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Annual Report 2008

Julius Center for Health Sciences and Primary Care

Annual Report 2008Julius Center for Health Sciences and Primary Care

UMC Utrecht

The Julius Center for Health Sciences and Primary Care is one of the twelve divisions of the

University Medical Center Utrecht (UMC Utrecht). It carries out scientific research, provides

education and offers expertise and facilities in the clinical health sciences field.

The Center aims to have a leading and acquisitive role in the enlargement and dissemination of

knowledge, particularly in the field of health sciences. This is done by carrying out groundbreaking

research on four disease-related themes and research methodology, by offering courses for (bio)

medical students, researchers and clinicians, and by providing academic primary care.

Disciplines represented in the Center are general practice, (clinical) epidemiology, nursing science,

medical technology assessment, public health, medical ethics, nutritional sciences and biostatistics.

In this annual report the reader will find information on activities, output and finances in 2008.

Contact information:

M. Donkervoort, PhD

Policy officer, research strategy


University Medical Center Utrecht

Visitors: Heidelberglaan 100, Utrecht, The Netherlands

Correspondence: Str.6.131, P.O. Box 85500, 3508 GA Utrecht, The Netherlands

URL: www.juliuscenter.nl

E-mail: [email protected]

3

Contents Introduction 7

Organization 15

Brief History 17

Organizational Structure 17

Research 19

Research Organization 21

Research Themes 32

Collaboration and Affiliations 43

Research Highlights 48

Education 51

Educational Organization 53

General Practice 57

Epidemiology 64

Public Health 74

Biostatistics 77

Medical Humanities 80

Nursing Science 82

Nutritional Science 85

International Activities in Education 87

Patient Care 91

Nutritional Sciences and Dietetics 93

Julius Center Health Care Leidsche Rijn 99

Unit Health Care Innovations 101

4 Annual Report 2008

Operational Support 105

Management Support 107

From CTSU to Julius Clinical Research and Research Support 108

Personnel and Finances 119

Personnel, Figures 121

Personnel, Listing 122

Financial Report 132

Research Projects 2008 137

Cardiovascular Diseases 139

Infectious Diseases 149

Cancer 154

Mental Health 157

Theoretical Epidemiology and Biostatistics 161

Miscellaneous 166

Clinical Trial Services Unit / Research Services 170

Data Management 174

Publications 2008 179

PhD Theses 181

International Refereed Publications 183

Professional Publications 212

Books and Book Chapters 216

Nederlandse Samenvatting 221

Introduction

‘Being selected as an AsiaLink PhD fellow is the best

thing that ever happened in my career and I am

looking forward to making it a success!’

Nirmala Bhoo Pathy,

PhD fellow AsiaLink Programme

Introduction 9

The Julius Center for Health Sciences and Primary Care has a simple

strategy. It endeavors to do everything necessary in order to excel within

research and teaching in health sciences. While sometimes our achieve-

ments in research may seem to dominate our profile, we are firmly con-

vinced that the fundament on which to build our scientific and health

care achievements is high-quality teaching. Teaching medical students

about primary care, public health and the principles and methods of

patient-oriented research; teaching MSc and PhD fellows how to set up

and conduct research projects that have relevance and impact; teaching

general practitioners the way to take best care of their patients and set

new standards for primary care. Our teaching tries to bring out the best

in our students by stimulating the development of their curiosity and

talents to learn and to achieve. As William J. Mayo said ‘One of the chief

defects in our plan of education is that we give too much attention to

developing the memory and too little to developing the mind’.

We aim to develop the critical minds required by modern health care

and clinical research. The present annual report aims to underline the

value we place on teaching by showing you some faces and views of

those who are at the ‘receiving end’. This involves our students, pupils

and fellows from the Netherlands and abroad, with a background in

medicine and other disciplines. We are privileged to be able to teach this

vibrant and ever changing community and are eager to simultaneously

benefit from what they are able to teach us.

During 2008, our organization underwent several changes that resulted

from a reflection on our strategies and organizational insights developed

over the previous years. Our line-organization was strengthened and

increased and responsibility was given to the coordinators of our five

research themes for defining their strategy and budgetary priorities. For

several years it has been clear that the success of our clinical trials and


the dedicated organization built for it would eventually require a reposi-

tioning of these activities relative to the other tasks of the Julius Center.

On the one hand, growth and, sometimes, hectic negotiations and busi-

ness development called for a larger degree of independence and less

interference with other priorities in the Center. On the other hand, it

was important to maintain the scientific stimulus and output from

major, randomized trials and access to its infrastructural resources. After

careful consideration, the Management of the Julius Center and the

Board of the University Medical Center Utrecht decided to transfer the

clinical trial activities to an independent Academic Clinical Research

Organization; Julius Clinical Research BV. The links between the Julius

Center and Julius Clinical Research BV remain close and the UMC

Utrecht is the majority shareholder in the new company. We believe that

this is the best way to move forward and to stay at the forefront of inter-

national clinical trials while also maintaining the fruitful interaction

between the trials and other scientific work in the Center.

The merger of the former University Center for Biostatistics in the Julius

Center also took place in 2008. This reflected the emerging view that

Biostatistics in Utrecht needs a more solid scientific foundation and aca-

demic home base while maintaining high quality consultation and

teaching, not only within the UMC Utrecht but also for other faculties

and departments at Utrecht University. To further accentuate the scien-

tific ambitions in the domain of biostatistics, a Chair of Biostatistics has

been established at the Julius Center for which candidates are currently

being sought. As Biostatistics enters the Julius Center, we see the depart-

ment of Nursing Science depart. Major changes in the financing of

Nursing Sciences’ educational activities made a reorganization inevitable

and it was judged that scientific research by the discipline would benefit

Introduction 11

from a decentralized position within clinical divisions of the UMC

Utrecht that have material patient care delivered by nurses.

Successes in education and research were continued throughout 2008.

A record number of students graduated from the general practice voca-

tional training and from the Master of Science program in

Epidemiology. The latter program is being organized in conjunction

with other UU epidemiologic groups and was positively evaluated in

2008 by the Accreditation Organization of the Netherlands and Flanders.

This guarantees the registration of the MSc exam by law and full com-

pliance with quality control standards. Also, in terms of numbers of

completed PhD theses, the Julius Center set a new record which will be

difficult to beat in the coming years. No less than 39 fellows defended

their PhD thesis with a staff member from the Julius center as (co-)

supervisor or co-promoter. For the fourth time, the Julius Center’s chair,

Rick Grobbee, became ‘PhD Supervisor of the Year’, passing a total of

over 100 PhD fellows whom he has guided successfully towards their

theses defense. Professor Yolanda van der Graaf occupied an honorable

third position among the University’s top supervisors in 2008.

This year, in terms of simple numbers, staff members from the Julius

Center were involved in 400 international scientific publications, 10 of

which were in journals with an impact factor above 20; five appeared in

the Lancet, four were in the New England Journal of Medicine and one

was in the Journal of the American Medical Association (JAMA).

Two important prizes, awarded in 2008, emphasized the Julius Center’s

scientific position. Professor Bert Brunekreef, jointly appointed by the

Julius Center and the Institute for Risk Assessment Sciences, Faculty of

Veterinary Medicine, received the prestigious Heineken Prize for

groundbreaking research in occupational epidemiology. The scientific

contributions to clinical epidemiology by Professor Rick Grobbee were


recognized with the award of the bi-annual Catharijne Prize and Julius

Center’s Dr Maroeska Rovers was awarded the Elisabeth von Freyburg

medal for most promising young scientist. While listing the successes of

individual staff members, the competitive appointment of Dr Yvonne

van der Schouw as Professor of Chronic Disease Epidemiology, as part

of the UMC Utrecht strategic chairs program, should also be mentioned.

The increased efforts of the Julius Center to further improve the quality

of its (inter)national teaching activities are exemplified by the publica-

tion of the textbook ‘Clinical epidemiology. Principles, methods and

applications for clinical research’, in 2008. This book was written by Rick

Grobbee and Arno Hoes and includes contributions by many other staff

members from the Center.

While the Julius Center values its position in the University Medical

Center Utrecht, we are also very conscious of the international nature of

our teaching and research. Our emphasis on strong and productive

international relations was expressed in 2008 by the establishment of

two visiting chairs in Cardiovascular Disease Epidemiology. Dr Stephen

MacMahon, from the George Institute for International Health, Sydney,

Australia, and Dr Dan Levy, Director Framingham Heart Study,

Framingham and Boston University, US, were appointed to take up these

positions. Both have been appointed for a period of four years and, dur-

ing this time, they will regularly visit the Netherlands, provide teaching

and stimulate collaborative projects. Finally, as recommended by the

board of supervisors of the ‘Prince Claus Chair in Development and

Equity’, Utrecht University has appointed Professor Irene Agyepong as

holder of the Chair until August 2010. The Julius Center is pleased to

host the Prince Claus Chair for this period and looks forward to collabo-

ration with Professor Agyepong to promote health scientific research

and evidence based medicine in Ghana.

Introduction 13

It is customary to highlight academic achievements when introducing

the annual report of an academic department such as the Julius Center.

However, an important factor in the achievement of any successes is the

contribution and dedication by the people in all layers of the organiza-

tion. First and foremost, the Julius Center wants to be an inspiring and

fun place to be. We promote the expression of talent and determination

by our staff within the Center as much as outside of it. Perhaps the best

example of this attitude is provided by Chantal Boonakker who com-

bines 20 hours of training with 20 hours of PhD work at the Julius

Center and who won a bronze medal for her performance at the 2008

Paralympic Games in Beijing. All of us have gifts and competences and,

together, they make our Center what it is today. We set our academic

standards high and focus on individual results but always remain aware

of the value of being part of the larger community of the Julius, of the

University Medical Center Utrecht at large and our responsibilities

towards science and healthcare in the Netherlands and abroad.

The management team of the Julius Center for Health Sciences and

Primary Care

Yolanda van der Graaf, manager education

Diederick E. Grobbee, chair, medical manager

Arno W. Hoes, manager research

Anne-Marie Laeven, manager business administration

Introduction 15

Organization

‘The ratio of We’s to I’s is the best indicator

of the development of a team’

Jaap Trappenburg, PhD fellow and active member

of Julius staff association

Organization 17

Brief History

The Julius Center was established on 16 December 1996. It was founded

on the basis of the previous departments of epidemiology and public

health and on the clinical epidemiology’s hospital unit. It was originally

called the Julius Center for Patient Oriented Research. Since then, both

its scope and size have markedly increased and this is reflected by the

number of disciplines represented within the Julius Center. In 1999 the

department of General Practice merged with the department of patient-

oriented research to become the Julius Center for Patient-Oriented

Research and General Practice. In 2002, the department of Nursing

Science and the Nutritional Sciences group joined the Center to become

the current ‘Julius Center for Health Sciences and Primary Care’. In 2008,

Biostatistics was added to the center, by integrating the former Center

for Biostatistics, to reinforce education and research in this area.

Changes in educational financing led to a reorganization of nursing

sciences and, as a result, the discipline left the Julius Center at the end of

2008, to be re-allocated at several clinical divisions of the UMC Utrecht.

In response to the increasing challenges facing clinical research in the

21st century, the clinical trial unit was incorporated into a private com-

pany, Julius Clinical Research, which is dedicated to the performance of

large-scale trials.

Organizational Structure

The organizational structure can be found inside the cover.

Organization 19

Research

‘Research is like a triathlon; a challenging race with

variation requiring perseverance and commitment’

Margriet de Beus, PhD fellow Julius Center

Research 21

Research organization

The University Medical Center Utrecht has formulated seven main

research themes. These fit into a matrix with four disease-related themes

on the horizontal and three methodological themes on the vertical axes.

The Julius Center’s main contribution to the UMC Utrecht’s total body

of research is through the research theme ‘Epidemiology’. With rare

exceptions, all of the Center’s research activities can be classified as ‘clini-

cal epidemiological’ research, i.e. etiologic, diagnostic, prognostic and

intervention research with relevance for patient care. Building upon this,

the Julius Center contributes to all four disease-related areas of research:

cardiovascular disease, infection & immunity, cancer, and mental health.

In addition, there are strong links with the UMC Utrecht’s other two

methodological research themes: ‘Imaging sciences’ and ‘Genetics’.

The Julius Center’s research activities focus on five research themes, i.e.

the same four disease-related areas as the UMC Utrecht (cardiovascular

disease, infection & immunity, cancer, and mental health) and one

methodological theme (Theoretical Epidemiology & Biostatistics).

Within these themes, there is further focus on subfields, such as research

on (etiology and prognosis of) diabetes mellitus as part of the cardiovas-

cular disease theme or on the effects of vaccinations within the infection

& immunity theme.

All five research themes are headed by one research coordinator or two

for the largest theme, cardiovascular diseases. Importantly, the research

activities of the (clinical or methodological) disciplines represented in

the Julius Center (Clinical Epidemiology, General Practice/Primary

Care, Public Health, Biostatistics, Medical Technology Assessment,

Medical Ethics, Nutritional Sciences and Nursing Sciences) are also

incorporated within these five research themes and not separately.


Themes

Dis

cip

lines

CardiovascularDiseases

InfectiousDiseases

Cancer

MentalHealth

TheoreticalEpidemiology

and Biostatistics

Cli

nic

al

Ep

idem

iolo

gy (

CE)

Gen

era

l Pra

ctic

e (

GP)

Pu

bli

c H

ealt

h/M

TA/

Eth

ics

(PH

/MTA

)

Nu

trit

ion

al

Sci

en

ces

(Die

teti

cs, D

T)

Bio

stati

stic

s

Nu

rsin

g

Sci

en

ce (

NS)

The research methods for all of these disciplines can be broadly charac-

terized as (clinical) epidemiological and this was one of the main rea-

sons for these disciplines being combined within the Julius Center. The

research activities can, thus, be represented by a matrix structure, in

which the horizontal axis comprises the five research themes and the

disciplines are depicted in the vertical axis. The Center’s policy is to con-

centrate its research as much as possible on the matrix’s overlapping

areas so that each of its disciplines benefit most from the Center’s scien-

tific and clinical expertise and the UMC Utrecht’s scientific themes as a

whole are strengthened.

The Julius Center has a formalized link with the interfacultary Institute

for Risk Assessment Sciences (IRAS), environmental and occupational

Research 23

epidemiology at UU. This has been embodied by the joint appointment

of Prof Bert Brunekreef and honorary appointee Prof Dick Heederik.

There is also collaboration with other epidemiological research groups

at Utrecht University, in particular with the Pharmaco-epidemiology

group (from the Utrecht Institute for Pharmaceutical sciences) and

Veterinary Epidemiology groups. Moreover, collaborations were recently

strengthened with health/scientific institutions in the vicinity of the

University Medical Center, such as the National Institute for Public

Health and the Environment (in Dutch: RIVM) and the Municipal

Health Authority (in Dutch: GGD) in Utrecht.

In addition to the acquisition and conduct of its own research projects,

either independently as an institute or in collaboration with other

research groups, a major responsibility of the Center is to provide meth-

odological advice and to support clinical research in virtually all of the

University Medical Center’s departments. Staff members act as consul-

tants for research methods on a range of clinical investigations both

within and outside the UMC Utrecht. The Center also plays a pivotal

and formal role in the quality assurance of randomized trials performed

in the UMC Utrecht. These are important and expanding activities for

the Julius Center. For many clinical departments, the intense and contin-

uous interaction with epidemiology has resulted in joint staff appoint-

ments, including the departments of anesthesiology, cardiology, cardio-

thoracic surgery, dermatology, internal medicine, neurology, pediatrics,

psychiatry, and radiology.

CohortsThe Julius Center coordinates and participates in several large research

cohorts. These cohorts are an important base for research and provide

ample opportunities for obtaining financial research support. Moreover,

the projects of the GP-network Utrecht and the Utrecht Health Project are

intended to create an infrastructure in which research questions on efficacy

and effectiveness of health care and effects of (local) health care policy can

be answered. The latter is of major importance for increasing the expertise

in the areas of health care improvement, extramural health care and gener-

al practice.

The major cohorts are:

ADDITION

The ADDITION (Anglo-Danish-Dutch study of Intensive Treatment In peOple

with screeN-detected diabetes in primary care)-Netherlands cohort consists

of 498 patients with screen-detected type 2 diabetes mellitus, diagnosed in

2002-2004 during a population screening among 57,000 people in the

south-western part of the Netherlands. The initial purpose of the study is to

investigate the effects of a multifactorial, intensified treatment on cardio-

vascular mortality and morbidity in a randomized design. After finishing

the trial in 2009, the cohort will be followed up with an investigation into

different aspects of the ‘diabetes career’ of screen-detected diabetes

patients.


AGIS Health database

The AGIS Health Database is a registry of a health insurance company and

contains all health care procedures carried out in the last ten years involv-

ing 1.2 million health insured persons. Data is preserved on health care pro-

cedures by all contracted health care providers such as general practitio-

ners, specialists, physiotherapists, pharmacists, midwives and hospitals.

Besides data on health care procedures in primary (consultations, referrals,

prescriptions) and secondary care (consultations, prescriptions and

Diagnostic-Treatment Codes), a number of personal characteristics are doc-

umented, such as date of birth and gender. The insured persons are repre-

sentative of the Dutch population. Data from this large cohort offers

opportunities for all kinds of epidemiological research, but the main pur-

pose is to improve knowledge on health care consumption and interaction

between primary care, secondary care and public health. Data is also avail-

able to support health care management strategies and to evaluate

improvements in quality of care.

ARYA

The Atherosclerosis Risk in Young Adults (ARYA) study is an unselected birth

cohort of 750 persons born between 1970 and 1973 in and around the city

of Utrecht. Its research focus is on early life determinants of later life car-

diovascular disease. At birth, participants had elaborate birth data regis-

tered at the Municipal Health Service in Utrecht and they were followed up

into young adulthood. In 1999, participants underwent elaborate cardio-

vascular disease risk profiling, including classical cardiovascular disease risk

factors as well as elaborate non-invasive arterial wall measurements.

Research 25

DOM

The DOM cohort (Doorlopend Onderzoek Morbiditeit en Mortaliteit =

Ongoing Study on Morbidity and Mortality = Diagnostisch Onderzoek

Mammacarcinoom) is a cohort of 50,000 healthy women, living in Utrecht

and surroundings. They were recruited from among breast cancer screening

participants, aged between 40 and 70 years when recruited between 1974-

1986. The purpose of the DOM study is to identify risk factors for several

chronic diseases, especially (breast) cancer.

Baseline measurements included a short medical examination and extensive

lifestyle and medical questionnaires. Overnight urine samples were collect-

ed and stored at -20°C.

Electronic patient records communication disorders

All children referred to our tertiary care centre for multidisciplinary evalua-

tion of speech and language problems undergo a structured evaluation by

an otolaryngologist, audiologist, speech therapist and a child psychologist.

All data is then fed into their electronic patient records. Currently, about

500 children are included.

EPIC-NL

EPIC-NL is the Dutch contribution to European Prospective Investigation

into Cancer and Nutrition (EPIC). EPIC-NL (www.epic.eu) is a merger of the

Prospect-EPIC cohort (coordinated by the Julius Center) and the MORGEN-

EPIC cohort (coordinated by the National Institute of Public Health and the

Environment (RIVM), Bilthoven). It is a cohort of over 40,000 men and

women from Amsterdam, Doetinchem, Maastricht and Utrecht and sur-

roundings, aged 20-70 years at recruitment in 1993-1997. The purpose of

this study is to assess the relationship between nutrition and cancer and

other chronic diseases. Participants filled out lifestyle and medical question-


naires and extensive food frequency questionnaires. Blood samples were

taken, fractionated and stored at -196°C for all participants.

HNU

The HNU (Huisartsen Netwerk Utrecht = Utrecht General Practice Network)

was founded in 1989 and is a collaboration between the General Practice

department of the Julius Center and around 38 general practitioners work-

ing in six primary health care centers in the Utrecht area. Approximately

60,000 patients are enlisted with these centers. Data on all primary care

consultations (including the ICPC coded diagnosis), ATC-coded prescriptions

and referrals of these patients have been encoded in the database since

1992. GPs receive ongoing training in ICPC coding to ensure high quality

coding. The primary goal was to set up a network of general practices that

could provide valid and detailed routine care data on a primary care cohort

for observational studies. Nowadays, the HNU has a large, centralized data-

base containing observational data on the patients enlisted from 1995 up

until 2007.

IJSCO

The IJSCO (IJsselstein Screening for Central Obesity to detect metabolic syn-

drome) cohort consists of 473 people with screen-detected metabolic syn-

drome (MetS). The screening among approximately 12,000 inhabitants of

IJsselstein, 20-70 years old on July 1st, 2006 and not known to have cardio-

vascular risk factors, started with self-measurement of waist circumference

using a mailed tape measure. People with screen-detected MetS were

advised to visit their general practitioner. Approximately half a year after

the screening, they were followed by means of data collection from GP’s

medical records to investigate the normal course of events following

screening for MetS. After approximately three years, all patients will be

measured again.

Research 27

Netherlands Amniotic Fluid (NAF) cohort

The Netherlands Amniotic Fluid (NAF) cohort is an ongoing birth cohort

focusing on the role of amniotic fluid inflammation in relation to respirato-

ry tract infections during the first years of life. Healthy term infants are

studied for the NAF study. Data collected at birth comprises: obstetric histo-

ry, amniotic fluid cytokine measurements, Toll-like receptor responses,

genetic polymorphisms and neonatal lung function. During follow-ups,

daily respiratory symptoms are noted in a parental log and nasal swabs are

taken for virology testing during each respiratory episode during the first

year of life. The parents are instructed to take the diary to the general

practitioner, who is subsequently asked to report the ICPC diagnosis.

Currently, about 500 infants are included.

PCR-MN

PCR-MN (Psychiatric Case Registry Midden Nederland) is an anonymous psy-

chiatric case registry that contains information on all patients who have

been treated in one of the mental health care institutions in the central

region of the Netherlands. It is one of the four regional psychiatric regis-

tries that are supported by the Ministry of Health. The primary aim of the

database is to provide and analyze epidemiological data on mental health

care, to provide management support and to improve quality of care. All

major institutions for mental health care in the central region of the

Netherlands participate in the registry. From 1999 onwards, data (patient

characteristics, DSM IV diagnosis, referring centre, type of care) for approxi-

mately 120,000 patients with over 380,000 diagnostic codes, who were

treated for mental health problems, has been included in the database.


PIAMA

The PIAMA (Prevention and Incidence of Asthma and Mite Allergy) birth

cohort includes circa 4,000 children who have been followed for 8 years

since birth. It is a multi-centre study including IRAS/Julius Center, National

Institute of Public Health and the Environment (RIVM), Erasmus University

Medical Center Rotterdam, University Medical Center Groningen and

Sanquin/CLB Amsterdam. The study was started in 1996 and its purpose is

to investigate the occurrence of asthma and allergy in young children, as

well as lifestyle and environmental risk factors for these diseases. At several

points in time, data was collected on exposure and health status. Blood

samples were collected in a sub sample of the children.

PREDICT

This is a prospective study in which consecutive general practice attendees

in six European countries are recruited and followed up after six and twelve

months for the prevalence of depression. The Dutch part is coordinated by

the Julius Center. Its purpose is to develop a risk score for use by general

practitioners to predict the onset and maintenance of depression.

Recruitment was started in 2003 and participants were 18-75 years old.

Over 10,000 participants were included, of which over 1,000 participants

were in the Netherlands.

PROVIDI

PROVIDI is a cohort of ca. 16,000 patients who have undergone a chest

multislice Computed Tomography (msCT) scan for diagnostic reasons. The

purpose of the cohort is to investigate the extent to which unrequested

imaging findings are of prognostic relevance for the occurrence of several

relevant diseases, other than the diagnostic that the CT was originally indi-

cated for.

Research 29

SMART

The SMART (Second Manifestations of ARTerial diseases) cohort started in

1996. It is an ongoing, prospective, single-center cohort study of patients

with cardiovascular risk factors or clinically manifest arterial disease. The

purpose is to screen these patients for vascular problems elsewhere in the

body. Consecutive patients aged 18 to 80 years, referred to the University

Medical Center Utrecht (UMCU), with manifest arterial disease or a cardio-

vascular risk factor underwent vascular screening including a questionnaire,

blood chemistry, and ultrasonography. After this screening, all patients fill

out a biannual questionnaire in order to collect information on cardiovas-

cular morbidity and mortality as well as diabetes mellitus end-points.

SMART includes over 8,200 patients with more than 10 years of follow-up.

In 2008, SMART-2 screening commenced. All patients screened in the past

have been approached again to take part in this second screening. The aim

of this second vascular screening is to study the course of atherosclerosis

and vascular risk factors in time and evaluate the impact of a possible earli-

er treatment. In 2008, more than 200 patients had been screened, accord-

ing to this SMART-2 protocol.

Utrecht Health Project (LRGP)

The Utrecht Health Project (or Leidsche Rijn GezondheidsProject (LRGP) is a

population study of residents of the Leidsche Rijn, Utrecht area, who have

been invited through their GPs working in the academic Primary Healthcare

Centers in the area. The purpose of this study is to enable research on the

impact of changes in health care policy, developments in community and

public health and determinants - e.g. life style, behavioral, biological and

genetic - of health and disease during lifetime, as well as quality manage-

ment of (primary) health care itself. Until now 10,000 (of 25,000) inhabit-

ants have given informed consent, Individual Health Profiles (IGP) have

been mad, and blood samples, ECG and spirometry data has been collected


at recruitment. Follow-up data (on average 5 years now) is collected

through continuous linkage with the computerized medical files recorded

by trained general practitioners. Data on diagnoses, prescriptions and refer-

rals of all 25,000 inhabitants is encoded in the database and coupled with

intake IGP data of those having given informed consent.

Whistler

Whistler (Wheezing Illnesses Study in LEidsche Rijn) is a satellite cohort of

the Utrecht Health Project. Participants are newborns to inhabitants of

Leidsche Rijn. Whistler was originally initiated to study early life predictors

of (lower tract) respiratory disease in childhood. The focus has now expand-

ed to include cardiovascular disease research questions as well. Recently,

the milestone of 2,000 included newborns was reached in Whistler. The ulti-

mate purpose is to follow participants up until adulthood.

Extensive descriptions of cohorts and related websites can be found at:

http://www.juliuscentrum.nl/julius/Research/cohorts/

Research 31


Research Themes

Cardiovascular Diseases

The Cardiovascular Diseases research line is one of the four disease-

based research lines at the Julius Center, which coincides with the UMC

defined, disease-based field of interest; Cardiovascular Disease. It is the

Julius Center’s largest research line. The research within this line uses

approaches that include the full range of epidemiological research meth-

ods, such as multi-centered randomized controlled trials to study the

effects of preventive and therapeutic interventions and cohort, case-

control and cross-sectional studies. The research focuses on the causes,

diagnosis, prognosis and therapy of common cardiovascular diseases.

Cardiovascular research line is centered around several following themes

with dedicated staff.

1 Early origins of vascular disease. Within this theme a research

programme started in 2008 entitled ‘From biomarker discovery to

primary prevention in early life: an UMC Utrecht joint action for the

prevention of cardiovascular disease’. In this project, highly

specialized cardiovascular knowledge is made accessible for primary

prevention. In cohorts of children and patients with varying degrees

of atherosclerosis markers, of inflammation, fat metabolism,

coagulation and immunologic parameters will be measured. The

purpose is to stratify people at a young age into high and low risk

individual using these measures. The project is coordinated by the

Julius Center and conducted in collaboration with the divisions

Pediatrics, Heart & Lungs, Internal Medicine & Dermatology,

Neurosciences, and Women & Baby.

2 Endocrinology of vascular disease. Within this theme, in 2008 Dr.

Yvonne van der Schouw was appointed Professor of Chronic Disease

Epidemiology. This will boost the further development of this

research theme to determine the role of menopause (cause or effect)

in relation to development of atherosclerosis and cardiovascular

disease risk. Furthermore, an important trial on the supplementation

of testosterone was published in JAMA in 2008.

3 International intervention studies. In 2008 several trials ended with

publications in New England Journal of Medicine; one on the

relation of tibolone treatment and fracture rate in postmenopausal

woman (LIFT) and one on the effect of blood pressure and glucose

lowering on vascular risk in patients with type II diabetes

(ADVANCE). Furthermore, a multicenter international polypill trial

started in 2008 in asymptomatic high risk subjects using a network of

international collaborators.

4 Diagnosis and prognosis of vascular disease in primary care. The

general practitioner is the gatekeeper within the Dutch health care

system. It is of utmost importance, but also sometimes extremely

difficult, to arrive at appropriate diagnoses in primary care in order

to further improve patient management. Diagnostic studies in

primary care are, therefore, an important research topic at the Julius

Center, also in the cardiovascular research line. In 2008, the AMUSE

(Amsterdam Maastricht Utrecht Study on thromboEmbolism) study

was finalized. The AMUSE study, evaluated the safety and efficiency

of using a clinical decision rule including a point-of-care d-dimer

assay in patients suspected of deep vein thrombosis of the leg. The

study showed that a diagnostic management strategy in primary care

by using a simple clinical decision rule and a point-of-care d-dimer

Research 33


assay reduces the need for referral to secondary care of patients with

clinically suspected DVT by almost 50% and is associated with an

acceptably low risk for subsequent venous thromboembolic events.

The diagnostic prediction rule has been incorporated into the

guideline on deep vein thrombosis for general practitioners in The

Netherlands. Similar diagnostic studies are ongoing in patients

suspected of myocardial infarction/acute coronary syndrome and

pulmonary embolism.

5 Vascular complications of type 2 diabetes mellitus in primary care.

In 2008, Julius Center investigators showed that it is possible to

reduce cardiovascular risk in patients with diabetes within 1 year

through intensive multifactor treatment. The study showing this was

picked up by ACP Journal Club of the American College of

Physicians – American Society of Internal Medicine, a medium to

help internists keep up to date by abstracting high quality research

from key journals of relevance to internal medicine. Care for type 2

diabetes patients is an important task for the general practitioner.

Another study showed that it is feasible, safe and effective to organize

care by delegating routine diabetes care to a practice nurse, combined

with computerized decision support and feedback. Funding was

obtained from the Netherlands Organization for Scientific Research

to start a study to assess whether reducing the number of visits for

diabetes patients from 4 to 2 per year has no adverse effects on

health.

6 Prediction of future vascular disease in secondary care. One of the

Julius Center’s cohorts is the Second Manifestations of ARTerial

disease (SMART) cohort. This unique cohort of patients at high risk

of cardiovascular disease (CVD) started in 1996. All patients referred

to the University Medical Center in Utrecht (UMC Utrecht) with

either a risk factor for CVD (hypertension, hyperlipidemia, diabetes)

or clinically manifest vascular disease (ischemic cerebral disease,

asymptomatic stenosis of the internal carotid artery, myocardial

infarction, angina pectoris, abdominal aortic aneurysm, intermittent

claudication) are eligible for inclusion in the study. Patients undergo

an extensive screening programme to detect asymptomatic

atherosclerotic lesions and to identify risk factors. Then, a

multidisciplinary team formulates an evidence-based treatment plan,

to reduce the patient’s risk of future cardiovascular events. This

treatment advice is sent to the patient’s general practitioner and to

his or her treating hospital specialist. Every 6 months patients are

asked to report, by mail, whether they have experienced or received

treatment for a vascular event in the last 6 months. In 2008, 5 PhD-

theses resulting from the SMART study were defended successfully.

One of these evaluated the SMART screening programme. For

patients who are not enrolled in a dedicated screening programme,

many risk factors are not systematically documented. Screening alone

is insufficient however for adequate treatment of these high-risk

patients and more intensive monitoring and follow-up is necessary.

Another thesis reported on the contribution of vascular diseases in

the development of brain atrophy and cognitive decline. In 2008, the

SMART-2 project started, in which patients enrolled in SMART are

screened for the second time. The main purpose of SMART-2 is to

study the course of atherosclerosis and risk factor development over

time, and to study effects of the treatment that was initiated on these

patients.

In 2008 research within the other themes (7) Diagnosis and Prognosis of

atherosclerosis, (8) Prevention of complication after cerebral vascular

Research 35


disease in secondary care and (9) Epidemiology of haemophilia in sec-

ondary care was continued with considerable scientific output and suc-

cess in aquiring grants.

Infectious Diseases

Infectious diseases research at the Julius Center is centered around four

topics:

1 Prevention, diagnosis and prognosis of respiratory tract infections.

This research is mainly positioned within the primary care and Ear

Nose and Throat areas. An investigation, for example, may take place

into the extent to which certain patient characteristics predict an

abnormal and serious clinical progression of bronchial infections and

what the consequences for treatment and patient advice are. In

addition, antibiotic use and indications for prescribing in general

practice are being studied, as is the efficacy of prednisone treatment

in patients with persistent complaints of sinusitis. This research has

been expanded to include the development of asthma and allergy, in

relation to exposure to infectious agents and other environmental

determinants, both in young children and in occupationally exposed

subjects.

2 Efficacy (and cost-effectiveness) of vaccination strategies. In

collaboration with the department of Pediatric Immunology, the

National Vaccine Institute and pharmaceutical industries, an

increasing number of vaccination studies have been executed and are

ongoing. In addition to these studies, the role of confounding in

determining vaccination efficacy is also investigated. Currently, this

research group is heading the CAPITA study, in which 85,000 elderly

people will be randomized to an investigational 13-valent conjugate

pneumococcal vaccine or placebo to determine the efficacy of this

vaccine in preventing community-acquired pneumonia caused by

vaccine-specific pneumococcal serotypes.

3 Mathematical modeling of infectious diseases. In collaboration with

the Mathematical Institute of the University Utrecht and the National

Institute of Health and Environment, the dynamics (and prevention

of acquisition) of multi-resistant bacteria and influenza within

hospitals and the community at large is being investigated, as well as

potential effects of interventions. In 2008, intensified collaborations

between the National Institute of Health and Environment, the

Mathematical Institute, the Veterinary Faculty and the Julius Center

resulted in the creation of the Utrecht Center for Infectious Disease

Dynamics.

4 The effects of nosocomial infections and transmission of antibiotic-

resistant bacteria on patient outcome. The attributable mortality of

ventilator-associated pneumonia is investigated and the Julius Center

coordinates an international cluster-randomized trial in European

ICUs to determine the efficacy of several approaches to reduce the

transmission of antibiotic-resistant bacteria.

Cancer

Cancer research at the Julius Center has a strong focus on the etiology,

early diagnosis and screening of hormone dependant cancer, predomi-

nantly in women. Cancer is a serious health threat in the Netherlands,

with approximately 30,000 new cases a year in women. In 2008, for the

first time, more people died from cancer than from cardiovascular dis-

eases. However, the known causes of cancer barely explain 30% of all

cases encountered. An explanation for this rather low percentage may be

sought in the fact that environmental and hormonal factors are predom-

inantly studied without any consideration to genetic predisposition.

Cancer etiological research within the Julius Center strongly focuses on

Research 37


the interaction between genes, hormones and lifestyle habits. For the

study of genetic determinants or gene-environmental interactions, the

Julius Center has access to biological material originating from two

large-scale on-going population-based cohorts, DOM and EPIC-NL,

which is a merger of the two Dutch cohorts participating in the

European Prospective Investigation into Cancer and Nutrition:

Prospect-EPIC and Morgen-EPIC.

For studies of the optimal (early) diagnostic and (clinical) follow-up

procedures in cancer patients, collaboration has been established with

clinicians from other departments of the University Medical Center in

Utrecht. Examples are the COBRA and MONET studies, both assessing

optimal diagnostic and therapeutic procedures in women with non-

palpable breast diseases. Studies to assess ‘quality of life’ in the daily care

of cancer patients also fall into the domain of the cancer research at the

Julius Center.

There is close cooperation with the Faculty of Medicine’s department of

epidemiology and public health at Imperial College in London, UK,

where the head of the cancer research line at the Julius Center, Petra

Peeters, has been appointed Professor for one day/week.

Mental Health

The Julius Center’s psychiatric epidemiology section studies psychiatric

disease and related co-morbidity in primary care and the population at

large. Mental illness represents a sizeable proportion of the global bur-

den of disease in the general population, but is only partly presented to

health care professionals. Major psychiatric disease represents 5% of the

prevalent morbidity in primary care, with an annual prevalence of 125

per 1000 patients. A substantial part of minor psychiatric morbidity is

presented in relation to somatic disease or functional syndromes or

expressed through excessive consultation frequency of unexplained

functional syndromes. Mental illness - though closely linked to somatic

ill-health – is traditionally studied in isolation. The psychiatric epidemi-

ology section focuses on the study of somatic - psychiatric comorbidity,

with the following themes:

1 The presentation of depression in primary care and its association

with somatic disease such as dementia, diabetes, gastro-enterological

and vascular disease.

2 Functional disease and somatoform disorders: presentation,

determinants and treatment in primary care.

3 Psychiatric morbidity in relation to socio-demographic context and

consultation patterns.

The common background hypothesis is that somatic and psychiatric

disorders share an overlapping etiology and that this overlap has social

and psychological as well as physiological components. Our assessments

typically aim to characterize individuals at several levels (psychological,

physical and physiological).

These themes are studied on the various levels at which disorders mani-

fest themselves:

- The general population, by using existing and developing sampling

frames such as LRGP (Leidsche Rijn Gezondheidsproject), NEMESIS

(Netherlands Mental Health Survey and Incidence Study), AGIS health

database and others.

- Primary health care, in primary care networks such as the Utrecht

General Practitioners Network (In Dutch: HNU (Huisartsen Netwerk

Utrecht), PREDICT, Utrecht Health Project (in Dutch: Leidsche Rijn

Research 39


Gezondheids Project) and the database of Emergency Primary Care

service in the Gelderse Vallei area.

- Populations of people with reported mental illness such as those

registered in our psychiatric case registry (PCR-MN).

- Populations of people with reported somatic illness, such as samples of

cardiovascular compromised patients (SMART), (pre)diabetic patients

(UDES), and medication-using people (PHARMO).

This approach of studying the phenomenon of somatic psychiatric

comorbidity at various levels of the health care system is unique. From a

clinical point of view, it will yield information on the etiology and prog-

nosis of somatic-psychiatric co-morbidity and allow preventive inter-

ventions. It will also facilitate evaluation of the patient flow through the

mental health care system and its effectiveness

Most research projects are carried out in collaboration with partners

within primary or secondary care health care: primary care physicians,

secondary care centers for psychiatry, neurology and gastro-enterology,

often in cooperation with other (international) academic centers.

Theoretical Epidemiology and Biostatistics

Besides more applied studies on improving insights in the etiology, diag-

nosis, prognosis and therapy of specific disorders, the Julius Center also

aims to further develop the theory and methodology of the discipline

itself. The section; Theoretical Epidemiology and Biostatistics conducts

studies aiming to improve existing methods and develop innovative

methods for design and analysis of (clinical) epidemiological studies.

The section focuses on the following themes:

- Developing innovative designs for diagnostic and prognostic

(prediction) research.

- Developing innovative methods for quantifying the true or added

value of (new) diagnostic and prognostic tests or biomarkers in a

multivariable clinical context.

- Developing innovative methods for validating and updating so-called

clinical prediction rules.

- Testing and improving methods for dealing with missing values in

epidemiologic research.

- Investigating innovative methods for meta-analysis and individual

patient data-analysis of etiologic and therapeutic studies.

- Development of models to combine data from randomized and

observational studies including genetic information, for estimating

(long term) prognosis according to specific patient characteristics in

addition to treatment effects.

- Developing and investigating methods for sequential analysis in

randomized trials, cumulative meta-analysis, observational

epidemiological and genetic studies, to increase their efficiency and

safety.

- Developing and investigating methods to adjust for confounding in

observational studies, like propensity scores and instrumental

variables.

- Investigating methods for the analysis of longitudinal data.

Notably, the improvement of methods for the design and analysis of

multivariable diagnostic and prognostic research is unique. Most

research in this field focuses on single test or (bio/genetic) marker evalu-

ations, rather than evaluations in a clinical context, accounting for other

test results. The methodology for modeling data from randomized and

non-randomized studies combined is also in its infancy. This type of

Research 41


research is situated at the crossroad of clinical epidemiology and medical

technology assessment.

All of the above methodological themes are not only studied on a purely

theoretical level, but are also applied by using empirical data from vari-

ous medical disciplines, notably from our four disease-oriented sections.

For example, data is used from the above-mentioned LRGP (Leidsche

Rijn Gezondheidsproject), the Predict study and the AMUSE studies on

the diagnosis, prognosis and treatment of deep vein thrombosis and

pulmonary embolism, as well as from various other large ongoing stud-

ies in the UMC Utrecht such as the SMART study. It may be obvious

that the results of our methodological studies do not only serve the clin-

ical domains studied, but may serve all medical domains in which diag-

nosis, prognosis and therapy, for example, are at issue.

Most methodological projects are carried out in close collaboration with

other clinical departments from the UMC Utrecht. Other epidemiologi-

cal and (bio) statistical departments from national and international

academic centers are also consulted, such as the Utrecht University,

Academic Medical Center Amsterdam, Erasmus Medical Center

Rotterdam, Dutch National Institute for Health and the Environment,

Vanderbilt University (USA), Harvard University (USA), Oxford

University (UK), and McGill University (Canada).

Research 43


Collaboration and affiliations

Collaboration is of major importance in research, both within the UMC

Utrecht and on a national and international basis. Collaboration leads to

the bundling of both expertise and data that no single institute could

produce on its own and, as a consequence, quality and the impact of the

research output increase. The annual citation analyses of the UMC

Utrecht have repeatedly shown that publications resulting from interna-

tional collaborations have significantly higher citation score than aver-

age UMC Utrecht publications.

The Julius Center has a large network of collaborations and - more

structural - affiliations. Over 50 persons have their personal names

attached to the center by means of an honorary appointment. Within

the UMC Utrecht, combined staff appointments have been established

with many clinical disciplines in order to ensure close contact with clini-

cal practice both in the formulation of research questions, conducting

research and implementation of acquired knowledge. The Utrecht

region offers excellent opportunities for collaboration and close links

exist with all epidemiology research groups within Utrecht University,

including IRAS (see below), Pharmacoepidemiology (Utrecht Institute

for Pharmaceutical Sciences) and Veterinary Epidemiology groups and

also with researchers at the Mathematical Institute and from the faculty

of Social Sciences. Also, there are structural relations with the National

Institute for Public Health and the environment (RIVM). One of the

ways in which the collaboration is expressed is the Utrecht University

research focus area Epidemiology. In 2008 funding for this focus and

mass area was used to initiate a Center for Infectious Disease Dynamics,

in which the RIVM also participates.

By nature of its scientific and educational activities, the Julius Center’s

‘playing field’ is the world. Not only is research being published in inter-

national peer-reviewed journals, but an important part of the Julius

Center’s research is also conducted in collaboration with research insti-

tutes and universities in many different countries. Several structural col-

laborations exist, including the European EPIC study which has been

continuous for many years and addresses an ongoing sequence of differ-

ent research questions and the GRACE project, a European Committee-

sponsored network aimed at improving diagnosis and treatment of

respiratory tract infections in primary care.

Other collaborations are more project-based. A recent survey revealed

over forty research projects that are currently ongoing in an internation-

al setting. Several staff members have international affiliations, Professor

Peeters is part time professor at the Imperial College London, and

Professor Moons, Dr Geerlings, Professor Grobbee and Professor Van

Delden also have international affiliations. Similarly, several renowned

international researchers have visiting appointments at the Julius Center.

In addition to the inspiring and productive contacts between staff mem-

bers and fellows with peers all over the world, the Center aims to estab-

lish more extensive long-term structural partnerships with strategically

selected high-quality Academic institutions. These include Imperial

College in London, Boston University and the George Institute for

International Health in Sydney. These and other contacts will play an

important role in the Julius Center’s ambition to stay at the forefront of

international health scientific research and disseminate knowledge to an

international audience of students and health professionals

IRAS

The Institute for Risk Assessment Sciences (IRAS) is an interfaculty

research institute within the Utrecht University faculties of Veterinary

Research 45


Medicine, Medicine and the faculty of Science. Both the director,

Professor Brunekreef, and the head of the division of environmental epi-

demiology, Professor Heederik have formal affiliations with the Julius

Center. The institute performs interdisciplinary research that concen-

trates on risk assessment of chemical, physical and biological agents on

man and the environment. It also educates and trains graduate and post-

graduate (PhD) students in the disciplines of toxicology, environmental

and occupational health and epidemiology. The research is performed in

three divisions: Environmental Epidemiology, Toxicology, and

Veterinary Public Health. Research within the Environmental

Epidemiology and Veterinary Public Health Divisions is determinant-

oriented epidemiological research which, in most cases, is conducted in

close collaboration with groups from UMC Utrecht (Julius Center,

Heart and Lung Institute, Wilhelmina Children’s Hospital). The IRAS

input to collaborative projects involves exposure assessment methodo-

logy and advanced exposure response modeling. Specific areas of

research are cancer and exposure to airborne particulate matter, polycy-

clic aromatic compounds, dioxin, organic solvents, allergens and

Microbial Associated Molecular Patterns (MAMPs). There is a particular

interest in exposure to infectious agents and in veterinary public health

issues including zoonoses and exposure to microbial agents through the

food chain.

UU Research Focus Area Epidemiology & the Utrecht Centre for

Infection Dynamics (UCID)

Based on faculty priority areas, Utrecht University has selected fifteen

thematic clusters of research. These focus areas consist of multidisci-

plinary clusters bringing together top-class research groups in each the-

matic field. One of these fifteen fields is Epidemiology, in which epide-

miological research groups collaborate. To quote part of the mission

statement ‘…In close interaction with medical and veterinary specialists

we hope to gain an improved understanding of the origin, diagnosis,

prognosis, treatment and prevention of diseases through research, dis-

semination and education. Our research concentrates on cardiovascular

diseases, cancer, allergy, and infectious diseases, the latter particularly

being relevant to both humans and animals.’ Concrete results from the

collaboration are the PhD program Epidemiology and the Utrecht

Centre for Infection Dynamics (UCID). The latter is a virtual center

that, in collaboration with the RIVM, focuses on interdisciplinary

research in infection disease dynamics.

Examples of international collaboration

Collaborations exist, among others, with the following institutions:

- Berman Center for Outcomes and Clinical Research, University of

Minnesota, Minneapolis, US Department of Clinical Epidemiology,

University of Pretoria, South Africa.

- Clinical Trial Services Unit and Department of General Practice,

University of Oxford, Oxford, UK.

- Departments of Epidemiology and Nutrition, Harvard School of

Public Health, Boston, USA.

- Department of Cancer Epidemiology, Imperial College, London, UK

- Department of Epidemiology, Karolinska Institute, Stockholm,

Sweden.

- Department of Epidemiology, UCSF, San Francisco, USA.

- Department of Food Science and Nutrition, University of Minnesota,

USA.

- Department of Health Evaluation Sciences, University of Virginia

Medical School, Charlottesville, Virginia, USA.

- Department of Neurology, University of Western Ontario, Ontario,

Canada.

Research 47


- Department of Public Health, Wake Forest University, Winston Salem,

USA.

- Departments of Nutrition and Cancer, Hormones and Nutrition,

International Agency for Research on Cancer, IARC, Lyon, France.

- Framingham Heart Study, NHLBI, Boston University Medical Center,

Boston, USA.

- George Institute for International Health, Sydney, Australia.

- Medical Research Council London, UK

- Medical Research Council, Dunn, Cambridge, United Kingdom.

- University of Indonesia, Jakarta, Indonesia

- University of Malaya Medical Center (UMMC), Kuala Lumpur,

Malaysia

- University of Tokai, Isehara, Japan

- Wallenberg Laboratory, Sahlgrenska Hospital, Gothenburg, Sweden.

Research Highlights

The year 2008 was very successful for research at the Julius Center. Our

scientific production set a new record in terms of the number of peer-

reviewed publications (more than 400) and PhD thesis defenses in

which a staff member of the Julius was involved as (co-)supervisor

(n=39). Diederick Grobbee and Yolanda van der Graaf ended up being

number 1 and 3, respectively, on the Utrecht University 2008 ‘PhD

Supervisor of the Year’ chart. Also, the quality and impact of our

research output was remarkable in 2008 and this is illustrated by the

large number of publications (a total of 10) in the highest-quality

general medical journals, i.e. the New England Journal of Medicine,

Lancet and JAMA. Several prestigious prizes were awarded to staff mem-

bers from our Center in 2008, including the Heineken award to

Professor Bert Brunekreef, the Catherijne Prize to Professor Diederick

Grobbee and the Elisabeth von Freyburg Medal to Dr Maroeska Rovers.

In addition, many research grants were obtained, including individual

grants, such as the Dekker Stipendium from the Netherlands Heart

Foundation that was awarded to Dr Joline Beulens.

Research 49

Education

‘Working on the GP of tomorrow’

(samenwerken aan de huisarts van morgen)

Rob Wolswijk,

Trainee General Practice Vocational Program

Education 53

Educational Organization

Education at the Julius Center is typically organized per discipline. Each

discipline has its own co-coordinator who fine-tunes the different teach-

ing programmes within that particular discipline. In July 2008, the

Biostatistics section joined the Julius Center. Biostatistics was previously

united under the Center for Biostatistics. This Center was responsible

for the education of biostatistics at the faculties of pharmaceutical

s ciences, biology and veterinary medicine. Now, the biostatisticians

operate from the Julius Center, regard this as their home institution and

are still responsible for the biostatistics courses in the different faculties.

The Julius Center participates in numerous educational programmes

covering a broad range of health sciences and primary care. The Center

actively participates in new educational developments such as the UMC

Utrecht’s ambitious undergraduate medicine programme (CRU), which

started in 1999 and was updated in 2006 which is based on interdisci-

plinary problem-oriented learning, and SUMMA, a new 4-year medical

grade program that started in 2004. The majority of educational pro-

grammes are provided in collaboration with other divisions within or

outside the University Medical Center Utrecht. The Center is no longer

responsible for the only Dutch graduate programme for nursing science.

