continuous sipping of a glucose solution on markers of oxidation in men and women

Manuel Gil-Lozano Dr. Patricia Brubaker Effect of known disruptors of peripheral clocks, high-fat diet and constant glucocorticoid levels, on the daily rhythm of glucagon-like peptide-1 secretory responses

Alexander Ivovic Dr. Adria Giacca Oleate-Induced Beta Cell Dysfunction is Mediated Through ‘Beta-cell Insulin Resistance’


Luke W. Johnston Dr. Anthony Hanley Lower Serum Non-Esterified Eicosapentaenoic Acid (EPA) Is Associated with Insulin Resistance: PROspective Metabolism and Islet Cell Evaluation (PROMISE) Cohort

Mary LaPierre Dr. Tony Lam Hypothalamic Lipid Sensing Mechanism is Not Required for Glucagon to Regulate Glucose Production

Cynthia T. Luk Dr. Minna Woo Caspase 8 in Adipose Tissue Promotes Adipose Tissue Inflammation and Glucose Intolerance

Sudaba Mansuri Dr. Anthony Hanley Associations of Total, Bioavailable, and Free 25(OH)D concentrations with Metabolic Syndrome in an Aboriginal Canadian community

Brittany Rasmussen Dr. Tony Lam Duodenal linoleic acid sensing lowers glucose production in rats and mice via CCK-independent neuronal network

Ingrid Dominique Santaren

Dr. Anthony Hanley Pentadecanoic Acid (15:0), a Biomarker of Dairy Good Intake, is Inversely Associated with Incident Type 2 Diabetes and Its Underlying Disorders

Megan Sauve Dr. Steffen-Sebastian Bolz Augmentation of microvascular myogenic tone in a mouse model of diabetes mellitus is mediated by activation of sphingosine-1-phosphate signaling axis by tumour necrosis factor alpha

Sally Yu Shi Dr. Minna Woo Parkinson-susceptibility protein DJ-1 regulates skeletal muscle ROS and is required for diet-induced obesity and insulin resistance in mice

Ahmed Sidiqi Dr. Darren Yuen Slit2-ROBO4 Signalling as a Potential Target for Attenuating Early Diabetic Renal Hyperfiltration

Ferhan Sidiqqi Dr. Andrew Advani The histone methyltransferase EZH2 protects against podocyte oxidative stress and renal injury in diabetes

Pamuditha Silva Dr. Jon Rocheleau FGF2 signaling through Fibroblast Growth Factor receptor 5 (FGFR5) enhances beta-cell survival: potential role of Src Family Kinases

Marko Skrtic Dr. David Cherney The Intraglomerular Hemodynamic Profile of Hyperfiltration Before and After SGLT2 Inhibition in Patients with Type 1 Diabetes

Melika Zadeh Tahmasebi Dr. Tony Lam Fatty acid sensing in the ileum regulates glucose homeostasis

SURVEY OF FORMER BBDC-FUNDED TRAINEES The Banting & Best Diabetes Centre has been funding post-doctoral fellows since 1982 and graduate students since 1997. The objective of these awards is to foster young investigators and encourage careers in the field of diabetes research in both the basic sciences and clinical sciences settings. As part of our ongoing efforts to increase the effectiveness of our programs, a Web-based survey of former BBDC-funded postdoctoral fellowship and graduate studentship recipients who received their awards from 1982 to 2011 was conducted in the summer of 2014. The purpose of conducting this survey was to gain valuable insights that could help us assess the importance of our funding programs for trainees on their future studies, research, and career pathways. Of the 202 trainees who received funding from the BBDC between 1982 and 2011, we were able to find contact information for 182. The response rate was very good with 47 percent of those we contacted completing the survey. We were happy to learn that approximately two thirds of BBDC trainees who responded to the survey are still engaged in diabetes research, care, and/or education. A full report on the survey’s findings is available on the BBDC’s website at www.bbdc.org/images/pdf/Survey-Report-2014.pdf. We would like to thank BBDC Research Assistant, Ms. Luisa Garzon, for conducting the survey and preparing the report and Ms. Julie Lafford, Director of Alumni Relations, Faculty of Medicine, for her assistance. We would also like to thank Drs. Tony Lam and Daniel Drucker for their input regarding the questionnaire, as well as the BBDC trainees who took the time to respond to the survey.


