annual meeting program · 2019-04-02 · follow #apsateb find aps at eb aps info hub stop by...

Orange County Convention Center

Orlando, FL

April 6-9, 2019

#ExpBio | exper imentalbiology.org | apsebmeeting.org | #APSatEB

ORLANDO

AMERICAN PHYSIOLOGICAL SOCIET Y

ANNUAL MEET ING PROGRAM

FOLLOW #APSatEB

FIND APS AT EB

APS INFO HUBStop by between sessions to ask questions or take a

break.

Outside Room W311

APS SOCIAL HUBSit and chat, snap a pic and

make new connections. Join us daily at lunchtime (approx. 12:15–1:15 p.m.) for a snack and Q&A with

2019 APS conference representatives.

Within the APS Poster Area

APS EXHIBIT BOOTHTalk with us about how we

can further your science and your career.

Exhibit Hall Booth #1341

Find APS at EB 2019.indd 1 3/18/2019 11:09:51 AM

#APS

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tsMe

WITH MEMBERSHIP COMES

COMMUNITYThe American Physiological Society (APS) is a community that champions the discipline of physiology. You’re only a few steps away from unlocking extensive resources and support for your science. Stop by the APS booth #1341 to join our global community. Membership representatives will also be available at the Info Hub (outside room W311) and the Social Hub (in the APS Poster Area).

Explore more benefits or apply online at the-aps.org/benefits.

“APS has become like a family to

me.”—

Sue Bar

man

, APS M

ember

Mich

igan

State

Unive

rsity

Membership Ad.indd 1 3/18/2019 2:00:18 PM

FOLLOW #APSatEB

FIND APS AT EB

APS INFO HUBStop by between sessions to ask questions or take a

break.

Outside Room W311

APS SOCIAL HUBSit and chat, snap a pic and

make new connections. Join us daily at lunchtime (approx. 12:15–1:15 p.m.) for a snack and Q&A with

2019 APS conference representatives.

Within the APS Poster Area

APS EXHIBIT BOOTHTalk with us about how we

can further your science and your career.

Exhibit Hall Booth #1341

Find APS at EB 2019.indd 1 3/18/2019 11:09:51 AM

BUILDING THE FUTURE OF APS (AND PHYSIOLOGY)This presentation provides an opportunity for members to meet Scott Steen, the new APS executive director, and learn about his plans for moving the Society forward.

Saturday, April 6, 2019 5–6 p.m. Orange County Convention Center, Room W314

Join us for a brief reception at 5 p.m. Limited drink tickets will be provided on a first come, first served basis.

Future of APS and Physiology Ad.indd 1 3/7/2019 10:00:54 AM

PROGRAM 2019 | 1

PROGRAM AT-A-GLANCE

Saturday, April 6 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2

Sunday, April 7 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .4

Monday, April 8 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10

Tuesday, April 9 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18

ORAL SESSIONS

Saturday, April 6 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .24

Sunday, April 7 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .33

Monday, April 8 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .57

Tuesday, April 9 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .78

POSTER SESSIONS

Sunday, April 7 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .100

Monday, April 8 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 103

Tuesday, April 9 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .106

Late-Breaking Posters . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .108

SPECIAL EVENTS

All Days . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109

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TABLE OF CONTENTS:

2 | ANNUAL MEETING

PROGRAM AT-A-GLANCE:SATURDAY, APRIL 6

Time Location Session # Sponsor Session/Chair

8:00 AM - 12:00 PM OCCC, W314 50 EDUBeyond the Weight Room: The Importance of Skeletal Muscle in Health and Disease (Supported by APS Strategic Partner ADInstruments MERRITT, DUROCHER

9:00 AM - 5:00 PM Hyatt, Plaza Intl Ballroom H 51 ETG ETG Pre EB Meeting

9:30 AM - 11:30 AM OCCC, W315 52 MCSMCS President’s Symposium: Clinical Perspectives on the MicrocirculationPIERCE-COTTLER, MENDELSON

12:00 PM - 1:00 PM OCCC, W308AB 53 MCS MCS Mentoring Lunch

1:00 PM - 3:00 PM OCCC, W311EF 54APS-ASPET Presidential Symposia Series: Microbiome. Workshop on Microbiome Research: What You Need to KnowPATTERSON, HULLAR

1:00 PM - 2:30 PM OCCC, W308CD 55 AFMRAlzheimer’s Disease: Many Failed Trials so Where Do We Go from Here?REISS, STECKER

1:00 PM - 3:00 PM OCCC, W309AB 56 SPC

A Role for Professional Societies in Addressing and Preventing Sexual Harassment in the Sciences (Cosponsored by APS Women in Physiology Committee)GOULOPOULOU, WILSON

1:00 PM - 3:00 PM OCCC, W315 57 MCSMicrocirculation’s Contribution to Organ FailureBEYER, HALABI

1:00 PM - 5:00 PM OCCC, W311H 58 POG 6th Annual PG Conference

2:00 PM - 5:00 PM Hyatt, Plaza Intl Ballroom G 59 WEHWater and Electrolyte Trainee Award Finalists and Data DiuresisCUNNINGHAM, LORIA

3:00 PM - 4:30 PM OCCC, W308CD 60 AFMRNew Method and Models to Study Human Metabolism with Stable Isotope TracersCREE-GREEN, PARKS

3:00 PM - 5:00 PM OCCC, W311G 61 NCARData NCARnationMILLER, BLACKMORE

3:15 PM - 5:15 PM OCCC, W311EF 62Writing Good Multiple Choice Questions: A Hands-On Workshop (Cosponsored by American Association of Anatomists)SILVERTHORN

3:30 PM - 5:30 PM OCCC, W315 63 MCSEmerging Topics: Adaptation of Microvessels and LymphaticsBRESLIN, MAC GABHANN

5:30 PM - 6:00 PM OCCC, W314 64 Building the Future of APS (and Physiology)STEEN

PROGRAM 2019 | 3



8:00 AM - 12:00 PM OCCC, W314 50 EDUBeyond the Weight Room: The Importance of Skeletal Muscle in Health and Disease (Supported by APS Strategic Partner ADInstruments MERRITT, DUROCHER

9:00 AM - 5:00 PM Hyatt, Plaza Intl Ballroom H 51 ETG ETG Pre EB Meeting

9:30 AM - 11:30 AM OCCC, W315 52 MCSMCS President’s Symposium: Clinical Perspectives on the MicrocirculationPIERCE-COTTLER, MENDELSON

12:00 PM - 1:00 PM OCCC, W308AB 53 MCS MCS Mentoring Lunch

1:00 PM - 3:00 PM OCCC, W311EF 54APS-ASPET Presidential Symposia Series: Microbiome. Workshop on Microbiome Research: What You Need to KnowPATTERSON, HULLAR

1:00 PM - 2:30 PM OCCC, W308CD 55 AFMRAlzheimer’s Disease: Many Failed Trials so Where Do We Go from Here?REISS, STECKER

1:00 PM - 3:00 PM OCCC, W309AB 56 SPC

A Role for Professional Societies in Addressing and Preventing Sexual Harassment in the Sciences (Cosponsored by APS Women in Physiology Committee)GOULOPOULOU, WILSON

1:00 PM - 3:00 PM OCCC, W315 57 MCSMicrocirculation’s Contribution to Organ FailureBEYER, HALABI

1:00 PM - 5:00 PM OCCC, W311H 58 POG 6th Annual PG Conference

2:00 PM - 5:00 PM Hyatt, Plaza Intl Ballroom G 59 WEHWater and Electrolyte Trainee Award Finalists and Data DiuresisCUNNINGHAM, LORIA

3:00 PM - 4:30 PM OCCC, W308CD 60 AFMRNew Method and Models to Study Human Metabolism with Stable Isotope TracersCREE-GREEN, PARKS

3:00 PM - 5:00 PM OCCC, W311G 61 NCARData NCARnationMILLER, BLACKMORE

3:15 PM - 5:15 PM OCCC, W311EF 62Writing Good Multiple Choice Questions: A Hands-On Workshop (Cosponsored by American Association of Anatomists)SILVERTHORN

3:30 PM - 5:30 PM OCCC, W315 63 MCSEmerging Topics: Adaptation of Microvessels and LymphaticsBRESLIN, MAC GABHANN

5:30 PM - 6:00 PM OCCC, W314 64 Building the Future of APS (and Physiology)STEEN

4 | ANNUAL MEETING



6:00 PM - 7:00 PM OCCC, Chapin Theater 65 Tang Prize AwardDRUCKER

6:00 PM - 8:00 PM OCCC, W308AB 66 MCSMCS Poster Discussion and ReceptionLEBLANC

SUNDAY, APRIL 7


7:00 AM - 8:00 AM OCCC, W311C 147 WIPCCareer Planning: No Scientist Left Behind (Sunday)NICOLS, RANDIVE

7:00 AM - 8:00 AM OCCC, W311B 148 TACMarketing Yourself for a Successful Career IOBI, ZARATE

7:00 AM - 8:00 AM OCCC, W311D 149 COPCThe Hidden Job: Skills for a Career in PhysiologyBECKER, TRIMBY

8:30 AM - 10:00 AM OCCC, W309AB 150 PUBSPublishing 101SIGMUND, SCHEMAN

8:30 AM - 10:00 AM OCCC, W311EF 151 EBSSAquaporins: More than Water under the BridgeMAMENKO, ILATOVSKAYA

8:30 AM - 10:00 AM OCCC, W308CD 152 RESPCentral Control of Breathing: Gliocentric MechanismsFUNK, MULKEY

8:30 AM - 10:00 AM OCCC, W311C 153 EEPExercise and Heat Therapy: Shared Molecular Targets and Cardiometabolic BenefitsMINSON

8:30 AM - 10:00 AM OCCC, W311H 154 CVSNeurodegeneration and Heart Failure: An intimate ConnectionDEL MONTE, WOLD

8:30 AM - 10:00 AM OCCC, W311D 155 WEHTranslational Models of Renal and Cardiovascular Disease: Informing Human Health or Not?HARRISON-BERNARD, OSBORN

PROGRAM 2019 | 5



6:00 PM - 7:00 PM OCCC, Chapin Theater 65 Tang Prize AwardDRUCKER

6:00 PM - 8:00 PM OCCC, W308AB 66 MCSMCS Poster Discussion and ReceptionLEBLANC

SUNDAY, APRIL 7


7:00 AM - 8:00 AM OCCC, W311C 147 WIPCCareer Planning: No Scientist Left Behind (Sunday)NICOLS, RANDIVE

7:00 AM - 8:00 AM OCCC, W311B 148 TACMarketing Yourself for a Successful Career IOBI, ZARATE


8:30 AM - 10:00 AM OCCC, W309AB 150 PUBSPublishing 101SIGMUND, SCHEMAN

8:30 AM - 10:00 AM OCCC, W311EF 151 EBSSAquaporins: More than Water under the BridgeMAMENKO, ILATOVSKAYA

8:30 AM - 10:00 AM OCCC, W308CD 152 RESPCentral Control of Breathing: Gliocentric MechanismsFUNK, MULKEY

8:30 AM - 10:00 AM OCCC, W311C 153 EEPExercise and Heat Therapy: Shared Molecular Targets and Cardiometabolic BenefitsMINSON

8:30 AM - 10:00 AM OCCC, W311H 154 CVSNeurodegeneration and Heart Failure: An intimate ConnectionDEL MONTE, WOLD

8:30 AM - 10:00 AM OCCC, W311D 155 WEHTranslational Models of Renal and Cardiovascular Disease: Informing Human Health or Not?HARRISON-BERNARD, OSBORN

6 | ANNUAL MEETING

PROGRAM AT-A-GLANCE:SUNDAY, APRIL 7


8:30 AM - 10:00 AM OCCC, W311G 156 CVSCardiac ECM Niche in Health and DiseaseDIXON, GRIFFITHS

8:30 AM - 10:00 AM OCCC, W312B 157 TEACHInnovative Techniques for Teaching Health Sciences to Increase Retention and Mastery LearningJONES, ELSAYED

8:30 AM - 10:00 AM OCCC, W308AB 158 MCS/CVKaley Award Featured Topic: The Microcirculation and Its Many Cells that Contribute to Tissue RepairKUBES

8:30 AM - 10:00 AM OCCC, W311B 159 NCARNCAR Young Investigator Awards Featured TopicXU, DEL RIO

8:30 AM - 10:00 AM OCCC, W311A 160 RENALRenal Section Young Investigator Award Featured Topic: At the Nexus of Circadian Biology and Renal PhysiologyGUMZ, WINGO

8:30 AM - 10:00 AM OCCC, W312A 161 CEPSTrainee SessionCROSSLEY

8:30 AM - 10:00 AM OCCC, W314 162APS-ASPET Presidential Symposia Series: Microbiome. Gut Microbiome and Metabolic DisordersSANDS, MORGAN

12:00 PM - 1:30 PM Hyatt, Plaza Intl Ballroom D 163Bodil M. Schmidt-Nielsen Distinguished Mentor Award Lecture (Sponsored by Novo Nordisk Foundation)WAGNER

1:30 PM - 3:00 PM OCCC, W309AB 164 CNSInteraction of Cardiovascular Disease and Neuro-Cognitive ImpairmentWALLACE, STOCKER

1:30 PM - 3:00 PM OCCC, W308AB 165 POGMetagenomic and Metabolomic Studies of Host-Microbiotal Contributions to Health and DiseaseJOE, ABAIS-BATTAD

1:30 PM - 3:00 PM OCCC, W311B 166 PICSGLT2 Inhibitors: From Basic Physiology to Clinical SuccessGONZALEZ VILLALOBOS, PATI

1:30 PM - 3:00 PM OCCC, W311G 167 CVSSurvived a Complicated Pregnancy? Maternal, Postpartum and Fetal Cerebrovascular RisksWARRINGTON, CIPOLLA

1:30 PM - 3:00 PM OCCC, W308CD 168 HYPOXThe Lahiri/Cherniak Lecture SymposiumWILSON

1:30 PM - 3:00 PM OCCC, W314 169 EEPThe Role of Skeletal Muscle Damage in Adaptive RemodelingMCCARTHY, MURACH

PROGRAM 2019 | 7



8:30 AM - 10:00 AM OCCC, W311G 156 CVSCardiac ECM Niche in Health and DiseaseDIXON, GRIFFITHS

8:30 AM - 10:00 AM OCCC, W312B 157 TEACHInnovative Techniques for Teaching Health Sciences to Increase Retention and Mastery LearningJONES, ELSAYED

8:30 AM - 10:00 AM OCCC, W308AB 158 MCS/CVKaley Award Featured Topic: The Microcirculation and Its Many Cells that Contribute to Tissue RepairKUBES

8:30 AM - 10:00 AM OCCC, W311B 159 NCARNCAR Young Investigator Awards Featured TopicXU, DEL RIO

8:30 AM - 10:00 AM OCCC, W311A 160 RENALRenal Section Young Investigator Award Featured Topic: At the Nexus of Circadian Biology and Renal PhysiologyGUMZ, WINGO

8:30 AM - 10:00 AM OCCC, W312A 161 CEPSTrainee SessionCROSSLEY

8:30 AM - 10:00 AM OCCC, W314 162APS-ASPET Presidential Symposia Series: Microbiome. Gut Microbiome and Metabolic DisordersSANDS, MORGAN

12:00 PM - 1:30 PM Hyatt, Plaza Intl Ballroom D 163Bodil M. Schmidt-Nielsen Distinguished Mentor Award Lecture (Sponsored by Novo Nordisk Foundation)WAGNER

1:30 PM - 3:00 PM OCCC, W309AB 164 CNSInteraction of Cardiovascular Disease and Neuro-Cognitive ImpairmentWALLACE, STOCKER

1:30 PM - 3:00 PM OCCC, W308AB 165 POGMetagenomic and Metabolomic Studies of Host-Microbiotal Contributions to Health and DiseaseJOE, ABAIS-BATTAD

1:30 PM - 3:00 PM OCCC, W311B 166 PICSGLT2 Inhibitors: From Basic Physiology to Clinical SuccessGONZALEZ VILLALOBOS, PATI

1:30 PM - 3:00 PM OCCC, W311G 167 CVSSurvived a Complicated Pregnancy? Maternal, Postpartum and Fetal Cerebrovascular RisksWARRINGTON, CIPOLLA

1:30 PM - 3:00 PM OCCC, W308CD 168 HYPOXThe Lahiri/Cherniak Lecture SymposiumWILSON

1:30 PM - 3:00 PM OCCC, W314 169 EEPThe Role of Skeletal Muscle Damage in Adaptive RemodelingMCCARTHY, MURACH

8 | ANNUAL MEETING



1:30 PM - 3:00 PM OCCC, W312B 170 TEACHUsing Writing to Teach and Assess Undergraduate Physiology StudentsANDERSON

1:30 PM - 3:00 PM OCCC, W312A 171 CVSAging, Exercise and Heart Failure: Common Connections and New TargetsEMTER, WRANN

1:30 PM - 3:00 PM OCCC, W311D 172 NCARAutonomic Anti-Inflammatory Mechanisms: Which Branch Trumps?HARWANI, PHAM

1:30 PM - 3:00 PM OCCC, W311C 173 ETGHans Ussing Lecture of the Epithelial Transport GroupKEELY, KORTENOEVEN

1:30 PM - 3:00 PM OCCC, W311A 174 CELLpH Homeostasis and Acid-Base TransportPARKER, ROMERO

1:30 PM - 3:00 PM OCCC, W311H 175 EMSex Specific Differences in Obesity Induced HypertensionBARNES, PRIMEAUX

1:30 PM - 3:00 PM OCCC, W311EF 176 TPIGTranslational Physiology HighlightsMCCONNELL, JEONG

3:30 PM - 4:30 PM OCCC, W315 177 WEHErnest Starling Distinguished Lectureship of the Water and Electrolyte Homeostasis SectionPOLLOCK

3:30 PM - 4:30 PM OCCC, W311EF 178 CELLHugh Davson Distinguished Lectureship of the APS Cell and Molecular Physiology SectionDAWSON

3:30 PM - 5:30 PM OCCC, W308AB 179 MCS/CVMCS Landis Award Lecture and Business MeetingHILL

3:30 PM - 5:00 PM OCCC, W311B 180 NCARAutonomic Control of MetabolismAUBERT

3:30 PM - 5:00 PM OCCC, W308CD 181 EBSSCarotid Body Sensing: More than Just an O2 SensorMCFARLANE, BAVIS

3:30 PM - 5:00 PM OCCC, W312A 182 SFiBCommon Pathways of Angiotensin on Cardiovascular and Respiratory Responses Induced by High-Fat-Diet, Hypoxia and Renal Hypertension COLOMBARI, DEL RIO

3:30 PM - 5:00 PM OCCC, W311A 183 EMHormonal Influences on Tissue RemodelingLINDSEY, GOHAR

3:30 PM - 5:00 PM OCCC, W309AB 184 GILInnovative Imaging Approaches in Gastrointestinal Epithelial BiologyEDELBLUM

PROGRAM 2019 | 9



1:30 PM - 3:00 PM OCCC, W312B 170 TEACHUsing Writing to Teach and Assess Undergraduate Physiology StudentsANDERSON

1:30 PM - 3:00 PM OCCC, W312A 171 CVSAging, Exercise and Heart Failure: Common Connections and New TargetsEMTER, WRANN

1:30 PM - 3:00 PM OCCC, W311D 172 NCARAutonomic Anti-Inflammatory Mechanisms: Which Branch Trumps?HARWANI, PHAM

1:30 PM - 3:00 PM OCCC, W311C 173 ETGHans Ussing Lecture of the Epithelial Transport GroupKEELY, KORTENOEVEN

1:30 PM - 3:00 PM OCCC, W311A 174 CELLpH Homeostasis and Acid-Base TransportPARKER, ROMERO

1:30 PM - 3:00 PM OCCC, W311H 175 EMSex Specific Differences in Obesity Induced HypertensionBARNES, PRIMEAUX

1:30 PM - 3:00 PM OCCC, W311EF 176 TPIGTranslational Physiology HighlightsMCCONNELL, JEONG

3:30 PM - 4:30 PM OCCC, W315 177 WEHErnest Starling Distinguished Lectureship of the Water and Electrolyte Homeostasis SectionPOLLOCK

3:30 PM - 4:30 PM OCCC, W311EF 178 CELLHugh Davson Distinguished Lectureship of the APS Cell and Molecular Physiology SectionDAWSON

3:30 PM - 5:30 PM OCCC, W308AB 179 MCS/CVMCS Landis Award Lecture and Business MeetingHILL

3:30 PM - 5:00 PM OCCC, W311B 180 NCARAutonomic Control of MetabolismAUBERT

3:30 PM - 5:00 PM OCCC, W308CD 181 EBSSCarotid Body Sensing: More than Just an O2 SensorMCFARLANE, BAVIS

3:30 PM - 5:00 PM OCCC, W312A 182 SFiBCommon Pathways of Angiotensin on Cardiovascular and Respiratory Responses Induced by High-Fat-Diet, Hypoxia and Renal Hypertension COLOMBARI, DEL RIO

3:30 PM - 5:00 PM OCCC, W311A 183 EMHormonal Influences on Tissue RemodelingLINDSEY, GOHAR

3:30 PM - 5:00 PM OCCC, W309AB 184 GILInnovative Imaging Approaches in Gastrointestinal Epithelial BiologyEDELBLUM

10 | ANNUAL MEETING



3:30 PM - 5:00 PM OCCC, W311D 185 RENALMechanism of Hypertension-Induced Kidney DamageLI, PRIETO

3:30 PM - 5:00 PM OCCC, W312B 186 EEPNrf2 as a Promising Target for Increasing Healthspan and Diminishing Aging-Related Chronic DiseasesHAMILTON

3:30 PM - 5:00 PM OCCC, W311C 187 NPIGNutrition as a Biological Variable: Considerations for the Future of Physiology ResearchANTHONY, BAUM

3:30 PM - 5:00 PM OCCC, W311H 188 SGRIGSex and Metabolic Health: Emerging Challenges and DiscoveriesALEXANDER, RICE

3:30 PM - 5:00 PM OCCC, W311G 189 RESPSex and Gender in Respiratory PhysiologySILVEYRA, PRAKASH

3:30 PM - 5:00 PM OCCC, Valencia Ballroom D 190 EDU

David Bruce Undergraduate Poster Session and Horwitz/Horowitz Awards CeremonyOSBORN

4:30 PM - 5:00 PM OCCC, W315 191 WEHWater and Electrolyte New Investigator Award LectureHULSTROM

5:15 PM - 5:40 PM OCCC, W314 192 APS Business Meeting

5:40 PM - 6:30 PM OCCC, W314 193 Physiology in Perspective: The Walter B. Cannon AwardARONSON

MONDAY, APRIL 8


7:00 AM - 8:00 AM OCCC, W311C 279 WIPCCareer Planning: No Scientist Left BehindNICOLS, RANDIVE

7:00 AM - 8:00 AM OCCC, W311B 280 TACMarketing Yourself for a Successful Career IIOBI, ZARATE


PROGRAM 2019 | 11



3:30 PM - 5:00 PM OCCC, W311D 185 RENALMechanism of Hypertension-Induced Kidney DamageLI, PRIETO

3:30 PM - 5:00 PM OCCC, W312B 186 EEPNrf2 as a Promising Target for Increasing Healthspan and Diminishing Aging-Related Chronic DiseasesHAMILTON

3:30 PM - 5:00 PM OCCC, W311C 187 NPIGNutrition as a Biological Variable: Considerations for the Future of Physiology ResearchANTHONY, BAUM

3:30 PM - 5:00 PM OCCC, W311H 188 SGRIGSex and Metabolic Health: Emerging Challenges and DiscoveriesALEXANDER, RICE

3:30 PM - 5:00 PM OCCC, W311G 189 RESPSex and Gender in Respiratory PhysiologySILVEYRA, PRAKASH

3:30 PM - 5:00 PM OCCC, Valencia Ballroom D 190 EDU

David Bruce Undergraduate Poster Session and Horwitz/Horowitz Awards CeremonyOSBORN

4:30 PM - 5:00 PM OCCC, W315 191 WEHWater and Electrolyte New Investigator Award LectureHULSTROM

5:15 PM - 5:40 PM OCCC, W314 192 APS Business Meeting

5:40 PM - 6:30 PM OCCC, W314 193 Physiology in Perspective: The Walter B. Cannon AwardARONSON

MONDAY, APRIL 8


7:00 AM - 8:00 AM OCCC, W311C 279 WIPCCareer Planning: No Scientist Left BehindNICOLS, RANDIVE

7:00 AM - 8:00 AM OCCC, W311B 280 TACMarketing Yourself for a Successful Career IIOBI, ZARATE


12 | ANNUAL MEETING

PROGRAM AT-A-GLANCE:MONDAY, APRIL 8


8:30 AM - 9:30 AM OCCC, W309AB 282 TEACHClaude Bernard Distinguished Lectureship of the APS Teaching of Physiology Section (Supported by APS Strategic Partner ADInstruments)WENDEROTH

8:30 AM - 9:30 AM OCCC, W308AB 283 CVSRobert M. Berne Distinguished Lectureship of the APS Cardiovascular SectionTIAN

8:30 AM - 10:00 AM OCCC, W311C 284 TPIGDiabetes: A Metabolic KarmaCARRILLO SEPULVEDA, CHEN

8:30 AM - 10:00 AM OCCC, W311G 285 NCARNeural Circulatory Mechanisms Linking Sleep Loss to HypertensionLIMBERG, SOMERS

8:30 AM - 10:00 AM OCCC, W311EF 286 EBSSOxidative Stress and Post-translational Modification of Protein Thiols in Cell SignalingHELMS, DOWNS

8:30 AM - 10:00 AM OCCC, W308CD 287 EEPEEP Impact Award Featured Topic: Modulation of Systemic and Tissue Metabolism via Differences in Activity and FitnessMORRIS, RECTOR

8:30 AM - 10:00 AM OCCC, W311D 288 CNSEffects of Diet on Emotion and Motivated BehaviorSILBERMAN, BARSON

8:30 AM - 10:00 AM OCCC, W311H 289 RESPMapping The Lung: Leveraging Emerging Technologies To Better Understand Pulmonary DiseaseBEERS, BASTARACHE

8:30 AM - 10:00 AM OCCC, W311A 290 CELLMolecular Mechanisms of Cellular Signaling and TransductionBLAZER-YOST, TEAL

8:30 AM - 10:00 AM OCCC, W312B 291 RESPPerinatal Reprogramming of Respiratory ControlHUXTABLE, BAKER

8:30 AM - 10:00 AM OCCC, W312A 292 MBGHot Topics in Muscle BiologyWANG, MITCH

8:30 AM - 10:00 AM OCCC, W314 293APS-ASPET Presidential Symposia Series: Microbiome. Gut Microbiota: A Chemical FactoryJEONG, PLUZNICK

8:30 AM - 10:00 AM OCCC, W311B 294 WEH and ETGHot Topics in WEH and ETGRIEG, BEGGS

1:30 PM - 2:30 PM OCCC, W308AB 295 NCARCarl Ludwig Distinguished Lectureship of the APS Neural Control and Autonomic Regulation SectionBARMAN

PROGRAM 2019 | 13



8:30 AM - 9:30 AM OCCC, W309AB 282 TEACHClaude Bernard Distinguished Lectureship of the APS Teaching of Physiology Section (Supported by APS Strategic Partner ADInstruments)WENDEROTH

8:30 AM - 9:30 AM OCCC, W308AB 283 CVSRobert M. Berne Distinguished Lectureship of the APS Cardiovascular SectionTIAN

8:30 AM - 10:00 AM OCCC, W311C 284 TPIGDiabetes: A Metabolic KarmaCARRILLO SEPULVEDA, CHEN

8:30 AM - 10:00 AM OCCC, W311G 285 NCARNeural Circulatory Mechanisms Linking Sleep Loss to HypertensionLIMBERG, SOMERS

8:30 AM - 10:00 AM OCCC, W311EF 286 EBSSOxidative Stress and Post-translational Modification of Protein Thiols in Cell SignalingHELMS, DOWNS

8:30 AM - 10:00 AM OCCC, W308CD 287 EEPEEP Impact Award Featured Topic: Modulation of Systemic and Tissue Metabolism via Differences in Activity and FitnessMORRIS, RECTOR

8:30 AM - 10:00 AM OCCC, W311D 288 CNSEffects of Diet on Emotion and Motivated BehaviorSILBERMAN, BARSON

8:30 AM - 10:00 AM OCCC, W311H 289 RESPMapping The Lung: Leveraging Emerging Technologies To Better Understand Pulmonary DiseaseBEERS, BASTARACHE

8:30 AM - 10:00 AM OCCC, W311A 290 CELLMolecular Mechanisms of Cellular Signaling and TransductionBLAZER-YOST, TEAL

8:30 AM - 10:00 AM OCCC, W312B 291 RESPPerinatal Reprogramming of Respiratory ControlHUXTABLE, BAKER

8:30 AM - 10:00 AM OCCC, W312A 292 MBGHot Topics in Muscle BiologyWANG, MITCH

8:30 AM - 10:00 AM OCCC, W314 293APS-ASPET Presidential Symposia Series: Microbiome. Gut Microbiota: A Chemical FactoryJEONG, PLUZNICK

8:30 AM - 10:00 AM OCCC, W311B 294 WEH and ETGHot Topics in WEH and ETGRIEG, BEGGS

1:30 PM - 2:30 PM OCCC, W308AB 295 NCARCarl Ludwig Distinguished Lectureship of the APS Neural Control and Autonomic Regulation SectionBARMAN

14 | ANNUAL MEETING



1:30 PM - 2:30 PM OCCC, W308CD 296 EEPEdward F. Adolph Distinguished Lectureship of the APS Environmental and Exercise Physiology SectionBODINE

