annalsof the rheumatic diseases january 1988
TRANSCRIPT
Annals of the Rheumatic Diseases January 1988 Vol. 47 No. 1
ContentsPage
Conditioned medium from stimulated mononuclear leucocytes potentiates the ability of humanneutrophils to damage human articular cartilage EDNA J BATES, INGEBORG C KOWANKO, ANDANTONIO FERRANTE 1
Circulating inhibitor bound elastase in patients with ankylosing spondylitis and rheumatoidarthritis and the influence of sulphasalazine treatment NILS FELTELIUS AND ROGER HALLGREN 10
Effects of chrysotherapy on circulating lymphocyte numbers and subsets M D SMITH, A SMITH, M FEHR,M J AHERN, AND P J ROBERTS-THOMSON 15
Measurement of 'free' gold in patients receiving disodium aurothiomalate and the association of highfree to total gold levels with toxicity M J HEATH 18
Autoimmunity to La (SS-B) in vitro is related to HLA-DR3 in healthy subjects PATRICK J W VENABLES,SHIRLEY RIGBY, PAT A MUMFORD, JOHN MARKWICK, AND RAVINDER N MAINI 22
Pulse steroid therapy in rheumatoid arthritis: Can equivalent doses of oral prednisolone give similarclinical results to intravenous methylprednisolone? MALCOLM D SMITH, MICHAEL J AHERN, ANDPETER J ROBERTS-THOMSON 28
Synovial fluid neutrophils of patients with rheumatoid arthritis have membrane antigen changes thatreflect activation PAUL EMERY, ANGEL F LOPEZ, GORDON F BURNS, AND MATHEW A VADAS 34
Comparison of sleep in osteoarthritic patients and age and sex matched healthy controls T J LEIGH,I HINDMARCH, H A BIRD, AND V WRIGHT 40
Infusion of Iloprost, a prostacyclin analogue, for treatment of Raynaud's phenomenon in systemicsclerosIS N J MCHUGH, M CSUKA, H WATSON, G BELCHER, A AMADI, E F J RING, C M BLACK, ANDP J MADDISON 43
Kinetic investigations into the possible cause of low serum histidine in rheumatoid arthritisN G SITrON, J S DIXON, C ASTBURY, R J FRANCIS, H A BIRD, AND V WRIGHT 48
Sequential nailfold capillary microscopy in scleroderma and related disorders M L WONG, J HIGHTON,AND D G PALMER 53
Computed tomographic demonstration of calcification of the ligamenta flava of the lumbosacral spinein ankylosing spondylitis ELIESER AVRAHAMI, IRENA WIGLER, DORIT STERN, DAN CASPI, ANDMICHAEL YARON 62
Low free testosterone levels in rheumatoid arthritis T D SPECTOR, L A PERRY, G TUBB, A J SILMAN, ANDE C HUSKISSON 65
Effect of dietary restrictions on disease activity in rheumatoid arthritis DEEPA BERI, A N MALAVIYA,RENU SHANDILYA, AND R R SINGH 69
Trauma and seronegative spondyloarthropathy: rapid joint destruction in peripheral arthritistriggered by physical injury IGNAZIO OLIVIERI, SANDRA GHERARDI, CHIARA BINI, DONATELLA TRIPPI,MARIA LAURA CIOMPI, AND GIAMPIERO PASERO 73
Acute pancreatitis in systemic lupus erythematosus: report of a case unrelated to drug therapyROGER WOLMAN, CHRISTOPHER DE GARA, AND DAVID ISENBERG 77
Severe myalgia in familial Mediterranean fever: clinical and ultrastructural aspects D SCHAPIRA,R LUDATSCHER, M NAHIR, M LORBER, AND Y SCHARF 80
Correspondence 84
Book reviews 85
Notes 87
Acknowledgments 88
ASTMS CODEN: ARDIAO 47 (1) 1-88 (1988) ISSN 0003-4967
British Medical Association Tavistock Square London WC1H 9JR
Published bv British Medical Association. Tasistock Square. London WC IH 9JR. and
printed in England bh The Devonshirc Prcss Ltdi. TorquaN
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CONTENTS OF VOLUME 47
No. 1 January, 1988Conditioned medium from stimulated mononuclear leucocytes poten-
tiates the ability of human neutrophils to damage human articularcartilageEdna J. Bates, Ingeborg C. Kowanko, and Antonio Ferrante 1
Circulating inhibitor bound elastase in patients with ankylosing spondy-litis and rheumatoid arthritis and the influence of sulphasalazinetreatment
Nils Feltelius and Roger Hallgren 10Effects of chrysotherapy on circulating lymphocyte numbers and
subsetsM. D. Smith, A. Smith, M. Fehr, M. J. Ahern, and P. J. Roberts-Thomson 15
Measurement of 'free' gold in patients receiving disodium aurothio-malate and the association of high free to total gold levels withtoxicityM. J. Heath 18
Autoimmunity to La (SS-B) in vitro is related to HLA-DR3 in healthysubjects
