annual report 2009 - quteprints.qut.edu.au/32954/1/merf_annual_report_2009_for_publication.pdf ·...

ANNUAL REPORT 2009

For Period 1st

January to 31st

December 2009

Institute of Health and Biomedical Innovation

Faculty of Built Environment and Engineering

Our Mission:

“Make a positive difference to people’s lives by

improving health care through clinically relevant research and

training.”

[2]

MERF ANNUAL REPORT 2009

(Front Cover – Front View of Medical Engineering Research Facility)

[3]


TABLE OF CONTENTS

Page Nos

DIRECTOR’S OVERVIEW ………………………………………………………………………………………...

INTRODUCTION TO MERF …………………………………………………………………………………..…

1.HIGHLIGHTS, BREAKTHROUGHS, DIFFICULTIES.…………………………………..……………

1.1 Report on MERF Anatomical and Surgical Skills Laboratory (ASSL)

1.2 List of ASSL Workshops for 2009

1.3 Report on the MERF Biological Research Facility (BRF)

1.4 BRF Animal Workshops in 2009

1.5 Report on Research Labs (RL)

2. RESEARCH…………………………………………………………………………………………………………..

2.1 Activities in Research Laboratories

2.1.1 Projects Conducted in 2009

2.1.2 Projects Planned for 2010

3. EDUCATION AND TRAINING ……………………………………………………………………………..

3.1 Scholarships in 2009

4. PERSONNEL………………………………………………………………………………………………………..

4.1 Staffing at MERF

4.2 Researchers Utilising MERF

4.3 Research Students Utilising MERF Facilities

5. NON-GOVERNMENT RESEARCH GRANTS FOR 2009

6. COMMERCIALISATION……………………………………………………………………………………….

Attachment 1 – Publications…………………………………………………………………………………

Attachment 2 - Media Release – QUT Bluebox……………………………………………………

Attachment 3– Australian Government Research Grants 2009………………………….

4

5

6

6

7

7

8

9

10

11

11

12

13

13

14

15

15

15

16

18

19

23

24

[4]


DIRECTOR’S OVERVIEW by Professor Mark Pearcy

However, we have learnt that there is much more that can be achieved and the emphasis will be on

working with the university, government and external partners to realise the full potential of MERF

by further development of the Facility.

In 2009 we conducted 28 workshops in the Anatomical and Surgical Skills Laboratory providing

training for surgeons in the latest techniques. This was an excellent achievement for the first full

year as our reputation for delivering first class facilities and support grows. The highlight, perhaps,

was a course run via our video link by a surgeon in the USA directing the participants in MERF. In

addition, we have continued to run a small number of workshops in the operating theatre and this

promises to be an avenue that will be of growing interest. Final approval was granted for the QUT

Body Bequest Program late in 2009 following the granting of an Anatomical Accepting Licence. This

will enable us to expand our capabilities by provide better material for the workshops. The QUT

Body Bequest Program will be launched early in 2010.

The Biological Research Facility (BRF) conducted over 270 procedures in 2009. This is a wonderful

achievement considering less then 40 were performed in 2008. The staff of the BRF worked very

hard to improve the state of the old animal house and this resulted in approval for expanded use by

the ethics committees of both QUT and the University of Queensland.

An external agency conducted an Occupational Health and Safety Audit of MERF in 2009. While

there were a number of small issues that require attention, the auditor congratulated the staff of

MERF on achieving a good result, particularly for such an early stage in the development of MERF.

The journey from commissioning of MERF in 2008 to the full implementation of its activities in 2009

has demonstrated the potential of this facility and 2010 will be an exciting year as its activities are

recognised and further expanded building development is pursued.

Professor Mark Pearcy PhD, DEng, FIEAust, CPEng(Biomed)

Director of MERF

Professor of Biomedical Engineering

Institute of Health and Biomedical Innovation and

Faculty of Built Environment and Engineering

This report for 2009 is the first full year report

for MERF. The development of our activities in

2009 has been remarkable and is testament to

the commitment of the staff to the vision of

MERF as a premier training and research

facility. From the beginnings in 2003, when a

need was identified for the provision of

specialist research and training facilities to

enable close collaboration between

researchers and clinicians, to the realisation of

the vision in 2009 has been an amazing

journey.

[5]


Introduction to Medical Engineering Research Facility (MERF)

MERF Foyer and Breakout Area

The Queensland Government Smart State Facilities Fund awarded $5,000,000 to QUT in June 2004

to establish the Medical Engineering Research Facility (MERF) at The Prince Charles Hospital,

Chermside. QUT provided funding of $4.15 million to complete the construction and fit out, with

funding and equipment support from industry partners, Medtronic and Stryker. The Prince Charles

Hospital is supporting this $10.7 million facility by providing land as well as equipment and staff

support.