1:30 PM - 3:00 PM OCCC, W314 297 2019 Annual Marion J. Siegman Lectureship AwardHARRIS

1:30 PM - 3:00 PM OCCC, W311EF 298 EBSSBrown Adipose Tissue: The Fat that Makes you ThinSYMONDS

1:30 PM - 3:00 PM OCCC, W311C 299 EMCrosstalk between Metabolic Disorders and Mitochondrial Oxidative StressDIKALOV, SACK

1:30 PM - 3:00 PM OCCC, W312B 300 CEPSFrom the Brainstem to the Heart: Cardio-Respiratory Control in Ectothermic VertebratesJANES, CONNER

1:30 PM - 3:00 PM OCCC, W312A 301 CVSThoracic and Abdominal Aortic Aneurysm: From Models and Mechanism to Clinical Trials and Therapy UpdatesKASSIRI, LIU

1:30 PM - 3:00 PM OCCC, W311B 302 HISTUpdating the History of Insulin; Novel Insights into Regulation of Release, Delivery and FunctionsMOLINA, SOUZA-SMITH

1:30 PM - 3:00 PM OCCC, W311D 303 RENALAdvances in Renal Physiology IELLISON, FENG

1:30 PM - 3:00 PM OCCC, W311G 304 CVSCardiovascular Section Young Investigator CompetitionFAULKNER, DORRANCE

1:30 PM - 3:00 PM OCCC, W309AB 305 GILGastrointestinal and Liver Physiology and DiseaseZACHOS, ENGEVIK

1:30 PM - 3:00 PM OCCC, W311H 306 WEHTherapeutic and Adverse Effects of Pharmacological Agents on Integrative Physiology and PathophysiologyLORIA, WOLF

1:30 PM - 3:00 PM OCCC, W311A 307 APS Chapters: Why, How, What of Starting New ChaptersHOPPER

3:30 PM - 4:30 PM OCCC, W308CD 308 CEPSAugust Krogh Distinguished Lectureship of the APS Comparative and Evolutionary Physiology Section (Supported by Novo Nordisk Foundation)WILLIAMS

3:30 PM - 4:30 PM OCCC, W311EF 309 RENALCarl W. Gottschalk Distinguished Lectureship of the APS Renal SectionGOMEZ

PROGRAM 2019 | 15



1:30 PM - 2:30 PM OCCC, W308CD 296 EEPEdward F. Adolph Distinguished Lectureship of the APS Environmental and Exercise Physiology SectionBODINE

1:30 PM - 3:00 PM OCCC, W314 297 2019 Annual Marion J. Siegman Lectureship AwardHARRIS

1:30 PM - 3:00 PM OCCC, W311EF 298 EBSSBrown Adipose Tissue: The Fat that Makes you ThinSYMONDS

1:30 PM - 3:00 PM OCCC, W311C 299 EMCrosstalk between Metabolic Disorders and Mitochondrial Oxidative StressDIKALOV, SACK

1:30 PM - 3:00 PM OCCC, W312B 300 CEPSFrom the Brainstem to the Heart: Cardio-Respiratory Control in Ectothermic VertebratesJANES, CONNER

1:30 PM - 3:00 PM OCCC, W312A 301 CVSThoracic and Abdominal Aortic Aneurysm: From Models and Mechanism to Clinical Trials and Therapy UpdatesKASSIRI, LIU

1:30 PM - 3:00 PM OCCC, W311B 302 HISTUpdating the History of Insulin; Novel Insights into Regulation of Release, Delivery and FunctionsMOLINA, SOUZA-SMITH

1:30 PM - 3:00 PM OCCC, W311D 303 RENALAdvances in Renal Physiology IELLISON, FENG

1:30 PM - 3:00 PM OCCC, W311G 304 CVSCardiovascular Section Young Investigator CompetitionFAULKNER, DORRANCE

1:30 PM - 3:00 PM OCCC, W309AB 305 GILGastrointestinal and Liver Physiology and DiseaseZACHOS, ENGEVIK

1:30 PM - 3:00 PM OCCC, W311H 306 WEHTherapeutic and Adverse Effects of Pharmacological Agents on Integrative Physiology and PathophysiologyLORIA, WOLF

1:30 PM - 3:00 PM OCCC, W311A 307 APS Chapters: Why, How, What of Starting New ChaptersHOPPER

3:30 PM - 4:30 PM OCCC, W308CD 308 CEPSAugust Krogh Distinguished Lectureship of the APS Comparative and Evolutionary Physiology Section (Supported by Novo Nordisk Foundation)WILLIAMS

3:30 PM - 4:30 PM OCCC, W311EF 309 RENALCarl W. Gottschalk Distinguished Lectureship of the APS Renal SectionGOMEZ

16 | ANNUAL MEETING



3:30 PM - 4:30 PM OCCC, W309AB 310 GILHorace W. Davenport Distinguished Lectureship of the APS Gastrointestinal and Liver Physiology SectionLARUSSO

3:30 PM - 4:30 PM OCCC, W311G 311 CNSJoseph Erlanger Distinguished Lectureship of the APS Central Nervous System SectionBALE

3:30 PM - 4:30 PM OCCC, W308AB 312 EMSolomon Berson Distinguished Lectureship of the APS Endocrinology and Metabolism SectionZIERATH

3:30 PM - 5:00 PM OCCC, W311D 313 RESPENaC and Fluid Transport across Airway EpitheliaALTHAUS, BUTTERWORTH

3:30 PM - 5:00 PM OCCC, W311A 314 CELLNew Frontier in Direct Effects of Lipids and Lipid Metabolic Defects on Membrane ProteinsJIANG, GOHIL

3:30 PM - 5:00 PM OCCC, W312A 315 CVSCardiac and Peripheral Vasculopathies: Emerging Biomarkers, Imaging and TreatmentsLEBLANC, KAUFMAN

3:30 PM - 5:00 PM OCCC, W312B 316 RESPEmerging Therapeutics for Respiratory DysfunctionFALK, FERREIRA

3:30 PM - 5:00 PM OCCC, W311H 317 EEPMechanisms Underlying the Greater Propensity for Cardiovascular Disease in Populations with Elevated RiskKELLER, BROTHERS

3:30 PM - 5:00 PM OCCC, W311C 318 CVSWiggers Award Featured TopicCHIEN

3:30 PM - 5:00 PM OCCC, W311B 319 WEHEnvironmental and Epigenetic Contributions to Disease OriginHYNDMAN, LEACHMAN

5:15 PM - 5:40 PM OCCC, W314 320 APS Awards Recognition

5:40 PM - 6:30 PM OCCC, W314 321 Henry Pickering Bowditch AwardPLUZNICK

PROGRAM 2019 | 17



3:30 PM - 4:30 PM OCCC, W309AB 310 GILHorace W. Davenport Distinguished Lectureship of the APS Gastrointestinal and Liver Physiology SectionLARUSSO

3:30 PM - 4:30 PM OCCC, W311G 311 CNSJoseph Erlanger Distinguished Lectureship of the APS Central Nervous System SectionBALE

3:30 PM - 4:30 PM OCCC, W308AB 312 EMSolomon Berson Distinguished Lectureship of the APS Endocrinology and Metabolism SectionZIERATH

3:30 PM - 5:00 PM OCCC, W311D 313 RESPENaC and Fluid Transport across Airway EpitheliaALTHAUS, BUTTERWORTH

3:30 PM - 5:00 PM OCCC, W311A 314 CELLNew Frontier in Direct Effects of Lipids and Lipid Metabolic Defects on Membrane ProteinsJIANG, GOHIL

3:30 PM - 5:00 PM OCCC, W312A 315 CVSCardiac and Peripheral Vasculopathies: Emerging Biomarkers, Imaging and TreatmentsLEBLANC, KAUFMAN

3:30 PM - 5:00 PM OCCC, W312B 316 RESPEmerging Therapeutics for Respiratory DysfunctionFALK, FERREIRA

3:30 PM - 5:00 PM OCCC, W311H 317 EEPMechanisms Underlying the Greater Propensity for Cardiovascular Disease in Populations with Elevated RiskKELLER, BROTHERS

3:30 PM - 5:00 PM OCCC, W311C 318 CVSWiggers Award Featured TopicCHIEN

3:30 PM - 5:00 PM OCCC, W311B 319 WEHEnvironmental and Epigenetic Contributions to Disease OriginHYNDMAN, LEACHMAN

5:15 PM - 5:40 PM OCCC, W314 320 APS Awards Recognition

5:40 PM - 6:30 PM OCCC, W314 321 Henry Pickering Bowditch AwardPLUZNICK

18 | ANNUAL MEETING

PROGRAM AT-A-GLANCE:TUESDAY, APRIL 9


7:00 AM - 8:00 AM OCCC, W311C 399 WIPCCareer Planning: No Scientist Left Behind NICOLS, RANDIVE

7:00 AM - 8:00 AM OCCC, W311B 400 TACMarketing Yourself for a Successful Career IIIOBI, ZARATE


8:30 AM - 10:00 AM OCCC, W311EF 402 EBSSCrosstalk among Myofibers, Microvessels and Motor Nerves during Skeletal Muscle RegenerationSEGAL

8:30 AM - 10:00 AM OCCC, W308AB 403 MBGMuscle-Derived Extracellular Vesicles in the Regulation of Metabolic Health and DiseaseLARK

8:30 AM - 10:00 AM OCCC, W311H 404 RESP Musculoskeletal Afferents and the Control of BreathingSTREETER, FULLER

8:30 AM - 10:00 AM OCCC, W308CD 405 PHYSOC/APS Physiology of Obesity: From Mechanisms to Medicine ALDISS, LEWIS

8:30 AM - 10:00 AM OCCC, W309AB 406 CVSProtein Degradation Mechanisms: A Compartmentalized Affair in Cardiac Muscle and Disease?SHEIKH, LIANG

8:30 AM - 10:00 AM OCCC, W311G 407 RENAL Advances in Renal Physiology IILAYTON, SULLIVAN

8:30 AM - 10:00 AM OCCC, W311B 408 NCAR Autonomic Function in Normal and Preeclamptic PregnanciesSTACHENFELD, USSELMAN

8:30 AM - 10:00 AM OCCC, W311C 409 CVS Cardiovascular Metabolism in DiabetesHILL, HARMANCEY

8:30 AM - 10:00 AM OCCC, W311D 410 EEP Examining Physiological Mechanisms Using Environmental StressorsJOHNSON, SCHLADER

8:30 AM - 10:00 AM OCCC, W311A 411 CELL Ion Channels, Solute and Molecular Transporters In Heath and DiseaseBAINES, ALTHAUS

8:30 AM - 10:00 AM OCCC, W312A 412 GIL John Forte Plenary SessionFREY

8:30 AM - 10:00 AM OCCC, W314 413APS-ASPET Presidential Symposia Series: Microbiome. Microbiota in Action: The Gut and BeyondMCCABE, CUI

PROGRAM 2019 | 19



7:00 AM - 8:00 AM OCCC, W311C 399 WIPCCareer Planning: No Scientist Left Behind NICOLS, RANDIVE

7:00 AM - 8:00 AM OCCC, W311B 400 TACMarketing Yourself for a Successful Career IIIOBI, ZARATE


8:30 AM - 10:00 AM OCCC, W311EF 402 EBSSCrosstalk among Myofibers, Microvessels and Motor Nerves during Skeletal Muscle RegenerationSEGAL

8:30 AM - 10:00 AM OCCC, W308AB 403 MBGMuscle-Derived Extracellular Vesicles in the Regulation of Metabolic Health and DiseaseLARK

8:30 AM - 10:00 AM OCCC, W311H 404 RESP Musculoskeletal Afferents and the Control of BreathingSTREETER, FULLER

8:30 AM - 10:00 AM OCCC, W308CD 405 PHYSOC/APS Physiology of Obesity: From Mechanisms to Medicine ALDISS, LEWIS

8:30 AM - 10:00 AM OCCC, W309AB 406 CVSProtein Degradation Mechanisms: A Compartmentalized Affair in Cardiac Muscle and Disease?SHEIKH, LIANG

8:30 AM - 10:00 AM OCCC, W311G 407 RENAL Advances in Renal Physiology IILAYTON, SULLIVAN

8:30 AM - 10:00 AM OCCC, W311B 408 NCAR Autonomic Function in Normal and Preeclamptic PregnanciesSTACHENFELD, USSELMAN

8:30 AM - 10:00 AM OCCC, W311C 409 CVS Cardiovascular Metabolism in DiabetesHILL, HARMANCEY

8:30 AM - 10:00 AM OCCC, W311D 410 EEP Examining Physiological Mechanisms Using Environmental StressorsJOHNSON, SCHLADER

8:30 AM - 10:00 AM OCCC, W311A 411 CELL Ion Channels, Solute and Molecular Transporters In Heath and DiseaseBAINES, ALTHAUS

8:30 AM - 10:00 AM OCCC, W312A 412 GIL John Forte Plenary SessionFREY

8:30 AM - 10:00 AM OCCC, W314 413APS-ASPET Presidential Symposia Series: Microbiome. Microbiota in Action: The Gut and BeyondMCCABE, CUI

20 | ANNUAL MEETING



8:30 AM - 10:00 AM OCCC, W312B 414 RESPInflammasome Activation in Diseases of the LungWATERS, YELIGAR

1:00 PM - 2:00 PM Hyatt, Plaza Intl Ballroom F 415 HISTHistory of Physiology LectureBASSINGTHWAIGHTE

1:30 PM - 2:30 PM OCCC, W308CD 416 RESPJulius H. Comroe, Jr. Distinguished Lectureship of the APS Respiration SectionMATALON

1:30 PM - 3:00 PM OCCC, W311A 417 CELLEmerging Roles of the Cytoskeleton in Striated MuscleHAWKE, PERRY

1:30 PM - 3:00 PM OCCC, W308AB 418 CVSAmerican Journal of Physiology - Heart and Circulatory Physiology Editors SymposiumZUCKER, DELEON PENNELL

1:30 PM - 3:00 PM OCCC, W312B 419 CEPSCauses and Consequences of Inter-Individual Physiological VariationREES

1:30 PM - 3:00 PM OCCC, W314 420 ILSI-NAMoving the Needle on Hypertension: What Knowledge is Needed?FUKAGAWA, WYNNE

1:30 PM - 3:00 PM OCCC, W311EF 421 EBSSMetabolism, Organ Crosstalk, Microbiome and MechanismsSUN

1:30 PM - 3:00 PM OCCC, W311G 422 RENALMighty Concepts in Mitochondrial Biology in the KidneyMALLIPATTU, LI

1:30 PM - 3:00 PM OCCC, W309AB 423 GILControl of Cellular Organelle Function, Metabolism and Injury in Fatty Liver Diseases LI, YANG

1:30 PM - 3:00 PM OCCC, W311B 424 WEHHormones and Receptors in Homeostatic Control of Physiology and during Allostasis in PathophysiologyGROBE, BALAPATTABI

1:30 PM - 3:00 PM OCCC, W311C 425 CNSNew Advances in CNS PhysiologyZARATE

1:30 PM - 3:00 PM OCCC, W311H 426 EMNoncoding RNAs: Emerging Functions in Metabolism and DiseasesHUANG, ZHANG

1:30 PM - 3:00 PM OCCC, W311D 427 NCARRegulation of Muscle Sympathetic Outflow during ExerciseFLORAS, MILLAR

1:30 PM - 3:00 PM OCCC, W312A 428 HYPOXHot Topics in HypoxiaNICHOLS

PROGRAM 2019 | 21



8:30 AM - 10:00 AM OCCC, W312B 414 RESPInflammasome Activation in Diseases of the LungWATERS, YELIGAR

1:00 PM - 2:00 PM Hyatt, Plaza Intl Ballroom F 415 HISTHistory of Physiology LectureBASSINGTHWAIGHTE

1:30 PM - 2:30 PM OCCC, W308CD 416 RESPJulius H. Comroe, Jr. Distinguished Lectureship of the APS Respiration SectionMATALON

1:30 PM - 3:00 PM OCCC, W311A 417 CELLEmerging Roles of the Cytoskeleton in Striated MuscleHAWKE, PERRY

1:30 PM - 3:00 PM OCCC, W308AB 418 CVSAmerican Journal of Physiology - Heart and Circulatory Physiology Editors SymposiumZUCKER, DELEON PENNELL

1:30 PM - 3:00 PM OCCC, W312B 419 CEPSCauses and Consequences of Inter-Individual Physiological VariationREES

1:30 PM - 3:00 PM OCCC, W314 420 ILSI-NAMoving the Needle on Hypertension: What Knowledge is Needed?FUKAGAWA, WYNNE

1:30 PM - 3:00 PM OCCC, W311EF 421 EBSSMetabolism, Organ Crosstalk, Microbiome and MechanismsSUN

1:30 PM - 3:00 PM OCCC, W311G 422 RENALMighty Concepts in Mitochondrial Biology in the KidneyMALLIPATTU, LI

1:30 PM - 3:00 PM OCCC, W309AB 423 GILControl of Cellular Organelle Function, Metabolism and Injury in Fatty Liver Diseases LI, YANG

1:30 PM - 3:00 PM OCCC, W311B 424 WEHHormones and Receptors in Homeostatic Control of Physiology and during Allostasis in PathophysiologyGROBE, BALAPATTABI

1:30 PM - 3:00 PM OCCC, W311C 425 CNSNew Advances in CNS PhysiologyZARATE

1:30 PM - 3:00 PM OCCC, W311H 426 EMNoncoding RNAs: Emerging Functions in Metabolism and DiseasesHUANG, ZHANG

1:30 PM - 3:00 PM OCCC, W311D 427 NCARRegulation of Muscle Sympathetic Outflow during ExerciseFLORAS, MILLAR

1:30 PM - 3:00 PM OCCC, W312A 428 HYPOXHot Topics in HypoxiaNICHOLS

22 | ANNUAL MEETING



3:30 PM - 5:00 PM OCCC, W311B 429 PHYSOCThe Clinical and Metabolic Benefits of Exercise for People with Type 1 DiabetesWAGENMAKERS, NARENDRAN

3:30 PM - 5:00 PM OCCC, W311H 430 WEHEffect of Diet on Metabolism, Cardiovascular and Renal Physiology and PathophysiologyDRUMMOND, PATI

3:30 PM - 5:00 PM OCCC, W311C 431 ETGHebert Lecture of the Epithelial Transport GroupMCDONOUGH, KAZI

3:30 PM - 5:00 PM OCCC, W312B 432 CVSInflammation and Leukocyte Biology in Cardiovascular DiseaseHALADE, DE CASTRO BRAS

3:30 PM - 5:00 PM OCCC, W311A 433 EMEndocrinology and Metabolism Section Trainee and Early Career Awardees SessionROMERO, SIDOSSIS

3:30 PM - 5:00 PM OCCC, W311D 434 NCAR/CNSHot Topics in NeuroscienceBANEK, WAINFORD

3:30 PM - 5:00 PM OCCC, W311G 435 NPIGHot Topics in NutritionTHALACKER-MERCER, BORSHEIM

5:15 PM - 5:40 PM OCCC, W314 436 APS Trainee Awards Recognition

5:40 PM - 6:30 PM OCCC, W314 437 APS Nobel Prize Award LectureAGRE

PROGRAM 2019 | 23



3:30 PM - 5:00 PM OCCC, W311B 429 PHYSOCThe Clinical and Metabolic Benefits of Exercise for People with Type 1 DiabetesWAGENMAKERS, NARENDRAN

3:30 PM - 5:00 PM OCCC, W311H 430 WEHEffect of Diet on Metabolism, Cardiovascular and Renal Physiology and PathophysiologyDRUMMOND, PATI

3:30 PM - 5:00 PM OCCC, W311C 431 ETGHebert Lecture of the Epithelial Transport GroupMCDONOUGH, KAZI

3:30 PM - 5:00 PM OCCC, W312B 432 CVSInflammation and Leukocyte Biology in Cardiovascular DiseaseHALADE, DE CASTRO BRAS

3:30 PM - 5:00 PM OCCC, W311A 433 EMEndocrinology and Metabolism Section Trainee and Early Career Awardees SessionROMERO, SIDOSSIS

3:30 PM - 5:00 PM OCCC, W311D 434 NCAR/CNSHot Topics in NeuroscienceBANEK, WAINFORD

3:30 PM - 5:00 PM OCCC, W311G 435 NPIGHot Topics in NutritionTHALACKER-MERCER, BORSHEIM

5:15 PM - 5:40 PM OCCC, W314 436 APS Trainee Awards Recognition

5:40 PM - 6:30 PM OCCC, W314 437 APS Nobel Prize Award LectureAGRE

24 | ANNUAL MEETING

ORAL SESSIONSSATURDAY, APRIL 6

50 Beyond the Weight Room: The Importance of Skeletal Muscle in Health and Disease

Symposium SAT 8:00 a.m.-12:00 p.m., Convention Center, W314

Sponsored By: Education Committee • CoSponsor: J . Appl . Physiol . Supported By: APS Strategic Partner ADInstruments Chair: E. Merritt · Co-Chair: J. Durocher Track: Education, Career Central

8:00 Teaching the Etiology of Metabolic Disease from a Mitochondrial Bioenergetics Perspective, Darrell Neufer, East Carolina University

9:00 Skeletal Muscle Metabolism in the ICU, Craig Porter, Shriners Hospital for Children

10:00 Active Learning of Skeletal Muscle, Steve Elmer, Michigan Tech University

11:00 Age-Related Changes in Skeletal Muscle: Differences between Females and Males, Anna Thalacker-Mercer, Cornell University

51 ETG Pre EB Meeting

Conference SAT 9:00 a.m.-5:00 p.m., Hyatt, Plaza Intl Ballroom H

Sponsored By: Epithelial Transport Group

52 MCS President’s Symposium: Clinical Perspectives on the Microcirculation

Symposium SAT 9:30 a.m.-11:30 a.m., Convention Center, W315

Sponsored By: Microcirculatory Society (MCS) Chair: S. Pierce-Cottler · Co-Chair: A. Mendelson

9:30 Why the Microcirculation Matters in Critical Illness, Fong Lam, Baylor College of Medicine

10:00 The Cognitive Consequences of Systemic Microcirculatory Injury in Sepsis, Eric Schmidt, University of Colorado - Denver

10:30 Human Adipose Derived Stems Cells and Therapy, Adam Katz, University of Florida

11:00 Microcirculatory Failure as a Common Mechanism of Injury after Stroke-Clinical Insights from Subarachnoid Hemorrhage and Large Vessel Occlusion, Yashar Kalani, University of Virginia

PROGRAM 2019 | 25

53 MCS Mentoring Lunch

Society Event SAT 12:00 p.m.-1:00 p.m., Convention Center, W308AB

Sponsored By: Microcirculatory Society (MCS)

54 APS-ASPET Presidential Symposia Series: Microbiome. Workshop on Microbiome Research: What You Need to Know

Workshop SAT 1:00 p.m.-3:00 p.m., Convention Center, W311EF

Sponsored By: President’s Symposium Series Chair: A. D. Patterson · Co-Chair: M. Hullar Track: Microbiome

1:00 Experimental Design for Mouse Studies, Cathryn Nagler, The University of Chicago

1:30 Experimental Design for Human Studies, Meredith Hullar, U . Washington

2:00 Bioinformatics: Sequencing and Metagenomics, Mehrbod Estaki, University of British Columbia

2:30 Defining the Chemical Complexity of the Microbiome through Metabolomics, Andrew Patterson, Penn State University

55 Alzheimer’s Disease: Many Failed Trials so Where Do We Go from Here?

Symposium SAT 1:00 p.m.-2:30 p.m., Convention Center, W308CD

Sponsored By: American Federation for Medical Research (AFMR) Chair: A. Reiss · Co-Chair: M. Stecker Track: Neuroscience

1:00 Turning Failure into Success: What We Can Learn from the Drugs that Did Not Show Benefit, Mark Stecker, UCSF Fresno

1:30 Pathophysiology of Alzheimer’s Disease: From Bench to Bedside, Allison Reiss, NYU Winthrop Hospital

2:30 Biomarkers for Alzheimer’s Disease: Prediction to Prevent Progression, Benjamin Wolozon, Boston University School of Medicine

26 | ANNUAL MEETING


56 A Role for Professional Societies in Addressing and Preventing Sexual Harassment in the Sciences

Symposium SAT 1:00 p.m.-3:00 p.m., Convention Center, W309AB

Sponsored By: Science Policy Committee • CoSponsored by: Women in Physiology Committee Supported By: Committee Chair: S. Goulopoulou · Co-Chair: C. Wilson Track: Career Central, Public Engagement / Science Policy

1:00 Sexual Harassment of Women: Climate, Culture and Consequences in Academic Sciences, Engineering and Medicine, Gilda Barabino, City College of New York

2:00 Stepping up to the Responsibility: Scientific Societies’ Role and Progress in Addressing Harassment in Science, Billy Williams, American Geophysical Union

2:30 Disobedience, Laws and Money: The Teeth the NASEM Report Needs to Work, BethAnn McLaughlin, Vanderbilt University Medical Center

57 Microcirculation’s Contribution to Organ Failure

Symposium SAT 1:00 p.m.-3:00 p.m., Convention Center, W315

Sponsored By: Microcirculatory Society (MCS) Chair: A. Beyer · Co-Chair: C. Halabi

1:00 The Role of Coronary Micricirculation in Development of Cardiomyopathies, Vahagn Ohanyan, Northeast Ohio Medical University

1:20 The adenosine kinase inhibitor ABT-702 improves coronary vasodilator and left ventricle diastolic dysfunction in obese ZSF1 rats, A. Davila, Y. Tian, I. Czikora, Z. Bagi, Augusta University

1:32 Therapeutic Use of Telomerase for Cardioprotection, Christiane Baer, University of Hannover

1:44 Integrative Effects of Autophagy and Telomerase on Arteriolar Flow-Mediated Dilation in Health and Coronary Artery Disease, W.E. Hughes, A.M. Beyer, D.D. Gutterman, Medical College of Wisconsin

1:54 Hydrogen Sulfide is Not Like NO in the Microcirculation, Nancy Kanagy, University of New Mexico

PROGRAM 2019 | 27

2:06 Age-related Peripheral Vascular Dysfunction Predicts Cognitive Decline in Healthy Individuals, T. Csipo, G.A. Fulop, A. Lipecz, S. Tarantini, R. Hand, B-T. Ngo, M. Dzialendzik, P. Balasubramanian, T. Kiss, V. Yabluchanska, A. Csiszar, Z. Ungvari, A. Yabluchanskiy, University of Oklahoma Health Science Center

2:18 Peroxynitrite Impairs Caveolin-1-TRPV4 Channel Signaling in Pulmonary Hypertension, C. Marziano, K. Hong, E.L. Cope, M. Ottolini, S.K. Sonkusare, University of Virginia

2:30 Childhood Sirt1 Is a Predictor of Microvascular Function in Adulthood, P. Rodriguez Miguelez, J. Thomas, J. Looney, G. Harshfield, J.S. Pollock, R. Harris, Augusta University and University of Alabama at Birmingham

58 6th Annual PG Conference

Conference SAT 1:00 p.m.-5:00 p.m., Convention Center, W311H

Sponsored By: Physiological Omics Group

59 Water and Electrolyte Trainee Award Finalists and Data Diuresis

Award Session SAT 2:00 p.m.-5:00 p.m., Hyatt, Plaza Intl Ballroom G

Sponsored By: Water and Electrolyte Homeostasis Section Supported by: Portland Press and Jual Carlos Romero Fund Chair: T. Cunningham · Co-Chair: A. Loria, M. Hulstrom

Predoctoral Award Finalists Presentations (Sponsored by Portland Press)

2:00 Bioengineered VEGF Therapy Following Angioplasty in Renovascular Disease: More and Better Microvessels, E. Guise, J. Engel, M. Williams, G.L. Bidwell, A. Chade, University of Mississippi Medical Center

2:15 African Green Monkeys Born to Mothers with Hypertensive Pregnancy Disorders have Higher Blood Pressures and Altered Water Balance in Early Adolescence, C.C. Weaver, J.L. Osborn, University of Kentucky and Primates Plus

2:30 Intrapartum Sildenafil Therapy Reprograms Susceptibility to Hypertension in Offspring of Dahl S Rats, H.R. Turbeville, A. Desai, M.R. Garrett, J.M. Sasser, University of Mississippi Medical Center

28 | ANNUAL MEETING


Postdoctoral Award Finalists Presentations (Sponsored by Juan Carlos Romero Fund)

2:45 Soluble Guanylate Cyclase Activators Increase cGMP Expression and Improve Vascular Function and Placental Ischemia-Induced Hypertension, B.A. Bakrania, F.T. Spradley, B.R. Patel, A.B. Travis, P. Sandner, J.P. Granger, University of Mississippi Medical Center and Bayer AG, Germany

3:00 Elevated Saturated Fatty Acids Attenuate Trophoblast Migration Via TLR Signaling Mechanisms, J.L. Bradshaw, L.B. Strong, J.P. Granger, University of Mississippi Medical Center

3:15 Withdrawn

3:30 Mingle with Open Bar

Data Diuresis Brief Presentations, Chaired by Michael Hulsstrom

4:15 Long-term consequences of severe food restriction on the heart of female Fischer rats, A.M. A. de Souza, C. West, H. Ji, N.V. Shults, Y.J. Suzuki, K. Sandberg, Georgetown University

4:20 High Sodium Diet in 11β Hydroxysteroid Dehydrogenase Type 2 CNS Knockout Mice Induces a Proinflammatory Phenotype of Perivascular Adipose Tissue and Alterations in Arterial Reactivity, C. Grenier, A. Ralph, D.E. Livingstone, M.C. Holmes, M.A. Bailey, Centre for Cardiovascular Science, United Kingdom