EDUCATIONAL ACTIVITIES

ANNUAL SCIENTIFIC DAY

This annual event which is planned by the Training and Research Excellence Committee provides an opportunity for BBDC members to exchange scientific information and ideas, and assists in the development of collaborative diabetes-related research activities. It also provides a valuable opportunity for BBDC trainees to network and present their research. BBDC post-doctoral fellowship recipients, graduate studentship recipients and select Annual Trainee Awards abstract submitters present posters of their work. This year Dr. Randy Levinson, Senior Editor of Nature Medicine and Dr. Sreekumaran Nair, Editor-in-Chief of Diabetes co-judged ten pre-selected posters for the Annual Trainee Awards competition. The event focuses on the latest diabetes research topics with both clinical and laboratory applications. In addition, the Director has an opportunity to review the past and upcoming activities of the BBDC with the Centre membership at large. Registration is free for all BBDC members, their trainees and U of T endocrine residents. Faculty from other Universities may attend for a fee. We gratefully acknowledge partial support of this year’s event by: Amgen, AstraZeneca, Boehringer-Ingelhim/Eli Lilly Diabetes Alliance, GlaxoSmithKline, Janssen Inc., Merck Canada Inc., Novo Nordisk, Sanofi Diabetes, and the University Health Network. We are also grateful to Sun Life Financial, a major supporter of the BBDC. The program is as follows:

25th

Annual Scientific Day Friday, May 9, 2014

The Old Mill Inn, 21 Old Mill Road, Toronto

8:00 - 8:40 AM Continental breakfast and poster set-up

SESSION 1 Chair: Dr. Cristina Nostro

8:40 - 8:45 Welcome and Introduction: Dr. Tony Lam

8:45 - 9:15 Harnessing Big Data to Advance Diabetes Research Dr. Lorraine Lipscombe

9:15 - 9:45 Lipid-induced Beta Cell Dysfunction In Vivo Dr. Adria Giacca

9:45 - 10:00

Molecular Links Between Obesity and Diabetes: Adipocyte Focal Adhesion Kinase Dr. Cynthia Luk

10:00 - 11:15 Refreshments, Poster Presentations, and BBDC Annual Trainee Awards Competition poster judging by Drs. Randy Levinson and Sreekumaran Nair. Moderator: Dr. Tony Lam

SESSION 2 Chair: Dr. Richard Bazinet

11:15 - 11:45 Novel Approaches to Imaging the Atherosclerotic Plaque: Informing Drug Development Dr. Michael Farkouh

11:45 - 12:15 PM Novel Insights into the Secretion of Glucagon-like Peptide-1 Dr. Patricia Brubaker

12:15 - 12:30

BBDC Director’s Report: Dr. Gary Lewis Professor, Department of Medicine, Division of Endocrinology & Metabolism, University of Toronto

12:30 – 1:30 Lunch

1:30 - 2:30 CHARLES HOLLENBERG MEMORIAL LECTURESHIP Chair: Dr. Tony Lam The Regulation of Metabolism by Insulin Dr. Morris J. Birnbaum

2:30 - 2:40 BBDC Annual Trainee Awards Presentation 2013/2014 Drs. Randy Levinson, Sreekumaran Nair and Tony Lam

2:40 Evaluation and adjournment


GUEST SPEAKER

Morris J. Birnbaum, MD, PhD Willard and Rhoda Ware Professor of Diabetes and Metabolic Disease Perelman School of Medicine, University of Pennsylvania

LOCAL SPEAKERS *University of Toronto

Patricia Brubaker, PhD Professor and Canada Research Chair, Departments of Physiology and Medicine* Staff Scientist, Division of Endocrinology & Metabolism* Michael Farkouh, MD, PRCPC, FACC, FAHA Peter Munk Chair in Multinational Clinical Trials, Peter Munk Cardiac Centre Director, Heart and Stroke Richard Lewar Centre of Excellence in Cardiovascular Research Associate Professor, Department of Medicine* Adria Giacca, MD Professor, Department of Physiology; Department of Medicine*