MERF is designed to meet Australia’s emerging needs in orthopaedic and artificial organs research.

It provides a comprehensive suite of research and training facilities at the one location, including:

� Research aimed at solving problems identified by clinicians in their practice, and directed or

co-directed by the clinicians;

� Research into new techniques, materials, devices, procedures, and manufacturing

techniques for medical devices; and

� Training of clinicians and other professional health workers in new products and techniques.

[6]


1. Highlights, Breakthroughs and Difficulties

1.1 Report on MERF Anatomical and Surgical Skills Laboratory (ASSL)

Highlights – MERF has been operating for eighteen months, with 2009 being the first entire year of

operation. This year has seen the successful completion of 28 surgical training workshops for a total

income of $311,629. These workshops were related to areas ranging from the ankle to the head

with many others in between. The most prevalent type of workshop is spinal (6) followed by hips

(5), with knee (4) and gynaecology (4) equal third.

Breakthroughs – The QUT Body Bequest Program will be underway in early 2010. It has taken much

longer than expected to produce and have authorised the necessary paperwork to be utilised in this

Program.

Difficulties - A total of 16 workshops were cancelled during 2009 representing the loss of

approximately $250,000 of potential income. The main reasons for these workshops not proceeding

were a combination of the economic down turn we had mid-year, coupled with the swine flu scare

that saw many surgeons and prospective delegates refuse to fly. Other reasons for cancellations

were related to fresh/frozen cadaveric material requirement and the need to have more than 6

workstations for the workshops to proceed. The QUT Body Bequest Program starting in early 2010

should alleviate some of the issues with the availability of fresh rather than embalmed cadaveric

material for workshops.

Photos from Synthes Spinal

Training Workshop held on 6 -7

November 2009

[7]


1.2 List of ASSL Workshops for 2009

Workshop Dates in 2009 Client & Workshop

9th

January Stryker Hip

30th

- 31st

January Stryker Knee

30th

January Stryker Ankle/Foot

20th

Februry Brisbane Rehab

6th

March Surgilink Gyn

9th

March PA Trauma

20th

March Postlaryngectomy

31st

March Gyno Oncology

4th

April Depuy Spine

16th

- 17th

May Medtronic Spinal

20th

May Medtronic Auto Transfusion

6th

July Smith & Nephew Hip Trail

11th

July Surgilink Gyn Workshop

2nd

August AMS Gyn

8th

August Smith & Nephew Hip

26th

August Smith & Nephew Knee

8th

September Cook Medical Gyn

. 9th

September Smith & Nephew Knee

17th

October Medacta Hip

26th

– 28th

October Stryker Navigation

6th

– 7th

November Synthes Spine

13th

November AMS Gyn

21st

November Surgilink & AM Gyn

24th

Novmeber Zimmer Spine

27th

November Smith & Nephew Hip

28th

November Depuy Spine

5th

December Medtronic Spine

15th

December Smith & Nephew Knee

1.3 Report on the MERF Biological Research Facility (BRF)

Highlights - The BRF had a very productive year with some 270 successfully completed procedures,

which is an increase of some 800% from the previous year. This gave us a positive income of around

$100,000 + for the year, with further income of around $70,000 from 2009 which will not be realised

until the 2010 period.

Breakthroughs - We have engaged an off-site facility at Mt Cotton to agist our sheep. With our best

practice maintenance undertaken during the Christmas break, and a decrease in animals in the

paddocks due to our Mt Cotton facility, we are able to keep paddocks at MERF in a much better

condition over a longer period. The staff are continuing to refine policies and procedures at both

MERF and at our Mt Cotton facility and are enthusiastic about undertaking training which will

further enhance our capabilities in the years to come.

Further refurbishment of the animal house was undertaken in 2009. QUT spent $80,000 on a new air

conditioning system and the BRF staff refurbished the interior. This resulted in the ethics

committees of both QUT and the University of Queensland approving the facility for continuing use.

[8]


Dr Kathleen Wilson (Vet) retired in October 2009 but has been engaged on a consultancy basis to

work at MERF part-time. She brings a wealth of knowledge and experience which can only enhance

MERF’s capabilities. In the latter part of 2009 following Dr Wilson’s retirement, Michael Lindeberg

was installed as the Manager of the BRF area.

We have three other Vets who work on either a full-time or part-time basis. They organise the

workshops, assist researchers with their Animal Ethics Applications and in writing up the Standard

Operating Procedures (SOP) which are necessary to run this facility.

Difficulties – The difficulties we face for the future relate to obtaining additional sponsorship to

purchase much needed equipment which will allow us to further our research and external

workshops in the future.