4:25 Liposome Delivery Enhances Clodronate Nephrotoxicity in Dahl SS Hypertension and Renal Injury, D.J. Fehrenbach, J.M. Abais-Battad, H. Lund, J. H. Dasinger, D.L. Mattson, Medical College of Wisconsin

4:30 Chronic high fat diet lowers male detrusor mitochondrial fatty acid oxidation while females are protected, H.L. Kosnik, K. Fisher-Wellman, M.R. Odom, E.S. Pak, J.L. Hannan, East Carolina University, BSOM and East Carolina University

4:35 Differential DNA Methylation Between African Americans And European Americans: the Role of Childhood Socioeconomic Status and Relations to Health Disparity, Y. Pan, X. Wang, F. Treiber, G. Harshfield, S. Su, Augusta University and Medical University of South Carolina

4:40 Increased vasopressin secretion during preeclampsia despite normal plasma osmolality, S. Y. Zhang, A.T. Ray, E. Lewis, G. Deng, J.A. Sandgren, S.M. Scroggins, J. Xue, N.A. Pearson, D. Zepeda-Orozco, C.D. Sigmund, M.K. Santillan, G.L. Pierce, D.A. Santillan, J.L. Grobe, University of Iowa

4:45 Mingle with Open Bar

PROGRAM 2019 | 29

60 New Method and Models to Study Human Metabolism with Stable Isotope Tracers

Symposium SAT 3:00 p.m.-4:30 p.m., Convention Center, W308CD

Sponsored By: American Federation for Medical Research (AFMR) Chair: M. Cree-Green · Co-Chair: E. Parks

3:00 Advances in Isotope Models for Understanding Protein Metabolism, Robert Wolfe, University of Arkansas Medical School

3:30 Use of an Oral Glycerol Drink Combined with Isotopomer Analysis to Understand Hepatic Metabolism, Craig Malloy, UT Southwestern Medical Center

4:00 Adapting Oral Glucose Tolerance Tests with Tracers to Different Patient Populations, Cecelia Diniz-Behn, Colorado School of the Mines

61 Data NCARnation

Award Session SAT 3:00 p.m.-5:00 p.m., Convention Center, W311G

Sponsored By: Neural Control and Autonomic Regulation Section Supported by: Data Sciences International, Inc . Chair: A. J. Miller · Co-Chair: K. Blackmore

3:00 Sympathetic Discharge Patterns and Neurovascular Transduction Following Acute Intermittent Hypoxia, D.W. Jacob, S.E. Baker, Z.E. Scruggs, E.P. Ott, J.L. Harper, C.L. Manrique, J.K. Shoemaker, J.K. Limberg, University of Missouri, Mayo Clinic and University of Western Ontario, Canada

3:05 Selective Reductions in Pulmonary Artery Pressure Lowers Sympathetic Neural Activity in Healthy Humans at High Altitude, L.L. Simpson, A. Steele, V.L. Meah, S. Thapamagar, C. Gasho, A. Drane, S.J. Oliver, M.M. Tymko, P.N. Ainslie, C.D. Steinback, M. Stembridge, J.P. Moore, Bangor University, United Kingdom, University of Alberta, Canada, Loma Linda University, Cardiff Metropolitan University, United Kingdom and University of British Columbia, Canada

3:10 Angiotensin II-Mediated AT1R-TLR4 Crosstalk Promotes Blood-Brain Barrier Disruption, Microglial Activation and Sympathoexcitation in Hypertension, F.E. Mowry, M.C. Silva-Cutini, S.C. Peaden, V.C. Biancardi, Auburn University

3:15 Discussion

30 | ANNUAL MEETING


3:20 A Projection from the Hypothalamic Paraventricular Nucleus (PVN) to Nucleus Tractus Solitarii (NTS) is Essential for Cardiorespiratory responses to hypoxia, B. Ruyle, C. Trogstad-Isaacson, S. Friskey, D. Kline, C. Heesch, E. Hasser, University of Missouri and Dalton Cardiovasc Research Center

3:25 Renal Sensory Nerves Increase Blood Pressure and Sympathetic Nerve Activity in 2-Kidney 1-Clip Hypertensive Mice, J. Ong, A.F. Sved, B.J. Kinsman, R.J. Tan, B.M. Rush, M.D. Carattino, S.D. Stocker, University of Pittsburgh

3:30 Angiotensin Type 1 Receptor (AT1R) Inhibition Disrupts Reconsolidation of Conditioned Auditory Fear, A.P. Swiercz, Z. Yu, A. Edwards, P.J. Marvar, George Washington University

3:35 Discussion

3:40 Sympathomodulation in Heart Failure: A Role for Stellate Ganglia NRF2, J. Shanks, L. Gao, I.H. Zucker, University of Nebraska Medical Center

3:45 Metabo and Mechanoreceptor Expression in Heart Failure Patients: Relationships with Neural and Cardiovascular Responses to Exercise, J.R. Smith, C.R. Hart, P.A. Ramos, J.G. Akinsanya, I.R. Lanza, T.P. Olson, Mayo Clinic

3:50 A Novel Rat Model of Sleep Apnea Reveals Increased Sensitivity to Opioid-Induced Respiratory Depression and an Unexpected Role for Endogenous Opioids, A.D. Brackley, M. A. Andrade, G.M. Toney, The University of Texas Health Science Center at San Antonio

3:55 Discussion

4:00 Involvement of Phox2B Neurons Located in the Commissural NTs with the Maintenance of Hypertension in SH Rats, M. Del Rosso de Melo, S.J. Ong, A.A. Connelly, J.K. Bassi, E. Colombari, A.M. Allen, The University of Melbourne, Australia, UNESP, Brazil, Florey Institute of Neuroscience and Mental Health and University of Melbourne, Australia

4:05 Effects of β2 Adrenergic Receptor on Coronary Blood Flow and Cardiovascular Responses during Exercise and Metaboreflex in Men and Women, E. Prodel, T. Cavalcanti, H. Miguens, C. Assumpção, P. Mira, A.C. Nobrega, Fluminense Federal University, Brazila

4:10 Intraluminal Nutrients Modulate Intracellular Calcium Activity in the Enteric Nervous System of Adult Mice, J-B. Cavin, J. Glover, W.K. MacNaughton, K.A. Sharkey, Physiology and Pharmacology, University of Calgary, Canada, Snyder Institute for Chronic Diseases, University of Calgary, Canada, Hotchkiss Brain Institute, University of Calgary, Canada, Live Cell imaging Laboratory and University of Calgary, Canada

4:15 Discussion

PROGRAM 2019 | 31

62 Writing Good Multiple Choice Questions: A Hands-On Workshop

Workshop SAT, 3:15 p.m.-5:15 p.m., Convention Center, W311EF

Sponsored By: Techniques Workshop Program • Co Sponsored by: Advances in Physiology Education and American Association of Anatomists Chair: D. V. Silverthorn

3:15 Good Question-Writing Techniques, Christine Kauffman, University of Central Florida

4:15 Writing MCQs Using the National Board of Medical Examiner Guidelines, Andrew Thompson, University of Cincinnati College of Medicine

63 Emerging Topics: Adaptation of Microvessels and Lymphatics

Symposium SAT, 3:30 p.m.-5:30 p.m., Convention Center, W315

Sponsored By: Microcirculatory Society (MCS) Chair: J. Breslin · Co-Chair: F. Mac Gabhann

3:30 Endothelial Calcium Signaling in the Microcirculation in Vascular Disorders, Swapnil Sonkusar, University of Virginia

3:45 TRP Channels and Vascular Control, Scott Earley, University of Nevada, Reno

4:00 Electrical Signaling in the Cerebral Microcirculation: Insights from Mathematical Models, Mikoloas Tsoukias, Florida International University

4:15 Activation of ANO1 by SR Ca2+ Release Underlies the Pressure Dependent Pacemaking of Murine Lymphatic Collecting Vessels, Scott Zawieja, University of Missouri

4:30 The Blood-Brain Barrier and Its Modulation by Trans-Cranial Current Stimulation, Bingmei Fu, City College of New York

4:45 Cerebral Parenchymal Arteriolar Dilation and Cognitive Function in Hypertension, Anne Dorrance, Michigan State University

5:00 Therapeutic Vascularization for Tissue Regeneration, Sara Nunes de Vasconcelos, University of Toronto

5:15 Gonadal Hormone Loss and Obesity-Induced Lymphatic Leakage: Epigenetic Mechanisms, Flavia Souza-Smith, LSU Health Science Center, New Orleans

32 | ANNUAL MEETING


64 Building the Future of APS (and Physiology)

Lecture SAT, 5:30 p.m.-6:30 p.m., Convention Center, W314

Sponsored By: APS

5:30 Building the Future of APS (and Physiology), Scott Steen, American Physiological Society

65 Tang Prize Award

Lecture SAT, 6:00 p.m.-7:00 p.m., Convention Center, Chapin Theater

Sponsored By: Tang Foundation

6:00 Imatinib as a Paradigm of Targeted Cancer Therapies, Brian Druker, Oregon Health & Science University

66 MCS Poster Discussion and Reception

Society Event SAT, 6:00 p.m.-8:00 p.m., Convention Center, W308AB


Chair: A. LeBlanc

PROGRAM 2019 | 33

147 Career Planning: No Scientist Left Behind (Sunday)

Symposium SUN, 7:00 a.m.-8:00 a.m., Convention Center, W311C

Sponsored By: Women in Physiology Committee Chair: N. Nicols · Co-Chair: S. Randive, M. Porta Track: Career Central

7:00 Juggling a Career and Parenthood: A Scientist’s Perspective, Jacqueline Limberg, University of Missouri

148 Marketing Yourself for a Successful Career I

Symposium SUN, 7:00 a.m.-8:00 a.m., Convention Center, W311B

Sponsored By: Trainee Advisory Committee Chair: I. Obi · Co-Chair: M. Zarate Track: Career Central

7:00 How to Build Marketable Skills, Merry Lindsey, University of Nebraska Medical Center

149 The Hidden Job: Skills for a Career in Physiology

Symposium SUN, 7:00 a.m.-8:00 a.m., Convention Center, W311D

Sponsored By: Careers in Physiology Committee Chair: B. Becker · Co-Chair: C. Trimby Track: Career Central

7:00 Tools for Transitions, David Brooks, Janssen Pharmaceuticals

7:30 Tools for Transitions, Kathy Ryan, US Army Inst . of Surgical Res .

ORAL SESSIONSSUNDAY, APRIL 7

34 | ANNUAL MEETING

150 Publishing 101

Workshop SUN, 8:30 a.m.-10:00 a.m., Convention Center, W309AB

Sponsored By: Publications Committee • CoSponsor: Advances in Physiology Education and AJP - Lung Cellular and Molecular Physiology . Chair: C. D. Sigmund · Co-Chair: R. S. Scheman Track: Career Central

8:30 Preparing Your Work for Publication in APS Journals, Curt Sigmund, Medical College of Wisconsin

9:00 Publications Ethics Considerations, Christina Bennett, American Physiological Society

9:30 Editor Update and Case Study Panelist, Kim Barrett, University of California, San Diego

9:30 Editor Update and Case Study Panelist, Thomas Kleyman, University of Pittsburgh

151 Aquaporins: More than Water under the Bridge

Symposium SUN, 8:30 a.m.-10:00 a.m., Convention Center, W311EF

Sponsored By: Experimental Biology Symposium Series • CoSponsor: AJP - Cell Physiology and AJP - Renal Physiology Chair: M. Mamenko · Co-Chair: D. Ilatovskaya

8:30 Aquaporin-3 in the Epidermis: More than Skin Deep, Wendy Bollag, Augusta University

9:00 Aquaporin 2 and Water Balance: An Ever Evolving Story, Hanne Moeller, Aarhus University

9:30 The Role of Aquaporins and Glycerol Metabolism in Male Fertility, Pedro Oliveira, University of Porto


PROGRAM 2019 | 35

152 Central Control of Breathing: Gliocentric Mechanisms

Symposium SUN, 8:30 a.m.-10:00 a.m., Convention Center, W308CD

Sponsored By: Respiration Section • CoSponsored by: AJP - Lung Cellular and Molecular Physiology Chair: G. D. Funk · Co-Chair: D. Mulkey Track: Cell Signaling, Signal Transduction, Neuroscience, Ion Channels and Transporters

8:30 Central Mechanisms, Glial and Purinergic, Shape the Hypoxic Ventilatory Response, Greg Funk, University of Alberta

8:50 Update on the Roles of Astrocytes and Purinergic Signaling in the Regulation of Ventral Surface Chemoreceptors, Daniel Mulkey, University of Connecticut

9:10 Astrocytes Regulate Brainstem Respiratory Rhythm-Generating Circuits, Shahriar Sheikhbahaei, NINDS

9:30 Unraveling Neuroglial Interactions Underlying the Central Hypoxic Response and Sigh Generation in the preBötzinger Complex, Liza Severs, University of Washington

153 Exercise and Heat Therapy: Shared Molecular Targets and Cardiometabolic Benefits

Symposium SUN, 8:30 a.m.-10:00 a.m., Convention Center, W311C

Sponsored By: Environmental and Exercise Physiology Section • CoSponsored by: J . Appl . Physiol . Chair: C. T. Minson Track: Muscle Metabolism, Inflammation/Immunity, Metabolic Programming/Epigenetics

8:30 Exercise and Heat Therapy: Shared Molecular Targets and Metabolic Adaptations, Paige Geiger, University of Kansas Medical Center

8:50 Targeting Heat Shock Proteins in the Prevention of Metabolic Disease, Mark Febbraio, Garvan Institute of Medical Research

9:10 Heat Therapy and Inflammation in Obesity: Impacts on Cardiometabolic Health, Brett Ely, Salem State University

9:30 Cardiometabolic Roles for Heat Shock Proteins Following Heat Stress End Exercise, Steve Faulkner, Nottingham Trent University

36 | ANNUAL MEETING


154 Neurodegeneration and Heart Failure: An Intimate Connection

Symposium SUN, 8:30 a.m.-10:00 a.m., Convention Center, W311H

Sponsored By: Cardiovascular Section • CoSponsor: AJP - Heart and Circulatory Physiology Chair: F. del Monte · Co-Chair: L. E. Wold

8:30 Common Presenilin Genetics in AD and HF, Cristina Balla, University of Ferrara

8:50 Brain and Cardiac Tauopathy and Aging, Onder Albayram, Beth Israel Deaconess Medical Center

9:10 Methabolic Dysfunction in AD and HF, Monte Willis, University of North Carolina, Chapel Hill

9:30 Diabetic Cardiomyopathy and AD: An Amylin Substrate, Florin Despa, University of Kentucky

155 Translational Models of Renal and Cardiovascular Disease: Informing Human Health or Not?

Symposium SUN, 8:30 a.m.-10:00 a.m., Convention Center, W311D

Sponsored By: Water and Electrolyte Homeostasis Section Chair: L. M. Harrison-Bernard Co-Chair: J. L. Osborn Track: Ion Channels and Transporters, Nutrition/Diet, Metabolic Programming/Epigenetics

8:30 Renal and Cardiovascular Disease in the Nonhuman Primate, Jeffrey Osborn, University of Kentucky

9:00 Swine Models of Cardiovascular Disease, David Lefer, Louisiana State University

9:30 Nonsalt-Sensitive Mendelian Hypertension Translates into Novel Animal Models, Frederick Luft, Max Delbrück Center for Molecular Medicine

PROGRAM 2019 | 37

156 Cardiac ECM Niche in Health and Disease

Featured Topic SUN, 8:30 a.m.-10:00 a.m., Convention Center, W311G

Sponsored By: Cardiovascular Section • Cosponsored by: AJP - Heart and Circulatory Physiology Chair: I. Dixon · Co-Chair: L. G. Griffiths

8:30 The Cardiac Extracellular Matrix Niche Directs Cell Growth and Behavior, Leigh Griffiths, Mayo Clinic

9:00 Extracellular Matrix Components Isolated from Diabetic Mice Alters Cardiac Fibroblast Function through the AGE/RAGE Signaling Cascade, S. Burr, J.A. Stewart; Jr., The University of Mississippi

9:15 Myocardial Infarction-Relevant MMP-12 Interactions Identified by Correlation Analysis O. Rivera Gonzalez, M.L. Lindsey, University of Mississippi Medical Center

9:30 Supplementation with the Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening in Young Mice, A.G. Casso, R.A. Gioscia-Ryan, Z.J. Sapinsley, J.J. Richey, M.C. Zigler, N.S. VanDongen, C.J. Angiletta, L.E. Griffin, A.P. Neilson, D.R. Seals, V.E. Brunt, University of Colorado Boulder and Virginia Polytechnic Institute and State University

9:45 Right Ventricular Hypertrophy is Associated with Increased MAPK8, Fibronectin and Extracellular Matrix Regulatory Biomarker (MMP/TIMP) mRNA Levels in a Pre-Clinical Swine Model of HFpEF, S.C. Kelly, C. Rau, P.K. Thorne, J.C. Edwards, T.D. Olver, T.L. Domeier, J. Padilla, Y. Wang, R.S. Rector, C.A. Emter, University of Missouri, Columbia, University of California, Los Angeles and Harry S . Truman Memorial Veteran’s Hospital

157 Innovative Techniques for Teaching Health Sciences to Increase Retention and Mastery Learning

Featured Topic SUN, 8:30 a.m.-10:00 a.m., Convention Center, W312B

Sponsored By: Teaching of Physiology Section • CoSponsored By: Advances in Physiology Education Chair: H. M. Jones · Co-Chair: S. K. ElSayed Track: Education

8:30 Using innovative technologies to increase student engagement in an online Anatomy and Physiology course, H.M. Jones, Lake Erie College of Osteopathic Medicine

38 | ANNUAL MEETING


8:45 Why Is It So Hard to Lose Fat? Because It Has to Get Out through Your Nose! A Lab Based Activity on Oxygen Consumption, Metabolic Equations and the Futility of Exercise-Only Weight Loss Plans, E.K. Merritt, Southwestern University

9:00 Using Physiology Review Videos to Improve Knowledge Retention and Clinical Reasoning Skills in Second-Year Medical Students, J.A. Dominguez Rieg, University of South Florida Morsani College of Medicine

9:15 Collaborative Exams in an Undergraduate Anatomy and Physiology Classroom Enhance Students Perceived Learning and Knowledge Retention, J.A. Stokes, Centenary College of Louisiana

9:30 The Self-Assessment Dilemma: An Open-Source, Ethical Method using Matlab to Formulate Multiple Choice Quiz Questions for Online Reinforcement, H.J. Witchel, J.H. Guppy, C.F. Smith, Brighton and Sussex Medical School, United Kingdom

9:45 Educational Game to Integrate the Physiology of Synapses, Muscle Contraction and Autonomous Nervous System: Effects on Learning and Perception of Dental Students, F.K. Marcondes, A.P. Castro, L.T. Cardozo, F.C. Groppo, Piracicaba Dental School and University of Campinas, Brazil

158 Kaley Award Featured Topic: The Microcirculation and Its Many Cells that Contribute to Tissue Repair

Featured Topic SUN, 8:30 a.m.-10:00 a.m., Convention Center, W308AB

Sponsored By: Microcirculatory Society and Cardiovascular Section • CoSponsor: AJP - Heart and Circulatory Physiology Chair: P. Kubes

8:30 The Microcirculation and Its Many Cells that Contribute to Tissue Repair, Paul Kubes, University of Calgary

9:00 Platelets determine the onset of innate and adaptive immune cell responses Schaubaecher J, Mittmann L, Uhl B, Reichel CA, J. Schaubächer, Walter-Brendel-Zentrum, Germany

9:15 Macrophage Insulin-Like Growth Factor 1 Downregulated Matrix Metalloproteinases and Promoted Features of a Stable Atherosclerotic Plaque, P. Snarski, S. Danchuk, S. Sukhanov, T. Yoshida, Y. Higashi, S. Y. Shai, B. Chandrasekar, P. Delafontaine, University of Missouri, Tulane University and Harry S . Truman Memorial Veterans’ Hospital

9:30 Role of Red Blood Cell Released ATP in Disturbed Blood Flow-Initiated Vascular Inflammation and Atherosclerosis, Y. Zhang, S. Huang, K.B. LaPenna, P. He, College of Medicine and Pennsylvania State University

PROGRAM 2019 | 39

9:45 Macrophage Depletion Reverses Impaired Sympathetic Vasoconstriction and Sensory Vasodilation of Mesenteric Arteries from IL-10-/- Mice with Inflammatory Bowel Disease, E.L. Grunz-Borgmann, B.W. Jones, E.M. Boerman, University of Missouri

159 NCAR Young Investigator Awards Featured Topic

Featured Topic SUN, 8:30 a.m.-10:00 a.m., Convention Center, W311B

Sponsored By: Neural Control and Autonomic Regulation Section Chair: L-J. Xu · Co-Chair: R. Del Rio

8:30 Angiotensin-(1-7) Attenuates Blood Pressure and Cardiac Hypertrophy in Aged Mice, A.J. Miller, S.S. Bingaman, M. White, A.C. Arnold, Pennsylvania State University College of Medicine

8:45 Estrous Cycle Modulates inhibition of Dorsal Vagal Motor Neurons, C.R. Boychuk, E. Littlejohn, L. Espinoza, UT Health San Antonio

9:00 GABAA Receptors Modulate Muscle Sympathetic Nerve Activity and Pressor

Responses to Skeletal Muscle Metaboreflex Activation in Humans, A.L. Teixeira, I.A. Fernandes, L.C. Vianna, University of Brasília, Brazil

9:15 Arterial Baroreflex Control of Multi- and Single-Unit Muscle Sympathetic Nerve Activity in Young Unmedicated Hypertensives, A.V. Incognito, M. Samora, A.D. Shepherd, R.A. Cartafina, G.M. Guimarães, M. Daher, P.J. Millar, L.C. Vianna, University of Guelph, Canada and University of Brasilia, Brazil

9:30 Sensitization of the Cardiac Sympathetic Afferent Reflex Contributes to Increased Sympathetic Tone in a Mouse Model of Hypertrophic Cardiomyopathy, R.A. Larson, Y. Lu, C.J. Benson, M.W. Chapleau, University of Iowa and Veterans Affairs Medical Center

9:45 Global REACH Expedition: Chronic Hypoxia Attenuates the Contribution α-Adrenergic Receptors to Sympathetic Transduction in Exercising Humans, C.M. Hearon, A.B. Hansen, G. Moralez, S.A. Romero, B.D. Levine, J.S. Lawley, UT Southwestern Medical Center, University of Innsbruck, Austria and University of North Texas Health Science Center

10:00 Cellular Senescence in the Rostral Ventrolateral Medulla (RVLM): Novel Implications for Obesity-Induced Sympathoexcitation, M. Subramanian, A. Csiszar, Z. Ungvari, P. Balasubramanian, Oklahoma State University and University of Oklahoma Health Sciences Center

40 | ANNUAL MEETING


160 Renal Section Young Investigator Award Featured Topic: At the Nexus of Circadian Biology and Renal Physiology

Featured Topic SUN, 8:30 a.m.-10:00 a.m., Convention Center, W311A

Sponsored By: Renal Section • Cosponsored By: AJP - Renal Physiology Chair: M. Gumz · Co-Chair: C. Wingo Track: Cell Signaling, Signal Transduction

8:30 Time Flies: Recent Advances in Understanding the Kidney Clock, Michelle Gumz, University of Florida

9:00 Mechanisms of Salt-Sensitive Hypertension in a Mouse Model of ACTH-Dependent Cushing Syndrome, H.M. Costello, K. Stewart, N.K. Jones, C. Grenier, A.F. Ralph, D.E. W. Livingstone, N. Dhaun, M.A. Bailey, The University of Edinburgh, United Kingdom

9:15 The Intrinsic Circadian Clock in Podocytes Controls the Glomerular Filtration Rate, C. Ansermet, G. Centeno, S. Pradervand, M. Maillard, D. Firsov, University of Lausanne, Switzerland and Centre Hospitalier Universitaire Vaudois, Switzerland

9:30 Uncoupling of Sodium and Potassium Excretion in Kidney-Specific BMAL1 Knockout Mice following Potassium Depletion, G.R. Crislip, L.G. Douma, S.H. Masten, K-Y. Cheng, I.J. Lynch, D. Barral, K. Glasford, K.A. Esser, C.S. Wingo, M.L. Gumz, University of Florida and North Florida/South Georgia Veterans Health System

9:45 Total Spectral Power and High Frequency Blood Pressure Variability is Reduced in Male BMAL1-Collecting Duct Knock-Out Mice During the Inactive Period, M.K. Rhoads, D. Zhang, B.K. Becker, D.M. Pollock, University of Alabama at Birmingham

161 Trainee Session

Featured Topic SUN, 8:30 a.m.-10:00 a.m., Convention Center, W312A

Sponsored By: Comparative & Evolutionary Physiology Section Chair: D. A. Crossley

8:45 Characterization of Ca2+ Based Action Potentials in Horizontal Cells in the Goldfish (Carassius auratus) Retina, M.W. Country, M. Jonz, University of Ottawa, Canada

9:00 The Evolution of Air-breathing Revised, C. Damsgaard, V.B. Baliga, University of British Columbia, Canada

PROGRAM 2019 | 41

9:15 Ventricular Transcriptomic Changes Induced by Cold-Acclimation in the Painted Turtle Suggests Epigenetic-Mediated Transcriptional Remodeling, C.E. Fanter, Z. Lin, D.E. Warren, Saint Louis University

9:30 Varied Effects of Dietary Carotenoid Supplementation on Oxidative Damage in Tissues of Two Waterfowl Species, A.E. Mohr, M. Girard, M. Rowe, K.J. McGraw, K.L. Sweazea, Arizona State University and University of Oslo, Norway

9:45 Seasonal Shifts in Gut Microbiota-Mediated Nitrogen Recycling in 13-Lined Ground Squirrels, M.D. Regan, K.M. Verdoorn, E. Chiang, S.R. Gugel, F.M. Assadi-Porter, H.V. Carey, University of Wisconsin-Madison

162 APS-ASPET Presidential Symposia Series: Microbiome. Gut Microbiome and Metabolic Disorders

Symposium SUN, 8:30 a.m.-10:00 a.m., Convention Center, W314

Sponsored By: President’s Symposium Series Chair: J. M. Sands · Co-Chair: E. T. Morgan Track: Microbiome, Nutrition/Diet

8:30 Acetate Mediates a Gut Microbiome-Brain-Beta-Cell Axis: Implications for Obesity and Cancer, Rachel Perry, Yale University

9:00 Antibiotic Use and the Gut Microbiome, Martin Blaser, NYU

9:30 The Role of Diet and Small Bowel Microbiota in Health and Metabolic Diseases, Eugene Chang, University of Chicago

163 Bodil M. Schmidt-Nielsen Distinguished Mentor Award Lecture (Sponsored by Novo Nordisk Foundation)

Lecture SUN, 12:00 p.m.-1:30 p.m., Hyatt, Plaza Intl Ballroom D

12:00 Same Goals, Different Trainees; Solving for X where Goal = X . Trainee + (1-X) . Mentor, Peter Wagner, UCSD

42 | ANNUAL MEETING


164 Interaction of Cardiovascular Disease and Neuro-Cognitive Impairment

Symposium SUN, 1:30 p.m.-3:00 p.m., Convention Center, W309AB

Sponsored By: CNS Section Chair: K. Wallace · Co-Chair: S. Stocker Track: Neuroscience, Cell Signaling, Signal Transduction

1:30 Hypertension Induced Changes in the Prefrontal Cortex of the Rhesus Monkey, Tara Moore, Boston University

2:00 Hypertensive Cerebrovascular Disease and Dementia Development: A Role for Mineralocorticoid Receptor Signaling, Anne Dorrance, Michigan State University

2:30 Vascular and Neuronal Features of Cardiogenic Dementia in Swine with Experimental Heart Failure: Isolating Mechanisms Using an Integrative Approach, Dylan Olver, University of Saskatchewan

165 Metagenomic and Metabolomic Studies of Host-Microbiotal Contributions to Health and Disease


Sponsored By: Physiological Omics Group • Cosponsored By: AJP - Gastrointestinal and Liver Physiology and Physiological Reviews Chair: B. Joe · Co-Chair: J. M. Abais-Battad

1:30 Environment Trumps Genetics: Immunological and Microbiotal Studies of Metabolic Syndrome, Matam Vijay-Kumar, University of Toledo College of Medicine and Life Sciences

1:50 Microbes, Metabolomes and Diseases: Recent Insights, Andrew Patterson, Penn State University

2:10 Fiber-Mediated Nourishment of Gut Microbiota Protects Against Diet-Induced Obesity by Restoring IL-22-Mediated Colonic Health, Andrew Gewirtz, Georgia State University

2:30 Epigenetic and Metabolomic Effects of Microbiota on Hypertension, Bina Joe, University of Toledo College of Medicine and Life Sciences

PROGRAM 2019 | 43

166 SGLT2 Inhibitors: From Basic Physiology to Clinical Success

Symposium SUN, 1:30 p.m.-3:00 p.m., Convention Center, W311B

Sponsored By: Physiologists in Industry Committee • Cosponsored By: AJP - Renal Physiology Chair: R. Gonzalez Villalobos · Co-Chair: P. Pati

1:30 The Basic Physiological Mechanisms of SGLT2 Inhibition, Scott Thompson, UCSD School of Medicine

2:00 Empagliflozin and Cardiovascular Outcomes in Type 2 Diabetes, Maximilian von Eynatten, Boehringer INgelheim International GmbH

2:30 Canagliflozin and Renal Outcomes in Type 2 Diabetes, Jennifer Davidson, Janssen Pharmaceuticals

167 Survived a Complicated Pregnancy? Maternal, Postpartum and Fetal Cerebrovascular Risks

Symposium SUN, 1:30 p.m.-3:00 p.m., Convention Center, W311G

Sponsored By: Cardiovascular Section • Cosponsored By: AJP - Heart and Circulatory Physiology Chair: J. P. Warrington · Co-Chair: M. J. Cipolla