Since august 2008, the University Medical Center Utrecht’s Division of

Education and Research has been in charge of the programme for nurs-

ing science. Among other things, the center is responsible for the special-

ist training of medical doctors as general practitioners in a three-year

vocational training programme. Notably, a new training programme for

a master’s degree in epidemiology was started in 2004, together with

other faculties of Utrecht University. In 2008, the master programme

extended the advanced elective courses and two core courses were com-

pletely revised. Education for the benefit of researchers at the Julius


Bachelor

Biostatistics

(Indication of year budget

€ 2,904,000)

Contribution courses in bachelor program’s:

Biology (years 1, 2 and 3)

Veterinary Medicine (year 1)

Pharmaceutical Sciences years 1, 2 and 3)

Medicine (CRU year 3)

Biomedical sciences (BMW, years 2 and 3)

Epidemiology


€ 640,000)

Architecture of Clinical Scientific Research (Architectuur van

Klinisch Wetenschappelijk onderzoek) (CRU year 3)

Elective course Clinical Trials (BMW)

Scientific electives (wetenschappelijke stages) (BMW + CRU)

General Practice


€ 1,130,000)

Orientation medicine (CRU year 1)

Patient care in the Netherlands

(CRU year 1)

Clinical reasoning (CRU year 1)

Public Health


€ 800,000)


Elective course Health & law (Gezondheidsrecht) (CRU)

Elective course Health care management (Zorgmanagement)

(CRU)

Elective course Diversity (Diversiteit) (CRU)

Elective course Forensic Medicine (Forensische geneeskunde)

(CRU)

Medical Humanities


€ 603,000)

Medical Humanities I (CRU year 3)

Medical Humanities II (CRU year 3)

Nutritional Science


€ 304,000)

Elective course Nutrition in Medicine

(Voeding in de geneeskunde) (CRU)

Nursing Science

(Indication year budget n.a.

discontinued in 2008)

Master

Post-Graduate/

Continuous Professional Education

Contribution courses in MSc programme’s:

Ecology of plant communities and landscapes

Veterinary medicine (year 5)

Pharmaceutical Sciences

SUMMA

Nursing Science

Linguistic Science

Epidemiology

Ten-day introductory course

Number of short (one or two-day) courses

Contribution courses: MSc Epidemiology

Postgraduate (Health Sciences)

MSc programme Epidemiology

(BMS, full two year programme)

START (CRU year 6 + SUMMA year 4)

Scientific electives (wetenschappelijke stages)

(CRU + SUMMA)

MSc programme Epidemiology Postgraduate

(Health Sciences, full 1.5 year programme.

Courses also offered separately)

Discipline Overstijgend Onderwijs

Clinical Epidemiology for Internists (NIV)

Practice of care; nursing apprenticeship

(SUMMA year 1)

Co-assistentschap huisartsgeneeskunde

(SUMMA year 3 + CRU year 5)

Off-ward (SUMMA year 3)

ASAS (SUMMA + CRU)

Scientific and practical electives (SUMMA + CRU)

General Practice

Vocational Training

Post-Academic Education for General Practi-

tioners (PAO-H)

Educational programme NHG Kaderopleiding

Diabetes

Medicine and Society

(Geneeskunde en Maatschappij) (CRU year 5)

START (CRU + SUMMA

Internship (co-schappen) (4 weeks), elective

practicals (6 weeks), BSAS (12 weeks)


(12 weeks) both national and international

Integrated Care master classes and symposia

Study visits to Kaiser Permanente USA and

Canada

Educational programme ‘Justitieel

Geneeskundigen’


MSc programme Nursing Science (Gezondhe-

idswetenschappen, full one year programme)

Reading and judgment scientific (nursing sci-

ence) research

Education 55

Bachelor

Biostatistics


€ 2,904,000)

Contribution courses in bachelor program’s:

Biology (years 1, 2 and 3)

Veterinary Medicine (year 1)

Pharmaceutical Sciences years 1, 2 and 3)

Medicine (CRU year 3)

Biomedical sciences (BMW, years 2 and 3)

Epidemiology


€ 640,000)

Architecture of Clinical Scientific Research (Architectuur van

Klinisch Wetenschappelijk onderzoek) (CRU year 3)

Elective course Clinical Trials (BMW)

Scientific electives (wetenschappelijke stages) (BMW + CRU)

General Practice


€ 1,130,000)


Patient care in the Netherlands

(CRU year 1)

Clinical reasoning (CRU year 1)

Public Health


€ 800,000)


Elective course Health & law (Gezondheidsrecht) (CRU)

Elective course Health care management (Zorgmanagement)

(CRU)

Elective course Diversity (Diversiteit) (CRU)

Elective course Forensic Medicine (Forensische geneeskunde)

(CRU)

Medical Humanities


€ 603,000)

Medical Humanities I (CRU year 3)

Medical Humanities II (CRU year 3)

Nutritional Science


€ 304,000)

Elective course Nutrition in Medicine

(Voeding in de geneeskunde) (CRU)

Nursing Science

(Indication year budget n.a.

discontinued in 2008)

Master

Post-Graduate/

Continuous Professional Education

Contribution courses in MSc programme’s:

Ecology of plant communities and landscapes

Veterinary medicine (year 5)

Pharmaceutical Sciences

SUMMA

Nursing Science

Linguistic Science

Epidemiology

Ten-day introductory course

Number of short (one or two-day) courses

Contribution courses: MSc Epidemiology

Postgraduate (Health Sciences)

MSc programme Epidemiology

(BMS, full two year programme)



(CRU + SUMMA)

MSc programme Epidemiology Postgraduate

(Health Sciences, full 1.5 year programme.

Courses also offered separately)

Discipline Overstijgend Onderwijs

Clinical Epidemiology for Internists (NIV)

Practice of care; nursing apprenticeship

(SUMMA year 1)

Co-assistentschap huisartsgeneeskunde

(SUMMA year 3 + CRU year 5)

Off-ward (SUMMA year 3)

ASAS (SUMMA + CRU)

Scientific and practical electives (SUMMA + CRU)

General Practice

Vocational Training

Post-Academic Education for General Practi-

tioners (PAO-H)

Educational programme NHG Kaderopleiding

Diabetes

Medicine and Society

(Geneeskunde en Maatschappij) (CRU year 5)

START (CRU + SUMMA

Internship (co-schappen) (4 weeks), elective

practicals (6 weeks), BSAS (12 weeks)


(12 weeks) both national and international

Integrated Care master classes and symposia

Study visits to Kaiser Permanente USA and

Canada

Educational programme ‘Justitieel

Geneeskundigen’


MSc programme Nursing Science (Gezondhe-

idswetenschappen, full one year programme)

Reading and judgment scientific (nursing sci-

ence) research


Center takes place by means of participation in recognized graduate

schools such as the Netherlands Institute for Health Sciences (NIHES)

(www.nihes.nl), Infection & Immunity (www.eijkmanschool.org),

Psychology and Health (http://pandh.fss.uu.nl), and ImagO (www.

imago.uu.nl). The number of educational programmes is growing each

year. The Center supports the training of lecturers and in 2008 one staff

member obtained a senior teaching qualification (SKO) and another

gained a basic teaching qualification (BKO). The table on page 54-55

summarizes the programmes (original names of the courses) that are

coordinated by staff-members from the Julius Center. A more detailed

description can be found in the specific chapters and on the website.

Education 57

General Practice

Introduction

The General Practice staff of the Julius Center participates in various

courses and ongoing educational programmes at several levels in the

medical curriculum (bachelor, master). Besides these activities, there is a

three year vocational training programme and is continuous medical

education provided.

The primary purpose of all of these courses is to teach students the prin-

ciples and methods of general practice, for the trainees in the vocational

training programme to become competent general practitioners and for

the general practitioner to keep his competencies on the optimal level.

Medical Bachelor and Master, CRU

Description

At the university medical school, traditionally a three year period of

acquisition of knowledge and skills is followed by three years of intern-

ships, where people gain their basic medical experience in teaching hos-

pitals and (for 6 weeks) in general practice. During the last decade the

period of practical experience in internships has been partially moved

forward to the 3rd year of the Bachelor. This step was motivated by evi-

dence that theoretical education, in combination with practical experi-

ence, allows students to construct their own knowledgebase more effi-

ciently and more effectively. It gives a student more opportunities for

learning within the context of his future work.

In short two trends are visible in undergraduate teaching, one is early

internships and the second is realizing a better link between undergrad-

uate and post graduate teaching to make the 3rd year of the Master more


of a transition year between undergraduate teaching and the specializa-

tion or postgraduate teaching.

Course information

In every class-year 300 students are taught. The department of general

practice is responsible for the introductory course for new medical stu-

dents (1st year). In the last two weeks of this 5-week course most stu-

dents gain experience in clinical practice during a nursing apprentice-

ship and a small number of them (24 students) are able to participate in

an observational apprenticeship in general practice.

All educational programmes are problem-oriented and several disci-

plines collaborate in each course.

General practice contributes and coordinates to the following courses:

Course

Coordination/

contribution

Number of

partici-

pants

% passed

exam

Evaluation

marks

Orientation in Medicine, first year Coordination 300 95% 6.9

Nursing/GP apprenticeship, first year Coordination 300 100% 7.3

Students following patients pro-

gramme, first year

Coordination 300 na 6.6

Clinical reasoning programme, first year Coordination 300 80% 6.5

Students following patients pro-

gramme, second year

Coordination 15 93% 7.7

Eye-diseases, second year Contribution 288 na na

Medicine and society, second year Contribution 288 na na

Metabolism, second year Contribution 290 na na

Infection and immunity, third year Contribution 290 na na

Acute medicine, third year Contribution 290 na na

GP Internship, second year (6 weeks) Coordination 288 99% 8.2

GP Practical electives, second year

(6 weeks)

Contribution 18 100% na

GP Internship, third year (12 weeks) Contribution 46 100% na

Education 59

GP Scientific electives, third year

(12 weeks)


GP Practical electives, third year

(6 weeks)


Medical Master, SUMMA

Description

In the first and the second year of the SUMMA masters programme all

students (40 students annually) are trained in clinical reasoning by GP

staff members. In addition, most students gain experience in clinical

practice during a nursing apprenticeship in their first year. Five students

per year will be offered the opportunity to participate in an observation-

al apprenticeship in general practice. In the third year all students have a

five week internship in general practice, while two or three students are

supervised annually in a longer internship of 12 weeks and in a scientific

elective in the 4th year.

Course

Coordination/

contribution

Number of

partici-

pants

% passed

exam

Evaluation

marks

Nursing apprenticeship, first year Coordination 40 100% 7.9

Clinical reasoning, first and second year Contribution 40 na na

GP Internship, third year (6 weeks) Coordination 36 100% 8.3

GP Internship, fourth year (12 weeks) Contribution 3 100% na

GP Scientific elective, fourth year

(12 weeks)


General Practice Vocational Training (Postgraduate)

Description

In the Netherlands general practice vocational training is offered by 8

Institutes for Postgraduate Training. One of them is the Julius Center

where each year 72 trainees start with the 3-year programme. In the


coming two years the number of trainees will grow to 84 trainees a year.

The three-year course consists of two years of training in general prac-

tice and one year in hospitals, health care institutes and nursing homes.

In order to serve the needs of the course, there is close cooperation with

213 general practitioners, 7 peripheral hospitals, 22 nursing homes and

18 regional institutes for outpatient mental health care. The trainees

attend the department of general practice for reflection and training one

day a week.

In close cooperation with the other university centers and the Dutch

College of General Practitioners several educational and ICT manage-

ment tools have been developed including the construction of a core

competency oriented curriculum. The main advantage of this coopera-

tion is the exchange of experience on a national level, allowing us to

learn from each other and become stimulated to improve our own

results. The cooperation in the Julius Centre is especially relevant to the

subject of EBM education.

We do recognize and certify previous postgraduate experience in teach-

ing hospitals. In half of the cases, this leads to a mean reduction of the

training period of 6 months.

Since 2006 the curriculum is competency oriented. The seven compe-

tencies are: medical expertise, doctor patient communication, collabora-

tion, management, social accountability, science and education and pro-

fessionalism. In such a competency oriented curriculum you need an

adequate assessment programme. The trainee then adjusts his or her

individual learning and development plan on the basis of an assessment.

An extensive assessment programme has been developed in Utrecht and

also in the other departments in the Netherlands. There is a Go/No Go

decision taken at the end of the first year.

Education 61

Course information

Each of the three training years has different characteristics. In the first

year the emphasis is on obtaining and sharpening skills in general prac-

tice. In the second year, particular attention is paid to the cooperation

between the GP and specialists and training in special skills by doing

internships in hospitals and Regional Institutes for Outpatient Mental

Health Care and Nursing Homes. In the third-year, the acquisition and

integration of in-depth knowledge takes center stage. Every effort is

made to increase the expertise and quality of future GPs.

Networks of general practices appear now and then, with franchising

formulas and central management.

They tend to organize their own facilitating services in order for groups

of GP practices to gain more efficiency and more competitive power.

Within general practice, one can perceive a trend of differentiation

between GPs and GP groups. This means that new tasks are taken up by

reasonably specialized GP’s within a group and this then creates oppor-

tunities to distribute tasks between the GPs. By doing so, one can a high-

er level of care as a result of cooperation.

That is why there are possibilities for differentiation in the new curricu-

lum.

Course titles

First year: four days of general practice training in medical practice and

a day-release course for one day, with different topics.

Second year: internship in emergency department general hospital,

mental health and nursing home.

Third year: four days of general practice training in medical practice,

differentiation on management/ education/ science/ special interest like

diabetes, asthma, COPD, cardiovascular risk management.


Output 2008

Number of students

In just a few years, capacity has been increased to 216 trainees in 2008.

- Number of students who started their GP training in 2008: 74

- Number of students who finished their GP training in 2008: 70

Advanced Training in General Practice

(Continuing professional education)

Description

This involves post-academic training for general practitioners (Post

Academisch Onderwijs voor Huisartsen, PAOH-Utrecht). The focus is

on information for GPs that is up-to-date, evidence based and relevant

to general practice. The courses are interactive and use an interactive

voting system. All speakers are experts on their topic.

Also the ‘NHG kaderopleiding Diabetes’ is coordinated by staff members

of the Julius Center.

Course information PAOH

In 2008 the Julius Center organized 9 days (each of 6 accreditation

points) and 2 afternoons (PAOH EXTRA, 3 accreditation points) for

GPs in the Netherlands.

Course titles (in Dutch) Course Course dates Number of participants

Diagnostiek Feb 1 191

Onbegrepen klachten Apr 4 170

Neus en longen Apr 24 69

Hart- en vaatziekten May 23 150

Reizigersgeneeskunde Jun 12 146

Education 63

Geriatrie Sep 19 145

Zorg rondom het levenseinde Oct 3 171

11e Diabetesdag Nov 6 96

Neurologie Dec 19 130

Huisarts van nu (EXTRA) Mar 6 60

De basis van de standaarden (EXTRA) Mar 6 62

Output 2008

80-200 GPs attended each course (with a total of around 1200 GPs)

Evaluation

PAOH courses consistently receive good evaluations.


Epidemiology

Medical Bachelor

AKWO (architectuur van klinisch wetenschappelijk onderzoek)

- Architecture of clinical scientific research

Brief course description

In modern medicine, physicians ask themselves continuously to what

extent their medical decisions (diagnostic, therapeutic, prediction of

prognosis) are based on solid scientific evidence. This 6-week full time

course will equip medical students with the basic knowledge and skills

of clinical epidemiology.

In order to be able to value and interpret scientific reports, students will

need to acquire their own research experience. During this course stu-

dents will learn how scientific knowledge is generated. We give the stu-

dents a taste of the various aspects of clinical scientific research by simu-

lating the entire process of a scientific research project.

They will learn how to define a research question, select the appropriate

study design to answer this question, prepare a research protocol, collect

data, analyze it, interpret results, report and present the findings. At the

end of this course students will be able to differentiate between the dif-

ferent study designs, methods and analytic techniques of etiological,

diagnostic, prognostic and therapeutic research.

Students work in small teaching groups, on practical assignments, and

in workshops and participate in ‘meet the expert’ meetings.

This course runs 12 times a year for groups of 25 students. Each time the

course is constructed around a(nother) clinical problem, for example

chest pain or neurological deficits and each year approximately six clini-

cal problems will be discussed. The selection of clinical problems is

based on the problem’s frequency of occurrence and the clinical and

Education 65

research expertise of the supervisors. Therefore, although this is not the

main objective of the course, students will improve their incidental

knowledge etiology, diagnosis, prognosis and therapy of the clinical

problem chosen.

Course Course dates Number of participants % passed exam Evaluation marks

AKWO 12 courses between

Aug 2007– Jul 2008

263 97% 7.0

Medical Master of Science Degree

Evidence based medicine

START module and Return Days

(in Dutch ‘Startblok en Terugkomdagen’)

Brief description of course content

In modern medicine, physicians ask themselves continuously to what

extent their medical decisions (diagnostic, therapeutic, prediction of

prognosis) are based on solid scientific evidence. This 6-week part time

course during the final 6th year of medical school will equip medical stu-

dents with the principles of evidence based medicine and applied

knowledge and skills of medical evidence management. This course

builds on the skills and knowledge acquired during the AKWO course

during the 3rd year of medical school.

In order to be able to apply best available evidence in patient care, stu-

dents will need to acquire their own experience with medical evidence

management. During this course students will learn how to write a case

report: a 1200 word comprehensive summary of best available evidence

on questions concerning the management of a particular patient. These

focus on a foreground question, i.e. an applied problem of diagnostic,

AsiaLink Clinical Epidemiology & Evidence Based Medicine

This EU funded project, initiated by the Julius Center, is a collaboration

between the University Hospital Cipto Mangunkusomo (Jakarta Indonesia),

the University of Malaya (Kuala Lumpur Malaysia), the University of Oxford

(UK) and the University Medical Centre Utrecht. The aim is to establish a

platform for a durable improvement and collaboration in clinical epidemio-

logical teaching and research in Indonesia and Malaysia. Specific actions

include a teaching mission, PhD fellowships and the set-up of a Clinical

Epidemiology Support Unit in Jakarta and Kuala Lumpur. The project start-

ed in November 2007 and will run until October 2010.

Teaching mission, post-graduate

During the first year of the programme, four basic and four advanced post-

graduate courses have been offered, in which a total of 380 medical doc-

tors / clinical researchers / health policy makers participated. For an over-

view of the courses see the chapter on education.

Teaching mission, under-graduate

After several rounds of meetings between educational specialists, university

administration and professors of the Julius Center and the two Asian insti-

tutions, we have now developed an undergraduate module in clinical epi-

demiology and evidence based medicine, tailored to the Asian context. The

module has been adapted from the third year module on clinical epidemi-

ology and fourth year module on Evidence-Based Medicine of the

University Medical Center Utrecht. In both Asian institutions, the module

has been embedded in the medical curriculum. In Jakarta, some 200 fourth

year medical students will start a five week, full time module in May 2009,


and in Kuala Lumpur, around 200 third year medical students will start a 13

week, part-time module in August 2009.

PhD fellowships

In early 2008, we selected a first group of PhD fellows (2 from Kuala

Lumpur and 2 from Jakarta). This fellowship includes training in Clinical

Epidemiology in Utrecht/Oxford, followed by a PhD research project, in

close collaboration and under the mentorship of Julius Center professors.

In September 2008, three medical doctors from Jakarta and Kuala Lumpur

started the one year postgraduate MSc training programme in Clinical

Epidemiology at the Julius Center and one fellow started her PhD training

in Oxford, under the supervision of Prof Glasziou.

In October and December 2008, we held new selection rounds and we have

now selected an additional 7 PhD fellows (4 from Indonesia, 3 from Kuala

Lumpur) who will start their MSc Clinical Epidemiology at the Julius Center

in September 2009.

Set up of Clinical Epidemiology Support Unit at RS Cipto Mangunkusumo

and University Malaya.

The Julius Centre University Malaya (JCUM), Centre for Clinical

Epidemiology and Evidence-Based Medicine, has now officially been estab-

lished at the University of Malaya. At University of Malaya and RS Cipto

Mangunkusumo, office space has been made available to host the CE &

EBM Coordination Unit and in both institutions a full time project officer

has been employed.

Project management

Project coordination, monitoring and evaluation:

The Steering committee consists of Prof Yolanda van der Graaf, Prof Arno

Hoes, Prof Diederick Grobbee (all University Medical Center Utrecht), Prof

Education 67

Awang Bulgiba (University Malaya Kuala Lumpur), Prof Sudigdo

Sastroasmoro (RS Cipto Mangunkusumo Jakarta), Prof Paul Glasziou

(University of Oxford), Dr Helena Verkooijen (University Medical Center

Utrecht, based in Singapore).

During several meetings, attended by the members of the steering commit-

tee (April 08 and Oct 08, in Kuala Lumpur and Jakarta), the roles, responsi-

bilities, rights and mutual obligations of the different partners were speci-

fied in a Memoranda of Agreement between the four partners.

Stakeholder communication is taking place through our website

(www.asialink-ce.org), biannual newsletters, press conferences during the

official launches of the project in both Kuala Lumpur (19th Nov 2007) and

Jakarta (17th April 2008) and publicity talks at conferences, embassies, other

tertiary education institutions in the region.


Education 69

prognostic and therapeutic patient management rather than on a theo-

retical or conceptual scientific background problem.

For this we teach them to adequately translate the problem into a well

phrased research question, efficiently retrieve and select the best avail-

able evidence and tabulate and translate it in terms of clinical patient

management.

We use small teaching groups, with practical assignments, workshops

and meet the expert meetings.

During their subsequent 24 week internship at the clinical ward, stu-

dents are given an assignment to write 3 case reports per couple. Each

student reviews and grades 6 case reports of other students.


EBM module

START

6 courses between

Aug 2007 – Jul 2008

270 100% 7.6

SUMMA Scientific Education 2

(in Dutch: ‘Wetenschappelijke Vorming-2’)

During this course, students of the Selective Utrecht Medical Master’s

(SUMMA) Programme will learn about the theory of risk and the epide-

miologic design of diagnostic, prognostic and experimental research in

plenary lectures and moderated small student groups.

At the end of this course students will be able to differentiate between

the different study designs, methods and analytical techniques of etio-

logical, diagnostic, prognostic and therapeutic research, and have

learned how to value and interpret scientific reports, as well as how to

define a research question, select the appropriate study design to answer

this question and prepare a research protocol.

This course runs once a year for groups of 40 students.



SUMMA May 2007 40 100% 6.7

Biomedical Master of Sciences Degree

Epidemiology Research Master’s Programme

Brief description of programme content

The Utrecht University Graduate School of Life Sciences offers two

Epidemiology Research Master’s programmes which are organized by

research groups at UMC Utrecht (Julius Center) and Utrecht University

(IRAS, Veterinary Epidemiology, and Pharmaco-epidemiology):

- ‘Epidemiology’, a 2-year programme within Biomedical Sciences,

aimed at students holding a Bachelor of Science degree in Biomedical

Sciences, (Veterinary) Medicine or Pharmaceutical Sciences.

- ‘Epidemiology Postgraduate, an 1.5-year postgraduate programme

within Health Sciences, aimed at professionals holding a Master’s of

Science degree in Life Sciences or (Bio-)Medical Sciences, Medicine

(MD), Pharmaceutical Sciences (PharmD), or Veterinarian Medicine

(DVM).

The two main components of the programmes are:

- comprehensive theoretical education in the principles and methods of

epidemiological research;

- a practical research project in which the theory can be applied;

rounded off with the writing of a scientific paper and an oral

presentation.

Students are provided with extensive knowledge and practical skills in

patient-oriented research, including design and quantitative analysis.

The knowledge and skills gained form a solid basis for health research

Education 71

and disease control programmes, including application in developing

countries.

The programmes provide specializations in Clinical Epidemiology,

Epidemiology of Infectious Diseases, Pharmaco-epidemiology,

Occupational and Environmental Epidemiology, or Veterinary

Epidemiology.

More information: www.msc-epidemiology.nl.

Course Course dates

Number of

participants

% passed

exam

Evaluation

marks

Introduction to Epidemiology 3-14 Sep 2007 50 100% 7.6

Study Design 24 Sep – 12 Oct

2007

43 91% 7.5

Clinical Epidemiology 12 - 30 Nov 2007 34 100% 6.8

Presentation and writing of

research proposal

4 – 8 Feb 2008 29 100% 7.4

Advanced Diagnostic Research 3 – 7 Mar 2008 42 100% 7.3

Prognostic Research 31 Mar – 4 Apr

2008

40 100% 7.5

Clinical Trials and Drug Risk

Assessment

21 – 25 Apr 2008 42 98% 6.8

Basics of advanced mathematical

modeling of infectious diseases

26 - 30 May 2008 18 100% 7.4

Advanced mathematical modeling

of infectious diseases

2 – 6 Jun 2008 14 79% 7.1

Nutritional Epidemiology 24 – 28 Nov 2008 29 96% 7.8

Continuing Professional Education

Clinical Epidemiology (NIV)


This 1-day course on the principles of Clinical Epidemiology and

Evidence Based Medicine for members of the Dutch Society of Internal


Medicine (NIV), in particular for residents and registrars, includes ple-

nary lectures on methods of applied research and evidence based medi-

cine and small moderated student groups. At the end of this course par-

ticipants are familiar with the principles of epidemiological study design

for diagnostic, prognostic and intervention research and are able to criti-

cally appraise clinical medical research papers and clinical guidelines.

Evidence Based Medicine

(Discipline Overstijgend Onderwijs)


This 2-day course on the principles of Evidence Based Medicine for

clerks and residents at UMC Utrecht and collaborating teaching hospi-

tals, includes plenary lectures on methods of applied research and evi-

dence based medicine, small moderated student groups and additional

lectures provided by external speakers.

At the end of this course, participants are familiar with the principles of

epidemiological study design for etiologic, diagnostic, prognostic and

intervention research, are able to coherently formulate a clinical ques-

tion, search databases, critically appraise clinical research papers, clearly

summarize and present available evidence and critically consume clini-

cal guidelines.

Course Course dates

Number of

participants

% passed

exam

Evaluation

marks

EBM DOO 24 Jan - 7 Feb 2008 40 100% 7.8

NIV One day clinical epidemiology course for

internal physicians in training. Course

given on 17 Apr 2008 and on 9 Oct 2008

147 in Apr

135 in Oct

100% 6.9 in Apr

6.8 in Oct

Education 73

AsiaLink Clinical Epidemiology & Evidence Based Medicine

This EU funded project, initiated by the Julius Center, is a collaboration

between the University Hospital Cipto Mangunkusomo (Jakarta

Indonesia), the University of Malaya (Kuala Lumpur Malaysia), the

University of Oxford (UK) and the University Medical Center Utrecht.

The aim is to establish a platform for a durable improvement and col-

laboration in clinical epidemiological teaching and research in Indonesia

and Malaysia. Specific actions include a teaching mission, PhD fellow-

ships and the set-up of a Clinical Epidemiology Support Unit in Jakarta

and Kuala Lumpur. The project started in November 2007 and will run

until October 2010. For more information see the ‘yellow pages’ else-

where in the year report. Below you will find the overview of courses

taught by Julius Center staff.

Course Date Location Level Faculty

Number of

participants

Evidence Based Medicine Apr 2008 University Malaya Basic Oxford 24

Clinical Epidemiology Apr 2008 RSCM Jakarta Basic Utrecht 58

Clinical Trials Apr 2008 RSCM Jakarta Advanced Utrecht 61

Evidence Based Medicine Apr 2008 RSCM Jakarta Basic Utrecht 24

Basic Epidemiology Nov 2008 RSCM Jakarta Basic Utrecht 37

Prognostic Research Dec 2008 University Malaya Advanced Utrecht 60

Clinical Trials Dec 2008 University Malaya Advanced Utrecht 55

Diagnostic Research Dec 2008 RSCM Jakarta Advanced Utrecht 61


Public Health

The educational programme of Public Health defines the main focus of

the principles and methods of healthcare research, structure, quality,

finance and functioning of healthcare systems, with a focus on Social

Medicine and Public Health interventions.

Medical bachelor

In the first year of the bachelor phase, the course ‘Orientation to Medi-

cine’ (‘Orientatie Geneeskunde’) is offered. In this course, the main out-

lines of the organization of healthcare are the focus point. An internship

in a nursing home or a care institution of a different kind is part of this

course. Last year the average result of the evaluation by students was 7.

In the second year 4 optional courses of five weeks each are offered,

namely:

- ‘Care Management’ (‘Zorgmanagement’): The main objectives of this

course are the improvement of competence in the area of knowledge of

care management, co-operating within a multidisciplinary context and

communication with different kinds of professionals.

- ‘Law and Medicine’ (‘Gezondheidsrecht’): This course is centered

around the legal and regulatory framework of the Dutch health care

system, with a focus on the professional competence of doctors.

- ‘Diversity in prevention, illness and care’ (‘Diversiteit in preventie,

ziekte en zorg’): This course is set up to create and stimulate the

awareness of the presence and influence of diversity in the medical

profession.

- ‘Forensic Medicine’ (‘Forensische geneeskunde’): This course was

started for the first time and was a great success. A broad definition of

forensic medicine is used. It deals with aspects of legal and regulatory

Education 75

frameworks, forensic research, cooperation with the police and

identification experts in combination with medical expertise. The

excursions to forensic pathology, a prison, police forensic research,

military forensics and identification teams and an asylum center were

impressive.

Course Evaluation marks

Care Management’ (‘Zorgmanagement’) 8.0

Law and Medicine (‘Gezondheidsrecht’) 8.1

Diversity in prevention, illness and care’ (‘Diversiteit in preventie,

ziekte en zorg’)

n.a

Forensic Medicine’ (‘Forensische geneeskunde’) 7.9

Medical master

In year 5 the course ‘Medicine and Society’ is offered. Matters that are

being discussed within this course include aspects of health and health-

care and the ‘grey area’ between curative forces and society. Obligatory

internships in social medicine for a period of four weeks are connected

to this course.

In year 5 the course ‘TLO’ is also offered. In this course, themes in

patient safety are studied. Last year’s result is lower than expected. A

whole new programme on patient safety has been developed. Important

input was given by the staff bureau of the UMC Utrecht and their

patient safety department.

Year 6 focuses on the decision making processes in healthcare in emer-

gency situations and the organization, quality and finance of healthcare.

Examples of new providers of care in the mental health sector and the

introduction of new evidence based interventions in mental health dis-

ease management programmes are dealt with.


Optional internships of six weeks are part of the possibilities in the 4th,

5th and 6th year. In year 6 it is possible to do a BSAS, a scientific intern-

ship or an educational internship within the division of Public Health. It

is possible to do these internships and optional internships abroad.

All of the excellent internships were possible due to effective cooperation

with more than 100 affiliation partners within the public health sector.

Postgraduate / Continuing Professional Education

The post graduate education division provides additional and refresher

courses like symposia and conferences for graduated doctors. All of the

courses are accredited.

In cooperation with many foreign and non-foreign guest teachers, the

Public health division provides additional courses for professionals in

healthcare, set up in the form of conferences, courses, workshops and

study trips.

For more information visit the Julius Center’s webpage

www. juliuscenter.nl or for an overview on the different activities go to

www.integratedcare.nl, via ‘nascholing’.

Education 77

Biostatistics

The biostatistics group is responsible for most of the statistical courses

taught in the faculty of Medicine and the faculty of Science’s depart-

ments of Biology and Pharmaceutical Sciences.

Bachelor and Master’s Degree

The amount of statistics education is quite diverse in the various facul-

ties:

In Biology a compulsory 7.5 ECTS course covers descriptive statistics,

theory of testing and estimation, various T-tests, Chi-square test, corre-

lation and regression and one-way ANOVA. It is followed by an elective

7.5 ECTS course, which includes various other kinds of ANOVA, multi-

variate techniques, logistic regression, survival analysis and methods for

dependent data.

In contrast, in Medicine (CRU2006) our contribution is restricted to

three afternoons in the 6-week AKWO course, where statistics is not

taught as an independent discipline, but more as part of achieving the

goal of that course, i.e. simulation of the process of a scientific research

project.

The amount of statistics taught in the bachelor programmes of

Biomedical Sciences, Health Sciences and Pharmaceutical Sciences lies

between these two extremes.

In almost all of our courses the theoretical knowledge gained in lectures

is reinforced by practical and computer lab sessions, using the statistical

programmes SPSS and occasionally R. This should enable students to do

their own analyses, although in practice we see quite a lot of them again,

when they do their own research.


Postgraduate and Continuing Professional Education

Lastly we also provide some extra-curricular courses for researchers

(mainly) from the biomedical faculties. This includes a 2-week course

(Introductory Biostatistics for Researchers) given 2-3 times a year, in

which the latent statistical knowledge of researchers is refreshed and

some 1, 2 or 3 day courses on advanced subjects.

In the table a partial list of the major courses is provided.

Course Faculty /programme

Course

dates

Number

of partic-

ipants

%

passed

exam

Evalua-

tion

marks

Applied Biostatistics 1,

BSc second year

Science / Biology Nov

2007-

Feb 2008

170 73 % 5.7

Applied Biostatistics 2,

BSc third year

Science / Biology Sep-

Nov 2008

20 n.a. n.a.

Fa107, BSc first year Science / Pharm. Sc. Jun 2008 220 n.a. n.a.

Population, BSc

second year

Medicine / Biomedical Sc. Feb-Apr

2008

116 n.a. 5.0

Clinical trials, BSc third

year

Medicine / Biomedical Sc. Nov- Dec

2008

9 100 % 7.6

Statistics 1, Premaster

first year

Medicine / Health Sc. Sep 2008

- Jan

2009

81 81% 7.6

Statistics 2, Premaster

first year

Medicine / Health Sc. Feb-Jun

2008

56 93% 7.2

Methods & Statistics,

MSc first year

Medicine / Nursing Sc. Jan-Feb

2008

47 93% 7.7

AKWO, BSc third year Medicine / CRU2006 12

courses

Jul 2007 -

Jun 2008

263 97% 7.0

Introduction to Statis-

tics, MSc first year

Medicine / Biomedical Sc. /

Epidemiology

Sep 2008 45 n.a. n.a.

Education 79

Classical methods, MSc

first year


Epidemiology

Oct –

Nov 2008

44 93% 7.7

Modern methods, MSc

first year


Epidemiology

Jan 2008 37 92% 7.4

Introductory

Biostatistics for

Researchers

Extracurricular Apr, Jun

& Oct

2008

71 n.a. 7.8


Medical Humanities

Overview

Medical humanities is a term which we use for an interdisciplinary field

in which the humanities, sociology and arts come together. The humani-

ties are medical ethics, health law, history of medicine and philosophy of

medicine. Sociology is medical anthropology and medical sociology and

with arts we mean literature, theatre and movies.

The aim of this course is to help the student become a better physician:

- By providing insight into the human condition, complementary to his

or her biomedical knowledge

- By providing a better understanding of the responsibilities and duties

physicians have to their patients and society

- By showing that the art of medicine is performed within a cultural and

societal context which is characterized by diversity and by showing that

this context also shapes the experience of being ill and the way

medicine is performed

- By further developing the student’s competence for observing,

analyzing, empathy and self-reflection.

Bachelor

In the third year of the curriculum CRU2006 two courses of four weeks

each will be devoted to Medical Humanities. All students will have to

take both courses. Evaluations cannot currently be given as this course

has only recently started.

Course Course dates

Number of

participants % passed exam

Evaluation

marks

Medical Humanities I Start Sep08 312 Not yet available Not yet available

Medical Humanities II Start Sep08 312 Not yet available Not yet available

Education 81

Master’s Degree

In the master’s phase of CRU2006 no integrated courses in medical

humanities are given. Nonetheless, some of the disciplines of medical

humanities, especially health law and medical ethics will contribute to

courses, e.g. the starting course in the sixth year and in the honors pro-

gramme.


Contribution to the Clinical Epidemiology course in the postgraduate

Epidemiology master.


Nursing Science

Overview

In 2000, a Dutch Master of Science degree for the Health Sciences pro-

gramme was established at Utrecht University (UU). Nursing Science

was the first major field of study to be offered within the Health Sciences

programme. Physiotherapy Science was added as a second major field of

study in 2002 and Speech Therapy Science as the third field in 2003.

However, a new curriculum for the Health Sciences programme was

necessary in order to comply with the European regulations for universi-

ty education and to conform with the international Bachelor-Master

structure in higher education. This resulted in the development of a two

year part-time master programme (60 ects) for graduates of a BSc-

university degree programme or a premaster programme (see Bachelor).

The MSc master Nursing Science programme started in September 2005.

In July 2006, accreditation of the master programme was given by the

External Accreditation Committee (EAC) - a committee appointed by

the Ministry of Education and responsible for accrediting all university

programmes. The accreditation is valid until July 2012.

The Department of Nursing Science within the Julius Center for Health

Sciences and Primary Care is responsible for the development and coor-

dination of the Nursing Science field of study.

Bachelor

Description

At the moment the Utrecht University does not offer a Health Sciences

bachelor programme. Instead, a one year part-time pre-master pro-

gramme (30 ects) was developed for graduates of a bachelor degree pro-

gramme in professional education who want to continue their education

at a university master level.

Education 83

Programme information

Course Course dates EC

Number

of partici-

pants

%

passed

exam

Evalua-

tion

marks

Premaster Nursing Science Sep 2007 – Sep 2008 30

Project and Academic Skills Sep 2007 – Sep 2008 7.5 57 80 7.8

Philosophy, Science and Ethics Sep 2007 – Sep 2008 7.5 57 80 7.7

Research Methods Sep 2007 – Sep 2008 7.5 57 80 7.8

Statistics Sep 2007 – Sep 2008 7.5 57 80 7.6

Master

Description

The MSc Nursing Science programme is a two year part time academic

master’s course. Students are educated and trained in four roles: aca-

demic professional, researcher, innovation and information manager. As

a consequence the student is able to bridge the world of science and

nursing practice, and contribute to the development and scientific foun-

dation of nursing.

MSc Programme information

Course

Course

dates EC

Number of

participants

%

passed

exam

Evaluation

marks

Master Nursing Science 09/07–09/08 60

Nursing innovation theory and man-

agement

09/07–10/07 6.5 56 98 7.8

Innovation development and imple-

mentation

11/07–12/07 6.5 56 98 7.7

Research Methods & Statistics 01/08–02/08 2 56 100 7.7

Systematic Literature Review 01/08–03/08 7.5 60 85 7.5

Science and Nursing Practice 04/08–07/08 6.5 60 90 7.6

Elective course 09/07–12/08 6 60 100 n.a.


Master’s thesis: proposal and prepara-

tion

09/07–12/08 8 65 89 7.9

Master’s thesis: conduct and reporting 01/08–07/08 15 65 89 7.9

Portfolio 09/07–09/08 2 65 100 n.a.

For more detailed information (in Dutch) concerning the MSc pro-

gramme, have a look at Nursing Science’s website:

www.umcutrecht.nl/verplegingswetenschap


Description

In collaboration with the Education Center of the University Medical

Center Utrecht an annual 5-day course is offered for senior nurses about

reading and critically appraising scientific research (in nursing). The

content of the course is focused on scientific methodological concepts,

finding (by searching in scientific databases as PubMed) reading and

appraising quantitative and qualitative research and, finally, implement-

ing the scientific results in practice.

Course

Course

dates

Number of

participants

% passed

exam

Evaluation

marks

Reading and critical appraisal of scientific

research (in nursing)

21 100 7.5

Education 85

Nutritional Science

There are many misconceptions about the effect of nutrition on health.

Most consumers, patients and doctors are uncertain whether a prudent

diet can prevent diseases and whether clinical nutrition can help cure

disease. The Division of Nutritional Sciences strives to enhance the pro-

fessional competences and the understanding of nutritional problems,

depletion and metabolic needs in relation to disease. An important tar-

get group is the medical students. The Nutrition and Medicine

(‘Voeding in de Geneeskunde’) facultative courses take a collaborative

and interdisciplinary approach to nutritional problems in the clinical

setting.

Bachelor

Description

GNBA221806 – facultative course ‘Voeding in de Geneeskunde’ is a

5-week course for 2nd year bachelors. Learning objectives for the course

are adapted from the ‘Nutrition Curriculum Guide for Training

Physicians Curriculum from the Nutrition Academic Award Programme’

(Pearson TA, Stone EJ, Grundy SM, McBride PE, Van Horn L, Tobin BW;

NAA Collaborative Group. Translation of nutritional sciences into medi-

cal education: the Nutrition Academic Award Programme. Am J Clin

Nutr. 2001 Aug;74(2):164-70.)

Topics include:

- Appraising nutritional information

- Nutritional recommendations for healthy individuals

- Nutritional assessment and nutritional management in disease

- Changing nutritional behavior

- Nutritional Science


GNK0708 3 – facultative course ‘Voeding in de Geneeskunde’ is a 4-week

course for 3rd year bachelors. The course consists of (guest) lectures and

group work.

Topics include:

- Methodology: how to read scientific papers about nutrition and health

- Practice: how to assess nutritional status (malnutrition)

- Prevention of chronic diseases

- Therapeutic diets

- Nutritional supplements and functional foods

- Management of treatment side effects

- Management of specialized feeding regimens like tube feedings

- The effect of life style modification

Course

Course

dates

Number of

participants

%

passed

exam

Evaluation

marks

‘Voeding in de Geneeskunde’ -

GNBA221806, year 2 (elective)

Jun 2008 18 100 7.0

‘Voeding in de Geneeskunde’- GNK0708 3 Mar 2008 24 100 6.2

Master’s Degree

Not applicable


Not applicable

Education 87

International activities in Education

In education several international activities take place. These range from

inviting international guest lectures and hosting international students,

to organizing educational activities abroad.

Several of the Julius Center’s educational activities are in English and

attract international students, such as the MSc programme in

Epidemiology or the courses that are organized in the EU funded

Interact programme. In postgraduate education, such as the master

classes and congresses organized by the Public Health discipline or the

capita selecta of the MSc programme in Epidemiology, international

guest lecturers are frequently invited to contribute. As well as hosting in

Utrecht, both students and staff also go abroad to teach or be educated.

E.g. students are given the possibility of carrying out an internship

abroad, under the guidance of Julius Staff, with research groups with

whom collaborations exists. The GP vocational training offers an elec-

tive course for medical students on ‘Primary Healthcare’ in Tanzania and

a module on travelers’ advice and imported diseases to GP trainees also

in Tanzania.

Structural educational collaboration still exists with some counterparts.

In 2008 the Julius Center also taught various clinical epidemiology

courses abroad. These countries include Malaysia, Indonesia, Japan,

Canada and the US. The most important international educational

project is currently the European Committee funded project: ‘The Asia-

Europe Clinical Epidemiology and Evidence Based Medicine pro-

gramme’. The Julius Center, Centre for Evidence based medicine Oxford,

the Malaysian Ministry of Health and the University of Malaya Medical

Center (UMMC) in Kuala Lumpur, Malaysia are nurturing a growing

collaboration. (See also ‘Epidemiology, AsiaLink’ in this chapter). The


collaboration is based on short, intensive courses on clinical epidemiolo-

gy and evidence-based medicine, delivered by the Julius faculty in col-

laboration with local staff in Kuala Lumpur and Jakarta, the implemen-

tation of an undergraduate module on clinical epidemiology and evi-

dence based medicine in the curriculum of the faculties of Medicine in

both countries and the training of PhD students in clinical epidemiolo-

gy from both countries in the Netherlands. These PhD fellowships will

be supervised by the Julius staff and imbedded into the research lines of

both the UMC Utrecht and the UMMC. During the fellowship, candi-

dates will follow part of their education in the Netherlands, notably in

the Epidemiology prestige master’s programme. Depending on the sub-

ject, research will be carried out at the Julius Center or in their home

country.

The Asia-link project aims to cover three domains: a) Collaborative

research for clinical trials and cohort studies, b) Development and cre-

ation of a regional research infrastructure, c) Expansion of educational

programmes that also focus on the South Asian region.

In order to foster high quality research, a robust research-support

section is needed in both hospitals in which project managers, research

nurses, data managers, computer experts, trial monitors and administra-

tive personnel are based. In cooperation with local staff, the Julius

Center will continue to broaden the programme of short courses on

methods of clinical research. These courses are targeted at medical doc-

tors and clinical investigators in the Southeast Asian region. Eventually,

these courses will be largely conducted by local staff.

The courses in Japan are part of the MSc programme and are part of an

existing collaboration with various Japanese ‘Top’ Universities (Tokai

University, Tokyo University, Keio University, Kitasato University and

The National Cancer Institute). Prof K. Moons has a visiting professor-

Education 89

ship with Tokai and Kitasato University, organizer of these courses. The

courses include a 5-day course in the fall on ‘the principles of clinical

research’, which is followed by a spring course on ‘advanced clinical epi-

demiologic research’. Prof Moons also provides - as a visiting professor -

a one week course at McGill University, Montreal, Canada, on Advanced

Diagnostic Research, and a one week course at VanderBilt University,

Tennessee, US, on ‘advanced clinical research’.

In 2008 the MSc programme signed an intentional agreement with

Mainz University to collaborate in master education in epidemiology by

exchange of both students and staff.

Education 91

Patient care

‘The opportunity to put theory into practice means

being challenged’

Simone Kessel, Health Sciences Student

Patient Care 93

Nutritional Sciences and Dietetics

The department of Nutritional Sciences and Dietetics consists of two

groups: Nutritional Sciences and Dietetics. Education, research and

quality care consultancy are the core activities of Nutritional Sciences.

Patient care and improving patient care are the core activities of the

Dietetics section.

Nutritional Sciences

Nutritional Sciences aims to improve integration of evidence based

nutritional interventions in medicine. This is achieved by:

- Providing support to health care professionals (dieticians, medical

staff) in the process of developing and implementing evidence-based

nutritional policies and guidelines for several groups of patients.

- Performing (clinical) research on the relation between nutrition and

health (biomedical) and determinants of dietary behavior (social and

behavioral science).

- Providing education to both health care professionals and (para)-

medical students (both HBO and WO).

The department of nutritional sciences works in close collaboration

with the departments of Dietetics and Clinical Epidemiology.

Continuing education for medical and paramedical professionals was

provided by contributions to professional journals and lectures at

national congresses. The department participated in an advisory com-

mittee of the Dutch Health Council on the subject of ‘making healthy

choices, the easiest choices’. The department of dietetics was supported

in evidence-based dietetics (e.g. consultancy function, quality care

projects, journal clubs).


For research purposes an update has been made to a food-frequency

questionnaire and efforts have been made to make this questionnaire

available online. After the completion of this project it will be easier to

apply dietary assessment in a research setting. In addition, the depart-

ment supported several applied research projects from the department

of dietetics (see below for details).

For the content of the courses on clinical nutrition and prevention in

the medical curriculum, see the Education section of this report.

Dietetics

The Dietetics section is providing and improving patient care at UMC

Utrecht and at rehabilitation center ‘De Hoogstraat’. The Dietetics sec-

tion is a national leading light in evidence based dietetics and standard-

ized processes for dietetics professionals.

IT developments

The implementation of an electronic dietetics patient file in 2007 was, as

it seems now, the start of a process of innovation and efficiency. The

skills required for working with the file improved rapidly. Not only did

this file replace almost all paper files, during 2008 the section also devel-

oped several improvements to the system and files. Connections with

other electronic files in the UMC Utrecht were also made. Automatic

correspondence to specialists and partners in primary care organiza-

tions, other hospitals and nursing homes were developed too. From the

files, visits are automatically recorded in the UMC Utrecht registration

and financial records.

As a precursor, the section was involved in a pilot involving electronic

order management and the sounding board ‘New electronic hospital

patient file’. The new patient appointment system was implemented and

Patient Care 95

all systems were prepared for the implementation of the BSN (social

security number).

Evidence-based Guidelines

The development of evidence-based guidelines and product descriptions

(short practical guidelines) is still making progress. The guidelines and

product descriptions provided were, as always, topics for concise (stu-

dent) projects. These included amino acids and free fatty acids in

patients with amino acid metabolism disorders, cystic fibrosis and the

use of vitamin supplements, growth and skeleton age in children with

cystic fibrosis, food perception by nurses in the WKZ children’s hospital,

nutritional status in patients with jaw fixation, body composition in

patients pre and post lung transplantation and energy and protein

requirements in surgical patients. In rehabilitation center ‘De Hoog-

straat’ a malnutrition project was started. This was the first time in more

than 20 years of cooperation.

Educational and Scientific Contributions

In 2008 20 students from Wageningen University, VU Health Care and

from the various Dietetics Academies performed student projects and

worked on practical skills.

The dieticians gave several lectures, workshops and poster presentations

for health care professionals in the Netherlands and other European

countries on topics such as Cystic Fibrosis related Diabetes, ketogenic

diet, PKU patient education systems, cardiovascular disease manage-

ment, head and neck cancer. A course on Nutrition Care Process and

Dietetic Diagnosis was developed and presented in cooperation with the

NPI (Dutch paramedic institute) and the Dutch Dietetic Association. In

2008 and 2009 more than 600 Dutch dieticians will be educated in this

subject. Education on several subjects was provided to several specialist


nursing groups, the nursing training school in Utrecht and dieticians.

The section also hosted a TODU workshop on regional cooperation in

malnutrition. The dietetic section cooperated in the facultative course

on Nutrition and Medicine.

A few scientific articles were published and several articles and book

chapters are in progress.

Training was provided to the dieticians in the form of external courses,

meetings, and conferences (39 individual activities). These activities

took place in the Netherlands and other European countries.

External International, National and Regional Projects

The Dietetics section contributed to several external projects. The most

important are:

- Chairing and vice-chairing a regional oncology group

- Chairing the national academic dieticians working group

- Member scientific advisory committee of the PKU association

Besides these projects, our staff participated in a wide range of (nation-

al) consultation groups.

Internal Projects

Within the UMC Utrecht, the Dietetics sections participated in the fol-

lowing internal projects and work groups:

- Hosting the UMC Utrecht Clinical Nutrition Advice Board, this

enables us to discuss nutritional problems and new insights in dietetics

in a broader clinical context. Implementation of the ‘screening

malnutrition’ advice, the ongoing tube feeding plan for the UMC

Utrecht and the nearly finished UMC Utrecht food policy plan. A

parenteral feeding project was started.

- screening malnutrition, delivering figures and strategy to the board of

directors

Patient Care 97

- implementation of PKU patient education strategies and patient

education materials

- ‘Better eating’ project in the Wilhelmina children’s hospital

- HOOP study (evidence-based treatment for obese patients)

- participation in clinical multicenter studies (ALS study, PHYTON)

- implementing ERAS

- participation in development and implementation of a new hospital

food distribution project

- European tender for a contract on clinical nutrition and infant

formulas

- pilot JCI quality assessment

- JACY (European quality system in hematology)

Besides these projects, dieticians participated in several internal multi-

disciplinary groups to develop, improve and implement evidence-based

and best practice guidelines

Personnel

In 2008 two persons left the department for personal reasons and one

was dismissed. New personnel filled the vacancies quickly. There were no

formal complaints and there were three patient incident reports.