1.4 BRF Animal Workshops in 2009

Workshop Dates in 2009 Client & Workshop

4th

& 6th

February Johnson and Johnson Fibrin Patch

10th

March PA Animal Trauma

18th

August Wal Grimmett – Pilot Study

MERF animal yards where stock

are kept

BRF Operating Theatre set up prior

to an operation

[9]


1.5 Report on Research Laboratories

The Research Laboratories have been used by researchers studying issues ranging from how

temperature affects the strength of plaster casts for treating fractures to how hyperbaric treatment

affects recovery from spinal cord injury.

Highlights – The Research Laboratories have had growing utilisation in 2009 as researchers from IHBI

and TPCH have identified the unique character of MERF.

Breakthroughs – The undertaking of joint replacement research at MERF demonstrating the value of

having cadaveric material available in the same building as laboratories for mechanical

characterisation of implanted devices.

Difficulties – The difficulties we face for the future are providing sufficient space for researchers to

base themselves at MERF whilst undertaking research projects using the MERF facilities.

Instron Machine – Testing the torsional

stability of a hip joint

[10]


2. Research

Research being undertaken at MERF:

• Design of replacement joints;

• Bone replacement and cartilage replacement systems;

• Biology of spinal injury and reduction of resulting disability;

• Promotion of bone healing;

• Optimising spinal surgical procedures;

• Augmentation for osteoporotic bone and crush fractures;

• Non-biological replacement organs (e.g. artificial heart);

• Smoke inhalation and treatment to reduce morbidity;

• Effect of brain death on organs for transplantation.

Some of the clinical conditions positively affected by the work are:

• Joint (hip and knee) replacements due to arthritis, injury, osteoporosis and other causes;

• Fracture treatment for long-bones and fractured neck or femur (including as a result of

trauma);

• Cancer requiring bone tumour resection surgery;

• Spinal deformity, back pain (includes disc regeneration), and osteoporotic spines;

• Spinal cord trauma and cord injury;

• Congestive heart failure and impaired functioning of other organs;

• Organ transplantation.

MERF research facilities include operating theatres, cell culture laboratories, materials testing

laboratories and mechanical and electrical workshops.

[11]


2.1 Activities in Research Laboratories

2.1.1 Projects Conducted in 2009

Researcher Affiliations of

Investigators and

Other Facilities Utilised

Project Status

Mrs Monica

Beldiman

QUT/IHBI Cartilage mechanics Ongoing

2009

Mr Greg Couzens QUT/IHBI Scaphoid / Lunate wrist fracture fixation

methods

Ongoing

2009

Mr Kimble Dunster QUT/TPCH Does setting temperatures effect the

strength of plaster of Paris casts

Completed

2009

Mr Kimble Dunster QUT/TPCH Single lung lavage model in the rat Ongoing

2009

Professor John

Fraser

TPCH Lung transplant procedures Ongoing

2009

Mr Thor Friis QUT/IHBI Cell culture research for arthritis and bone

replacement

Ongoing

2009

Dr Ben Goss QUT/IHBI Pilot study to establish a contusion spinal

cord injury model

Ongoing

2009

Dr Ben Goss QUT/IHBI Assessment of a biomaterial for bone

replacement

Ongoing

2009

Dr Ben Goss QUT/IHBI Delivery of neurotrophic factors as an

adjunct therapy to the growth factor

mediated resolution of post spinal cord

injury inflammation

Ongoing

2009

Dr Laura Gregory QUT/IHBI Investigating the relationship between

bone marrow composition and bone tissue

quality

Ongoing

2009

Ms Daisy Irawan QUT/IHBI Bovine chondrocyte isolation Onging

2009

Mr Ali Kalhor

Moghaddan

QUT/TPCH Design and fabrication of an engineered

bone graft system (EBGS) by combining a

composite scaffold and growth factor

delivery system

Ongoing

2009

Dr Siamak

Saifzadeh

QUT/IHBI Tissue engineering as a potential approach

for the treatment of osteonecrosis

Ongoing

2009

Dr Sanjleena Singh QUT/IHBI Cellular biology of cartilage

Dr Roland Steck QUT/IHBI Plastic bone testing Ongoing

2009

Ms Tanja

Windegger

UQ/TPCH Effect of brain death to immunogenicity of

transplanted lungs

Ongoin

2009

Dr Lance Wilson QUT/IHBI Femoral fracture investigations Ongoing

2009

[12]


2.1.2 Projects Planned for 2010

Researcher Affiliations of

Investigators and

Other Facilities Utilised

Project Status

Mrs Indira

Prasadam

QUT/IHBI The potential appliation of mitogen

activated protein kinase (MAPK) signalling

pathway modulators for the treatment of

osetoarthritis

Starting

2010

Dr Siamak

Saifzadeh

QUT/IHBI Evaluation of novel surface modified

scaffolds in a rat calvarial model

Starting

2010

[13]