1:30 Symposium overview, Junie Warrington, UMMC

1:40 The Maternal Brain in Preeclampsia Eclampsia, Marilyn Cipolla, University of Vermont

2:00 Adverse Maternal Environment and Effects on Offspring, Sandra Davidge, University of Alberta

2:20 Postpartum Cerebrovascular Risks Following Complicated Pregnancy, George Saade, University of Texas Medical Branch

2:40 Stroke in Pregnancy and Postpartum, Cheryl Bushnell, Wake Forest School of Medicine

44 | ANNUAL MEETING


168 The Lahiri/Cherniak Lecture Symposium

Symposium SUN, 1:30 p.m.-3:00 p.m., Convention Center, W308CD

Sponsored By: Hypoxia Group Chair: C. Wilson

1:30 Carotid Body: From Physiology to Sympathetic Activation in Cardiometabolic Diseases, Rodrigo Iturriaga, Pontificia Universidad Catolica De Chile

2:00 The Role of an Olfactory Receptor in Carotid Body Oxygen Sensing, Andy Chang, UCSF

2:30 Hypoxia Signaling in Carotid Body Chemoreceptor Cells, Donghee Kim, Rosalind Franklin

169 The Role of Skeletal Muscle Damage in Adaptive Remodeling

Symposium SUN, 1:30 p.m.-3:00 p.m., Convention Center, W314

Sponsored By: Environmental and Exercise Physiology Section • Cosponsored By: J . Appl . Physiol . Chair: J. J. McCarthy · Co-Chair: K. A. Murach Track: Cell Signaling, Signal Transduction, Muscle Metabolism, Inflammation/Immunity

1:30 Hypertophy, Satellite Cells and Skeletal Muscle Damage, Kevin Murach, University of Kentucky

1:50 The Development of Skeletal Muscle Hypertrophy through Resistance Training: The Role of Muscle Damage and Muscle Protein Synthesis, Felipe Damas, University of São Paulo

2:10 The Role of Extracellular Vescicles in Skeletal Muscle Regeneration, Kathryn Myburgh, Stellenbosch University

2:30 The Role of Pericytes in the Repair of Skeletal Muscle Damage, Marni Boppart, University of Illinois

PROGRAM 2019 | 45

170 Using Writing to Teach and Assess Undergraduate Physiology Students


Sponsored By: Teaching of Physiology Section • Cosponsored By: Advances in Physiology Education Chair: L. C. Anderson

1:30 Writing is Re-Writing: Using Writing Intensive Projects in an Undergraduate Exercise Physiology Course, Dean Calsbeek, Northwestern College

1:55 Using Written Tests to Assess Student Thinking in Undergraduate Physiology: Methods and Lessons Learned, Kerry Richie, University of Guelph

2:15 Connections and Integrative Summaries: The Write Stuff!, Anne Crecelius, University of Dayton

2:35 Grading Writing Assignments in a Way that Promotes Active Learning: The Minimal Marking Technique, Peter English, University of Texas at Austin

171 Aging, Exercise and Heart Failure: Common Connections and New Targets

Featured Topic SUN, 1:30 p.m.-3:00 p.m., Convention Center, W312A

Sponsored By: Cardiovascular Section • Cosponsored By: AJP - Heart and Circulatory Physiology and J . Appl . Physiol . · Chair: C. Emter · Co-Chair: C. Wrann

1:30 Aging, Exercise and Heart Failure: Looking for New Targets, Anthony Rosenzweig, Massachusetts General Hospital

2:00 Impact of Acute Antioxidant Administration on Inflammation and Vascular Function in Heart Failure with Preserved Ejection Fraction, S.M. Ratchford, H.L. Clifton, J. Gifford, D.T. LaSalle, T.S. Thurston, K. Bunsawat, J. Theisen, R.S. Richardson, J.B. Wright, J.J. Ryan, D.W. Wray, George E . Whalen VA Medical Center, University of Utah and Brigham Young University

2:15 Chronic Low-Intensity Exercise Training Prevents Coronary Artery Stiffness via Inhibiton of Perivascular Adipose-Secreted Advanced Glycation End Products in Aortic-Banded Mini-Swine, A. Ouyang, T. D. Olver, B.S. Ferguson, C.A. Emter, B.S. Fleenor, University of Kentucky, University of Missouri-Columbia and Ball State University

46 | ANNUAL MEETING


2:30 Intact DNA Repair in Differentiated Cardiomyocytes is Essential for Maintaining Cardiac Function in Response to Physiological Stimulus, M. de Boer, M. te Lintel Hekkert, I. Krabbendam-Peters, L.A. Blonden, J.H. Hoeijmakers, D.J. Duncker, Erasmus MC, Netherlands, CECAD Forschungszentrum and Universität zu Köln, Germany

2:45 The Effects of Aging and Exercise on Glial Cell Line-Derived Neurotrophic Factor Content in Rat Hearts, G. Almeida Alves, J. Spitsbergen, Western Michigan University

172 Autonomic Anti-Inflammatory Mechanisms: Which Branch Trumps?

Featured Topic SUN, 1:30 p.m.-3:00 p.m., Convention Center, W311D

Sponsored By: Neural Control and Autonomic Regulation Section Chair: S. Harwani · Co-Chair: G. Pham

1:30 C1 Neurons Mediate a Stress-Induced Anti-Inflammatory Reflex in Mice, Patrice Guyenet, University of Virginia School of Medicine

2:00 The Chemoattraction of Immune Cells into the Hypothalamic Paraventricular Nucleus Elicits Sympathetically-Mediated Blood Pressure Elevations in Hypertension, K. Elsaafien, W.S. Korim, C.N. May, S.T. Yao, Florey Institute of Neuroscience and Mental Health, Australia, Wade Institute of Entrepreneurship, Australia and The University of Melbourne, Australia

2:15 ADAM17 on Glutamatergic Neurons Contributes to Peripheral Immune Activation through Increasing Sympathetic Activity, J. Xu, A. Molinas, A. Zsombok, E. Lazartigues, LSUHSC-New Orleans and Tulane University Medical School

2:30 Disruption of Splenic Nerve-to-Spleen Neurotransmission Worsens Disease Outcome in a Murine Model of Systemic Lupus Erythematosus, K.W. Mathis, G.S. Pham, D.N. Kulp, UNT Health Science Center

2:45 Neuro-Immune Mechanisms and Pulmonary Fibrosis, J. Yu, Z-b. Deng, J. Roman, Robley Rex VAMC and University of Louisville

173 Hans Ussing Lecture of the Epithelial Transport Group

Featured Topic SUN, 1:30 p.m.-3:00 p.m., Convention Center, W311C

Sponsored By: Epithelial Transport Group • Cosponsored By: AJP - Cell Physiology Chair: S. Keely · Co-Chair: M. Kortenoeven Track: Ion Channels and Transporters, Cell Signaling, Signal Transduction

PROGRAM 2019 | 47

1:30 Epithelial Transport in Digestive Diseases – Mice, Monolayers and Mechanisms, Kim Barrett, University California, San Diego

2:00 Basolateral Calcium Sensing Receptor Mediated Regulation of TRPV6-Dependent Transcellular Calcium Absorption, J. Lee, X. Liu, D. O’Neill, M.R. Beggs, P. Weissgerber, V. Flockerzi, X-Z. Chen, H. Dimke, T. Alexander, University of Alberta, Canada, Women and Children’s Health Research Institute, Canada, Universität des Saarlandes, Germany and University of Southern Denmark, Denmark

2:15 Gout Causing ABCG2 Mutation Results in Intestinal Net Urate Transport Defect, Hyperuricemia and Altered Metabolic Phenotype, M.H. Kazi, R.M. Lewis, O.M. Woodward, University of Maryland School of Medicine

2:30 Claudin-2 Confers Calcium Permeability to the Jejunum and Ileum in Early Life, M.R. Beggs, A. Plain, J.J. Lee, R. T. Alexander, University of Alberta, Canada

2:45 High Mobility Group Box-1 Increases Epithelial Sodium Channel Activity and Inflammation in Small Airway Epithelial Cells, G.J. Grant, C. Coca, M.N. Helms, University of Utah School of Medicine

174 pH Homeostasis and Acid-Base Transport

Featured Topic SUN, 1:30 p.m.-3:00 p.m., Convention Center, W311A

Sponsored By: Cell and Molecular Physiology Section • Cosponsored By: AJP - Cell Physiology Chair: M. Parker · Co-Chair: M. Romero Track: Ion Channels and Transporters, Cell Signaling, Signal Transduction

1:30 CryoEM Structure of Human NBCe1, Ira Kurtz, University of California Los Angeles

2:00 Regulation of Cl- in Signaling and Ion Transport by IRBIT-Mediated Recruitment

of Multiple Kinase and Phosphatase Pathways, L. Vachel, N. Shcheynikov, O. Yamazaki, M. Fremder, E. Ohana, A. Son, D. M. Shin, A. Yamazaki-Nakazawa, C-R. Yang, M.A. Knepper, S. Muallem, NIH, Ben Gurion University of the Negev, Israel and Yonsei University College of Dentistry, Republic of Korea

2:15 NBCe1 in the Kidney and Lower Urogenital Tract, P.Z. Romero, H.L. Holmes, M.T. Cadena, S.J. Gibbons, G. Farrugia, C.M. Vezina, M.F. Romero, Mayo Clinic and University WI-Madison

2:30 NBCe1 is a Novel Regulator of Pancreatic β-cell Function in Diabetes, M. Brown, H. Holmes, K. Rakshit, N. Javeed, M. Romero, A. Matveyenko, Mayo Clinic

2:45 Sex Differences in Acidosis-Stimulated Renal Ammonia Metabolism, A.N. Harris, H-W. Lee, L. Fang, J.W. Verlander, I. D. Weiner, University of Florida and GVAMC

48 | ANNUAL MEETING


175 Sex Specific Differences in Obesity Induced Hypertension

Featured Topic SUN, 1:30 p.m.-3:00 p.m., Convention Center, W311H

Sponsored By: Endocrinology and Metabolism Section Chair: M. J. Barnes · Co-Chair: S. D. Primeaux Track: Muscle Metabolism, Nutrition/Diet, Metabolic Programming/Epigenetics

1:30 Sex Steroids Predispose Females to Obesity-Associated Hypertension, Eric Belin De Chantemele, Augusta University

2:00 Sex Specific Differences in a Lipodystrophy-induced Hypertension Mouse Model, E. Gatineau, W. Su, M. Gong, F. Yiannikouris, University of Kentucky

2:15 Early Inhibition of Angiotensin Converting Enzyme Abolishes the Androgen-Mediated Blood Pressure Increase in a Model of PCOS, E.D. Torres Fernandez, A. Subauste, R.M. Vinson, H. Zhang, C.T. Case, S.M. Stockton, Y.P. Zuchowski, D.G. Romero, L.L. Yanes Cardozo, University of Mississippi Medical Center

2:30 Reduction of Maternal Adiposity Attenuates Leptin Expression during Pregnancy in The Preeclamptic-like BPH/5 Mouse, K.N. Olson, D. Reijnders, C-C. Liu, V. Gomes, L.M. Redman, J.L. Sones, LSU School of Veterinary Medicine and Pennington Biomedical Research Center

2:45 Combined Perinatal and Offspring High-Fat Diet Exaggerates Body Mass and Adiposity but not Blood Pressure Levels during Pregnancy of These Offspring, F.T. Spradley, University of Mississippi Medical Center

176 Translational Physiology Highlights

Featured Topic SUN, 1:30 p.m.-3:00 p.m., Convention Center, W311EF

Sponsored By: Translational Physiology Interest Group Chair: B. K. McConnell · Co-Chair: J. K. Jeong

The Autonomic Nervous System in Cardiovascular Disease

1:30 Antioxidant Effect of Resveratrol on Autonomic Cardiocirculatory Control in Heart Failure Rats, M.d. T. Durand, M.P. L. Durão, S.A. B. A. de Sousa, J. P. Miguel, R.M. Lataro, C. A.A. Silva, J.H. Amaral, H.C. Salgado, University of Ribeirão Preto, Brazil, Federal University of Santa Catarina, Brazil and Ribeirão Preto Medical School, Brazil

PROGRAM 2019 | 49

1:36 The Impact of Chronic Antioxidant Administration on Sympathetic Nervous System Activity and Vascular Function in Heart Failure Patients with a Reduced Ejection Fraction, K. Bunsawat, S.M. Ratchford, J.K. Theisen, S-H. Park, J. Stehlik, O. Wever-Pinzon, S. Drakos, R.S. Richardson, D. W. Wray, University of Utah, Geriatric Research, Education and Clinical Center, Salt Lake City VAMC and University of Utah Center on Aging

1:42 Sympathomodulation in Heart Failure: A Role for Stellate Ganglia Nrf2, J. Shanks, L. Gao, I.H. Zucker, University of Nebraska Medical Center

1:48 Epidural Stimulation Improves Cerebral Autoregulation and Autonomic Cardiac Control in Humans with Spinal Cord Injury, S. Saleem, D.A. Darrow, T.I. Netoff, Y-C. Tzeng, U. Samadani, A. Krassioukov, A. Phillips, COMSATS University Islamabad, Sahiwal Campus, Pakistan, University of Minnesota, University of Otago, New Zealand, Hennepin County Medical Center, University of British Columbia, Canada and University of Calgary, Canada

1:54 The Availability of Sympathetic Neurotransmitter Release for Nerve Stimulation is Enhanced in Mesenteric Arteries from Long-Term Paraplegic and Tetraplegic Rats, S. Sangsiri, H.L. Lujan, S.E. DiCarlo, R. Fernandes, J.J. Galligan, G.D. Fink, H. Xu, Michigan State University and Thammasat University, Thailand

2:00 Epidural Spinal Cord Stimulation for Neuropathic Pain Reduces Blood Pressure in Patients with Hypertension Independent of Pain Relief: A Retrospective Study, S.W. Holwerda, M.T. Holland, A.L. Green, M.T. Collins, A.C. Pearson, G.L. Pierce, University of Iowa and University of Oxford, United Kingdom

2:06 Roundtable Discussion

The Influence of Early Insults on Cardiometabolic Function

2:14 Childhood Adversity Impairs the Autonomic Response to Acute Stress, J. Looney, M.A. Tucker, J. H. Jeong, D.M. Pollock, J.S. Pollock, R.A. Harris, Augusta University, University of Alabama at Birmingham and University of Ulster, United Kingdom

2:20 Parents Exacerbated Fructose Intake Causes Early Cardiovascular Autonomic Dysfunctions in Offspring, C. Paixão dos Santos, D. Ribeiro Silva, D. Da Silva Dias, A. Araujo, N. Bernardes, F. Fernardes Conti, M.C. Irigoyen, K. De Angelis, Federal University of São Paulo, Brazil, Universidade Nove de Julho, Brazil, Nova Southeastern University and University of São Paulo, Brazil

2:26 Exposure to Microbial Infection In Utero Has Long-Term Effects on the Cardiovascular Response to Angiotensin II and Forebrain Gene Expression in Rats, J. Watkins, M. Von Chamier, M.B. Brown, L. Hayward, University of Florida

2:32 Early Life Stress-Induced Increases in Adiposity in Mice are Prevented by the Adipose Tissue-Specific Abrogation of Neuropeptide Y Receptor 2, J.R. Leachman, C. Dalmasso, T. Jones, T. Seward, B.K. Taylor, A.S. Loria, University of Kentucky and University of Pittsburgh

50 | ANNUAL MEETING


2:38 Vaping During Pregnancy Results in Arterial Stiffness in Offspring, E. Aboaziza, J. O’Reilly, J. Moore, S. McLaughlin, I. M. Olfert, P. Chantler, West Virginia University School of Medicine, West Virginia Clinical and Translational Science Institute and WVU Animal Models and Imaging Facility


2:50 Roundtable Discussion

177 Ernest Starling Distinguished Lectureship of the Water and Electrolyte Homeostasis Section

Lecture SUN, 3:30 p.m.-4:30 p.m., Convention Center, W315

Sponsored By: Water and Electrolyte Homeostasis Section

3:30 There’s NO Place Like Home(ostasis), Jennifer Pollock, University of Alabama at Birmingham

178 Hugh Davson Distinguished Lectureship of the APS Cell and Molecular Physiology Section

Lecture SUN, 3:30 p.m.-4:30 p.m., Convention Center, W311EF

Sponsored By: Cell and Molecular Physiology Section Track: Ion Channels and Transporters

3:30 Membranes, Music and Economics: What I Learned from CFTR, Bob Dylan and Adam Smith, David Dawson, Oregon Health & Science University

179 MCS Landis Award Lecture and Business Meeting

Lecture SUN, 3:30 p.m.-5:30 p.m., Convention Center, W308AB


3:30 Arteriolar Vascular Smooth Muscle Cells: Mechanotransducers in a Complex Environment, Michael Hill, University of Missouri

PROGRAM 2019 | 51

180 Autonomic Control of Metabolism


Sponsored By: Neural Control and Autonomic Regulation Section Chair: V. M. Aubert

3:30 Gut’s Sympathetic Nerve Regulate Energy and Metabolism after Gastric Bypass, Mohamad Mokadem, University of Iowa

4:00 The Role of the Gut-Brain Axis in Regulating Glucose Homeostasis, Darleen Sandoval, University of Michigan

4:30 Manipulating the Vagus Nerve and Immunometabolism Using Pharmacogenetics, Laurent Gautron, University of Texas Southwestern

181 Carotid Body Sensing: More than Just an O2 Sensor

Symposium SUN, 3:30 p.m.-5:00 p.m., Convention Center, W308CD

Sponsored By: Experimental Biology Symposium Series Chair: P. M. McFarlane · Co-Chair: R. Bavis

3:30 Revisit Gasotransmitters in Carotid Body Oxygen Sensing, Ying Jie Peng, University of Chicago

4:00 Carotid Body: The Link Between Oxygen and Metabolic Sensing, Silvia Conde, Nova Medical School, New University of Lisbon

4:30 The Effect of Inflammation on Peripheral and Central Reflexes that Control Breathing during Development, Estelle Gauda, University of Toronto, The Hospital for Sick Children

52 | ANNUAL MEETING


182 Common Pathways of Angiotensin on Cardiovascular and Respiratory Responses Induced by High-Fat-Diet, Hypoxia and Renal Hypertension

Symposium SUN, 3:30 p.m.-5:00 p.m., Convention Center, W312A

Sponsored By: Pan-American Societies (SFiB) • Cosponsored By: AJP - Heart and Circulatory Physiology Chair: E. Colombari · Co-Chair: R. Del Rio

3:30 Cardiovascular and Respiratory Changes in High-Fat Diet Fed Adult Rats and in Offspring of High-Fat Diet Fed Dams, Débora Colombari, School of Dentistry of Araraquara - UNESP

4:00 Angiotensin II-Induced Endoplasmic Reticulum Stress in the RVLM Contributes to Cardiorespiratory Impairment in High-Output Heart Failure, Rodrigo Del Rio, P . Universidad Católica de Chile

4:30 Renovascular Hypertension Elevates Pulmonary Ventilation in Rats by Carotid Body-Dependent Mechanisms, Eduardo Colombari, School of Dentistry of Araraquara - UNESP

183 Hormonal Influences on Tissue Remodeling

Symposium SUN, 3:30 p.m.-5:00 p.m., Convention Center, W311A

Sponsored By: Endocrinology and Metabolism Section Chair: S. H. Lindsey · Co-Chair: E. Y. Gohar Track: Muscle Metabolism, Inflammation/Immunity, Cell Signaling, Signal Transduction

3:30 Impact of Estrogen on Left Ventricular Remodeling and Function, Jason Gardner, LSUHSC-New Orleans

3:50 Dysregulation of Uteroplacental and Vascular Remodeling and the Matrix Metalloproteinases, Gelatinases, Collagenases and Matrilysin During Hypertension in Pregnancy, Raouf Khalil, Harvard University

4:10 Membrane-Initiated Estrogenic Signaling and Vascular Remodeling, Benard Ogola, Tulane University

4:30 Interactive Effects of Exercise and estrogen on the Skeletal System, Wendy Kohrt, Tulane University of Colorado Denver

PROGRAM 2019 | 53

184 Innovative Imaging Approaches in Gastrointestinal Epithelial Biology


Sponsored By: GI and Liver Physiology Section • Cosponsored By: AJP - Gastrointestinal and Liver Physiology Chair: K. Edelblum

3:30 Microbial Exploitation of Host Calcium Signaling Pathways in Human Enteroids, Joseph Hyser, Baylor College of Medicine

4:00 Intravital Imaging of Goblet Cell-Associated Antigen Passages, Kathryn Knoop, Washington University

4:30 Visualization of Intestinal Stem Cell Clones in Crypt Repair Using Tissue Transparency, Brent Polk, Childrens Hospital of Los Angeles, University of Southern California

185 Mechanism of Hypertension-Induced Kidney Damage

Symposium SUN, 3:30 p.m.-5:00 p.m., Convention Center, W311D

Sponsored By: Renal Section • Cosponsored By: AJP - Renal Physiology Chair: N. Li · Co-Chair: M. C. Prieto Track: Cell Signaling, Signal Transduction, Inflammation/Immunity

3:30 Hypertension and the Progression of Chronic Kidney Disease, Karen Griffin, Loyola University Medical Center

3:50 Novel Signaling in Renal Autoregulation, Zhengrong Guan, University of Alabama at Birmingham

4:10 The Role of Renal Perfusion Pressure in Renal Immune Cell Infiltration, Louise Evans, University of Minnesota

4:30 Molecular Signals Mediating Hypertension-Induced Renal Injury, Ningjun Li, Virginia Commonwealth University

54 | ANNUAL MEETING


186 Nrf2 as a Promising Target for Increasing Healthspan and Diminishing Aging-Related Chronic Diseases


Sponsored By: Environmental and Exercise Physiology Section • Cosponsored By: Physiological Reviews Chair: K. L. Hamilton Track: Muscle Metabolism, Cell Signaling, Signal Transduction

3:30 Brief Overview of Nrf2 in the Context of Exercise and the Environment, Karyn Hamilton, Colorado State University

3:50 An Overview of Promising Phytochemical and Synthetic Nrf2 Activators: Potential for Slowed-Aging Interventions, Joe McCord, University of Colorado School of Medicine and Pathways Bioscience

4:10 Nrf2 at the Crossroad Between Aging and Alzheimer’s Disease, Salvatore Oddo, Arizona State University

4:30 Nrf2 and Aging-Related Disease: Epigenetics and Cancer, Tony Ah-Ng Kong, Rutgers University

187 Nutrition as a Biological Variable: Considerations for the Future of Physiology Research

Symposium SUN, 3:30 p.m.-5:00 p.m., Convention Center, W311C

Sponsored By: Nutrition Physiology Interest Group • Cosponsored By: AJP - Gastrointestinal and Liver Physiology and J . Appl . Physiol Chair: T. G. Anthony · Co-Chair: J. I. Baum Track: Nutrition/Diet

3:30 Considering Nutrition as a Biological Variable and the Strategic Plan for NIH Nutrition Research, Christopher Lynch, NIH, ONR

4:00 Food Intake in Clinical Research Studies: How Much Dietary Control and for How Long?, Elizabeth Parks, University of Missouri

4:30 Nutrition and Circadian Rhythms in Obesity, Joseph Bass, Northwestern University

PROGRAM 2019 | 55

188 Sex and Metabolic Health: Emerging Challenges and Discoveries

Symposium SUN, 3:30 p.m.-5:00 p.m., Convention Center, W311H

Sponsored By: Sex/Gender Research Interest Group Chair: B. T. Alexander · Co-Chair: B. B. Rice

3:30 Androgens and the Metabolic Consequences of PCOS, Licy Yanes, University of Mississippi Medical Center

4:00 The Impact of Sex and Age in the Developmental Origins of Metabolic Health, Kevin Pearson, University of Kentucky

4:30 Estrogens and Aging in Metabolic Disease, Michaela Devries (-Aboud), University of Waterloo

189 Sex and Gender in Respiratory Physiology

Featured Topic SUN, 3:30 p.m.-5:00 p.m., Convention Center, W311G

Sponsored By: Respiration Section • Cosponsored By: AJP - Lung Cellular and Molecular Physiology Chair: P. Silveyra · Co-Chair: Y. Prakash Track: Cell Signaling, Signal Transduction, Inflammation/Immunity

3:30 Gender Disparity in Asthma, are Hormones to Blame?, Dawn Newcomb, Vanderbilt University School of Medicine

4:00 Estrogen Receptors Differentially Regulates Intracellular Calcium Handling in Human Asthmatic Airway Smooth Muscle Cells, S. Bhallamudi, J. Connell, M. Thompson, C. Pabelick, Y. S. Prakash, V. Sathish, North Dakota State University and Mayo Clinic

4:15 Sex Differences in Human Monocyte/Macrophages in Response to IL-4, M. Becerra Diaz, N.M. Heller, Johns Hopkins University and SOM

4:30 Role of Estrogen on Alveolar Macrophage Polarization in Response to Particulate Matter Exposure, N. Fuentes, J. Pesantez, M. Nicoleau, R. Vander Wal, Z. Chroneos, P. Silveyra, Penn State College of Medicine, Franklin & Marshall College, Penn State University and University of North Carolina at Chapel Hill

4:45 HIF-1 alpha Mediates Sex-specific miR-30a Expression in Neonatal Hyperoxic Lung Injury: Implications for Bronchopulmonary Dysplasia, Y. Zhang, X. Dong, K. Lingappan, Baylor College of Medicine

56 | ANNUAL MEETING


190 David Bruce Undergraduate Poster Session and Horwitz/Horowitz Awards Ceremony

Award Competition SUN, 3:30 p.m.-5:00 p.m., Convention Center, Valencia Ballroom D

Sponsored By: APS Education Committee Chair: J. L. Osborn

191 Water and Electrolyte New Investigator Award Lecture


Sponsored By: Water and Electrolyte Homeostasis Section

4:30 The Physiology of Decompensation: From Bench to Bedside, Michael Hulstrom, Uppsala University

192 APS Business Meeting

Business Meeting SUN, 5:15 p.m.-5:40 p.m., Convention Center, W314

Sponsored By: APS

193 Physiology in Perspective: The Walter B. Cannon Award


Sponsored By: APS

5:40 From Salt to Stones to CKD: Anion Transporters in Health and Disease, Peter Aronson, Yale University School of Medicine

PROGRAM 2019 | 57

ORAL SESSIONSMONDAY, APRIL 8

279 Career Planning: No Scientist Left Behind (Monday)

Symposium MON, 7:00 a.m.-8:00 a.m., Convention Center, W311C


7:00 Building Bridges for a Sustainable Career Path and Workforce Diversity, Irving Vega, Michigan State University

280 Marketing Yourself for a Successful Career II

Symposium MON, 7:00 a.m.-8:00 a.m., Convention Center, W311B


7:00 Career Development Opportunities Outside the Academia - And How to Get There, Niclas Lindqvist, Svensk Medicin AB


Symposium MON, 7:00 a.m.-8:00 a.m., Convention Center, W311D

Sponsored By: Careers in Physiology Committee Chair: B. Becker · Co-Chair: C. Trimby Track: Career Central

7:00 Mentoring, Management and Other Nuts and Bolts, Jennifer Pollock, University

of Alabama at Birmingham

7:30 Mentoring, Management and Team Science, Stan Andrisse, Johns Hopkins University

58 | ANNUAL MEETING


282 Claude Bernard Distinguished Lectureship of the APS Teaching of Physiology Section

Lecture MON, 8:30 a.m.-9:30 a.m., Convention Center, W309AB

Sponsored By: Teaching of Physiology Section Supported by: APS Strategic Partner ADInstruments

8:30 Evidence Based Teaching: So That All Students May Learn, Mary Pat Wenderoth, University of Washington

283 Robert M. Berne Distinguished Lectureship of the APS Cardiovascular Section

Lecture MON, 8:30 a.m.-9:30 a.m., Convention Center, W308AB

Sponsored By: Cardiovascular Section

8:30 Cardiac Metabolism: An Odyssey of Energy and Beyond, Rong Tian, University of Washington

284 Diabetes: A Metabolic Karma

Symposium MON, 8:30 a.m.-10:00 a.m., Convention Center, W311C

Sponsored By: Translational Physiology Interest Group • Cosponsored By: Physiological Reviews Chair: M. A. Carrillo Sepulveda · Co-Chair: J-X. Chen

8:30 Redox Imbalance in the Diabetic Milieu: Novel Targets, Karin Jandeleit-Dahm, Monash University

9:00 Epigenetic Mechanisms in Diabetic Complications and Metabolic Memory, Rama Natarajan, Beckman Res . Inst . of the City of Hope

9:30 Atherosclerosis Risk in Diabetes: It Begins in the Bone Marrow, Edward Fisher, New York University School of Medicine

PROGRAM 2019 | 59

285 Neural Circulatory Mechanisms Linking Sleep Loss to Hypertension

Symposium MON, 8:30 a.m.-10:00 a.m., Convention Center, W311G

Sponsored By: Neural Control and Autonomic Regulation Section • Cosponsored By: AJP - Heart and Circulatory Physiology Chair: J. K. Limberg · Co-Chair: V. K. Somers

8:30 Sympathoexcitatory Effects of Acute and Chronic Sleep Deprivation: Insights from Animal Research, Monica Andersen, Universidade Federal de São Paulo

9:00 Impact of Sleep Restriction on Cardiovascular Autonomic Modulation and Blood Pressure Control in Healthy Subjects, Naima Covassin, Mayo Clinic

9:30 Insomnia, Short Sleep Duration and Risk of Hypertension: Current Experimental Evidence, Jason Carter, Michigan Technological University