Care provided by the Dietetics in 20081st visit Follow-up visits DME*

Team 1

Outpatients 771 1928 4382

Hospitalized 619 1671 3154

No-show 96 195

Team 2



No-show 31 75

Team 3



No-show 20 73

Rehabilitation centre ‘De Hoogstraat’’ 144 404 610

No-show - -

DME *= 30-minute time units

Patient Care 99

Academic Primary Care in Leidsche Rijn

As of January 2004, the Julius Center has been hosting a network for

academic patient care, located in the newly developed Utrecht district of

‘Leidsche Rijn’. In the next few years, Leidsche Rijn will expand to

become a large suburban area, with approximately 80,000 inhabitants.

The Leidsche Rijn Network offers an excellent opportunity for the Julius

Center to fulfill its ambition of providing academic health care services

in primary care. This involves high quality patient care, closely integrat-

ed with (vocational) training and research. In order to facilitate this,

training facilities will be incorporated into the health centers at Leidsche

Rijn, enabling on-location training of medical students, general practi-

tioners and other health care professionals. Electronic recording of all

aspects of medical care as well as dedicated support staff will provide the

basis for an excellent research environment in the Leidsche Rijn health

centers. Most new inhabitants of Leidsche Rijn are already participating

in the Leidsche Rijn Health project (LRGP), which records their basic

health characteristics and offers instant medical assessments. In future,

this health profile will be related to updated primary medical care data

at the health centers. Medical follow-up of the Leidsche Rijn population

combined with academic research will enable us to develop evidence-

based multidisciplinary patient-centered health care programmes.

Julius Health Centers

One of the ambitions of the Julius Center is to create an academic envi-

ronment in primary care, in which research and medical education are

combined with high quality, innovative patient care. In order to realize

this ambition the Julius Center has been coordinating the development

of the primary health facilities in Leidsche Rijn, the VINEX area of


Utrecht since 2004. In 2008, primary care services were provided to

more than 20.000 inhabitants from four centers of the Julius Health

Centers. In order to provide these services, the Julius Health Centers

employ twenty general practitioners, ten physiotherapists and auxiliary

nursing and administrative staff. In 2008, the centers entered the next

phase in their academic development.

The key features and prerequisites of the next phase of the academic

development and the time frame to develop an integrated research/edu-

cation/patient care environment are described in a detailed development

plan. This process requires close cooperation with primary care partners,

hospital colleagues, patients and other stakeholders. The development

plan, which covers a period of five years, was adopted by the staff and

management team of the Julius Center at the end of 2007.

In 2008 the first part of this next step in the academic development in

the Julius Health Centers was implemented, with the assignment and

training of academic staff for four different clinical fields (cardiovascular

disease, COPD, mental health and diabetes) as well as for academic edu-

cation. The academic patient care programmes that they developed will

be further integrated in daily clinical care from 2009 onwards. In 2009

and 2010 the programme will be extended to eight other clinical fields,

resulting in full implementation of the academic infrastructure in 2012.

Patient Care 101

Unit Health Care Innovations

The focus of the Unit is the study of; i) integrated care and disease man-

agement and ii) emergency services. The first theme consists of three sub

themes: a) the epidemiology of chronic care b)The evaluation of inno-

vative interventions and c) the validation of assessment instruments and

procedures to select patients with a chronic condition for early interven-

tions. The emergency services theme has three comparable sub themes:

- the epidemiology of emergency services provided by GP cooperatives,

emergency departments and ambulance services

- evaluation of innovative emergency interventions and

- validation of assessment instruments and procedures to triage patient

with acute needs.

In 2008, the Unit grew from 17 fte professional staff to 25. They profiled

themselves on the two mentioned themes. Six research grants were

acquired from scientific funds, social funds, and Ministry of Health,

social insurance agencies and health care providers. Ten (2008:6) con-

gresses with a total of 1500 participants and seven (2007:4) courses with

28 participants took place. Two PhD theses, eleven scientific publications

and many reports were published. The group was repeatedly asked to

give guest lectures on scientific and professional congresses. In 2008 the

Unit had a positive financial result.

The Unit of Health Care Innovation participated structurally in the

European Health Leaders Programme, which is a cooperative of five uni-

versities: Utrecht, Budapest, Stockholm, Berlin and Durham (UK). This

course last for eighteen days. The Julius Center was responsible for the

theme of health care innovations and this received a very positive evalu-

ation.


In October, the Julius Center’s Unit for Health Care Innovations orga-

nized a study trip to Kaiser Permanente in Denver (Colorado). The pur-

pose of the trip was set out beforehand and was to acquire know-how on

1 integrated health care (integration of primary health care and

hospital care

2 cooperation between health care providers (= Permanente)

3 design and functioning advances Health Information System and

4 emphasis on preventive interventions.

The study visit offered many eye-openers to the study trip comprising a

group of 30 experienced health care professionals and managers. The

ideas in the trip contributed strongly to the debate in Holland about

cooperation and combined hospitals and Insurance companies.

Patient Care 103

Education 105

Operational support

‘Education is essential, to create awareness for the

quality standards of Good Clinical Practice!’

Mariska Hafkamp, Quality Manager,

Research Quality Assurance Organization


Management Support

The Julius Center’s core activities of research, education and patient care

are supported by a number of services. Management is supported by a

central finance department, a personnel & organization (P&O) depart-

ment and an ICT department. The finance department handles all con-

tracts and other financial matters. The Julius Center is highly dependent

on external funding, such as the European Counsel funds or Dutch

research funds, such as ZonMw. Because the administration of these

funds is very complex, the center devoted much attention in 2008 to

professionalization and staff development. This professionalization has

taken the shape of a renewed planning and control cycle which makes it

possible to manage all financial aspects of the organization. The key-

word in this planning is ‘prognostication’. The P&O department deals

with management development, vacancies and all procedural matters

involving employment. The ICT Department is responsible for the

development and maintenance of an infrastructure that supports both

office automation and scientific research. It provides user support and

Internet development services. The Julius Center website was completely

renewed and updated in 2008.


From CTSU to Julius Clinical Research and Research Support

In the first half of 2008 the Clinical Trial Services unit (CTSU) was

active as it has been in previous years. This included project manage-

ment, monitoring, an outpatient research clinic, quality assurance, help-

desk for questions regarding quality issues and providing a technical

infrastructure for the collection, processing and analysis of data. The

success of the clinical trial services (CTSU) required the repositioning of

these activities. Therefore, in 2008, the Julius Center started to transfer

part of the clinical trial activities to Julius Clinical Research (JCR), an

independent Academic Clinical Research Organization. JCR delivers

high quality clinical trial services to the pharmaceutical industry and the

academic society. at the end of 2008 the process of transferring project

management and clinical monitoring staff to JCR was also started. The

formal transition of the staff from the former CTSU to JCR will take

place in 2009. Research support services that will stay at the Julius

Center include the outpatient research clinic, data management, quality

assurance and the vascular imaging center.

The Julius Center collaborates with institutes from Sydney, Australia and

Minneapolis, USA within the Academic Alliance for Clinical Trials in

sharing knowledge and experience about performing clinical trials and

the use and improvement of quality systems.

Clinical Trial and Services Unit (CTSU)

The CTSU existed until the fall of 2008. CTSU services were available for

internal (Julius Center) and external sponsors. External sponsors could

be other divisions of the UMC Utrecht pharmaceutical and food compa-

nies or other scientific institutes (RIVM, TNO, NVI). The CTSU has


been certified in line with ISO9001:2000 since January 1st, 2005 and has

prolonged this certification in 2008 for another 3 years.

CTSU services included:

- Project Management including the organization, execution and

monitoring of clinical trials from initial design to final publication

- Clinical trial coordination

- Site monitoring

- Site management

- Data management

- End-point adjudication management

- Adverse event reporting

- Clinical Trial Monitoring of mono and multi-center trials based in The

Netherlands and other European countries

- Research Clinic: an out-patient research center fully equipped with

state of the art clinical and diagnostic facilities for carrying out clinical

trials

- Vascular Imaging Center: a center of expertise in vascular ultrasound

imaging and retinal vascular measurements

- Data Management utilizing Teleform® and Research Online

- Quality Assurance and Control in accordance with ICH-GCP

Guidelines and ISO 9001:2000 certification

About 60 persons were working at CTSU, including 10 CRA’s based at

home and in other European countries. They were involved in about 40

different projects.

At the end of 2008 the CTSU services management and clinical moni-

toring project started to become part of Julius Clinical Research. The


other services stayed in the Julius Center and are now called Research

Support.

Research Support

Research clinic

The research clinic is an out-patient research center fully equipped with

state of the art clinical and diagnostic facilities for carrying out clinical

trials in accordance with Good Clinical Practice guidelines. In 2008 the

research clinic was involved in 25 studies. Four of them were new inter-

vention studies. For some other studies the participation was very low.

About 15 persons were working for the research clinic, including

research physicians, research nurses, administrative trial assistants and

project managers. The research clinic has its own database with about

4000 “healthy” volunteers who are interested in taking part as a partici-

pant in a study.

Data Management

The data management department provides high quality data manage-

ment, according to GCP requirements, to facilitate the collection, pro-

cessing, management and analysis of epidemiological data. These servic-

es are available for a broad range of clients: the Julius Center researchers

and research clinic, researchers of other UMC Utrecht divisions and

external parties.

At the end of 2008 there were about 90 ongoing projects in the depart-

ment. Among these projects were clinical trials, observational studies,

cohorts and management information applications.

In 2008 34 new projects started:

- In 17 projects, either paper based (4) or electronic (13), CRF’s were

developed to support data collection for clinical studies. Major studies


are: MOSAR (WP3, WP4 and WP5), CHAMP, LITRA, IC delirium,

SportCor, Topfit, Panacea and Tiki.

- In 17 projects specific databases and applications were designed to

support cohorts, data entry processes, study participant management,

study specific logistics or to gather management information. Major

projects are Isala heart surgery database, Capita, IRIS, MIS onderwijs

and Mondriaan.

- Furthermore, online randomization was implemented for an

additional 8 studies.

About 20 projects were closed in 2008 and at the end of the year the

department had about 15 prospects.

Besides providing data management for studies, courses were given to

researchers on best practices in SPSS. Furthermore, data management

participated within the BROK course to provide training on GCP issues

within data management processes.

This year, the electronic data capture system ‘Research Online’ was fur-

ther developed by our department and extensively used for clinical stud-

ies (13 new studies were implemented). The system, which was initially

developed in 2006, is now being used successfully within 19 studies.

Among these studies are 3 studies granted by the European Commission

(GRACE, MOSAR and CHAMP). Data collection for these studies takes

place within 20 countries. The department uses Research Online to facil-

itate data management in about 75% of all new clinical studies.

The data management department consisted of 13.6 FTEs (16 employees

in absolute numbers).


Quality Assurance

The Julius Center provides services in clinical research that need to be

compliant with ICH-GCP and other applicable guidelines and legisla-

tion. The Julius Center is responsible for the Quality Assurance System

for clinical drug trials performed in the UMC Utrecht (Bureau

Kwaliteitsborging Onderzoek - BKO). It is staffed by Quality Managers

and experienced Project Managers from the Julius Center for Health

Sciences and Primary Care.

The Julius Center’s quality assurance managers provide support and

advice in organizational and regulatory aspects of clinical research and

also supervise and verify adherence to the quality system by staff from

the Julius Center. This is achieved by:

- Training CTSU staff

- Internal audits

- Regulatory advice and support (helpdesk)

- Participation in study teams

- Development and improvement of procedures and tools

- Analysis of performance measurements

Activities related to clinical drug trials include compulsory quality intake

checks before starting the study and helpdesk services for questions

regarding quality issues, training and audits. Since its inception in July

2006, 253 intakes have been performed over 2.5 years. The 2.5 year eval-

uation showed positive feedback from investigators and a general

improvement in quality consciousness. The BKO was audited by an

independent auditor in November 2008. The auditor was very positive

about the UMC Utrecht’s initiative to set up such a Quality System at

the UMC Utrecht. In order to assure the best quality of clinical research

overall at the UMC Utrecht, one of the recommendations from the audi-


tor was to extend the BKO’s mission to cover all WMO related studies,

including studies on medical devices and combined medical device/

medicinal products. Among other things, this will be the recommenda-

tion provided to the Hospital Board of Directors.

Besides BKO GCP training, the Julius Center introduced a 4 day course

in the UMC Utrecht specifically aimed at investigators performing clini-

cal trials: BROK-Basiscursus Regelgeving en Organisatie voor Klinische

onderzoekers. The idea to set up such a specific course was introduced

by the Dutch federation of University Hospitals (Nederlandse Federatie

van Universitaire Medische Centra-NFU). The course was run twice in

2008 and was well evaluated by the participants. The BROK was exam-

ined digitally and scored above national average in the UMC Utrecht.

The course will be continued in 2009.

Vascular Imaging Center

The VIC is a core laboratory facility that supports a range of vascular

measurements, with the emphasis on ultrasound techniques. Since the

start of the VIC in 1997, we have supported a large number of etiologic,

prognostic and therapeutic vascular projects among asymptomatic and

symptomatic men and women from the general population, the outpa-

tient clinic and the hospital using non-invasive techniques.

The activities of the VIC comprise development of measurement proto-

cols, advice on equipment, performance of actual measurements, train-

ing on site and certification, continuous quality assurance and quality

control programmes during the study, quantitative QC/QA, reading of

stored images, data management, statistical analyses and scientific

reporting. All activities are performed according to GCP guidelines, and


documented ‘standard operational procedures’ are available for each

procedure at the VIC, including IT procedures.

For all supported measurements, the VIC provides training and certifi-

cation of technicians for the protocols involved. Training can be given in

Utrecht and on-site using the equipment at the participating center.

Since the start of the VIC in 1997, we have performed more than 20,000

vascular measurements in approximately 6,500 subjects.

Julius Clinical Research BV

July 2008 saw the birth of Julius Clinical Research BV, the successor to

the Clinical Trial Services Unit of the Julius Center.

Julius Clinical Research (www.juliusclinical.com) profiles itself as an

academic CRO (ARO) dedicated to delivering high quality clinical trial

services both to the pharmaceutical industry and to the academic soci-

ety. Its close ties with the UMC Utrecht and the Julius Center enable

Julius Clinical Research to add science to its industry standard processes

that find their way to the international scientific journals such as smart

trial design, independent statistical analysis, quality report writing and

scientific publications. Moreover, its academic roots give Julius Clinical

Research access to an international network of excellent investigators

‘Julius Clinical Research is an ARO which stands for Academic Research Organisation.

The word Academic is not something for a glossy marketing brochure but an essen-

tial aspect of who we are. At Julius Clinical Research we look forward to collabora-

ting with the Julius Center and UMC Utrecht on academic clinical research projects.’

Peter Schoevers, CEO of Julius Clinical Research BV


and hospitals in the relevant therapeutic areas and this provides an

attractive proposition, particularly in relation to the global pharmaceuti-

cal industry.

In 2008, contract negotiations were started between the UMC Utrecht

and Wyeth Pharmaceuticals for the execution of the CAPiTA trial, a

mega-trial in the area of infectious diseases, designed to evaluate the

efficacy of a new vaccine against pneumococcal infections in 85,000

elderly subjects, for which the recruitment phase was scheduled to begin

in the Netherlands during the flu vaccination period of 2008. Although

it was the intention that the establishment of the new company would

be completed well before the start of the CAPiTA trial, by the time Julius

Clinical Research was formally established, the contract with Wyeth had

already been signed and preparations for CAPiTA had already been

started by the Clinical Trial Services Unit of the Julius Center. In view of

the large project organization that had to be established for the CAPiTA

trial in a limited amount of time, it was decided to postpone the transfer

of the CTSU staff to Julius Clinical Research until early 2009, in order

not to complicate the work for CAPiTA. A number of CTSU key staff

members were in-sourced from the Julius Center to fulfill important

project management and clinical trial support activities for CAPiTA. As

a result, although the CTSU staff had not yet been formally transferred

to Julius Clinical Research, a natural cohabitation between CTSU and

Julius Clinical Research came into being. This will provide a sound basis

for a smooth transition in 2009.

For the first months of its existence, Julius Clinical Research has very

much been a CAPiTA project organization only. All attention and energy

has been dedicated to preparing for the big wave of vaccinations in

October and November. While the number of employees on the payroll

was only small, the number of temporary professionals working on

CAPiTA under the auspices of Julius Clinical Research well exceeded 800


during the peak of the first vaccination round. By the end of November,

almost 30,000 subjects had been recruited and vaccinated. In close con-

sultation with the sponsor, it was decided to set up a second vaccination

round in 2009, with the aim of completing recruitment before the start

of the 2009 flu vaccination period.

In spite of the focus on the CAPiTA study, business development activi-

ties were actively started and this led to some interesting and promising

leads. At the close of 2008, prospects for contracting a large international

study in the cardio-vascular area and a national study in the area of

infectious diseases are bright. In addition, a number of investigator initi-

ated studies in the areas of mental disease and public health are under

preparation.

The year 2009 will bring some challenges for Julius Clinical Research.

The recruitment phase of the CAPiTA study must be completed success-

fully before the fall of 2009. The transition of the CTSU staff to Julius

Clinical Research will take place in the second quarter. For some key

areas of our activities, recruitment of new staff will be of vital impor-

tance. Two large projects that are being discussed with pharmaceutical

companies need to be translated into actual contracts.

For Julius Clinical Research’s international aspirations, it is essential that

the collaboration in the Academic Alliance for Clinical Trials

( www. academicalliance.com) is further intensified and expanded.

Discussions with the other partners in the AACT are propelled by the

prospect of another large international collaborative project.

We are looking towards the future at Julius Clinical Research with confi-

dence and excitement.

Personnel and finances

‘If you think education is expensive, try ignorance’

Derek Bok, President, Harvard University 1971-1991

Marco Perdon,

Operational Support, Educational Finances

Personnel and finances 121

Personnel, Figures

Absolute numbersScientific Support Care TOTAL

Male 74 32 1 107

Female 165 58 25 248

TOTAL 239 90 26 355

FTE

Male 47.35 28.96 0.67 76.97

Female 110.13 39.89 19.73 169.75

TOTAL 157.47 68.85 20.40 246.72

Average FTE

Male 0.64 0.91 0.67 0.72

Female 0.67 0.69 0.79 0.68

TOTAL 0.66 0.76 0.78 0.69


Personnel, Listing 2008* Adjunct faculty (in Dutch ‘Nul-aanstelling’)

Management

Management team

Graaf, Y. van der, Prof. MD, PhD

Grobbee, D.E., Prof. MD, PhD

Hoes, A.W., Prof. MD, PhD

Starre, M. van der, MSc

(until August 2008

Lieshout, B.C. van, MSc (a.i.)

Staff

Kluijtmans, M., PhD

Secretariat

Braun, H.A.

Hartog, M.A. den

Kuijer-Eck, M.C.E. van

Kusters-Ritman, J.C.

Vries, G. de

Clinical Epidemiology

Abeelen, A. van, MSc*

Algra, A., Prof. MD, PhD

Ameijden, E.J.C. van, PhD*

Appelman, A.P.A., MD, PhD

Arts, I., MSc*

Asselt, K.M. van, MD

Baan, F.H. van der

Baart, A.M.*

Baas, A.F., PhD*

Bakker, L.T.

Bauer, F., MSc

Bax, L., MD*

Beulens, J.W.J., PhD

Beus, M.F. de, MD

Bhoo Pathy, N., MD*

Bliek, J.B.

Blom, S.S.A.H.

Bonten, M.J.M., Prof. MD, PhD

Boonacker, C.W.B., MSc

Bootsma, M.C.J., PhD

Bots, M.L., MD, PhD

Bouwmeester, W., BSc

Brouwer, B.G., MSc*

Brussee, J.E., PhD

Dasrath, U.

Dekker, M.S.*

Derde, L.P.G., MSc

Dieren, S. van, MSc

Dogan, S., MSc

Dool, C. van den, MSc

Drijvers, J.J.M.M.

Duijnhoven, F.J.B. van, MSc

Edlinger, M., MSc

Elbers, C.C., MSc


Elias, S.G., PhD

Ettema, R.G.A.*

Feenstra, A.

Fischer, K., MD, PhD

Fraza, A.

Gast, G.C.M., MSc

Geerlings, M.I., PhD

Geerts, C.C., MD

Gerritsen, L., MSc

Gils, C.H. van, PhD

Gondrie, M.J.A.

Gorcum, A.N. van

Gourieva, T.V.

Greving, J.P. PhD

Grigoryan, L., MD, PhD

Groeneveld, J. PhD

Groenwold, R.H.H., MSc

Grool, A., MD

Groot, J.A.H. de, MSc

Groot, M.C.H. de*

Hady, M.S.A.*

Harimurti, K.H.*

Heijden, G.J.M.G. van der, PhD

Hendrix, A*

Hertogh, E., MSc

Herve, H.*

Hoorn-van Kempen, M.H. van der

Hopman, M.C.

Huijts, S., MD

Idris, B.I.*

Janssen, K.J.M., PhD

Kamphuis, M.H., MSc*

Knol, M.J., MSc

Knoops, A.J.G., MSc

Kretzschmar, M., PhD

Kurniati, N., MD*

Laan, W., PhD

Lokate, A.J.M., MSc

Lucas, Y.M.

May, A.M., PhD

Melsen, W.G., MSc*

Metselaar-van den Bos, J.J.

Molenaar, E.A.,PhD

Monninkhof, E.M., PhD

Moons, K.G.M., Prof. PhD

Mosterd, A., MD*

Nijdam, M.E., MSc

Noord, P.A.H. van, MD, PhD

Onland-Moret, N.C., PhD

Peelen, L.M., MSc

Peeters, P.H.M., Prof. MD, PhD

Perales, L.E.M.

Peters, H.G.M., MD*

Pijl, A.G.

Plantinga, Y., PhD

Roest, S.J.A.M.M.

Rovers, M.M., PhD

Schilder, A.G.M., PhD*

Schouw, Y.T. van der, Prof. PhD

Sluijs, I.S., MSc


Smit, H.A., PhD*

Soedamah-Muthu, S.S., MD, PhD

Spoel, O.P. van der, MSc*

Stefansdottir, G.

Stegenga, B.T., MSc

Stolk, R.P., Prof. MD, PhD*

Stolwijk, A.

Tjang, Y.S.*

Toll, D.B., MSc

Trapman, J.P., MSc

Uijl, I.E.M. den, MSc

Uijl, S.G., PhD

Uiterwaal, C.S.P.M., MD, PhD

Vaartjes, C.H., MSc

Velthuis, M.*

Vergouwe, Y., PhD

Verheugt, C.L., MD*

Verheus, M., MSc

Verkooijen, H.M., MD

Vermeulen, R.C.H., PhD*

Vlek, A.L.M., MD*

Vrieling, A., PhD

Wallinga, J., PhD

Warnier, M.J., MD*

Weerd, M. de, MSc

Welsing, P.M.J., PhD

Werkhoven, H. van

Westendorp, G.W.

Winden, A.W.J. van, MSc

Zafarmand, M.H., MD, PhD*

Secretariat

Fraza, A.

Haks-Schoonderwoerd, T.L.T.M.

Houthuysen, J.M.

Knegt, M. de

Koopmans, A.

Meegdes-Kuiperij, H.

Noppen-Pinkaarts, D.J.W. van

Paltan, S.

Wesselink-van Meerten, I.E.

General Practice

Appelman, C.L.M., MD, PhD

Avendonk, M.J.P. van, MD

Balen, F.A.M. van, MD, PhD*

Bartelink, M.E.L., MD, PhD

Beem, E.E., PhD

Bij, S. van der

Bijkerk, C.J.*

Bijkerk, C.J., PhD*

Bont, J., MD*

Bosman, M., MSc

Bossenbroek, J.G.

Both, L

Broekhuizen, B.D.L.

Bruggen, J.A.R. van, MSc

Bruin, M.L. de, MSc*

Bruins Slot, M.H.E., MD*

Cleveringa, F.G.W., MD

Coenen, V., MD


Decanniere, A.B.A.

Donk, M. van den, PhD

Du dok van Heel-Sakkers, P.M.A.,

MSc

Duijn, H.J. van, PhD

Eenige, M.M. van, MSc

Engelsen, C. den, MD*

Essen, G.A. van, MD, PhD

Geersing, G.J., MD

Gorter, K.J., MD, PhD

Graaff, M.E.

Hak, E., MD, PhD

Hart, H.E., MD, PhD

Helsper, C.W., MD*

Hendriks, A., MSc*

Hoekstra, J.F., MSc*

Jacobs, P.C.A., MD*

Janssen, P.G.H., MD

Kelder, J.C., MSc*

Keyer, H.*

Kreuger, M.J.O.

Kuijper, E.C.

Kuyvenhoven, M.M., PhD

Looijmans-van den Akker, I., MD*

Mennink, M.

Mol, S.S.L., PhD

Mujakovic, S., MSc

Numans, M.E., MD, PhD

Opstelten, W., MD*

Oudega, R., MD, PhD

Oudejans-Mooijaart, I., MD*

Pijpers, E.J.

Raat, A.M.C., MD

Rambharose, V.R.

Raupp, G.E.M.

Rikken, L.H.M., MD

Rutten, F.H., MD, PhD

Rutten, G.E.H.M., Prof. MD, PhD.

Sachs, A.P.E., MD, PhD

Scheele, E.A.E., MSc

Scheltens, T.

Siccama, R., MD

Smeets, H.M., MD

Velden, A.W. van der, PhD

Venekamp, R.P., MD*

Verheij, Th.J.M., Prof. MD, PhD

Visser, A.C.E.

Vo orst Vader-Stikkel, M.L.C. van,

MSc

Vreugdenhil, H.A.E., PhD

Vugt, S.F. van, MD

Wermeling, P.R.

Wit, N.J. de, MD, PhD

Secretariat

Blijleven, E.M.

Dijk-Okla, M.K. van, MA

Laurens, I.C.

Weel-van der Heijden, A.A.H.M.


General Practice Vocational

Training

Albert, M.C.G.A., MSc

Barels, I.H., MD

Beek, C. van, MD

Belgraver, A., MD

Boer, L.J. de, MD, PhD

Bruggen, E. van, MSc

Cingel, M.I. van der, MSc

Dagnelie, C.F., MD, PhD

Djajadiningrat, M., MSc

Dool-Mulder, M.S. van den, MD

Feijen, M.K.E., MSc, MD

Filippo, M., MD

Graaf, P. de, MD

Grunt, N.G. de, MD

Halteren, M.M. van, MD

Hemert, M.M.H.M. van, MD

Hendrickx, E.F.H.M., MD

Hirsch, R., MD

Jagt, E.J. van der, MSc

Konings, J.E., MD

Kraan, W. van der, MD

Kruithof, P.J., MSc

Ledoux, M.E.V., MD

Leeuwen, A.J. van, MSc

Lennep-Sanders, A.R.J. van, MD

Maaijen, J., MD, PhD

Maillé, A.R., MSc, PhD

Mathot, M.A., MD

Mutsaets, E.J.M., MD

Pieters, H.M., MD, PhD

Quartero, A.O., MD, PhD

Rompelman, S.E.C., MD

Schouten, M., MSc

Stempvoort, W.M. van, MD

Schellekens, M.J.F.M., MD

Terluin, M., MD

Tjin-a-Ton, J., MD

Truijens, L., MD

Vermeulen, M.I., MD

Vernooy, C., MSc

Vooren, R.C. van de, MD

Vossen, S., MSc

Wilt, M.J.G. de, MSc

Zwart, D.L.M., MD

Zwart, S., MD, PhD

Secretariat

Bogaards-Godschalk, M.

Groothedde-Zeilstra, R.

Hoeven-van Ingen, S. van den

Ho even-van Vriesland, I.A. van

den

Honk, S.M. van

Jordan-Carels, H.M.

Mertens, W.

Nusse, C., MSc

Wolf-Verschuure, T.W.P.M.

Zwijnenburg, M.


Leidsche Rijn, Julius Health Care

Centers

Damme, R.A.E. van, MSc

Public Health / MTA / Medical

Ethics

Public Health/ Unit Health Care

Innovations

Althuis, E.I. van

Belkadi, H., MSc

Berk, M.B., MSc

Biesaart, M.C.I.H., MSc

Boot, J.M.D., MSc*

Bos, N., MSc

Bours, P.H.A., PhD

Derckx, V.L., MSc

Haneveld, R.W., PHS, MPH*

Hermsen, L.A.H., MSc

Leeuw, J.R.J. de, PhD

Ros, W.J.G., PhD

Schrijvers, A.J.P., Prof., PhD

Simkens, A.B.M., MSc

Smit-Kam, M.A.

Stel, H.F. van, PhD

Sturms, L.M., PhD

Swaans, I.J.E.M., MD

Touwen, I.D.

Trappenburg, J.C.A., MSc

Urbanus-van Laar, J.J.N., PhD

Veenendaal, L.J. van, MSc

Vliet, M.J.H. van, MSc

Weert-van Oene, G.H. de, PhD

Wulp, I. van der, MSc

MTA/KEA

Borkent-Raven, B.A., MSc

Buskens, E., MD, PhD*

Heeg, B.M.S., MSc*

Hout, B.A. van, Prof. PhD

Janssen, M.P., MSc

Koffijberg, H., PhD

Mangen, M., PhD

Poel, C.L. van der, PhD*

Ramwadhdoebe, S., MSc

Verschuuren, M., PhD

Wit, G.A. de, PhD

Medical Ethics

Bernabe, R., MA

Bredenoord, A.L., MA

Delden, J.J.M. van, Prof. MD, PhD

Eikelboom, J.I., MD

Graaf-Verhave, R. van der, MSc

Huisman, F.G., Prof. PhD

Stuifbergen, M., MSc*

Thiel, G.J.M.W. van, MSc

Secretariat

Bruin, C.E.T. de

Esser, A.


Hageman-Raatgever, G.M.C.

Meegdes-Kuiperij, H.

Munsterman, J.

Sies, C.P.

Straaten, M.C. van

Nursing Science

Berg, M.J. van den, MSc

Bijl, J.J. van der, PhD

Boer, F. de, PhD

Fluttert, F.A.J., MSc

Gamel, C.J., PhD

Goverde, C.A.M., MSc

Hooft-Leemans, G. van der, MSc

Horenberg, A.H., MSc

Kars, M.C., MSc

Korte, M.C. de, MSc

Linge, R.H. van, PhD

Meijel, B.K.G. van, PhD*

Moes, H., MSc

Oosterom, M., MSc

Ros, W.J.G., PhD

Schoonhoven-Noorland, L., PhD*

Tuijtel, G.H.

Secretariat

Dekker, M.S.*

Garden, B. van

Biostatistics

Kruitwagen, C.L.J.J., MSc

Martens, E.P., PhD

Pestman, W.R., PhD

Schipper, M., PhD

Stellato, R.K., MSc

Tweel, I. van der, PhD

Westers, P., PhD

Secretariat

Agterhuis, E.

Nutritional Science/Dietetics

Alst, S.C.G. van, MSc RD

Broekman-Peters, N., RD

Bruin, M. de, RD

Carbasius Weber, E.C., RD

Halen-Kemp, K. van, RD

Harten, J.N.N. van, RD

Heest-Cooman, P.D. van, RD

Hiemstra, G.K., RD

Hoekstra, T., PhD

Hollander-Kraaijeveld, F.M., RD

Hurk, Th.A.M. van den, RD

Iestra, J.A., PhD

Jongh-Kampherbeek, E.H. de, RD

Lamarche, N., RD

Leermakers-Vermeer, J.M.P., RD

Los, M., RD

Losper, S.C., RD


Luyt, J.W.H. van der, RD

Michelsen-Huisman, A.D., RD

Renken-Terhaerdt, J.W.M., RD

Roos, N.M. de, PhD

Runia, S., RD

Schregardus, D., RD

Schreurs, J.C.M., RD

Somer, M., RD

Steenhagen, E., RD

Timmer, C., MSc, RD

Woestenenk, J.W., MSc, RD

Secretariat

Donker-Spronk, M.

Gil, A.

Maarseveen-Hendriks, J.M. van

Clinical Trial Services Unit

Bak, A.A.A., MD, PhD

Bobbink, W.G., PhD

Bolkenbaas, M. MD*

Brink, J.J. van de

Brugman, C.C.W., MSc

Caspers, E.

Dijk, M.P.M., MSc

Dongen, A. van

Eck, J.W.M. van, MSc

Ehrencron, M.C.T.

Groot, C.G.E.M.

Haars, G., PhD

Hafkamp, M.C., MSc

Hemert, G.B. van

Holleman, P.

Izeboud, L.D.

Kowal, I.

Kuiper, M.W., MSc

Leeuw, M. de, MSc

Meer-Poelwijk, M.J. van der

Meijers, G.E.P.M.

Menninga, K.E.

Molen-Dokter, J. van der

Mooiweer-Boogaerdt, D.B.

Nijssen, K.M.

Noordzij-van Willligen, J.J.

Ophorst-den Besten, H.A.

Pas, C.B.G.H. van der, MSc

Ram, E.A.M.

Scholten, M.J.G.

Sies, B.W.P.M.

Sikking, I.E.M.

Stern-vd Heuvel, J.J.M. van der

Stooker-Brouwer, J.A.G.

Suiker, A.M.H., MSc

Tims-Polderman, C.A.J.

Vendrig, L.

Vissers, I

Vlist, L. van der

Weerd, T.C. van der

Wijnia-Lemstra, E.A., MSc

Williamson, K., PhD*


Winter, R.F.J. de*

Wisse, H.

Zuidema, J.A., MD

Zwart, L.M.

Secretariat

Eden, P.M. van

Kubicarova, M.

Linnebank-Hillebrand, N.

Maekelbergh, C.E.

Verreussel, M.H.G.H.

Wilken, R.C.M.

Data Management

Abbel, O.

Beurden, M.M. van

Boekema-Bakker, N.

Dijker, B.D., MSc

Doest, D. ter

Geerts, A.C., MSc

Haak-van Mourik, M.L. van den

Hemert, S.J.M. van

Heuveling, L.M.

Leus, F.

Lom, R. van

Maaskant, J.W.

Petersen, R.B. van, MSc

Schotsman, J.J., MSc

Slotboom, B.J.

Spithoven-van Leeuwen, E.H.J.

Veen, R.E.R., MSc

Zuithoff, N.P.A., MSc

Zwerver, J.

Management Support

Finances and Facilities

Baars, W.D.

Bekkers, M.H., MSc

Booden, K.

Dettingmeijer, R.*

Horstink, G.H.M.

Kesteren, H.G.B van

Keurs, H. ter

Meijering, G.*

Perdon, M.

Plomp, E.P.

Rietveld-Ernst, M.

Rijn, C. van

Schenk, S.

HRM

Molenaar, J.J.

Schaik, A.E.L. van

Secretariat

Blom K.

ICT

Bouabdellaoui-Abahai, S.

Dijk, P.H. van


Frens, H.C.

Harkema, J.C.

Jonge, J. de

Nelissen, R.

Vos, M.

Communication

Avezaath, M.E. van*

Werff, M. van der

Wolfslag, G.*


Financial Report

Financial Overview 2008

Costs Income

UMC Personnel Science € 4,930,081 -€ 1,732,310

Care € 1,042,827 -€ 49,298

Support € 1,543,201 -€ 1,016,988

GPVT € 2,776,475 -€ 3,315,247

Project SMART € 339,715 -€ 302,549

Julius Healthcare centre € 325,097 -€ 318,874

Running costs Science € 1,011,067

Care € 11,448

Support € 211,009

GPVT € 501,024

Project SMART € 70,114

Julius Healthcare centre € 13,548

Investments € 196,638

UMC Budget -€ 6,236,979

Total € 12,972,245 -€ 12,972,244

Projects Personnel

Commercial € 4,109,075

Non-commercial € 1,388,834

Running costs Commercial € 1,593,584

Non-commercial € 82,441

External budget -€ 7,173,933

Total € 7,173,933 -€ 7,173,933

Grand total € 20,146,177 -€ 20,146,177


Organizations and Companies Providing Funding

ADIR

AGIS Zorgverzekeringen nv

Akzo Nobel nv

Astmafonds

Astra Zeneca

Bayer Health Care

Bowling Pfizer

Centrum Maliebaan

College van Zorgverzekeraars

Danone Research bv

Diabetes Fonds

Districts Huisartsen Vereniging

DGV Nederlands Instituut voor Verantwoord Medicijngebruik

European Union

Eli Lilly Nederland bv

Gemeente Amsterdam

George Institute for International Health

GlaxoSmithKline

Imperial College London

Internationale Stichting Alzheimer Onderzoek

Koningin Wilhelminafonds (Nederlandse Kankerbestrijding)

Lipid Nutrition bv

Landelijk Centrum Verpleging & Verzorging

Landelijke Stichting Beheer Kruiswerk

Medpace

Merck Sharp en Dohme

Ministerie van Volksgezondheid , Welzijn en Sport

Nederlandse Hartstichting


Nederlandse Organisatie voor gezondheidsonderzoek en zorginnovatie

(ZonMW)

Nederlandse Vaccin Instituut

Novartis Pharma bv

Novo Nordisk Farma bv

Nutricia

NWO

Organon Nederland bv

Pfizer

Pharmanet

RIVM

Sanofi-Aventis

Sanquin

SBOH

Servier

Schering Plough

Sticares

Stichting centraal fonds Reserves Voormalig Vrijwillige

Ziekenfondsverzekering

Stichting Koningsheide

Stichting RIPAG

Stichting Vascular Research Netwerk

Stichting Vecozo

Stichting tot steun VCVGZ

Strangeways Research

The Icelandic Heart Association

The Stanley Medical Research Institute

TNO-voeding

UMC Utrecht

University of Durham


University of Oxford

VU Medical Centre

Wyeth Pharmaceuticals Inc.

World Cancer Research Fund

World Health Organization

Zorggroep Almere

Research projects 137 Research 137

Research projects (2008)

‘We all know how important it is to learn from our

own mistakes, but for improving patient safety the

challenge is to enable others to learn from our

mistakes as well’

Dorien Zwart, Assistant Professor General Practice

Vocational Training

Research projects 139

Cardiovascular Diseases

PhD projects, finished 2008

Name Title JC Discipl

Appelman, A.P.A. (see also

Mental Health)

Brain atrophy in patients with arterial disease. The SMART-MR study

Joint CE

Bax, L. Renal function and atherosclerotic renovascular disease

Joint CE

Brouwer, B.G. SMART risk factor screening in patients at high vascular risk

Intern CE

Dogan, S. Carotid intima-media-thickness: studies into methodological aspects

Intern CE

Eck, J.W.M. van (see also Theor Epi)

Outcomes after pacemaker implantation. Results of the FOLLOWPACE study.

Intern CE

El Fakiri, F. Prevention of cardiovascular diseases in deprived neighbourhoods

Extern GP

Gorter, P.M. Insulin resistance and adipose tissue in the development of vascular diseases in high-risk patients

Joint CE

Hajer, G.R. Vascular risk factors and adipocyte dysfunction in metabolic syndrome

Joint CE

Halkes, P.H.A. ESPRIT (European/Australasian Stroke Prevention in Reversible Ischaemia Trial) and related studies

Extern CE

Janssen, P.G.H. Screening for type 2 diabetes in general practice

Intern CE, GP

Knol, M.J. (see

also Mental Health)

Depression and diabetes. Methodological issues in etiologic research

Joint CE

Koffijberg, H. New decision analytical models for management of intracranial aneurysms

Intern MTA


Lebrun, C.E.I. Determinants of physical aging among healthy postmenopausal women and their relation with serum hormone levels

Extern CE

Molenaar, E.A. Obesity matters: Findings in the Utrecht Health Project and the Framingham Heart study

Intern CE, GP

Pruissen, M. Prothrombotic genevariation and cerebral ischaemia ofarterial origin

Extern CE

Rutten, A. Multi-detector row CT of the heart: methodological evaluation and application in high-risk patients

Extern CE

Tjang, Y.S. Predicting outcome of heart transplantation

Joint CE

Toll, D.B. (see

also Theor. Epi.)

Excluding Deep Vein Thrombosis in primary care: validation, updating, and implementation of a diagnostic rule

Intern CE, GP

Zafarmand, M.H.

Genetic risks for cardiovascular diseases Intern CE

PhD projects, ongoing


Abeelen, A.F.M. van

Dutch famine and cardiovascular disease

Joint CE

Arts, I. Determinants of disability in older persons

Joint CE

Avendonk, M.J.P. van

Insulin therapy in diabetes type 2 patients in general practice

Intern GP

Baan, F.H. van der

Optimising the benefits and safety of new drugs: prospects pharmacogenetics/-genomics, safety monitoring

Intern CE

Bauer, F. IOP Genomics project: The role of inflammation in obesity-induced type 2 diabetes

Intern CE


Beelen, R.M.J. Long-term effects of traffic-related air pollution on respiratory and cardiovascular mortality.

Extern CE

Berg, M.J. van den

Expert patients as a coach in a self-management program for newly diagnosed patients with diabetes type 2

Joint GP, NS

Beus, M.F. de SPORTCOR Sudden cardiac arrest and electrocardiographic patterns in athletes

Joint CE

Bijker, J. (see

also Theor. Epi.)

Intra-operative hypotension and adverse outcome after surgery

Joint CE

Bilecen, S. (see

also Theor. Epi)

Transufion strategies in cardiac surgery Joint CE

Boelhouwer-Jacobsen, D.E.

Efficacy of tibolone and raloxine on the maintenance of muscle strength, bone mineral density and cognitive function in late postmenopausal women.

Extern CE

Boonman-de Winter, L.J.M.

Heart failure in diabetes Extern GP

Bozkurt, O. (see

also Mental Health)

UDES project pharmacy Joint CE

Bruggen, J.A.R. van

Quality of diabetes care in general practice

Intern GP

Bruggink-André de la porte, P.W.F.

Effects of heart failure management programmes

Extern CE, GP

Bruins Slot, M.H.E. (see also

Theor. Epi.)

Improving the early diagnosis of myocardial infarction in primary care: the added value of a rapid assay to detect heart-type FABP, a novel marker of myocardial injury – PhD project 2.

Intern CE, GP, MTA

Cleveringa, F.G.W.

Diabetes care Inplementation Study (DIS)

Intern CE, GP


Dekker, M.S. FAME-ER, Improving the assessment of patients presenting to the emergency room with suspected myocardial infarctation: the diagnostic value of h-FABP, an early biomarker of cardiac injury

Joint CE, GP

Dieleman, S. (see also Theor. Epi)

Cognitive decline and long term outcome after cardiac surgery

Joint CE

Dieren, S. van Optimizing the prediction of absolute CVD risk among type 2 diabetes patients

Intern CE, GP

Elbers, C.C. Role of inflammation in obesity-induced type 2 diabetes, Phd study

Intern CE

Emmelot-Vonk, M.H.

Effects of testosterone suppl. On functional mobility, quality of life, body composition, cognitive function, vasc. Ageing, and bone mineral density in testosterone deficient men, PhDproject1

Intern CE

Engelsen, C. den

IJSCO-2: IJsselstein Study of Central Obesity-2

Intern CE, GP

Ettema, R.G.A. (see also Theor. Epi.)

Improving outcomes of cardiac surgery in elderly patients

Joint CE

Gast, G.C.M. Women with climacteric complaints, a group with a net benefit of postmenopausal hormone therapy?

Joint CE

Geersing, G.J. (see also Theor. Epi.)

Diagnosis of pulmonary embolism in primary care: The AMUSE 2 study

Intern CE, GP

Geerts, C.C. The relation between early childhood obesity and arterial disease

Intern CE

Gerritsen, L. (see

also Mental Health)

Psychological stress and depression as risk factors for cognitive decline and Alzheimer’s disease

Intern CE

Gondrie, M.J.A. (see also Theor. Epi.)

PROVIDI: Prognostic value of unrequested information in diagnostic imaging

Intern CE


Grool, A.M. (see

also Mental Health)

Cerebral small-vessel disease and depression in patients with manifest arterial disease: cause or consequence?

Intern CE

Hendrix, A. The yield of cardio-genetic screening of 1st degree relatives of sudden cardiac and unexplained death victims <45 y (CAREFUL)

Joint CE

Idris, B.I. (see also

Theor. Epi.)

Long-term outcomes in cardiac surgery Intern CE

Jacobs, P.C.A. Beyond clinical diagnosis: the prognostic value of unrequested information in diagnostic imaging (PROVIDI)

Joint CE

Jong, S.E.C.A. de

(DREAM)on: Dutch Randomised Endovascular Aneurysm Management Trial – 2nd part.

Extern CE

Jongen, L.M. Cerebral perfusion and cerebral vascular morphology in patients with symptomatic carotid artery stenosis

Extern CE

Kelder, J.C. Diagnostic strategies in patients suspected of heart failure

Intern CE, GP

Knoops, A.J.G. (see also Mental

Health)

The etiology of Alzheimer disease: an innovative hypothesis of depression, vulnerability an biological interaction

Intern CE

Kurniati, N. HIV infection in children - AsiaLink CE-EBM

Intern CE

Laar, F. van de Nutritional and pharmaceutical treatment aspects in newly diagnosed type 2 diabetes patients in general practice

Extern GP

Lugt, R. van der Addition 2 Intern CE

Maessen, M. Determinants of end-of-life decisions in ALS: prospective study

Extern CE

Mazairac, A.H.A.

Cost effectiveness of increased convective clearance by online hemodiafiltration on all cause mortality in chronic hemodialysis patients: the CONTRAST study

Joint CE


Meijs, M.F.L. Non invasive cardiac imaging Joint CE

Nijdam, M.E. Elevated blood pressure in young adults Intern CE

Oudejans-Mooijaart, I.

Diagnosis of heart failure in the elderly Extern CE

Penne, E.L. Aspects of online hemodiafiltration in chronic hemodialysis patients: the CONTRAST study

Joint CE

Regieli, J.J. Prognosis in ischemic heart disease. Impact and molecular determinants of collateral circulation – the SMART study and REGRESS trial cohorts

Joint CE

Scheltens, T. Prevention of cardiovascular diseases in primary care

Intern CE, GP

Siccama, R.N. (see also Theor. Epi.)

Diagnosis of venous thromboembolism in the elderly: The VT elderly study

Intern CE, GP

Sluijs, I.S. The effect of environmental as well as genetic factors on selected biomarkers of pathophysiological pathways thusfar known to be involved in the ethiology of type 2 diabetes

Intern CE

Spoel, O.P. van der (see also Theor.

Epi.)

Improving the early diagnosis of myocardial infarction in primary care: the added value of a rapid assay to detect heart-type FABP, a novel marker of myocardial injury – PhD project 1.

Intern CE, GP, MTA

Sol-de Rijk, B.G.M.

Self-management of vascular riskfactors Extern CE

Svircevic, V. (see

also Theor. Epi.)

Optimal anesthesial techniques in cardiac surgery

Extern CE

Uijl, I.E.M. den Long term outcome of mild and moderate haemophilea

Intern CE

Vaartjes, C.H. Cerebrovascular disease and peripheral arterial disease in the Netherlands: incidence and prognosis

Intern CE

Verheugt, C.L. Prognosis of adults with congenital heart disease in the CONCOR national registry

Intern CE


Vlak, M. Triggers for rupture of intracranial aneurysms

Extern CE

Vlek, A.L.M. Parameters of cardiovascular disease-the SMART study (definitive title to be decided)

Intern CE

Voorneman, I. Beyond expectations Extern GP, Psych

Vos, A.M. de Cardiac imaging in patients with peripheral arterial disease

Joint CE

Weerd, M. de Chronic renal insufficiency in the Netherlands, incidence and prevalence. + Is screening of asymptomatic carotid stenosis to prevent stroke risk cost effective

Intern CE

Weerd, N. de Early indicators on benefit of online hemodiafiltration in chronic hemodialysis patients: the CONTRAST study

Extern CE

Wermer, M. Aneurysm Screening after surgical Treatment in Ruptured Aneurysms (ASTRA)

Extern CE, MTA

Westerhuis, M.E.M.H. (see

also Theor. Epi.)

The cost-effectiveness of ST-analysis of the fetal electrocardiogram as compared to fetal blood sampling for intrapartum monitoring: an individual controlled trial

Joint CE

Zaane, B. van (see also Theor. Epi.)

Diagnostic value of an innovative non-invasive diagnostic to determine the grade of atherosclerosis before sternotomy in patients scheduled for cardiac surgery

Joint CE


Other projects, finished 2008


Bobbink, W.G. The IJsselstein screening for central obesity to detect metabolic syndrome

Intern CE, GP

Bots, M.L. Possible effects of supplementation with cis-9, trans-11 conjugated linoleic acid on markers of atherosclerosis

Intern CE

Bots, M.L. Cardiac imaging and risk of CVD PAD patients: GROUND study

Intern CE

Other projects, ongoing


Berg, M.J. van den

Expectations and preferences of people with type 2 diabetes mellitus with regard to changes in primary diabetes care

Intern CE, GP

Beulens, J.W.J. Nutrition, type 2 diabetes and cardiovasular disease

Intern CE, NS

Bots, M.L. Effects of increased convective clearance by online hemodiafiltration on all cause mortality in chronic hemodialysis patients. (CONTRAST)

Intern CE

Bots, M.L. Optimal risk factor management in CRI patients and risk of CVD events: MASTERPLAN

Intern CE

Bots, M.L. Carotid intima-media thickness measurement (CIMT): is it useful for clinical practice?

Intern CE

Bots, M.L. Polypill trial (Pill Pilot) Intern CE

Donk, M. van den

Quality of life in screen detected type 2 DM patients

Intern CE, GP

Graaf, Y. van der Soedamah-Muthu, S.S.

SMART: Second Manifestations of ARTerial disease

Intern CE


Greving, J.P. Balancing the risks and benefits in primary prevention. Development of an individualised approach.

Intern CE

Grobbee, D.E. Soedamah-Muthu, S.S.

ADVANCE: Action in Diabetes and Vascular Disease, an international multicenter clinical trial on the effects of Perindopril-Indapamide and Glicazide on cardiovascular disease in patients with diabetes mellitus type 2

Intern CE

Kluijtmans, M. IPD analysis of on- versus off pump coronary bypass surgery

Intern CE

Koffijberg, H. Cardiovascular prevention at old ages, competing risks, competing costs, frailty and indirect medical costs

Intern MTA

Linden, M.W. van der

Cognition in screen/detected patients with type 2 diabetes mellitus in primary care± two and five years follow/up after randomisation towards intensive or standard treatment

Intern CE, GP

Onland-Moret, N.C.