Lorraine Lipscombe, MD, MSc, FRCPC Clinician Scientist, Women’s College Hospital Adjunct Scientist, Institute for Clinical Evaluative Sciences Assistant Professor, Department of Medicine; Department of Health Policy, Management and Evaluation* Cynthia Luk, PhD Research Fellow, Endocrinology and Metabolism, University Health Network 2013/2014 BBDC Postdoctoral Fellowship Recipient (Supervisor: Dr. Minna Woo) POSTER JUDGES

Randy Levinson, PhD Senior Editor, Nature Medicine Sreekumaran Nair , MD, PhD Professor of Medicine, Mayo Clinic and Foundation Editor-in-Chief, Diabetes

Drs. Sreekumaran Nair (left) and Randy Levinson (centre) judge a poster at the Scientific Day.

Scientific Day guest speaker Dr. Morris Birnbaum.


BBDC SEMINAR SERIES (at City-wide Endocrine Rounds)

Each year the BBDC invites guest lecturers to present their work on diabetes research at our Seminar Series. To ensure a broad audience, seminars have been incorporated into the University of Toronto City-wide Endocrine Rounds which are held every Friday morning at the Mount Sinai Hospital. This year’s presentations are as follows:

BBDC Seminar Series 2013/2014 In conjunction with City-wide Endocrine Rounds

8:00 – 9:00 a.m. Mount Sinai Hospital, Lebovic Building

60 Murray Street, 3rd

Floor Conference Room

November 15, 2013 Learning from the histopathology of type 1 diabetes to devise better immunotherapeutic strategies Matthias von Herrath, MD Professor, La Jolla Institute Vice President and Head, Novo Nordisk R & D Center Seattle

December 6, 2013 Hypothalamic dysfunctions and metabolic syndrome Dongsheng Cai, MD, PhD Professor, Department of Molecular Pharmacology, Albert Einstein College of Medicine

February 28, 2014 Significance of islet cell regeneration in type 1 diabetes Rohit N. Kulkarni, MD, PhD Associate Professor of Medicine, Harvard Medical School Senior Investigator, Islet Cell Biology & Regenerative Medicine, Joslin Diabetes Center

April 4, 2014 Novel Functions of HDL and their Relationship to Athero-thrombosis Alan Tall, MD Tilden Weger Bieler Professor of Medicine, Columbia University

CHARLES HOLLENBERG SUMMER STUDENTSHIP PROGRAM: WEEKLY SEMINAR SERIES AND MINI-CONFERENCE 2014

Summer studentship recipients and their supervisors are required to participate in the Charles Hollenberg Summer Studentship Program which consists of a weekly Seminar Series and a half-day Mini-conference. The weekly seminars are held every Tuesday from 4 to 5 p.m. throughout June and July. Each seminar includes two 20-minute presentations prepared by two supervisors, followed by two 5-minute presentations by their summer students describing how their projects fit into the overall goals of their labs. All students present the results of their work at the end of the summer in a workshop format at the half-day Mini-conference. The BBDC would like to thank Dr. Jonathan Rocheleau for coordinating the 2014 Summer Studentship Program. The 2014 Mini-Conference program is as follows:

2014 Charles Hollenberg Summer Student Mini-Conference Tuesday, August 5, 2014

12:45 - 4:30 p.m. Toronto Medical Discovery Tower

101 College Street, 4th

Floor Seminar Room 4-204

12:45 PM Students to load presentations onto computer in seminar room.