3. Education and Training

3.1 Scholarships in 2009

Below is a list of Higher Degree Research Scholarships recipients which relate to both IHBI and

MERF:-

PhD

Isaac Afara

Monica Beldiman

Nicola Cairns

Wei Fan

Helen Fairhurst

Thor Friis

Nick Gaddum

Caroline Grant

Nick Greatrex

Shaun Gregory

Hazreen Harith

Daisy Irawan

June Jeon

Navdeep Kaur

PhD’s cont…

Sridevi Surapaneni

Victoria Toal

Martin Wullschleger

Will Young

Kenny Yusuf

Yinghong Zhou

Masters

Arne Berner

Greg Couzens

Imran Sattar

Mark Shillington

Chris Thomas

Pushpanjali Krishnakanth

Kunnika Kuaha

Gang Liu

Katrina Mc Donald

Hayley Moody

Indira Prasadam

Kanchana Rathnayaka

Johannes Reichert

Verena Reichert

Rachel Shiu

Shirly Sieh

Sanjleena Singh

[14]


4. Personnel

In September 2009 our Operations Manger, Mr Keith Officer, returned to his role in HR and QUT

employed Mr Mark Goulston to take over this position. He brings a wealth of knowledge in the area

of management and business development.

Dr Kathleen Wilson retired at the end of November 2009 and is now working for MERF in a

consultative capacity.

Medical Engineering Research

Facility (MERF)

Directorate:

Professor Mark Pearcy

Professor Ross Crawford

Dr Philip Lee

MERF Operations Manager

Mark Goulston (HEW10)

Administration

Coordinator

Gail Stringfellow (HEW5)

ASSL Manager

James Kelly (HEW8)

ASSL Assistant

Ian Mellor

(HEW5)

BRF Manager (TPCH)

Michael Lindeberg

(1.0 FTE)

Katrina Whitting

Veterinarian (0.4 FTE)

Siamak Saifzadeh Veterinary

Scientist (0.6 FTE)

BRF Attendant (TPCH)

Bill Sommers (1.0 FTE)

BRF Attendant (TPCH) Peter

Lindeberg (0.0 FTE)

Supervising Technician

Greg Tevelen (HEW7)

Technical Officer

David McIntosh (HEW5)

Anatomical

Surgical Skills

Laboratory

(ASSL)

MERF

Administration

Biological

Research

Facility (BRF)

Research

Laboratories

& Technical

Support

ASSL Assistant

(Part Time)

Duncan Norris

(HEW4)

Kathleen Wilson

Veterinary Consultant

(0.1 FTE)

[15]


4.1 Staffing at MERF

Directorate

Professor Mark Pearcy - QUT

Professor Ross Crawford - QUT

Dr Philip Lee – TPCH

Operations

Mr Mark Goulston (QUT)

Mrs Gail Stringfellow (QUT)

Anatomical Surgical Skills Laboratory

Mr James Kelly - QUT

Mr Ian Mellor – QUT

Mr Duncan Norris (Part-Time) – QUT

Biological Research Facility

Dr Katrina Whitting (Part Time) – QUT

Mr Michael Lindeberg – TPCH

Mr Peter Lindeberg – TPCH

Dr Siamak Saifzadeh (part-time) - QUT

Mr William Sommers – TPCH

Dr Kathleen Wilson (full-time) – TPCH

Research Laboratories and Technical Support

Mr Greg Tevelen - QUT

Mr David McIntosh – QUT

4.2 Researchers Utilising MERF Facilities

QUT/IHBI

Dr Ben Goss

Dr Beat Schmutz

Dr Kris Roy

Professor Ross Crawford

Dr Johannes Reichert

Professor Michael Schuetz

Dr Laura Gregory

Professor Dietmar Hutmacher

Dr Devakara Epari

Dr Lance Wilson

Professor Kunle Oloyede

Mr Roland Steck

QUT/TPCH

Mr Kimble Dunster

TPCH

Professor John Fraser

Professor Andreas Schibler

Mr John-Paul Tung

UQ

Associate Professor Lindsay Brown

Dr Tanja Windegger

4.3 QUT Research Students Utilising MERF

Facilities Isaac Afara

Monica Beldiman

Arne Berner

Nicola Cairns

Greg Couzens

Wei Fan

Thor Friis

Nick Gaddum

Caroline Grant

Nicholas Greatrex

Shaun Gregory

Daisy Irawan

Navdeep Kaur

Pushpanjali Krishnakanth

Katrina McDonald

Ali Kalhor Moghaddan

Hayley Moody

Indira Prasadam

Mark Shillington

Siamak Saifzadeh

Mark Shillington

Rachel Shiu

Sanjlenna Singh

Victoria Toal

Tanja Windegger

Martin Wullschleger

Yun Wai Young (Will)