Role of inflammation in obesity-induced type 2 diabetes

Joint CE

Peelen, L.M. (see

also Theor. Epi.)

Theoretical epidemiology in cardiovascular surgery

Intern CE

Peeters, P.H.M. (see also Cancer)

PROSPECT: European prospective investigation into cancer and nutrition

Intern CE

Peeters, P.H.M. (see also Cancer)

EPIC-nl; European Prospective Investigation into Cancer and nutrition-Netherlands

Joint CE

Peeters, P.H.M. (see also Cancer and

Theo. Epi.)

Innovation of dietary assessment methods in epidemiological studies and public health (IDAMES)

Extern CE

Rutten, G.E.H.M.

NAVIGATOR: Efficacy and safety of long term administration of nateglinide and valsartan in the prevention of diabetes and cardiovascular outcome

Intern GP

Schouw, Y.T. van der

European Prospective Investigation into Cardiovascular diseases (EPIC-Heart)

Intern CE


Schouw, Y.T. van der

Nederland de Maat genomen Joint CE

Sonsma, A.C.M. Application of nurse practitioners at the vascular center

Intern CE

Verheus, M. Does equol-producer capacity determine beneficial effect of soy?

Intern CE

Wamsteker, E.W.

HOOP-study: Baseline expectations and the effect of weight reduction therapy. Does changing baseline expectations prevent undesired weight gain within the first two years after treatment?

Intern NS

Welsing, P.M.J. EBM education en rheumatology research

Joint CE


Infectious Diseases



Bont, J. Lower respiratory tract infections in the elderly: Prognostic studies in primary care

Intern GP

Dool, C. van den

Prevention of influenza in health care settings: models and observations

Intern CE, GP

Jong, B.M. de Lower respiratory tract illness in young children: Predictors of disease and health care utilization

Joint CE, GP

Kempen, E.E.M.M. van

Transportation noise exposure and children’s health and cognition

Extern CE

Scholtens, S. Breastfeeding, overweight and asthma in Dutch children. The PIAMA birth cohort study.

Extern CE

Suarthana, E. Predicting occupational lung diseases Joint CE

Visscher, S. Bayesian network models for the management of ventilator-associated pneumonia

Extern CE

Zuidgeest, M.G.P.

Children and asthma medication. When is that inhaler just a breath away?

Extern CE



Aardweg, M.T.A. van den

Effectiveness of adenoidectomy in children with recurrent upper respiratory tract infections

Extern CE, GP

Ammerlaan, H.S.M.

MRSA, clinical epidemiologie Extern CE


Bolkenbaas, M. 13-valent pneumococcal conjugate vaccin efficacy in prevention in prevention of pneumococcal CAP and IPD, efficacy in primary care

Intern CE

Boonacker, C.W.B. (see also

Theor. Epi.)

Optimizing the transferability and applicability of trial results to other countries

Intern CE

Broekhuizen, B.D.L. (see also

Theor. Epi.)

FRESCO study: Diagnostic Strategies for COPD in coughing patients in general practice

Intern CE, GP

Derde, L.P.G. Mastering hOSpital Antibiotic Resistance in Europe (MOSAR); ICU trial (WP3)

Intern CE

Ermers, M.J.J. Local anti-inflammatory treatment in the prevention of long-term airway morbidity following hospitalisation for respiratory syncytial virus infection: clinical efficacy and immunological correlates.

Extern CE

Gils, E.J.M. van Effect of 2 versus 3 pneumococcal conjugate vaccinations Prevnar ® on nasopharyngeal carriage, transmission and herd immunity; a randomized, controlled study

Joint CE, GP

Groenwold, R.H.H. (see also

Theor. Epi.)

Control and Quantification of confounding by indication in non-randomised studies: Methodological inquiry using an example of vaccine effectiveness

Intern CE, GP

Gourieva, T. Mathematical modelling of MRSA Intern CE

Harimurti, K.H. AsiaLink CE-EBM projectPneumonia in the elderly

Intern CE

Helsper, C.W. Improving diagnosis in Hepatitis C in General Practice

Intern CE, GP

Houben, M.L. Perinatal determinants, including amniotic fluid inflammation and innative immunity, of infant wheeze and RSV lower respiratory infection.

Extern CE


Huijts, S.M. CAPITA, aRCT of 13-valent pneumococcal conjugate vaccine efficacy in prevention of vaccine-serotype pneumococcal CAP en IPD

Intern CE

Jongerden, I.P. Endotracheal suctioning in ICU patients: towards an evidence based guideline

Extern CE, NS

Kurniati, N. AsiaLink CE-EBMHIV infection in children

Intern CE

Looijmans-van den Akker, I.

Evaluation of influenza vaccinations in healthy adults

Intern CE, GP

Meijboom, M.J. Cost-effectiveness (CEA/CUA) of influenza vaccination programmes during interpandemic & pandemic years

Extern CE, GP

Melsen, W.G. Nosocomial infections and mortality Intern CE

Oostdijk, E. SDD and SOD: effects on antibiotic resistance in ICUs

Extern CE

Pijpers, E.J. CHAMP - Changing behaviour of Health care professionals And the general public towards a More Prudent use of anti-microbial agents & Arti-4

Intern GP

Ruskamp, J.M. Upper respiratory tract infections in children; the role of atopy, environmental and life style factors, and genetic polymorphisms in a prospective birth cohort study

Extern CE

Soares da Silva, A.

Air polution study in São Paulo, Brazil Extern CE

Steenhof, M. Risk evaluation of ultrafine (nanosize) ambient particulate matter

Extern CE

Venekamp, R.P. PRET-study: Prednisolone Rhinosinusitis Efficacy Trial

Extern CE, GP

Vugt, S.F. van GRACE (WP 09 + 10) Intern CE, GP

Wassenberg, M.W.M.

Rapid diagnostics of MRSA Extern CE


Willers, S.M. Environmental and life style determinants of childhood asthma and allergy in birth cohort

Extern CE

Zuurbier, M.M.M.

TRAVEL: Transport Related Air pollution, Variance in commuting, Exposure and Lung function

Extern CE



Hak, E.Rovers, M.M.

Respiratory tract infections and prescribing antibiotics in Dutch General Practice; from the second Dutch National Survey on General Practice

Joint GP



Bootsma, M. Mathematical tools in support of infection prevention

Extern CE

Dool, C. van den

Mathematical modelling of infection diseases

Intern CE

Rovers, M.M. Which children with acute otitis media benefit from treatment with antibitics? An individual patients data meta-analysis

Intern CE, GP

Trapman, J.P. Mathematical modelling of infection diseases

Intern CE

Velden, A.W. van der

Implementation of a multiple intervention aimed at optimising prescription of antibiotics for respiratory tract infections, embedded within the new practice accreditation of the Dutch College of General Practitioners; a randomised controlled trial

Joint GP


Verhoeff, M. The effectiveness of treatment with co-trimoxazol in children with chronic otitis media

Extern CE


Cancer



Haars, G. A new look at breast density and breast cancer risk

Intern CE

May, A.M. (see

also Mental Health)

Rehabilitation in cancer: Training and talking? Effects of physical training versus physical training combined with cognitive-behavioural therapy

Intern NS

Vernooij, F. Ovarian cancer treatment in The Netherlands. The effect of care provider on the outcomes of treatment between 1996 and 2003

Extern CE, MTA



Bhoo Pathy, N. Lifestyle and Cancer (AsiaLink CE EBM) Intern CE

Braunius, W. Diagnostic management in patients with head and neck malignancies

Joint CE

Hertogh, E.M. SHAPE/PANACEA Intern CE

Horrée, N. Molecular biology in endometrial carcinogenesis

Extern CE

Kars, M.C. PRESENCE study: The experiences, needs, coping strategies and professional support of parents caring at home for a child with cancer during the palliative phase

Intern NS

Klerkx, W. MR imaging: the efficacy of non-invasive techniques to detect lymph node involvement in gynecologic malignancies

Joint CE

Kok, L. (see also

Theor. Epi)

Early diagnosis of organic bowel diseases in primary care

Intern CE, GP


Lokate, A.J.M. Changes in mammographic density and breast cancer risk (Prospect/EPIC)

Intern CE

Oosterom, M. (see also Mental

Health)

NUCAI: The effect of comprehensive counseling by a specialized nurse on depressive symptoms and quality of life: a randomised study.

Intern NS

Peters, H.G.M. MRI in nonpalpable breast lesions: towards less invasive diagnosis and treatment

Joint CE

Velthuis, M.J. PACT-Study: The influence of physical activity during (breast) cancer chemotherapy on fatigue, fitness and wellbeing

Extern CE

Winden, A.W.J. van

The use of proteomics in the etiologic epidemiology of breast cancer

Intern CE



Elias, S.G. (see

also Theor. Epi.)

Prediction rules for cancer Joint CE

Monninkhof, E.M.

Physical activity and breast cancer risk: a trial in postmenopausal women

Intern CE

Peeters, P.H.M. EPIC-ELDERLY NAH Joint CE



Duijnhoven, F.J.B. van

SOR project: fruit and vegetables in relation to colonrectal cancer in epic

Extern CE

Gamel, C.J. Care for (relatives of) patients with cancer

Intern NS

Gils, C.H. van, Carotenoids, Vitamin C and risk of Breast Cancer in the European Prospective Investigation into Cancer and Nutrition

Joint CE


Huitema, M.C. Effectiveness of oncological follow-up by specialized nurses

Joint NS

May, A.M. Physical activity, nutrition, alcohol, cessation of smoking and eating out of home in relation to obesity

Intern CE

Monninkhof, E.M.

Nutrition, hormones and genes in relation to cancer

Intern CE

Noord, P.A.H. van

DOM project: Diagnostic Investigation Mamma Carcinoma

Intern CE

Noord, P.A.H. van

Trans generational effects of famine Intern CE

Onland-Moret, N.C.

The progesterone synthesis, binding and metabolism pathway and the risk of ovarian cancer

Intern CE

Peeters, P.H.M. (see also

Cardiovascular

diseases)

PROSPECT: European prospective investigation into cancer and nutrition

Intern CE


Cardiovascular

diseases)

EPIC-nl; European Prospective Investigation into Cancer and nutrition-Netherlands

Joint CE


Cardiovascular

diseases and Theor.

Epi.)

Innovation of dietary assessment methods in epidemiological studies and public health (IDAMES)

Extern CE

Peeters, P.H.M. ElectroMagnetischeVelden (EMV) and health

Joint CE

Vrieling, A. SOR-project: fruit and vegetables in relation to pancreatic cancer in EPIC

Extern CE


Mental Health



Aanen, M. Studies on gastroesophageal reflux disease

Extern GP

Appelman, A.P.A. (see also

Cardiovascular

diseases)

Brain atrophy in patients with arterial disease. The SMART-MR study

Joint CE

Bijkerk, C.J. Irritable bowel syndrome in primary care

Intern GP

Knol, M.J. (see

also Cardiovascular

diseases)

Depression and diabetes. Methodological issues in etiologic research

Joint CE

Laan, W. Anti-inflammatory drugs and psychosis Intern CE

May, A.M. (see

also Cancer)

Rehabilitation in cancer: Training and talking? Effects of physical training versus physical training combined with cognitive-behavioural therapy

Intern NS

Velden, A.W. van der

Long-term treatment of gastro-oesophageal reflux disease in primary care

Intern GP, MTA



Boonstra, G. Quiting-study antipsychotic medicine Extern CE

Bosman, M. Prevention of self-harm in psychiatric inpatients

Extern NS

Bozkurt, O. (see

also Cardiovascular

diseases)

UDES project pharmacy Joint CE

Breetveld, E.J. Building blocks of emotion and behaviour in the general population

Extern CE, GP


Clignet, F.G.H.M.

Physical excercise in depressed elderly: The development of a nursing intervention

Extern NS

Dieleman, J.M. (see also Theor. Epi.)

Prophylactic corticosteroids in cardiac surgery

Extern CE

Fluttert, F.A.J. Prevention of violence in forensic psychiatry

Extern NS

Gerritsen, L. (see

also Cardiovascular

diseases)

Psychological stress and depression as risk factors for cognitive decline and Alzheimer’s disease

Intern CE

Grool, A.M. (see

also Cardiovascular

diseases)

Cerebral small-vessel disease and depression in patients with manifest arterial disease: cause or consequence?

Intern CE

Heeg, B.M.S. (see also Theor. Epi.)

Health economic modeling of complex systems; the case of schizophrenia

Extern MTA

Houtjes, W. Development of protocol for the assesment of needs and the application of individualized nursing interventions in depressed elderly

Extern NS

Joosten, G. ‘Deciding Together’: A research into the effectiveness of making a standardised treatment agreement in the addiction treatment care

Extern PH

Knook, L.M.E. Prognosis of children referred for unexplained chronic pain: the PUC (Pediatric Unexplained Chronic pain) study

Extern CE

Knoops, A.J.G. (see also

Cardiovascular

diseases)

The etiology of Alzheimer disease: an innovative hypothesis of depression, vulnerability an biological interaction

Intern CE

Koekkoek, B. The development and testing of a best-practice program for nursing care for chronically depressed patients

Joint NS

Kok, L. CEDAR study: optimal discrimination between organic and functional causes of chronic abdominal pain.

Intern GP


Lee-Kwon, S. Primary Caregivers perception of a long term care facility for their demented elders in Korea and intervening factors of those perceptions

Extern NS

Leeuw, M.G.C. de

Quality of the working alliance in Assertive Community Treatment

Extern NS

Meijer, B Determinants of cognitive decay in the HALE project

Extern CE

Oberndorff Klein Wolthuis, A.

Effectiveness of mebeverine in IBS in primary care

Extern CE, GP

Oosterom, M. (see also Cancer)

NUCAI: The effect of comprehensive counseling by a specialized nurse on depressive symptoms and quality of life: a prospective randomised study.

Intern NS

Pruijssers, A.C. Multidisciplinary diagnostics of anxiety related behavioural disorders in patients with intellectual disabilities

Joint NS

Reincke, C. A clinical prospective cross-sectional diagnostic study on the referral for screening for epilepsy surgery

Extern CE

Smeets, H.M. ARAMIS: analysis of the effectiveness of a PPI reduction programme

Extern GP

Stegenga, B.T. Depression and anxiety in primary care Intern CE, GP

Verkaik, R. Nursing care for depressed elderly with dementia in nursing homes: A multi centre intervention study into the effects of a nursing guideline

Extern NS

Visscher, A.J.M. Prevention of violent behaviour in patients with Acquired Brain Injury.

Extern NS

Zegwaard, M.I. Family care of elder persons with chronic psychiatric problems and difficult behaviour

Extern NS

Zuithoff, N.P.A. (see also Theor. Epi.)

Prediction of depression in primary care Intern CE, GP




Boter, H. The european first episode schizophrenia trial

Extern CE

Hage, S. Self-management strategies for adolescents with violent behaviour

Extern NS

Matthijs, W. Treatment of children with functional disorders or behaviour disorders

Extern MTA

Nuboer, V.S.P. Prevention of suicide in patients with schizophrenia

Extern NS

Peijnenburg, R. The development of a nursing guideline aimed at the reduction of agitated behaviors in patients with dementia

Extern NS

Stel, H.F. van, Swaans, I.J.E.M., Weert-van Oene, G.H. de

Early diagnosis of psychosocial problems in children of 0-4 years in child health centers

Intern PH

Villevoye, D.P.J. Out of school prevention of alcohol and drugs in the European countries

Extern PH

Weert-van Oene, G.H. de

Demand driven mental health care in Utrecht: baseline measurement with respect to care programming in mental health facilities in the region Utrecht

Intern PH


Theoretical Epidemiology and Biostatistics



Eck, J.W.M. van (see also

Cardiovascular

diseases)

Outcomes after pacemaker implantation. Results of the FOLLOWPACE study.

Intern CE

Koopman, L. Pooling of individual patient data from clinical trials. Improvement of analyses of subgroups

Intern CE

Toll, D.B. (see also

Cardiovascular

diseases)

Excluding Deep Vein Thrombosis in primary care: validation, updating, and implementation of a diagnostic rule

Intern CE, GP

Uijl, S.G. Decision-making in temporal lobe epilepsy surgery

Joint CE



Baart, A.M. Prediction of future hemoglobin levels in whole blood and plasma donors

Joint CE, MTA

Bax, L.J. Synthesis of clinical research data: innovations in methods and applications

Intern CE, BS

Bij, S. van der Asbestos and Health: Compensation, Damages and Methodology

Intern CE, MTA

Bijker, J. (see also

Cardiovascular

diseases.)

Intra-operative hypotension and adverse outcome after surgery

Joint CE

Bilecen, S. (see

also Cardiovascular

diseases)

Transufion strategies in cardiac surgery Joint CE

Boonacker, C.W.B. (see also

Infectious Diseases)

Optimizing the transferability and applicability of trial results to other countries

Intern CE


Borkent-Raven, B.A.

The relationship between the cost-effectiveness of blood safety measures and the distribution of patients who receive blood

Intern MTA

Bouwmeester, W.

Prediction models in multilevel data Intern CE

Broekhuizen, B.D.L. (see also


FRESCO study: Diagnostic Strategies for COPD in coughing patients in general practice

Intern CE, GP

Bruins Slot, M.H.E. (see also

Cardiovascular

diseases)

Improving the early diagnosis of myocardial infarction in primary care: the added value of a rapid assay to detect heart-type FABP, a novel marker of myocardial injury - PhD project 2.

Intern CE, GP, MTA

Dieleman, J.M. (see also Mental

Health)

Prophylactic corticosteroids in cardiac surgery

Extern CE

Ettema R.G.A. Prediction and prevention of postoperative complications in elderly undergoing cardiac surgery

Joint CE

Ettema, R.G.A. (see also

Cardiovascular

diseases.)

Improving outcomes of cardiac surgery in elderly patients

Joint CE

Geersing, G.J. (see also

Cardiovascular

diseases.)

Diagnosis of pulmonary embolism in primary care: The AMUSE 2 study

Intern CE, GP

Gondrie, M.J.A. (see also

Cardiovascular

diseases)

PROVIDI: Prognostic value of unrequested information in diagnostic imaging

Intern CE

Graaf-Verhave, R. van der

Justice in research ethics Intern Med. Ethics


Groenwold, R.H.H. (see also


Control and Quantification of confounding by indication in non-randomised studies: Methodological inquiry using an example of vaccine effectiveness

Intern CE, GP

Groot, J.A.H. de Diagnostic research in the absence of a ‘gold’ standard.

Joint CE, BS

Heeg, B.M.S. (see also Mental

Health)

Health economic modeling of complex systems; the case of schizophrenia

Extern MTA

Idris, B.I. (see also

Cardiovascular

diseases.)

Long-term outcomes in cardiac surgery Intern CE

Janssen, M.P. Transfusion Technology Assessment collaboration with Sanquin Blood Supply Foundation

Intern MTA

Kappen, T.H. IMplementation of a Prediction rule in Anesthesia practice to improve Cost-effectiveness of Treatment of postoperative nausea and vomiting: the IMPACT trail

Joint CE

Kok, L. (see also

Cancer)

Early diagnosis of organic bowel diseases in primary care

Intern CE, GP

Pauw, M. Comparison of hospitals using the HSMR

Joint CE

Siccama, R.N. (see also

Cardiovascular

diseases.)

Diagnosis of venous thromoboembolism in the elderly: The VT elderly study

Intern CE, GP

Spoel, O.P. van der (see also

Cardiovascular

diseases)

Improving the early diagnosis of myocardial infarction in primary care: the added value of a rapid assay to detect heart-type FABP, a novel marker of myocardial injury - PhD project 1.

Intern CE, GP, MTA

Svircevic, V. (see

also Cardiovascular

diseases)

Optimal anesthesi techniques in cardiac surgery

Extern CE


Westerhuis, M.E.M.H. (see

also Cardiovascular

diseases)

The cost-effectiveness of ST-analysis of the fetal electrocardiogram as compared to fetal blood sampling for intrapartum monitoring: a randomised controlled trial

Extern CE

Zaane, B. van (see also

Cardiovascular

diseases.)

Diagnostic value of an innovative non-invasive diagnostic to determine the grade of atherosclerosis before sternotmy in patients scheduled for cardiac surgery

Joint CE

Zuithoff, N.P.A. (see also Mental

Health)

Prediction of depression in primary care Intern CE, GP



Elias, S.G. (see

also Cancer)

Prediction rules for cancer Joint CE



Bootsma, M.C.J. Mathematical tools in support of infection prevention

Intern CE

Janssen, K.J.M. Methods for multivariable diagnostic and prognsotic prediction research

Intern CE, MTA

Knol, M.J. Escher project Intern MTA

Koffijberg, H. Cardiovascular prevention at old ages, competing risks, competing costs, frailty and indirect medical costs

Intern CE

Peelen, L.M. (see

also Cardiovascular

diseases)

Theoretical epidemiology in cardiovascular surgery

Intern CE

Peeters, P.H.M. Innovation of dietary assessment methods in epidemiological studies and public health (IDAMES)

Extern CE


Rovers, M.M. Methodological challenges of subgroup analyses in IPD meta-analyses

Intern CE, MTA

Vergouwe, Y. Diagnostic prediction rules: innovative methods to improve their applicability

Intern CE, MTA


Miscellaneous



Dietz, V. Preservation of the uterus in vaginal prolapse surgery: the sacrospinous hysteropexy

Extern CE

Hofhuis, J.G.M. Health related quality of life in critically ill patients

Extern PH



Berk, M.B. Evaluation patient organisations Intern PH

Bernabe, R.B. Ethical and societal dilemmas and prospects in the timely and safe availability of new drugs to individuals

Intern Med. Ethics

Boogaard, J.M.C.

Integrated assessment of health risks of environmental stressors in Europe (INTARESE)

Extern CE

Bruijn, C. de Cognitive behavioural treatment for sub-acute shoulder disorders

Extern CE

Bruns-Neumann, E.E.

Support of parents of premature children

Extern NS

Buiting, H. Evaluation of the law on euthanasia Extern MTA

Dijkstra-Chaves, L.M.

Prevention of pressure ulcers in home care

Extern NS

Eijk, M.M.J. van Rivastigmine for delirium in intensive care patients: a double blind randomised placebo controlled add on trial

Extern CE

Eland-Kok, P. A patient portal for patients with constitutional eczema: feasibility and effectiveness

Extern NS

Engel, M. Palliative care and presence Intern NS


Grul, Y.M. Attention, care and professionalism in care for the elderly

Extern NS

Hoogerduijn, J. Prevention of complications in elderly after hospital admission

Joint NS

Jansen, A.J.M. Differences in health perception between physician and patient in chronically ill children

Extern CE

Jong, S.W. de Population based study on Amyotrophic Lateral Sclerosis Netherlands PAN

Extern CE

Jukema, J.S. Presence in caring relationships Joint NS

Klijn, A. Efficacy of home-uroflowmetry in children with dysfunctional voiding (UFO)

Extern CE

Lemmens, L.C. Strategies to improve preoperative care Joint CE

Luiking-Martin, M-L.

Implementation of evidence based practice

Extern NS

Man-van Ginkel, J.M. de

Post stroke depression Extern CE

Moes, H. Development and testing of innovation/implementation measurement instruments

Intern NS

Piepers, S. Effectiveness of non-invasive artificial respiration at home in patients with ALS

Extern CE

Polet, J.C. Development and validation of a multidisciplinary protocol for with-drawal of artificial breathing on IC units

Joint NS

Rademakers, K. Additional value of MRI in prediction of psychomotorical development in premature children: a cost benefit analysis

Extern CE

Simkens, A.B.M. Evaluation of Physician Assistant trainees in Dutch general practices.

Intern PH

Slieker, M.G. Clinical and genetic predictors of cystic fibrosis phenotype

Intern CE


Staal, I.I.E. Early detection of problems in bringing-up and development of young children: randomized comparison of house calls versus visits to the child health centre at the age of 18 months

Joint PH

Stefansdottir, G.S.

The future postmarketing phase: requirements & opportunities for better safety research

CE

Stuifbergen, M. Changing familiy ties and caretaking of the elderly

Intern MTA

Sutedja, N.A. Environmental and genetic risk factors for amyotrophic lateral sclerosis (ALS)

Extern CE

Thiel, G.J.M.W. van

Evidence-based ethics: reflective equilibrium as a method for combining empirical and ethical elements.

Intern Med. Ethics

Trappenburg, J.C.A.

Disease management in patients with COPD; New strategies to improve self-management skills and early detection of exacerbations

Intern GP, PH

Vallenga, D. Risk management in care of mentally retarded patients with epilepsy

Extern NS



Belkadi, H. Beheer kwaliteitsMonitor voor Centrum Maliebaan

Extern PH

Bos, N. Meetweek Utrecht 2008. Onderzoek naar spoedzorggebruik in de regio Utrecht

Intern PH

Buskens, E. PATMAN: Patient workflow management systems

Intern MTA

Horsman, M.A. project Horsman Extern GP

Linden, B.A. van der

Meaning of American integrated care programs to Dutch chronically ill patients

Extern PH


Rooij, S. Early recognition in elderly hospital patients who are at risk for functional impairments

Extern NS

Urbanus-van Laar, J.J.N.

Evaluation Sylvia Toth Center Intern PH

Veenendaal, L.J. van

Onderzoek naar spoedzorg-gebruik in diverse regio’s in Nederland

Intern PH

Weert-van Oene, G.H. de

IMC benchmarking. Routine Outcome Monitoring of patients in impatient motivation centers in substance dependence care

Extern PH

Weldam, S.D.W. Guideline development to stimulate fluid intake

Extern NS

Wulp, I. van der Comparative study of triage systems in the Netherlands

Intern PH

Zweers-de Groot, J.A.M.

Implementation of care homes Extern NS


Clinical Trial Services Unit / Research Services

Projects 2008 finished

Project Title Activity

ADVANCE Action in Diabetes and Vascular disease; pretax and Diamicron MR Controlled Evaluation

M CT

CLA Possible effects of supplementation with cis-9, 11 conjugated linoleic acid on markers of atherosclerosis

Site/DM CT

DREAM Dutch Randomised Endovascular Aneurysm Management Trial

M/DM CT

FOLLOW-PACE Complications in first year after pacemaker implants

DM Other

Interact Validering van de EPIC-vragenlijst over lichamelijke activiteit (InterAct-studie).

Site Other

Interaction A phase 3, randomized, double-blind trial evaluate the safety, tolerability, and immunogenicity of a 13-valent pneumococcal conjugate vaccine when administered concomitantly with trivalent inactivated influenza vaccine in healty adults 65 years of age or older who are naïve to 23-valent pneumococcal polysaccharide vaccine

Site CTA

JUPITER Justification for the use of statins in primary prevention: an intervention trial evaluating Rosuvastatin

Site CT

MetCon Effect of a disease-specific sip feed on the postprandial glucoseresponse in type 2 diabetic patients

Site CT

Zoster A study to determine the acceptability of the Zostavax vaccine when simultaneously offered with the influenza vaccination in patients of 65 year and above in the general practice

Site/DM Other


067 lipids A multicenter, randomized, double-blind, parallel group, 12-week study to evaluate the efficacy and safety of extended-release (ER) niacin/laropiprant. added to statin versus doubling the dose of statin in patients with primary hypercholesterolemia of mixed dyslipidemia.

Site CT

Projects, ongoing

Project Title Activity

AGEING A pilot study to characterize the effects of ageing on the innate immune response against influenza

Site Other

Altitude A randomized, double-blind, placebo-controlled, parallel-group study to determine whether, in patients with type 2 diabetes at high risk for cardio-vascular and renal events, aliskiren, on top of conventional treatment, reduces cardiovascular and renal morbidity and mortality.

M CT

Ascertain Assesment of everolimus in addition to calcineurin inhibitors reduction in maintenance renal transplant recipients

Site (CIMT only)

CT

AUDITOR Atherosclerosis underlying development assessed by intima-media thickness in patients on Rimonabant

Site CT

CONTRAST The Dutch Convective Transport Study M/DMSite

(CIMT/PWV only)

CT

Diasulin Falen van metformine en sulfonylu-reumderivaat combinatietherapie: stop-pen of doorgaan met een sulfonylu-reumderivaat in combinatie met insu-line glargine bij diabetes type 2 patiën-ten in de huisartspraktijk.

Site/DM CT


EFC6910 A multicenter, double-blind, randomi-zed, 12-month, placebo-controlled study to evaluate the lipid-lowering effect, safety and tolerability of AVE5530 25 mg/day and 50mg/day when added to ongoing stable statin therapy (HMG-CoA reductase inhibitors) in patients with primary hypercholesterolemia

Site CT

FAME Heart-type Fatty Acid binding protein for early Myocardial infarction Exclusion

Site/DM Other

Grace Genomics to combat resistance against antibiotics in community-acquired LRTI in Europe

PM/DM Other

SKI Specifieke Kindhoest Immuniteit K Only re search-

nurse

Other

INFLUENCE65 A randomised observer-blind, active-controlled phase III study to demonstrate the superior efficacy of GSKBiologicals’adjuvanted infleunza candidate vaccine(GSK2186877A) in elderly aged 65 years or above, as comparedto Fluarix®

Site CT

LRGP Utrecht Health Monitoring Study Leidsche Rijn

Site/DM Other

MASTERPLAN Multifactorial Approach and Superior Treatment Efficacy in renal patients with the aid of nurse practitioners

M/DM CT

MINOES Invloed van 2 en 3 Prevenar® vaccinaties in het RVP pneumokokken neusdragerschap, transmissie en ‘herdimmunity’: een gerandomiseerd, gecontroleerd onderzoek.

M/DM CT

NAVIGATOR Efficacy and safety of long term administration of nateglinide and valsartan in the prevention of diabetes and cardiovascular outcome.

Site CT


PERFORM Prevention of cerabrovascular and cardiovascular events if ischaemic origin with te rutroban in patients with a history of ischaemic stroke or transient ischaemic attack

Site (CIMT only)

CT

CAPITA Community Acquired Pneumonia Immunization trial in adults-Pilot studies

Site/DM Other

SHARP Study on Heart And Renal Protection M CT

The Dutch ADDITION Study

As part of the Anglo-Danish-Dutch study of intensive treatment in people with screen detected diabetes in primary care

Site/DM CT

PILL Pilot A randomised placebo-controlled trial of fixed-dose combination medication in people at raised risk of cardiovascular disease

Site CT

PREMIUM Perindopril Amlodipine Regimen versus AT1-Receptor Blocker/thiazide: a comparison of Blood pressure Lowering: Efficacy and Safety. A randomised, double blind, 9 month study of the efficacy and safety of four uptitrated doses of oral fixed combinations of perindopril/amlodipine, including a comparison with uptitrated doses of oral fixed combination of irbesartan and hydrochlorothiazide in mild to moderate hypertension.

Site CT

CT = Clinical Trial

M = Monitoring & Projectmanagement

PM = Projectmanagement

DM = Datamanagement


Data Management

Project/study Description Type

Addition Anglo-Danish-Dutch study on intensive treatment in people with screen detected diabetes in primary care

Other

Amuse II Questionaire on VTE among GPs Other

Arti 4 Study to reduce antibiotic prescriptions in the GP-practice

Other

Benchmarking OK

Reporting tool for operating room efficiency Other

BKO database Database for quality control of research Other

CAP pilot Prestudy Optimizing Diagnosis of Community-Acquired Pneumonia

Other

CHAMP European online case vignette survey among GP’s

Other

CLA Possible effects of suplementation with cis-9,11 conjugated linoleic acid on markers of artherosclerosis

CT

Contrast The Duth convective transport study CT

Dream-On 5 yrs Followup of Dutch Randomized Endovascular Aneurysm Management (DREAM) trial

CT

ECG evaluation Website for evaluation of ECG’s Other

EPIC Panacea Combining data of all EPIC cohorts Cohort

Epic-NL Combining cohorts PROSPECT (JC) and MORGEN (RIVM)

Cohort

EUCCLID Pilot Treatments in diabetics CT

Fame Paneldiagnosis of patients with acute coronary syndrome

Other

FAME2 Evaluation of cardiac damage in GP practice CT

FFQ Online food frequency questionnaire Other

FollowPace2 Follow-up of patients with pacemakers Cohort

Fresco Diagnostical stategies on COPD Other


GGD 18 mnd Comparison of consultation office visit or home visit among children from 18 months at GGD Zeeland

Other

GRACE WP2 Genomics to combat Resistance against Antibiotics in Community acquired LRTI in Europe

Other

Ground Multicenter trial in patients with peripheral vascular pathology

CT

Hemofilie Zweden

Questionnaires for patients with haemophilia in Sweden

Other

HNU GP Network Utrecht, database filled with data from 6 general practices in the region Utrecht

Cohort

ICdelirium Rivastigmine for ICU delirium CT

IJsco IJsselsteinse Screening on Central Obesity Cohort

Impetus Implementation and evaluation of transmural work arrangements Diabete mellitus

CT

IPD Surveillance 2

Surveillance of IPD in children Other

IRIS Internet based hospital care for cardiovascular patients

CT

Isala Cardiac surgery database from ISALA (Zwolle) Other

Kema Processing of KEMA questionnaires Other

Leuko Study on leukemia in children Other

Litra Lithium treatment in ALS patients CT

LRGP Utrecht health monitoring study Leidsche Rijn Cohort

Masterplan Multifactorial approach and superior treatment efficicy in renal patients

CT

Memory The use of Palivizumab on RSV-infection in premature babies

CT

Metabase Online survey about bypass surgery in europe Other

Metabolomics Data collection for metabolomics research in children

Cohort

Meteor Plaque VIC

Measurement of plaque within Meteor participants

CT


Minoes Randomised trial on the influence of 2 or 3 Prevnar vaccinations on transmission, nasal carrying and herdimmunity.

CT

MIS Onderwijs management information database for educations

Other

Mondriaan Platform for collection and integration of care and research data

Cohort

MOSAR WP3 Mastering hOSpital Antimicrobial Resistance (ICU trial)

CT

MOSAR WP4 Mastering hOSpital Antimicrobial Resistance (hospital wards trial)

CT

MOSAR WP5 Mastering hOSpital Antimicrobial Resistance (rehabilitation center trial)

CT

MTX Intolerance

Therapy in patients with Juvenile Idiopathic Arthritis and Methotrexate related side effects

CT

NICU Database for neonates Cohort

NOA Randomised trial on adenotomy in children CT

NUCAI Patients with cancer in head and neck area treated regular compared to use of counseling

CT

Panacea Ezitimibe and simvastin effect on FMD CT

Panter Pancreatitis, Necrosectomie versus minimally invasive step up approach

CT

PedNet European paediatric network for Haemophilia management

Cohort

PINO Randomised trial of a new vaccinations on pneumococcus versus the regular vaccination.

CT

PRET Treatment of rhinosinusitis-like symptoms CT

Prospect Utrecht cohort for lifestyle and cancer and cardiovascular disease

Cohort

Quofun Questionnaires with jaw cancer patients Other

REACTIE Comparison therapy loyalty in different ways of defining risk

Other

Ripag psychiatric cohort in the region Utrecht Cohort


Rodin Research Of Determinants of INhibitor development among Previously untreated patients with haemophilia

Cohort

SKI studie Specific Pertussis Immunity CT

SMART Second Manifestations of ARTerial diseases Cohort

Spiegel Patient safety in general practice Other

Spin UTI Trial on preventive antibiotics in children with spina bifida

CT

SportCor Questionnaire on sudden death at sports Cohort

Stem2 Research on perception of quality of care in diabetes

Other

TIKI IVIG treatment in children with acute ITP CT

Topfit Cardiovascular Fitness program in schizophrenia patients

CT

Van Pelt Study in children with rheumatism Other

Vruchtwater Birth cohort study (a) healthy newborns and (b) premature births and newborns born by caesarean

Cohort

VT_Elderly Study whether existing disission rules on diagnosis of DVT are reliabale in nursing homes

Other

VTE_enquete Questionaire on VTE among nursing home physicians

Other

Whistler The wheezing illnesses study Leidsche Rijn (WHISTLER)

Cohort

Research projects 179 Education 179

Publications 2008

‘Doing research is a good method of education: it

teaches you to design questions, search for answers,

and assess the truth of the answers you get’

Stijntje Bor, Medical Student,

Winner ‘Frits de Waard’ Award 2008

Publications 181

PhD Theses

1 Aanen, M.C. (2008, June 11). Studies on gastroesophageal reflux disease. Utrecht University (139

pag.). Prom./coprom.: prof.dr. A.J.P.M. Smout, dr. A.J. Bredenoord & dr. M.E. Numans.2 Appelman, A.P.A. (2008, May 22). Brain atrophy in patients with arterial disease. The SMART-MR

study. Utrecht University (189 pag.). Prom./coprom.: prof.dr. W.P.T.M. Mali, prof. dr. Y. van der Graaf, dr. M.I. Geerlings & dr.ir. K.L. Vincken.

3 Bax, L. (2008, August 29). Renal function and atherosclerotic renovascular disease. Utrecht University

(160 pag.). Prom./coprom.: prof.dr. W.P.T.M. Mali, prof. dr. Y. van der Graaf & dr. J.J. Beutler Mol.

4 Bijkerk, C.J. (2008, February 26). Irritable bowel syndrome in primary care. Utrecht University (146

pag.). Prom./coprom.: prof.dr. A.W. Hoes, prof.dr. J.A. Knottnerus, dr. N.J. de Wit & J.W.M. Muris.

5 Bont, J. (2008, February 15). Lower respiratory tract infections in the elderly: Prognostic studies in

primary care. Utrecht University (129 pag.). Prom./coprom.: prof.dr. Th.J.M. Verheij, prof.dr. A.W. Hoes & dr. E. Hak.

6 Brandenburg, C.A. (2008, September 4). A transaction cost analysis of Dutch hospital care. Erasmus

University Rotterdam (176 pag.). Prom.: prof.dr. E.G.J. Vosselman, prof.dr. J.P.M. Groenewegen &

prof.dr. A.J.P. Schrijvers.

7 Brouwer, B.G. (2008, May 15). SMART risk factor screening in patients at high vascular risk. Utrecht

University (185 pag.). Prom./coprom.: prof.dr. Y. van der Graaf & dr. F.L.J. Visseren.

8 Dietz, V. (2008, September 2). Preservation of the uterus in vaginal prolapse surgery: the sacrospinous

hysteropexy. Utrecht University (179 pag.) ( Utrecht University). Prom./coprom.: prof. dr. A.P.M.

Heintz, prof.dr. Y. van der Graaf, dr. C.H. van der Vaart & S.E. Schraffordt Koops.

9 Dogan, S. (2008, October 23). Carotid intima-media thickness: studies into methodological aspects.

Utrecht University (185 pag.). Prom./coprom.: prof.dr. D.E. Grobbee & dr. M.L. Bots.

10 Dool, C. van den (2008, October 9). Prevention of Influenza in Health Care Settings: Models and

Observations. Utrecht University (143 pag.). Prom./coprom.: prof.dr. M.J.M. Bonten, dr. E. Hak &

dr.ir. J. Wallinga.

11 Eck, J.W.M. van (2008, May 15). Outcomes after pacemaker implantation : Results of the followpace

study. Utrecht University (152 pag.). Prom./coprom.: prof. dr. N.M. van Hemel, prof.dr. K.G.M. Moons & prof.dr. D.E. Grobbee.

12 El Fakiri, F. (2008, March 14). Prevention of cardiovascular diseases in deprived neighbourhoods.

Erasmus University Rotterdam (141 pag.). Prom./coprom.: M. Berg, prof.dr. A.W. Hoes & dr. M.

Bruynzeels.

13 Gorter, P.M. (2008, March 6). Insulin resistance and adipose tissue in the development of vascular

diseases in high-risk patients. Utrecht University (163 pag.). Prom./coprom.: prof.dr. Y. van der Graaf & dr. F.L.J. Visseren.

14 Haars, G. (2008, September 9). A new look at breast density and breast cancer risk. Utrecht University

(121 pag.). Prom./coprom.: prof.dr. D.E. Grobbee, dr. P.H.M. Peeters, dr. P.A.H. van Noord & dr. C.H. van Gils.

15 Hajer, G.R. (2008, February 21). Vascular risk factors and adipocyte dysfunction in metabolic

syndrome. Utrecht University (175 pag.). Prom./coprom.: prof. dr. E. van der Wall, prof.dr. Y. van der Graaf & dr. F.L.J. Visseren.

16 Halkes, P.H.A. (2008, September 30). ESPRIT (European/Australasian Stroke Prevention in Reversible

Ischaemia Trial) and related studies. Utrecht University (144 pag.). Prom./coprom.: prof.dr. A. Algra

& prof.dr. L.J. Kappelle.

17 Hofhuis, J.G.M. (2008, October 8). Health related quality of life in critically ill patients. Erasmus

University Rotterdam (124 pag.). Prom./coprom.: prof.dr. J. Bakker, prof.dr. A.J.P. Schrijvers, dr. P.E.

Spronk & dr. H. van Stel.


18 Janssen, P.G.H. (2008, September 16). Screening for type 2 diabetes in general practice. Utrecht

University (152 pag.). Prom./coprom.: prof.dr. G.E.H.M. Rutten, dr. R.P. Stolk & dr. K.J. Gorter.

19 Jong, B.M. de (2008, January 24). Lower respiratory tract illness in young children: Predictors of

disease and health care utilization. Utrecht University. Prom./coprom.: prof.dr. Th.J.M. Verheij, prof.

dr. C.K. van der Ent & dr. C.S.P.M. Uiterwaal.20 Kempen, E.E.M.M. van. Transportation noise exposure and children’s health and cognition. Utrecht

University. Prom./coprom.: prof.dr.ir. B. Brunekreef, prof. dr. S.A. Stansfeld, prof.dr. E. Lebret & dr. I.

van Kamp.

21 Knol, M.J. (2008, May 29). Depression and Diabetes - Methodological Issues in Etiologic Research.

Utrecht University (224 pag.). Prom./coprom.: prof.dr. D.E. Grobbee, prof.dr. A.C.G. Egberts, dr. M.I. Geerlings & dr. E.R. Heerdink.

22 Koffijberg, H. (2008, May 29). New decision analytical models for management of intracranial

aneurysms. Utrecht University (220 pag.). Prom./coprom.: prof.dr. G.J.E. Rinkel, prof.dr. B.A. van Hout & dr. E. Buskens.

23 Koopman, L. (2008, January 31). Pooling of Individual patient Data from Clinical Trials:

Improvement of analyses of subgroups. Utrecht University. Prom./coprom.: prof.dr. D.E. Grobbee,

dr. M.M. Rovers & dr. G.J.M.G. van der Heijden.

24 Laan, W. (2008, July 3). Anti-inflammatory drugs and psychosis. Utrecht University (127 pag.).

Prom./coprom.: prof.dr. D.E. Grobbee, prof. dr. R.S. Kahn & dr. H. Burger.

25 Lebrun, C.E.I. (2008, March 6). Determinants of physical aging among healthy Postmenopausal

women and their relation with serum hormone levels. Erasmus Universiteit Rotterdam (172 pag.).

Prom./coprom.: S.W.J. Lamberts, prof.dr. D.E. Grobbee & prof.dr.ir. Y.T. van der Schouw.

26 May-de Groot, A.M. Rehabilitation in cancer: Training and talking? Effects of physical training versus

physical training combined with cognitive-behavioural therapy. Utrecht University. Prom./coprom.:

prof.dr. D.E. Grobbee, J. Passchier & dr. W.J.G. Ros.

27 Molenaar, E.A. (2008, September 30). Obesity Matters : Findings in the Utrecht Health Project and

the Framingham Heart Study. Utrecht University (159 pag.) ( Utrecht University). Prom./coprom.:

prof.dr. D.E. Grobbee, dr. M.E. Numans & E.J.C. van Ameijden.

28 Pruissen, D.M.O. (2008, April 1). Prothrombotic gene variation and cerebral ischaemia of arterial

origin. Utrecht University (151 pag.). Prom./coprom.: prof.dr. A. Algra & dr. L.J. Kapelle.

29 Rutten, A. (2008, February 20). Multi-detector row CT of the heart: methodological evaluation and

application in high-risk patients. Utrecht University (180 pag.). Prom./coprom.: prof.dr. W.M. Prokop

& dr. M.L. Bots.

30 Scholtens, S. (2008, June 12). Breastfeeding, overweight and asthma in Dutch children. The PIAMA

birth cohort study. Utrecht University (149 pag.). Prom./coprom.: prof.dr.ir. B. Brunekreef, J.C.

Seidell & A.H. Wijga.

31 Suarthana, E. (2008, June 6). Predicting occupational lung diseases. Utrecht University (127 pag.).

Prom./coprom.: prof.dr.ir. D.J.J. Heederik, prof.dr. D.E. Grobbee & dr. E. Meijer.

32 Tjang, Y.S. (2008, July 10). Predicting Outcome of Heart Transplantation. Utrecht University (144

pag.). Prom./coprom.: prof.dr. D.E. Grobbee, prof.dr. R. Körfer & dr. G.J.M.G. van der Heijden.

33 Toll, D.B. (2008, April 11). Excluding deep vein thrombosis in primary care: validation, updating, and

implementation of a diagnostic rule. Utrecht University (139 pag.). Prom./coprom.: prof. dr. K.G.M. Moons, prof. dr. A.W. Hoes & dr. R. Oudega.

34 Uijl, S.G. (2008, January 31). Decision-making in temporal lobe epilepsy surgery. Utrecht University.

Prom./coprom.: prof. dr. A.C. van Huffelen, prof. dr. K.G.M. Moons & dr. F.S.S. Leijten.

35 Velden, A.W. van der (2008, October 27). Long-term treatment of gastro-oesophageal reflux disease

in primary care. Utrecht University (106 pag.). Prom./coprom.: prof.dr. D.E. Grobbee & dr. M.E. Numans.

Publications 183

36 Vernooij, F. (2008, March 4). Ovarian cancer treatment in the Netherlands : the effect of care provider

on the outcomes of treatment between 1996-2003. Utrecht University (154 pag.). Prom./coprom.:

prof. dr. A.P.M. Heintz, prof.dr. Y. van der Graaf & dr. P.O. Witteveen.

37 Visscher, S. (2008, September 30). Bayesian network models for the management of ventilator-

associated pneumonia. Utrecht University (177 pag.). Prom./coprom.: prof.dr. M.J.M. Bonten, dr.

P.J.F. Lucas & dr. C.A.M. Schurink.

38 Zafarmand, M.H. (2008, October 21). Genetic risks for cardiovascular diseases. Utrecht University

(188 pag.) (Utrecht). Prom./coprom.: prof.dr. D.E. Grobbee & dr. M.L. Bots.

39 Zuidgeest, M.G.P. (2008, October 8). Children and astma medication. When is that inhaler just a

breath away? Utrecht University. Prom./coprom.: prof.dr. H.G. M. Leufkens, prof.dr.ir. B. Brunekreef, dr. M. Bracke & dr. H.A. Smit.

International Refereed Publications

1 Aanen, M.C., Weusten, B.L.A.M., Numans, M.E., Wit, N.J. de, Samsom, M. & Smout, A.J.P.M. (2008).

Effect of proton-pump inhibitor treatment on symptoms and quality of life in GERD patients

depends on the symptom-reflux association. Journal of Clinical Gastroenterology, 42(5), 441-447.

2 Aanen, M.C., Numans, M.E., Samsom, M. & Smout, A.J.P.M. (2008). Reproducibility of symptom

association analysis in ambulatory reflux monitoring. American Journal of Gastroenterology, 103(9),

2200-2208.

3 Aanen, M.C., Bredenoord, A.J., Samsom, M. & Smout, A.J.P.M. (2008). Reliability of oesophageal pH

recording for the detection of gastro-oesophageal reflux. Scandinavian Journal of Gastroenterology,

43 (12), 1442-1447.

4 Aardweg, M.T.A. van den, Rovers, M.M., Ru, J.A. de, Albers, F.W.J. & Schilder, A.G.M. (2008). A

Systematic Review of Diagnostic Criteria for Acute Mastoiditis in Children. Otology & Neurotology,

29(6), 751-757.

5 Abeelen, A.F. van, Krom, M. de, Hendriks, J.C.J.M., Grobbee, D.E., Adan, R.A.H. & Schouw, Y.T. van der (2008). Variations in the uncoupling protein-3 gene are associated with specific obesity

phenotypes. European Journal of Endocrinology, 158(5), 669-676.

6 Achterberg, S., Kappelle, L.J. & Algra, A. (2008). Prognostic modelling in ischaemic stroke study,

additional value of genetic characteristics. Rationale and design. European Neurology, 59(5), 243-252.

7 Aguilera, I., Sunyer, J., Fernandez-Patier, R., Hoek, G., Aguirre-Alfaro, A., Meliefste, K., Bomboi-

Mingarro, M.T., Nieuwenhuijsen, M.J., Herce-Garraleta, D. & Brunekreef, B. (2008). Estimation of

outdoor NO(x), NO(2), and BTEX exposure in a cohort of pregnant women using land use regression

modeling. Environmental Science and Technology, 42(3), 815-821.

8 Akkerman, A.E., Kuyvenhoven, M.M., Verheij, Th.J.M. & Dijk, L. van (2008). Antibiotics in Dutch

general practice: nationwide electronic GP database and national reimbursement rates.

Pharmacoepidemiology and Drug Safety, 17(4), 378-383.

9 Akmatov, M, Kretzschmar, M.E.E., Kramer, A. & Mikolajczyk, R.T. (2008). Timeliness of vaccination

and its effects on fraction of vaccinated population. Vaccine, 26, 3805-3811.

10 Algra, A., Gijn, J. van, Halkes, P.H.A., Kappelle, L.J. & Koudstaal, P.J. (2008). Interpretation of ESPRIT

in the FASTER trial. Lancet Neurology, 7(3), 198-199.


11 Allen, N.E., Key, T.J., Dossus, L., Rinaldi, S., Cust, A., Lukanova, A., Peeters, P.H.M., Onland-Moret, N.C., Lahmann, P.H., Berrino, F., Panico, S., Larranaga, N., Pera, G., Tormo, M.J., Sanchez, M.J.,

Ramon Quiros, J., Ardanaz, E., Tjonneland, A., Olsen, A., Chang-Claude, J., Linseisen, J., Schulz, M.,

Boeing, H., Lundin, E., Palli, D., Overvad, K., Clavel-Chapelon, F., Boutron-Ruault, M.C., Bingham, S,

Khaw, K.T., Bas Bueno-de-Mesquita, H, Trichopoulou, A., Trichopoulos, D., Naska, A., Tumino, R.,

Riboli, E. & Kaaks, R. (2008). Endogenous sex hormones and endometrial cancer risk in women in

the European Prospective Investigation into Cancer and Nutrition (EPIC). Endocrine-related Cancer,

15(2), 485-497.