Patrick J. W Venables, Shirley Rigby, Pat A. Mumford, JohnMarkwick, and Ravinder N. Maini 22
Pulse steroid therapy in rheumatoid arthritis: Can equivalent doses oforal prednisolone give similar clinical results to intravenousmethylprednisolone?Malcolm D. Smith, Michael J. Ahern, and Peter J. Roberts-Thomson 28
Synovial fluid neutrophils of patients with rheumatoid arthritis havemembrane antigen changes that reflect activation
Paul Emery, Angel F. Lopez, Gordon F. Burns, and Mathew A.Vadas 34
Comparison of sleep in osteoarthritic patients and age and sex matchedhealthy controls
T. J. Leigh, L. Hindmarch, H. A. Bird, and V. Wright 40Infusion of lloprost, a prostacyclin analogue, for treatment of Raynaud's
phenomenon in systemic sclerosisN. J. McHugh, M. Csuka, H. Watson, G. Belcher, A. Amadi,E. F. J. Ring, C. M. Black, and P. J. Maddison 43
Kinetic investigations into the possible cause of low serum histidine inrheumatoid arthritis
N. G. Sitton, J. S. Dixon, C. Astbury, R. J. Francis, H. A. Bird, andV. Wright 48
Sequential nailfold capillary microscopy in scleroderma and relateddisordersM. L. Wong, J. Highton, and D. G. Palmer 53
Computed tomographic demonstration of calcification of the ligamentaflava of the lumbosacral spine in ankylosing spondylitis
Elieser Avrahami, Irena Wigler, Dorit Stern, Dan Caspi, andMichael Yaron 62
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Low free testosterone levels in rheumatoid arthritisT. D. Spector, L. A. Perry, G. Tubb, A. J. Silman, and E. C. Huskisson 65
Effect of dietary restrictions on disease activity in rheumatoid arthritisDeepa Beri, A. N. Malaviya, Renu Shandilya, and R. R. Singh 69
Trauma and seronegative spondyloarthropathy: rapid joint destructionin peripheral arthritis triggered by physical injury
Ignazio Olivieri, Sandra Gherardi, Chiara Bini, Donatella Trippi,Maria Laura Ciompi, and Giampiero Pasero 73
Acute pancreatitis in systemic lupus erythematosus: report of a caseunrelated to drug therapyRoger Wolman, Christopher de Gara, and David Isenberg 77
Severe myalgia in familial Mediterranean fever: clinical and ultra-structural aspects
D. Schapira, R. Ludatscher, M. Nahir, M. Lorber, and Y. Scharf 80Correspondence 84Book reviews 85Notes 87Acknowledgments 88
No. 2 February, 1988Leading article: A possible immunochemical explanation for pregnancy
associated remissions in rheumatoid arthritis?D. R. Stanworth 89
Alterations in carbohydrate composition of serum IgG from patients withrheumatoid arthritis and from pregnant women
J. M. Pekelharing, Ellen Hepp, J. P. Kamerling, G. J. Gerwig, andB. Leiinse 91
Effects of altering dietary essential fatty acids on requirements for non-steroidal anti-inflammatory drugs in patients with rheumatoidarthritis: a double blind placebo controlled study
J. J. F. Belch, D. Ansell, R. Madhok, A. O'Dowd, and R. D. Sturrock 96Large quantities of low molecular weight IgM in mixed cryoglo-
bulinaemiaP. J. Roberts-Thomson, Alison Kennedy, and Lin Y. Koh 105
Anticardiolipin antibodies, livedo reticularis, and major cerebrovascularand renal disease in systemic lupus erythematosus
N. J. McHugh, J. Maymo, R. P. Skinner, I. James, and P. J. Maddison 110Serum amino terminal type Ill procollagen peptide and serum hyaluronan
in rheumatoid arthritis: relation to clinical and serological parametersof inflammation during 8 and 24 months' treatment with levamisole,penicillamine, or azathioprine
K. H0rslev-Petersen, K. D. Bentsen, A. Engstrom-Laurent, P. Junker,P. Halberg, and I. Lorenzen 116
Cyclosporin in rheumatoid arthritis: a double blind, placebo controlledstudy in 52 patientsMaxime Dougados, Hassane Awada, and BernardAmor 127
Salicylate ototoxicity in patients with rheumatoid arthritis: a controlledstudyJames T. Halla and Joe G. Hardin 134
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Analysis of clinical judgment helps to improve agreement in the assess-ment of rheumatoid arthritis
J. R. Kirwan, C. G. Barnes, P. G. Davies, and H. L. F. Currey 138Does active rheumatoid arthritis affect intestinal iron absorption?