Kenny Yusuf

Yinghong Zhou

[16]


5. NON-GOVERNMENT RESEARCH GRANTS FOR 2009

Project Title Chief Investigator Grantor

Development and Characterisation of an Osteoinductive Polymeric Bone Graft Substitute Material for use in Orthopaedic Surgery Dr Ben Goss Queensland Government

Development and Characterisation of an Osteoinductive Polymeric Bone Graft Substitute Material for use in Orthopaedic Surgery Dr Ben Goss Synthes Australia Pty Ltd

Development of a Prothrombogenic Bone Graft Substitute Prof Ross Crawford Australian Research Council (ARC)

Development and Optimization of Lipid Surfactant-Based Potential Formulas for the Prevention and Treatment of Osteoarthritis Prof Kunle Oloyede Stryker Pty Ltd

Developing Tissue Engineered Product for Clinical Application Using a Model of Temporomandibular Joint Disorders A/Prof Yin Xiao Department of Innovation, Industry, Science and

Research (Commonwealth)

Novel Sythnthetic Biomimic Polymers for Mesenchymal Stem Cell Delivery A/Prof Yin Xiao Prince Charles Hospital

Application of a Human Bone Engineering Platform to an In Vivo Prostate Cancer Model Prof Dietmar Hutmacher Prostate Cancer Foundation of Australia

Understanding the Biomechanical Effects of Fixation Strategies to Improve the Technology of Fracture Management

Prof Michael Schuetz Synthes Australia Pty Ltd

Scientific Study of Characteristics and Performance of Bone Morphogenic Proteins Dr Ben Goss Queensland Orthopaedic Research Trust

Tissue Engineering Bone - Reconstruction of Critical Sized Segmental Bone Defects in Large Animal Model

Prof Dietmar Hutmacher The Wesley Research Institute LTD

Effects of hyperbaric oxygen and aminoguanidine treatment on femoral head osteonercrosis in a rat model A/Prof Yin Xiao Queensland Orthopaedic Research Trust

Chair in Orthopaedic Research Prof Ross Crawford Queensland Government

Donation Towards Salary, Miscellaneous, Travel and Equipment Prof Ross Crawford Stryker Pty Ltd

[17]


5. NON-GOVERNMENT RESEARCH GRANTS FOR 2009 (cont.)

Project Title Chief Investigator Grantor

Sponsorship of the Project "A Prospective, Randomised, Single-blind, Multi-centre Clinical Study to Evaluate the Comparative Effectiveness of the Scorpio and Mobile Bearing Knee Prof Ross Crawford Stryker Pty Ltd

Collaborative Research Agreement -Stryker, Lance Wilson Prof Ross Crawford Stryker Australia Pty Ltd

Spine Research Program Prof Mark Pearcy Queensland Orthopaedic Research Trust

Stryker Navigation Fellow (Kamal Deep) Prof Ross Crawford Stryker Pty Ltd

Chair in Traumatology Prof Michael Schuetz Princess Alexandra Hospital

CT Database for Fracture Modeling Prof Michael Schuetz Synthes Asia & Pacific

The Northside (HSN) Spine Research Group Prof Mark Pearcy Queensland Orthopaedic Research Trust

OCS MERF - STRYKER Professional Development courses Prof Mark Pearcy Stryker Pty Ltd

OCS MERF - Medtronic Inc (IHBI) Prof Mark Pearcy Medtronic Australasia Pty Ltd

OCS MERF - Princess Alexandra Hospital Trauma Service (IHBI) Prof Mark Pearcy Princess Alexandra Hospital

[18]


6. Commercialisation

In 2009 MERF researchers worked through IHBI and QUT’s technology transfer and commercia-

lisation company, qutbluebox (bluebox) to review potential IP and commercialisation opportunities.

Two patent applications relating to activities in MERF were filed by bluebox during 2009.

Year Filed Technology Phase Country Priority

Number

2009

Methods of Treatments of

Osteoarticular Disease

Provisional

United States

US61/255259

2009

Safety Device

Provisional

Australia

2009904042

MERF researchers continue to work closely with bluebox staff, and aim to identify additional new

opportunities in 2010.

[19]


Attachment 1 - Publications

MERF has only been operational since the middle of 2008 and yet it has already provided

facilities to assist researchers and PhD students to complete studies that are now being

published in international literature.

Conference Presentations

Fairhurst , Helen and Littl, J. Paige and Adam, Clayton J. (2009) The measurement of applied

forces during anterior single rod correction of adolescent idiopathic scoliosis. In: Adelaide

Centre for Spinal Research (ACSR) - Spinal Research Symposium VII , 25-27 August, Barossa

Valley, Adelaide, Australia.