12 Anti-HIV Drugs, Study Group, Sabin, C.A., Schneider, M.M.E., Bonten, M.J.M., Borleffs, J.C.C.,

Ellerbroek, P.M., Hoepelman, I.M., Jaspers, C.A.J.J., Schurink, C.A.M. & Lundgren, J.D. (2008).

Changes over time in risk factors for cardiovascular disease and use of lipid-lowering drugs in HIV-

infected individuals and impact on myocardial infarction. Clinical Infectious Diseases, 46(7), 1101-

1110.

13 Antonelli, M., Azoulay, E., Bonten, M.J.M., Chastre, J., Citerio, G., Conti, G., De Backer, D., Lemaire,

F., Gerlach, H., Groeneveld, J., Hedenstierna, G, MacRae, D., Mancebo, J., Maggiore, S.M., Mebazaa,

A., Metnitz, P., Pugin, J., Wernerman, J. & Zhang, H. (2008). Year in review in Intensive Care

Medicine, 2007. I. Experimental studies. Clinical studies: brain injury and neurology, renal failure and

endocrinology. Intensive Care Medicine, 34(2), 229-242.

14 Antonelli, M., Azoulay, E., Bonten, M.J.M., Chastre, J., Citerio, G., De Backer, D., Lemaire, F., Gerlach,

H., Groeneveld, J., Hedenstierna, G, MacRae, D., Mancebo, J., Maggiore, S.M., Mebazaa, A., Metnitz,

P., Pugin, J., Wernerman, J. & Zhang, H. (2008). Year in review in Intensive Care Medicine, 2007. II.

Haemodynamics, pneumonia, infections and sepsis, invasive and non-invasive mechanical ventilation,

acute respiratory distress syndrome. Intensive Care Medicine, 34(3), 405-422.

15 Antonelli, M., Azoulay, E., Bonten, M.J.M., Chastre, J., Citerio, G., Conti, G., De Backer, D., Lemaire,

F., Gerlach, H., Groeneveld, J., Hedenstierna, G, MacRae, D., Mancebo, J., Maggiore, S.M., Mebazaa,

A., Metnitz, P., Pugin, J., Wernerman, J. & Zhang, H. (2008). Year in review in Intensive Care

Medicine, 2007. III. Ethics and legislation, health services research, pharmacology and toxicology,

nutrition and paediatrics. Intensive Care Medicine, 34(4), 598-609.

16 Antova, T., Pattenden, S., Brunekreef, B., Heinrich, J., Rudnai, P., Forastiere, F., Luttmann-Gibson, H.,

Grize, L., Katsnelson, B., Moshammer, H., Nikiforov, B., Slachtova, H., Slotova, K., Zlotkowska, R. &

Fletcher, T. (2008). Exposure to indoor mould and children’s respiratory health in the PATY study.

Journal of Epidemiology and Community Health, 62(8), 708-714.

17 Appelman, A.P.A., Graaf, Y. van der, Vincken, K.L., Tiehuis, A.M., Witkamp, T.D., SMART, Study

Group, Algra, A., Doevendans, P.A.F.M., Eikelboom, B.C., Moll, F.L., Grobbee, D.E., Rutten, G.E.H.M., Kappelle, L.J., Visseren, F.L.J., Mali, W.P.T.M. & Geerlings, M.I. (2008). Total cerebral blood

flow, white matter lesions and brain atrophy: the SMART-MR study. Journal of Cerebral Blood Flow

and Metabolism, 28(3), 633-639.

18 Asch, C.J.J. van, Balemans, W.A.F., Rovers, M.M., Schilder, A.G.M. & Ent, C.K. van der (2008). Atopic

disease and exhaled nitric oxide in an unselected population of young adults. Annals of allergy,

asthma & immunology, 100(1), 59-65.

19 Atsma, F., Bartelink, M.E.L., Schouw, Y.T. van der, Kors, J.A. & Grobbee, D.E. (2008). Elevated blood

pressure and electrocardiographic frontal T axis and spatial QRS-T angle changes in postmenopausal

women. Journal of Electrocardiology, 41(4), 360-364.

20 Atsma, F., Schouw, Y.T. van der, Grobbee, D.E., Hoes, A.W. & Bartelink, M.E.L. (2008). No added

value of age at menopause and the lifetime cumulative number of menstrual cycles for cardiovascular

risk prediction in postmenopausal women. International Journal of Cardiology, 130(2), 190-195.

21 Atsma, F., Bartelink, M.E.L., Grobbee, D.E., Rutten, A., Bots, M.L., Prokop, M. & Schouw, Y.T. van der (2008). Reproductive factors, metabolic factors, and coronary artery calcification in older women.

Menopause, 15(5), 899-904.

Publications 185

22 Avest, P.C. ter, Fischer, K., Mancuso, M.E., Santagostino, E., Yuste, V.J., Berg, H.M. van den, Bom, J.G.

van der & On behalf of, the CANAL Study Group (2008). Risk stratification for inhibitor

development at first treatment for severe hemophilia A: a tool for clinical practice. Journal of

Thrombosis and Haemostasis, 6(12), 2048-2054.

23 Baas, A.F., Janssen, K.J.M., Prinssen, M., Buskens, E. & Blankensteijn, J.D. (2008). The Glasgow

Aneurysm Score as a tool to predict 30-day and 2-year mortality in the patients from the Dutch

Randomized Endovascular Aneurysm Management trial. Journal of Vascular Surgery, 47(2), 277-281.

24 Bartelink, I.H., Bredius, R.G., Ververs, F.F.T., Raphael, M.F., Kesteren, C. van, Bierings, M.B.,

Rademaker, C.M.A., Hartigh, J. den, Uiterwaal, C.S.P.M., Zwaveling, J. & Boelens, J.J. (2008). Once-

Daily Intravenous Busulfan with Therapeutic Drug Monitoring Compared to Conventional Oral

Busulfan Improves Survival and Engraftment in Children Undergoing Allogeneic Stem Cel

Transplantation. Biology of blood and marrow transplantation, 14(1), 88-98.

25 Bax, L., Algra, A., Mali, W.P.T.M., Edlinger, M., Beutler, J.J. & Graaf, Y. van der (2008). Renal function

as a risk indicator for cardiovascular events in 3216 patients with manifest arterial disease [Smart

Study Group]. Atherosclerosis, 200(1), 184-190.

26 Beelen, R., Hoek, G., Brandt, P.A. v.d., Goldbohm, R.A., Fischer, P., Schouten, L.J., Jerrett, M., Hughes,

E., Armstrong, B. & Brunekreef, B. (2008). Long-term effects of traffic-related air pollution on

mortality in a Dutch cohort (NLCS-AIR study). Environmental Health Perspectives, 116(2), 196-202.

27 Beelen, R., Hoek, G., Brandt, P.A. v.d., Goldbohm, R.A., Fischer, P., Schouten, L.J., Armstrong, B. &

Brunekreef, B. (2008). Long-term exposure to traffic-related air pollution and lung cancer risk.

Epidemiology, 19(5), 702-710.

28 Beijnum, J. van, Hanlo, P.W., Fischer, K., Majidpour, M.M., Kortekaas, M.F., Verdaasdonk, R.M. &

Vandertop, W.P. (2008). Laser-assisted endoscopic third ventriculostomy: long-term results in a series

of 202 patients. Neurosurgery, 62(2), 437-443.

29 Benders, M.J., Groenendaal, F., Uiterwaal, C.S.P.M. & Vries, L.S. de (2008). Perinatal arterial stroke in

the preterm infant. Seminars in perinatology, 32(5), 344-349.

30 Berg, B. van den, Grievink, L., Velden, P.G. van der, Yzermans, C.J., Stellato, R.K., Lebret, E. &

Brunekreef, B. (2008). Risk factors for physical symptoms after a disaster: a longitudinal study.

Psychological Medicine, 38(4), 499-510.

31 Bergh, W.M. van den, Water, J.M. van de, Hoff, R.G., Algra, A. & Rinkel, G.J.E. (2008). Calcium

homeostasis during magnesium treatment in aneurysmal subarachnoid hemorrhage. Neurocritical

Care, 8(3), 413-417.

32 Besselink, M.G.H., Santvoort, H.C. van, Buskens, E., Boermeester, M.A., Goor, H. van, Timmerman,

H., Nieuwenhuijs, V.B., Bollen, T.L., Ramshorst, B. van, Witteman, B.J., Rosman, C., Ploeg, R.J., Brink,

M., Schaapherder, A.F., Dejong, C.H. van, Wahab, P.J., Laarhoven, C.J.H.M. van, Harst, E. van der,

Eijck, C.H.J. van, Cuesta, M.A., Akkermans, L.M.A. & Gooszen, H.G. (2008). Probiotic prophylaxis in

predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial. Lancet,

371(9613), 651-659.

33 Besselink, M.G.H., Verwer, T.J., Schoenmaeckers, E.J., Buskens, E., Ridwan, B.U., Visser, M.R.,

Nieuwenhuijs, V.B. & Gooszen, H.G. (2008). Timing of surgical intervention in necrotizing

pancreatitis. Archives of Surgery, 142(12), 1194-1201.

34 Beulens, J.W.J., Kruidhof, J.S., Grobbee, D.E., Chaturvedi, N., Fuller, J.H. & Soedamah-Muthu, S.S

(2008). Alcohol consumption and risk of microvascular complications in type 1 diabetes patients: the

EURODIAB Prospective Complications Study. Diabetologia, 31(10), 2050-2055.

35 Beulens, J.W.J., Rimm, E.B., Hu, F.B., Hendriks H.F. & Mukamal, K.J. (2008). Alcohol consumption,

mediating biomarkers, and risk of type 2 diabetes among middle-aged women. Diabetes Care Oct;31

(10):2050-5.

36 Biesheuvel, C.J., Vergouwe, Y., Oudega, R., Hoes, A.W., Grobbee, D.E. & Moons, K.G.M. (2008).

Advantages of the nested case-control design in diagnostic research. BMC Medical Research

Methodology [E], 8(1), 48.


37 Biesheuvel, C.J., Vergouwe, Y., Steyerberg, E.W., Grobbee, D.E. & Moons, K.G.M. (2008). Polytomous

logistic regression analysis could be applied more often in diagnostic research. Journal of Clinical


38 Bijkerk, C.J., Muris, J.W.M., Knottnerus, J.A., Hoes, A.W. & Wit, N.J. de (2008). Randomised patients

in irritable bowel syndrome research had different disease characteristics compared to eligible an

recruited patients. Journal of Clinical Epidemiology, 61(11), 1176-1181.

39 Bijlsma, J.W.J. & Welsing, P.M.J. (2008). The art of medicine in treating osteoarthritis: I will please.

Annals of the Rheumatic Diseases, 67(12), 1653-1655.

40 Bollen, C.W., Vught, A.J. van & Uiterwaal, C.S.P.M. (2008). High-frequency ventilation is/is not the

optimal physiological approach to ventilate ARDS patients. Journal of Applied Physiology, 104(4),

1238.

41 Bolt, L.L.E., Kalis, A., Derijks, H.J. & Delden, J.J.M. van (2008). Ethical questions in the field of

pharmacogenetics. European Journal of Hospital Pharmacy Practice, 14(1), 30-34.

42 Bont, J., Hoes, A.W., Macfarlane, J.T., Verheij, Th.J.M. & Hak, E. (2008). Predicting death in elderly

patients with community-acquired pneumonia: a prospective validation study reevaluating the CRB-

65 severity assessment tool. Archives of Internal Medicine, 168(13), 1465-1468.

43 Boonacker, C.W.B., Veen, E.L. van der, Wilt, G.J. van der, Schilder, A.G.M. & Rovers, M.M. (2008).

Trimethoprim-Sulfamethoxazole in Children With Chronic Otitis Media: A Randomized Comparison

of Costs and Effects. Otology & Neurotology, 29(7), 961-964.

44 Bor, A.S.E., Rinkel, G.J.E., Adami, J., Koffijberg, H., Ekbom, A., Buskens, E., Blomqvist, P. & Granath,

F. (2008). Risk of subarachnoid haemorrhage according to number of affected relatives: a population

based case–control study. Brain, 131(10), 2662-2665.

45 Bosman, M. & Meijel, B. van (2008). Perspectives of mental health professionals and patients on self-

injury in psychiatry: a literature review. Archives of psychiatric nursing, 22(4), 180-189.

46 Bottema, R.W.B., Reijmerink, N.E., Kerkhof, M., Koppelman, G.H., Stelma, F.F., Gerritsen, J., Thijs, C.,

Brunekreef, B., Schayck, C.P. van & Postma, D.S. (2008). Interleukin 13, CD14, pet and tobacco

smoke influence atopy in three Dutch cohorts: the allergenic study. European Respiratory Journal,

32(3), 593-602.

47 Bozkurt, O., Verschuren, W.M.M., Wieren-de Wijer, B.M.A. van, Knol, M.J., Boer, A. de, Grobbee, D.E., Geerlings, M.I., Heerdink, E.R. & Klungel, O.H. (2008). Genetic variation in the renin-

angiotensin system modifies the beneficial effects of ACE inhibitors on the risk of diabetes mellitus

among hypertensives. Journal of human hypertension, 22, 774-780.

48 Britton, J.A., Khan, A.E., Rohrmann, S., Becker, N., Linseisen, J., Nieters, A., Kaaks, R., Tjonneland, A.,

Halkjaer, J., Severinsen, M.T., Overvad, K., Pischon, T., Boeing, H., Trichopoulou, A., Kalapothaki, V.,

Trichopoulos, D., Mattiello, A., Tagliabue, G., Sacerdote, C., Peeters, P.H.M., Bueno-de-Mesquita,

H.B., Ardanaz, E., Navarro, C., Jakszyn, P., Altzibar, J.M., Hallmans, G., Malmer, B., Berglund, G.,

Manjer, J., Allen, N., Key, T.J., Bingham, S, Besson, H., Ferrari, P., Jenab, M., Boffetta, P., Vineis, P. &

Riboli, E. (2008). Anthropometric characteristics and non-Hodgkin’s lymphoma and multiple

myeloma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).

Haematologica, 93(11), 1666-1677.

49 Bruggen, J.A.R. van, Gorter, K.J., Stolk, R.P., Verhoeven, R.P. & Rutten, G.E.H.M. (2008).

Implementation of locally adapted guidelines on type 2 diabetes. Results of a cluster randomised trial

in primary care. Family Practice, 25(6), 430-437.

50 Bruggen, J.A.R. van, Gorter, K.J., Stolk, R.P. & Rutten, G.E.H.M. (2008). Overall quality of diabetes

care in a defined geographic region: different sides of the same story. British Journal of General

Practice, 58, 39-345.

51 Bruijn, C. de, Bie, R. de, Geraets, J., Goossens, M., Heuvel, W. van den, Heijden, G.J.M.G. van der,

Candel, M. & Dinant, G.J. (2008). Effect of an education and activation programme on functional

limitations and patient-perceived recovery in acute and sub-acute shoulder complaints - A

randomised clinical trial. BMC Musculoskeletal Disorders [E], 8, 112.

Publications 187

52 Bruins Slot, M.H.E., Heijden, G.J.M.G. van der, Rutten, F.H., Spoel, O.P. van der, Mast, E., Bredero,

A.C., Doevendans, P.A., Glatz, J.F.C. & Hoes, A.W. (2008). Heart-type Fatty acid-binding protein in

Acute Myocardial infarction Evaluation (FAME) : background and design of a diagnostic study in

primary care. BMC Cardiovascular Disorders [E], 15(8), 8.

53 Brunekreef, B. & Maynard, R.L. (2008). A note on the 2008 EU standards for particulate matter.

Atmospheric Environment, 42(26), 6425-6430.

54 Brunekreef, B. (2008). Environmental epidemiology and risk assessment. Toxicology Letters, 180(2),

118-122.

55 Bruns, A.H.W., Oosterheert, J.J., Hak, E. & Hoepelman, A.I.M. (2008). Usefulness of consecutive

C-reactive protein measurements in follow-up of severe community-acquired pneumonia. European

Respiratory Journal, 32(3), 726-732.

56 Brussel, M. van, Takken, T., Uiterwaal, C.S.P.M., Pruijs, J.E.H., Net, J. van der, Helders, P.J.M. &

Engelbert, R.H.H. (2008). Physical Training in Children with Osteogenesis Imperfecta. The Journal of

Pediatrics, 152(1), 111-116.el.

57 Buiting, H.M., Rietjens, J.A.C., Onwuteaka-Philipsen, B.D., Maas, P.J. van der, Delden, J.J.M. van &

Heide, A. van der (2008). A comparison of physicians’ end-of-life decision-making for non-western

migrants and Dutch natives in the Netherlands. European Journal of Public Health, 18(6), 681-687.

58 Buiting, H.M., Gevers, J.K.M., Rietjens, J.A.C., Onwuteaka-Philipsen, B.D., Maas, P.J. van der, Heide,

A. van der & Delden, J.J.M. van (2008). Dutch criteria of due care for physician-assisted dying in

medical practice. A physician perspective. Journal of Medical Ethics, 34(9), e12.

59 Capella, G., Pera, G., Sala, N., Agudo, A., Rico, F., Giudicce, G. del, Plebani, M., Palli, D., Boeing, H.,

Bueno-de-Mesquita, H.B., Carneiro, F., Berrino, F., Vineis, P., Tumino, R., Panico, S., Berglund, G.,

Siman, H., Nyren, O., Hallmans, G., Martinez, C., Dorronsoro, M., Barricarte, A., Navarro, C., Quiros,

J.R., Allen, N., Key, T.J., Bingham, S., Caldas, C., Linseisen, J., Nagel, G., Overvad, K., Tjonneland, A.,

Boshuizen, H.C., Peeters, P.H.M., Numans, M.E., Clavel-Chapelon, F., Trichopoulou, A., Lund, E.,

Jenab, M., Kaaks, R., Riboli, E. & Gonzalez, C.A. (2008). DNA repair polymorphisms and the risk of

stomach adenocarcinoma and severe chronic gastritis in the EPIC-EURGAST study. International

journal of epidemiology, 37(6), 1316-1325.

60 Chavez-MacGregor, M., Gils, C.H. van, Schouw, Y.T. van der, Monninkhof, E.M., Noord, P.A.H. van

& Peeters, P.H.M. (2008). Lifetime cumulative number of menstrual cycles and serum sex hormone

levels in postmenopausal women. Breast Cancer Research and Treatment, 108(1), 101-112.

61 Chen, C.M., Gehring, U., Wickman, M., Hoek, G., Giovannangelo, M., Nordling, E., Wijga, A., Jongste,

J.C. de, Pershagen, G., Almqvist, C., Kerkhof, M., Bellander, T., Wichmann, H.E., Brunekreef, B. &

Heinrich, J. (2008). Domestic cat allergen and allergic sensitisation in young children. International

Journal of Hygiene and Environmental Health, 211(3-4), 337-344.

62 Cleveringa, F.G.W., Gorter, K.J., Donk, M. van den & Rutten, G.E.H.M. (2008). Combined task

delegation, computerized decision support and feedback information improve cardiovascular risk for

type 2 diabetes patients. A cluster randomized trial in primary care. Diabetes Care, 31(12), 2273-

2275.

63 Coenen, S., Ferech, M., Haaijer-Ruskamp, F.M., Butler, C.C., Vander Stichele, R.H., Verheij, Th.J.M., Monnet, D.L., Little, P. & Goossens, H.H.L.M. (2008). European Surveillance of Antimicrobial

Consumption (ESAC): Kwaliteitsindicatoren voor het antibioticagebruik in de ambulante praktijk.

Huisarts nu, 37(9), 456-462.

64 Cohen, J., Delden, J.J.M. van, Mortier, F., Löfmark, R., Norup, M., Cartwright, C., Faisst, K., Canova,

C., Onwuteaka-Philipsen, B.D. & Bilsen, J. (2008). Influence of physicians’ life stances on attitudes to

end-of-life decisions and actual end-of-life decision-making in six countries. Journal of Medical

Ethics, 34, 247-253.

65 Colvin, B.T., Astermark, J., Fischer, K., Gringeri, A., Lassila, R., Schramm, W., Thomas, A. & Ingerslev,

J. (2008). European principles of haemophilia care. Haemophilia, 14(2), 361-374.


66 Compter, A., Worp, H.B. van der, Schonewille, W.J., Vos, J.A., Algra, A., Lo, T.H., Mali, W.P.T.M., Moll,

F.L. & Kappelle, L.J. (2008). VAST: Vertebral Artery Stenting Trial. Protocol for a randomised safety

and feasibility trial. Trials [E], 9(1), 65-65.

67 Cox, D.G., Bretsky, P., Kraft, P., Pharoah, P., Albanes, D., Altshuler, D., Amiano, P., Berglund, G.,

Boeing, H., Buring, J.E., Burtt, N.P., Calle, E.E., Canzian, F., Chanock, S., Clavel-Chapelon, F., Colditz,

G., Feigelson, H.S., Haiman, C.A., Hankinson, S.E., Hirschhorn, J.N., Henderson, B.E., Hoover, R.,

Hunter, D.J., Kaaks, R., Kolonel, L.N., LeMarchand, L., Lund, E., Palli, D., Peeters, P.H.M., Pike, M.C.,

Riboli, E., Stram, D.O., Thun, M.J., Tjonneland, A., Travis, R.C., Trichopoulos, D. & Yeager, M. (2008).

Haplotypes of the estrogen receptor beta gene and breast cancer risk. International Journal of Cancer,

122(2), 387-392.

68 Crusius, J.B.A., Canzian, F., Capella, G., Peña, A.S., Pera, G., Sala, N., Agudo, A, Rico, F., Giudice, G.

del, Palli, D., Plebani, M., Boeing, H., Bueno-de-Mesquita, H.B., Carneiro, F., Pala, V., Save, V., Vineis,

P., Tumino, R., Panico, S., Berglund, G., Manjer, J., Stenling, R., Hallmans, G., Martinez, C.,

Dorronsoro, M., Barricarte, A., Navarro, C., Quiros, J.R., Allen, N., Key, T.J., Bingham, S., Caldas, C.,

Linseisen, J., Kaaks, R., Overvad, K., Tjonneland, A., Büchner, F.C., Peeters, P.H., Numans, M.E., Clavel-Chapelon, F., Trichopoulos, A., Lund, E., Jenab, M., Rinaldi, S., Ferrari, P., Riboli, E. &

Gonzalez, C.A. (2008). Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach

in the European prospective investigation into cancer and nutrition (EPIC-EURGAST). Annals of

Oncology, 19(11), 1894-1902.

69 Cummings, S.R., Ettinger, B., Delmas, P.D., Kenemans, P., Stathopoulos, V., Verweij, P., Mol-Arts, M.,

Kloosterboer, L., Mosca, L., Christiansen, C., Bilezikian, J.P., Kerzberg, E.M., Johnson, S., Zanchetta, J.,

Grobbee, D.E., Diest, P.J. van, Seifert, W., Eastell, R. & LIFT Trial, Invest. (2008). The effects of

tibolone in older postmenopausal women [for the LIFT Trial Investigators]. New England Journal of

Medicine, 359, 697-708.

70 D.A.D., Study Group, Sabin, C.A., Schneider, M.M.E., Bonten, M.J.M., Borleffs, J.C.C., Ellerbroek,

P.M., Hoepelman, I.M., Jaspers, C.A.J.J., Schurink, C.A.M. & Lundgren, J.D. (2008). Use of nucleoside

reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients enrolled in

the D:A:D study: a multi-cohort collaboration. Lancet, 371(9622), 1417-1426.

71 Dalmeijer, G.W., Olthof, M., Verhoef, P., Bots, M.L. & Schouw, Y.T. van der (2008). Prospective study

on dietary intakes of folate, betaine, and choline and cardiovascular disease risk in women. European

Journal of Clinical Nutrition, 62(3), 386-394.

72 Davis, S.A., Trapman, J.P., Leirs, H., Begon, M. & Heesterbeek, J.A.P. (2008). The abundance threshold

for plague as a critical percolation phenomenon. Nature, 454(7204), 634-637.

73 Delden, J.J.M. van, Ashcroft, R., Dawson, A., Marckmann, G., Upshur, R. & Verweij, M.F. (2008). The

ethics of mandatory vaccination against influenza for health care workers. Vaccine, 26(44), 5562-5566.

74 Deurzen, C.H.M. van, Boer, M. de, Monninkhof, E.M., Bult, P., Wall, E. van der, Tjan-Heijnen, V.C. &

Diest, P.J. van (2008). Non-sentinel lymph node metastases associated with isolated breast cancer cells

in the sentinel node. Journal of the National Cancer Institute, 100(22), 1574-1580.

75 Dickstein, K., Cohen-Solal, A., Filippatos, G., McMurray, J.J., Ponikowski, P., Poole-Wilson, P.A.,

Strömberg, A., Veldhuisen, D.J. van, Atar, D., Hoes, A.W., Keren, A., Mebazaa, A., Nieminen, M.,

Priori, S.G., Swedberg, K, Vahanian, A., Camm, J., Caterina, R. De, Dean, V., Funck-Brentano, C.,

Hellemans, I., Kristensen, S.D., McGregor, K., Sechtem, U., Silber, S., Tendera, M., Widimsky, P. &

Zamorano, J.L. (2008). ESC guidelines for the diagnosis and treatment of acute and chronic heart

failure 2008: the Task Force for the diagnosis and treatment of acute and chronic heart failure 2008 of

the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of

the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM).

European Heart Journal, 29(19), 2388-2442.

Publications 189



Priori, S.G., Swedberg, K, Vahanian, A., Camm, A.J., Caterina, R. De, Dean, V., Funck-Brentano, C.,

Hellemans, I.M., Kristensen, S.D., McGregor, K., Sechtem, U., Silber, S., Tendera, M., Widimsky, P.,

Zamorano, J.L., Tendera, M., Auricchio, A., Bax, J., Böhm, M., Corrà, U., Bella, P. della, Elliott, P.M,

Follath, F., Gheorghiade, M., Hasin, Y., Hernborg, A., Jaarsma, T., Komajda, M., Kornowski, R.,

Piepoli, M., Prendergast, B., Tavazzi, L., Vachiery, J.L., Verheugt, F.W.A., Zarnorano, J.L. & Zannad, F.

(2008). ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the

Task Force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European

Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC

(HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). European Journal

of Heart Failure, 10(10), 933-989.

77 Dijk, D. van, Moons, K.G.M., Nathoe, H.M., Aarnhem, E.E.H.L. van, Borst, C., Keizer, A.M.A.,

Kalkman, C.J. & Hijman, R. (2008). Cognitive Outcomes Five Years After Not Undergoing Coronary

Artery Bypass Graft Surgery. Annals of Thoracic Surgery, 85(1), 60-64.

78 Dijkema, M.B.A., Zee, S.C. van der, Brunekreef, B. & Strien, R.T. van (2008). Air quality effects of an

urban highway speed limit reduction. Atmospheric Environment, 42(40), 9098-9105.

79 Dijkema, T., Terhaard, C.H.J., Roesink, J.M., Braam, P.M., Gils, C.H. van, Moerland, M.A. &

Raaijmakers, C.P.J. (2008). Large Cohort Dose-Volume Response Analysis of Parotid Gland Function

After Radiotherapy: Intensity-Modulated VERSUS Conventional Radiotherapy. International Journal

of Radiation Oncology Biology Physics, 72(4), 1101-1109.

80 Disseldorp, J. van, Faddy, M.J., Themmen, A.P.N., Jong, F.H. de, Peeters, P.H.M., Schouw, Y.T. van der

& Broekmans, F.J.M. (2008). Relationship of serum antimüllerian hormone concentration to age at

menopause. Journal of Clinical Endocrinology and Metabolism, 93(6), 2129-2134.

81 Disseldorp, J. van, Broekmans, F.J.M., Peeters, P.H., Fauser, B.C.J.M. & Schouw, Y.T. van der (2008).

The association between vascular function-related genes and age at natural menopause. Menopause,

15(3), 511-516.

82 Dool, C. van den, Strien, A.M. van, Akker, I.L. den, Bonten, M.J.M., Sanders, E.A.M. & Hak, E. (2008).

Attitude of Dutch hospital personnel towards influenza vaccination. Vaccine, 26(10), 1297-1302.

83 Dool, C. van den, Hak, E., Wallinga, J., Loon, A.M. van, Lammers, J.W.J. & Bonten, M.J.M. (2008).

Symptoms of influenza virus infection in hospitalized patients. Infection control and hospital

epidemiology, 29(4), 314-319.

84 Dool, C. van den, Bonten, M.J.M., Hak, E., Heijne, J.C. & Wallinga, J. (2008). The effects of influenza

vaccination of health care workers in nursing homes: insights from a mathematical model. PLoS

medicine, 5(10), e200.

85 Dorhout Mees, S.M., Bergh, W.M. van den, Algra, A. & Rinkel, G.J.E. (2008). Antiplatelet therapy in

aneurysmal subarachnoid hemorrhage. Stroke, 39, 2186-2187.

86 Dorhout Mees, S.M., Rinkel, G.J.E., Feigin, V.L., Algra, A., Bergh, W.M. van den, Vermeulen, M. &

Gijn, J. van (2008). Calcium antagonists for aneurysmal subarachnoid hemorrhage. Stroke, 39(2),

514-515.

87 Dorhout Mees, S.M., Algra, A. & Mash-II, Study Group (2008). Magnesium in aneurysmal

subarachnoid hemorrhage (MASH II) phase III clinical trial MASH-II study group. International

Journal of Stroke, 3(1), 63-65.


88 Dossus, L., McKay, J.D., Canzian, F., Wilkening, S., Rinaldi, S., Biessy, C., Olsen, A., Tjonneland, A.,

Jakobsen, M.U., Overvad, K., Clavel-Chapelon, F., Boutron-Ruault, M.C., Fournier, A., Linseisen, J.,

Lukanova, A., Boeing, H., Fisher, E., Trichopoulou, A., Georgila, C., Trichopoulos, D., Palli, D., Krogh,

V., Tumino, R., Vineis, P., Quiros, J.R., Sala, N., Martinez-Garcia, C., Dorronsoro, M., Chirlaque, M.D.,

Barricarte, A., Duijnhoven, F.J.B van, Bueno-de-Mesquita, H.B., Gils, C.H. van, Peeters, P.H.M., Hallmans, G., Lenner, P., Bingham, S, Khaw, K.T., Key, T.J., Travis, R.C., Ferrari, P., Jenab, M., Riboli, E.

& Kaaks, R. (2008). Polymorphisms of genes coding for ghrelin and its receptor in relation to

anthropometry, circulating levels of IGF-I and IGFBP-3, and breast cancer risk: a case-control study

nested within the European Prospective Investigation into Cancer and Nutrition (EPIC).

Carcinogenesis, 29(7), 1360-1366.

89 Dungen, C. van den, Hoeymans, N., Gijsen, R., Akker, M. van den, Boesten, J., Smeets, H.M., Veen,

W.J. van der, Verheij, R., Waal, M. de, Schellevis, F. & Westert, G.P. (2008). What factors explain the

differences in morbidity estimations among general practice registration networks in the

Netherlands? A First analysis. European Journal of General Practice, 14(suppl 1), 53-62.

90 Eck, J.W.M. van, Hemel, N.M. van, Kelder, J.C., Bos, A.A. van den, Taks, W., Grobbee, D.E. & Moons, K.G.M. (2008). Poor health-related quality of life of patients with indication for chronic cardiac

pacemaker therapy. PACE-Pacing and Clinical Electrophysiology, 31(4), 480-486.

91 Eck, J.W.M. van, Hemel, N.M. van, Bos, A. van den, Taks, W., Grobbee, D.E. & Moons, K.G.M. (2008). Predictors of improved quality of life 1 year after pacemaker implantation. American Heart

Journal, 156(3), 491-497.

92 Eck, J.W.M. van, Hemel, N.M. van, Voogt, W.G. de, Meeder, M., Spierenburg, H.A., Crommentuyn,

H., Keijzer, R., Grobbee, D.E. & Moons, K.G.M. (2008). Routine follow-up after pacemaker

implantation: frequency, pacemaker programming and professionals in charge. Europace, 10(7), 832-

837.

93 Ege, M.J., Herzum, I., Buchele, G., Krauss-Etschmann, S., Lauener, R.P., Roponen, M., Hyvarinen, A.,

Vuitton, D.A., Riedler, J., Brunekreef, B., Dalphin, J.C., Braun-Fahrlander, C., Pekkanen, J., Renz, H. &

von Mutius, E. (2008). Prenatal exposure to a farm environment modifies atopic sensitization at birth.

Journal of Allergy and Clinical Immunology, 122(2), 407-412.e1-4.

94 Ege, M.J., Herzum, I., Buchele, G., Krauss-Etschmann, S., Lauener, R.P., Bitter, S., Roponen, M.,

Remes, S., Vuitton, D.A., Riedler, J., Brunekreef, B., Dalphin, J.C., Braun-Fahrlander, C., Pekkanen, J.,

Renz, H. & von Mutius, E. (2008). Specific IgE to allergens in cord blood is associated with maternal

immunity to Toxoplasma gondii and rubella virus. Allergy, 63(11), 1505-1511.

95 Ekkelenkamp, M.B., Bruggen, T. van der, Vijver, D.A.M.C. van de, Wolfs, T.F.W. & Bonten, M.J.M. (2008). Bacteremic Complications of Intravascular Catheters Colonized with Staphylococcus aureus.

Clinical Infectious Diseases, 46, 114-118.

96 El Fakiri, F., Bruijnzeels, M.A., Foets, M.M. & Hoes, A.W. (2008). Different distribution of

cardiovascular risk factors according to ethnicity: a study in a high risk population. Journal of

Immigrant and Minority Health, 10(6), 559-565.

97 El Fakiri, F., Bruijnzeels, M.A., Uitewaal, P.J.M., Frenken, R.A., Berg, M. & Hoes, A.W. (2008).

Intensified preventive care to reduce cardiovascular risk in healthcare centres located in deprived

neighbourhoods: a randomized controlled trial. European Journal of Cardiovascular Prevention and

Rehabilitation, 15(4), 488-493.

98 El Fakiri, F., Hoes, A.W., Uitewaal, P.J., Frenken, R.A. & Bruijnzeels, M.A. (2008). Process evaluation of

an intensified preventive intervention to reduce cardiovascular risk in general practices in deprived

neighbourhoods. European Journal of Cardiovascular Nursing, 7(4), 296-302.

99 Elden, L.J.R. van, Sachs, A.P.E., Loon, A.M. van, Haarman, M., Vijver, D.A.M.C. van de, Kimman,

T.G., Zuithoff, P., Schipper, P.J., Verheij, Th.J.M. & Nijhuis, M. (2008). Enhanced severity of virus

associated lower respiratory tract disease in asthma patients may not be associated with delayed viral

clearance and increased viral load in the upper respiratory tra. Journal of Clinical Virology, 41(2),

116-121.

Publications 191

100 Eller, E., Roll, S., Chen, C.M., Herbarth, O., Wichmann, H.E., von Berg, A., Kramer, U., Mommers, M.,

Thijs, C., Wijga, A., Brunekreef, B., Fantini, M.P., Bravi, F., Forastiere, F., Porta, D., Sunyer, J., Torrent,

M., Host, A., Halken, S., Lodrup Carlsen, K.C., Carlsen, K.H., Wickman, M., Kull, I., Wahn, U.,

Willich, S.N., Lau, S., Keil, T. & Heinrich, J. (2008). Meta-analysis of determinants for pet ownership

in 12 European birth cohorts on asthma and allergies: a GA2LEN initiative. Allergy, 63(11), 1491-

1498.

101 Emmelot-Vonk, M.H., Verhaar, H.J.J., Nakhai Pour, H.R., Aleman, A., Lock, M.T.W.T., Bosch,

J.L.H.R., Grobbee, D.E. & Schouw, Y.T. van der (2008). Effect of testosterone supplementation on

functional mobility, cognition, and other parameters in older men: a randomized controlled trial.

JAMA - The Journal of The American Medical Association, 299(1), 39-52.

102 Essen, G.A. van (2008). Influenza vaccination of healthcare workers, oseltamivir resistance and

prepandemic vaccination. Expert Review of Respiratory Medicine, 2, 703-705.

103 Esser, S. van, Hobbelink, M.G.G., Peeters, P.H.M., Buskens, E., Ploeg, I.M. van der, Mali, W.P.T.M.,

Borel Rinkes, I.H.M. & Hillegersberg, R. van (2008). The efficacy of ‘Radio guided Occult Lesion

Localization’ (ROLL) versus ‘Wire-guided Localization’ (WGL) in breast conserving surgery for non-

palpable breast cancer: a randomized clinical trial - ROLL study. BMC Surgery [E], 8(1), 9-9.

104 Fioole, B., Haas, R.J. de, Wicherts, D.A., Elias, S.G., Scheffers, J.M., Hillegersberg, R. van, Leeuwen,

M.S. van & Borel Rinkes, I.H.M. (2008). Additional value of contrast enhanced intraoperative

ultrasound for colorectal liver metastases. European Journal of Radiology, 67(1), 169-176.

105 Fischer, K. (2008). Can we consider discontinuing primary prophylaxis in adults with severe

haemophilia? Haemophilia, 14(S4), 10-10.

106 Fischer, K., Valentino, L., Ljungs, R. & Blanchette, V. (2008). Prophylaxis for severe haemophilia:

clinical challenges in the absence as well as in the presence of inhibitors. Haemophilia, 14(S3), 196-

201.

107 Flohr, C., Weiland, S.K., Weinmayr, G., Bjorksten, B., Braback, L., Brunekreef, B., Buchele, G.,

Clausen, M., Cookson, W.O., von Mutius, E., Strachan, D.P. & Williams, H.C. (2008). The role of

atopic sensitization in flexural eczema: findings from the International Study of Asthma and Allergies

in Childhood Phase Two. Journal of Allergy and Clinical Immunology, 121(1), 141-147.e4.

108 Fluttert, F.A.J., Meijel, B.K.G. van, Webster, C., Nijman, H., Bartels, A. & Grypdonck, M.H.F. (2008).

Risk management by early recognition of warning signs in patients in forensic psychiatric care.

Archives of psychiatric nursing, 22(4), 208-216.

109 Fonville, S., Worp, H.B. van der, Maat, P., Aldenhoven, M., Algra, A. & Gijn, J. van (2008). Accuracy

and inter-observer variation in the classification of dysarthria from speech recordings. Journal of

Neurology, 255, 1545-1548.

110 Furnee, E.J.B., Draaisma, W.A., Broeders, I.A.M.J., Smout, A.J.P.M., Vlek, A.L.M. & Gooszen, H.G.

(2008). Predictors of symptomatic and objective outcomes after surgical reintervention for failed

antireflux surgery. British Journal of Surgery, 95(11), 1369-1374.

111 Gast, G.C.M., Grobbee, D.E., Pop, V.J., Keyzer, J.J., Wijnands-van Gent, C.J., Samsioe, G., Nilsson, P. &

Schouw, Y.T. van der (2008). Menopausal complaints are associated with cardiovascular risk factors.

Hypertension, 51(6), 1492-1498.

112 Geerlings, M.I., Heijer, T. den, Koudstaal, P.J., Hofman, A. & Breteler, M.M. (2008). History of

depression, depressive symptoms, and medial temporal lobe atrophy and the risk of Alzheimer

disease. Neurology, 70(15), 1258-1264.

113 Geerts, C.C., Bots, M.L., Grobbee, D.E. & Uiterwaal, C.S.P.M. (2008). Parental smoking and vascular

damage in young adult offspring: is early life exposure critical? The atherosclerosis risk in young

adults study. Arteriosclerosis, Thrombosis and Vascular Biology, 28(12), 2296-2302.


114 Gehring, U., Strikwold, M., Schram-Bijkerk, D., Weinmayr, G., Genuneit, J., Nagel, G., Wickens, K.,

Siebers, R., Crane, J., Doekes, G., Di Domenicantonio, R., Nilsson, L., Priftanji, A., Sandin, A., El-

Sharif, N., Strachan, D., Hage, M. van, von Mutius, E. & Brunekreef, B. (2008). Asthma and allergic

symptoms in relation to house dust endotoxin: Phase Two of the International Study on Asthma and

Allergies in Childhood (ISAAC II). Clinical and Experimental Allergy, 38(12), 1911-1920.

115 Gehring, U., Spithoven, J., Schmid, S., Bitter, S., Braun-Fahrlander, C., Dalphin, J.C., Hyvarinen, A.,

Pekkanen, J., Riedler, J., Weiland, S.K., Buchele, G., von Mutius, E., Vuitton, D.A. & Brunekreef, B. (2008). Endotoxin levels in cow’s milk samples from farming and non-farming families - the

PASTURE study. Environment International, 34(8), 1132-1136.

116 Gent, R. van, Meer, G. de, Rovers, M.M., Kimpen, J.L.L., Ent, C.K. van der & Essen, L.E van (2008).

Adherence to follow-up recommendations in asthma. Archives of Disease in Childhood, 93(3), 236-

238.

117 Gestel, J.P.J. van, Bollen, C.W., Tweel, I. van der, Boelens, J.J. & Vught, A.J. van (2008). Intensive care

unit mortality trends in children after hematopoietic stem cell transplantation: a meta-regression

analysis. Critical Care Medicine, 36(10), 2898-2904.

118 Goessens, B.M.B., Visseren, F.L.J., Nooijer, J. de, Borne, H.W. van den, Algra, A., Wierdsma, J. &

Graaf, Y. van der (2008). A pilot-study to identify the feasebility of an internet-based coaching

programme for changing to vascular risk profile of high-risk patients [Smart Study Group]. Patient

Education and Counseling, 73(1), 67-72.

119 Gorter, P.M., Visseren, F.L.J., Moll, F.L., Graaf, Y. van der & SMART, Study Group (2008). Intra-

abdominal fat and metabolic syndrome are associated with larger infrarenal aortic diameters in

patients with clinically evident arterial disease. Journal of Vascular Surgery, 48(1), 114-120.

120 Gorter, P.M., Lindert, A.S.R. van, Vos, A.M. de, Meijs, M.F.L., Graaf, Y. van der, Doevendans, P.A.F.M.,

Prokop, W.M. & Visseren, F.L.J. (2008). Quantification of epicardial and peri-coronary fat using

cardiac computed tomography; reproducibility and relation with obesity and metabolic syndrome in

patients suspected of coronary artery disease. Atherosclerosis, 197(2), 896-903.

121 Gorter, P.M., Vos, A.M. de, Graaf, Y. van der, Stella, P.R., Doevendans, P.A.F.M., Meijs, M.F.L., Prokop,

W.M. & Visseren, F.L.J. (2008). Relation of epicardial and pericoronary fat to coronary atherosclerosis

and coronary artery calcium in patients undergoing coronary angiography. American Journal of

Cardiology, 102(4), 380-385.

122 Graaf, Y. van der (2008). Aggressive vascular surgery in asymptomatic patients is a bad idea. British

Journal of Surgery, 95(6), 671-673.

123 Graham, I.A., Atar, D., Borch-Johnsen, K., Boysen, G., Burell, G., Cifkova, R., Dallongeville, J., Backer,

G. de, Ebrahim, S., Gjelsvik, B., Herrmann-Lingen, C., Hoes, A.W., Humphries, S.E., Knapton, M.,

Perk, J., Priori, S.G., Pyorala, K., Reiner, Z., Ruilope, L, Sans-Menendez, S., Scholte op Reimer, W.,

Weissberg, P., Wood, G.D., Yarnell, J. & Zamorano, J.L. (2008). European guidelines on cardiovascular

disease prevention in clinical practice: executive summary. Revista Espanola de Cardiologia, 61(1), 82.

e1-82.e49.

124 Graham, I.A., Atar, D., Borch-Johnsen, K., Boysen, G., Burell, G., Cifkova, R., Dallongeville, J., Backer,

G. de, Ebrahim, S., Gjelsvik, B., Herrmann-Lingen, C., Hoes, A.W., Humphries, S.E., Knapton, M.,

Perk, J., Priori, S.G., Pyorala, K., Reiner, Z., Ruilope, L, Sans-Menendez, S., Scholte op Reimer, W.,

Weissberg, P., Wood, G.D., Yarnell, J. & Zamorano, J.L. (2008). European practice guidelines on

prevention of cardiovascular diseases: executive summary [Linee guida europee sulla prevenzione

delle malattie cardiovascolari nella pratica clinica: riassunto esecutivo.]. Giornale Italiano di

Cardiologia, 9, 11-59.

125 Greving, J.P., Buskens, E., Koffijberg, H. & Algra, A. (2008). Cost-effectiveness of aspirin treatment

in the primary prevention of cardiovascular disease events in subgroups based on age, gender, and

varying cardiovascular risk. Circulation, 117(22), 2875-2883.

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126 Groenwold, R.H.H., Deursen, A.M. van, Hoes, A.W. & Hak, E. (2008). Poor quality of reporting

confounding bias in observational intervention studies: a systematic review. Annals of epidemiology,

18(10), 746-751.

127 Groenwold, R.H.H., Hoes, A.W., Nichol, K.L. & Hak, E. (2008). Quantifying the potential role of

unmeasured confounders: the example of influenza vaccination. International journal of

epidemiology, 37(6), 1422-1429.

128 Groot, E. de, Leuven, S.I. van, Duivenvoorden, R., Meuwese, M., Akdim, F., Bots, M.L. & Kastelein, J.J.

(2008). Measurement of carotid intima-media thickness to assess progression and regression of

atherosclerosis. Nature Clinical Practice. Cardiovascular Medicine, 5(5), 280-288.

129 Groot, J.A.H. de, Janssen, K.J.M., Zwinderman, A.H., Moons, K.G.M. & Reitsma, J.B. (2008). Multiple

imputation to correct for partial verification bias revisited. Statistics in Medicine, 27(28), 5880-5889.

130 Hack, K.E.A., Derks, J.B., Elias, S.G., Franx, A., Roos, E.J., Voerman, S.K., Bode, C.L., Esseboom, C. &

Visser, G.H.A. (2008). Increased perinatal mortality and morbidity in monochorionic versus

dichorionic twin pregnancies: clinical implications of a large Dutch cohort study. BJOG - An

International Journal of Obstetrics and Gynaecology, 115(1), 58-67.

131 Hack, K.E.A., Nikkels, P.G.J., Esseboom, C., Derks, J.B., Elias, S.G., Gemert, MJ van & Visser, G.H.A.

(2008). Placental characteristics of monochorionic diamniotic twin pregnancies in relation to

perinatal outcome. Placenta, 29(11), 976-981.

132 Hack, K.E.A., Kaandorp, J.J., Derks, J.B., Elias, S.G., Pistorius, L.R. & Visser, G.H.A. (2008). The value

of umbilical artery Doppler velocimetry in the antenatal surveillance of uncomplicated

monochorionic twin pregnancies. Ultrasound in Obstetrics and Gynecology, 31(6), 662-668.

133 Hak, E. (2008). Collaborative efforts are needed to improve use of influenza immunisation in Europe.

Eurosurveillance Weekly, 13(43), 19011.

134 Hak, E., Sanders, E.A.M., Verheij, Th.J.M., Huijts, S.M., Gruber, W., Tansey, S., McDonough, A.,

Thoma, B., Patterson, S.D., Alphen, A.J.W. van & Bonten, M.J.M. (2008). Rationale and design of

CAPITA: a RCT of 13-valent conjugated pneumococcal vaccine efficacy among older adults.

Netherlands Journal of Medicine, 66(9), 378-383.

135 Halkes, P.H.A., Gray, L.J., Bath, P.M., Diener, H.-C., Guiraud-Chaumeil, B., Yatsu, F. & Algra, A. (2008). Dipyridamole plus aspirin in secondary prevention after transient ischemic attack or stroke of

arterial origin: a meta-analysis by risk based on individual patient data from randomised trials.

Journal of Neurology, Neurosurgery and Psychiatry, 79, 1218-1223.

136 Havenaar, J.M., Geerlings, M.I., Vivian, L., Collinson, M.E. & Robertson, B. (2008). Common mental

health problems in historically disadvantaged urban and rural communities in South Africa:

prevalence and risk factors. Social Psychiatry and Psychiatric Epidemiology, 43(3), 209-215.

137 Hecke, A. van, Grypdonck, M.H.F. & Defloor, T. (2008). Interventions to enhance patient compliance

with leg ulcer treatment: a review of the literature. Journal of Clinical Nursing, 17(1), 29-39.

138 Heikens, E., Schaik, W. van, Laevis, H.L., Bonten, M.J.M. & Willems, R.J.L. (2008). Identification of a

novel genomic island specific to hospital-acquired clonal complex 17 Enterococcus faecium isolates.

Applied and Environmental Microbiology, 74(22), 7094-7097.


139 Helgadottir, A., Thorleifsson, G., Magnusson, K.P., Gretarsdottir, S., Steinthorsdottir, V., Manolescu,

A., Jones, G.T., Rinkel, G.J.E., Blankensteijn, J.D., Ronkainen, A., Jaaskelainen, J.E., Kyo, Y., Lenk, G.M.,

Sakalihasan, N., Kostulas, K., Gottsater, A., Flex, A., Stefansson, H., Hansen, T., Andersen, G.,

Weinsheimer, S., Borch-Johnsen, K., Jorgensen, T., Shah, S.H., Ouyyumi, A.A., Granger, C.B., Reilly,

M.P., Austin, H., Levey, A.I., Vaccarino, V, Palsdottir, E., Walters, G.B., Jonsdottir, T., Snorradottir, S.,

Magnusdottir, D., Gudmundsson, G., Ferrell, R.E., Sveinbjornsdottir, S., Hernesniemi, J., Niemela, M.,

Limet, R.V., Andersen, K., Sigurdsson, G., Benediktsson, R., Verhoeven, E.L., Teijink, J.A., Grobbee, D.E., Rader, D.J., Collier, D.A., Pedersen, O., Pola, R., Hillert, J., Lindblad, B., Valdimarsson, E.M.,

Magnadottir, H.B., Wijmenga, C., Tromp, G., Baas, A.F., Ruigrok, Y.M., Rij, A.M. van, Kuivaniemi, H.,

Powell, J.T., Matthiasson, S.E., Gulcher, J.R., Thorgeirsson, G., Kong, A., Thorsteinsdottir, U. &

Stefansson, K. (2008). The same sequence variant on 9p21 associates with myocardial infarction,

abdominal aortic aneurysm and intracranial aneurysm. Nature Genetics, 40(2), 217-224.