286 Oxidative Stress and Post-translational Modification of Protein Thiols in Cell Signaling

Symposium MON, 8:30 a.m.-10:00 a.m., Convention Center, W311EF

Sponsored By: Experimental Biology Symposium Series • Cosponsored By: Physiological Reviews and AJP - Cell Physiology Chair: M. N. Helms · Co-Chair: C. Downs

8:30 Resin-Assisted Enrichment of Thiols as a General Strategy for Proteomic Profiling of Cysteine-Based Reversible Modification, Wei-Jun Qian, Pacific Northwest National Laboratory

9:00 Glutathione and Alterations in Redox Status During Embryonic Development, Jason Hansen, Brigham Young University

9:30 Dysregulated Redox Signaling, Yvonne Janssen -Heininger, University of Vermont

60 | ANNUAL MEETING


287 EEP Impact Award Featured Topic: Modulation of Systemic and Tissue Metabolism via Differences in Activity and Fitness

Featured Topic MON, 8:30 a.m.-10:00 A a.m. M, Convention Center, W308CD

Sponsored By: Environmental and Exercise Physiology Section Chair: E. M. Morris · Co-Chair: R. S. Rector Track: Metabolic Programming/Epigenetics, Muscle Metabolism

8:30 Exercise, Aerobic Capacity and Protection Against Metabolic Disease, John Thyfault, University of Kansas Medical Center

9:00 A Single Resistance Exercise Session Reduces High-Fat Meal-Induced Impairments in Conduit Artery Function and Microvascular Reactivity, P.M. Tomko, R.J. Colquhoun, N.F. Banks, C.M. Sciarrillo, N.A. Koemel, S.R. Emerson, N.D. Jenkins, Oklahoma State University

9:15 Associations between Aerobic Capacity, Hepatic Bile Acid Synthesis and Fecal Bile Acid Concentration in Humans, A. Maurer, K.E. Mercer, S.H. Adams, J. Thyfault, University of Kansas Medical Center, University of Arkansas for Medical Sciences and Arkansas Children’s Nutrition Center

9:30 Ketogenic Diet in Combination with Voluntary Exercise Impacts Markers of Hepatic Metabolism and Oxidative Stress in Male and Female Rats, M.P. Moore, R.P. Cunningham, T.J. Kelty, L.R. Boccardi, N.R. Nguyen, F.W. Booth, R.S. Rector, Harry S Truman Memorial Veterans Medical Center and The University of Missouri

9:45 Uncoupling Protein 1 and Exercise Induced Browning of White Adipose Tissue is Absent at Thermoneutrality, P. Aldiss, J. Lewis, F. Ebling, D. Bookcock, H. Budge, M. Symonds, The University of Nottingham, United Kingdom and Nottingham Trent University, United Kingdom

288 Effects of Diet on Emotion and Motivated Behavior

Featured Topic MON, 8:30 a.m.-10:00 a.m., Convention Center, W311D

Sponsored By: CNS Section Chair: Y. Silberman · Co-Chair: J. Barson Track: Neuroscience, Nutrition/Diet

8:30 Cross-Sensitization to Binge Alcohol Intake Following Binge Intake of Palatable Diets, C.R. Coker, E. Aguilar, Y. Silberman, The Pennsylvania State University College of Medicine

PROGRAM 2019 | 61

9:00 High Fat Diet Modulation of Nucleus Accumbens Dopamine Function, Sara Jones, Wake Forest School of Medicine

9:30 The Glucagon-Like Peptide-1 (GLP-1) System is Modulated by Acute and Chronic Exposure to Alcohol: Findings from Human Laboratory and Brain Postmortem Studies, M. Farokhnia, M.R. Lee, H. Sun, P. Suchankova, L. Leggio, NIH, University of Gothenburg, Sweden and Brown University

9:45 Central Amygdala Angiotensin Type 2 Receptor (AT2R) Activation Reduces

Fear-Related Behavior, Z. Yu, A. P. Swiercz, E. G. Krause, P.J. Marvar, The George Washington University and University of Florida

289 Mapping The Lung: Leveraging Emerging Technologies To Better Understand Pulmonary Disease

Featured Topic MON, 8:30 a.m.-10:00 a.m., Convention Center, W311H

Sponsored By: Respiration Section • Cosponsored By: AJP - Lung Cellular and Molecular Physiology and Physiological Reviews Chair: M. F. Beers · Co-Chair: J. Bastarache Track: Inflammation/Immunity, Cell Signaling, Signal Transduction, Metabolic Programming/Epigenetics

8:30 Using Patient Derived iPS Cells to Unravel Mechanistic Pathways Underlying Rare and Common Lung Diseases, Darrell Kotton, Boston University

9:00 Induced Pluripotent Stem Cell-Derived Basal Cells Provide A Novel Source of Multi-lineage Airway Epithelial Cells, A.L. Ryan, E.J. Quiroz, J. Magallanes, B.A. Calvert, S. Petraki, R. Elteriefi, J. Gao, USC

9:15 Transcriptional Characterization of Human Lung Cells Identifies Novel Markers for Mesenchymal Lineages, S. Danopoulos, S. Bhattacharya, T.J. Mariani, D. Al Alam, Children’s Hospital Los Angeles and University of Rochester

9:30 Deconstructing Pulmonary Fibrosis at Single-Cell Resolution, J.A. Kropski, C.L. Calvi, A.C. Habermann, A. Guitierrez, N. Winters, J.C. Rodenberry, W. McDonnell, C.M. Shaver, L.B. Ware, S. Mallal, T.S. Blackwell, N.E. Banovich, Vanderbilt University Medical Center, Vanderbilt University and Translational Genomics Research Institute

9:45 High Resolution Evaluation of Human Airway Cell Diversity Towards Understanding the Cellular Composition and Function of the Distal Human Airways, M.C. Basil, W. Zacharias, J. Katzen, J. Carl, S. Li, M. Morley, J. Englehardt, E. Cantu; III, E. Morrisey, University of Pennsylvania, University of Cincinnati and Carver College of Medicine

62 | ANNUAL MEETING


290 Molecular Mechanisms of Cellular Signaling and Transduction

Featured Topic MON, 8:30 a.m.-10:00 a.m., Convention Center, W311A

Sponsored By: Cell and Molecular Physiology Section • Cosponsored By: AJP - Cell Physiology Chair: B. L. Blazer-Yost · Co-Chair: E. Teal Track: Cell Signaling, Signal Transduction

8:30 ACE2 Internalization and Degradation is Controlled by Ubiquitin Ligase NEDD4, B. Ogunlade, J.J. Guidry, E. Lazartigues, C. Filipeanu, Howard University, LSU HSC and SouthEast Louisiana Veterans Health Care System

8:45 FoxO1 Regulates Beige Adipogenesis and Adiposity via Autophagy, Z. Cheng, Z. Tao, L. Liu, L. Zheng, Virginia Tech

9:00 Histones Activate Toll-Like Receptor 9 to Trigger Calcium Oscillations in Rat Pancreatic Acinar Cells, Z. J. Cui, H. Y. Guo, Beijing Normal University, People’s Republic of China

9:15 NR4A2 Inhibits ERK-Mediated Protein Synthesis and Cell Growth in Response to Beta-Adrenergic Stimulation in Cardiomyocytes, S. Ashraf, Y. Hegazy, R. Harmancey, University of Mississippi Medical Center

9:30 Atg16L1 Knockout Induces Insulin Resistance through Proteasomal IRS1 Degradation, Mediated by the Induction of ER Stress, S. Frendo-Cumbo, J. Jaldin-Fincati, J.H. Brumell, A. Klip, The Hospital for Sick Children, Canada and University of Toronto, Canada

9:45 Alterations in Sirt1 Attenuate Host Defense to Pneumococcal Infection in Sickle Cell Disease, B. Bedi, B-Y. Kang, C. M. Hart, R.T. Sadikot, Emory University/Atlanta VA Medical Center and Emory University

291 Perinatal Reprogramming of Respiratory Control

Featured Topic MON, 8:30 a.m.-10:00 a.m., Convention Center, W312B

Sponsored By: Respiration Section • Cosponsored By: AJP - Lung Cellular and Molecular Physiology Chair: A. Huxtable · Co-Chair: T. Baker Track: Cell Signaling, Signal Transduction, Neuroscience, Ion Channels and Transporters

8:30 Sex-Specific Perinatal Programming of Neuro-Immune Function by the Early-Life Environment, Jessica Bolton, University of California-Irvine

PROGRAM 2019 | 63

9:00 Microglial Depletion Rescues Deficits in Compensatory Respiratory Plasticity in Adult Offspring Exposed to Gestational Intermittent Hypoxia, M.G. Gumnit, C. Mickelson, A. Meza, A. Agbeh, A. Ewald, K. Braegelmann, J. Ouellette, J.J. Watters, T.L. Baker, University of Wisconsin-Madison

9:15 The Transcriptomic Profiles of Microglia from Respiratory Control Centers in Adult Offspring Exposed to Gestational Intermittent Hypoxia Differ by Sex and CNS Region, A.C. Ewald, E.A. Kiernan, T.L. Baker, J.J. Watters, University of Wisconsin - Madison

9:30 Microglia Modulate Changes in Dorsal Motor Nucleus (DMNV) Neuron Excitability Following Sustained Hypoxia Exposure During a Critical Period of Neonatal Development, C. Mayer, P. Mac Farlane, Case Western Reserve University

9:45 Thyroid Hormone Supplementation Dampens GABAergic Inhibition of the Brainstem Respiratory Network in Newborn Rat, J-P. Rousseau, R. Kinkead, Université Laval, Canada

292 Hot Topics in Muscle Biology

Featured Topic MON, 8:30 a.m.-10:00 a.m., Convention Center, W312A

Sponsored By: Muscle Biology Group Chair: X. Wang · Co-Chair: W. E. Mitch Track: Muscle Metabolism

8:30 Muscle-Kidney Cross-Talk: miR23, Sarcopenia and Renal Fibrosis in Chronic Diseases, Stephen Price, Brody School of Medicine at East Carolina University

9:00 Key Facilitator Proteins that Mediate Sarcolemma Membrane Repair have Potential as Therapeutics for Muscle Disease and Injury, T.A. Bodnar, A. Rose, K. McElhanon, B. Paleo, S. Bhattacharya, E. Beck, N. Weisleder, Dorothy M . Davis Heart and Lung Research Institute and The Ohio State University

9:15 Muscle-Derived Exosome/miRNA-26a Attenuates Skeletal Muscle Wasting and Cardiomyopathy in Chronic Kidney Disease (CKD) Mice, B. Wang, B.c. Liu, Zhong Da Hospital and Southeast University School of Medicine, People’s Republic of China

9:30 Nix Induced Mitochondrial Fission, Mitophagy, and Myocyte Insulin Resistance are Abrogated by PKA Phosphorylation, J.W. Gordon, S. da Silva Rosa, J. Field, M. Martens, V.W. Dolinsky, M. Aliani, University of Manitoba, Canada

9:45 Electrically-Stimulated Acupuncture Improves Muscle Function and Increases Renal Blood Flow through Exosomes-Carried miR-181, A.H. Zhang, J.D. Klein, X.H. Wang, Emory University and Nanjing Medical University, People’s Republic of China

64 | ANNUAL MEETING


293 APS-ASPET Presidential Symposia Series: Microbiome. Gut Microbiota: A Chemical Factory

Symposium MON, 8:30 a.m.-10:00 a.m., Convention Center, W314

Sponsored By: President’s Symposium Series Chair: H. Jeong · Co-Chair: J. Pluznick Track: Microbiome

8:30 Modeling and Measuring the Human Gut Metabonome in Vitro, Emma Allen-Vercoe, University of Guelph

9:00 Molecular Control of the Gut Microbiome, Matthew Redinbo, University of North Carolina

9:30 Chemical Discovery in the Human Microbiota, Emily Balskus, Harvard University

294 Hot Topics in WEH and ETG

Featured Topic MON, 8:30 a.m.-10:00 a.m., Convention Center, W311B

Sponsored By: WEH and ETG Chair: T. Rieg · Co-Chair: M. Beggs Track: Ion Channels and Transporters, Metabolic Programming/Epigenetics, Cell Signaling, Signal Transduction

8:30 Deletion of Epac1 or Epac2 Compromises Renal Na+ Conservation by Decreasing Activity of the Epithelial Na+ Channel (ENaC), V.N. Tomilin, O. Zaika, F. Mei, X. Cheng, O. Pochynyuk, UTHSC at Houston

8:45 Generation of a Tetracycline-Inducible NKCC2 Expressing MDCKI Cell Line, L.L. Rosenbaek, F. Rizzo, O. Staub, R. Fenton, Department of Biomedicine, Aarhus University, Denmark, Department of Neuroscience, University of Copenhagen, Denmark, Dept . of Pharmacology & Toxicology and Lausanne University, Switzerland

9:00 The Effects of Dietary Potassium on Mouse Blood Pressure and Ion Transport, C. Boyd-Shiwarski, C. Weaver, L. Nkashama, K. Connolly, D. Shiwarski, S. Mutchler, A. Marciszyn, A. Subramanya, University of Pittsburgh and Carnegie Mellon University

9:15 Placental Ischemia Influences Developmental Programming in Growth Restricted Offspring, L.E. Coats, G.K. Davis, D.R. Bamrick, B.R. Bakrania, B.T. Alexander, University of Mississippi Medical Center

PROGRAM 2019 | 65

9:30 Reduced Renal Responsiveness to Vasopressin during Preeclampsia, K. Chen, S. Y. Zhang, S.M. Scroggins, G. Deng, J.A. Sandgren, D. Zepeda-Orozco, G.L. Pierce, M.K. Santillan, J.L. Grobe, D.A. Santillan, University of Iowa


295 Carl Ludwig Distinguished Lectureship of the APS Neural Control and Autonomic Regulation Section

Lecture MON, 1:30 p.m.-2:30 p.m., Convention Center, W308AB

Sponsored By: Neural Control and Autonomic Regulation Section

1:30 What Can We Learn about Neural Control of the Circulation by Studying Rhythms in Sympathetic Nerve Activity?, Susan Barman, Michigan State University

296 Edward F. Adolph Distinguished Lectureship of the APS Environmental and Exercise Physiology Section

Lecture MON, 1:30 p.m.-2:30 p.m., Convention Center, W308CD

Sponsored By: Environmental and Exercise Physiology Section Track: Muscle Metabolism

1:30 Skeletal Muscle Atrophy: Multiple Pathways Can Achieve the Same Outcome, Sue Bodine, University of Iowa

297 2019 Annual Marion J. Siegman Lectureship Award

Lecture MON, 1:30 p.m.-3:00 p.m., Convention Center

Sponsored By: APS

1:30 What's the Catch? Lessons Marion Taught me about Mussels, Muscles, and Myosin Binding Protein-C, Samantha P. Harris, University of Arizona

66 | ANNUAL MEETING


298 Brown Adipose Tissue: The Fat that Makes you Thin

Symposium MON, 1:30 p.m.-3:00 p.m., Convention Center, W311EF

Sponsored By: Experimental Biology Symposium Series Chair: M. Symonds

1:30 Recent Advances in the Quantification and Assessment of Brown Function and Distribution in Adult Humans, Aaron Cypess, National Institutes of Health

2:00 The Use of Stem Cells to Generate Brown Adipocytes: Role of Ambient Temperature, Anaid Leija, The Univeristy of Nottingham

2:30 Transgenic Induction on Brown Fat in Large Mammals and Its Impact on Energy Balance, Jianguo Zhao, Chinese Academy of Sciences

299 Crosstalk between Metabolic Disorders and Mitochondrial Oxidative Stress

Symposium MON, 1:30 p.m.-3:00 p.m., Convention Center, W311C

Sponsored By: Endocrinology and Metabolism Section • Cosponsored By: Physiological Reviews Chair: E. I. Dikalov · Co-Chair: M. N. Sack Track: Muscle Metabolism, Metabolic Programming/Epigenetics, Cell Signaling, Signal Transduction

1:30 Mitochondrial Deacetylase Sirt3 in the Crosstalk between Vascular Oxidative Stress and Mitochondrial Dysfunction in Hypertension, Sergey Dikalov, Vanderbilt University Medical Center

2:00 Modulation of Redox Cell Signaling and Metabolism by GCN5L1 Mediated Lysine Acetylation in Gluconeogenesis, Michael Sack, NIH/NHLBI

2:30 Redox Biology and Metabolism in Pulmonary Arterial Hypertension, James West, Vanderbilt University Medical Center

PROGRAM 2019 | 67

300 From the Brainstem to the Heart: Cardio-Respiratory Control in Ectothermic Vertebrates

Symposium MON, 1:30 p.m.-3:00 p.m., Convention Center, W312B

Sponsored By: Comparative & Evolutionary Physiology Section Chair: T. Janes · Co-Chair: J. Conner Track: Neuroscience

1:30 How and Why Vertebrates Match Ventilation and Perfusion of Their Respiratory Systems, Tobias Wang, Aarhus University

1:52 Temperature-Dependence of Respiratory Control in Air Breathing Vertebrates, Lynn Hartzler, Wright State University

2:14 Chemoreception and Reflex Control of Cardiorespiratory Function in Fish, Steven Perry, University of Ottawa

2:36 Modulation of the Lamprey Respiratory Rhythm by Neuronal and Glial Mechanisms, Donatella Mutolo, University of Florence

301 Thoracic and Abdominal Aortic Aneurysm: From Models and Mechanism to Clinical Trials and Therapy Updates

Symposium MON, 1:30 p.m.-3:00 p.m., Convention Center, W312A

Sponsored By: Cardiovascular Section • Cosponsored By: AJP - Heart and Circulatory Physiology Chair: Z. Kassiri · Co-Chair: B. Liu

1:30 Differential Regional Remodeling of Aortic ECM in TAA versus AAA, Zamaneh Kassiri, University of Alberta

1:50 Necroptosis in Abdominal Aortic Aneurysm: Mechanisms and Therapeutic Opportunities, Bo Liu, University of Wisconsin

2:10 Immune Cell-Secreted Serine Proteases in Aortic Aneurysm and Rupture, David Granville, University of British Columbia

2:30 Clinical Trials and Tribulation in Controlling Small AAA Growth, Jonathan Golledge, James Cook University (Australia)

68 | ANNUAL MEETING


302 Updating the History of Insulin; Novel Insights into Regulation of Release, Delivery and Functions

Symposium MON, 1:30 p.m.-3:00 p.m., Convention Center, W311B

Sponsored By: History of Physiology Group Chair: P. Molina · Co-Chair: F. M. Souza-Smith

1:30 Multimodal Regulation of Beta Cell Insulin Secretion: From Nutrients to Surgery, Naji Abumrad, Vanderbilt Medical Center

2:00 The Journey of Insulin in the Body, Amira Klip, University of Toronto

2:30 Insulin Action in the Brain: Linking Neurodegeneration and Alzheimer’s Disease, Suzanne De La Monte, Brown University

303 Advances in Renal Physiology I

Featured Topic MON, 1:30 p.m.-3:00 p.m., Convention Center, W311D

Sponsored By: Renal Section • Cosponsored By: AJP - Renal Physiology Chair: D. Ellison Co-Chair: D. Feng Track: Inflammation/Immunity, Cell Signaling, Signal Transduction, Ion Channels and Transporters

1:30 New CRISPR/Cas9 Mouse Model Confirms Association of Phosphorylation of ACTN4 at Serine 159 with Proteinuria and Focal Segmental Glomerulosclerosis, D. Feng, S. Gurley, I. Stillman, L. Ding, M. Pollak, Beth Israel Deaconess Medical Center and Harvard Medical School, Oregon Health & Science University and Brigham and Women’s Hospital

1:45 A Selective Impairment in the Mechanosensitive Afferent Renal Nerve-Mediated Sympathoinhibitory Reno-Renal Reflex Contributes to Age-Related Hypertension, A.A. Frame, F.J. Puleo, E. Faudoa, J.D. Moreira, R.D. Wainford, Boston University School of Medicine

2:00 Renal Sodium Excretion Consequent to Pharmacogenetic Activation of Gq-DREADD in Principal Cells, E. Mironova, J. Stockand, University of Texas Health Science Center at San Antonio

2:15 New Vibro-Dissociation Method for Isolation of Defined Nephron Segments and Small Renal Vessels, E. Isaeva, M. Fedoriuk, R. Bohovyk, V. Levchenko, O. Palygin, A. Staruschenko, Medical College of Wisconsin and Bogomoletz Institute of Physiology, Ukraine

PROGRAM 2019 | 69

2:30 Esm-1 Protects Mice from Glomerular Macrophage Infiltration and Macroalbuminuria in Diabetic Nephropathy, X. Zheng, L. Higdon, N. Sayed, C. Liu, J. Wu, J. Maltzman, V. Bhalla, Stanford University School of Medicine

2:45 Development of a Glomerular Specific Targeted Nanoparticles for Lupus Nephritis, J. Wei, R. Grabau, J. Zhang, L. Wang, S. Wickline, H. Pan, R. Liu, University of South Florida

304 Cardiovascular Section Young Investigator Competition

Featured Topic MON, 1:30 p.m.-3:00 p.m., Convention Center, W311G

Sponsored By: Cardiovascular Section • Cosponsored By: AJP - Heart and Circulatory Physiology Chair: J. Faulkner · Co-Chair: A. Dorrance

1:30 Endothelial Hba1 Regulates Exercise Fitness in Mice, A.S. Keller, S. Brooks, A. Islam, T.S. I. Keller, A.K. Best, S. Murphy, H.A. Page, M.M. Cortese-Krott, Z. Yan, H. Ackerman, B.E. Isakson, University of Virginia, National Institute of Allergy and Infectious Diseases, National Institutes of Health and Heinrich Heine University of Dusseldorf, Germany

1:45 Sex Differences in the Role of the Endothelial Mineralocorticoid Receptor in Vascular Inflammation in Atherosclerosis, M.E. Moss, Q. Lu, S. Iyer, S. Hyon, S. Rao, D. Engelbertsen, M. Caprio, A. Lichtman, I.Z. Jaffe, Tufts Medical Center, Tufts University School of Medicine, Tufts University School of Graduate Biomedical Sciences, Brigham and Women’s Hospital and IRCCS San Raffaele Pisana, Italy

2:00 Mitochondrial Ultrastructure, Function and Calcium Buffering by Massive Calcium Loading Observed Using Advanced Cryo-Electron Microscopy, High-Resolution Respirometry and Spectrofluorimetry, J.O. Strubbe, J. Schrad, K.N. Parent, J. Conway, J.N. Bazil, Michigan State University and University of Pittsburgh

2:15 β-Hydroxybutyrate Increases Nitric Oxide Synthase Activity in Resistance Arteries from Dahl Salt-Sensitive Rats, C.G. McCarthy, S. Chakraborty, Z. Schreckenberger, C.F. Wenceslau, B. Joe, University of Toledo College of Medicine and Life Sciences

2:30 Passive Heat Therapy Lowers Systolic Blood Pressure and Improves Vascular Endothelial Function in Healthy Older Adults, V.E. Brunt, H.L. Rosenberg, A.E. Bazzoni, K.H. Nguyen, J. Frye, M. Chonchol, C.T. Minson, D.R. Seals, University of Colorado Boulder, University of Colorado Denver and University of Oregon

70 | ANNUAL MEETING


2:45 Extracellular Vesicles from Wistar Kyoto and Spontaneously Hypertensive Rats have Differential Vasodilatory Responses in Resistance Arteries, M.E. Good, L. Musante, S. LaSalvia, R.M. Carey, N.L. Howell, T.H. Le, U. Erdbruegger, B.E. Isakson, University of Virginia

305 Gastrointestinal and Liver Physiology and Disease

Featured Topic MON, 1:30 p.m.-3:00 p.m., Convention Center, W309AB

Sponsored By: GI and Liver Physiology Section • Cosponsored By: AJP - Gastrointestinal and Liver Physiology Chair:N. Zachos · Co-Chair: M. Engevik

1:30 High Intensity Focused Ultrasound Treatment Attenuates Disease Progression in a Mouse Model of Non-Alcoholic Steatohepatitis, T.S. Huerta, A. Devarajan, T. Tsaava, S.S. Chavan, K.J. Tracey, Feinstein Institute for Medical Research, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell and The Elmezzi Graduate School of Molecular Medicine

1:45 Serotonin promotes epithelial restitution through goblet cell mediated secretion of Muc2 and TFF3, M.A. Engevik, A. Chang-Graham, J.M. Hyser, J. Versalovic, Baylor College of Medicine and Texas Children’s Hospital

2:00 HuR Regulates Functions of Paneth Cells in the Intestinal Epithelium by Altering Apical TLR2 Distribution through Control of CNPY3 Expression, L. Xiao, X. Li, J. Cai, H.K. Chung, R.N. Jaladanki, J-Y. Wang, University of Maryland School of Medicine and Baltimore VA Medical Center

2:15 Sprouty2 restricts colonic tuft and goblet cell numbers by repressing epithelial IL-33 expression, M.A. Schumacher, J.J. Hsieh, C.Y. Liu, D. Almohazey, K. Katada, D. Warburton, M.R. Frey, Children’s Hospital Los Angeles and Imam Abdulrahman Bin Faisal University, Saudi Arabia

2:30 Role of Type I Interferon Signaling in Regulating Intestinal γδ IEL Homeostasis and Effector Function, L. Jia, K.L. Edelblum, Rutgers and New Jersey Medical School

2:45 Sonic Hedgehog Acts as a Macrophage Chemoattractant During Gastric Epithelial Regeneration in Response to Injury, J. Chakrabarti, M. Schumacher, A. Engevik, J. Chang, E. Teal, J. Hawkins, M. Helmrath, Y. Zavros, University of Cincinnati, Children’s Hospital, Vanderbilt University and Cincinnati Childrens Hospital and Medical Center

PROGRAM 2019 | 71

306 Therapeutic and Adverse Effects of Pharmacological Agents on Integrative Physiology and Pathophysiology

Featured Topic MON, 1:30 p.m.-3:00 p.m., Convention Center, W311H

Sponsored By: Water and Electrolyte Homeostasis Section Chair: A. S. Loria · Co-Chair: V. Wolf Track: Muscle Metabolism, Ion Channels and Transporters, Neuroscience

1:30 Introduction, Analia Loria, University of Kentucky

1:45 Capsaicin-Induced Stimulation of Sensory Neurons in Adipose Tissue Promotes Increases in Blood Pressure in Mice Exposed to Early Life Stress, C. Dalmasso, J.R. Leachman, S. Mounce, X. Xu, A.S. Loria, University of Kentucky

2:00 A Small Molecule Antagonist of RAGE/DIAPH1 Interaction: Novel Therapeutic Opportunities in Metabolic and Chronic Disease, M.B. Manigrasso, M.G. Spelios, R.A. Friedman, R.J. DeVita, R. Ramasamy, A. Shekhtman, A. M. Schmidt, NYU Langone Health, Columbia University Medical Center, RJD Medicinal Chemistry and Drug Discovery Consulting LLC, University at Albany and State University of New York

2:15 Recombinant Human Relaxin-2 Treatment in an Experimental Female Mouse Model of Autoimmune Disease with Hypertension, V. Wolf, T.L. Phillips, J.M. Sasser, M.J. Ryan, University of Mississippi Medical Center

2:30 Sex-Specific Adverse Effects of Chronic Dichloroacetate Administration in Mice, G. Kararigas, L. Altinbas, C. Noack, L.C. Zelarayan, R. D’Almeida, Charite University Hospital, Germany and Georg-August-University Göttingen, Germany

2:45 Role of the MCP-1/CCR2 Axis in the Development of Dahl Salt-Sensitive (SS) Hypertension and Renal Damage, A. Alsheikh, J. H. Dasinger, H. Lund, J.M. Abais-Battad, J. Zemaj, D. J. Fehrenbach, D. L. Mattson, Medical College of Wisconsin

307 APS Chapters: Why, How, What of Starting New Chapters


Sponsored By: APS Chair: M. Hopper Track: Career Central

72 | ANNUAL MEETING


308 August Krogh Distinguished Lectureship of the APS Comparative and Evolutionary Physiology Section

Lecture MON, 3:30 p.m.-4:30 p.m., Convention Center, W308CD

Sponsored By: Comparative & Evolutionary Physiology Section Supported by: Novo Nordisk Fonden

3:30 On the Cardio-Neural Trail of Stranded Whales and Wounded Warriors: An August Krogh Investigation, Terrie Williams, University of California, Santa Cruz

309 Carl W. Gottschalk Distinguished Lectureship of the APS Renal Section

Lecture MON, 3:30 p.m.-4:30 p.m., Convention Center, W311EF

Sponsored By: Renal Section Track: Cell Signaling, Signal Transduction

3:30 Regulation of Renin Cell Fate in Homeostasis and Disease, R. Ariel Gomez, University of Virginia School of Medicine

310 Horace W. Davenport Distinguished Lectureship of the APS Gastrointestinal and Liver Physiology Section


Sponsored By: GI and Liver Physiology Section

3:30 The Cholangiopathies: Pathogenic Perspectives and Therapeutic Targets, Nicholas LaRusso, Mayo Clinic

311 Joseph Erlanger Distinguished Lectureship of the APS Central Nervous System Section

Lecture MON, 3:30 p.m.-4:30 p.m., Convention Center, W311G

Sponsored By: CNS Section Track: Neuroscience, Cell Signaling, Signal Transduction

3:30 Parental Stress and Germ Cell Epigenetic Contributions to Offspring Development, Tracy Bale, University of Maryland School of Medicine

PROGRAM 2019 | 73

312 Solomon Berson Distinguished Lectureship of the APS Endocrinology and Metabolism Section


Sponsored By: Endocrinology and Metabolism Section Track: Nutrition/Diet, Muscle Metabolism, Cell Signaling, Signal Transduction

3:30 Epigenetic Control and the Circadian Clock: Turning Back Time on Diabetes Pathogenesis, Juleen Zierath, Karolinska Institutet