Ibrahim, Salma and Chen, Gongfa and Schmutz, Beat and Mishra, Sanjay K. and Schuetz,

Michael (2009) A novel approach to determine screw configurations in internal fixation using

an optimisiation algorithm. In: Australian and New Zealand Orthopaedic Research Society

15th Annual Scientific Meeting, 8-10 October, 2009, Adelaide, Australia.

Little, J. Paige and Adam, Clayton J. (2009) Computer simulation in spine biomechanics : An

application in adolescent idiopathic scoliosis. In: Adelaide Centre for Spinal Research (ACSR)

- Spinal Research Symposium VII , 25-27 August, Barossa Valley, Adelaide, Australia.

Tung JP, Fung YL, Nataatmadja M, Colebourne K, McMurray P, Mohammed H, Wilson K,

Wood P, Silliman C, Fraser J.(2009) Preliminary Findings from an Ovine Model of Blood

Component Therapy Developed to Investigate Transfusion-Related Acute Lung Injury. In:

HAA Annual Scientific Meeting, Adelaide. (Presidential Symposium Prize).

Young, Yun Wai and Lutton, Cameron J. and Meedeniya, Adrian C. B and Mackay-Sim, Alan

and Goss, Benjamin G. (2009) Reduction of Secondary Degeneration after Spinal Cord Injury

by Acute Delivery of Proinflammatory Growth Factors. In: Society for Neuroscience 2009, 17-

21, 2009, Chicago, IL . USA.

Conference Papers

Frossard, Laurent A. and Tranberg, Roy and Haggstrom, Eva and Pearcy, Mark J. and

Brånemark, Rickard (2009) Fall of a transfemoral amputee fitted with osseointegrated

fixation : loading impact on residuum. In: 18th Annual General Meeting of European Society

of Movement Analysis in Adults and Children , 14-19 September 2009, Savoy Place, London.

Grant, Caroline A. and Schmutz, Beat and Steck, Roland and Schuetz, Michael and Epari,

Devakara R. (2009) Creation of a validated 3D finite-element model of an ovine tibia. In: 4th

Asia Pacific Biomechanics Conference, 14-17 April 2009, University of Canterbury,

Christchurch.

[20]


Attachment 1 – Publications - Conference Papers Continued…

McDonald, Katrina A. and Little, J. Paige and Pearcy, Mark J. and Adam, Clayton J. (2009)

Relative roles of cortical and trabecular thinning in reducing osteoporotic vertebral body

stiffness: A modeling study. In: 13th International Conference on Biomedical Engineering

(ICBME), 3-6 December, 2008, Singapore.

Rathnayaka, Kanchana and Sahama, Tony R. and Schuetz, Michael and Schmutz, Beat (2009)

Validation of 3D models of the outer and inner surfaces of an ovine femur. In: 15th Annual

Scientific Meeting of Australia and New Zealand Orthopaedic Research Society, 8-10

October 2009, University of Adelaide, Adelaide, South Australia.

Rathnayaka, Kanchana and Momot, Konstantin and Volp, Andrew and Noser, Hansrudi and

Sahama, Tony and Schuetz, Michael and Schmutz, Beat (2009) Quantification of the

accuracy of MRI generated 3D models of long bones. In: 4th Asian Pacific conference of

biomechanics, 14 th to 16th April 2009, Christchurch, New Zealand.

Saunders, Nicole M. and Adam, Clayton J. (2009) The effect of insertion time on the axial

pullout strength of anterior vertebral body screws. In: Adelaide Centre for Spinal Research

(ACSR) - Spinal Research Symposium VII , 25-27 August, Barossa Valley, Adelaide, Australia.

Shillington, Mark and Adam, Clayton J. and Labrom, Robert D. and Askin, Geoffrey N. (2009)

A biomechanical investigation of anterior vertebral stapling. In: 13th International

Conference on Biomedical Engineering (ICBME 2008), 3-6 December, 2008, Singapore.

Young, Yun Wai and Lutton, Cameron J. and Meedeniya, Adrian C. B and Mackay-Sim, Alan

and Goss, Benjamin G. (2009) Reduction of Secondary Degeneration after Spinal Cord Injury

by Acute Delivery of Proinflammatory Growth Factors. In: Society for Neuroscience 2009, 17-

21, 2009, Chicago, IL . USA.

Book Chapter

Xiao, Yin and Fan, Wei and Bouwense, Stefan AW and Crawford, Ross W. (2009) The role of

periosteum : a neglected aspect of osteoporosis. In: Mattingly, Bilar E. and Pillare, Albert C.,

(eds.) Osteoporosis : Etiology, Diagnosis, and Treatment. Nova Science Publishers, Inc.,

Hauppauge, New York, pp. 235-249.