140 Hendrickx, A.P.A., Bonten, M.J.M., Luit-Asbroek, M. van, Schapendonk, C.M., Kragten, A.H. &

Willems, R.J.L. (2008). Expression of two distinct types of pili by a hospital-acquired Enterococcus

faecium isolate. Microbiology, 154(10), 3212-3223.

141 Hertog, H.M. den, Worp, H.B. van der, Gemert, H.M. van, Algra, A., Kappelle, L.J., Gijn, J. van,

Koudstaal, P.J. & Dippel, D.W.J. (2008). Correction: PAIS: paracetamol (acetaminophen) in stroke;

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142 Hertogh, E.M., Monninkhof, E.M., Schouten, E.G., Peeters, P.H.M. & Schuit, A.J. (2008). Validity of

the Modified Baecke Questionnaire: comparison with energy expenditure according to the doubly

labeled water method. The International Journal of Behavioral Nutrition and Physical Activity, 27(5),

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143 Heuven, A.W. van, Dorhout Mees, S.M., Algra, A. & Rinkel, G.J.E. (2008). Validation of a prognostic

subarachnoid hemorrhage grading scale derived directly from the Glasgow Coma Scale. Stroke, 39(4),

1347-1348.

144 Himbergen, T.M. van, Schouw, Y.T. van der, Voorbij, H.A.M., Tits, L.J. van, Stalenhoef, A.F., Peeters, P.H.M. & Roest, M. (2008). Paraoxonase (PON1) and the risk for coronary heart disease and

myocardial infarction in a general population of Dutch women. Atherosclerosis, 199(2), 408-414.

145 Ho, V.K., Heiden-van der Loo, M. van der, Rutgers, E.J., Diest, P.J. van, Hobbelink, M.G.G., Tjan-

Heijnen, V.C., Dirx, M, Reedijk, A.M., Dijck, J. van, Poll-Franse, L.V. van de, Schaapveld, M. & Peeters, P.H.M. (2008). Implementation of sentinel node biopsy in breast cancer patients in the Netherlands.

European Journal of Cancer, 44(5), 683-691.

146 Hoff, R.G., Dijk, G.W. van, Algra, A., Kalkman, C.J. & Rinkel, G.J.E. (2008). Fluid balance and blood

volume measurement after aneurysmal subarachnoid hemorrhage. Neurocritical Care, 8(3), 391-397.

147 Hoff, R.G., Dijk, G.W. van, Mettes, S., Verweij, B.H., Algra, A., Rinkel, G.J.E. & Kalkman, C.J. (2008).

Hypotension in anaesthetized patients during aneurysm clipping: not as bad as expected? Acta

Anaesthesiologica Scandinavica, 52(7), 1006-1011.

148 Hoff, R.G., Rinkel, G.J.E., Verweij, B.H., Algra, A. & Kalkman, C.J. (2008). Nurses prediction of

volume status after aneurysmal subarachnoid. Critical Care [E], 12, R153.

149 Hofhuis, J.G., Spronk, P.E., Stel, H.F. van & Schrijvers, A.J.P. (2008). Experiences of critically ill

patients in the ICU. Intensive and critical care nursing, 24(5), 300-313.

150 Hofhuis, J.G., Spronk, P., Stel, H.F. van, Schrijvers, A.J.P., Rommes, J. & Bakker, P.J. (2008). The

impact of critical illness on perceived health related quality of life during ICU treatment, hospital stay,

and after hospital discharge; a long-term follow up study. Chest, 133(2), 377-385.

151 Hofhuis, J.G., Spronk, P.E., Stel, H.F. van, Schrijvers, A.J.P., Rommes, J.H. & Bakker, J. (2008). The

impact of severe sepsis on health-related quality of life: a long-term follow-up study. Anesthesia and

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152 Hofmeijer, J., Anema, P.C. & Tweel, I. van der (2008). New algorithm for treatment allocation reduced

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153 Hofmeijer, J., Algra, A., Kappelle, L.J. & Worp, H.B. van der (2008). Predictors of life-threatening

brain edema in middle cerebral artery infarction. Cerebrovascular Diseases, 25(1-2), 176-184.

154 Howard, S.C., Algra, A. & Rothwell, P.M. (2008). Effect of age and glycaemic control on the

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155 Huijbregts, H.J.T.A.M., Bots, M.L., Wittens, C.H.A., Schrama, Y.C., Moll, F.L. & Blankestijn, P.J.

(2008). Hemodialysis Arteriovenous Fistula Patency Revisited: Results of a Prospective, Multicenter

Initiative. Clinical Journal of the American Society of Nephrology, 3(3), 714-719.

156 Ista, E., Dijk, M. van, Gamel, C.J., Tibboel, D. & Hoog, M. (2008). Withdrawal symptoms in critically

ill children after long-term administration of sedatives and/or analgesics: a first evaluation. Critical

Care Medicine, 36(8), 2437-2432.

157 Jaarsma, T., Wal, M.H. van der, Lesman-Leegte, I, Luttik, M.L., Hogenhuis, J., Veeger, N.J., Sanderman,

R., Hoes, A.W., Gilst, W.H. Van, Lok, DJ, Dunselman, P.H., Tijssen, J.G., Hillege, H.L. & Veldhuisen,

D.J. van (2008). Effect of moderate or intensive disease management program on outcome in patients

with heart failure: Coordinating Study Evaluating Outcomes of Advising and Counseling in Heart

Failure (COACH). Archives of Internal Medicine, 168(3), 316-324.

158 Jabaaij, L., Fassaert, Th., Dulmen, S van, Timmermans, A., Essen, G.A. van & Schellevis, F. (2008).

Familiarity between patient and general practitioner does not influence the content of the

consultation. BMC Family Practice [E], 9, 51.

159 Jacobs, P.C.A., Mali, W.P.T.M., Grobbee, D.E. & Graaf, Y. van der (2008). Prevalence of incidental

findings in computed tomographic screening of the chest: a systematic review. Journal of Computer

Assisted Tomography, 32(2), 214-221.

160 Jacobsen, D.E., Samson, M.M., Schouw, Y.T. van der, Grobbee, D.E. & Verhaar, H.J.J. (2008). Efficacy

of tibolone and raloxifene for the maintenance of skeletal muscle strength, bone mineral density,

balance, body composition, cognitive function, mood/depression, anxiety and quality of life/well-

being in late postmenopausal women >/= 70 years: Study design of randomized, double-blind,

double-dummy, placebo-controlled, single-center trial. Trials [E], 9(1), 32-32.

161 Jaddoe, V.W., Ridder, M.A. de, Elzen, A.P. van den, Hofman, A., Uiterwaal, C.S.P.M. & Witteman, J.C.

(2008). Maternal smoking in pregnancy is associated with cholesterol development in the offspring.

Atherosclerosis, 196(1), 42-48.

162 Janse, A.J., Sinnema, G., Uiterwaal, C.S.P.M., Kimpen, J.L.L. & Gemke, R.J.B.J. (2008). Quality of life

in chronic illness: children, parents and paediatricians have different, but stable perceptions. Acta

Paediatrica, 97(8), 1118-1124.

163 Jansen, A.G.S.C., Sanders, E.A.M., Smulders, S., Hoes, A.W. & Hak, E. (2008). Adverse reactions to

simultaneous influenza and pneumococcal conjugate vaccinations in children: randomized double-

blind controlled trial. Pediatric Allergy and Immunology, 19(6), 552-558.

164 Jansen, A.G.S.C., Sanders, E.A.M., Nichol, K.L., Loon, A.M. van, Hoes, A.W. & Hak, E. (2008).

Decline in influenza-associated mortality among Dutch elderly following the introduction of a

nationwide vaccination program. Vaccine, 26(44), 5567-5574.

165 Jansen, A.G.S.C., Sanders, E.A.M., Hoes, A.W., Loon, A.M. van & Hak, E. (2008). Effects of influenza

plus pneumococcal conjugate vaccination versus influenza vaccination alone in preventing

respiratory tract infections in children: a randomized, double-blind, placebo-controlled trial. The

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166 Jansen, A.G.S.C., Sanders, E.A.M., Hoes, A.W., Loon, A.M. van & Hak, E. (2008). Erratum: Influenza-

and respiratory syncytial virus-associated mortality and hospitalisations. European Respiratory

Journal, 31(3), 691.

167 Jansen, A.G.S.C., Sanders, E.A.M., Ende, A. van der, Loon, A.M. van, Hoes, A.W. & Hak, E. (2008).

Invasive pneumococcal and meningococcal disease: association with influenza virus and respiratory

syncytical virus activity? Epidemiology and Infection, 136(11), 1448-1454.


168 Jansen, A.G.S.C., Sanders, E.A.M., Wallinga, J., Groen, E.J., Loon, A.M. van, Hoes, A.W. & Hak, E. (2008). Rate-difference method proved satisfactory in estimating the influenza burden in primary

care visits. Journal of Clinical Epidemiology, 61(8), 803-812.

169 Jansen, F.E., Vincken, K.L., Algra, A., Anbeek, P., Braams, O.B., Nellist, M, Zonnenberg, B.A.,

Jennekens-Schinkel, A., Ouweland, A.M.W. van den, Halley, D.J.J., Huffelen, A.C. van &

Nieuwenhuizen, O. van (2008). Cognitive impairment in tuberous sclerosis complex is a

multifactorial condition. Neurology, 70(12), 916-923.

170 Jansen, F.E., Braams, O.B., Vincken, K.L., Algra, A., Anbeek, P., Jennekens-Schinkel, A., Halley, D.,

Zonnenberg, B.A., Ouweland, A.M.W. van den, Huffelen, A.C. van, Nieuwenhuizen, O. van & Nellist,

M (2008). Overlapping neurological and cognitive phenotypes in patients with TSC1 or TSC2

mutations. Neurology, 70, 908-915.

171 Janssen, K.J.M., Kalkman, C.J., Grobbee, D.E., Bonsel, G.J., Moons, K.G.M. & Vergouwe, Y. (2008).

The risk of severe postoperative pain: modification and validation of a clinical prediction rule.

Anesthesia and Analgesia, 107(4), 1330-1339.

172 Janssen, K.J.M., Moons, K.G.M., Kalkman, C.J., Grobbee, D.E. & Vergouwe, Y. (2008). Updating

methods improved the performance of a clinical prediction model in new patients. Journal of Clinical


173 Janssen, M.P., Over, J., Poel, C.L. van der, Cuijpers, H.T.M. & Hout, B.A. van (2008). A probabilistic

model for analyzing viral risks of plasma-derived medicinal products. Transfusion, 48(1), 153-62.

174 Janssen, M.P., Borst, G.J. de, Mali, W.P.T.M., Kappelle, L.J., Moll, F.L., Ackerstaff, R.G., Rothwell, P.M.,

Brown, M.M., Sambeek, M.R. & Buskens, E. (2008). Carotid stenting versus carotid endarterectomy:

evidence basis and cost implications. European Journal of Vascular and Endovascular Surgery, 36(3),

258-264.

175 Janssen, N.A.H., Meliefste, K., Fuchs, O., Weiland, S.K., Cassee, F.R., Brunekreef, B. & Sandstrom, T.

(2008). High and low volume sampling of particulate matter at sites with different traffic profiles in

the Netherlands and Germany: Results from the HEPMEAP study. Atmospheric Environment, 42(6),

1110-1120.

176 Janssen, P.G.H., Gorter, K.J., Stolk, R.P. & Rutten, G.E.H.M. (2008). Do characteristics of practices

and general practitioners influence the yield of diabetes screening in primary care? The ADDITION

Netherlands study. Scandinavian journal of primary health care, 26(3), 160-165.

177 Janssen, P.G.H., Gorter, K.J., Stolk, R.P., Akarsubasi, M. & Rutten, G.E.H.M. (2008). Three years

follow-up of screen-detected diabetic and non-diabetic subjects: who is better off? The ADDITION

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178 Jenab, M., McKay, J.D., Ferrari, P., Biessy, C., Laing, S., Munar, G.M., Sala, N., Pena, S., Crusius, J.B.A.,

Overvad, K., Jensen, M.K., Olsen, A., Tjonneland, A., Clavel-Chapelon, F., Boutron-Ruault, M.C.,

Kaaks, R., Linseisen, J., Boeing, H., Bergmann, M.M., Trichopoulou, A., Georgila, C., Psaltopoulou, T.,

Mattiello, A., Vineis, P., Pala, V., Palli, D., Tumino, R., Numans, M.E., Peeters, P.H.M., Bueno-de-

Mesquita, H.B., Lund, E., Ardanaz, E., Sanchez, M.J., Dorronsoro, M., Sanchez, C.N., Quiros, J.R.,

Hallmans, G., Stenling, R., Manjer, J., Regner, S., Key, T.J., Bingham, S, Khaw, K.T., Slimani, N.,

Rinaldi, S., Boffetta, P., Carneiro, F., Riboli, E. & Gonzalez, C. (2008). CDH1 gene polymorphisms,

smoking, Helicobacter pylori infection and the risk of gastric cancer in the European Prospective

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179 Jonge, E de, Peelen, L.M., Keijzers, P.J., Joore, H., Lange, D. de, Voort, P.H., Bosman, R.J., Waal, R.A.,

Wesselink, R. & Keijzer, N.F. de (2008). Association between administered oxygen, arterial partial

oxygen pressure and mortality in mechanically ventilated intensive care unit patients. Critical Care

[E], 12(6), R156.

180 Jongh, M.A.C. de, Meeuwis, J.D., Baar, M.E. van, Stel, H.F. van, Schrijvers. A.J.P. (2008). Evaluation

of trauma care by comparing mortality risks and admission policy in a Dutch trauma region. Injury,

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181 Joosten, E.A.G., Weert, G.H. de, Sensky, T., Staak, C.P.F. van der & Jong, C.A.J. de (2008). Effect of

shared decision-making on therapeutic alliance in addiction health care. Patient Preference and

Adherence, 2, 277-285.

182 Joosten, E.A.G., DeFuentes-Merillas, L., Weert, G.H. de, Sensky, T., Staak, C.P.F. van der & Jong, C.A.J.

de (2008). Systematic Review of the Effects of shared Decision-Making on Patient Satisfaction,

Treatment Adherence and Health Status. Psychotherapy and Psychosomatics, 77(4), 219-226.

183 Kahn, R.S., Fleischhacker, WW, Boter, H., Davidson, M., Vergouwe, Y., Keet, I.P.M., Gheorghe, M.D.,

Rybakowski, J.K., Galderisi, S., Libiger, J., Hummer, M., Dollfus, S., Lopez-Ibor, J.J., Hranov, L.G.,

Gaebel, W., Peuskens, J., Lindefors, N., Riecher-Rossler, A. & Grobbee, D.E. (2008). Effectiveness of

antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: an open

randomised clinical trial. Lancet, 29(371), 1085-1097.

184 Kamphuis, M.H., Geerlings, M.I., Grobbee, D.E. & Kromhout, D. (2008). Dietary intake of B(6-9-12)

vitamins, serum homocysteine levels and their association with depressive symptoms: the Zutphen

Elderly Study. European Journal of Clinical Nutrition, 62(8), 939-945.

185 Kars, M.C., Duijnstee, M.S.H., Pool, A., Delden, J.J.M. van & Grypdonck, M.H.F. (2008). Being there:

parenting the child with acute lymphoblastic leukaemia. Journal of Clinical Nursing, 17(12), 1553-

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186 Kastelein, J.J., Akdim, F., Stroes, E.S.G., Zwinderman, A.H., Bots, M.L., Stalenhoef, A.F., Visseren,

F.L.J., Sijbrands, E.J., Trip, M.D., Stein, E.A., Gaudet, D., Duivenvoorden, R., Veltri, E.P., Marais, A.D.,

Groot, E. de & ENHANCE, Investigators (2008). Simvastatin with or without ezetimibe in familial

hypercholesterolemia. New England Journal of Medicine, 358(14), 1431-1443.

187 Khan, A.E., Gallo, V., Linseisen, J., Kaaks, R., Rohrmann, S., Raaschou-Nielsen, O., Tjonneland, A.,

Johnsen, H.E., Overvad, K., Bergmann, M.M., Boeing, H., Benetou, V., Psaltopoulou, T.,

Trichopoulou, A., Masala, G., Mattiello, A., Grioni, S., Tumino, R., Vermeulen, R.C.H., Peeters, P.H.M., Bueno-de-Mesquita, H.B., Ros, M.M., Lund, E., Ardanaz, E., Chirlaque, M.D., Jakszyn, P., Larranaga,

N., Losada, A., Becker, N., Nieters, A., Martinez-Garcia, C., Agren, A., Hallmans, G., Berglund, G.,

Manjer, J., Allen, N.E., Key, T.J., Bingham, S, Khaw, K.T., Slimani, N., Ferrari, P., Boffetta, P., Norat, T.,

Vineis, P., Riboli, E. & EPIC, Group (2008). Diabetes and the risk of non-Hodgkin’s lymphoma and

multiple myeloma in the European Prospective Investigation into Cancer and Nutrition.

Haematologica, 93(6), 842-850.

188 King, M., Walker, C., Levy, G., Bottomley, C., Royston, P., Weich, S., Bellon-Saameno, J.A., Moreno, B.,

Svab, I., Rotar, D., Rifel, J., Maaroos, H., Aluoja, A., Kalda, R., Neeleman, J., Geerlings, M.I., Xavier,

M., Carraca, I., Goncalves-Pereira, M., Vicente, B., Saldivia, S., Melipillan, R., Torres-Gonzalez, F. &

Nazareth, I. (2008). Development and Validation of an International Risk Prediction Algorithm for

Episodes of Major Depression in General Practice Attendees: The PredictD Study. Archives of General

Psychiatry, 65(12), 1368-1376.

189 King, M., Nazareth, I., Levy, G., Walker, C., Morris, R., Weich, S., Bello-Saameno, J.A., Moreno, B.,

Svab, I., Rotar, D., Rifel, J., Maaroos, H., Aluoja, A., Kalda, R., Neeleman, J., Geerlings, M.I., Xavier,

M., Almeida, M.C. de, Correa, B. & Torres-Gonzalez, F. (2008). Prevalence of common mental

disorders in general practice attendees across Europe. British Journal of Psychiatry, 192(5), 362-367.

190 Klungel, O.H., Storimans, M.J., Floor-Schreudering, A., Talsma, H., Rutten, G.E.H.M. & Blaey, C.J. de

(2008). Perceived diabetes status is independently associated with glucose monitoring behaviour

among type 2 diabetes mellitus patients. Primary Care Diabetes, 2, 25-30.

191 Knauff, A.H., Westerveld, H.E., Goverde, A.J., Eijkemans, M.J., Valkenburg, O., Santbrink, E.J. van,

Fauser, B.C.J.M. & Schouw, Y.T. van der (2008). Lipid profile of women with premature ovarian

failure. Menopause, 15(5), 919-923.

192 Kneyber, M.C.J., Woensel, J.B.M. van, Uijtendaal, E.V., Uiterwaal, C.S.P.M. & Kimpen, J.L.L. (2008).

Azithromycin does not improve disease course in hospitalized infants with respiratory syncytial virus

(RSV) lower respiratory tract disease: A randomized equivalence trial. Pediatric pulmonology,

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193 Knol, M.J., Derijks, H.J., Geerlings, M.I., Heerdink, E.R., Souverein, P.C., Gorter, K.J., Grobbee, D.E. & Egberts, A.C.G. (2008). Influence of antidepressants on glycaemic control in patients with diabetes

mellitus. Pharmacoepidemiology and Drug Safety, 17(6), 577-586.

194 Knol, M.J., VandenBroucke, J.P., Scott, P. & Egger, M. (2008). What Do Case-Control Studies

Estimate? Survey of Methods and Assumptions in Published Case-Control Research. American

Journal of Epidemiology, 168(9), 1073-1081.

195 Koekkoek, B., Meijel, B.K.G. van, Schene, A. & Hutschemaekers, G. (2008). Clinical problems in the

long-term care of patients with chronic depression. Journal of Advanced Nursing, 62(6), 89-97.

196 Koffijberg, H., Buskens, E., Algra, A., Wermer, M.J.H. & Rinkel, G.J.E. (2008). Growth rates of

intracranial aneurysms: exploring constancy. Journal of Neurosurgery, 109(2), 176-185.

197 Koffijberg, H., Buskens, E., Granath, F., Adami, J., Ekbom, A., Rinkel, G.J.E. & Blomqvist, P. (2008).

Subarachnoid haemorrhage in Sweden 1987-2002: regional incidence and case fatality rates. Journal

of Neurology, Neurosurgery and Psychiatry, 79(3), 294-299.

198 Kooij, B.J.M. van, Handel, M. van, Uiterwaal, C.S.P.M., Groenendaal, F., Nievelstein, R.A.J.,

Rademaker, K.J., Jongmans, M.J. & Vries, L.S. de (2008). Corpus Callosum Size in Relation to Motor

Performance in 9- to 10-Year-Old Children with Neonatal Encephalopathy. Pediatric Research, 63(1),

103-108.

199 Koopman, L., Heijden, G.J.M.G. van der, Glasziou, P.P., Grobbee, D.E. & Rovers, M.M. (2008). A

systematic review of analytical methods used to study subgroups in (individual patient data) meta

analyses. Journal of Clinical Epidemiology, 60(10), 1002-1009.

200 Koopman, L., Hoes, A.W., Glasziou, P.P., Appelman, C.L.M., Burke, P., McCormick, D.P.,

Damoiseaux, R.A.M.J., Saux, N. Le & Rovers, M.M. (2008). Antibiotic therapy to prevent the

development of asymptomatic middle ear effusion in children with acute otitis media: a meta-analysis

of individual patient data. Archives of Otolaryngology - Head & Neck Surgery, 134(2), 128-132.

201 Koopman, L., Heijden, G.J.M.G. van der, Grobbee, D.E. & Rovers, M.M. (2008). Comparison of

methods of handling missing data in individual patient data meta-analyses: an empirical example on

antibiotics in children with acute otitis media. American Journal of Epidemiology, 167(5), 540-545.

202 Koopman, L., Heijden, G.J.M.G. van der, Hoes, A.W., Grobbee, D.E. & Rovers, M.M. (2008).

Empirical comparison of subgroup effects in conventional and individual patient data meta-analyses.

International Journal of Technology Assessment in Health Care, 24(3), 358-361.

203 Korstjens, I., May-de Groot, A.M., Weert, E. van, Mesters, I., Tan, F., Ros, W.J.G., Hoekstra-Weebers,

J.E., Schans, C.P. van der & Borne, B. van den (2008). Quality of life after self-management cancer

rehabilitation: a randomized controlled trial comparing physical and cognitive-behavioral training

versus physical training. Psychosomatic Medicine, 70(4), 422-429.

204 Kretzschmar, M.E.E. & Mikolajczyk, R (2008). Collecting social contact data in the context of

diasease transmission: prospective study designs. Social Networks, 30, 127-135.

205 Kretzschmar, M.E.E. & Wiessing, L.G. (2008). New challenges for mathematical and statistical

modeling of HIV and hepatitis C virus in injecting drug users. AIDS, 22(13), 1527-1537.

206 Kretzschmar, M.E.E., Zhang, W., Mikolajczyk, R.T., Wang, L., Sun, X., Kramer, A. & Lv, F (2008).

Regional differences in HIV prevalence among drug users in China: potential for future spread of

HIV? BMC Infectious Diseases, 4(8), 108.

207 Kretzschmar, M.E.E. & Wit, G.A. de (2008). Universal hepatitis B vaccination. The Lancet Infectious

Diseases, 8(2), 85-87.

208 Kretzschmar, M.E.E. (2008). Infectious Disease Modeling. In International Encyclopedia of Public

Health, Kris Heggenhougen and Stella Quah. San Diego: Academic Press.

209 Kretzschmar, M.E.E. (2008). Infectious Disease Modeling. In Kris Heggenhougen and Quah, editors

International Encyclopedia of Public Health. San Diego: Academic Press.

Publications 199

210 Kruyt, N.D., Roos, Y.W., Dorhout Mees, S.M., Berg, W.M. van den, Algra, A., Rinkel, G.J.E. & Biessels,

G.J. (2008). High mean fasting glucose levels independently predict poor outcome and delayed

cerebral ischemia after aneurysmal subarachnoid haemorrhage. Journal of Neurology, Neurosurgery

and Psychiatry, 79, 1382-1385.

211 Laar, P.J. van, Graaf, Y. van der, Mali, W.P.T.M., Grond, J. van der, Hendrikse, J. & SMART, Study

(2008). Effect of cerebrovascular risk factors on regional cerebral blood flow. Radiology, 246(1), 198-

204.

212 Laar, P.J. van, Raamt, A.F. van, Grond, J. van der, Mali, W.P.T.M., Graaf, Y. van der, Hendrikse, J. &

SMART, Study (2008). Increasing levels of TNFalpha are associated with increased brain perfusion.

Atherosclerosis, 196(1), 449-454.

213 Lambers Heerspink, H.J., Dobre, D., Hillege, H.L., Grobbee, D.E. & Zeeuw, D. de (2008). Does the

European clinical trials directive really improve clinical trial approval time? British Journal of Clinical

Pharmacology, 66(4), 546-550.

214 Lambers Heerspink, H.J., Knol, M.J., Tijssen, R.J., van Leeuwen, T.N., Grobbee, D.E. & Zeeuw, D. de

(2008). Is the randomized controlled drug trial in Europe lagging behind the USA? British Journal of

Clinical Pharmacology, 66(6), 774-780.

215 Leeflang, M.M., Moons, K.G.M., Reitsma, J.B. & Zwinderman, A.H. (2008). Bias in sensitivity and

specificity caused by data-driven selection of optimal cutoff values: mechanisms, magnitude, and

solutions. Clinical chemistry, 54((4)), 729-737.

216 Leendertse, M., Willems, R.J.L., Giebelen, A.J., Pangaart, P.S. van den, Wiersinga, W.J., Vos, A.F. de,

Florquin, S., Bonten, M.J.M. & Poll, T. van der (2008). TLR2-dependent MyD88 signaling contributes

to early host defense in murine Enterococcus faecium peritonitis. Journal of Immunology, 180(7),

4865-4874.

217 Leeuw, J.R.J. de, Vliet, M.J. van & Ausems, M.G.E.M. (2008). Predictors of choosing life-long

screening or prophylactic surgery in women at high and moderate risk for breast and ovarian cancer.

Familial Cancer, 7(4), 347-359.

218 Lemmens, L.C., Kerkkamp, H.E.M., Klei, W.A. van, Klazinga, N.S., Rutten, C.L.G., Linge, R.H. van &

Moons, K.G.M. (2008). Facilitating and limiting factors for implmentation of outpatient preoperative

evaluation clinics. British Journal of Anaesthesia, 100, 645-651.

219 Lemmens, L.C., Kerkkamp, H.E.M., Klei, W.A. van, Klazinga, N.S., Rutten, C.L., Linge, R.H. van &

Moons, K.G.M. (2008). Implementation of outpatient preoperative evaluation clinics: facilitating and

limiting factors. British Journal of Anaesthesia, 100(5), 645-651.

220 Lips, I.M., Dehnad, H., Gils, C.H. van, Boeken Kruger, A.E., Heide, U.A. van der & Vulpen, M. van

(2008). High-dose intensity-modulated radiotherapy for prostate cancer using daily fiducial marker-

based position verification: acute and late toxicity in 331 patients. Radiation Oncology [E], 21(3), 15.

221 Lübbeke, A., Moons, K.G.M., Garavaglia, G. & Hoffmeyer, P. (2008). Outcomes of obese and

nonobese patients undergoing revision total hip arthroplasty. Arthritis and Rheumatism, 59(5), 738-

745.

222 Lumbreras, B., Garte, S., Overvad, K., Tjonneland, A., Clavel-Chapelon, F., Linseisen, J., Boeing, H.,

Trichopoulou, A., Palli, D., Peluso, M., Krogh, V., Tumino, R., Panico, S., Bueno-de-Mesquita, H.B.,

Peeters, P.H.M., Lund, E., Martinez, C., Dorronsoro, M., Barricarte, A., Chirlaque, M.D., Quiros, J.R.,

Berglund, G., Hallmans, G., Day, N.E., Key, T.J., Saracci, R., Kaaks, R., Malaveille, C., Ferrari, P.,

Boffetta, P., Norat, T., Riboli, E., Gonzalez, C.A. & Vineis, P. (2008). Meat intake and bladder cancer in

a prospective study: a role for heterocyclic aromatic amines? Cancer Causes & Control, 19(6), 649-

656.

223 Lutgens, M.W.M.D., Meijer, M, Peeters, B.P., Poulsen, M.L., Rutten, M.J., Bots, M.L., Heijden, G.J.M.G. van der & Soedamah-Muthu, S.S (2008). Easily obtainable clinical features increase the

diagnostic accuracy for latent autoimmune diabetes in adults: an evidence-based report. Primary Care

Diabetes, 2(4), 207-211.


224 Manschot, S.M., Biessels, G.J., Rutten, G.E.H.M., Kessels, R.C., Gispen, W.H. & Kappelle, L.J. (2008).

Peripheral and central neurologic complications in type 2 diabetes mellitus: No association in

individual patients. Journal of the Neurological Sciences, 264(1-2), 157-162.

225 Marschall, T, Kretzschmar, M.E.E., Mangen, M.J.J. & Schalm, S. (2008). High impact of migration on

the prevalence of chronic hepatitis B in the Netherlands. European Journal of Gastroenterology and

Hepatology, 20(12), 1214-1225.

226 Martens, F.M.A.C., Graaf, Y. van der, Dijk, J.M., Olijhoek, J.K. & Visseren, F.L.J. (2008). Carotid

arterial stiffness is marginally higher in the metabolic syndrome and markedly higher in type 2

diabetes mellitus in patients with manifestations of arterial disease. Atherosclerosis, 197(2), 646-653.

227 May, A.M., Weert, E. van, Korstjens, I., Hoekstra-Weebers, J.E., Schans, C.P. van der, Zonderland, M.L.,

Mesters, I., Borne, B.V. & Ros, W.J.G. (2008). Improved physical fitness of cancer survivors: a

randomised controlled trial comparing physical training with physical and cognitive-behavioural

training. Acta Oncologica, 47(5), 1825-1834.

228 May-de Groot, A.M., Duivenvoorden, H.J., Korstjens, I., Weert, E. van, Hoekstra-Weebers, J.E., Borne,

B. van den, Mesters, I., Schans, C.P. van der & Ros, W.J.G. (2008). The effect of group cohesion on

rehabilitation outcome in cancer survivors. Psycho-oncology, 17(9), 917-925.

229 McKay, J.D., Hung, R.J., Gaborieau, V., Boffetta, P., Chabrier, A., Byrnes, G.B., Zaridze, D., Mukeria, A.,

Szeszenia-Dabrowska, N., Lissowska, J, Rudnai, P., Fabianova, E., Mates, D., Bencko, V., Foretova, L.,

Janout, V., McLaughlin, J., Shepherd, F., Montpetit, A., Narod, S., Krokan, H.E., Skorpen, F., Elvestadt,

M.B., Vatten, L., Njolstad, I., Axelsson, T., Chen, C., Goodman, G., Barnett, M., Loomis, M.M.,

Lubinski, J., Matyjasik, J., Lener, M., Oszutowska, D., Field, J., Liloglou, T., Xinarianos, G., Cassidy, A.,

Vineis, P., Clavel-Chapelon, F., Palli, D., Tumino, R., Krogh, V., Panico, S., Gonzalez, C.A., Ramon

Quiros, J., Martinez, C., Navarro, C., Ardanaz, E., Larranaga, N., Kham, K.T., Key, T.J., Bueno-de-

Mesquita, H.B., Peeters, P.H.M., Trichopoulou, A., Linseisen, J., Boeing, H., Hallmans, G., Overvad,

K., Tjonneland, A., Kumle, M., Riboli, E., Zelenika, D., Boland, A., Delepine, M., Foglio, M., Lechner,

D., Matsuda, F., Blanche, H., Gut, I., Health, S., Lathrop, M. & Brennan, P. (2008). Lung cancer

susceptibility locus at 5p15.33. Nature Genetics, 40(12), 1404-1406.

230 Meijer-Hoogeveen, M., Holsbeke, C. van, Tweel, I. van der, Stoutenbeek, Ph. & Visser, G.H.A. (2008).

Sonographic longitudinal cervical length measurements in nulliparous women at term: prediction of

spontaneous onset of labor. Ultrasound in Obstetrics and Gynecology, 32(5), 652-656.

231 Metz, R., Verleisdonk, E.J.M.M., Heijden, G.J.M.G. van der, Clevers, G.J., Hammacher, E.R.,

Verhofstad, M.H.J. & Werken, Chr. van der (2008). Acute Achilles Tendon Rupture: Minimally

Invasive Surgery Versus Nonoperative Treatment With Immediate Full Weightbearing--A

Randomized Controlled Trial. American Journal of Sports Medicine, 36(9), 1688-1694.

232 Mikolajczyk, R, Akmatov, M, Rastin, S & Kretzschmar, M.E.E. (2008). Social contacts of school

children and the transmission of respiratory-spread pathogens. Epidemiology and Infection, 136(6),

813-822.

233 Mikolajczyk, R.T., Akmatov, M.K., Stich, H., Kramer, A. & Kretzschmar, M.E.E. (2008). Association

between acculturation and childhood vaccination coverage in migrant populations: a population

based study from a rural region in Bavaria, Germany. International Journal of Public Health, 53(4),

180-187.

234 Molenaar, E.A., Hwang, S.J., Vasan, R.S., Grobbee, D.E., Meigs, J.B., D’Agostino, R.B. Sr, Levy, D. &

Fox, C.S. (2008). Burden and rates of treatment and control of cardiovascular disease risk factors in

obesity: the Framingham Heart Study. Diabetes Care, 31(7), 1367-1372.

235 Monforte, A., Abrams, D., Schneider, M.M.E., Bonten, M.J.M., Borleffs, J.C.C., Ellerbroek, P.M.,

Jaspers, C.A.J.J., Schurink, C.A.M., Hoepelman, I.M. & D.A.D., Study Group (2008). HIV-induced

immunodeficiency and mortality from AIDS-defining and non-AIDS-defining malignancies. AIDS,

22(16), 2143-2153.

Publications 201

236 Mugavero, M.J., May, M., Harris, R., Saag, M.S., Costaliola, D., Egger, M., Phillips, A., Gunthard, H.F.,

Dabis, F., Hogg, R., Wolf, F. de, Fatkenheuer, G., Gill, M.J., Justice, A., D’Armino Montforte, A., Lampe,

F., Miro, J.M., Staszewski, S., Sterne, J.A., Boucher, C.A.B., Bonten, M.J.M., Hoepelman, I.M.,

Schneider, M.M.E., Borleffs, J.C.C., Ellerbroek, P.M., Jaspers, C.A.J.J., Mudrikova, T., Schurink, C.A.M.,

Gisolf, E.H., Geelen, S.P.M., Wolfs, T.F.W., Faber, T.E. & Antiretroviral Therapy Cohort Collaboration,

ART-CC (2008). Does short-term virologic failure translate to clinical events in antiretroviral-naïve

patients initiating antiretroviral therapy in clinical practice? AIDS, 22(18), 2481-2492.

237 Muller, L.M.A.J., Gorter, K.J., Rutten, G.E.H.M., Hoepelman, I.M. & Hak, E. (2008). A clinical

prediction rule for urinary tract infections in patients with type 2 diabetes mellitus in primary care.

Epidemiology and Infection, 137(2), 166-172.

238 Muller, L.M.A.J., Gorter, K.J., Hak, E. & Rutten, G.E.H.M. (2008). Short-term effects of an

educational program on health-seeking behavior for infections in patients with type 2 diabetes: a

randomized controlled intervention trial in primary care. Diabetes Care, 31(3), 402-407.

239 Mylius, S.D., Hagenaars, T.J., Lugner, A.K. & Wallinga, J. (2008). Optimal allocation of pandemic

influenza vaccine depends on age, risk and timing. Vaccine, 26, 3742-3749.

240 Nicholson, A, Berger, K., Bohn, R., Carcao, M., Fischer, K., Gringeri, A., Hoots, K., Mantovani, L.,

Schramm, W., Hout, B.A. van, Willan, A.R. & Feldman, B.M. (2008). Recommendations for reporting

economic evaluations of haemophilia prophylaxis: a nominal groups consensus statement on behalf

of the Economics Expert Working Group of The International Prophylaxis Study Group.

Haemophilia, 14(1), 127-132.

241 Nieboer, P., Vries, E.G.E. de, Mulder, N.H., Rodenhuis, S., Bontenbal, M., Wall, E. van der, Hoesel,

Q.G.C.M. Van, Smit, W.M., Hupperets, P., Voest, E.E., Nooij, M.A., Boezen, H.M. & Graaf, W.T.A. van

der (2008). Factors influencing catheter-related infections in the Dutch multicenter study on highdose

chemotherapy followed by peripheral SCT in high-risk breast cancer patients. Bone Marrow

Transplantation, 42, 475-481.

242 Nierich, A.P., Zaane, B. van, Buhre, W.F., Coddens, J., Spanjersberg, A.J. & Moons, K.G.M. (2008).

Visualization of the distal ascending aorta with A-Mode transesophageal echocardiography. Journal

of Cardiothoracic Vascular Anesthesia, 22(5), 766-773.

243 Nieters, A., Rohrmann, S., Becker, N., Linseisen, J., Ruediger, T., Overvad, K., Tjonneland, A., Olsen,

A., Allen, N.E., Travis, R.C., Bingham, S, Khaw, K.T., Ardanaz, E., Redondo, M.L., Basterrechea, M,

Martinez, C., Tormo, M.J., Rosso, S., Tagliabue, G., Masala, G., Mattiello, A., Tumino, R., Boeing, H.,

Bergmann, M., Kaaks, R., Trichopoulou, A., Trichopoulos, D., Peeters, P.H.M., Bueno-de-Mesquita,

B., Boffetta, P., Brennan, P., Ferrari, P., Neasham, D., Lund, E., Berglund, G., Manjer, J., Hallmans, G.,

Johansson, I., Vineis, P. & Riboli, E. (2008). Smoking and lymphoma risk in the European prospective

investigation into cancer and nutrition. American Journal of Epidemiology, 167(9), 1081-1089.

244 Nijdam, M.E., Plantinga, Y., Hulsen, H.T., Bos, W.J., Grobbee, D.E., Schouw, Y.T. van der & Bots, M.L. (2008). Pulse pressure amplification and risk of cardiovascular disease. American Journal of

Hypertension, 21(4), 388-392.

245 Noss, I., Wouters, I.M., Visser, M., Heederik, D.J.J., Thorne, P.S., Brunekreef, B. & Doekes, G. (2008).

Evaluation of a low-cost electrostatic dust fall collector for indoor air endotoxin exposure assessment.

Applied and Environmental Microbiology, 74(18), 5621-5627.

246 Nothlings, U., Schulze, M.B., Weikert, C., Boeing, H., Schouw, Y.T. van der, Bamia, C., Benetou, V.,

Lagiou, P., Krogh, V., Beulens, J.W.J., Peeters, P.H.M., Halkjaer, J., Tjonneland, A., Tumino, R., Panico,

S., Masala, G., Clavel-Chapelon, F., Lauzon, B. de, Boutron-Ruault, M.C., Vercambre, M.N., Kaaks, R.,

Linseisen, J., Overvad, K., Arriola, L., Ardanaz, E., Gonzalez, C.A., Tormo, M.J., Bingham, S, Khaw,

K.T., Key, T.J., Vineis, P., Riboli, E., Ferrari, P., Boffetta, P., Bueno-de-Mesquita, H.B., A, D.L. van der,

Berglund, G., Wirfalt, E., Hallmans, G., Johansson, I., Lund, E. & Trichopoulo, A. (2008). Intake of

vegetables, legumes, and fruit, and risk for all-cause, cardiovascular, and cancer mortality in a

European diabetic population. Journal of Nutrition, 138(4), 775-781.


247 Oftedal, B., Brunekreef, B., Nystad, W., Madsen, C., Walker, S.E. & Nafstad, P. (2008). Residential

outdoor air pollution and lung function in schoolchildren. Epidemiology, 19(1), 129-137.

248 Olijhoek, J.K., Hajer, G.R., Graaf, Y. van der, Dallinga-Thie, G.M. & Visseren, F.L.J. (2008). The effects

of low-dose simvastatin and ezetimibe compared to high-dose simvastatin alone on post-fat load

endothelial function in patients with metabolic syndrome: a randomized double-blind crossover trial.

Journal of Cardiovascular Pharmacology, 52(2), 145-150.

249 Ong, D.S., Kuyvenhoven, M.M., Dijk, L. van & Verheij, Th.J.M. (2008). Antibiotics for respiratory, ear

and urinary tract disorders and consistency among GPs. Journal of Antimicrobial Chemotherapy,

62(3), 587-592.

250 Opstelten, W., Essen, G.A. van & Hak, E. (2008). Determinants of non-compliance with herpes zoster

vaccination in the community-dwelling elderly. Vaccine, 27(2), 192-196.

251 Opstelten, W. & Zaal, M.J.W. (2008). Diagnostic tips for ophthalmic zoster. The Journal of Family

Practice, 57(2), 81.

252 Opstelten, W., Essen, G.A. van, Ballieux, M.J. & Goudswaard, A.N. (2008). Influenza immunization

of Dutch general practitioners: Vaccination rate and attitudes towards vaccination. Vaccine, 26(47),

5918-5921.

253 Opstelten, W., Eekhof, J.A.H., Neven, A.K. & Verheij, Th.J.M. (2008). Treatment of herpes zoster.

Canadian family physician, 54(3), 373-377.

254 Os-Medendorp, H. van, Guikers, C.L.H., Eland-de Kok, P.C.M., Ros, W.J.G., Bruijnzeel-Koomen,

C.A.F.M. & Buskens, E. (2008). Costs and cost-effectiveness of the nursing programme “Coping with

itch” for patients with chronic pruritic skin disease. British Journal of Dermatology, 158, 1013-1021.

255 Os-Medendorp, H. van, Eland-de Kok, P.C.M., Linge, R.H. van, Bruijnzeel-Koomen, C.A.F.M.,

Grypdonck, M.H.F. & Ros, W. (2008). The tailored implementation of the nursing programme

“coping with itch”. Journal of Clinical Nursing, 17(11), 1460-1470.

256 Otten, C.M, Kok, L., Witteman, B.J., Baumgarten, R., Kampman, E., Moons, K.G.M. & Wit, N.J. de

(2008). Diagnostic performance of rapid tests for detection of fecal calprotectin and lactoferrin and

their ability to discriminate inflammatory from irritable bowelsyndrome. Clinical Chemistry and

Laboratory Medicine, 46(9), 1275-1280.

257 Pagter, P.J. de, Schuurman, R., Visscher, H., Vos, M. de, Bierings, M.B., Loon, A.M. van, Uiterwaal, C.S.P.M., Baarle, D. van, Sanders, E.A.M. & Boelens, J.J. (2008). Human herpes virus 6 plasma DNA

positivity after hematopoietic stem cell transplantation in children: an important risk factor for

clinical outcome. Biology of blood and marrow transplantation, 14(7), 831-839.

258 Patel, A., Cheng, I., Canzian, F., LeMarchand, L., Thun, M.J., Berg, C.D., Buring, J.E., Calle, E.E.,

Chanock, S., Clavel-Chapelon, F., Cox, D.G., Dorronsoro, M., Dossus, L., Haiman, C.A., Hankinson,

S.E., Henderson, B.E., Hoover, R., Hunter, D.J., Kaaks, R., Kolonel, L.N., Kraft, P., Linseisen, J., Lund,

E., Manjer, J., McCarty, C., Peeters, P.H.M., Pike, M.C., Pollak, M., Riboli, E., Stram, D.O., Tjonneland,

A., Travis, R.C., Trichopoulos, D., Tumino, R., Yeager, M., Ziegler, R. & Feigelson, H.S. (2008). IGF-1,

IGFBP-1, and IGFBP-3 polymorphisms predict circulating IGF levels but not breast cancer risk:

findings from the Breast and Prostate Cancer Cohort Consortium (BPC3). PLoS ONE [E], 3(7), 2578.

259 Patel, A., MacMahon, S., Chalmers, J., Neal, B., Billot, L., Woodward, M., Marre, M., Cooper, M.,

Glasziou, P., Grobbee, D.E., Hamet, P., Harrap, S., Heller, S., Liu, L., Mancia, G., Mogensen, C.E., Pan,

C.Y., Poulter, N., Rodgers, A., Williams, B., Bompoint, S, Galan, B.E. de, Joshi, R. & Travert, F. (2008).

Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. New England

Journal of Medicine, 12;358(24), 2560-2572.

260 Patricio, M., Engelsen, C. den, Tseng, D. & Cate, Th.J. ten (2008). State of implementation of the two-

cycle BaMa system in medical education: were do we stand in 2007? Medical Teacher, 30(6), 597-605.

Publications 203

261 Peluso, M., Airoldi, L., Munnia, A., Colombi, A., Veglia, F., Autrup, H., Dunning, A., Garte, S.,

Gormally, E., Malaveille, C., Matullo, G., Overvad, K., Raaschou-Nielsen, O., Clavel-Chapelon, F.,

Linseisen, J., Boeing, H., Trichopoulou, A., Palli, D., Krogh, V., Tumino, R., Panico, S., Bueno-de-

Mesquita, B., Peeters, P.H.M., Kumle, M., Agudo, A, Martinez, C., Dorronsoro, M., Barricarte, A.,

Tormo, M.J., Quiros, J.R., Berglund, G., Jarvholm, B., Day, N.E., Key, T.J., Saracci, R., Kaaks, R., Riboli,

E., Bingham, S & Vineis, P. (2008). Bulky DNA adducts, 4-aminobiphenyl-haemoglobin adducts and

diet in the European Prospective Investigation into Cancer and Nutrition (EPIC) prospective study.

British Journal of Nutrition, 14, 1-7.

262 Peters, N.H., Bosch, M.A.A.J. van den, Peeters, P.H.M., Mali, W.P.T.M. & Borel Rinkes, I.H.M. (2008).

Breast magnetic resonance imaging in early-stage breast cancer: is there really no value? Journal of

Clinical Oncology, 26(20), 3465-3466.

263 Peters, N.H., Borel Rinkes, I.H.M., Zuithoff, N.P.A., Mali, W.P.T.M., Moons, K.G.M. & Peeters, P.H.

(2008). Meta-analysis of MR imaging in the diagnosis of breast lesions. Radiology, 246(1), 116-124.

264 Petrov, M.S., Santvoort, H.C. van, Besselink, M.G.H., Heijden, G.J.M.G. van der, Erpecum, K.J. van &

Gooszen, H.G. (2008). Early endoscopic retrograde cholangiopancreatography versus conservative

management in acute biliary pancreatitis without cholangitis: a meta-analysis of randomized trials.

Annals of Surgery, 247(2), 250-257.

265 Petrov, M.S., Santvoort, H.C. van, Besselink, M.G.H., Heijden, G.J.M.G. van der, Windsor, P.A. &

Gooszen, H.G. (2008). Enteral Nutrition and the Risk of Mortality and Infectious Complications in

Patients With Severe Acute Pancreatitis. Archives of Surgery, 143(11), 1111-1117.

266 Pfefferle, P.I., Sel, S., Johannes, E.M., Buchele, G., Blumer, N., Krauss-Etschmann, S., Herzum, I.,

Albers, C.E., Lauener, R.P., Roponen, M., Hirvonen, M.R., Vuitton, D.A., Riedler, J., Brunekreef, B., Dalphin, J.C., Braun-Fahrlander, C., Pekkanen, J., von Mutius, E. & Renz, H. (2008). Cord blood

allergen-specific IgE is associated with reduced IFN-gamma production by cord blood cells: The

Protection against Allergy-Study in Rural Environments (PASTURE) study. Journal of Allergy and

Clinical Immunology, 122(4), 711-716.

267 Pischon, T., Boeing, H., Hoffmann, K., Bergmann, M., Schulze, M.B., Overvad, K., Schouw, Y.T. van der, Spencer, E., Moons, K.G.M., Tjonneland, A., Halkjaer, J., Jensen, M.K., Stegger, J., Clavel-

Chapelon, F., Boutron-Ruault, M.C., Chajes, V., Linseisen, J., Kaaks, R., Trichopoulou, A.,

Trichopoulos, D., Bamia, C., Sieri, S., Palli, D., Tumino, R., Vineis, P., Panico, S., Peeters, P.H.M., May, A.M., Bueno-de-Mesquita, H.B., Duijnhoven, F.J.B van, Hallmans, G., Weinehall, L., Manjes, J.,

Hedblad, B., Lund, E., Agudo, A, Arriola, L., Barricarte, A., Navarro, C., Martinez, C., Quiros, J.R., Key,

T.J., Bingham, S, Khaw, K.T., Boffetta, P., Jenab, M., Ferrari, P. & Riboli, E. (2008). General and

abdominal adiposity and risk of death in Europe. New England Journal of Medicine, 359(20), 2105-

2120.

268 Plug, I., Peters, M., Mauser-Bunschoten, E.P., Goede-Bolder, A. de, Heijen, L., Smit, C., Willemse, J.,

Rosendaal, F.R. & Bom, J.G. van der (2008). Social participation of patients with hemophilia in the

Netherlands. Blood, 111(4), 1811-1815.

269 Posthouwer, D., Mauser-Bunschoten, E.P. & Fischer, K. (2008). Liver biopsy in patients with

haemophilia; in search for a reliable, non-invasive alternative. Haemophilia, 14, 647-648.

270 Pruissen, D.M.O., Slooter, A.J.C., Rosendaal, F.R., Graaf, Y. van der & Algra, A. (2008). Coagulation

factor XIII gene variation, oral contraceptives and risk of ischemic stroke. Blood, 111(3), 1282-1286.

271 Pruissen, D.M.O., Rosendaal, F.R., Frijns, C.J.M., Kappelle, L.J., Vos, H.L. & Algra, A. (2008).

Prothrombotic gene variation and new vascular events after cerebral ischemia of arterial origin.

Journal of Thrombosis and Haemostasis, 6(10), 1639-1644.