H. -P. Benn, J. Drews, G. Randzio, J. M. Jensen, and H. Loffler 144The arthritis sufferer and the community: a comparison of arthritis
sufferers in rural and urban areasPaul G. L. Cornelissen, JohannesJ. Rasker, andHansA. Valkenburg 150
Behcet's disease associated with amyloidosis in Turkey and in the worldN. DilEen, M. Konige, 0. Aral, T. Erbengi, V. Uysal, N. Kogak, andE. Ozdogan 157
Pattern of Lyme arthritis in Europe: report of 14 casesJ. P. Huaux, G. Bigaignon, S. Stadtsbaeder, P. F. Zangerle, andC. Nagant de Deuxchaisnes 164
Sarcoidosis in a patient presenting with clinical and histological featuresof primary Sjogren's syndrome
R. D. Melsom, P. M. Speight, J. Ryan, and J. D. Perry 166Viewpoint: Do diets rich in polyunsaturated fatty acids affect disease
activity in rheumatoid arthritis?L. Gail Darlington 169
Correspondence 173Book reviews 175
No. 3 March, 1988Special announcements 177Review: Autoantibody profile in juvenile chronic arthritis
Alison M. Leak 178Value of joint scintigraphy in the prediction of erosiveness in early
rheumatoid arthritisT. T. Mottonen, P. Hannonen, J. Toivanen, A. Rekonen, andM. Oka 183
Relation between synovial fluid C3 degradation products and localinflammation in rheumatoid arthritis, osteoarthritis, and crystalassociated arthropathyMichael Doherty, Nora Richards, June Hornby, and RichardPowell 190
Bone resorbing activity in synovial fluids in destructive osteoarthritisand rheumatoid arthritis
W. H. Alwan, P. A. Dieppe, C. J. Elson, and J. W. B. Bradfield 198A search for retrovirus infection in systemic lupus erythematosus and
rheumatoid arthritisB. K. Pelton, Margaret North, R. G. Palmer, Winsome Hylton,Caroline Smith-Burchnell, Anne L. Sinclair, M. Malkovsky,A. G. Dalgleish, and A. M. Denman 206
Complement activation and HLA-B27Seppo Meri, Jukka Partanen, Marjatta Leirisalo-Repo, andHeikki Repo 210
Association of HLA-B35 with mucocutaneous lesions in Israeli patientswith rheumatoid arthritis receiving gold treatmentM. Tishler, D. Caspi, E. Gazit, and M. Yaron 215
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The arthropathy of cystic fibrosisJosh Dixey, Andrew N. Redington, Robin C. Butler, Michael J.Smith, John R. Batchelor, David F. Woodrow, Margaret E. Hodson,John C. Batten, and Derrick A. Brewerton 218
Failure of oral thiomalate to act as an alternative to intramuscular goldin rheumatoid arthritis
S. R. Rudge, D. Perrett, and M. Kelly 224Complications of pregnancy and benign familial joint hyperlaxity
J. G. Thornton, J. Hill, and H. A. Bird 228Morphology of surface synoviocytes in situ at normal and raised joint
pressure, studied by scanning electron microscopyJ. N. McDonald and J. R. Levick 232
Inhibition of leucotriene B4 synthesis by BW 755c does not reduce poly-morphonuclear leucocyte (PMNL) accumulation induced bymonosodium urate crystalsM. J. Forrest, V. Zammit, and P. M. Brooks 241
A. monoclonal antibody raised by immunising mice with group Astreptococci binds to agalactosyl IgG from rheumatoid arthritis
G. A. W. Rook, J. Steele, and T. Rademacher 247Pulmonary hypertension in primary Sjogren's syndrome
Madelaine T. Hedgpeth and Dennis W. Boulware 251Arthritis in Down's syndrome
J. E. Dacre and E. C. Huskisson 254Rheumatoid disease presenting as a nephrotic syndrome
C. D. Short, L. R. Solomon, N. P. Mallick and J. D. Mackay 256Conference report: Theoretical medicine: the pathogenesis of osteo-
arthritis 258Correspondence 260Book reviews 263
No. 4 April, 1988Leading article: Epstein-Barr virus infection and autoimmunity in
rheumatoid arthritisPatrick Venables 265
Reaction of antibodies to rheumatoid arthritis nuclear antigen with asynthetic peptide corresponding to part of Epstein-Barr nuclearantigen 1
Patrick J. W. Venables, Tommasz Pawlowski, Pat A. Mumford,Christina Brown, Dorothy H. Crawford, and Ravinder N. Maini 270
-T. cell cytotoxicity to Epstein-Barr virus infected B cells: comparison ofpatients with rheumatoid arthritis and their HLA identical siblings
Vivienne R. Winrow, Janice Norton, E. John Holborow, Helmut EStierle, Adam Young, and John A. Sachs 280
IgG subclass and light chain distribution of anticardiolipin and anti-DNAantibodies in systemic lupus erythematosusA. E. Gharavi, E. N. Harris, M. D. Lockshin, G. R. V. Hughes, andK. B. Elkon 286
Fuctional affinity of IgM rheumatoid factor in patients with rheumatoidarthritis and other autoimmune diseases
S. Rath, D. N. Hogben, and M. E. Devey 291
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Evidence that Chlamydia trachomatis causes seronegative arthritis inwomen
D. Taylor-Robinson, B. J. Thomas, J. Dixey, M. F. Osborn,P. M. Furr, and A. C. Keat 295
The synovial membrane in osteoarthritis: a histological study includingthe characterisation of the cellular infiltrate present in inflammatoryosteoarthritis using monoclonal antibodies