Journal Articles

Bolz, Katharina and Crawford, Ross W. and Donnelly, Bill and Whitehouse, Sarah L. and

Graves, Nicholas (2009) The cost-effectiveness of routine follow-up after primary total hip

arthroplasty. The Journal of Arthroplasty. pp. 1-6. (In Press)

[21]


Attachment 1 – Publications - Journal Articles continued…

Brown, Cameron P. and Bowden, Joshua and Rintoul, Llewellyn and Meder, Roger and

Oloyede, Adekunle and Crawford, Ross W. (2009) Diffuse reflectance near infrared

spectroscopy can distinguish normal from enzymatically digested cartilage. Physics in

Medicine and Biology, 54(18). pp. 5579-5594.

Chen, G. and Niemeyer, F. and Wehner, T. and Simon, U. and Schuetz, M. A. and Pearcy, M.

J. and Claes, L. E. (2009) Simulation of the nutrient supply in fracture healing. Journal of

Biomechanics, 42, pp.2575-2583.

Clements, Warren J. and Miller, Lisa and Whitehouse, Sarah L. and Graves, Stephen E. and

Ryan, Philip and Crawford, Ross W. (2009) Early outcomes of patella resurfacing in total

knee arthroplasty. Acta Orthopaedica.

Costain, Darren J. and Crawford, Ross W. (2009) Fresh-frozen vs. irradiated allograft bone in

orthopaedic reconstructive surgery. Injury. (In Press)

Conroy, Jon and Chawda, Mayur and Kaushal, Rishi and Whitehouse, Sarah and Crawford,

Ross W. and English, Hugh (2009) Does use of a “rim cutter” improve quality of cementation

of the acetabular component of cemented exeter total hip arthroplasty? Journal of

Arthroplasty, 24(1). pp. 71-76.

Frossard L, Tranberg R, Haggstrom E, Pearcy M, Branemark R (2009) Fall of a transfemoral

amputee fitted with osseointegrated fixation: loading impact on residuum. Gait and Posture,

30 (2). Pp. S151-S152.

Gregory, Shaun and Timms, Daniel and Tansley, Geoff and Pearcy, Mark J. (2009) A naturally

shaped silicone ventricle evaluated in a mock circulation loop : a preliminary study. Journal

of Medical Engineering and Technology, 33(3). pp. 185-191.

Hutmacher, Dietmar W. and Horch, Raymund E. and Loessner, Daniela and Rizzi, Simone C.

and Sieh, Shirly and Reichert, Johannes C. and Clements, Judith A. and Beier, Justus P. and

Arkudas, Andreas and Bleiziffer, Oliver and Kneser, Ulrich (2009) Translating tissue

engineering technology platforms into cancer research. Journal of Cellular and Molecular

Medicine, 13(8a). pp. 1417-1427.

Klein, Travis J. and Rizzi, Simone C. and Reichert, Johannes C. and Georgi, Nicole and Malda,

Jos and Schuurman, Wouter and Crawford, Ross W. and Hutmacher, Dietmar W. (2009)

Strategies for zonal cartilage repair using hydrogels. Macromolecular Bioscience, 9. pp. 1-10.

Klein, Travis and Malda, Jos and Sah, Robert and Hutmacher, Dietmar (2009) Tissue

engineering of articular cartilage with biomimetic zones. Tissue Engineering, 15(2). pp. 143-

157.

[22]


Attachment 1 – Publications - Journal Articles continued…

Li, Jian and Mareddy, Shobha R. and Tan, Dawn Meifang and Crawford, Ross W. and Long,

Xing and Miao, Xigeng and Xiao, Yin (2009) A minimal common osteochondrocytic

differentiation media for the osteogenic and chondrogenic differentiation of bone marrow

stromal cells in the construction of osteochondral graft. Tissue Engineering Part A. (In Press)

Little, Judith Paige and Tevelen, Gregory and Adam, Clayton J. and Evans, John H. and

Pearcy, Mark J. (2009) Development of a biaxial compression device for biological samples :

preliminary experimental results for a closed cell foam. Journal of the Mechanical Behavior

of Biomedical Materials, 2(3). pp. 305-309.

Mao, Xueli and Peng , Hui and Ling, Junqi and Friis, Thor and Whittaker, Andrew K. and

Crawford, Ross W. and Xiao, Yin (2009) Enhanced human bone marrow stromal cell affinity

for modified poly(L-lactide) surfaces by the upregulation of adhesion molecular genes.

Biomaterials, 30(36). pp. 6903-6911.