313 ENaC and Fluid Transport across Airway Epithelia

Symposium MON, 3:30 p.m.-5:00 p.m., Convention Center, W311D

Sponsored By: Respiration Section • Cosponsored By: AJP - Lung Cellular and Molecular Physiology Chair: M. Althaus · Co-Chair: M. Butterworth Track: Ion Channels & Transporters

3:30 Slippery when Wet: SPLUNC1, ENaC and Airway Hydration, Robert Tarran, University of North Carolina

4:00 Protease Inhibitors to Regulate ENaC and Improve Airways Hydration in Cystic Fibrosis, Lorraine Martin, Queen’s University Belfast

4:30 Role of ENaC in Chronic Airway Disease, Johanna Salomon, University of Heidelberg

314 New Frontier in Direct Effects of Lipids and Lipid Metabolic Defects on Membrane Proteins


Sponsored By: Cell and Molecular Physiology Section • Cosponsored By: AJP - Cell Physiology Chair: Q-X. Jiang · Co-Chair: V. Gohil Track: Metabolic Programming/Epigenetics, Ion Channels and Transporters, Cell Signaling, Signal Transduction

3:30 The Effect of Dietary Fatty Acids in Sensory Ion Channels, Valeria Vasquez, University of Tenessee HSC

3:50 Novel Membrane-Protein Interactions in a Mechanosensitive Ion Channel Defined by Cryo-EM, Edwardo Perozo, University of Chicago

74 | ANNUAL MEETING


4:10 Phosphatidylethanolamine Metabolism and Mitochondrial Function, Vishal Gohil, Texas A&M University

4:30 Lipid-Dependent Gating of Voltage-Gated Ion Channels and Its Possible Roles in Lipid-Metabolic Diseases, Qiu-Xing Jiang, University of Florida

315 Cardiac and Peripheral Vasculopathies: Emerging Biomarkers, Imaging and Treatments

Featured Topic MON, 3:30 p.m.-5:00 p.m., Convention Center, W312A

Sponsored By: Cardiovascular Section • Cosponsored By: AJP - Heart and Circulatory Physiology Chair: A. J. LeBlanc · Co-Chair: C. Kaufman

3:30 From Imaging of Calcifying Exosomes to Systems Biology of Calcific Cardiovascular Disorders, Elena Aikawa, Harvard Medical School

4:00 Stress Strain Speckle-Tacking Segmental Analysis Reveals Early Indications of Diastolic Dysfunction in a Type 2 Mouse Model of Diabetes Mellitus, A.J. Durr, Q.A. Hathaway, M.V. Pinti, D.L. Shepherd, A. Kunovac, G.K. Fink, J.M. Hollander, West Virginia University

4:15 Rat VCA Heterotopic Hindlimb Model of Rejection and Vasculopathy in the Presence of Maintenance Immunosuppression, Y. Fleissig, J.E. Beare, R.M. Reed, A.J. LeBlanc, S.K. Williams, J.B. Hoying, C.L. Kaufman, Christine M . Kleinert Institute for Hand and Microsurgery, Cardiovascular Innovation Institute, University of Louisville, Kentucky Spinal Cord Injury Research Center, Department of Physiology and University of Louisville

4:30 Implications of Genetic Manipulation of Caveolin-1 Protein Expression in a Mouse Model of Marfan Syndrome-Associated Aortic Aneurysm, T. Curry, B. Hoxha, N. Johnson, T.L. Broderick, J. Vallejo-Elias, M. Esfandiarei, Midwestern University

4:45 Dietary Glycocalyx Precursor Supplementation Ameliorates Age-Related Vascular Dysfunction, D.R. Machin, D. Nguyen, R.C. Bramwell, L.A. Lesniewski, A.J. Donato, University of Utah and VA Medical Center

316 Emerging Therapeutics for Respiratory Dysfunction

Featured Topic MON, 3:30 p.m.-5:00 p.m., Convention Center, W312B

Sponsored By: Respiration Section • Cosponsored By: AJP - Lung Cellular and Molecular Physiology Chair: D. Falk · Co-Chair: L. Ferreira Track: Ion Channels and Transporters, Neuroscience, Muscle Metabolism

PROGRAM 2019 | 75

3:30 Gene Therapy for the Treatment of Neuromuscular Disease, Barry Byrne, University of Florida

4:00 Respiratory Directed Gene Therapy Prolongs Survival in an ALS Mouse Model, M.K. ElMallah, A. Keeler-Klunk, M. Zieger, A.L. McCall, L. Pucci, R.H. Brown; Jr, C. Mueller, Duke University and University of Massachusetts

4:15 Chronic, Closed-Loop, Cervical Epidural Stimulation Elicits Plasticity in Diaphragm Motor Output and Upregulates Spinal Neurotrophic Factor Gene Expression, E.A. Dale, M.D. Sunshine, M.N. Kelly, G.S. Mitchell, D.D. Fuller, P.J. Reier, University of Florida

4:30 Repetitive Transcranial Magnetic Stimulation (rTMS) Elicits Long Lasting Phrenic Motoneuron Excitability Increase in the Rat: Possible Treatment for Respiratory Insufficiency?, S. Vinit, P. Michel-Flutot, L.V. Zholudeva, M.L. Randelman, A. Mansart, T.B. Deramaudt, M.A. Lane, M. Petitjean, M. Bonay, Université de Versailles Saint Quentin en Yvelines, France, Drexel University, Hôpital Antoine Béclère, Groupe Hospitalier Paris-Sud, France, University Paris-Sud, Université Paris-Saclay, France and Université d’Orléans, France

4:45 Diaphragm Stimulation Enhances Respiratory Function After Cervical Spinal Cord Injury, E.J. Fox, K. Cavka, P. Freeborn, G. Tonuzi, A. Kerwin, C. Croft, B. Yorkgitis, M.D. Sunshine, D. Martin, D.D. Fuller, Brooks Rehabilitation, University of Florida, University of Florida Health Shands Jacksonville and University of Florida Health Science Center

317 Mechanisms Underlying the Greater Propensity for Cardiovascular Disease in Populations with Elevated Risk

Featured Topic MON, 3:30 p.m.-5:00 p.m., Convention Center, W311H

Sponsored By: Environmental and Exercise Physiology Section • Cosponsored By: AJP - Heart and Circulatory Physiology Chair: D. M. Keller · Co-Chair: R. M. Brothers Track: Inflammation/Immunity, Cell Signaling, Signal Transduction

3:30 Racial Disparities in Vk: An Integrative Approach, Matt Brothers, University of Texas at Arlington

4:00 Endothelin A Receptor Blockade Improves Insulin-Stimulated Blood Flow in Patients with Type 2 Diabetes, B.E. Young, J. Padilla, S. Finsen, S.P. Mortensen, P.J. Fadel, University of Texas at Arlington, University of Missouri and University of Southern Denmark, Denmark

4:15 Greater α1 and α

2 Adrenergic Mediated Vasoconstriction in Contracting Skeletal

Muscle of Type 2 Diabetic Human, J. Bock, W. Hughes, K. Ueda, A. Feider, S. Hanada, N. Kruse, E. Iwamoto, D. Casey, University of Iowa and Sapporo Medical University, Japan

76 | ANNUAL MEETING


4:30 Primary Prevention of Age- and Western Diet-Associated Vascular Endothelial Dysfunction by Voluntary Aerobic Exercise in Mice: Role of Mitochondrial Oxidative Stress, Z.S. Clayton, R.A. Gioscia-Ryan, M.J. Rossman, J.J. Richey, L.M. Cuevas, M.L. Battson, M.C. Zigler, D.R. Seals, University of Colorado Boulder

4:45 Inhibition of Nuclear Factor-KappaB Improves Nitric Oxide-Dependent Dilation in the Cutaneous Microvasculature of Psoriatic Adults, B.K. Alba, J.L. Greaney, S.B. Ferguson, L.M. Alexander, The Pennsylvania State University, U .S . Army Research Institute of Environmental Medicine, Oak Ridge Institute of Science and Education and Penn State Hershey Medical Group

318 Wiggers Award Featured Topic

Featured Topic MON, 3:30 p.m.-5:00 p.m., Convention Center, W311C

Sponsored By: Cardiovascular Section • Cosponsored By: AJP - Heart and Circulatory Physiology Chair: S. Chien

3:30 Epigenetic Regulation of Mechanotransduction in Vascular Endothelium, Shu Chien, UCSD

4:00 Endothelin-1 Potentiates Capsaicin-induced Constriction of Human Adipose Arterioles, A.M. Korishettar, Y. Nishijima, D.X. Zhang, Medical College of Wisconsin, The Medical College of Wisconsin and Inc .

4:15 Withdrawn

4:30 The Targeted Inhibition of Neuraminidase Reverses Endothelial Glycocalyx Degradation and Improves Endothelial Function in Type 2 Diabetes, C.A. Foote, T. Ghiarone, F.I. Ramirez-Perez, A.R. Kluser, Z.I. Grunewald, T.J. Jurrissen, S.M. Brown, S.B. Bender, C. Manrique-Acevedo, A.R. Aroor, J. Padilla, L.A. Martinez-Lemus, University of Missouri and Truman VA

4:45 Endothelial Upregulation of Mechanosensitive Channel Piezo1 in Pulmonary Hypertension, Z. Wang, A. Babicheva, L. Wu, J-J. Yuan, J. Wang, University of Arizona and Guangzhou Medical University, People’s Republic of China

319 Environmental and Epigenetic Contributions to Disease Origin

Featured Topic MON, 3:30 p.m.-5:00 p.m., Convention Center, W311B

Sponsored By: Water and Electrolyte Homeostasis Section • Cosponsored By: AJP - Cell Physiology

PROGRAM 2019 | 77

Chair: K. Hyndman · Co-Chair: J. Leachman Track: Nutrition/Diet, Metabolic Programming/Epigenetics, Microbiome

3:30 Maternal and Sex-Specific Fetal Characteristics of Three Different Mouse Models for Fetal Programming by Preeclampsia, T. Plösch, D. J. Dijkstra, V. Stojanovska, R. N. Verkaik-Schakel, S. A. Scherjon, University Medical Center Groningen, Netherlands

3:45 Renal Medullary Histone Deacetylase Dependent Regulation of Fluid-Electrolyte Homeostasis During High Salt Feeding, K.A. Hyndman, J.S. Speed, S. El-Dahr, E. Olson, D.M. Pollock, J.S. Pollock, University of Alabama at Birmingham, University of Mississippi Medical Center, Tulane University School of Medicine and UT SouthWestern Medical Center

4:00 DNA methylation as a mediator of the association between stress and depression: A genome-wide DNA methylation study, S. Su, G. Hao, N.A. Youssef, M. Stefanek, F. Treiber, X. Wang, J. Pollock, G. Harshfield, AU/Medical College of Georgia, AU/College of Science and Mathematics, Medical University of South Carolina and UAB/School of Medicine

4:15 Mice Exposed to Early Life Stress Display Sex-Specific Upregulation of Leptin Gene Expression in Adipose Tissue, J.R. Leachman, M. Rea, C. Ritter, X. Xu, C. Dalmasso, Y. Fondufe-Mittendorf, A.S. Loria, University of Kentucky

4:30 Maternal exercise enhances brown adipose tissue development and thermogenesis in offspring mice challenged with high fat diet, J. S. Son, X. Liu, Y. Chen, Q. Tian, L. Zhao, Y. Hu, S. A. Chae, J. Deavilla, M-J. Zhu, M. Du, Washington State University and University of Idaho

320 APS Investigator Awards Recognition

Award Session MON, 5:15 p.m.-5:40 p.m., Convention Center, W314

Sponsored By: APS

321 Henry Pickering Bowditch Award

Lecture MON, 5:40 p.m.-6:30 p.m., Convention Center, W314

Sponsored By: APS

5:40 Functional Roles for Orphan GPCRs in the Kidney, Jennifer Pluznick, Johns Hopkins University

78 | ANNUAL MEETING

ORAL SESSIONSTUESDAY, APRIL 9

399 Career Planning: No Scientist Left Behind

Symposium TUES, 7:00 a.m.-8:00 a.m., Convention Center, W311C


7:00 Knowing When to Say Yes, Knowing When to Say No: Strategies for Success, Nancy Fjortoft, Midwestern University

400 Marketing Yourself for a Successful Career III

Symposium TUES, 7:00 a.m.-8:00 a.m., Convention Center, W311B


7:00 Capitalizing on Social Networks to Build a Successful Career, Melissa Bates, University of Iowa


Symposium TUES, 7:00 a.m.-8:00 a.m., Convention Center, W311D

Sponsored By: Careers in Physiology Committee Chair: B. Becker· Co-Chair: C. Trimby Track: Career Central

7:00 The Elusive Informal Skills: Things I Wish I Had Known Earlier, Alberto Roca, DiverseScholar

7:30 The Elusive Informal Skills: Things I Wish I Had Known Earlier, Adam Case, University of Nebraska Medical Center

PROGRAM 2019 | 79

402 Crosstalk among Myofibers, Microvessels and Motor Nerves during Skeletal Muscle Regeneration

Symposium TUES, 8:30 a.m.-10:00 a.m., Convention Center, W311EF

Sponsored By: Experimental Biology Symposium Series • Cosponsored By: J . Appl . Physiol . Chair: S. S. Segal

8:30 Interactions Between Myogenic, Vasculogenic and Neuronal Cells During Skeletal Muscle Regeneration, Dawn Cornelison, University of Missouri

9:00 Mechanisms for Forming and Maintaining Neuromuscular Synapses, Steven Burden, New York University

9:30 Engineering Human Skeletal Muscle in a Dish: Defining the Critical Components, Penney Gilbert, University of Toronto

403 Muscle-Derived Extracellular Vesicles in the Regulation of Metabolic Health and Disease

Symposium TUES, 8:30 a.m.-10:00 a.m., Convention Center, W308AB

Sponsored By: Muscle Biology Group Chair: D. Lark Track: Muscle Metabolism

8:30 Fibroblast-Derived Exosomes Regulate Extracellular Matrix Remodeling, Charlotte Peterson Peterson, University of Kentucky

9:00 Exercise Promotes Secretion of Exosomes from Human Skeletal Muscle, Martin Whitham Whitham, Garvan Institute of Medical Research

9:30 Extracellular Vesicles as Signalling Mediators in Diabetes Mellitus, Nicole Hooten, NIA/NIH

80 | ANNUAL MEETING


404 Musculoskeletal Afferents and the Control of Breathing

Symposium TUES, 8:30 a.m.-10:00 a.m., Convention Center, W311H

Sponsored By: Respiration Section • Cosponsored By: AJP - Lung Cellular and Molecular Physiology and J . Appl . Physiol . Chair: K. Streeter · Co-Chair: D. Fuller Track: Muscle Metabolism, Cell Signaling, Signal Transduction

8:30 Diaphragm Afferents and Cardiorespiratory Control, Kristi Streeter, University of Florida

8:50 Reflex Control of Breathing in Humans by Musculoskeletal Afferents, Jane Butler, Neuroscience Research Australia and University of New South Wales

9:10 Role of Muscle Afferents in Determining Fatigue and Exercise Performance, Markus Amman, University of Utah and VA Medical Center, Salt Lake City

9:30 Respiratory and Limb Muscle Metaboreceptors Impact Sympathetic and Respiratory Output during Exercise, Jerome Dempsey, University of Wisconsin

405 Physiology of Obesity: From Mechanisms to Medicine

Symposium TUES, 8:30 a.m.-10:00 a.m., Convention Center, W308CD

Sponsored By: The Physiological Society-UK (PHYSOC) and American Physiological Society (APS) Chair: P. Aldiss · Co-Chair: J. E. Lewis

8:30 The Role of Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Neurons in the Hypothalamus, Alice Adriaenssens, University of Cambridge

9:00 GPAT4, Novel Biology and Therapeutic Potential, Ricardo Samms, Eli Llly and Company

9:30 Hepatic Remote Control of Appetite, Matthew Gillum, University of Copenhagen

PROGRAM 2019 | 81

406 Protein Degradation Mechanisms: A Compartmentalized Affair in Cardiac Muscle and Disease?

Symposium TUES, 8:30 a.m.-10:00 a.m., Convention Center, W309AB

Sponsored By: Cardiovascular Section • Cosponsored By: AJP - Heart and Circulatory Physiology Chair: F. Sheikh · Co-Chair: Y. Liang

8:30 Critical Role of Neddylation in the Developing Heart, Huabo Su, Augusta University

8:50 The Role of Muscle LIM Domain Protein in Protein Quality Control, Katja Gehmlich, University of Oxford

9:10 A Novel Mechanism Impacting Cardiac Desmosomal Cell Junction Protein Degradation and Disease, Farah Sheikh, University of California- San Diego

9:30 Mitophagy Plays an Essential Role in Mediating Protein Quality Control in the Heart, Junichi Sadoshima, University of Medicine and Dentistry of New Jersey

407 Advances in Renal Physiology II

Featured Topic TUES, 8:30 a.m.-10:00 a.m., Convention Center, W311G

Sponsored By: Renal Section • Cosponsored By: AJP - Renal Physiology Chair: A. T. Layton • Co-Chair: J. Sullivan Track: Inflammation/Immunity, Cell Signaling, Signal Transduction, Ion Channels and Transporters

8:30 Sex Differences in the Progression of Type 2 Diabetic Nephropathy, D.R. Spires, D.V. Ilatovskaya, V. Levchenko, J. Bukowy, A. Staruschenko, O. Palygin, Medical College of Wisconsin and Medical University of South Carolina

8:45 Renal Hypertrophic Signaling Triggers Activation of Kidney Immune Response and Accelerates Cystogenesis in Polycystic Kidney Disease, T. Saigusa, J. Huang, L. He, B.K. Yoder, K.A. Zimmerman, P. D. Bell, University of Alabama at Birmingham

9:00 Female Mice are Protected Against the Renal Pro-Inflammatory Effects of a High-Salt Diet During Diabetes, J.F. Giani, A.F. Hernandez, E.A. Bernstein, L.C. Veiras, Z. Khan, D. Cao, Z. Peng, K.E. Bernstein, Cedars-Sinai Medical Center

9:15 Temporally-Induced Nephron Polycystin-1 Knockout Causes Salt and Water Wasting and Reduced Blood Pressure in the Absence of Polycystic Kidney Disease, D. Kohan, J. Lakshmipathi, D. Stuart, N. Ramkumar, Y. Gao, University of Utah

82 | ANNUAL MEETING


9:30 Renal Medullary Interstitial Cell-Specific Knockout of the Endothelin A Receptor Increases Sodium Excretion and Prevents Salt-Sensitive Hypertension, C. Hu, D. Stuart, J. Lakshmipathi, R.C. Harris, C. M. Hao, D.E. Kohan, University of Utah, Vanderbilt University and Fudan University, People’s Republic of China

9:45 Effects of Venous Congestion and Intrarenal Renin-Angiotensin System Activation on Renal Hemodynamics in Rats with High-Output Heart Failure, V. Kratky, Z. Vanourkova, L. Kopkan, Institute for Clinical and Experimental Medicine, Czech Republic, Second Faculty of Medicine and Charles University, Czech Republic

408 Autonomic Function in Normal and Preeclamptic Pregnancies

Featured Topic TUES, 8:30 a.m.-10:00 a.m., Convention Center, W311B

Sponsored By: Neural Control and Autonomic Regulation Section • Cosponsored By: AJP - Heart and Circulatory Physiology Chair: N. Stachenfeld · Co-Chair: C. Usselman

8:30 Sympathetic Neurovascular Function in Postpartum Women Following Preeclamptic Pregnancies, Charlotte Usselman, McGill University

9:00 Sympathetic Transduction in Young Women with a Family History of Hypertension, S.J. McGinty, M.C. Babcock, E.L. Matthews, J.L. Greaney, M.M. Wenner, University of Delaware, Montclair State University and The Pennsylvania State University

9:15 Prior Exposure to Preeclampsia Causes Increased Salt Sensitivity of Blood Pressure at Postpartum through Vasopressin Production and Secretion, K. Shinohara, T. Matsuura, Y. Hirooka, H. Tsutsui, Kyushu University, Japan and International University of Health and Welfare, Japan

9:30 Blood Pressure Variability during Early-Mid Pregnancy in Women Who Develop Preeclampsia: Association with Aortic Stiffness but not Baroreflex Sensitivity, V. Nuckols, S. Holwerda, L. DuBose, A. O’Deen, A. Stroud, R. Luehrs, D. Brandt, M. Santillan, J.L. Grobe, D. Santillan, G. Pierce, University of Iowa

9:45 Cerebral Blood Flow Response to a Sympathoexcitatory Stimulus in Postmenopausal Women with a History of Preeclampsia, K.B. Miller, V.M. Miller, R.E. Harvey, S.M. Ranadive, M.J. Joyner, J.N. Barnes, University of Wisconsin - Madison, Mayo Clinic, University of Minnesota Twin Cities and University of Maryland

PROGRAM 2019 | 83

409 Cardiovascular Metabolism in Diabetes

Featured Topic TUES, 8:30 a.m.-10:00 a.m., Convention Center, W311C

Sponsored By: Cardiovascular Section • Cosponsored By: AJP - Heart and Circulatory Physiology Chair: B. G. Hill · Co-Chair: R. Harmancey

8:30 Molecular Basis of Postischemic Maladaptation in the Insulin Resistant Heart, Romain Harmancey, University of Mississippi Medical Center

9:00 Leptin-induced Endothelial Dysfunction is Mediated by Endothelial Mineralocorticoid Receptor Activation in Premenopausal and Pregnant Females, J.L. Faulkner, S. Kennard, G. Antonova, I.Z. Jaffe, V. Patel, E. J.B. de Chantemele, Medical College of Georgia at Augusta University and Tufts University

9:15 Sex Differences in Type-2 Diabetes: Implications for Caveolin-3 Regulated Mitochondrial Function, A.E. Zemljic-Harpf, A. Ronquillo, M. Dhanani, J.S. Leem, M.P. Thio, B.F. Alas, S. Y. Kim, J.M. Schilling, D.M. Roth, H.H. Patel, Veterans Administration San Diego Healthcare System, and University of California and San Diego

9:30 Endothelial mTORC1 Signaling is Required for Vascular Endothelial Function, J.J. Reho, D-F. Guo, K. Rahmouni, University of Iowa

9:45 Time Course Adaptations in Oxygen Uptake Kinetics During Heavy-Intensity Exercise Initiated from an Elevated Baseline Subsequent to a 12 Week High-Intensity Interval or Moderate-Intensity Continuous Training in Type 2 Diabetes, N. Gildea, A. McDermott, J. Rocha, A. Nevin, D. O’Shea, S. Green, M. Egana, Trinity College Dublin, Ireland, Abertay University, United Kingdom, St Columcille’s and St Vincent’s Hospitals, Ireland and Western Sydney University, Australia

410 Examining Physiological Mechanisms Using Environmental Stressors

Featured Topic TUES, 8:30 a.m.-10:00 a.m., Convention Center, W311D

Sponsored By: Environmental and Exercise Physiology Section • Cosponsored By: J . Appl . Physiol . Chair: B. D. Johnson · Co-Chair: Z. J. Schlader Track: Cell Signaling, Signal Transduction, Inflammation/Immunity

8:30 Hypoxia and the Brain: Mechanistic Insight from Elite Free Divers and High Altitude Native Populations, Philip Ainslie, University of British Columbia Okanagan

84 | ANNUAL MEETING


9:00 Amino Acid-Based Oral Rehydration Solution Mitigates Exertional Heat Stroke Severity but Does Not Alter the Innate Immune Response, M.A. King, S. Dineen, J. Ward, T. Mayer, M. Plamper, A. Grosche, X. Xu, A. Sasidharan, M. Ward, T. Clanton, S. Vidyasagar, L. Leon, USARIEM and University of Florida

9:15 Non-Invasive Pulmonary Gas Exchange Measurements Following Deep Breath-Hold Diving, A. Patrician, I. Drvis, T. Dawkins, B. Otto, G. Coombs, C. Howe, H. Caldwell, N. Janjic, B. Spajic, M. Stembridge, Z. Dujic, P. Ainslie, University British Columbia Okanagan, Canada, University of Split, Croatia, Cardiff Metropolitan University, United Kingdom and University of Novi Sad, Serbia

9:30 Impact of Repeated Local Heat Stress on Skeletal Muscle Structure and Function in Humans, K. Kim, A. Trewin, A.C. Petersen, T.P. Gavin, B.T. Roseguini, Purdue University and Victoria University, Australia

9:45 Global REACH Expedition: Chronic Hypoxia Attenuates α1 Adrenergic-Mediated

Vasoconstriction in Humans: Mechanisms of Chronic-Hypoxic Sympatholysis, C.M. Hearon, A.B. Hansen, G. Moralez, S.A. Romero, B.D. Levine, J.S. Lawley, UT Southwestern Medical Center, University of Innsbruck, Austria and University of North Texas Health Science Center

411 Ion Channels, Solute and Molecular Transporters In Heath and Disease

Featured Topic TUES, 8:30 a.m.-10:00 a.m., Convention Center, W311A

Sponsored By: Cell and Molecular Physiology Section • Cosponsored By: AJP - Cell Physiology, AJP - Lung Cellular and Molecular Physiology and Physiological Reviews Chair: D. Baines · Co-Chair: M. Althaus Track: Ion Channels and Transporters, Cell Signaling, Signal Transduction

8:30 Calcineurin Inhibition Impairs the Function of Neuronal Potassium-Chloride Cotransporter 2, M. Zessin, U. Strauss, R. Deisz, A. Borschewski, M. Schindler, N. Endlich, S. Loyola, J. Pleinis, A. Rodan, T. Giesecke, J. McCormick, R. Mrowka, K. Mutig, Charite - Universitätsmedizin Berlin, Germany, Universitätsmedizin Greifswald, Germany, University of Utah, Oregon Health and Science University and Universitätsklinikum Jena, Germany

8:45 Inhibition of AT2R and BK2R Attenuates the Effect of High K Intake (HK) on Thiazide-Sensitive Na-Cl Cotransporter, D. Zhang, L. Gu, P. Wu, Z. Gao, R. Gu, D. Lin, W. Wang, New York Medical College and Harbin Medical University, People’s Republic of China

9:00 Phosphorylations in the Termini of Mitochondrial Calcium Uniporter Regulate Mitochondrial Calcium Uptake, J. O-Uchi, J.L. Cao, S.M. Adaniya, B. S. Jhun, S. S. Sheu, University of Minnesota, Rhode Island Hospital, Brown University and Thomas Jefferson University

PROGRAM 2019 | 85

9:15 Characterization of a New Dent Disease Mouse Model Carrying a Pathogenic Mutation of ClC-5, I. Sakhi, Y. Bignon, N. Frachon, S. Lourdel, INSERM U1138, France, Sorbonne Université, France, CNRS, France and INSERM U1147, France

9:30 Regulation of Adipogenesis by α1 Na+/K+ ATPase via Its Conserved Caveolin Binding Motif, M. Huang, L. Cai, S. Pierre, Z. Xie, Marshall University Marshall Institute for Interdisciplinary Research

9:45 The TRPP2 (PC2)-Dependent Ion Channel of Renal Primary Cilia also Requires TRPM3, G. Bryant, N. Kleene, B. Siroky, J. Landero-Figueroa, B. Dixon, N. Pachciarz, L. Lu, S. Kleene, University of Cincinnati, Cincinnati Children’s Hospital Medical Center and University of Colorado

412 John Forte Plenary Session

Featured Topic TUES, 8:30 a.m.-10:00 a.m., Convention Center, W312A

Sponsored By: GI and Liver Physiology Section • Cosponsored By: AJP - Gastrointestinal and Liver Physiology Chair: M. Frey

8:30 RGal Increases Intestinal Epithelial Barrier Function in a PKC-Dependent Manner and Drives an Inflammatory Gene Expression Profile, J. Shang, C.H. Baggio, A.M. Nascimento, T.R. Cipriani, W.K. MacNaughton, University of Calgary, Canada, Federal University of Acre, Brazil and Federal University of Paraná, Brazil

8:45 Lymphocytes mediate bone loss induced by gut microbiota repopulation following antibiotic use, N.D. Rios Arce, L. Schaefer, R. Britton, L. McCabe, N. Parameswaran, Michigan State University and Baylor College of Medicine

9:00 10-Week High-Fat Diet Promotes Endotoxemia and Alters Microbial Taxonomy in Male Adolescent Rats, M.S. Crawford, K. Sweazea, Arizona State University

9:15 The Human Primordial Microbiome Hosts Complex Bacterial and Fungal Interkingdom Ecologies that Vary with Gestational Age, K.A. Willis, J.H. Purvis, C.K. Gomes, A.J. Talati, J.F. Pierre, The University of Tennessee Health Science Center

9:30 Lactobacilli -induced Generation of Reactive Oxygen Species via Formyl Peptide Receptor-1 (FPR1) Regulates Intestinal Motility in Mice, B. Chandrasekharan, B. Saeedi, M. A. Alam, S. Srinivasan, M. Tansey, R. Jones, A. Nusrat, A.S. Neish, Emory University, VA Medical Center and University of Michigan

9:45 IGF1-mTORC1 Signaling Drives Intestinal Epithelial Regeneration after Irradiation Injury, Y. Abushukur, N. Bohin, K.P. McGowan, T.M. Keeley, E.A. Carlson, L.C. Samuelson, University of Michigan

86 | ANNUAL MEETING


413 APS-ASPET Presidential Symposia Series: Microbiome. Microbiota in Action: The Gut and Beyond

Symposium TUES, 8:30 a.m.-10:00 a.m., Convention Center, W314

Sponsored By: President’s Symposium Series Chair: L. McCabe · Co-Chair: J. Cui Track: Microbiome

8:30 Microbiota and Wound Recovery, Andrew Neish, Emory University School of Medicine