Peter A. Revell, Vivien Mayston, Peggy Lalor, and Paul Mapp 300Serum cytidine deaminase levels after withdrawal of non-steroidal anti-
inflammatory treatment in rheumatoid arthritisP. W Thompson, J. R. Kirwan, D. D. Jones, and H. L. F. Currey 308
Autoantibodies to type 11 collagen: occurrence in rheumatoid arthritis,other arthritides, autoimmune connective tissue diseases, andchronic inflammatory syndromesEdward K. K. Choi, Paul A. Gatenby, Neil W. McGill, John F.Bateman, William G. Cole, and John R. York 313
Co-trimoxazole in rheumatoid arthritis: a comparison with sulphapyridineC. Astbury, J. Hill, andH. A. Bird 323
Anti-inflammatory drugs modulate histamine release from mast cellsinduced by fibrinogen degradation products
E. Wojtecka-Lukasik, J. Stachurska, M. Kopec, and S. Maslinski 328Acute vertebral osteomyelitis complicating Streptococcus sanguis
endocarditisChristine Demers, Michel Tremblay, and Yves Lacourciere 333
Sarcoidosis presenting as antinuclear antibody positive glomerulo-nephritisMaria Cristina Soto-Aguilar and Dennis W. Boulware 337
Polymyositis after propylthiouracil treatment for hyperthyroidismWilliam J. Shergy and David S. Caldwell 340
Discovertebral destruction in ankylosing spondylitis complicated byspinal cord compression
P. Jobanputra, B. Kirkham, 0. Duke, A. Crockard, and G. D. Panayi 344Viewpoint: Synovial lining cell hyperplasia in rheumatoid arthritis:
dogma and factB. Henderson, P. A. Revell and J. C. W. Edwards 348
Correspondence 350Book reviews 351Special announcements 352
No. 5 May, 1988Identification by cell electrophoresis of a subpopulation of poly-
morphonuclear cells which is increased in patients with rheumatoidarthritis and certain other rheumatological disorders
K. A. Brown, J. D. Perry, C. Black, and D. C. Dumonde 353Reduction of the surface charge of blood polymorphonuclear cells by
rheumatoid sera and heat induced aggregated human IgG (HAGG)K. A. Brown, D. McCarthy, J. D. Perry, and C. Dumonde 359
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Coagulation screen is more specific than the anticardiolipin antibodyELISA in defining a thrombotic subset of lupus patientsRonald H. W. M. Derksen, Paula Hasselaar, Laya Blokzijl, FritsH. J. Gmelig Meyling, and Philip G. De Groot 364
Demonstration of impaired T cell regulation of Epstein-Barr virusstimulated B lymphocytes in rheumatoid arthritis with HLAidentical, disease discordant sibling pairsMarie-Claude Fawcett, D. J. Walker, and 1. D. Griffiths 372
Binding of haptoglobin, inter-a-trypsin inhibitor, and a, proteinaseinhibitor to synovial fluid hyaluronate and the influence of theseproteins on its degradation by oxygen derived free radicalsNongporn Hutadilok, Peter Ghosh, and Peter M. Brooks 377
Psoriatic spondyloarthropathy: a long term prospective studyJohn G. Hanly, M. Lynn Russell, and Dafna D. Gladman 386
Adenosine deaminase activity in rheumatoid pleural effusion1. Ocana, E. Ribera, J. M. Martinez-Vazquez, 1. Ruiz, E. Bejarano,C. Pigrau, and A. Pahissa 394
Immunohistology of rheumatoid nodules and rheumatoid synoviumN. A. Athanasou, J. Quinn, C. G. Woods, and O'd McGee 398
Decreased iron absorbance in patients with active rheumatoid arthritis,with and without iron deficiency
J. Weber, J. M. Werre, H. W. Julius, and J. J. M. Marx 404Antiocardiolipin antibodies in patients with primary immunodeficiency
diseasesDora Pascual-Salcedo, Maria Cruz Garcia Rodriguez, MargaritaLopez Trascasa, and Gumersindo Fontan 410
Differential response to compressive loads of zones of canine hyalinearticular cartilage, micromechanical, light and electron microscopicstudies
Patricia O'Connor, Constance R. Orford, and Dugald L. Gardner 414Contact allergy to gold after systemic administration of gold for rheuma-
toid arthritis1. P. Wicks, D. Wong, R. B. McCullagh, and A. Fleming 421
Subacute bacterial endocarditis in a patient with ankylosing spondylitisRichardA. Hoppmann, Christopher M. Wise, Venkata R. Challa, andJames E. Peacock 423
Acute confusional state and hyponatraemia due to inappropriate anti-diuretic hormone secretion in polyarteritis nodosa
J. S. H. Gaston, D. G. /. Scott, and P. A. Bacon 428Viewpoint: B27 positive diseases versus B27 negative diseases
A. Linssen, and T. E. W.Feltkamp 431Correspondence 440Notes 440
No. 6 June, 1988Increased incidence of spontaneous abortion and infertility in women
with scleroderma before disease onset: a controlled studyAlan J. Silman and Carol Black 441
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Increased sensitivity of lymphocytes from patients with systemicautoimmune diseases to DNA alkylation by the methylatingcarcinogen N-methyl-N-nitrosourea
P. D. Lawley, R. Topper, A. M. Denman, W. Hylton, L. D. Hill, andG. Harris 445
Polymorphonuclear leucocyte function and previous yersinia arthritis:correlation of enhanced superoxide production with late mani-
festationsHeikki Repo, Paivi Koivuranta-Varra, and Marjatta Leirisalo-Repo 452