Mareddy, Shobha R. and Broadbent, James A. and Crawford, Ross W. and Xiao, Yin (2009)

Proteomic profiling of distinct clonal populations of bone marrow mesenchymal stem cells.

Journal of Cellular Biochemistry. (In Press)

Peng, Hui and Xiao, Yin and Mao, Xueli and Chen, Lan and Crawford, Ross W. and Whittaker,

Andrew (2009) Amphiphilic Triblock Copolymers of Methoxy-Poly(ethylene glycol)-b- Poly(L-

lactide)-b-Poly(L-lysine) for Enhancement of Osteoblast Attachment and Growth.

Biomacromolecules, In Press. (In Press)

Reichert, Johannes C. and Epari, Devakara R. and Wullschleger, Martin E. and Saifzadeh,

Siamak and Steck, Roland and Lienau, Jasmin and Sommerville, Scott and Dickinson, Ian C.

and Schutz, Michael A. and Duda, Georg N. and Hutmacher, Dietmar W. (2009)

Establishment of a preclinical ovine model for tibial segmental bone defect repair by

applying bone tissue engineering strategies. Tissue Engineering Part B Reviews.

Reichert, Johannes C. and Saifzadeh, Siamak and Wullschleger, Martin E. and Epari,

Devakara R. and Schütz, Michael A. and Duda, Georg N. and Schell, Hanna and van

Griensven, Martijn and Redl, Heinz and Hutmacher, Dietmar W. (2009) The challenge of

establishing preclinical models for segmental bone defect research. Biomaterials, 30(12). pp.

2149-2163.

Singh, Sanjleena and Dhaliwal, Navdeep and Crawford, Ross W. and Xiao, Yin (2009) Cellular

senescence and longevity of osteophyte-derived mesenchymal stem cells compared to

patient-matched bone marrow stromal cells. Journal of Cellular Biochemistry, 108. pp. 839-

850.

Tung, JP, Fraser JF, Wood P, Fung YL. (2009) Respiratory burst function of ovine neutrophils.

BMC Immunology, 10:25.

[23]


[24]


Attachment 2 – Media Release

[25]


Attachment 3 – Australian Government Research Grants 2009

Project Title Chief Investigator Grantor: 2009 Income Bilayered and Growth Factor-loaded Composite Scaffolds for the Guided Bi-Differentiation of Bone Marrow Stem Cells

A/Prof Yin Xiao Australian Research Council (ARC)

$ 88,456

Hyperpolarised Helium MRI to Quantify Regional Lung Damage and Ventilation for Improvement of Recruitment

Prof John Bell National Health & Medical Research Council

$ 45,509 Engineering Articular Cartilage with Zonal Structure and Function

Prof Dietmar Hutmacher

Australian Research Council (ARC) $ 196,061

Hyperpolarised Helium MRI to Quantify Regional Lung Damage and Ventilation for Improvement of Recruitment

Prof John Bell National Health & Medical Research Council

$ 45,509

The Next Generation of Biomaterials: In Vivo Assessment of Lumbar Spinal Fusion Biodegradable Interbody Cages

Dr Ben Goss National Health & Medical Research Council

$ 59,068 Development of a Smart Arthroscopy System and Prototype Probe for Joint Tissues

Prof Kunle Oloyede National Health & Medical Research Council

$ 115,455 Inter-Fragmentary Movement In Callus Formation In The Early Phase Of Fracture Healing

Prof Graeme Pettet Australian Research Council (ARC)

$ 122,430

Understanding the Biomechanical Effects of Fixation Strategies to Improve the Technology of Fracture Management

Prof Michael Schuetz Australian Research Council (ARC)

$ 95,557

Design And Fabrication Of An Engineered Bone Graft System (EBGS) By Combining A Composite Scaffold And Growth Factor Delivery System


Australian Research Council (ARC)

$ 122,430

Development and Characterization of a Technology Platform to Study the Mechanisms of Scaffold/BMP Augmented Large Segmental Bone Healing



$ 51,011 An Innovative System for Accurate Bending of Fracture Fixation Plates in Orthopaedic Surgery

Prof Prasad Yarlagadda


$ 30,097

TOTALS

$ 971,583

[26]


ACKNOWLEDGEMENTS

“The Medical Engineering Research Facility would like to acknowledge the

contributions to the 2009 Annual Report made by staff and researchers of the

Institute of Health and Biomedical Innovation (IHBI), the Faculty of Built

Environment and Engineering (BEE), other offices of Queensland University of

Technology (QUT), researchers and clinicians of The Prince Charles Hospital

(TPCH) and our industry partners Medtronic and Stryker”.

annual report 2009 - quteprints.qut.edu.au/32954/1/merf_annual_report_2009_for_publication.pdf ·...

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