272 Pruissen, D.M.O., Kappelle, L.J., Rosendaal, F.R., Moll, F.L., Algra, A. & SMART, Study (2008).

Prothrombotic gene variation in patients with large and small vessel disease. Neuroepidemiology,

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273 Putte, E.M. van de, Böcker, K.B.E., Buitelaar, J., Kenemans, J.L., Engelbert, R.H.H., Kuis, W., Kimpen,

J.L.L. & Uiterwaal, C.S.P.M. (2008). Deficits of interference control in adolescents with chronic

fatigue syndrome. Archives of pediatrics & adolescent medicine, 162(12), 1196-1197.

274 Quanjer, P.H., Borsboom, G.J.J.M., Kivastik, J., Merkus, P.J.F.M., Hankinson, J.L., Houthuijs, D.,

Brunekreef, B., Ihorst, G. & Kühr, J. (2008). Cross-sectional and Longitudinal Spirometry in Children

and Adolescents: Interpretative Strategies. American Journal of Respiratory and Critical Care

Medicine, 178(12), 1262-1270.

275 Raaijmakers, M.A.J., Koffijberg, H., Posthumus, J.A., Hout, B.A. van, Engeland, H. van & Matthys,

W.C.H.J. (2008). Assessing performance of a randomized versus a non-randomized study design.

Contemporary Clinical Trials, 29(2), 293-303.

276 Rademaker, K.J., Vries, L.S. de, Uiterwaal, C.S.P.M., Groenendaal, F., Grobbee, D.E. & Bel, F. van

(2008). Postnatal hydrocortisone treatment for chronic lung disease in the preterm newborn and

long-term neurodevelopmental follow-up. Archives of Disease in Childhood Fetal and Neonatal

Edition, 93(1), 58-63.

277 Regieli, J.J., Jukema, J.W., Grobbee, D.E., Kastelein, J.J.P., Kuivenhoven, J.A., Zwinderman, A.H., Graaf, Y. van der, Bots, M.L. & Doevendans, P.A.F.M. (2008). CETP genotype predicts increased mortality in

statin-treated men with proven cardiovascular disease: An adverse pharmacogenetic interaction.

European Heart Journal, 29(22), 2792-2799.

278 Regt, M.J.A. de, Wagen, L.E. van der, Top, J., Blok, H.E.M., Hopmans, T.E.M., Dekker, A.W., Hene, R.J.,

Siersema, P.D., Willems, R.J.L. & Bonten, M.J.M. (2008). High acquisition and environmental

contramination rates of CC17 ampicillin-resistant Enterococcus faecium in a Dutch hospital. Journal

of Antimicrobial Chemotherapy, 62(6), 1401-1406.

279 Rietjens, J.A.C., Delden, J.J.M. van, Onwuteaka-Philipsen, B.D., Buiting, H.M., Maas, P.J. van der &

Heide, A. van der (2008). Continuous deep sedation for patients nearing death in the Netherlands:

descriptive study. British Medical Journal, 336(7648), 810-813.

280 Rijen, MML van, Bonten, M.J.M., Wenzel, R.P. & Kluytmans, J.A.J.W. (2008). Intranasal mupirocin

for reduction of Staphylococcus aureus infections in surgical patients with nasal carriage: a systematic

review. Journal of Antimicrobial Chemotherapy, 61(2), 254-261.

281 Rijen, MML van, Bonten, M.J.M., Wenzel, R.P. & Kluytmans, J.A.J.W. (2008). Mupirocin ointment for

preventing Staphylococcus aureus infections in nasal carriers. The Cochrane Database of Systematic

Reviews [E], 4, CD006216.

282 Rijn, M. van, Jansma, J., Brinksma, A., Bakker, H.D., Boers, G.H.J., Carbasius Weber, E.C., Douwes,

A.C., Herberg, A. van den, Horst, N.M. ter, Klerk, J.B.C. de, Koning, T.J. de, Ploeg, L. van den, Rubio-

Gozalbo, M.E., Sels, J.P., Sengers, R.C.A., Valk, H.W. de, Termeulen, H., Zweers, H. & Spronsen, F.J.

van (2008). A survey of natural protein intake in Dutch phenylketonuria patients: insight into

estimation or measurement of dietary intake. Journal of the American Dietetic Association, 108(10),

1704-1707.

283 Rinaldi, S., Rohrmann, S., Jenab, M., Biessy, C., Sieri, S., Palli, D., Tumino, R., Mattiello, A., Vineis, P.,

Nieters, A., Linseisen, J., Pischon, T., Boeing, H., Hallmans, G., Palmqvist, R., Manjer, J., Wirfalt, E.,

Crowe, F., Khaw, K.T., Bingham, S, Tjonneland, A., Olsen, A., Overvad, K., Lund, E., Skeie, G., Clavel-

Chapelon, F., Boutron-Ruault, M.C., Lauzon-Guillain, B., Ardanaz, E., Jakszyn, P., Quiros, J.R.,

Chirlaque, M.D., Sanchez, M.J., Dorronsoro, M., Trichopoulou, A., Lagiou, P., Trichopoulos, D.,

Bueno-de-Mesquita, H.B., Duijnhoven, F.J.B van, Peeters, P.H.M., Slimani, N., Ferrari, P., Byrnes, G.B., Riboli, E. & Kaaks, R. (2008). Glycosylated hemoglobin and risk

of colorectal cancer in men and women, the European prospective investigation into cancer and

nutrition. Cancer Epidemiology Biomarkers & Prevention, 17(11), 3108-3115.

284 Rodriguez, J.A., Hellings, W.E., Moll, F.L., Vries, J.P.P.M. de, Middelaar, B.J. van, Algra, A., Sluijter,

J.P.G., Velema, E., Broek, T. van den, Sessa, W.C., Kleijn, D.P.V. de & Pasterkamp, G. (2008). Caveolin-1

influences vascular protease activity and is a potential stabilizing factor in human atherosclerotic

disease. PLoS ONE [E], 3(7), e2612/1-e2612/12.

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285 Roos, K., Meijs, M.F.L., Vos, A.M. de, Rutten, A., Doevendans, P.A.F.M., Schouw, Y.T. van der, Prokop,

W.M., Bots, M.L. & Vonken, E.P.A. (2008). Myocardial adipose tissue in healthy postmenopausal

women: no relations with vascular risk. European Journal of Clinical Investigation, 38(10), 786-787.

286 Roukema, J., Loenhout, R.B. van, Steyerberg, E.W., Moons, K.G.M., Bleeker, S.E. & Moll, H.A. (2008).

Polytomous regression did not outperform dichotomous logistic regression in diagnosing serious

bacterial infections in febrile children. Journal of Clinical Epidemiology, 61(2), 135-141.

287 Rovers, M.M., Numans, M.E., Langenbach, E., Grobbee, D.E., Verheij, Th.J.M. & Schilder, A.G.M.

(2008). Is pacifier use a risk factor for acute otitis media? A dynamic cohort study. Family Practice,

25(4), 233-236.

288 Ruskamp, J.M., Hoekstra, M.O., Postma, D.S., Kerkhof, M., Bottema, R.W.B., Koppelman, G.H.,

Rovers, M.M., Wijga, A.H., Jongste, J.C. de, Brunekreef, B. & Sanders, E.A.M. (2008). Exploring the

role of polymorphisms in ficolin genes in respiratory tract infections in children. Clinical and

Experimental Immunology, 155, 433-440.

289 Ruskamp, J.M., Hoekstra, M.O., Postma, D.S., Kerkhof, M., Bottema, R.W.B., Koppelman, G.H.,

Rovers, M.M., Wijga, A.H., Jongste, J.C. de, Brunekreef, B. & Sanders, E.A.M. (2008). Polymorphisms

in the mannan-binding lectin gene are not associated with questionnaire-reported respiratory tract

infections in children. Journal of Infectious Diseases, 198(11), 1707--13.

290 Rutten, F.H. & Hoes, A.W. (2008). B-type natriuretic peptide assays for detecting heart failure in the

elderly: same value as those in the younger? International Journal of Cardiology, 125(2), 161-165.

291 Rutten, F.H., Vonken, E.P.A., Cramer, M.J.M., Moons, K.G.M., Velthuis, B., Prakken, N.H.J., Lammers,

J.W.J., Grobbee, D.E., Mali, W.P.T.M. & Hoes, A.W. (2008). Cardiovascular magnetic resonance

imaging to identify left-sided chronic heart failure in stable patients with chronic obstructive

pulmonary disease. American Heart Journal, 156(3), 506-512.

292 Sabour, S., Atsma, F., Rutten, A., Grobbee, D.E., Mali, W.P.T.M., Prokop, W.M. & Bots, M.L. (2008).

Multi Detector-Row Computed Tomography (MDCT) had excellent reproducibility of coronary

calcium measurements. Journal of Clinical Epidemiology, 61(6), 572-579.

293 Scheffer, A., Rooij, S.E., Hooft, T. van ‘t & Schuurmans, M.J. (2008). Fear of falling: measurement

strategy, prevalence, risk factors and consequences among older persons: a systematic review.r. Age

and Ageing, 37(1), 19-24.

294 Scheltens, T., Verschuren, W.M., Boshuizen, H.C., Hoes, A.W., Zuithoff, N.P.A., Bots, M.L. &

Grobbee, D.E. (2008). Estimation of cardiovascular risk: a comparison between the Framingham and

the SCORE model in people under 60 years of age. European Journal of Cardiovascular Prevention

and Rehabilitation, 15(5), 562-566.

295 Schlösser, F.J.V., Tangelder, M.J., Verhagen, H.J., Heijden, G.J.M.G. van der, Muhs, B.E., Graaf, Y. van der, Moll, F.L. & SMART, Study Group (2008). Growth predictors and prognosis of small abdominal

aortic aneurysms [Smart Study Group]. Journal of Vascular Surgery, 47, 1127-1133.

296 Schlösser, F.J.V., Heijden, G.J.M.G. van der, Graaf, Y. van der, Moll, F.L. & Verhagen, H.J.M. (2008).

Predictors of adverse events after endovascular abdominal aortic aneurysm repair. A meta-analysis of

case reports. Journal of Medical Case Reports [E], 2(1), 303-303.

297 Scholtens, S., Brunekreef, B., Smit, H.A., Gast, G.C.M., Hoekstra, M.O., Jongste, J.C. de, Postma, D.S.,

Gerritsen, J., Seidell, J.C. & Wijga, A.H. (2008). Do differences in childhood diet explain the reduced

overweight risk in breastfed children? Obesity (Silver Spring), 16(11), 2498-2503.

298 Schreinemakers, J.M.J., Elias, S.G. & Borel Rinkes, I.H.M. (2008). Retroperitoneal endoscopic versus

conventional open adrenalectomy: a cost-effectiveness analysis. Journal of Laparoendoscopic Surgery

& Advanced Surgical Techniques. Part A., 18(5), 707-712.

299 Schryver, E.L.L.M. de, Algra, A. & Gijn, J. van (2008). Dipyridamole for preventing stroke and other

vascular events in patients with vascular disease: an update. Stroke, 39(4), 1397-1398.


300 Seifert, B., Rubin, G., Wit, N.J. de, Lionis, C., Hall, N., Hungin, P., Jones, R., Palka, M. & mendive, J

(2008). The management of common gastrointestinal disorders in general practice. A survey by the

European Society for Primary Care Gastroenterology (ESPCG) in six European countries. Digestive

and liver disease, 40(8), 659-666.

301 Siccama, R.N., Janssen, K.J.M., Oudega, R., Delden, J.J.M. van & Moons, K.G.M. (2008). D-dimer

testing in elderly patients in primary care for exclusion of venous thromboembolism. Journal of

Thrombosis and Haemostasis, 6(11), 1972-1973.

302 Sieri, S., Krogh, V., Berrino, F., Pala, V., Thiebaut, A., Tjonneland, A., Olsen, A., Overvad, K., Jakobsen,

M.U., Clavel-Chapelon, F., Chajes, V., Boutron-Ruault, M.C., Kaaks, R., Linseisen, J., Boeing, H.,

Nothlings, U., Trichopoulou, A., Naska, A., Lagiou, P., Panico, S., Palli, D., Vineis, P., Tumino, R., Lund,

E., Kumle, M., Skeie, G., Gonzalez, C.A., Ardanaz, E., Amiano, P., Tormo, M.J., Martinez-Garcia, C.,

Quiros, J.R., Berglund, G., Gullberg, B., Hallmans, G., Lenner, P., Bueno-de-Mesquita, H.B.,

Duijnhoven, F.J.B van, Peeters, P.H.M., Gils, C.H. van, Key, T.J., Crowe, F., Bingham, S, Khaw, K.T.,

Rinaldi, S., Slimani, N., Jenab, M., Norat, T. & Riboli, E. (2008). Dietary fat and breast cancer risk in

the European Prospective Investigation into Cancer and Nutrition. American Journal of Clinical

Nutrition, 88(5), 1304-1312.

303 Sliedrecht, A., Elzen, W.P. den, Verheij, Th.J.M., Westendorp, R.G.J. & Gussekloo, J. (2008). Incidence

and predictive factors of lower respiratory tract infections among the very elderly in the general

population. The Leiden 85-plus Study. Thorax, 63(9), 817-822.

304 Smeets, R.J., Vlaeyen, J.W.S., Hidding, A., Kester, A.D., Heijden, G.J.M.G. van der, Geel, A.C. van &

Knottnerus, prof.dr. J.A. (2008). Active rehabilitation for chronic low back pain: cognitive-behavioral,

physical, or both? First direct post-treatment results from a randomized controlled trial. BMC

Musculoskeletal Disorders [E], 20(7), 5.

305 Smeets, R.J., Vlaeyen, J.W.S., Hidding, A., Kester, A.D.M., Heijden, G.J.M.G. van der & Knottnerus,

J.A. (2008). Chronic low back pain: Physical training, graded activity with problem solving training,

or both? The one-year post-treatment results of a randomized controlled trial. Pain, 134(3), 263-276.

306 Smet, A.M.G.A. de & Bonten, M.J.M. (2008). Selective decontamination of the digestive tract. Current

Opinion in Infectious Diseases, 21(2), 179-183.

307 Smulders, Y.M., Burgers, J.S., Scheltens, T., Hout, B.A. van, Wiersma, T. & Simoons, M.L. (2008).

Clinical practice guideline for cardiovascular risk management in the Netherlands. Netherlands

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308 Soedamah-Muthu, S.S, Chaturvedi, N., Pickup, J.C. & Fuller, J.H. (2008). Relationship between

plasma sialic acid and fibrinogen concentration and incident micro- and microvascular complications

in type 1 diabetes. The EURODIAB Prospective Complications Study (PCS)). Diabetologia, 51(3),

493-501.

309 Soedamah-Muthu, S.S, Visseren, F.L.J., Algra, A., Graaf, Y. van der & SMART, Study (2008). The

impact of Type 2 diabetes and microalbuminuria on future cardiovascular events in patients with

clinically manifest vascular disease from the Second Manifestations of ARTerial disease (SMART)

study. Diabetic Medicine, 25(1), 51-57.

310 Sol, B.G., Graaf, Y. van der, Bijl, J.J. van der, Goessens, B.M.B. & Visseren, F.L.J. (2008). The role of

self-efficacy in vascular risk factor management: a randomized controlled trial. Patient Education and

Counseling, 71(2), 191-197.

311 Stadhouder, A., Oner, F.C., Wilson, K.W., Vaccaro, A.R., Williamson, O.D., Verbout, A.J., Verhaar, J.A.,

Klerk, L.W.L. de & Buskens, E. (2008). Surgeon equipoise as an inclusion criterion for the evaluation

of nonoperative versus operative treatment of thoracolumbar spinal injuries. Spine Journal, 8(6), 975-

981.

312 Stadhouder, A., Buskens, E., Klerk, L.W.L. de, Verhaar, J.A., Dhert, W.J.A., Verbout, A.J., Vaccaro, A.R.

& Oner, F.C. (2008). Traumatic thoracic and lumbar spinal fractures: operative or nonoperative

treatment: comparison of two treatment strategies by means of surgeon equipoise. Spine, 33(9), 1006-

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Publications 207

313 Stolk, R.P., Schooneveld, M.J. van, Cruickshank, J.K., Hughes, A, Stanton, A, Lu, J., Patel, A., Thom,

S.A., Grobbee, D.E. & Vingerling, J.R. (2008). Retinal vascular lesions in patients of Caucasian and

Asian origin with type 2 diabetes: baseline results from the ADVANCE Retinal Measurements

(AdRem) study. Diabetes Care, 31(4), 708-713.

314 Störk, S., Bots, M.L., Grobbee, D.E. & Schouw, Y.T. van der (2008). Endogenous sex hormones and

C-reactive protein in healthy postmenopausal women. Journal of Internal Medicine, 264(3), 245-253.

315 Stringer, B., Meijel, B.K.G. van, Vree, W. de & Bijl, J.J. van der (2008). User involvement in mental

health care: the role of nurses. A literature review. Journal of Psychiatric and Mental Health Nursing,

15(8), 678-683.

316 Strohaber, J. & Uiterwaal, C.S.P.M. (2008). In situ measurement of three-dimensional ion densities in

focused femtosecond pulses. Physical review letters, 100((2)), 023002.

317 Stuifbergen, M.C., Delden, J.J.M. van & Dykstra, P.A. (2008). The implications of today’s family

structures for support giving to older parents. Ageing and society, 28, 413-434.

318 Suijkerbuijk, K.P.M., Fackler, M.J., Sukumar, S., Gils, C.H. van, Laar, T. van, Wall, E. van der, Vooijs,

M.A.G.G. & Diest, P.J. van (2008). Methylation is less abundant in BRCA1-associated compared with

sporadic breast cancer. Annals of Oncology, 19(11), 1870-1874.

319 Summeren, M.J.H. van, Hameleers, M., Schurgers, L.J., Hoeks, A.P., Uiterwaal, C.S.P.M., Kruger, T.,

Vermeer, C., Kuis, W. & Lilien, M.R. (2008). Circulating calcification inhibitors and vascular

properties in children after renal transplantation. Pediatric Nephrology, 23(6), 985-993.

320 Summeren, M.J.H. van, Vermeer, C., Engelbert, R.H.H., Schurgers, L.J., Takken, T., Fischer, K. & Kuis,

W. (2008). Extremes in vitamin K status of bone are related to bone ultrasound properties in children

with juvenile idiopathic arthritis. Clinical and Experimental Rheumatology, 26(3), 484-491.

321 Summeren, M.J.H. van, Coeverden, S.C. van, Schurgers, L.J., Braam, L.A., Noirt, F., Uiterwaal, C.S.P.M., Kuis, W. & Vermeer, C. (2008). Vitamin K status is associated with childhood bone mineral

content. British Journal of Nutrition, 100(4), 852-858.

322 Sutton, A., Hope, V.D., Mathei, C., Mravcik, V., Sebakova, H., Vallejo, F., Suligoi, B., Brugal, M.T.,

Ncube, F., Wiessing, L.G. & Kretzschmar, M.E.E. (2008). A comparison between the force of infection

estimates for blood-borne viruses in injecting drug user populations across the European Union: a

modelling study. Journal of Viral Hepatitis, 15(11), 809-816.

323 Thiel, G.J.M.W. van & Delden, J.J.M. van (2008). Phase IV research: innovation in need of ethics.

Journal of Medical Ethics, 34(6), 415-416.

324 Thoolen, B.J., Ridder, D.T.D. de, Bensing, J., Gorter, K.J. & Rutten, G.E.H.M. (2008). Beyond Good

Intentions: the development and evaluation of a proactive self-management course for patients

recently diagnosed with Type 2 diabetes. Health Education Research, Feb(23), 53-61.

325 Tiehuis, A.M., Vincken, K.L., Mali, W.P.T.M., Kappelle, L.J., Anbeek, P., Algra, A. & Biessels, G.J.

(2008). Automated and visual scoring methods of cerebral white matter hyperintensities: relation

with age and cognitive function. Cerebrovascular Diseases, 25(1-2), 59-66.

326 Tiehuis, A.M., Graaf, Y. van der, Visseren, F.L.J., Vincken, K.L., Biessels, G.J., Appelman, A.P.A., Kappelle, L.J., Moll, F.L., Mali, W.P.T.M. & SMART, Study Group (2008). Diabetes increases atrophy

and vascular lesions on brain MRI in patients with symptomatic arterial disease. Stroke, 39(5), 1600-

1603.

327 Tjang, Y.S., Heijden, G.J.M.G. van der, Tenderich, G., Korfer, R. & Grobbee, D.E. (2008). Impact of

recipient’s age on heart transplantation outcome. Annals of Thoracic Surgery, 85(6), 2051-2055.

328 Tjang, Y.S., Heijden, G.J.M.G. van der, Tenderich, G., Grobbee, D.E. & Korfer, R. (2008). Survival

analysis in heart transplantation: results from an analysis of 1290 cases in a single center. European

Journal of Cardio-Thoracic Surgery, 33(5), 856-861.

329 Toll, D.B., Oudega, R., Vergouwe, Y., Moons, K.G.M. & Hoes, A.W. (2008). A new diagnostic rule for

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330 Toll, D.B., Janssen, K.J.M., Vergouwe, Y. & Moons, K.G.M. (2008). Validation, updating and impact

of clinical prediction rules: a Review. Journal of Clinical Epidemiology, 61, 1085-1094.

331 Top, J., Banga, J.D., Hayes, R, Willems, R.J.L., Bonten, M.J.M. & Hayden, M.K. (2008). Comparison of

multiple-locus variable-number tandem repeat analysis and pulsed-field gel electrophoresis in a

setting of polyclonal endemicity of vancomycin-resistant Enterococcus faecium. Clinical

Microbiology and Infection, 14(4), 363-369.

332 Top, J., Willems, R.J.L. & Bonten, M.J.M. (2008). Emergence of CC17 Enterococcus faecium: from

commensal to hospital-adapted pathogen. FEMS Immunology and Medical Microbiology, 52(3), 297-

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333 Top, J., Willems, R.J.L., Velden, S., Asbroek, M. & Bonten, M.J.M. (2008). Emergence of clonal

complex 17 Enterococcus faecium in The Netherlands. Journal of Clinical Microbiology, 46(1), 214-

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334 Trappenburg, J.C.A., Niessink, A., Weert-van Oene, G.H. de, Zeijden, H., Snippenburg, R. van, Peters,

A., Lammers, J.W.J. & Schrijvers, A.J.P. (2008). Effects of Telemonitoring in patients with Chronic

Obstructive Pulmonary disease. Telemedicine Journal and e-Health, 14(2), 138-146.

335 Uijen, J.H.J.M., Duijn, H.J. van, Kuyvenhoven, M.M., Schellevis, F.G. & Wouden, J.C. van der (2008).

Characteristics of children consulting for cough, sore throat, or earache. British Journal of General

Practice, 58(549), 248-254.

336 Uijl, I.E.M. den & Fischer, K. (2008). Including the life-time cumulative number of joint bleeds in the

definition of primary prophylaxis. Thrombosis and Haemostasis, 99, 965-968.

337 Uijl, S.G., Moons, K.G.M., Leijten, F.S.S., Veltman, E.P.H.M., Budde, A. & Donselaar, C.A. van (2008).

Is epilepsy surgery utilized to its full extent? Epilepsia, 49(8), 1480-1481.

338 Uijl, S.G., Leijten, F.S.S., Arends, J.B.A.M., Parra, J, Huffelen, A.C. van & Moons, K.G.M. (2008).

Prognosis after temporal lobe epilepsy surgery: the value of combining predictors. Epilepsia, 49(8),

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339 Vaartjes, C.H., Reitsma, J.B., Bruin, A. de, Berger-van Sijl, M., Bos, M.J., Breteler, M.M., Grobbee, D.E. & Bots, M.L. (2008). Nationwide incidence of first stroke and TIA in the Netherlands. European

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340 Vachon, C.M., Gils, C.H. van, Sellers, T.A., Ghosh, K., Pruthi, S., Brandt, K.R. & Pankratz, V.S. (2008).

Mammographic density, breast cancer risk and risk prediction. Breast Cancer Research, 9(6), 217.

341 Vahanian, A., Alfieri, O.R., Al-Attar, N., Antunes, M.J., Bax, J., Cormier, B., Cribier, A., Jaegere, P.P.T.

de, Fournial, G., Kappetein, A.P., Kovac, J., Ludgate, S., Maisano, F., Moat, N., Mohr, F.W., Nataf, P.,

Pierard, L., Pomar, J.L., Schofer, J., Tornos, P., Tuzcu, M., Hout, B.A. van, Segesser, L.K. Von & Walther,

T. (2008). Transcatheter valve implantation for patients with aortic stenosis: a position statement

from the European Association of Cardio-Thoracic Surgery (EACTS) and the European Society of

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342 European Journal of Cardio-Thoracic Surgery, 34(1), 1-8.

343 European Heart Journal, 29, 1463-1470.

344 EuroIntervention. 2008 Aug;4(2):193-9.

345 Van Roosbroeck, S., Li, R., Hoek, G., Lebret, E., Brunekreef, B. & Spiegelman, D. (2008). Traffic-

related outdoor air pollution and respiratory symptoms in children: the impact of adjustment for

exposure measurement error. Epidemiology, 19(3), 409-416.

346 Van Roosbroeck, S., Hoek, G., Meliefste, K., Janssen, N.A.H. & Brunekreef, B. (2008). Validity of

residential traffic intensity as an estimate of long-term personal exposure to traffic-related air

pollution among adults. Environmental Science and Technology, 42(4), 1337-1344.

347 Velden, A.W. van der, Wit, N.J. de, Quartero, A.O., Grobbee, D.E. & Numans, M.E. (2008).

Maintenance treatment for GERD: residual symptoms are associated with psychological distress.

Digestion, 77(3-4), 207-213.

Publications 209

348 Ven, S.M.W.Y. van de, Elias, S.G., Bosch, M.A.A.J. van den, Luijten, P.R. & Mali, W.P.T.M. (2008).

Optical imaging of the breast. Cancer Imaging, 8, 206-215.

349 Venmans-Muller, L.M.A.J., Bont, J., Gorter, K.J., Verheij, Th.J.M., Rutten, G.E.H.M. & Hak, E. (2008). Prediction of complicated lower respiratory tract infections in older patients with diabetes.

British Journal of General Practice, 58(553), 564-568.

350 Vergeer, M., Bots, M.L., Leuven, S.I. van, Basart, D.C., Sijbrands, E.J., Evans, G.W., Grobbee, D.E., Visseren, F.L.J., Stalenhoef, A.F., Stroes, E.S.G. & Kastelein, J.J.P. (2008). Cholesteryl ester transfer

protein inhibitor torcetrapib and off-target toxicity: a pooled analysis of the rating atherosclerotic

disease change by imaging with a new CETP inhibitor (RADIANCE) trials. Circulation, 118(24),

2515-2522.

351 Vergouwe, Y., Klei, W.A. van, Kalkman, C.J. & Moons, K.G.M. (2008). Propensity scores do not

necessarily lie! Anesthesiology, 109(4), 746-747.

352 Vergouwe, Y. & Steyerberg, E.W. (2008). Re: Axel Heidenreich, David Thüer, Sergej Polyakov.

Postchemotherapy retroperitoneal lymph node dissection in advanced germ cell tumours of the testis.

Eur Urol 2008; 53: 260-74. European Urology, 2008(54(4)), 954-955.

353 Verheij, Th.J.M. (2008). De huisarts staat niet met lege handen. Huisarts en Wetenschap, 51(4), 166.

354 Verheugt, C.L., Uiterwaal, C.S.P.M., Velde, E.T. van der, Meijboom, F.J., Pieper, P.G., Vliegen, H.W.,

Dijk, A.P.J. van, Bouma, B.J, Grobbee, D.E. & Mulder, B.J.M. (2008). Gender and outcome in adult

congenital heart disease. Circulation, 118(1), 26-32.

355 Verheugt, C.L., Uiterwaal, C.S.P.M., Grobbee, D.E. & Mulder, B.J.M. (2008). Long-term prognosis of

congenital heart defects: a systematic review. International Journal of Cardiology, 131(1), 25-32.

356 Verheus, M., McKay, J.D., Kaaks, R., Canzian, F., Biessy, C., Johansson, M., Grobbee, D.E., Peeters, P.H.M. & Gils, C.H. van (2008). Common genetic variation in the IGF-1 gene, serum IGF-I levels and

breast density. Breast Cancer Research and Treatment, 112(1), 109-122.

357 Verheus, M., Gils, C.H. van, Kreijkamp-Kaspers, S., Kok, L., Peeters, P.H.M., Grobbee, D.E. &

Schouw, Y.T. van der (2008). Soy protein containing isoflavones and mammographic density in a

randomized controlled trial in postmenopausal women. Cancer Epidemiology Biomarkers &

Prevention, 17(10), 2632-2638.

358 Verkooijen, H.M., Koot, V.C.M., Fioretta, G., Heiden, M. van der, Schipper, M.E.I., Rapiti, E., Peeters, P.H.M., Peterse, J.L. & Bouchardy, C. (2008). Hormone replacement therapy, mammography

screening and changing age-specific incidence rates of breast cancer: an ecological study comparing

two European populations. Breast Cancer Research and Treatment, 107(3), 389-395.

359 Vernooij, F., Heintz, A.P.M., Witteveen, P.O., Heiden-van der Loo, M. van der, Coebergh, J.W. & Graaf, Y. van der (2008). Specialized care and survival of ovarian cancer patients in The Netherlands:

nationwide cohort study. Journal of the National Cancer Institute, 100(6), 399-406.

360 Vesper, H.W., Slimani, N., Hallmans, G., Tjonneland, A., Agudo, A, Benetou, V., Bingham, S, Boeing,

H., Boutron-Ruault, M.C., Bueno-de-Mesquita, H.B., Chirlaque, M.D., Clavel-Chapelon, F., Crowe, F.,

Drogan, D., Ferrari, P., Johansson, I., Kaaks, R., Linseisen, J., Lund, E., Manjer, J., Mattiello, A., Palli,

D., Peeters, P.H.M., Rinaldi, S., Skeie, G., Trichopoulou, A., Vineis, P., Wirfalt, E., Overvad, K. &

Stromberg, U. (2008). Cross-Sectional Study on Acrylamide Hemoglobin Adducts in Subpopulations

from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study. Journal of

Agricultural and Food Chemistry, 56(15), 6046-6053.

361 Visscher, S., Schurink, C.A.M., Melsen, W.G., Lucas, P.J.F. & Bonten, M.J.M. (2008). Effects of

systemic antibiotic therapy on bacterial persistence in the respiratory tract of mechanically ventilated

patients. Intensive Care Medicine, 34(4), 692-699.

362 Visscher, S., Kruisheer, E.M., Schurink, C.A.M., Lucas, P.J.F. & Bonten, M.J.M. (2008). Predicting

pathogens causing ventilator-associated pneumonia using a Bayesian network model. Journal of

Antimicrobial Chemotherapy, 62(1), 184-188.


363 Vlek, A.L.M., Graaf, Y. van der, Spiering, W., Algra, A., Visseren, F.L.J., Doevendans, P.A., Grobbee, D.E., Kappelle, L.J., Mali, W.P.T.M., Moll, F.L. & Rutten, G.E.H.M. (2008). Cardiovascular events and

all-cause mortality by albuminuria and decreased glomerular filtration rate in patients with vascular

disease. Journal of Internal Medicine, 264(4), 351-360.

364 Vlek, A.L.M., Graaf, Y. van der, Moll, F.L., Spiering, W., Visseren, F.L.J. & SMART, Study Group

(2008). Effect of metabolic syndrome or type II diabetes mellitus on the occurrence of recurrent

vascular events in hypertensive patients [Smart Study Group]. Journal of human hypertension, 22,

358-365.

365 Vliet-Ostaptchouk, J.V. van, Onland-Moret, N.C., Haeften, T.W. van, Franke, L.H., Elbers, C.C., Shiri-

Sverdlov, R., Schouw, Y.T. van der, Hofker, M. & Wijmenga, C. (2008). HHEX gene polymorphisms

are associated with type 2 diabetes in the Dutch Breda cohort. European Journal of Human Genetics,

16(5), 652-656.

366 Vliet-Ostaptchouk, J.V. van, Onland-Moret, N.C., Shiri-Sverdlov, R., Gorp, P.J. van, Custers, A.,

Peeters, P.H.M., Wijmenga, C., Hofker, M.H. & Schouw, Y.T. van der (2008). Polymorphisms of the

TUB gene are associated with body composition and eating behavior in middle-aged women. PLoS

ONE [E], 3(1), e1405.

367 Vlimmeren, L.A. van, Graaf, Y. van der, Boere-Boonekamp, M.M., L’Hoir, M.P., Helders, P.J.M. &

Engelbert, R.H.H. (2008). Effect of Pediatric Physical Therapy on Deformational Plagiocephaly in

Children With Positional Preference. Archives of pediatrics & adolescent medicine, 162(8), 712-718.

368 Vos, A.M. de, Rutten, A., Zaag, H.J. van der, Bots, M.L., Dikkers, R., Buiskool, R.A., Mali, W.P.T.M.,

Lubbers, D.D., Mosterd, A., Prokop, W.M., Rensing, B.J., Cramer, M.J.M., Es, H.W. van, Moll, F.L.,

Pavoordt, E.D. van de, Doevendans, P.A.F.M., Velthuis, B.K., Mackaay, A.J., Zijlstra, F.J. & Oudkerk, M.

(2008). Non-invasive cardiac assessment in high risk patients (the ground study): Rationale,

objectives and design of a multi-center randomized controlled clinical trial. Trials [E], 9(1), 49-49.

369 Vos, A.M. de, Prokop, W.M., Roos, C.J., Meijs, M.F.L., Schouw, Y.T. van der, Rutten, A., Gorter, P.,

Cramer, M.J.M., Doevendans, P.A.F.M., Rensing, B.J., Bartelink, M.E.L., Velthuis, B.K., Mosterd, A. &

Bots, M.L. (2008). Peri-coronary epicardial adipose tissue is related to cardiovascular risk factors and

coronary artery calcification in post-menopausal women. European Heart Journal, 29(6), 777-783.

370 Voskuil, D.W., Vrieling, A., Korse, C.M., Beijnen, J.H., Bonfrer, J.M.G., Doorn, J. van, Kaas, R.,

Oldenburg, H.S.A., Russell, N.S., Rutgers, E.J.T., Verhoef, S., Leeuwen, F.E. van, Veer, L.J. van ‘t &

Rookus, M.A. (2008). Effects of lycopene on the insulin-like growth factor (IGF) system in

premenopausal breast cancer survivors and women at high familial breast cancer risk. Nutrition and

Cancer-an International Journal, 60(3), 342-353.

371 Vrieling, A., Rookus, M.A., Kampman, E., Bonfrer, J.M.G., Bosma, A., Cats, A., Doorn, J. van, Korse,

C.M., Witteman, B.J., Leeuwen, F.E. van, Veer, L.J. van ‘t & Voskuil, D.W. (2008). No effect of red

clover-derived isoflavone intervention on the insulin-like growth factor system in women at increased

risk of colorectal cancer. Cancer Epidemiology Biomarkers & Prevention, 17(10), 2585-2593.

372 Wassink, A.M.J., Graaf, Y. van der, Moll, F.L., Soedamah-Muthu, S.S., Spiering, W. & Visseren, F.L.J.

(2008). Metabolic Syndrome and incidence of type 2 diabetes in patients with manifest vascular

disease [Smart Study Group]. Diabetes and Vascular Disease Research, 5(2), 114-122.

373 Wassink, A.M.J., Graaf, Y. van der, Olijhoek, J.K., Visseren, F.L.J., Moll, F.L. & SMART, Study Group

(2008). Metabolic syndrome and the risk of new vascular events and all-cause mortality in patients

with coronary artery disease, cerebrovascular disease, peripheral arterial disease or abdominal aortic

aneurysm. European Heart Journal, 29(2), 213-223.

374 Weerd, M. de, Buskens, E. & Bots, M.L. (2008). Guidelines for screening of extracranial carotid artery

disease: a comment. Journal of Neuroimaging, 18(1), 105-106.

375 Weerd, N.C. van der, Penne, E.L., Dorpel, M.A. van den, Grooteman, M.P.C., Nube, M.J., Bots, M.L., Wee ter, P.M & Blankestijn, P.J. (2008). Haemodiafiltration: promise for the future? Nephrol Dial

Transplant, 2(23), 438-443.

Publications 211

376 Weert, E. van, Hoekstra-Weebers, J.E., May-de Groot, A.M., Korstjens, I., Ros, W.J.G. & Schans, C.P.

van der (2008). The development of an evidence-based physical self-management rehabilitation

programme for cancer survivors. Patient Education and Counseling, 71(2), 169-190.

377 Weikert, S., Boeing, H., Pischon, T., Weikert, C., Olsen, A., Tjonneland, A., Overvad, K., Becker, N.,

Linseisen, J., Trichopoulou, A., Mountokalakis, T., Trichopoulos, D., Sieri, S., Palli, D., Vineis, P.,

Panico, S., Peeters, P.H.M., Bueno-de-Mesquita, H.B., Verschuren, W.M., Ljungberg, B., Hallmans, G.,

Berglund, G., Gonzalez, C.A., Dorronsoro, M., Barricarte, A., Tormo, M.J., Allen, N., Roddam, A.,

Bingham, S, Khaw, K.T., Rinaldi, S., Ferrari, P., Norat, T. & Riboli, E. (2008). Blood pressure and risk

of renal cell carcinoma in the European prospective investigation into cancer and nutrition. American

Journal of Epidemiology, 167(4), 438-446.

378 Weinmayr, G., Forastiere, F., Weiland, S.K., Rzehak, P., Abramidze, T., Annesi-Maesano, I., Bjorksten,

B., Brunekreef, B., Buchele, G., Cookson, W.O., von Mutius, E., Pistelli, R. & Strachan, D.P. (2008).

International variation in prevalence of rhinitis and its relationship with sensitisation to perennial

and seasonal allergens. European Respiratory Journal, 32(5), 1250-1261.

379 Wermer, M.J.H., Koffijberg, H., Schaaf, I.C. van der, Algra, A., Rinkel, G.J.E. & ASTRA, Studygroup

(2008). Effectiveness and costs of screening for aneurysms every 5 years after subarachnoid

hemorrhage. Neurology, 70(22), 2053-2062.

380 Wermer, M.J.H., Schaaf, I.C. van der, Algra, A. & Rinkel, G.J.E. (2008). Response to letter by van der

Jagt et al (published in the January 2008 issue) (letter). Stroke, 39, e64-e64.

381 Wijk, I. van, Koudstaal, P.J., Kappelle, L.J., Gijn, J. van, Gorter, J.W., Algra, A & LiLAC, Study Group

(2008). Long-term occurrence of death and cardiovascular events in patients with transient ischaemic

attack or minor ischaemic stroke: comparison between arterial and cardiac source of the index event.

Journal of Neurology, Neurosurgery and Psychiatry, 79(8), 895-899.

382 Willers, S.M., Wijga, A.H., Brunekreef, B., Kerkhof, M., Gerritsen, J., Hoekstra, M.O., Jongste, J.C. de

& Smit, H.A. (2008). Maternal food consumption during pregnancy and the longitudinal

development of childhood asthma. American Journal of Respiratory and Critical Care Medicine,

178(2), 113-114.

383 Winters, S.M., Visser, H., Steerneman, A.H., Thomas, G., Bots, M.L. & Heijden, G.J.M.G. van der

(2008). Is there a need for dietary measures to further reduce LDL cholesterol in patients with type II

diabetes mellitus on statin therapy? Primary Care Diabetes, 2(1), 51-54.

384 Wit, N.J. de, Rubin, G. & Jones, R.H. (2008). Irritable bowel syndrome. In Clinical Evidence

Handbook. London: BMJ publishing group.

385 Wulp, I. van der, Baar, M.E. van & Schrijvers, A.J.P. (2008). Reliability and validy of the Manchester

Triage System in a general emergency department patient population in the Netherlands. Emergency

Medicine Journal, 25(7), 431-434.

386 Yli-Tuomi, T., Lanki, T., Hoek, G., Brunekreef, B. & Pekkanen, J. (2008). Determination of the sources

of indoor PM2.5 in Amsterdam and Helsinki. Environmental Science and Technology, 42(12), 4440-

4446.

387 Young, J., Sutter, A. de, Merenstein, D., Essen, G.A. van, Kaiser, L., Varonen, H., Williamson, I. &

Bucher, H.C. (2008). Antibiotics for adults with clinically diagnosed acute rhinosinusitis: a meta-

analysis of individual patient data. Lancet, 371(9616), 908-914.

388 Zaane, B. van, Zuithoff, N.P.A., Reitsma, J.B., Bax, L., Nierich, A.P. & Moons, K.G.M. (2008). Meta-

analysis of the diagnostic accuracy of transesophageal echocardiography for assessment of

atherosclerosis in the ascending aorta in patients undergoing cardiac surgery. Acta Anaesthesiologica

Scandinavica, 52, 1179-1187.

389 Zafarmand, M.H., Schouw, Y.T. van der, Grobbee, D.E., Leeuw, P.W. de & Bots, M.L. (2008). Alpha-

adducin Gly460Trp variant increases the risk of stroke in hypertensive Dutch women. Hypertension,

51(6), 1665-1670.


390 Zafarmand, M.H., Schouw, Y.T. van der, Grobbee, D.E., Leeuw, P.W. de & Bots, M.L. (2008).

Peroxisome proliferator-activated receptor gamma-2 P12A polymorphism and risk of acute

myocardial infarction, coronary heart disease and ischemic stroke: a case-cohort study and meta-

analyses. Vascular Health and Risk Management, 4(2), 427-436.

391 Zafarmand, M.H., Schouw, Y.T. van der, Grobbee, D.E., Leeuw, P.W. de & Bots, M.L. (2008). T64A

polymorphism in beta3-adrenergic receptor gene (ADRB3) and coronary heart disease: a case-cohort

study and meta-analysis. Journal of Internal Medicine, 263(1), 79-89.

392 Zafarmand, M.H., Nijdam, M.E., Franx, A., Grobbee, D.E. & Bots, M.L. (2008). The angiotensinogen

gene M235T polymorphism and development of preeclampsia: a meta-analysis and meta-regression

of observational studies. Journal of Hypertension, 26(9), 1726-1734.

393 Zafarmand, M.H., Schouw, Y.T. van der, Grobbee, D.E., Leeuw, P.W. de & Bots, M.L. (2008). The

M235T polymorphism in the AGT gene and CHD risk: evidence of a Hardy-Weinberg equilibrium

violation and publication bias in a meta-analysis. PLoS ONE [E], 3(6), e2533.

394 Zafarmand, M.H., Franx, A., Sabour, S., Schouw, Y.T. van der, Grobbee, D.E., Leeuw, P.W. de & Bots, M.L. (2008). The M235T variant of the angiotensinogen gene is related to development of self-

reported hypertension during pregnancy: Prospect-EPIC Cohort Study. Hypertension Research,

31(7), 1299-1305.

395 Zander, K. van der, Bots, M.L., Bak, A.A.A., Koning, M.M.G. & Leeuw, P.W. de (2008). Enzymatically

hydrolyzed lactotripeptides do not lower blood pressure in mildly hypertensive subjects. American

Journal of Clinical Nutrition, 88, 1697-1702.

396 Zhang, J., Regieli, J.J., Schipper, M., Entius, M.M., Liang, F., Koerselman, J., Ruven, H.J.T., Graaf, Y. van der, Grobbee, D.E. & Doevendans, P.A.F.M. (2008). Inflammatory gene haplotype-interaction

networks involved in coronary collateral formation. Human Heredity, 66(4), 252-264.

397 Zijlmans, G.J.M., Buskens, E., Hersevoort, M., Huiskamp, G.J.M., Huffelen, A.C. van & Leijten, F.S.S.

(2008). Should we reconsider epilepsy surgery? The motivation of patients once rejected. Seizure: the

Journal of the British Epilepsy Association, 17(4), 374-377.

398 Zuidgeest, M.G.P., Smit, H.A., Bracke, M., Wijga, A.H., Brunekreef, B., Hoekstra, M.O., Gerritsen, J.,

Kerkhof, M., Jongste, J.C. de & Leufkens, H.G.M. (2008). Persistence of asthma medication use in

preschool children. Respiratory Medicine, 102(10), 1446-1451.

399 Zuidgeest, M.G.P., Dijk, L. van, Smit, H.A., Wouden, J.C. van der, Brunekreef, B., Leufkens, H.G.M. &

Bracke, M. (2008). Prescription of respiratory medication without an asthma diagnosis in children: a

population based study. BMC Health Services Research, 8, 16.

400 Zuilen, A.D. van, Wetzels, J.F., Bots, M.L. & Blankestijn, P.J. (2008). MASTERPLAN: study of the role

of nurse practitioners in a multifactoral intervention to reduce cardiovascular risk in chronic kidney

disease patients. Journal of Nephrology, 21(3), 261-267.

Professional Publications

1 Algra, A., Schryver, E.L.L.M. de & Halkes, P.H.A. (2008). [Thromboprophylaxis for cerebrovascular

disorders: acetylsalicyclic acid remains the cornerstone.]. Nederlands Tijdschrift voor Geneeskunde,

152(20), 1179-1179.

2 Akkerman, A.E., Verheij, Th.J.M., Grobbee, D.E. & Hak, E. (2008). Interactieve medische informatie

van het Huisartsen Netwerk Utrecht en de Almere Zorggroep. Huisarts en Wetenschap, 51(2), 90-95.

3 Besselink, M.G.H., Santvoort, H.C. van, Buskens, E., Akkermans, L.M.A. & Gooszen, H.G. (2008).

Probiotic prophylaxis in predicted severe acute pancreatitis - Authors’ reply. Lancet, 372(9633), 114-

114.

Publications 213

4 Besselink, M.G.H., Santvoort, H.C. van, Buskens, E., Boermeester, M.A., Goor, H. van, Timmerman,

H., Nieuwenhuijs, V.B., Bollen, T.L., Ramshorst, B. van, Witteman, B.J., Rosman, C., Ploeg, R.J., Brink,

M.A., Schaapherder, A.F., Dejong, C.H. van, Wahab, P.J., Laarhoven, C.J.H.M. van, Harst, E. van der,

Eijck, C.H.J. van, Cuesta, M.A., Akkermans, L.M.A. & Gooszen, H.G. (2008). Probioticaprofylaxe bij

voorspeld ernstige acute pancreatitis: een gerandomiseerde, dubbelblinde, placebogecontroleerde

trial. Nederlands Tijdschrift voor Geneeskunde, 152(12), 685-696.

5 Beus, M.F. de & Mosterd, A. (2008). [Establishment of a national registry for sudden cardiac arrest in

athletes.]. Nederlands Tijdschrift voor Geneeskunde, 152(37), 2037-2038.

6 Bonten, M.J.M. (2008). [Medical microbiology laboratories in Dutch hospitals: essential for safe

patient care. Nederlands Tijdschrift voor Geneeskunde, 152, 2650-2652.

7 Boom, F., Meijel, B.K.G. van, Wesselink, W. & Stringer, B. (2008). Gedeelde smart: het betrekken van

naasten bij de verpleegkundige zorg voor de suïcidale patiënt. Psychopraxis, 10(2), 70-74.

8 Bruggen, J.A.R. van, Gorter, K.J., Stolk, R.P. & Rutten, G.E.H.M. (2008). Alleen door delegeren wordt

de diabeteszorg niet beter. Tijdschrift voor praktijkondersteuning, 1, 187-190.

9 Brunekreef, B. (2008). De lange adem. VVM Milieu, 2, 17-21.

10 Cate, Th.J. ten, Horsman, M.A., Luijk, S.J. van & Scheele, F (2008). Richtlijnen voor het onderwijs in

de medische vervolgopleidingen: waarom en hoe? Tijdschrift voor Medisch Onderwijs, 27(6), 272-

278.

11 Derde, L.P.G. & Hoepelman, I.M. (2008). Wat is de (klinische) betekenis van ondertemperatuur bij

infectieuze aandoeningen en wat is de ondergrens? Longartsen Vademecum, 11(16).



Priori, S.G. & Swedberg, K (2008). [ESC Guidelines for the Diagnosis And Treatment of Acute And

Chronic Heart Failure 2008] Versión premilinar en fase de revisión. Revista Espanola de Cardiologia,

61(12), 1329.e1-1329.e70.

13 Essen, G.A. van & Sutter, A. de (2008). Hebben volwassenen met acute rhinosinusitis baat bij

behandeling met antibiotica? Huisarts en Wetenschap, 51, 270-274.

14 Galan, B.E. de, Tack, C.J. & Grobbee, D.E. (2008). Iedereen met diabetes heeft recht op

bloeddrukverlaging. Huisarts en Wetenschap, 51(12), 596-597.

15 Geldrop, W.J. van, Numans, M.E., Berg, H.F., Putten, A.M. van, Scheele, M.E. & Bouma, M. (2008).

NHG Standaard virushepatitis en andere leveraandoeningen. Huisarts en Wetenschap, 50(12), 666-

681.

16 Graaf, Y. van der (2008). Echographic screening of the abdominal aorta in older men is not useful.

Nederlands Tijdschrift voor Geneeskunde, 152(13), 751.

17 Hak, E., Opstelten, W., Looijmans-van den Akker, I. & Knottnerus, J.A. (2008). [Influenza

vaccination in the elderly: effectiveness not in doubt] Griepvaccinatie bij ouderen: geen twijfel aan de

effectiviteit. Nederlands Tijdschrift voor Geneeskunde, 152(19), 1081-1083.

18 Halm-Walters, M.M. van, Bijl, J.J. van der & Swieten-Duijfjes, B. van (2008). Van revalidant tot

manager: een literatuurstudie naar zelfmanagement bij personen met een dwarslaesie. Verpleegkunde

: Nederlands-Vlaams wetenschappelijk tijdschrift voor verpleegkundigen, 23(2), 108-117.

19 Hamelink-Baksteen, K., Houben, F.C., Bun, C.J. & Wit, N.J. de (2008). Preventie en reductie van

overgewicht bij kinderen in het basisonderwijs: de effectiviteit van een lokaal multidisciplinair

interventieprogramma. Huisarts en Wetenschap, 13, 651-657.

20 Hoogerduijn, J.G., Weldam, S.W.M. & Schuurmans, M.J. (2008). Ontwikkeling van een senior

gerichte anamnese. TVZ : Tijdschrift voor Verpleegkundigen, 5, 46-49.