9:00 Salt-Sensitive Hypertension and the Gut Microbiota, Dominik Mueller, Max-Delbrük-Center for Molecular Medicine, Berlin

9:30 Microbiota and the Nervous System, Elaine Hsiao, UCLA

414 Inflammasome Activation in Diseases of the Lung

Featured Topic TUES, 8:30 a.m.-10:00 a.m., Convention Center, W312B

Sponsored By: Respiration Section • Cosponsored By: AJP - Lung Cellular and Molecular Physiology Chair: C. Waters · Co-Chair: S. Yeligar Track: Inflammation/Immunity, Metabolic Programming/Epigenetics

8:30 Role of Inflammasome Activation in influenza A Virus Infection, Karen Ridge, Northwestern University School of Medicine

9:00 Cigarette Smoke and Pseudomonas Aeruginosa Synergistically Cause ARDS via Impairment of Mitophagic Flux and NLRP3 Inflammasome Activation, Q. Lu, A. White, Z. Wang, E. Chambers, A. Ayala, S. Rounds, X. Wang, Alpert Medical School of Brown University, Providence VA Medical Center and Lifespan-Rhode Island Hospital

9:15 LPS Promotes ASC-Speck Formation In TREK-1-Deficient Macrophages, C.N. Immanuel, B. Teng, B. Dong, E. Gordon, C. Luellen, S. Cormier, E.A. Fitzpatrick, A. Schwingshackl, C.M. Waters, Children’s Hospital of Los Angeles at USC, Le Bonheur Children’s Hospital, University of Tennessee, University Of Kentucky, Louisiana State University and UCLA

9:30 Chronic Alcohol Administration Induces Inflammasome Activation in Mouse Lungs, S. Yeligar, F. Cingolani, J. Li, B. Bedi, R. Sadikot, M. Czaja, Emory University / Atlanta VAMC and Emory University

9:45 Reactive Oxygen Species Activate the NLRP3 Inflammasome in a Model of Lung Transplant, S. Chatterjee, J. Qin Tao, University of Pennsylvania School of Medicine

PROGRAM 2019 | 87

415 History of Physiology Lecture

Lecture TUES, 1:00 p.m.-2:00 p.m., Hyatt, Plaza Intl Ballroom F

Sponsored By: History of Physiology Group • Cosponsored By: Advances in Physiology Education

1:00 Ancel Keys Lambasted at the Faraday Society Meeting of 1937!, James Bassingthwaighte, University of Washington

416 Julius H. Comroe, Jr. Distinguished Lectureship of the APS Respiration Section

Lecture TUES, 1:30 p.m.-2:30 p.m., Hyatt, Convention Center, W308CD

Sponsored By: Respiration Section Track: Cell Signaling, Signal Transduction, Ion Channels and Transporters

1:30 Heme as a Central Mediator of Acute and Chronic Lung Injury, Sadis Matalon, University of Alabama at Birmingham

417 Emerging Roles of the Cytoskeleton in Striated Muscle

Symposium TUES, 1:30 p.m.-3:00 p.m., Convention Center, W311A

Sponsored By: Cell and Molecular Physiology Section Chair: T. Hawke · Co-Chair: C. Perry Track: Metabolic Programming/Epigenetics, Muscle Metabolism, Cell Signaling, Signal Transduction

1:30 Regulating Skeletal Muscle Function through Cytoskeletal Post-Translational Modifications, Anna Kashina, University of Pennsylvania

2:00 Calpain-Driven Cytoskeletal Remodeling: A Master Regulator of Membrane Repair; the Ultimate Example of Rescuer Turning Rogue with Membrane Injury, Sandra Cooper, The Children’s Hospital at Westmead

2:30 Sexual Dimorphism in Cytoskeletal Regulation, Leslie Leinwand, University of Colorado, Boulder

88 | ANNUAL MEETING


418 American Journal of Physiology – Heart and Circulatory Physiology Editors Symposium

Symposium TUES, 1:30 p.m.-3:00 p.m., Convention Center, W308AB

Sponsored By: Cardiovascular Section Chair: I. H. Zucker · Co-Chair: K. Y. DeLeon Pennell

1:30 The Interchange Between Inflammation and Extracellular Matrix in MI Modeling, Merry Lindsey, University of Nebraska Medical Center

1:50 Endothelial Regulation of Human Arterioles: A Study in Nature’s Diversity and Plasticity, David Gutterman, Medical College of Wisconsin

2:10 Subdomain Localization of Sodium Channels in the Cardiac Myocyte: Location Matters, Mario Delmar, New York University

2:30 H2S Actions in the Vasculature: Where Is It Coming from and How Does It Act?, Nancy Kanagy, University of New Mexico

419 Causes and Consequences of Inter-Individual Physiological Variation

Symposium TUES, 1:30 p.m.-3:00 p.m., Convention Center, W312B

Sponsored By: Comparative & Evolutionary Physiology Section Chair: B. Rees

1:30 Polymorphisms with Major Effects on Organismal Traits and Ecological Dynamics, James Marden, Penn State University

1:50 Polygenic Physiological Adaptation: the Consequences of Individual Variation Within and Among Populations, Doug Crawford, University of Miami

2:10 Causes and Consequences of Inter-Individual Variation in Developmental Stress Physiology, Andrea Liebl, University of South Dakota

420 Moving the Needle on Hypertension: What Knowledge is Needed?

Symposium TUES, 1:30 p.m.-3:00 p.m., Convention Center

Sponsored By: ILSI-North America Chair: N. Fukagawa · Co-Chair: B. Wynne

1:30 Gaps in Knowledge about the Role of Sodium and Potassium in Hypertension Regulation, Alicia McDonough, University of Southern California

PROGRAM 2019 | 89

1:50 The Effects of Dietary Sodium on Brain and Blood Vessel Function, William Farquhar, University of Delaware

2:10 A Personalized Precision Medicine Approach to Combat Salt-Sensitive Hypertension: Feasible or Fantasy?, Richard Wainford, Boston University

2:30 Panel Discussion and Debate Including Nutrition Expert

421 Metabolism, Organ Crosstalk, Microbiome and Mechanisms

Symposium TUES, 1:30 p.m.-3:00 p.m., Convention Center, W311EF

Sponsored By: Experimental Biology Symposium Series Chair: J. Sun

1:30 Microbiome in Gut-Brain Axis, Erika Claud, University of Chicago

2:00 Association of Fecal Metabolites with Enteric Neuronal Survival/Impairment and Gastrointestinal Motility Disorders, Shanthi Srinivasan, Emory University School of Medicine

2:30 Pathogenesis, Immunity and the Role of Microbiome/Probiotics in Virus Infections in Humans and Animal Models, Lijuan Yuan, Virginia-Maryland College of Veterinary Medicine

422 Mighty Concepts in Mitochondrial Biology in the Kidney

Symposium TUES, 1:30 p.m.-3:00 p.m., Convention Center, W311G

Sponsored By: Renal Section • Cosponsored By: AJP - Renal Physiology Chair: S. K. Mallipattu · Co-Chair: Y. Li Track: Cell Signaling, Signal Transduction, Metabolic Programming/Epigenetics

1:30 Altered Mitochondrial Metabolism in AKI and CKD, Prabhleen Singh, UCSD

2:00 Role of Mitophagy (Mitochondrial Autophagy) in Kidney Disease, Zheng Dong, Augusta University

2:30 Mitochondrial Function and Biogenesis in AKI, Samir Panikh, Beth Israel Deaconess Medical Center

90 | ANNUAL MEETING


423 Control of Cellular Organelle Function, Metabolism and Injury in Fatty Liver Diseases

Featured Topic TUES, 1:30 p.m.-3:00 p.m., Convention Center, W309AB

Sponsored By: GI and Liver Physiology Section • Cosponsored By: AJP - Gastrointestinal and Liver Physiology Chair: T. Li · Co-Chair: L. Yang

1:30 Role of Bile Acid Receptors FXR and TGR5 in Fatty Liver Disease, John YL. Chiang, Northeastern Ohio Medical University

2:00 Hepatocyte-Specific Deletion of eNOS Impairs Mitochondrial Function and Exacerbates Hepatic Steatosis, R.P. Cunningham, M.P. Moore, G.M. Meers, N. Nguyen, L. Boccardi, V. Jepkemoi, T. Takahashi, R. S. Rector, Harry S Truman Memorial Veterans Medical Center, University of Missouri and Vanderbilt University School of Medicine

2:15 Impairment of Unfolded Protein Response-Mediated Lysosomal Function Contributes to Obesity-Associated Hepatic Insulin Resistance, Z. Zhang, Q. Qian, M. Li, F. Shao, H. Cao, L. Yang, University of Iowa

2:30 Reduced Hepatic Cholesterol Secretion and Augmented Intestinal Cholesterol Absorption Exacerbate the Development of Nonalcoholic Fatty Liver Disease and the Progression from Liver Steatosis to Nonalcoholic Steatohepatitis in Abcg8 Knockout Mice, D.Q. Wang, H.H. Wang, Albert Einstein College of Medicine

2:45 Uric Acid Activates Aldose Reductase and the Polyol Pathway for Endogenous Fructose Production and Fat Accumulation in the Development of Fatty Liver, M.A. Lanaspa, A. Andres-Hernando, R. Johnson, L.G. Sanchez-Lozada, University of Colorado AMC

424 Hormones and Receptors in Homeostatic Control of Physiology and during Allostasis in Pathophysiology

Featured Topic TUES, 1:30 p.m.-3:00 p.m., Convention Center, W311B

Sponsored By: Water and Electrolyte Homeostasis Section Chair: J. Grobe · Co-Chair: K. Balapattabi Track: Metabolic Programming/Epigenetics, Cell Signaling, Signal Transduction, Ion Channels and Transporters

1:30 Deficiency in Pappa2 Expression Reduces Nephron Endowment and Associates with Hypertension and Chronic Kidney Disease in Rats, V. Kumar, C. Yang, T. Kurth, A. Geurts, A.W. Cowley Jr., Medical College of Wisconsin

PROGRAM 2019 | 91

1:45 Activation of G Protein-Coupled Estrogen Receptor 1, with a GPER Agonist, Reduces Blood Pressure in Female Growth-Restricted Rats in Later Life, G.K. Davis, D.R. Bamrick, A.D. Newsome, L.E. Coats, B.T. Alexander, University of Mississippi Medical Center

2:00 ALMS1 Deletion in Rats Causes Hyperleptinemia, Progressive Obesity and Renal Damage, S. Monu, K. King-Medina, A. Jayakumar, P. Ortiz, Henry Ford Health System

2:15 Control of Resting Metabolism by Regulator of G Protein Signaling-2 (Rgs2) in AgRP Neurons, G. Deng, L.L. Morselli, S.A. Sapouckey, J.A. Sebag, K. Rahmouni, K.N. Gibson-Corley, C.D. Sigmund, H. Cui, W.J. Paradee, J.L. Grobe, University of Iowa

2:30 AT1a Stimulation of Tonicity-Responsive Enhancer Binding Protein (TonEBP/NFAT5) Translation through Annexin-A2 May Represent Allostatic Anticipation of Increased Tonicity, M. Hultström, A. Paliege, S. Jönsson, M.B. Agic, J. Melville, T. Skogstrand, M. Fähling, Uppsala University, Sweden, Universitätsklinikum Carl Gustav Carus Dresden, Germany, Universitetet i Bergen, Norway and Charite - Universitätsmedizin Berlin, Germany

2:45 Sex Difference and Hormones in the Regulation of Vasopressin Secretion during Dilutional Hyponatremia, K. Balapattabi, J.T. Little, M.E. Bachelor, R.L. Cunningham, J.T. Cunningham, University of North Texas Health Science Center

425 New Advances in CNS Physiology

Featured Topic TUES, 1:30 p.m.-3:00 p.m., Convention Center, W311C

Sponsored By: CNS Section • Cosponsored By: Journal of Neurophysiology Chair: M. Zarate Track: Neuroscience, Cell Signaling, Signal Transduction

1:30 Sniffer Cells Detect Angiotensin II Release in the Median Preoptic Nucleus in Vitro, J.T. Cunningham, M.E. Bachelor, J. Yuan, G.E. Farmer, University of North Texas Health Science Center

1:45 Inhibition of Microgliosis with Minocycline Attenuates Central Inflammation Driving Gαi2 Protein Dependent Sympathetically Mediated Salt Sensitive Hypertension, J. Moreira, R. Wainford, Boston University

2:00 Microanalytical Mass Spectrometry Detects RAS Metabolites in Small Identified Mouse Brain Samples, C. Lombard-Banek, Z. Yu, A.P. Swiercz, P.J. Marvar, P. Nemes, University of Maryland, College Park and The George Washington University

92 | ANNUAL MEETING


2:15 Primary Cilia of Supraoptic Nucleus Regulate Drinking and Blood pressure, J. Jiang, D. Morgan, K. Rahmouni, University of Iowa Carver College of Medicine

2:30 Peroxynitrite Induces Depolarization and Impairments of Respiration in Isolated Murine Brain Mitochondria, A.L. Albuck, S.S.V.P. Sakamuri, J.A. Sperling, V.N. Sure, S. Zheng, P.V. G. Katakam, Tulane University School of Medicine

2:45 A Subfornical Organ Paraventricular Nucleus Neuronal Network Contributes to Non-Alcoholic Fatty Liver Disease via Hepatic Sympathetic Outflow, K. Blackmore, H. Simonyan, C. Young, George Washington University School of Medicine and Health Sciences

426 Noncoding RNAs: Emerging Functions in Metabolism and Diseases

Featured Topic TUES, 1:30 p.m.-3:00 p.m., Convention Center, W311H

Sponsored By: Endocrinology and Metabolism Section Chair: W. Huang · Co-Chair: Y. Zhang Track: Metabolic Programming/Epigenetics, Nutrition/Diet

1:30 Noncoding RNAs in Diabetes and Liver Disease, Wendong Huang, Beckman Research Institute of City of Hope

2:00 Comprehensive Identification of Micropeptides Encoded by Long Noncoding RNAs in Human Tissues, H. Cao, F. Shao, M. Li, M. Sweat, Q. Qian, Y. Guo, B. Amendt, L. Yang, University of Iowa

2:15 Deletion of miR-92a Results in Glucose Intolerance via Impaired Pancreatic Beta Cell Function, M. T. Islam, T.S. Tippetts, V.R. Gogulamudi, W.L. Holland, S.A. Summers, A.J. Donato, L.A. Lesniewski, University of Utah and Salt Lake City Veterans Affairs Medical Center

2:30 Altered Non-Coding RNA-Histone Acetylation Regulatory Circuit Is Associated With Cognitive Impairment via Gut Dysbiosis in Aging Mice, J. Behera, K. E. Kelly, N. Tyagi, University of Louisville

2:45 An Anoxia-Tolerant Cell Line, AL4, Provides New Insight into Small Non-Coding RNA Biology, C.L. Riggs, J.E. Podrabsky, Saint Louis University and Portland State University

PROGRAM 2019 | 93

427 Regulation of Muscle Sympathetic Outflow during Exercise

Featured Topic TUES, 1:30 p.m.-3:00 p.m., Convention Center, W311D

Sponsored By: Neural Control and Autonomic Regulation Section • Cosponsored By: Journal of Neurophysiology

Chair: J. S. Floras · Co-Chair: P. J. Millar

1:30 Control of Muscle Sympathetic Activity during Acute and Chronic Exercise in Humans With and Without Heart Failure, Catherine Notarius, Sinai Health Systems, Mount Sinai Hospital

2:00 An Exaggerated Muscle Mechanoreflex in Type 2 Diabetic Rats Is Mediated by Potentiated Skeletal Muscle Afferent Discharge to Mechanical Stimulation, R. Ishizawa, H.K. Kim, N. Hotta, G.A. Iwamoto, W. Vongpatanasin, J.H. Mitchell, S.A. Smith, M. Mizuno, University of Texas Southwestern Medical Center and Chubu University, Japan

2:15 Acid-Sensing Ion Channels Blockade Attenuates Pressor and Sympathetic Responses to Skeletal Muscle Metaboreflex Activation in Humans, I.A. Fernandes, M.O. Campos, D.E. Mansur, J. Mattos, A. Paiva, R. Videira, V. Macefield, A.C. Nóbrega, University of Brasília, Brazil, Fluminense Federal University, Brazil and Baker Heart & Diabetes Institute, Australia

2:30 Increased Dietary Salt Augments the Exercise Pressor Reflex, M.C. Babcock, A.T. Robinson, J.C. Watso, K.U. Migdal, M.M. Wenner, S.D. Stocker, W.B. Farquhar, University of Delaware and University of Pittsburg

2:45 Muscle Pump-Induced Inhibition of Sympathetic Vasomotor Outflow during Leg Cycling is Blunted by High-Intensity Muscle Metaboreflex Activation, K. Katayama, T.C. Barbosa, J. Kaur, B.E. Young, O. Shigehiko, P.J. Fadel, Nagoya University, Japan, University of Texas at Arlington and Toyo University, Japan

428 Hot Topics in Hypoxia

Featured Topic TUES, 1:30 p.m.-3:00 p.m., Convention Center, W312A

Sponsored By: Hypoxia Group Chair: N. Nichols

1:30 cAMP-Dependent Modulation of Ih Underlies the P2Y

1 Receptor-Mediated

Excitation of the PreBotzinger Complex Inspiratory Network in Vitro, Y. Zhang, V. Biancardi, A. Miranda Tapia, T.A. Jaib, A. Gourine, S. Kasparov, G.D. Funk, University of Alberta, Canada, University College London, United Kingdom and University of Bristol, United Kingdom

94 | ANNUAL MEETING


1:45 The Hypoxic Ventilatory Response is Blocked by AMPK Deletion in Catecholaminergic, but not Adrenergic Cells, S. MacMillan, A.M. Evans, University of Edinburgh, United Kingdom

2:00 Enhanced Carotid Body Chemosensory Discharge is Essential for the Hypertension Induced by Chronic Intermittent Hypoxia, A. C. Dias, P. Arias, D. Andrade, R. Del Rio, R. Iturriaga, Pontificia Universidad Catolica de Chile, Chile

2:15 Hippocampal Neural Stem Cells Undergo Fate Switch Following Intermittent

Hypoxia, M.A. Khuu, T. Nallamothu, A.J. Garcia, The University of Chicago

2:30 Chronic Intermittent Hypoxia and Hypercapnia Induces Respiratory Insufficiency in an Amyotrophic Lateral Sclerosis Mouse Model, L.M. Strickland, A.L. McCall, L. Pucci, J. Dhindsa, H.L. Tseng, M.K. ElMallah, Duke University

2:45 NIH’s Consortium on Molecular Transducers of Physical Activity (MoTrPAC), J.P. Williams, L. Joseph, MoTrPAC Consortium, NIH

429 The Clinical and Metabolic Benefits of Exercise for People with Type 1 Diabetes

Symposium TUES, 3:30 p.m.-5:00 p.m., Convention Center, W311B

Sponsored By: The Physiological Society-UK (PHYSOC) Chair: A. J. Wagenmakers · Co-Chair: P. Narendran

3:30 Evidence of Early Alterations to Muscle Health in People with Type 1 Diabetes, Cynthia Monaco, McMaster University

3:50 A Multi-Disciplinary Evaluation of Home-Based High-Intensity Interval Training in People with Type 1 Diabetes, Sam Scott, Liverpool John Moores University

4:10 Physical Exercise for Preservation of Beta Cell Function in Patients with Type 1 Diabetes, Parth Narendran, University of Birmingham

4:30 Glucose Management during Training and Half Marathon Running . Results of the EXTOD101 Study, Rob Andrews, University of Exeter Medical School

PROGRAM 2019 | 95

430 Effect of Diet on Metabolism, Cardiovascular and Renal Physiology and Pathophysiology

Featured Topic TUES, 3:30 p.m.-5:00 p.m., Convention Center, W311H

Sponsored By: Water and Electrolyte Homeostasis Section • Cosponsored By: AJP - Renal Physiology Chair: H. Drummond · Co-Chair: P. Pati Track: Metabolic Programming/Epigenetics, Nutrition/Diet, Microbiome

3:30 Sex-Dependent Protection from High Fat Diet-Induced Metabolic Disease in Mice Lacking Degenerin Proteins, H. Drummond, Z. Mitchell, E. Hildebrandt, D.E. Stec, University of Mississippi Medical Center

4:00 Dietary TMAO Exerts Beneficial Effects in Heart Failure Rats, M. Ufnal, T. Huc, A. Drapala, E. Samborowska, M. Konop, Medical University of Warsaw, Poland, Polish Academy of Sciences and Poland

4:15 Western Diet-Induced Metabolic Memory and Persistent Vascular Dysfunction in Female Rats, D. Persand, M. A. C. Sepulveda, New York Institute of Technology College of Osteopathic Medicine

4:30 Restricting food availability to the active period restores rhythmic activation of aortic NOS3 in high fat diet fed mice, P. Pati, D. Zhang, J. Colson, M. Young, S. Bailey, K. Gamble, D.M. Pollock, J.S. Pollock, University of Alabama at Birmingham

4:45 Role of Gut Microbiota and Immunity in the Dietary Modulation of Dahl Salt-Sensitive Hypertension, J.M. Abais-Battad, F.L. Saravia, H. Lund, J. H. Dasinger, D.J. Fehrenbach, A.J. Alsheikh, J. Zemaj, J.R. Kirby, D.L. Mattson, Medical College of Wisconsin

431 Hebert Lecture of the Epithelial Transport Group

Featured Topic TUES, 3:30 p.m.-5:00 p.m., Convention Center, W311C

Sponsored By: Epithelial Transport Group • Cosponsored By: AJP - Cell Physiology Chair: A. McDonough · Co-Chair: M. Kazi Track: Ion Channels and Transporters, Cell Signaling, Signal Transduction

3:30 The Ins and Outs of Protein Trafficking — a Complex Story?, Robert Fenton, Aarhus University

4:00 Imaging of Glomerular Endothelial Cell Calcium Dynamics in Vivo Identifies Endothelial Progenitor Cell Subpopulation, I. M. Schiessl, D. Desposito, A. Izuhara, G. Gyarmati, J. Peti-Peterdi, University of Southern California

96 | ANNUAL MEETING


4:15 In Vivo Effects of Renal Npt2a Inhibition, L. Thomas, J. Xue, J.A. Dominguez Rieg, T. Rieg, University of South Florida

4:30 Inhibition of Protein Phosphatase 1 Prevents High Potassium Mediated Downregulation of the Thiazide-Sensitive Sodium Chloride Cotransporter NCC, M.L. Kortenoeven, Q. Wu, L. Cheng, R.A. Fenton, Aarhus University, Denmark

4:45 Spironolactone Effectively Reduces Renal ENaC Activity and Hypertension in Ang II-Infused Female Rats in a Sex-Specific Manner, V. Buncha, A. Cherezova, E. Gillis, K. Covington, A. McDonough, M. Brands, J. Sullivan, M. Mamenko, Augusta University and The University of Southern California

432 Inflammation and Leukocyte Biology in Cardiovascular Disease

Featured Topic TUES, 3:30 p.m.-5:00 p.m., Convention Center, W312B

Sponsored By: Cardiovascular Section • Cosponsored By: AJP - Heart and Circulatory Physiology and Physiological Reviews Chair: G. V. Halade · Co-Chair: L. E. de Castro Brás

3:30 Adaptive Leukocyte Biology and Non-ischemic Heart Failure, Pilar Alcaide, Sackler School of Graduate Biomedical Sciences

4:00 CD8 T-Cells Regulate Macrophage Recruitment Leading to Exacerbated Cardiac Remodeling, C. Pitts, J. Clayton, K.Y. DeLeon-Pennell, Medical University of South Carolina and Ralph H Johnson VA Medical Center

4:15 Collagen-Derived Matricryptin Reduces Cardiac Dysfunction Post-MI via Integrin Alpha 4, G. Grilo, P. Shaver, R. Iyer, L. de Castro Brás, East Carolina University

4:30 Activation of Formyl Peptide Receptor Precedes the Onset of Hypertension in Dahl Salt Sensitive Rats: Effects of Microbiota and Salt, J. Edwards, S. Galla, C.G. McCarthy, N. Bearss, S. Roy, B. Joe, C.F. Wenceslau, University of Toledo

4:45 The Right Ventricle has More Resident Immune Cells than the Left Ventricle, M.W. Gorr, K. Sriram, A. Muthusamy, A.M. Chinn, P.A. Insel, University of California San Diego

433 Endocrinology and Metabolism Section Trainee and Early Career Awardees Session

Featured Topic TUES, 3:30 p.m.-5:00 p.m., Convention Center, W311A

Sponsored By: Endocrinology and Metabolism Section Chair: D. G. Romero · Co-Chair: L. S. Sidossis

3:30 Endocrinology and Metabolism New Investigator Award . Bilirubin, an Unexpected Metabolic Hormone, Terry Hinds, Jr., University of Toledo

PROGRAM 2019 | 97

4:15 Virendra B . Mahesh Award of Excellence in Endocrinology . Early Inhibition of Angiotensin Converting Enzyme Abolishes the Androgen-Mediated Blood Pressure Increase in a Model of PCOS, Edgar Torres Fernandez, University of Mississippi Medical Center

4:30 Mead Johnson Research Award in Endocrinology . Insulin-dependent Decrease of Excitatory Neurotransmission in Preautonomic PVN Neurons Is Reduced in Diet-induced Obese Mice, Adrien Molinas, Tulane University

4:45 Campbell Award in Endocrinology . Uterine Perivascular Adipose Tissue: A Novel Regulator of Uterine Artery Hemodynamics During Normal Pregnancy, Oluwatobiloba Osikoya, University of North Texas Health Science Center

434 Hot Topics in Neuroscience

Featured Topic TUES, 3:30 p.m.-5:00 p.m., Convention Center, W311D

Sponsored By: APS Neural Control and Autonomic Regulation Section and CNS Section Cosponsored By: Journal of Neurophysiology Chair: C. Banek · Co-Chair: R. Wainford

3:30 Intracellular Chloride Regulation of Supraoptic Vasopressin Neurons during Salt Loading, K. Balapattabi, G.E. Farmer, J.T. Little, M.E. Bachelor, J.T. Cunningham, University of North Texas Health Science Center

3:45 The neural control of arterial pressure by non-catecholaminergic RVLM, B. Holloway, C. Abe, D. Stornetta, R. Stornetta, P. Guyenet, University of Virginia and Gifu University, Japan

4:00 Endothelin B Receptors are Necessary for Appropriate Renal Afferent Nerve Responsiveness, B.K. Becker, U.C. Kopp, D.M. Pollock, University of Alabama at Birmingham and University of Iowa Carver College of Medicine

4:15 Mechanisms Underlying Membrane Androgen Receptor-Induced Neurodegeneration, M.A. A. Tenkorang, P. Duong, E.N. Wilson, R.L. Cunningham, University of North Texas Health Science Center

4:30 Pre-autonomic Corticotropin-Releasing Hormone Neurons in the Paraventricular Nucleus of the Hypothalamus may Contribute to Chronic Unpredictable Stress-Induced Blood Pressure Hyperreactivity, L.A. Wang, S. Cross, S. Mifflin, University of North Texas Health Science Center

4:45 Both Dietary Salt Restriction and Excess Dietary Salt Intake Exaggerate Cardiovascular Reflex Responses to Activation of the Sciatic Afferents, Aortic Depressor Nerve and Vagal Afferents, P.L. Katayama, M.M. Wenner, W.B. Farquhar, K.N. Browning, S.D. Stocker, University of Pittsburgh, University of Delaware and Penn State College of Medicine

98 | ANNUAL MEETING


435 Hot Topics in Nutrition

Featured Topic TUES, 3:30 p.m.-5:00 p.m., Convention Center, W311G

Sponsored By: Nutrition Physiology Interest Group • Cosponsored By: AJP - Gastrointestinal and Liver Physiology Chair: A. Thalacker-Mercer · Co-Chair: E. Borsheim Track: Nutrition/Diet

3:30 Antioxidant Cocktail Acutely Restores Vascular Function After a High Sodium Meal in Males, but not Females, K. Smiljanec, A.U. Mbakwe, M. Ramos Gonzalez, S.L. Lennon, University of Delaware

3:45 Vascular Function in Healthy Adults Consuming Vegetarian and Omnivore Diets, M. Ramos Gonzalez, A.U. Mbakwe, K. Smiljanec, M. Zuelch, M. Witman, S.L. Lennon, University of Delaware

4:00 Effects of 6-weeks of Time-Restricted Feeding in Normal Weight Middle-Aged and Older Adults, E.E. Nagy, M.J. Rossman, M.R. Mazzo, B.A. Denman, L.R. Jankowski, J.J. Richey, S.A. Johnson, Y. Wang, C.M. Peterson, M.B. Chonchol, D.R. Seals, C.R. Martens, University of Colorado, Colorado State University, University of Colorado School of Public Health, University of Alabama, University of Colorado Anschutz Medical Campus and University of Delaware

4:15 The Essentiality of Serine and Glycine for Skeletal Muscle Regeneration, A. Thalacker-Mercer, J. Blum, B. Gheller, Cornell University

4:30 Metabolic Consequences of Exposure to Maternal High Fat Diet in Offspring, K.M. Thakali, B.D. Piccolo, J.D. Sikes, E.C. Wahl, K. Shankar, Arkansas Children’s Nutrition Center and University of Arkansas for Medical Sciences

4:45 The Preterm Infant Gut Microbiome, Human Milk Volume and Immunobiology and Growth, M. Groer, S.V. Dutra, E. Miller, A. Yee, J. Gilbert, University of South Florida and University of Chicago