Evaluation of disease activity in rheumatic patients by leucocyteadhesiveness/aggregationShlomo Berliner, Moshe Fried, Dan Caspi, Abraham Weinberger,Michael Yaron, Jack Pinkhas, and Moshe Aronson 458
P component in the synovium in rheumatoid and osteoarthritisM. G. Butler, A. J. D'Ardenne, and D. L. Scott 463
Urinary proteoglycan degradation product excretion in patients withrheumatoid arthritis and osteoarthritis
J. Krajickova and J. Macek 468Changes of lymphocyte membrane fluidity in rheumatoid arthritis: a
fluorescence polarisation studyE. Beccerica, G. Piergiacomi, G. Curatola, and G. Ferretti 472
Peptic ulcer in rheumatoid arthritisD. Farah, R. D. Sturrock, and R. L. Russell 478
Alterations in appendicular skeletal mass in patients with rheumatoid,psoriatic, and osteoarthropathy
C. Cooper, V. Poll, M. McLaren, S. O'n Daunt, and M. . D. Cawley 481Inflammatory joint disease: a comparison of liposome scanning, bone
scanning, and radiographyM. M. O'Sullivan, N. Powell, A. P. French, K. E. Williams,J. R. Morgan, and B. D. Williams 485
Serum and synovial fluid adenosine deaminase activity in patients withrheumatoid arthritis, osteoarthritis, and reactive arthritis
H. Yuksel and T. F. Akoglu 492A double blind, placebo controlled trial of intravenous methylpred-
nisolone in systemic lupus erythematosusC. G. Mackworth-Young, J. David, S. H. Morgan, and G. R. V. Hughes 496
Pancytopenia related to azathioprine in rheumatoid arthritisM. E. C. Jeurissen, A. M. Th Boerbooms, and L. B. A. Van de Putte 503
Sodium aurothiomalate does not block interleukin 1 production inrabbitsYehuda Zurovsky, Helen P. Laburn, Duncan Mitchell, and AngelaRuck 506
Effect of two gold compounds on lysosomesPernille M0ller Graabaek and Susanne M0ller Pedersen 509
Effect of auranofin on plasma fibronectin, C reactive protein, and albuminlevels in arthritic ratsKevin M. Connolly, Vera J. Stecher, and Donald J. Pruden 515
Intervertebral infection due to Candida albicans in an intravenous heroinabuser
L. F. Rowe, E. D. Wright, C. S. Higgens, and J. P. Burnie 522Correspondence 526Book reviews 527Note 528
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No. 7 July, 1988Leading article: Immunisation of patients with rheumatoid arthritis and
systemic lupus erythematosusLynne Turner-Stokes and David A. Isenberg 529
In vitro response to influenza immunisation by peripheral bloodmononuclear cells from patients with systemic lupus erythematosusand other autoimmune diseases
L. Turner-Stokes, G. Cambridge, T. Corcoran, J. S. Oxford, andM. L. Snaith 532
An IgG subclass imbalance in connective tissue diseaseR. A. Kay, K. J. Wood, R. M. Bernstein, P. J. L. Holt, andR. S. H. Pumphrey 536
Autonomic neuropathy in systemic sclerosisP. S. Klimiuk, Lesley Taylor, R. D. Baker, and M. I. V. Jayson 542
Class-specific rheumatoid factors, DR antigens, and amyloidosis inpatients with rheumatoid arthritis
C. P. J. Maury, A.-M. Teppo, F. Wafin, 0. Wegelius, C. Friman, andS. Koskimies 546
Use of single photon emission computed tomography (SPECT) to studythe distribution of 90Y in patients with Baker's cysts and persistentsynovitis of the knee
T. Smith, D. J. Shawe, J. C. W. Crawley, and J. M. Gumpel 553Comparison of serial synovial fluid cytology in rheumatoid arthritis:
delineation of subgroups with prognostic implicationsM. J. Davis, J. Denton, A. J. Freemont, and P. J. L. Holt 559
Australian mortality statistics for rheumatoid arthritis 1950-81: analysisof death certificate data
I. P. Wicks, J. Moore, and A. Fleming 563Phytohaemagglutinin induced proliferation of lymphocytes from
patients with rheumatoid arthritis and iron deficiencyRex J. Polson, Adrian Bomford, Hedley Berry, and Roger Williams 570
Raised serum albumin in hip osteoarthrosis: a comparative study inwomen of some blood chemical parameters in aging and in casesof femoral neck fractures, osteoporotic vertebral crush fractures,and hip osteoarthrosis
Charles-Henri Rapin, and Rene Lagier 576A. double blind multicentre study of OM-8980 and auranofin in
rheumatoid arthritisT. L. Vischer 582
Expression of CD 21, CD 22, and the mouse erythrocyte receptor onperipheral B. lymphocytes in rheumatoid arthritisSabine Hildebrandt, Iris Von Der Heydt, and Peter Von Wichert 588
Seronegative spondarthritis associated with Takayasu's arteritisM. Magar0, L. Altomonte, L. Mirone, A. Zoli, and G. Corvino 595
Bacterial endocarditis presenting as acute monarthritisA. Doube and A. Calin 598
Sensorineural hearing loss in adult onset Still's diseaseHarry M. Markusse, Berend Stolk, Andel G. L. Van Der Mey,Johanna M. De Jonge-Bok, and Karel J. Heering 600
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Response of rheumatoid arthritis to chemotherapy for Hodgkin'sdisease in a patient with IgA deficiency and overlap connectivetissue disease
Michael G. Cohen, Beatrice Janssen, and John Webb 603Extensive cerebral infarction due to involvement of both anterior