21 Isterdael, C.E.D. van, Stilma, J.S., Bezemer, P.D. & Tijmes, N.T. (2008). Determinanten van het al dan

niet behandelen van refractieafwijkingen en cataract bij mensen met een verstandelijke beperking.

Nederlands Tijdschrift voor Geneeskunde, 152(18), 1048-1051.


22 Jaarsma, T., Wal, M.H. van der, Lesman-Leegte, I, Luttik, M.L., Hogenhuis, J., Veeger, N.J., Sanderman,

R., Hoes, A.W., Gilst, W.H. Van, Lok, DJ, Dunselman, P.H.J.M., Tijssen, J.G., Hillege, H.L. &

Veldhuisen, D.J. van (2008). [Value of basic or intensive management of patients with heart failure

confirmed in a randomised controlled clinical trial.]. Nederlands Tijdschrift voor Geneeskunde, 52,

2016-2021.

23 Kiemeney, L., Lemmers, F.A., Verhoeven, R.H., Aben, K.K., Honing, C., Nooijer, J. de, Peeters, P.H.M., Visser, O. & Vlems, F.A. (2008). [The risk of cancer in the Netherlands]. Nederlands Tijdschrift voor

Geneeskunde, 152(41), 2233-2241.

24 Koeman, M., Ven, A.J. van der, Hak, E., Joore, J.C.A., Kaasjager, H.A.H., Smet, A.M.G.A. de, Ramsay,

G., Dormans, T.P., Aarts, L.P., Bel, E.E. de, Hustinx, W.N.M., Tweel, I. van der, Hoepelman, I.M. &

Bonten, M.J.M. (2008). Less ventilator-associated pneumonia after oral decontamination with

chlorhexidine; a randomised trial. Nederlands Tijdschrift voor Geneeskunde, 152(13), 752-759.

25 Korstjens, I., May, A.M. & Weert, E. van (2008). Revalidatie voor overlevende van kanker. Tijdschrift

Kanker, 32(6), 14-17.

26 Korstjens, I., May, A.M. & Weert, E. van (2008). Revalidatie voor overlevende van kanker: Positieve

(langetermijn) effecten op kwaliteit van leven. Bulletin / Nederlandse Vereniging voor Psychosociale

Oncologie, 16(3), 10-11.

27 Leusink, P., Boer, L.J. de, Vliet Vlieland, C.W., Rambharose, V.R., Sprengers, A.M., Mogendorf, S.W. &

Rijn-Kortenhoef, N.M.M. van (2008). NHG-standaard Erectiele Dysfunctie. Huisarts en Wetenschap,

51(8), 381-394.

28 Looijmans-van den Akker, I., Opstelten, W., Hak, E., Groeneveld, K.M & Knottnerus, J.A. (2008).

Griepvaccinatie: Advies Gezondheidsraad over griepvaccinatie. Huisarts en Wetenschap, 51(4), 169-

173.

29 May-de Groot, A.M. & Ros, W.J.G. (2008). Het Oncorev onderzoek. Oedeminus, 2, 8-11.

30 Meijel, B.K.G. van (2008). Naar verdere professionalisering van de psychiatrisch verpleegkundige

zorg. Verpleegkunde : Nederlands-Vlaams wetenschappelijk tijdschrift voor verpleegkundigen, 23(2),

139-142.

31 Meijel, B.K.G. van, Hage, S., Fluttert, F.A.J. & Berden, G. (2008). Preventie van agressie bij jeugdigen.

TVZ : Tijdschrift voor Verpleegkundigen, 10, 44-49.

32 Meijel, B.K.G. van (2008). Verpleegkundige zorg bij bipolaire stoornissen. TVZ : Tijdschrift voor

Verpleegkundigen, 118(4), 49-49.

33 Menko, F.H., Hoogebrugge, N., Barneveld, T.A. van, Bleiker, E., Zeelenberg, M., Gille, J.J.P., Jing,

R.H.A. de, Young, I.M.A., Kleibeuker, J.H., Ligtenberg, M.J., Morreau, J., Mourits, M.J.E., Nagengast,

F.M., Sijmons, R.H., Slors, J.F.M., Spijker, H.G. van, Steeg, M. van der, Taminiau, J.A.J.M., Voskuil,

D.W. & Wit, N.J. de (2008). Landelijke richtlijn erfelijke darmkanker.

34 Molenaar, E.A., Numans, M.E., Ameijden, E.J.C. van & Grobbee, D.E. (2008). [Considerable

comorbidity in overweight adults: results from the Utrecht Health Project]. Nederlands Tijdschrift

voor Geneeskunde, 152(45), 2457-2463.

35 Mulder, C.J., Beer, J. de, Beld, M., Blomberg, B.M. von, Groot, A.C. de, Hopman, G.D., Klinken, F. van,

Kolkman, J.J., Loffeld, R.L., Mearin Manrique, M.L., Meyer, J.W., Tonino, M.A., Numans, M.E., Oudkerk Pool, M., Scheenstra, R., Stoof, J.C. & Wahab, P.J. (2008). CBO-richtlijn coeliakie en

dermatitis herpetiformis. Utrecht: CBO.

36 Oosterheert, J.J., Bonten, M.J.M., Schneider, M.M.E., Buskens, E., Lammers, J.W.J., Hustinx, W.N.M.,

Kramer, M.H.H., Prins, J.M., Slee, Ph.Th.J., Kaasjager, K. & Hoepelman, I.M. (2008). [An early switch

from intravenous to oral antibiotics is equally effective as the standard intravenous therapy in severe

community acquired pneumonia]. Nederlands Tijdschrift voor Geneeskunde, 152(5), 269-274.

37 Opstelten, W., Essen, G.A. van, Laan, JR van der & Geijer, R.M.M. (2008). Antivirale middelen bij

griep: zelden geindiceerd. Huisarts en Wetenschap, 51, 167-168.

38 Opstelten, W., Essen, G.A. van, Baillieux, M.J.P. & Goudswaard, A.N. (2008). Nog weinig huisartsen

ingeënt tegen de griep. Huisarts en Wetenschap, 51, 610-613.

Publications 215

39 Opstelten, W., Essen, G.A. van, Laan, JR van der, Geijer, R.M.M. & Goudswaard, A.N. (2008).

[Summary of the practice guideline ‘Influenza and influenza vaccination’ (first revision) from the

Dutch College of General Practitioners] Samenvatting van de standaard ‘Influenza en

influenzavaccinatie’ (eerste herziening) van het Nederlands Huisartsen Genootschap. Nederlands

Tijdschrift voor Geneeskunde, 152(39), 2116-2119.

40 Rossum, T.G.J. van, Melker, H.E. de, Houweling, H., Voordouw, A.C.G., Meijer, C.J.L.M., Helmerhorst,

T.J.M., Kretzschmar, M.E.E., Berkhof, J. & Noordaa, J. van der (2008). [Vaccines against human

papillomavirus (HPV); between registration and implementation]. Nederlands Tijdschrift voor

Geneeskunde, 152(17), 987-992.

41 Rutten, G.E.H.M. (2008). [Care of patients with type 2 diabetes mellitus in primary care]. Nederlands

Tijdschrift voor Geneeskunde, 152(44), 2389-2394.

42 Rutten, G.E.H.M. (2008). Preventie van harten vaatziekten bij diabetes mellitus type 2. Modern

Medicine (Nederlandse ed.), 32(9A), 4-8.

43 Rutten, F.H., Cramer, M.J.M., Lammers, J.W.J., Grobbee, D.E. & Hoes, A.W. (2008). NT-proBNP bij

de diagnostiek van hartfalen in de huisartspraktijk bij oudere patiënten met COPD. Hart Bulletin, 39,

112-117.

44 Rutten, F.H. (2008). Patiënten met COPD hebben vaak ook hartfalen. Cordiaal, 1, 19-21.

45 Sachs, A.P.E. (2008). De man die ‘s morgens plotseling met dubbele tong sprak. Nederlands

Tijdschrift voor Allergie, 3, 14-17.

46 Sachs, A.P.E. (2008). Zijn er praktische richtlijnen voortgekomen uit de studies met betrekking tot

preventie van allergische aandoeningen waaronder astma en astma bij kinderen? Nederlands

Tijdschrift voor Allergie, 3, 537-551.

47 Schayck, C.P. van & Sachs, A.P.E. (2008). Onderdiagnostiek van astma en rhinitis in de

huisartspraktijk. Nederlands Tijdschrift voor Allergie, 2, 27-31.

48 Scheltens, T., Grobbee, D.E., Kok, L., Verschuren, W.M.M., Bots, M.L., Numans, M.E. & Hoes, A.W. (2008). Van de NHG-standaard Cholesterol naar de NHG-standaard Cardiovasculair

risicomanagement: en nu? Huisarts en Wetenschap, 51(9), 420-425.

49 Schryver, E.L.L.M. de, Halkes, P.H.A. & Algra, A.. (2008). [No role for oral anticoagulants (target INR;

2.0-3.0) after transient ischaemic attack or cerebral infarction of arterial origin; the European/

Australasian stroke prevention in reversible ischaemia trial (ESPRIT).]. Nederlands Tijdschrift voor

Geneeskunde, 152(8), 445-453.

50 Starreveld, J.S., Zwart, S., Boukes, F.S., Wiersma, T. & Goudswaard, A.N. (2008). [Summary of the

practice guideline ‘Sore throat’ (second revision) from the Dutch College of General Practitioners]

Samenvatting van de standaard ‘Acute keelpijn’ (tweede herziening) van het Nederlands Huisartsen

Genootschap. Nederlands Tijdschrift voor Geneeskunde, 152(8), 431-435.

51 Thiel, G.J.M.W. van (2008). Therapeutische misvatting in klinisch onderzoek. METCforum, 12(1),

3-6.

52 Uijen, J.H.J.M., Duijn, H.J. van, Kuyvenhoven, M.M., Schellevis, F. & Wouden, H. van der (2008).

Kinderen met hoesten, keelpijn en oorpijn. Huisarts en Wetenschap, 51(13), 663-668.

53 Vaartjes, C.H. & Bots, M.L. (2008). Hartfalen: Feiten en cijfers. Hart Bulletin, 39(5), 131-134.

54 Vaartjes, C.H., Dis, SJ van, Peters, R.J.G. & Bots, M.L. (2008). Ingrepen bij hartritmestoornissen,

hartoperaties en percutane coronaire interventies: Cijfers en feiten. Hart Bulletin, 39(1), 21-23.

55 Vaartjes, C.H. & Bots, M.L. (2008). Perifeer arterieel vaatlijden: Feiten en cijfers. Hart Bulletin, 39(6),

161-167.

56 Venekamp, R.P., Melker, R.A. de, Kuyvenhoven, M.M. & Damoiseaux, R.A.M.J. (2008). Vijftig jaar

bovensteluchtweginfecties vóór en dóór huisartsen. Huisarts en Wetenschap, 51(5), 247-250.

57 Verheij, Th.J.M. (2008). De huisarts staat niet met lege handen. Huisarts en Wetenschap, 51(4), 166.

58 Visseren, F.L.J. & Graaf, Y. van der (2008). Twijfel aan het bestaan en de klinische relevantie van

‘nieuwe’ risicodeterminanten voor harten vaatziekten is onterecht. Nederlands Tijdschrift voor

Geneeskunde, 152(45), 2480-2481.


59 Vlimmeren, L.A. van, Helders, P.J.M., Graaf, Y. van der, Boere-Boonekamp, M.M., L’Hoir, M.P. &

Engelbert, R.H.H. (2008). State of the arts. Zuigelingenasymmetrie; voorkeurshouding en

deformatieve plagiocefalie. Nederlands Tijdschrift voor Fysiotherapie, 118(4), 95-100.

60 Wassenberg, M.W.M., Bonten, M.J.M., Troelstra, A., Kluytmans, J.A.J.W. & Hopmans, T.E.M. (2008).

[Meticillineresistente Staphylococcus aureus afkomstig uit de veestapel in Nederlandse ziekenhuizen:

risicopatiënten alleen controleren bij eventuele ziekenhuisopname]. Nederlands Tijdschrift voor

Geneeskunde, 152, 2681-2688.

61 Wertheim, H.F.L., Bonten, M.J.M., Kluytmans, J.A.J.W., Vos, M.C., Broek, P.J. van den,

Vandenbroucke-Grauls, C.M.J.E., Troelstra, A. & Ammerlaan, H.S.M. (2008). [Optimaliseren van het

antibioticabeleid in Nederland. XII. SWAB-richtlijn voor de behandeling van MRSA-dragerschap].

Nederlands Tijdschrift voor Geneeskunde, 152, 2667-2671.

62 Wit, N.J. de (2008). [Rol huisarts bij opsporing colon kanker]. Patient Care. Het tijdschrift voor de

huisarts, 11(35), 29-34.

Books and Book Chapters

1 Algra, A. (2008). Randomized trials. In Hoes, A.W. Grobbee, D.E. (Ed.), Clinical Epidemiology:

principles, methods, and applications for clinical research (pp. 270-287). Sudbury, MA, U.S.A.: Jones

and Bartlett Publishers.

2 Agyemang, C., Vaartjes, C.H., Bots, M.L., Valkengoed, I.G., Munter, J.S. de, Bruin, A. de, Berger-van

Sijl, M., Reitsma, J.B. & Stronks, K. (2008). Verschillen tussen etnische bevolkingsgroepen in de kans

op overlijden na een eerste zieknhuisopname vanwege harten vaatziekten. In C.H. Vaartjes, R.J.G.

Peters, S.J. van Dis & M.L. Bots (Eds.), Hart- en vaatziekten in Nederland, 2008. Cijfers over ziekte en

sterfte: Nederlandse Hartstichting (pp. 23-37). Den Haag: Nederlandse Hartstichting.

3 Bosch, J.L.H.R., Lock, M.T.W.T. & Pieters, H.M. (2008). Urologie. In J.J.E. van Everdingen & J.H.

Glerum (Eds.), Diagnose en Therapie. Houten: Bohn Stafleu en Van Loghum.

4 Bruin, M. de & Otter, J. den (2008). Reumatoïde artritis. In A Donker, J. van der Heide, I.M.A.A.

Keusters & S.M. van Os (Eds.), Dieet behandelingsrichtlijnen. Maarssen: Elzevier Gezondheidszord.

5 Brussel, M. van, Takken, T., Uiterwaal, C.S.P.M., Pruijs, J.E.H., Net, J. van der, Helders, P.J.M. &

Engelbert, R.H.H. (2008). Physical training in children with osteogenesis imperfecta. In T Jurimae, N

Armstrong & J Jurimae (Eds.), Children and Exercise XXIV (pp. 185-189). London and New York:

Routlegde, Taylor & Francis Group.

6 Delden, J.J.M. van (2008). Levenskunst als basis voor de zorg voor ouderen. In K. Boele-Woelki (Ed.),

Actuele ontwikkelingen in het familierecht (pp. 45-61). Nijmegen: Ars Aequi Libri.

7 Delden, J.J.M. van (2008). Convergent trends in modern medical ethics: Medicine-based ethics and

human rights. In Ronald.M. Green, Aine Donovan & Steven.A. Jauss (Eds.), Global bioethics. Issues of

conscience for the twenty-first century (Issues in biomedical ethics) (pp. 77-86). Oxford: Oxford

University Press.

8 Delden, J.J.M. van & Battin, M.P. (2008). Physician-assisted death: not just for rich countries. In

Ronald.M. Green, Aine Donovan & Steven.A. Jauss (Eds.), Global bioethics (Issues in biomedical

ethics) (pp. 243-261). Oxford: Oxford University Press.

9 Deutsch, A., Bravo de la Parra, R., Boer, R.J. de, Diekmann, O., Jagers, P., Kisdi, E., Kretzschmar, M.E.E., Lansky, P. & Metz, H. (Eds.). (2008). Mathematical Modeling of Biological Systems, Volume

II. Boston: Birkhauser.

Publications 217

10 Festen, H.P.M., Wit, N.J. de & Brouwers, J.R.B.J. (2007). Gastroenterologie. In Diagnose and Therapie

Jaarboek 2008. Houten: Bohn Stafleu van Loghum.

11 Gast, G.C.M. & Schouw, Y.T. van der (2008). Menopauze en harten vaatziekten. In C.H. Vaartjes,

R.J.G. Peters, S.J. van Dis & M.L. Bots (Eds.), Hart- en vaatziekten in Nederland, 2008. Cijfers over

ziekte en sterfte (pp. 113-126). Den Haag: Nederlandse Hartstichting.

12 Gianotten, W.L., Franssen, J.M., Boer, L.J. de, Ohlrichs, Y.S.A. & Son-Schoones, N. van (2008).

Aspecten van diversiteit. In W.L. Gianotten, M.J. Meihuizen-de Regt & N van Son-Schoones (Eds.),

Seksualiteit bij ziekte en lichamelijke beperking (pp. -H 1.6). van Gorcum.

13 Grobbee, D.E. & Hoes, A.W. (2008). Clinical epidemiology. Principles, Methods, and Applications for

Clinical Research. Boston: Jones and Bartlett Publishers, LLC.

14 Hoekstra, M.O. & Sachs, A.P.E. (Eds.). (2008). Het Kinderallergie formularium, een praktische

leidraad. Houten: Bohn, Stafleu, van Loghum Healthcare Communications.

15 Hoes, A.W. (2008). De dokter, de apotheker en het College. In D.S. Slijkerman, J.M. van Ree, R.T.W.

Meijer & E.M.A. Breeveld (Eds.), Openheid van zaken. De werkzaamheden van het College ter

Beoordeling van Geneesmiddelen (pp. 97-106). Den Haag: SDU uitgevers.

16 Kretzschmar, M.E.E. (2008). Infectious Disease Modeling. In Kris Heggenhougen and Quah (Eds),

International Encyclopedia of Public Health. San Diego: Academic Press.

17 Loffeld, R. & Numans, M.E. (Eds.). (2008). Handboek Refluxziekte. Utrecht: Academic Publishers.

18 Numans, M.E., Schers, H. & Soons, P.H.G.M. (Eds.). (2008). Leven met Diabetes mellitus type 2 (serie

‘Leven met’). Houten/Antwerpen: Bohn Stafleu van Loghum.

19 Roos, N.M. de (2008). Evidence-based Diëtetiek: principes en werkwijze. In M Former-Boon & J.J.

van Duinen (Eds.), Evidence based dietetiek (pp. 13-21). Houten: Bohn Stafleu van Loghum.

20 Roos, N.M. de (2008). Evidence-based Diëtetiek: stap voor stap. In M. Former-Boon & J.J. van Duinen

(Eds.), Evidence based Diëtetiek (pp. 22-42). Houten: Bohn Stafleu van Loghum.

21 Roos, N.M. de (2008). Implementatie van evidence-based dietetiek in de praktijk. In M. Former-Boon

& J.J. van Duinen (Eds.), Evidence based Diëtetiek (pp. 106-115). Houten: Bohn Stafleu van Loghum.

22 Schlösser, F.J.V., Vaartjes, C.H., Heijden, G.J.M.G. van der, Moll, F.L., Verhagen, H.J.M., Muhs, B.E.,

Kardaun, J.W., Bruin, A. de, Reitsma, J.B., Graaf, Y. van der & Bots, M.L. (2008). De kans op

overlijden na een eerste ziekenhuisopname vanwege een geruptureerd aneurysma van de abdominale

aorta. In C.H. Vaartjes, R.J.G. Peters, S.J. van Dis & M.L. Bots (Eds.), Hart- en vaatziekten in

Nederland, 2008. Cijfers over ziekte en sterfte: Nederlandse Hartstichting (pp. 85-97). Den Haag:

Nederlandse Hartstichting.

23 Schlösser, F.J.V., Vaartjes, C.H., Heijden, G.J.M.G. van der, Moll, F.L., Verhagen, H.J.M., Muhs, B.E.,

Kardaun, J.W., Bruin, A. de, Reitsma, J.B., Graaf, Y. van der & Bots, M.L. (2008). De kans op

overlijden na een electieve behandeling van een abdominaal aorta aneurysma. In C.H. Vaartjes, R.J.G.

Peters, S.J. van Dis & M.L. Bots (Eds.), Hart- en vaatziekten in Nederland, 2008. Cijfers over ziekte en

sterfte: Nederlandse Hartstichting (pp. 69-80). Den Haag: Nederlandse Hartstichting.

24 Thiel, G.J.M.W. van (2008). Laat Ashley niet meer groeien. In I. de Beaufort, M. Hilhorst, S.

Vandamme & S. van de Vathorst (Eds.), De Kwestie. Praktijkboek ethiek voor de gezondheidszorg (pp.

91-97). Den Haag: Lemma.

25 Vaartjes, C.H., Peters, R.J.G., Dis, SJ van & Bots, M.L. (2008). Hart- en vaatziekten in Nederland,

2008. Cijfers over ziekte en sterfte: Nederlandse Hartstichting. Den Haag: Nederlandse Hartstichting.

26 Vaartjes, C.H., Dis, SJ van, Peters, R.J.G., Visseren, F.L.J. & Bots, M.L. (2008). Hart- en vaatziekten in

Nederland naar geslacht. In C.H. Vaartjes, R.J.G. Peters, S.J. van Dis & M.L. Bots (Eds.), Hart- en

vaatziekten in Nederland, 2008. Cijfers over ziekte en sterfte: Nederlandse Hartstichting, Den Haag

(pp. 9-22). Den Haag: Nederlandse Hartstichting.

27 Vaartjes, C.H., Reitsma, J.B., Bruin, A. de & Bots, M.L. (2008). Verschillen tussen mannen en vrouwen

in sterftekans na een eerste ziekenhuisopname vanwege hartfalen. In C.H. Vaartjes, R.J.G. Peters, S.J.

van Dis & M.L. Bots (Eds.), Hart- en vaatziekten in Nederland, 2008. Cijfers over ziekte en sterfte:

Nederlandse Hartstichting (pp. 55-66). Den Haag: Nederlandse Hartstichting.


28 Verheugt, C.L., Uiterwaal, C.S.P.M., Velde, E.T. van der, Meijboom, F.J., Pieper, P.G., Vliegen, H.W.,

Dijk, A.P.J. van, Bouma, B.J, Grobbee, D.E. & Mulder, B.J.M. (2008). Verschillen in klinische uitkomst

tussen mannen en vrouwen met aangeboren hartafwijkingen. In C.H. Vaartjes, R.J.G. Peters, S.J. van

Dis & M.L. Bots (Eds.), Hart- en vaatziekten in Nederland, 2008. Cijfers over ziekte en sterfte (pp. 41-

53). Den Haag: Nederlandse Hartstichting.

29 Wit, N.J. de, Rubin, G. & Jones, R.H. (2008). Irritable bowel syndrome. In Clinical Evidence

Handbook. London: BMJ publishing group.

Publications 219


Inleiding

Het Julius Centrum voor Gezondheidswetenschappen en Eerstelijns

Geneeskunde heeft een eenvoudige strategie. Doe alles wat noodzakelijk

is om uitmuntend onderzoek en onderwijs in de gezondheidsweten-

schappen te realiseren. Ondanks het feit dat onze successen op het

gebied van onderzoek lijken te overheersen, zijn we ervan overtuigd dat

de basis van onze prestaties in de wetenschap en gezondheidszorg wordt

gevormd door hoogwaardig onderwijs.

In 2008 vonden verschillende veranderingen plaats binnen de organisa-

tie. De lijnorganisatie werd versterkt en de coördinatoren van de vijf

onderzoekslijnen kregen meer verantwoordelijkheden. Daarnaast heb-

ben het management van het Julius Centrum en de Raad van Bestuur

van het UMC Utrecht na zorgvuldige overweging besloten om de

Clinical Trial activiteiten onder te brengen in een aparte onafhankelijke

academische onderzoeksorganisatie: Julius Clinical Research B.V.

Verder werd in 2008 het vroegere universitaire Centrum voor

Biostatistiek opgenomen in het Julius Centrum en vertrok de afdeling

Verplegingswetenschap.

In 2008 werden op het gebied van onderwijs en onderzoek heel wat suc-

cessen geboekt. Een record aantal studenten studeerde af bij de vakoplei-

ding Huisartsgeneeskunde en het MSc programma Epidemiologie. Ook

met het aantal afgeronde proefschriften vestigde het Julius Centrum een

nieuw record. Maar liefst 39 kandidaten verdedigden hun proefschrift

met een staflid van het Julius Centrum als (co-)promotor. Rick Grobbee

werd voor de vierde keer ‘PhD Supervisor of the Year’ met een totaal van

meer dan 100 promovendi die hij succesvol hun proefschrift liet verde-

digen. Daarnaast waren de stafleden van het Julius Centrum betrokken


bij 400 internationale wetenschappelijke publicaties, waarvan 10 in de

vooraanstaande tijdschriften The Lancet, New England Journal of

Medicine en JAMA. De wetenschappelijke positie van het Julius

Centrum werd verder benadrukt door de toekenning van twee belangrij-

ke prijzen, de Heineken en de Catharijne prijs, aan respectievelijk de

professoren Bert Brunekreef en Rick Grobbee.


Organisatie

Vanaf het ontstaan in 1996 is het Julius Centrum gegroeid zowel qua

grootte als qua werkgebied. Het Centrum werd aanvankelijk opgericht

door het samenvoegen van de afdelingen Epidemiologie en Public

Health en de verpleegafdeling van Klinische Epidemiologie. In 1999 wer-

den de afdelingen Huisartsgeneeskunde en Patiënt-gericht Onderzoek

toegevoegd. Het huidige Julius Center voor Gezondheidswetenschappen

en Eerstelijns Geneeskunde ontstond door de toevoeging van de afdelin-

gen Verplegingswetenschap en Voedingswetenschappen in 2002.

Meerdere ontwikkelingen hebben plaatsgevonden binnen de organisatie

in 2008. Biostatistiek werd toegevoegd aan het Centrum om opleiding

en onderzoek op dit gebied te versterken. Door reorganisatie werd de

discipline Verplegingswetenschap opgeheven binnen het Julius Centrum.

Daarnaast werd een aantal activiteiten van de Clinical Trial Unit onder-

gebracht bij een onafhankelijke organisatie, Julius Clinical Research, die

zich bezighoudt met de uitvoering van grootschalige trials.


Onderzoek

Het onderzoek van het Julius Centrum valt binnen het UMC program-

ma Epidemiologie. Binnen dit programma levert het Julius Centrum de

voornaamste bijdrage aan het totale onderzoek van het UMC Utrecht.

Daarnaast draagt het Julius Centrum bij aan de vier ziekte-gerelateerde

onderzoeksgebieden van het UMC Utrecht: harten vaatziekten, infec-

tieziekten en immunologie, kanker en geestelijke gezondheid. Tot slot is

het Julius Centrum ook betrokken bij de twee andere methodologische

onderzoeksthema’s van het UMC Utrecht, te weten beeldwetenschappen

en genomics.

Onderzoek binnen het Julius Centrum is georganiseerd volgens een

matrixstructuur zoals die van het UMC Utrecht. Langs de horizontale as

de wetenschappelijke disciplines; Klinische Epidemiologie, Huisarts-

geneeskunde, Public Health, Biostatistiek, MTA, Medische Ethiek,

Voedingswetenschappen en Verplegingswetenschap. Langs de verticale as

staan de hierboven genoemde vier ziekte-gerelateerde onderzoekslijnen

met daaraan toegevoegd een methodologische onderzoekslijn.

Het Julius Centrum heeft formele banden met de volgende afdelingen/

groepen binnen de Universiteit Utrecht: het interfacultaire Institute for

Risk Assessment Sciences (IRAS), Environmental and Occupational

Epidemiology, farmaco-epidemiologie en veterinaire epidemiologie.

Het Julius Centrum geeft methodologisch advies en ondersteuning voor

klinisch onderzoek aan vrijwel alle afdelingen van het UMC. Stafleden

worden ingezet als adviseurs voor onderzoeksmethoden zowel binnen

als buiten het UMC Utrecht.


Onderzoekslijnen

Hart- en vaatziekten

Deze onderzoekslijn is de meest omvangrijke van de vier onderzoekslij-

nen binnen het Julius Centrum. Het onderzoek maakt gebruik van epi-

demiologische onderzoeksmethoden, zoals multi-centered randomized

controlled trials om de effecten van preventief en therapeutisch ingrij-

pen te onderzoeken, en cohort, case-control en cross-sectional onder-

zoek. De nadruk ligt op oorzaken, diagnose, prognose en behandeling

van harten vaatziekten.

Het onderzoek naar harten vaatziekten is geconcentreerd rond een

aantal thema’s.

1 Factoren vroeg in het leven die de kans op harten vaatziekten

vergroten

2 Endocrinologische aspecten van harten vaatziekten

3 Internationale trials

4 Diagnose en prognose van harten vaatziekten in de eerstelijn

5 Vasculaire complicaties bij type 2 diabetes mellitus in de eerstelijns

zorg

6 Voorspellen van recidief harten vaatziekten

7 Diagnose en prognose van atherosclerose

8 Preventie van complicaties na een eerste vasculaire cerebrale ziekte

9 Epidemiology van hemofilie

Belangrijk onderzoek wordt verricht op het raakvlak met huisartsge-

neeskunde, aangezien de huisarts de portier is van de Nederlandse

gezondheidszorg. Daarom is diagnose in de eerstelijns zorg een belang-

rijk onderzoeksonderwerp zowel in het algemeen binnen het Julius

Centrum als bij deze onderzoekslijn. In dit kader werd in de AMUSE

studie gekeken naar het effect van een diagnostische voorspellingsregel


in de eerstelijns zorg bij het vaststellen van diepe veneuze trombose in

het been. Deze studie werd in 2008 succesvol afgesloten. In 2008 werd

ook gestart met de multi-center studie FAME, waarbij gekeken wordt

naar diagnose in de eerstelijns zorg van acuut coronair syndroom.

Het Julius Centrum is sinds 1996 betrokken bij het cohort onderzoek

SMART betreffende patiënten met een hoog risico op cardiovasculaire

ziekte (CVD). In 2008 werden vijf proefschriften die voortkwamen uit

dit onderzoek succesvol verdedigd en kreeg het onderzoek een vervolg in

SMART-2. Daarnaast werd in 2008 een grootschalig onderzoek gestart

dat erop gericht is harten vaatziekten al op jonge leeftijd te diagnostice-

ren en te voorkomen.

Infectieziekten

Het onderzoek naar infectieziekten is geconcentreerd rond vier onder-

werpen:

1 Voorkomen, diagnose en prognose van infecties van de

ademhalingswegen

2 Doeltreffendheid van vaccinatiestrategieën

3 Mathematische modellen van infectieziekten

4 Effecten van ziekenhuisinfecties en de overdracht van antibiotica-

resistente bacteriën op patiënten

Kanker

Het kankeronderzoek binnen het Julius Centrum richt zich op de oor-

zaak, vroege diagnose en prognose van hormoon-gerelateerde kanker,

met name bij vrouwen. Het onderzoek naar de oorzaken richt zich met

name op de interactie tussen genen, hormonen en levensstijl.


Er is een nauwe samenwerking met de afdeling Epidemiology and Public

Health aan de medische faculteit van het Imperial College London,

Verenigd Koninkrijk, waar het hoofd van de kanker onderzoekslijn van

het Julius Centrum, Petra Peeters, voor 1 dag in de week als professor is

aangesteld.

Geestelijke Gezondheid

De sectie psychiatrische epidemiologie van het Julius Centrum onder-

zoekt psychiatrische ziekten en de daaraan gerelateerde comorbiditeit in

eerstelijns zorg en onder de bevolking in het algemeen. Het onderzoek

kan worden onderverdeeld in drie aandachtsgebieden:

1 Presentatie van depressie in eerstelijns zorg en de relatie met

lichamelijke ziekten zoals dementie, diabetes, maag-darmziekten en

vaatziekten

2 Functionele ziekten en somatoforme aandoeningen

3 Psychiatrische morbiditeit gerelateerd aan sociodemografische

context en consultatie patronen.

De benadering van het onderzoek van het fenomeen somatische psychi-

atrische co-morbiditeit op verschillende niveau’s van het systeem van de

gezondheidszorg is uniek. De meeste onderzoeksprojecten worden uitge-

voerd in samenwerking met partners in de eerstelijns- of tweedelijns

gezondheidszorg, en vaak in samenwerking met andere (internationale)

academische centra.

Theoretische Epidemiologie en Biostatistiek

Het Julius Centrum richt zich op het ontwikkelen van de theorie en

methodologie van epidemiologisch onderzoek. Theoretische epidemio-

logie houdt zich bezig met onderzoek naar het verbeteren van bestaande


methoden en ontwikkelt innovatieve methoden voor de opzet en analyse

van epidemiologische studies.

De verbetering van bestaande methoden voor de opzet en analyse van

multivariabel diagnostisch en prognostisch onderzoek is vrij uniek. De

methoden worden niet alleen bestudeerd op een puur theoretisch

niveau, maar worden tevens toegepast door gebruik van empirische data

van verschillende medische disciplines binnen het Julius Centrum en

van andere grootschalige studies binnen het UMC Utrecht.

Samenwerkingsverbanden

Het Julius Centrum heeft een groot netwerk en heeft een groot aantal

structurele samenwerkingsverbanden. Meerdere mensen hebben hun

persoonlijke naam verbonden aan het centrum via een ereaanstelling.

Binnen het UMC Utrecht zijn gecombineerde aanstellingen van perso-

neel bij verschillende disciplines gerealiseerd om zo een nauw contact te

realiseren met de klinische praktijk bij zowel het formuleren van onder-

zoeksvragen, het uitvoeren van onderzoek als de implementatie van

verworven kennis. Er zijn nauwe banden met alle epidemiologische

onderzoeksgroepen binnen de Universiteit Utrecht zoals IRAS, farmaco-

epidemiologie en veterinaire epidemiologie. Daarnaast zijn er structu-

rele banden met het Rijksinstituut voor Volksgezondheid en Milieu

(RIVM).

Onderzoek in het Julius Centrum wordt uitgevoerd in samenwerking

met onderzoeksinstituten en universiteiten in veel landen. Er bestaan

verscheidene structurele lange termijn samenwerkingsverbanden zoals

de Europese EPIC studie en het GRACE project. Andere vormen van

samenwerking vinden plaats op projectbasis. Momenteel lopen er meer

dan veertig internationale onderzoeksprojecten. Het centrum richt zich


daarnaast op het ontwikkelen van intensieve structurele lange termijn

partnerships met strategisch geselecteerde vooraanstaande en hoogwaar-

dige academische instituten zoals het Imperial College London, Boston

University en het George Institute for International Health in Sydney.

Deze en andere contacten zijn van groot belang bij het verwezenlijken

van de ambitie van het Julius Centrum: voorop blijven lopen in het

internationaal gezondheidswetenschappelijk onderzoek en het versprei-

den van kennis onder een internationaal publiek van studenten en

gezondheidsprofessionals.

IRAS

Het Institute for Risk Assessment Sciences (IRAS) is een interfacultair

onderzoeksinstituut binnen de Universiteit Utrecht dat zich bezighoudt

met interdisciplinair onderzoek dat zich richt op het vaststellen van risi-

co’s van chemische, natuurlijke en biologische middelen op de mens en

zijn omgeving. Het onderzoek wordt uitgevoerd binnen drie divisies:

Environmental Epidemiology, Toxicology en Veterinary Public Health.

De inbreng van de IRAS in samenwerkingsprojecten heeft betrekking op

‘exposure assessment’ methodologie en geavanceerde ‘exposure response’

modellering.

UU Research Focus Area Epidemiology & the Utrecht Centre for

Infection Dynamics (UCID)

Gebaseerd op de aandachtsgebieden van de faculteit, heeft de

Universiteit Utrecht 15 thematische onderzoeksclusters geselecteerd.

Deze aandachtsgebieden bestaan uit multidisciplinaire clusters die voor-

aanstaande onderzoeksgroepen uit elk thematisch veld samenbrengen.

Eén van deze vijftien gebieden is epidemiologie waarin epidemiologische

onderzoeksgroepen samenwerken.


Onderwijs

Het Julius Centrum neemt deel aan een grote hoeveelheid onderwijspro-

gramma’s in een breed scala aan gezondheidswetenschappen en eerste-

lijns zorg. Het centrum neemt actief deel aan nieuwe ontwikkelingen op

het gebied van onderwijs, zoals het ambitieuze undergraduate medicine

program (CRU’99) van het UMC Utrecht, gestart in 1999 en gebaseerd

op interdisciplinair probleem-georiënteerd leren en aan SUMMA, een

nieuw 4-jarig master programma dat startte in 2004. Het merendeel van

de onderwijsprogramma’s wordt gegeven samen met andere divisies bin-

nen of buiten het UMC Utrecht. Het centrum is de basis van het enige

Nederlandse graduate programma voor verplegingswetenschap. Het

centrum is onder andere ook verantwoordelijk voor de specialistenoplei-

ding tot huisarts voor artsen in een driejarige vakopleiding. Speciaal is

ook het nieuwe opleidingsprogramma voor een master titel in de epide-

miologie dat in 2004 werd opgestart samen met andere faculteiten van

de Universiteit Utrecht. Onderwijs voor onderzoekers van het Julius

Centrum vindt plaats door middel van deelname aan erkende graduate

schools zoals het Nihes (Netherlands Institute of Health Science).

Contracten met het management van het Nihes leidden tot een intensie-

vere samenwerking op het gebied van marketing en werving van master

studenten en een voorstel voor een gezamenlijke website voor de

Masteropleiding in Epidemiologie programma. Elk jaar groeit het aantal

onderwijsprogramma’s en dit jaar is een nieuw programma ontwikkeld

voor het medisch curriculum (Medical Humanities) dat is opgenomen

in het curriculum vanaf september 2008.

Huisartsgeneeskunde is een belangrijke specialisatie in Nederland. De

medewerkers van Huisartsgeneeskunde in het Julius Centrum nemen

deel aan diverse onderwijsprogramma’s en geven cursussen op verschil-


lende niveau’s in de basis van het medisch curriculum (Bachelor,

Master). Daarnaast is er een vakopleiding (Post-Graduate) en doorlo-

pend medisch onderwijs. Ook neemt het Julius Centrum actief deel aan

de Bachelor, Master, Post-Graduate/vakopleiding (waar van toepassing)

en vervolgopleidingen op het gebied van Epidemiologie, Public Health,

Biostatistiek, Medical Humanities, Verplegingswetenschap en

Voedingswetenschap.

Binnen het onderwijs vinden verschillende internationale activiteiten

plaats. Deze variëren van het uitnodigen van internationale gastsprekers

en het onderbrengen van internationale studenten tot het organiseren

van onderwijsactiviteiten in het buitenland. Verschillende onderwijsacti-

viteiten in het Julius Centrum zijn Engelstalig en trekken buitenlandse

studenten aan, zoals het MSc programma Epidemiologie of de cursussen

die worden georganiseerd in het door de EU gefinancierde Interact pro-

gramma. Daarnaast verzorgde het Julius Centrum in 2008 verschillende

klinische epidemiologie cursussen in landen zoals Maleisië, Indonesië,

Japan, Canada en de VS.


Patiëntenzorg

Voedingswetenschap en Diëtetiek

De afdeling Voedingswetenschap en Diëtetiek bestaat uit twee groepen.

Voedingswetenschap heeft als hoofdactiviteit onderwijs, onderzoek en

advies op het gebied van kwaliteitszorg. Diëtetiek richt zich op patiën-

tenzorg en het verbeteren van patiëntenzorg.

Voedingswetenschap richt zich op het verbeteren van de integratie van

evidence-based voedingsinterventies in de geneeskunde. In het doorlo-

pend onderwijs aan (para)medische professionals werd voorzien door

bijdragen aan vakbladen en lezingen op nationale congressen. Voor

onderzoeksdoeleinden werd een voedsel-frequentie vragenlijst verbeterd

en is men bezig deze vragenlijst online beschikbaar te maken.

Diëtetiek voorziet in en verbetert patiëntenzorg in het UMC Utrecht en

het revalidatiecentrum ‘De Hoogstraat’. Diëtetiek is landelijk koploper

op het gebied van evidence-based diëtetiek en gestandaardiseerde pro-

cessen voor diëtetiek professionals. De implementatie van een elektro-

nisch patiëntendossier in 2007 verliep voorspoedig en was de start van

een proces van innovatie en efficiëntie. In de loop van 2008 werd het sys-

teem op meerdere punten verbeterd en werden verbindingen gemaakt

met andere elektronische dossiers in het UMC Utrecht. Eveneens werd

er een automatische correspondentie naar specialisten en partners in de

eerstelijns zorg, andere ziekenhuizen en verzorgingstehuizen ontwikkeld.

Daarnaast nam de sectie Diëtetiek deel aan een groot aantal externe

(internationaal, nationaal en regionaal) en interne projecten, workshops,

presentaties en cursussen.


Academische eerstelijns zorg: Julius gezondheidscentra Leidsche Rijn

Sinds januari 2004 heeft het Julius Centrum een netwerk voor academi-

sche patiëntenzorg, gesitueerd in het recent ontwikkelde Utrechtse dis-

trict ‘Leidsche Rijn’. In de komende paar jaar zal Leidsche Rijn uitbreiden

naar een groter voorstedelijk gebied met ongeveer 80.000 inwoners.

Eén van de ambities van het Julius Centrum is het creëren van een aca-

demische omgeving in de eerstelijns zorg waar onderzoek en medisch

onderwijs worden gecombineerd met hoogwaardige, innovatieve patiën-

tenzorg. Om dit te bewerkstelligen heeft het Julius Centrum de ontwik-

keling van eerstelijns zorgfaciliteiten in Leidsche Rijn, het VINEX gebied

van Utrecht, sinds 2004 aangestuurd. In 2008 werden meer dan 20.000

inwoners voorzien van eerstelijns zorgdiensten vanuit de vier Julius

gezondheidscentra. Hiervoor hadden de Julius gezondheidscentra 20

huisartsen, 10 fysiotherapeuten en ondersteunend verplegend en admi-

nistratief personeel in dienst.

In 2008 gingen de centra de volgende fase in hun academische ontwik-

keling in, hetgeen uiteindelijk zal leiden tot een volledige implementatie

van de academische infrastructuur in 2012.

Unit Innovations in Health Services

De unit richt zich op onderzoek naar geïntegreerde zorg en ziektebeheer

en onderzoek naar hulpdiensten. In 2008 groeide de unit van 17 naar 25

fulltime professionele medewerkers. De unit verkreeg zes toewijzingen

voor onderzoek uit diverse fondsen en was betrokken bij tien congressen

en zeven cursussen. Daarnaast werden er twee proefschriften, elf publi-

caties en vele rapporten gepubliceerd. Over 2008 had de unit een positief

financieel resultaat.


Operationele ondersteuning

Management Support

De kernactiviteiten van het Julius Centrum, onderzoek, onderwijs en

patiëntenzorg, worden ondersteund door een aantal diensten. Het

management wordt ondersteund door een centrale financiële afdeling,

een P&O afdeling en een ICT afdeling. Het Julius Centrum is in hoge

mate afhankelijk van externe fondsen zoals die van de European Counsel

en van Nederlandse onderzoeksfondsen zoals ZonMw. De Julius

Centrum website is verder vernieuwd in 2008.

Van CTSU naar Julius Clinical Research en Research Support

In het eerste half jaar van 2008 hield de Clinical Trial Services Unit

(CTSU) net zoals in de jaren daarvoor zich bezig met project manage-

ment, monitoring, een researchkliniek, kwaliteitsborging, een helpdesk

en in het voorzien van een technische infrastructuur voor het verzame-

len, verwerken en analyseren van data. Aan het einde van 2008 werd ech-

ter gestart met de overdracht van een gedeelte van de clinical trial activi-

teiten, te weten project management en klinische monitoring, aan Julius

Clinical Research (JCR), een nieuw opgerichte onafhankelijke academi-

sche trial organisatie. Research support diensten zoals onderzoekskli-

niek, data management, kwaliteitsborging en het Vascular Imaging

Centrum blijven deel uitmaken van het Julius Centrum.

Clinical Trial and Services Unit (CTSU)

CTSU bestond tot het najaar van 2008. CTSU diensten waren beschik-

baar voor interne (Julius Centrum) en externe sponsors. Externe spon-

sors konden andere divisies van het UMC Utrecht, farmaceutische en

voedingsbedrijven of andere wetenschappelijk instituten (RIVM, TNO,


NVI) zijn. De diverse onderdelen van CTSU werden in 2008 opnieuw

gecertificeerd volgens ISO 9001:2000.

Research Support

Onderzoekskliniek

De onderzoekskliniek is een out-patient onderzoekscentrum dat volledig

is uitgerust met moderne klinische en diagnostische faciliteiten voor het

uitvoeren van klinische trials in overeenstemming met GCP richtlijnen.

De onderzoekskliniek was in 2008 betrokken bij 25 studies.

Data Management

Data Management voorziet in gegevensbeheer van hoogwaardige kwali-

teit volgens GCP normen om het verzamelen, verwerken, beheren en

analyseren van epidemiologische gegevens te vergemakkelijken. Deze

diensten zijn beschikbaar voor een brede groep klanten: onderzoekers

van het Julius Centrum en de onderzoekskliniek, onderzoekers van

andere UMC Utrecht divisies en externe partijen. Aan het einde van

2008 liepen er ongeveer 90 projecten binnen deze afdeling.

Kwaliteitsborging

Het Julius Centrum voorziet in diensten in klinisch onderzoek die in

overeenstemming zijn met ICH-GCP en andere van toepassing zijnde

richtlijnen en wetgeving. Het Julius Centrum is verantwoordelijk voor

het Quality Assurance Systeem voor klinische drug trials uitgevoerd in

het UMC Utrecht (Bureau Kwaliteitsborging Onderzoek - BKO).

Vascular Imaging Center

Het VIC is een laboratorium faciliteit die een aantal vasculaire metingen,

met nadruk op ultrasone technieken, ondersteunt. De activiteiten van

het VIC omvatten onder andere de ontwikkeling van meetprotocollen,


advies over apparatuur, het uitvoeren van feitelijke metingen, training

op locatie en certificering. Sinds de start van het VIC in 1997 zijn er

meer dan 20.000 vasculaire metingen bij ongeveer 6.500 patiënten uitge-

voerd.

Julius Clinical Research B.V.

In juli 2008 werd Julius Clinical Research B.V. opgericht. Deze organisa-

tie profileert zichzelf als een academische CRO (ARO), die zich wijdt aan

het leveren van klinische trials van hoogwaardige kwaliteit aan zowel de

farmaceutische industrie als de academische wereld. In 2008 werden

contract onderhandelingen gestart en met succes afgerond tussen het

UMC Utrecht en Wyeth Pharmaceuticals voor het uitvoeren van een

mega-trial op het gebied van infectieziekten: de CAPiTA trial. Door de

snelle gang van zaken werd besloten om de CTSU staf pas in de eerste

helft van 2009 over te laten gaan naar Julius Clinical Research.


Tot slot

De overeenkomstige onderdelen van het jaarverslag gaan dieper in op de

bovengenoemde onderwerpen. Daarnaast geeft het jaarverslag informa-

tie over de medewerkers van het Julius Centrum, de financiële stand van

zaken, lopende onderzoeksprojecten en niet te vergeten de publicaties

van 2008.


Colophon

Editor: Mireille Donkervoort, Manon Kluijtmans

Production: Hellen Braun, Giene de Vries

Design and lay out: Frank Boesveld, Multimedia, UMC Utrecht

Photography: Chris Timmers, Multimedia, UMC Utrecht

Printing: ZuidamUithof drukkerijen, Utrecht

Circulation: 1000

August 2009



Management Team

Organizational structure

Chair: Prof DE Grobbee, MD PhDDirector of Research: Prof AW Hoes, MD PhDDirector of Education: Prof Y van der Graaf, MD PhDDirector of Business and Operations: M van der Starre, MSc (until August 2008)Ir BC van Lieshout (until 31 Dec 2008)Executive Secretary:M Kluijtmans, PhD

Clinical Epidemiology Coordinator: Prof Y van der Graaf, MD PhD

Leidsche Rijn, Julius Health Care CentersDirector: RAE van Damme, MD

Unit Health Care Innovations Head: Prof AJP Schrijvers, PhD

DieteticsHead: M de Bruin

Clinical Trial Services UnitHead: AAA Bak, MD PhD- Project Management Head: AAA Bak, MD PhD- Vascular Imaging Center Head: KM Nijssen- Monitoring Head: IEM Sikking- Site Management Head: L Vendrig

Data ManagementHead: RER Veen, MSc

Management Support Head: M van der Starre, MSc (until August 2008) Ir BC van Lieshout (a.i.)- Finances Head: MH Bekkers - ICT Head: RER Veen, MSc- P&O JJ Molenaar- Facilities Space Manager: JH ter Keurs- Communication M van der Werff

Research Theme: Cardiovascular Diseases Coordinator: ML Bots, MD PhD / YT van der Schouw, PhD

Theme: Infectious Diseases Coordinator: Prof MJM Bonten, MD PhD

Theme: Cancer Coordinator: Prof PHM Peeters, MD PhD

Theme: Mental Health Coordinator: NJ de Wit, MD PhD

Theme: Theoretical Epidemiology and Biostatistics Coordinator: Prof KGM Moons, PhD

Education

Courses:

Patient Care

OperationalSupport

MSc Epidemiology

Medical School / Bachelor and Master Programmes / Research Schools / Postgraduate Education

Coordinator: GJMG van der Heijden, PhD

Coordinator: HM Pieters, MD PhD

Coordinator: RW Haneveld, PHS MPH

Coordinator: JJ van der Bijl, PhD

Coordinator: JA Iestra, PhD

Coordinator: CLJJ Kruitwagen, MSc

Full Curricula: MSc Nursing ScienceGeneral Practice Vocational Training

Biostatistics Coordinator: vacancy

NutritionalSciences

Nursing Scienceuntil mid 2008

Public Health / MTA / Medical EthicsCoordinator:PH: Prof AJP Schrijvers, PhDMTA: GA de Wit, PhDMedical Ethics: Prof JJM van Delden, MD, PhD

General PracticeCoordinator: Prof ThJM Verheij, MD PhD


Julius Center for Health Sciences

and Primary Care

Address:

Heidelberglaan 100

3584 CX Utrecht

The Netherlands

Correspondence:

P.O. Box 85500

3508 GA Utrecht

The Netherlands

Phone +31 (0)88 75 681 81

Fax +31 (0)88 75 680 99

[email protected]

www.umcutrecht.nl

www.juliuscenter.nl

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