12:55 Introduction: Dr. Jonathan Rocheleau, Program Coordinator

1:00 Rebecca Wang (Dr. Catherine Yu) Assessing the Impact of Animated Comics on Diabetes on Senior Medical Students’ Approach to Patient Interactions


1:15 David Han (Dr. Denise Belsham) The Effect of Excess Nutrients on the Hypothalamic Neurons

1:30 Giuliana Guarna (Dr. Andrew Advani) JAK2 in Diabetic Nephropathy

1:45 Catherine Lu (Dr. James W. Scholey) Investigating the role of Adiponectin on the TGF-β pathway in Human Mesangial Cells

2:00 Emily McGaugh (Dr. M. Cristina Nostro) The Role of EGF Signaling During Pancreatic Development

2:15 Serena Wang (Dr. Michael Wheeler) Discovery of Novel Targets of Insulin Secretion in Pancreatic Beta Cells

2:30 Lauren Chan (Dr. Darren Yuen) Slit2-Robo Signaling: A Novel Regulator of Early Pathological Angiogenesis in Diabetes

2:45 Refreshment break

3:00 Paola Hunter (Dr. Patricia Brubaker) Circadian Regulation of Glucagon-like Peptide-1 Secretion from Human L-cells

3:15 Darshan Sivaloganathan (Dr. Amira Klip) Palmitoleate Prevents Palmitate-induced Pro-inflammatory Macrophage Polarization

3:30 Parmveer Singh (Dr. David Irwin) The Effect of Hepatic Glucokinase Deficiency on Genes Encoding ChREBP and MondoA

3:45 Alyssa Molinaro (Dr. Derek van der Kooy) The Influence of the Local Tissue Environment on Fate Determination of Mouse Pancreatic Stem Cells

4:00 Jacalyn Kelly (Dr. Khosrow Adeli) Closing the Gaps in Pediatric Reference Intervals: The CALIPER Initiative - Next Steps

4:15 Richard Yang (Dr. Qinghua Wang) GABA Attenuates High-Fat Diet induced Insulin Resistance and Glucose Intolerance by Suppressing TNF-α Secretion in the Liver

DIABETES UPDATE

Diabetes Update is a biennial continuing education event which is planned by the BBDC’s Continuing Health Education and Professional Development Committee. This one-day event attracts over 500 health care providers in primary and specialty care who are involved in diabetes education and management such as, but not limited to, physicians, nurses, dietitians and pharmacists from across Ontario. The program includes guest and local speakers and is comprised of plenary lectures and smaller interactive breakout sessions. The next Diabetes Update will be held on Friday, March 6, 2015 at the Metro Toronto Convention Centre.

U OF T/BBDC DIABETES AND ENDOCRINOLOGY UPDATE FOR PRIMARY CARE PRACTITIONERS

This full-day continuing education event is organized by Dr. Rene Wong, Chair of the BBDC’s Continuing Health Education and Professional Development program and is co-hosted by the University of Toronto Division of Endocrinology and Metabolism and the Banting & Best Diabetes Centre. The event is targeted to health care providers in primary care and enrollment is normally limited to 100 participants in order to maximize learning potential. The most recent Diabetes and Endocrinology Update was held on Friday, April 4, 2014. The program as well as past programs can be found at www.cpd.utoronto.ca/diabetesendocrinology.

http://www.cpd.utoronto.ca/diabetesendocrinology


CORE LABORATORY The BBDC Core Laboratory provides high quality laboratory services to diabetes researchers at the University of Toronto involved in clinical and/or basic research. The lab also provides services to the wider scientific community including external academic and/or industry initiated research. The BBDC is expanding its Core Laboratory services to better serve the needs of BBDC researchers and affiliates as the BBDC expands its research enterprise. A steering committee of BBDC members based at Mount Sinai Hospital, The Hospital for Sick Children, and St. Michael’s Hospital have established close collaborations across institutions in order to offer a more complete lab inventory that will greatly support diabetes researchers. A list of current services and assays provided by the Core Lab is available on the BBDC’s web site at www.bbdc.org or by contacting the Core Lab directly:

Director: Dr. George Fantus Phone: (416) 586-8665 E-mail: [email protected]

Co-Director: Dr. Azar Azad Phone: (416) 586-8545 E-mail: [email protected] Address: Mount Sinai Hospital, 600 University Avenue, 6th Floor, Room 600, Toronto, Ontario M5G 1X5

COMMUNICATIONS

WEBSITE: BBDC.ORG

Visitors to our site can view detailed information on all of the BBDC’s discovery and applied research programs, funding programs and funding decisions, educational activities, current diabetes research activities being conducted by our members, links to local and international diabetes meetings, and much more.