cerebral arteries by Wegener's granulomatosisJ. Satoh, N. Miyasaka, T. Yamada, T. Nishido, M. Okuda,T. Kuroiwa, and R. Shimokawa 606
Conference report: Third International Antiphospholipid Conference:barbecues, rum punches, and kaps
E. Nigel Harris and Graham R. V. Hughes 612Correspondence 615Book review 616Notes 616
No. 8 August, 1988Editorial: Is the gut intrinsically abnormal in rheumatoid arthritis? 617Effects of prostaglandin E2 on disease activity, gastric secretion and
intestinal permeability, and morphology in patients with rheu-matoid arthritis
A. E. K. Henriksson, C. Tagesson, A. Uribe, K. Uvnas-Moberg,C.-E. Nord, R. Gullberg, and C. Johansson 620
Participation of antigens related to the psoriasis associated antigen, psop27, in immune complex formation in patients with ankylosingspondylitisEyvind R0dahl, Kjetil Abakk, and Ole-Jan Iversen 628
Development of connective tissue disease in patients presenting withRaynaud's phenomenon: a six year follow up with emphasis on thepredictive value of antinuclear antibodies as detected by immuno-blottingCees G. M. Kallenberg, Aaktje A. Wouda, Margot H. Hoet, andWalther J. Van Venrooij 634
Induction of antinuclear antibodies in patients with rheumatoid arthritisreceiving treatment with human recombinant interferon gammaM. Seitz, M. Franke, and H. Kirchner 642
Relation of microscopic haematuria in ankylosing spondylitis to circu-lating IgA containing immune complexesAndr6 J. Peeters, A. Warmold L. Van Den Wall Bake, Annette D.Van Dalsen, and Marie-Louise Westedt 645
Prediction of erosiveness and rate of development of new erosions inearly rheumatoid arthritis
T. T. Mottonen 648Methotrexate in rheumatoid arthritis: a prospective study in Israeli
patients with immunogenetic correlationsMoshe Tishler, Dan Caspi, Tal 0. Rosenbach, Beno Fishel,Irena Wigler, Rafael Segal, Ephraim Gazit, and Michael Yaron 654
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Spinal trabecular bone mineral content in patients with non-steroidtreated rheumatoid arthritis
J. E. Compston, E. 0. Crawley, C. Evans, and M. M. O'Sullivan 660Serum a, antichymotrypsin concentration as a marker of disease activity
in rheumatoid arthritisM. D. Chard, J. Calvin, C. P. Price, T. E. Cawston, and B. L. Hazleman 665
Normal cardiovascular autonomic function in patients with systemicsclerosis (CREST variant)Maria E. Suarez-Almazor, Eduardo Bruera, andAnthony S. Russell 672
Complement mediated inhibition of immune precipitation in rheumatiodarthritis: studies on interaction of heat aggregated IgG with IgMrheumatoid factorM. M. O'Sullivan, N. Amos, and B. D. Williams 675
Chorea in systemic lupus erythematosus: association with antiphospho-lipid antibodiesM. A. Khamashta, A. Gil, B. Anciones, P. Lavilla, M. E. Valencia,V. Pintado, and J. J. Vazquez 681
Cathepsin B. as a marker of the dedifferentiated chondrocyte phenotypeAntonio Baici, Angela Lang, Dorothy Horler, and Margrit Knopfel 684
Osteomalacia and coeliac disease presenting as isolated dactylitisA. S. M. Jawad, S. B. Squire, and J. D. Perry 692
Osteomyelitis presenting as a swollen elbow in a patient with theacquired immune deficiency syndrome
B. T. Goh, A. S. M. Jawad, D. Chapman, S. J. Winceslaus,G. E. Forster, and J. D. Perry 695
Viewpoint: Rheumatoid arthritis and gut related lymphocytes: theiteropathy concept
P. Sheldon 697Correspondence 701Note 704
No. 9 September, 1988Leading article: Idiotypes and anti-idiotypes: What are they trying to
tell us?Relation of antivimentin antibodies to anticardiolipin antibodies in
systemic lupus erythematosusMartin A. Blaschek, Michael Boehme, Jean Jouquan, Anne-MarieSimitzis, Spyros Fifas, Paul Le Goff, and Pierre Youinou 708
Disease activity in systemic lupus erythematosus related to a range ofantibodies binding DNA. and synthetic polynucleotidesDavid A. Isenberg, Carol Dudeney, Warren Williams, AndrewTodd-Pokropek, and B. David Stollar 717
Lymphocytotoxic antibodies in systemic lupus erythematosus: studiesof their temperature dependence, binding characteristics, andspecificity in vitro
P. W Peake, J. D. Greenstein, V. Timmermans, L. Gavrilovic, andJ. A. Charlesworth 725
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Polymyalgia rheumatica and temporal arteritis: a retrospective analysisof prognostic features and different corticosteroid regimens(11 year survey of 210 patients)
D. Delecoeuillerie, P. Joly, A. Cohen De Lara, and J. B. Paolaggi 733The first international standard for antibodies to double stranded DNA
T. E. W. Feltkamp, T. B. L. Kirkwood, R. N. Maini, and L. A. Aarden 740Ultrastructural localisation of alkaline phosphatase activity in osteo-
arthritic human articular cartilageJ. A. Rees and S. Y. Ali 747
Lack of objective evidence of stiffness in rheumatoid arthritisP. S. Helliwell, A. Howe, and V. Wright 754
Screening for proteinuria in a rheumatology clinic: comparison ofdipstick testing, 24 hour urine quantitative protein, and protein/creatinine ratio in random urine samples