PROGRAM 2019 | 99

436 APS Trainee Awards Recognition

Award Session TUES, 5:15 p.m.-5:40 p.m., Convention Center, W314

Sponsored By: APS

437 APS Nobel Prize Award Lecture

Lecture TUES, 5:40 p.m.-6:30 p.m., Convention Center, W314

Sponsored By: APS

5:40 Aquaporin Water Channels - From Atomic Structure to Malaria, Peter Agre, Johns Hopkins Malaria Research Institute and Bloomberg School of Public Health

100 | ANNUAL MEETING

Session # Session Title Board Range517 Angiogenesis/Microvascular Remodeling/Injury & Repair C189 C198

518 Microvascular Development and Aging C199 C208

519 Pericytes and Stem Cells C209 C211

520 Lymphatic Function C212 C213

521 Microvascular Mechanics/Hemodynamics/Rheology C214 C217

522 Atherosclerosis/Thrombosis/Platelets C218 C227

523 Inflammation/Leukocyte-Endothelium Interactions C228 C235

524 Ischemia-Reperfusion/Free Radical Biology C236 C241

525 Instrumentation, Methodology and Experimental Models C242 C248

526 Cell Physiology: Emerging Topics, Concepts And Methods C249 C253

527 Endothelial Cell Biology in Health and Disease C254 C274

528 Cerebral Circulation I C275 C287

529 Blood-Brain Barrier, Blood Flow and Metabolism C288 C289

530 Cardiac ECM Niche in Health and Disease C290 C293

531 Cardiac Function and Dynamics C294 C314

532 Heart Failure C315 C333

533 Blood Pressure Regulation I C334 C349

534 Acute Exercise Responses C350 C359

535 Cardiac Responses to Exercise C360 C368

536 Exercise, Health and Disease C369 C388

537 Muscle Plasticity and Gene Regulation/Expression C389 C397

538 Regulation of Muscle Contraction; Fatigue and EC Coupling C398 C403

539 Aging and Nutritional Regulation of Muscle Atrophy; Sarcopenia and Muscle Regeneration

C404 C412

540 Neural Control of the Circulation During Exercise C413 C425

541 Vascular Responses to Exercise and Environmental Stress C426 C446

542 Inflammation: Cellular Responses C448 C470

543 Oxidative Stress, Redox Changes and Mitochondrial Metabolism C471 C486

544 pH Homeostasis and Acid-Base Transport C487 C509

545 Scholander Award Poster Session C510 C518

546 Control of Breathing: Connectivity, Neuromodulation and Neurotransmission

C519 C529

547 Control of Breathing: Integrated Responses C530 C544

POSTER SESSIONS:SUNDAY, APRIL 7 • 9:00 AM-4:00 PM

PROGRAM 2019 | 101

Session # Session Title Board Range548 Control of Breathing: Rhythm Generation and Patterning C545 C551

549 Lung Physiology: Inflammasome Activation in Lung Disease C552 C559

550 Lung Physiology: Pulmonary Hypertension D1 D14

551 Hypoxia: Molecular, Cellular and Integrated Physiology D15 D38

552 Hypoxia: Cellular Responses D40 D42

553 Central Regulation of Food Intake D43 D46

554 Neuroendocrinology/Neuroinflammation D47 D55

555 Neuroendocrinology, hypothalamus and pituitary D56 D58

556 Neuroexcitability, Neurotransmission and Neuroplasticity D59 D66

557 Neuroinflammation/Neuroprotection/Ischemia D67 D78

558 Arterial Baroreflex Function and Blood Pressure Regulation D79 D87

559 Autonomic Circuitry in Thermoregulation or Metabolism D88 D93

560 Chemoreflex Function and Autonomic Regulation D94 D100

561 Differences in Autonomic Regulation in Aging or Sex D101 D109

562 Sympathetic Control of the Circulation D110 D122

563 Sympathetic Regulation in Diabetes and Obesity D123 D126

564 Sympathetic Regulation in Heart Failure D127 D131

565 Sympathetic Regulation in Hypertension D132 D139

566 Acute Kidney Injury D140 E149

567 Diabetic Kidney Disease D150 D167

568 Hormone and Autacoid Effects on the Kidney D168 D170

569 Kidney in Hypertension D171 D190

570 Nutrition, Exercise and Metabolic Syndrome in Renal Function E539 E541

571 Omics and Systems Biology of Renal Function and Disease E542 E545

572 Oxidative Stress and Hypoxia in the Kidney E546 E550

573 Renal Injury and Dysfunction in Pathophysiology E551 E559

574 Therapeutic and Adverse Effects of Pharmacological Agents on Integrative Physiology and Pathophysiology

E560 E570

575 Epithelial Transport Group I E571 E590

576 Renin-Angiotensin System: Genes and Function E591 E595

577 Cardiovascular Endocrinology, Including Renin-Angiotensin-Aldosterone

E596 E601

SUNDAY, APRIL 7 CONTINUED


Session # Session Title Board Range

578 Gestation, Fetal and Neonatal Biology, Including Mammary Gland and Lactation

E602 E607

579 Mitochondrial Function in Endocrinology and Metabolism E608 E610

580 Reproduction and Sex Hormones E611 E617

581 Stress and Trauma Including Adrenal Gland E618 E620

582 Alcoholic and Nonalcoholic Fatty Liver Diseases E621 E629

583 Effects of Diet on GI and Liver Physiology E630 E636

584 Gastrointestinal Nutrient Sensors E637 E638

585 GI Hormones, Peptides and Receptors E639 E641

586 Immunology and Microbiology of the Gut E642 E642

587 Nutrient Metabolism in the Gut E643 E646

588 Pancreatic Physiology and Pathophysiology E647 E647

589 Prebiotics, Probiotics and Gut Function E648 E654

590 Hot Topics in Nutrition E655 E660

591 Metabolic Programming and Nutrition E661 E663

592 Caloric Restriction, High Fat Diets & Dietary Supplements E664 E676

593 Environment, Exercise and Epigenetics in Pathophysiology E677 E691

594 Genetics/Genomics of Exercise, Obesity and Diabetes E692 E693

595 Genetics, Genomics, Transcriptomics, Gene Expression and Epigenetics

E694 E701

596 Genetics/Genomics of Cardiovascular and Kidney Disease E702 E704

597 Genetically-Engineered Model Organisms E705 E706

598 Teaching, Learning and Testing in The Biological and Biomedical Sciences

E707 E733

599 Systems Biology, Computational Modeling and Bioinformatics E734 E734

600 Mathematical Models of Organ Systems, Tissues or Cells E735 E744

601 Mechanobiology E745 E748

602 Regenerative Medicine E749 E753

603 Tissue Engineering E754 E758

SUNDAY, APRIL 7 CONTINUED

PROGRAM 2019 | 103

Session # Session Title Board Range682 Microvascular Cell Signaling Pathways C190 C197

683 Vasomotor Control: Endothelium/Smooth Muscle/Nerves C198 C202

684 Microvascular Flow Regulation/Oxygen Delivery/Networks C203 C220

685 Microvascular Pathophysiology-Pharmacology, Therapeutics and Translational Aspects

C221 C236

686 Permeability/Fluid and Solute Exchange/Glycocalyx C237 C241

687 Tissue-Microvessel Interactions/Extracellular Matrix C242 C242

688 Cerebral Circulation II C243 C260

689 Coronary Circulation C261 C265

690 Myocardial Ischemia C266 C277

691 Blood Pressure Regulation II C278 C291

692 Hypertension I C292 C307

693 Aging, Exercise and Heart Failure: Common Connections and New Targets

C308 C326

694 Diabetes, Insulin Resistance and Obesity I C327 C344

695 Exercise Training Responses C345 C359

696 Mechanisms Underlying the Greater Propensity for Cardiovascular Disease in Population with Elevated Risk

C360 C388

697 Metabolism and Energetics C389 C395

698 Exercise, Muscle Protein Synthesis and Bone Metabolism C396 C396

699 Modulation of Systemic and Tissue Metabolism via Differences in Activity and Fitness

C397 C406

700 Muscle Atrophy and Hypertophy C407 C431

701 Hot Topics in Muscle Biology C432 C447

702 Responses of Bone and Connective Tissue to Exercise and Inactivity

C448 C452

703 Apoptosis, Cell Stress and Cell Death C453 C459

704 Cancer Proliferation and Metastasis: Cell and Molecular Processes

C460 C466

705 Stem Cells, Cell Growth, Development, Differentiation And Autophagy

C467 C474

706 Cell Migration, Adhesion, Contractility and Excitability C475 C478

707 Cell Volume Regulation C479 C483

708 Choroid Plexus and Blood Brain Barrier C484 C487

POSTER SESSIONS:MONDAY, APRIL 8 • 9:00 AM-4:00 PM


Session # Session Title Board Range709 Endothelial and Epithelial Barrier Function C488 C495

710 GI and Liver Epithelial Junctions C496 C497

711 Barrier Function and Repair C498 C501

712 Extracellular Matrix and Cytoskeleton C502 C504

713 microRNAs in Health and Disease C505 C511

714 Noncoding RNAs: Emerging Functions in Metabolism and Diseases

C512 C516

715 Noncoding RNA: miRNA, siRNA and Long ncRNA C517 C518

716 Exosomes, Ectosomes and Microvesicles C519 C523

717 Protein Trafficking, Targeting, Membrane Domains and Cell Polarity

C524 C526

718 Orai and STIM Proteins in Calcium Signaling C527 C527

719 Molecular Mechanisms of Cellular Signaling and Transduction C528 C544

720 Microbiome Influences on Cell Signaling C545 C547

721 Nutritional Influences on Cell Signaling C548 C552

722 Nutrient Regulation of the Microbiome C553 C554

723 Microbes and Nutrition C555 C557

724 Microbiome of the GI tract C558 C565

725 Comparative and Evolutionary Physiology C566 C570

726 Comparative Section Cardiovascular Respiratory Physiology D1 D10

727 Comparative Section Neurobiology D11 D16

728 Comparative Section Osmoregulation D17 D19

729 Comparative Section Osmoregulation Endocrine and Metabolic Physiology

D20 D24

730 Control of Breathing Featured Topic: Perinatal Reprogramming of Respiratory Control

D25 D31

731 Control of Breathing: Respiratory Plasticity D32 D46

732 Control of Breathing: Development D47 D49

733 Control of Breathing: Chemoreception D50 D57

734 Lung Physiology: Airway Epithelia, Smooth Muscle Cell Biology and Asthma

D58 D73

735 Lung Physiology: Sex and Gender in Respiratory Physiology D74 D82

736 Astrocyte and Neuroglial Interactions D83 D86

737 Brain Development and Aging D87 D93

MONDAY, APRIL 8 CONTINUED

PROGRAM 2019 | 105

Session # Session Title Board Range738 Cognition and Behavior D94 D114

739 Effects of Diet on Emotion and Behavior D115 D117

740 Autonomic Anti-inflammatory Mechanisms: Which Branch Trumps?

D118 D124

741 Autonomic Balance: Sympathetic and Parasympathetic D125 D128

742 Central Regulation of Autonomic Control: Brain Stem D129 D139

743 Central Regulation of Autonomic Control: CNS D140 D143

744 Central Regulation of Autonomic Control: Hypothalamus D144 D151

745 NCAR Young Investigators D152 D171

746 Sympathetic and Parasympathetic Regulation in Disease D172 D178

747 Renal Complications of Polycystic Disease D179 D181

748 Renal Hemodynamics, Glomerular Filtration and the Renal Vasculature

E539 E552

749 Renal Pathology, Toxicology E553 E561

750 Renal Water Transport, Urea Transport and Countercurrent Mechanisms

E562 E565

751 Epithelial Transport Group II E566 E587

752 Adipocyte Function and Metabolism E588 E598

753 Obesity and Satiety E599 E609

754 Dietary Regulation of Body Composition E610 E614

755 Macronutrient (Protein, Carbohydrates and Lipids) Regulation of Health and Chronic Disease

E615 E620

756 Pancreatic Hormones and Diabetes E621 E622

757 Sex Specific Differences in Obesity Induced Hypertension E623 E626

758 Sex Differences in Fluid Homeostasis and Blood Pressure Control

E627 E638

759 Translational Endocrinology and Metabolism E639 E641

760 Gastric Physiology and Pathophysiology E642 E643

761 Gastrointestinal Cancer and Metastasis E644 E645

762 Gastrointestinal Development E646 E646

763 Gastrointestinal Motility E647 E652

764 Intestinal Inflammation and Pathophysiology E653 E660

765 Liver Physiology and Pathophysiology E661 E670

766 Teaching, Learning and Testing in The Biological and Biomedical Sciences

E671 E700

MONDAY, APRIL 8 CONTINUED


Session # Session Title Board Range823 Aquaporins and Other Water Transporters C189 C193

824 Ion Channels, Solute and Molecular Transporters and Pumps in Health and Disease

C194 C221

825 Metal Ion Transport C222 C224

826 Nutrient and Metabolite Transporters C225 C226

827 Vascular Ion Channels C227 C240

828 Cardiac and Peripheral Vasculopathies: Emerging biomarkers, Imaging and Treatments

C241 C259

829 Cardiovascular Section Young Investigators (Postdoctoral Trainees)

C260 C269

830 Cardiovascular Metabolism in Diabetes C270 C280

831 Cardiac Muscle; Physiology, Pathology and Metabolism in Health and Disease

C281 C287

832 Cardiovascular Section Young Investigators (Predoctoral Trainees)

C288 C295

833 Cardioprotection C296 C316

834 Diabetes, Insulin Resistance and Obesity II C317 C334

835 Hypertension II C335 C353

836 Inflammation and Leukocyte Biology in Cardiovascular Disease C354 C364

837 Smooth Muscle; Physiology, Pathology and Metabolism in Health and Disease

C365 C369

838 Examining Physiological Mechanisms Using Enviromental Stressors

C370 C399

839 Exercise and Nutrition C400 C406

840 Fluid Balance, Blood Volume Regulation and Trauma C407 C411

841 Respiratory and Altitude: Responses to Exercise C412 C419

842 Temperature Regulation and Biological Timekeeping C420 C433

843 Control of Breathing Featured Topic: Emerging Therapeutics for Respiratory Dysfunction

C434 C446

844 Control of Breathing: Respiratory Motoneurons and Muscles C447 C461

845 Lung Physiology: Endothelial and Vascular Smooth Muscle Cell Biology

C462 C475

846 Lung Physiology: Injury, Repair and Fluid Balance C476 C485

847 Lung Physiology: Mapping The Lung To Better Understand Pulmonary Disease

C486 C491

POSTER SESSIONS:TUESDAY, APRIL 9 • 9:00 AM-4:00 PM

PROGRAM 2019 | 107

Session # Session Title Board Range848 CNS Other C492 C496

849 Neurotransmission and Signaling Molecules C497 D499

850 New Advances in CNS Physiology C500 C515

851 Central Regulation of Body Fluid Homeostasis C516 C518

852 Autonomic Adjustments to Behavioral Stress C519 C522

853 Autonomic Adjustments to Exercise C523 C525

854 Autonomic and Respiratory Interactions C526 C533

855 Autonomic Control of Cerebral and Coronary Blood Flow C534 C536

856 Autonomic Function in Normal and Preeclamptic Pregnancies C537 C539

857 Autonomic Regulation of Neuroendocrine and Fluid Volume C540 C540

858 Enteric Nervous System, Digestion and Metabolic Function C541 C541

859 Inflammation, Immune System and Autonomic Regulation C542 C550

860 Regulation of Muscle Sympathetic Outflow during Exercise C551 C562

861 Immune Cells and Inflammation Impact on Kidney Function and Hypertension

C563 C564

862 Renal Ion Transport, Transporter Regulation and Trafficking D1 D37

863 Renal Translational Physiology D38 E50

864 Sex Differences in Renal Function and Disease D51 D64

865 Preeclampsia and Hypertensive Disorders of Pregnancy D65 D82

866 Dietary Sodium and Pathophysiology D83 D91

867 Hormones and Receptors in Homeostatic Control of Physiology and during Allostasis in Pathophysiology

D92 D100

868 Skeletal Muscle; Physiology, Pathology and Metabolism in Health and Disease

D101 D134

869 GI and Liver Physiology and Disease D135 D163

870 Nutrition and Nutrient Metabolism, Including Lipids, Amino Acids and Carbohydrates

D164 D171

871 Micronutrient (Vitamins and Minerals) Regulation of Health and Chronic Disease

D172 D182

872 The Role of Bioactive Components in Health D183 D186

TUESDAY, APRIL 9 CONTINUED


Session Title Board RangeTeaching of Physiology E539 E540

Comparative and Evolutionary Physiology E541 E544

Translational Physiology E545 E551

Sex Differences in Physiology E552 E557

Biomedical Engineering E558 E558

Environmental and Exercise Physiology E559 E576

Microcirculation E577 E586

Cardiovascular Physiology E587 E648

Water and Electrolyte Homeostasis E649 E654

Renal Physiology E655 E668

Gastrointestinal and Liver Physiology E669 E677

Nutrition Physiology E678 E689

Endocrinology and Metabolism Physiology E690 E701

Respiration Physiology E702 E714

Hypoxia E715 E720

Cell and Molecular Physiology E721 E739

Epithelial Transport E740 E740

Central Nervous System E741 E749

Neural Control and Autonomic Regulation E750 E770

Physiological Genomics E771 E771

Muscle Biology E772 E786

LATE-BREAKING POSTER SESSIONS:TUESDAY, APRIL 9 • 9:00 AM-4:00 PM

PROGRAM 2019 | 109

THURSDAY, APRIL 4

APS Council Meeting (By Invitation Only)6:00 AM-5:30 PM, Hyatt, Orlando Ballroom N

APS Committees Breakfast Room (By Invitation Only)7:00 AM-8:00 AM, Hyatt, Discovery 43

FRIDAY, APRIL 5

NCCC210 Annual Meeting (By Invitation Only)8:30 AM-5:00 PM, Hyatt, Orlando Ballroom M

APS Section Advisory Committee Meeting (By Invitation Only)1:00 PM-6:00 PM, Hyatt, Discovery 46

APS Joint Council/Section Advisory Committee Meeting (By Invitation Only)7:00 PM-10:00 PM, Hyatt, Orlando Ballroom N

SATURDAY, APRIL 6

Joint Program Committee Meeting - Saturday (By Invitation Only)7:30 AM-12:00 PM, Hyatt, Plaza Intl Ballroom F

APS Committee on Committee Meeting (By Invitation Only)8:00 AM-11:00 AM, Hyatt, Discovery 46

APS Physiological Genomics Editor Retreat (By Invitation Only)8:00 AM-12:00 PM, Hyatt, Discovery 45

Animal Care and Experimentation Committee Meeting (By Invitation Only)8:30 AM-11:00 AM, Hyatt Orlando, Ballroom N

APS Council/TPS Meeting (By Invitation Only)10:30 AM-1:30 PM, Hyatt, Plaza Intl Ballroom I

APS NCAR Steering Committee Meeting (By Invitation Only)11:00 AM-1:00 PM, Hyatt, Discovery 47

APS NCAR Section Steering Committee (By Invitation Only)11:00 AM-1:00 PM, Hyatt, Discovery 47

APS Water & Electrolyte Homeostasis Steering Committee Meeting (By Invitation Only)11:00 AM-2:00 PM, Hyatt, Florida Ballroom A

SPECIAL EVENTS:


APS Renal Section Steering Committee (By Invitation Only)12:00 PM-1:00 PM, Hyatt, Orlando Ballroom N

APS Teaching of Physiology Section Steering Committee Meeting (By Invitation Only)12:00 PM-2:00 PM

APS CaMPS Steering Committee Meeting (By Invitation Only)2:30 PM-4:30 PM, Hyatt, Florida Ballroom C

APS Frontiers in Physiology Research Community Leaders Orientation (By Invitation Only)2:30 PM-5:00 PM, Hyatt, Discovery 44

APS/Martin Frank Diversity Travel Award Orientation & Porter Reception (By Invitation Only)3:00 PM-5:00 PM, Hyatt, Orlando Ballroom M

APS Undergraduate Orientation (By Invitation Only)3:00 PM-5:00 PM, Hyatt, Plaza Intl Ballroom JK

APS Physiological Omics Group Reception5:00 PM-6:30 PM, OCCC, W311H

52nd Non-annual Control of Respiration Mixer - 20195:00 PM-8:30 PM, Hyatt, Plaza Intl Ballroom D

SUNDAY, APRIL 7

APS Editorial Board Meeting (Main group and breakout session 1) (By Invitation Only)7:00 AM-8:30 AM, Hyatt, Plaza Intl Ballroom D

APS Physiology Understanding Week Poster Session7:00 AM-9:00 AM, Convention Center, Valencia Ballroom C

APS Hugh Davson-Trainee Breakfast/Poster Blitz (By Invitation Only)7:00 AM-10:00 AM, Hyatt, Florida Ballroom A

AJP-Cell Physiology Editorial Board Meeting APS Horwitz/Horowitz Award Poster Judging (By Invitation Only)7:30 AM-8:30 AM, Hyatt, Rock Spring

APS Editorial Boards Meeting Breakout 3 (By Invitation Only)7:30 AM-8:30 AM, Hyatt, Plaza Intl Ballroom F

APS GI & Liver Meet-the-Experts Breakfast (By Invitation Only)7:30 AM-8:30 AM, Hyatt, Coral Spring

APS Physiological Reports Editorial Board Meeting (By Invitation Only)7:30 AM-9:30 AM, Hyatt, Peacock Springs

SPECIAL EVENTS:SATURDAY, APRIL 6

PROGRAM 2019 | 111

APS Respiration Section Trainee Highlights Breakfast7:30 AM-10:00 AM, Hyatt, Plaza Intl Ballroom JK

APS Environmental & Exercise Physiology Section Adolph Lecturer and Trainee Luncheon (By Invitation Only)12:00 PM-1:00 PM, Hyatt, Plaza Intl Ballroom I

GIL Section Programming Committee Meeting (By Invitation Only)12:00 PM-1:00 PM, Hyatt, Discovery 45

APS Water & Electrolyte Homeostasis Section Luncheon (Advance Ticket Purchase Required)12:00 PM-2:00 PM, Cuba Libre Restaurant & Rum Bar, 9101 Intl Drive

Translational Physiology Interest Group Steering Committee annual meeting (By Invitation Only)12:00 PM-2:00 PM, Hyatt, Discovery 46

APS Science Policy Committee Meeting (By Invitation Only)12:00 PM-2:00 PM, Hyatt, Coral Spring

APS Communications Committee Meeting (By Invitation Only)12:30 PM-2:00 PM, Hyatt, Challenger Breakout 39

APS Medical Physiology Course Directors Meeting2:00 PM-3:30 PM, Hyatt, Barrel Spring II

APS Renal Section Posters & Professors 6:30 PM-8:00 PM, Hyatt, Orlando MN

APS Physiologists in Industry Mixer6:45 PM-8:00 PM, Hyatt, Peacock Springs

Experimental Biology Christian Fellowship7:00 PM-9:00 PM, Hyatt, Rock Spring

APS Publications Committee Banquet (By Invitation Only)7:00 PM-11:00 PM, Hyatt, Florida Ballroom

SPECIAL EVENTS:SUNDAY, APRIL 7


APS Conference Committee (By Invitation Only)7:00 AM-8:30 AM, Hyatt, Discovery 44

APS Membership and FAPS Committee Meeting (By Invitation Only)7:00 AM-10:00 AM, Hyatt, Coral Spring

APS Book Committee Meeting (By Invitation Only)7:30 AM-9:00 AM, Hyatt, Discovery 48

MCS International Liaison Committee for Microcirculation8:00 AM-10:00 AM, Hyatt, Discovery 45

APS CNS Section TAC Breakfast (By Invitation Only)8:30 AM-10:00 AM, Hyatt, Barrel Spring II

Comparative and Evolutionary Physiology Steering Committee (By Invitation Only)8:30 AM-10:30 AM, Hyatt, Manatee Spring 1

APS Physiology Workshop for Life Science Teachers 8:30 AM-3:00 PM, Hyatt, Rock Spring

APS Physiology Joint Managing Board Meeting (By Invitation Only)10:00 AM-11:30 AM, Hyatt, Discovery 44

APS Physiological Omics Group Luncheon and Awards Ceremony (Advance Ticket Purchase Required)12:00 PM-1:30 PM, The Pub Orlando, 9101 Intl Drive

APS/Martin Frank Diversity Travel Award Networking Lunch (By Invitation Only)12:00 PM-1:30 PM, Hyatt, Plaza Intl Ballroom J

APS Sex/Gender Research Interest Group Steering Committee Meeting (By Invitation Only)12:00 PM-1:30 PM, Hyatt, Discovery 48

National Directors of Graduate Studies Meeting12:00 PM-1:30 PM, Hyatt, Barrel Spring I

APS GI & Liver Physiology Section Steering Committee Meeting (By Invitation Only)12:00 PM-1:00 PM, Hyatt, Discovery 47

APS Teaching of Physiology Section - Roundtable Box Luncheon12:00 PM-1:00 PM, Hyatt, Orlando Ballroom M

Chapter Advisory Committee Meeting (By Invitation Only)12:00 PM-2:00 PM, Hyatt, Orlando Ballroom L

APS Early Career Advocacy Fellowship Luncheon12:00 PM-2:00 PM, Hyatt, Peacock Springs

SPECIAL EVENTS:MONDAY, APRIL 8

PROGRAM 2019 | 113

APS Trainee Advisory Committee Meeting (By Invitation Only)12:15 PM-1:15 PM, Hyatt, Manatee Spring 1

APS Awards Committee Meeting (By Invitation Only)12:30 PM-1:30 PM, Hyatt, Orlando Ballroom N

APS Physiology Majors Interest Group Networking Discussion (P-MIG)2:00 PM-3:30 PM, Hyatt, Plaza Intl . Ballroom I

APS International Physiology Committee Meeting (By Invitation Only)2:00 PM-4:00 PM, Hyatt, Coral Spring

APS Teaching of Physiology Section Trainee Networking Session4:00 PM-5:00 PM, Hyatt, Manatee Spring 1

APS Association of Chairs of Department of Physiology ACDP Meeting (By Invitation Only)4:30 PM-5:30 PM, Hyatt, Peacock Springs

APS Environmental & Exercise Physiology Section Business and Awards Meeting5:00 PM-8:00 PM, Hyatt, Plaza Intl Ballroom F

APS Teaching of Physiology Section Business Meeting5:30 PM-7:00 PM, Hyatt, Rock Spring

APS Respiration Section Banquet and Party (Advance Ticket Purchase Required)6:00 PM-7:00 PM, 9101 Intl Drive APS CNS Section Social Event6:00 PM-8:00 PM, Hyatt, Plaza Intl Ballroom K

APS Cardiovascular Section Banquet (Advance Ticket Purchase Required)6:00 PM-10:00 PM, BB King's Blues Club, 9101 Intl Drive

APS Renal Section Banquet (Advance Ticket Purchase Required)6:00 PM-10:00 PM, Lafayette's Restaurant, 9101 Intl Drive

NCAR Reception and Awards6:30 PM-8:30 PM, Hyatt, Plaza Intl Ballroom J

APS Cell & Molecular Physiology Section Mixer and Awards Banquet (Advance Ticket Purchase Required)7:00 PM-10:00 PM, Itta Bena Restaurant, 9101 Intl Drive

APS Teaching of Physiology Section Banquet (Advance Ticket Purchase Required)7:00 PM-10:00 PM, BigFin Seafood Kitchen, 8046 Via Dellagio Way

APS GI & Liver Physiology Section Banquet (Advance Ticket Purchase Required)7:00 PM-11:00 PM, Tapa Toro Tapas Bar & Paella Pit, 8441 Intl Drive

APS Comparative & Evolutionary Physiology Section Dinner and Business Meeting (Advance Ticket Purchase Required)7:30 PM-10:30 PM, Copper Canyon Grill Orlando, 9101 Intl Drive

SPECIAL EVENTS:MONDAY, APRIL 8


APS Environmental & Exercise Physiology Section Social Mixer8:00 PM-10:00 PM, Hyatt, Plaza Intl Ballroom I

TUESDAY, APRIL 9

APS Frontiers in Physiology Research Community Leaders Award Breakfast (By Invitation Only)8:30 AM-10:00 AM, Hyatt, Plaza Intl Ballroom K

Joint Program Committee Meeting - Tuesday (By Invitation Only)12:00 PM-2:00 PM, Hyatt, Peacock Springs

APS History of Physiology Group Business Meeting12:30 PM-2:00 PM, Hyatt, Plaza Intl Ballroom H

WEDNESDAY, APRIL 10

The Bodil Schmidt-Nielsen 100 Year Symposium8:00 AM-5:00 PM, Hyatt, Plaza Intl Ballroom D

April 4-7, 2020San Diego, CA

SEE YOU NEXT YEAR!Thank you for attending EB.

SAN DIEGO

PROGRAM 2019 | 115

NOTES:

SAVE THE DATE: APS Annual Meeting at EB 2020April 4–7, 2020 • San Diego, California

2019 APS/ASN Conference: Control of Renal Function in Health and DiseaseJune 23–27, 2019Charlottesville, Virginiathe-aps.org/renal

2019 APS Interface of Mathematical Models and Experimental Biology: Role of the MicrovasculatureSeptember 11–14, 2019Scottsdale, Arizonathe-aps.org/mathmodels

2019 9th Annual International Conference of Aldosterone and ENaC in Health and Disease: The Kidney and BeyondOctober 2–6, 2019Estes Park, Coloradothe-aps.org/enac

Interested in making your conference idea a reality? Email [email protected].

AMERICAN PHYSIOLOGICAL SOCIETY

CONFERENCE SCHEDULE

Meetings and Conferences Ad.indd 1 3/7/2019 9:50:08 AM

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SUPPORTING:

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• Refresher Course on Physiology• High School Student and Teacher Workshop• PhUn Week Poster Session and Workshop• Numerous Section/Group New Investigator

and Trainee Awards

Find out more www.the-aps.org/ADIPartnership

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