E-MAIL LIST

Our members and others who join our e-mail list receive notifications regarding BBDC funding programs, seminars, educational events, the BBDC newsletter and other notifications which may be of interest to the University of Toronto diabetes research, care or education communities.

NEWSLETTERS

BBDC NEWS is distributed by e-mail to our members and those who have joined our e-mail list. Issues are distributed three times per year in the fall (September), winter (January), and spring (June) to over 425 diabetes researchers, health professionals, fellows and students, most of whom are affiliated with the University of Toronto. The newsletter highlights upcoming BBDC events, funding opportunities, award results, seminars and more. Current and past issues are available on the BBDC’s web site. BBDC PHARMACY NEWSLETTER was launched in November 2013 to pharmacists across Canada. The newsletter is a new initiative to update pharmacists and other stakeholders on the latest pharmacy-related knowledge translation and optimizing care efforts ongoing in the Banting & Best Diabetes Centre. Current and past issues are available on the BBDC’s web site.

SOCIAL MEDIA

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ACKNOWLEDGEMENTS We would like to express our sincerest gratitude and appreciation to the following:

The members of our Training and Research Excellence Committee and our Continuing Health Education & Professional Development Committee who volunteer their time to review applications for the Centre’s funding programs and to organize educational events on behalf of the BBDC.

The members of our Executive Committee, Discovery Research Steering Committee, and Applied Research Steering Committee.

Dr. Jonathan Rocheleau for coordinating the 2014 Charles Hollenberg Summer Studentship Program.

Drs. Patricia Brubaker, Mike Domanski, George Fantus, Hertzel Gerstein, Adria Giacca, Peter Liu, Remi Rabasa-L’Horet, Allen Volchuk, and Minna Woo for providing scientific reviews for various BBDC funding programs this past year.

Everyone who participated in our 25

th Annual

Scientific Day including speakers Drs. Morris Birnbaum, Patricia Brubaker, Michael Farkouh, Adria Giacca, Lorraine Lipscombe and Cynthia Luk, and the 2013/2014 Annual Trainee Awards poster judges, Drs. Randy Levinson and Sreekumaran Nair.

Our fundraisers: Shauna Seabrook (Toronto General & Western Hospital Foundation), and Raissa Espiritu (University of Toronto Advancement)

BBDC Research Assistant, Luisa Garzon, who conducted the survey of former BBDC-funded postdoctoral fellows and graduate students; Julie Lafford, Director of Alumni Relations, Faculty of Medicine, for her assistance; and Drs. Tony Lam and Daniel Drucker for their input regarding the survey questionnaire.

OUR SUPPORTERS The Banting & Best Diabetes Centre gratefully acknowledges endowed financial support from the following contributors:

C. H. Best Memorial Fund The Estate of Reuben & Helene Dennis The Estate of Marion Hamilton The Estate of Miriam Neveren The Estate of Dr. & Mrs. Edward A. Sellers The Estate of Mary E. Sharp The Estate of Archie Sopman (Toronto General & Western Hospital Foundation) The Estate of Arthur Spoerri Novo Nordisk Mr. Stephen Yow Mok Shing The Centre is also grateful to the following for contributions made between July 2013 and June 2014:

Amgen AstraZeneca Boehringer-Ingelhim/Eli Lilly Diabetes Alliance Eli Lilly Canada The Estate of Astrid L. Taim Faculty of Medicine, University of Toronto GlaxoSmithKline Heart & Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research Janssen Inc. Merck Canada Inc. Novo Nordisk Sanofi Diabetes Sun Life Financial Takeda Canada Toronto General & Western Hospital Foundation University Health Network Individuals who have donated to the Banting & Best Diabetes Centre this past year. The BBDC gratefully acknowledges the support of our major contributors:

200 Elizabeth Street, Eaton Building, 12E248, Toronto, Ontario, Canada M5G 2C4 Phone: (416) 978-4656 ⦁ [email protected] ⦁ www.bbdc.org

annual report july 2013 - june 2014 · 2018-02-02 · medicine & pathobiology* dr. alison...

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