Stuart H. Ralston, Nell Caine, lain Richards, Denis O'Reilly,Roger D. Sturrock, and Hilary A. Capell 759
Adult onset Still's disease and viral infectionsJacques M. G. W. Wouters, Johan Van Der Veen, Levinus B. A.Van de Putte, and Dirk-Jan R. A. M. de Rooij 764
Tumour necrosis factor in synovial exudatesFrancesco S. Di Giovine, George Nuki, and Gordon W. Duff 768
Clinical assessment of disease activity in rheumatoid arthritis:evaluation of a functional test
A. A. Kalla, T. J. v W. Kotze, 0. L. Meyers, and N. D. Parkyn 773Ankylosing spondylitis with predominant involvement of the cervical
spine in a woman with Behqet's syndromeIgnazio Olivieri, Gabriele Gemignani, Francesco Busoni, FaustoPecori, Emilio Camerini, Donatella Trippi, and Giampiero Pasero 780
Life threatening acute pneumonitis during low dose methotrexatetreatment for rheumatoid arthritis: a case report and review of theliteratureM. G. Ridley, C. S. Wolfe, and J. A. Mathews 784
Correspondence 789Book reviews 792Note 792
No. 10 October, 1988Influence of diet with different lipid composition on neutrophil chemi-
luminescence and disease activity in patients with rheumatoidarthritisM. Magaro', L. Altomonte, A. Zoli, L. Mirone, P. De Sole,G. Di Mario, S. Lippa, and A. Oradei 793
Chondronectin in human synovial fluidSteven Carsons and Valerie J. Horn 797
Activation of neutral metalloprotease in human osteoarthritic kneecartilage: evidence for degradation in the core protein of sulphatedproteoglycanJohanne Martel-Pelletier, Jean-Pierre Pelletier, and Charles J.Malemud 801
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Palmoplantar pustulosis and sternocostoclavicular arthro-osteitisEva Edlund, Ulf Johnsson, Lars Lidgren, Holger Pettersson,Gunnar Sturfelt, Bjorn Svensson, Jan Theander, and HelenaWillen 809
Predictive clinical and laboratory parameters for serum zinc and copperin rheumatoid arthritisHelena Mussalo-Rauhamaa, Yrjo T. Konttinen, Jari Lehto, andVisa Honkanen 816
Specificity of anti-Sm antibodies by ELISA for systemic lupus ery-thematosus: increased sensitivity of detection using purifiedpeptide antigensM. Field, D. G. Williams, P. Charles, and R. N. Maini 820
Increased concentrations of proteoglycan components in the synovialfluids of patients with acute but not chronic joint disease
A. Ratcliffe, M. Doherty, R. N. Maini, and T. E. Hardingham 826Circulating levels of sialic acid and glycosaminoglycans: a diagnostic
test for ankylosing spondylitisA. K. Susheela, Taposh K. Das, Jasvir S. Khurana, A. Jayaswal,and P. K. Dave 833
Perivascular infiltration in normal skin of patients with rheumatoidarthritis: association with rheumatoid factors and HLA-DR antigens
H. J. Bernelot Moens, H. J. W. Ament, Th M Vroom, T. E. W.Feltkamp, and J. K. Van der Korst 838
Chromosome 14 markers in rheumatoid arthritisW. Ollier, W. Thomson, S. Welch, G. G. de Lange, and A. Silman 843
Immune mediated mechanism for thrombosis: antiphospholipid anti-body binding to platelet membranesMunther A. Khamashta, E. Nigel Harris, Azzudin E. Gharavi,Genevieve Derue, Antonio Gil, Juan Jose Vazquez, and GrahamR. V. Hughes 849
Effects of murine recombinant interleukin 1 on intact homologousarticular cartilage: a quantitative and autoradiographic studyWim B. Van Den Berg, Fons A. J. Van de Loo, Wil A. Zwarts, andIvan G. Otterness 855
Triple crystal disease: monosodium urate monohydrate, calcium pyro-phosphate dihydrate, and basic calcium phosphate in a single jointPaul B. Halverson and Lawrence M. Ryan 864
Infection of a prosthetic knee joint with Peptostreptococcus magnusUrsula M. Davies, Alison M. Leak, and Jayshree Dave 866
Pulmonary haemorrhage, pulmonary infarction, and the lupus anti-coagulant
H. S. Howe, M. L. Boey, K. Y. Fong, and P. H. Feng 869Large granular lymphocytosis associated with rheumatoid arthritis
A. Samanta, I. Grant, F. E. Nichol, J. H. Pringle, J. K. Wood, andA. C. Campbell 873
Conference report: Advances in the assessment of arthritisH. A. Bird 876
Correspondence 878Note 880
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No. 11 November, 1988Review: Neovascularisation and its role in the osteoarthritic process
Robert A. Brown and Jacqueline B. Weiss 881Humoral immunity to link protein in patients with inflammatory joint
disease, osteoarthritis, and in non-arthritic controlsA. K. Austin, R. N. Hobbs, J. C. Anderson, R. C. Butler, andB. A. Ashton 886
Immunoglobulin allotype Gm(1 ,2;21) in ankylosing spondylitis withperipheral arthritis
R. Mierau, C. A. von Muhlen, H. Zarnowski, E. Genth, andP. W Hartl 893
Reaction of rheumatoid factors with IgG3 monoclonal anti-Rh(D) anti-bodies: more frequent reactivity to a monoclonal antibody of theGm allotype G3m(5) in rheumatoid patients negative for G3m(5)Alison H. Puttick, Elizabeth A. Williamson, A. H. Merry, Belinda M.Kumpel, K. M. Thompson, and Valerie E. Jones 898
Standardisation of the quantitative determination of antinuclear anti-bodies (ANAs) with a homogeneous pattern
T. E. W. Feltkamp, F. Klein, and M. B. J. A. Janssens 906Physiology of the retrocalcaneal bursa
Juan J. Canoso, Nancy Liu, Mark R. Traill, and Val M. Runge 910Correlation of the activation of the fourth component of complement
(C4) with disease activity in systemic lupus erythematosusG. Senaldi, V. A. Makinde, D. Vergani, and D. A. Isenberg 913
Clinical and autoantibody correlations in Orientals with systemic lupuserythematosusM. L. Boey, C. L. Peebles, G. Tsay, P. H. Feng, and E. M. Tan 918
Combined suppressive drug treatment in severe refractory rheumatoiddisease: an analysis of the relative effects of parenteral methyl-prednisolone, cyclophosphamide, and sodium aurothiomalateM. T. Walters, and M. I. D. Cawley 924
Survey of the long term incidence of osteonecrosis of the hip andadverse medical events in rheumatoid arthritis after high doseintravenous methylprednisolone
I. A. Williams, A. D. Mitchell, W. Rothman, P. Tallett, K. Williams,and P. Pitt 930
An evaluation of the dynamic qualities of isometric grip strengthP. S. Helliwell, A. Howe, and V. Wright 934
Experimental arthritis in C57blackI6 normal and beige (Chediak-Higashi)mice: in vivo and in vitro observations on cartilage degradationJoost Schalkwijk, Leo A. B. Joosten, Wim B. van den Berg, andLevinus B. A. van de Putte 940
Diagnostic and therapeutic problems in two patients with antiphospho-lipid antibodies, heart valve lesions, and transient ischaemic attacks
R. A. Asherson, D. G. Gibson, D. W. Evans, E. Baguley, and G. R. V.Hughes 947
Cerebellar ataxia in systemic lupus erythematosus: three case reportsR. R. Singh, K. Prasad, AshokKumar, Anoop Misra, K. Padmakumar,and A. N. Malaviya 954
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lschaemic necrosis of the ilium complicating haemolytic anaemia dueto an unstable haemoglobin
N. W. McGill, P. Warburton, H. Kronenberg, J. E. Hassall, andM. A. Rossleigh 957
Constrictive pericarditis complicating dermatomyositisRami Tamir, A. J. Pick, and Emanuel Theodor 961
Correspondence 964Book reviews 967Notes 968
No. 12 December, 1988Review: Psychological factors in patients with chronic rheumatoid
arthritisBahv Oberai and John R. Kirwan 969
Mechanism of anaemia in rheumatoid arthritis: demonstration of raisedinterleukin 1D concentrations in anaemic patients and of inter-leukin 1 mediated suppression of normal erythropoiesis andproliferation of human erythroleukaemia (HEL) cells in vitro
C. P. J. Maury, L. C. Andersson, A-M. Teppo, S. Partanen, andE. Juvonen 972
Adverse reproductive outcomes in women who subsequently developrheumatoid arthritisAlan J. Silman, Eve Roman, Valerie Beral, and Ann Brown 979
Outcome of pregnancy in patients with autoimmune rheumatic diseasebefore the disease onsetA. Siamopoulou-Mavridou, M. N. Manoussakis, A. K. Mavridis,and H. M. Moutsopoulos 982
Lymphoproliferative cancer and other malignancy in patients withrheumatoid arthritis treated with azathioprine: a 20 year follow upstudyAlan J. Silman, John Petrie, Brian Hazleman, and Stephen J. W.Evans 988
Haematuria in rheumatoid arthritis: a follow up studyC. A. Kelly, P. Mooney, L. D. Hordon, and I. D. Griffiths 993
Scintimetric assessment of synovitis activity during treatment withdisease modifying antirheumatic drugs
Niels Olsen, Poul Halberg, Ole Halskov, and Michael W. Bentzon 995Ankylosing spondylitis without B27: no evidence for gene conversion
C. T. Pease, S. A. Ellis, A. J. McMichael, and D. A. Brewerton 1001Immunoglobin A. in the skin of patients with ankylosing spondylitis
Antonio Collado, Raimon Sanmarti, Isabel Bielsa, Teresa Castel,Eduardo Kanterewicz, Juan D. Canete, Maria A. Branc6s, andJaime Rotes-Querol 1004
Antibodies to type 11 and XI collagens: evidence for the formation ofantigen specific as well as cross reacting antibodies in patients withrheumatoid arthritis
Keith Morgan, Catherine Buckee, Ian Collins, Shirley Ayad,Roy B. Clague, and P. J. Lennox Holt 1008
Effect of intermittent stretch on immobilised musclePamela E. Williams 1014
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Atrioventricular conduction disturbance as an early feature of- Reiter'ssyndrome
J. F. Haverman, G. A. Van Albada-Kuipers, H. J. M. Dohmen, andB. A. C. Dijkmans 1017
Relapsing polychondritis mimicking rheumatoid arthritisP. Schlapbach, N. J. Gerber, P. Ramser, and F. M. Van't Hooft 1021
Intra-articular apatite deposition in mixed connective tissue disease:crystallographic and technetium scanning characteristics
C. W. Hutton, P. J. Maddison, A. J. Collins, and J. A. Berriman 1027Steroid resistant pleural effusion in systemic lupus erythematosus
treated with tetracycline pleurodesisM. H. Gilleece, C. C. Evans, and R. C. Bucknall 1031
Notes 1033Index 1035
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