ANIDRA AND ITS MANAGEMENT – A REVIEW

INSTITUTE FOR POSTGRADUATE TEACHING AND RESEARCH IN AYURVEDAGUJARAT AYURVED UNIVERSITY

JAMNAGAR – 361 008

Scholar

Keval Goti

Guide

Kalpana Patel

Co-Guide

B.R.Patel

PURPOSE

Ahara (diet), Nidra (sleep) and Brahmacharya (celibacy), are mentioned as three

Upastambhas (sub-supporting pillars) which play an important role in

maintaining the health. The inclusion of Nidra in three Upastambha signifies its

importance

It is stated that ;

happiness & sorrow,

growth & wasting,

strength & weakness,

virility & impotence and

knowledge & ignorance

as well as the existence of life and its cessation depend on the sleep.

• A disease condition, where lack or less sleep (Nidra) seen is

known as Anidra which termed as Insomnia in Medical science.

• The modern medical science is still not having a definite treatment

for insomnia.

• Although hypnotics, sedative, anxiolytic, psychotropic are evolved

they have got their own limitations because of their hazardous

adverse effects.

• Therefore, such agents cannot be safe for a long period. Hence, it

becomes imperative to search out the drugs which are safe and

effective from natural systems of medicine like Ayurveda which

can help patients of insomnia.

MATERIAL AND METHOD

In IPGT &RA, Jamnagar total 11 dissertation work has been

carried out on Anidra management till date, from which studies

carried out in the period 2001 to 2015 were analyzed and

presented in scientific manner.

1. Comparative study on the effect of

Sneha Dhara and Jala Dhara in Anidra

(joshi chinmay- 2013)

1. Jatamansi Taila Dhara (Group A)

Drug: Jatamansi Taila.

Dose: 1 lit.

Duration: 45 minutes for 2 weeks

2. Jala Shirodhara (Group B)

Drug: Jala.( Luke warm water)

Dose: 1 lit.

Duration: 45 minutes for 2 weeks.

Jaladhara was performed about 45 minutes daily in the morning

for 2weeks

Group-A

Jatamansi Taildhara

Group-B

Jaladhara

Total No. of patient 31 13 out of (15) 14 out of (16)

Complete Remission :

100% relief

0% 0%

Marked Improvement :

>75% relief

7.69% 0%

Moderate Improvement :

>50 % to 75 % relief

76.92% 85.71%

Mild Improvement : 25 %

to 50 % relief

15.38% 14.29%

Unchanged : <25 % or No

relief

0% 0%

Result of clinical study

2. Anil kumar singh (2007) – A clinical study of Manasika

Bhavas in Anidra W.S.R to stress induced chronic insomnia

and its management with Mamsyadi Ghrita & Dashmoola

kwatha shirodhara–(kayachikitsa,m.D.Thesis)

1. Group-A.Mamsyadi Ghrita (MG)

Drug : Jatamamsi, Shankhapushpi, Ashwagandha, Tagar formulated as Ghrita.

Dose : 20 g twice a day orally

Anupana : Lukewarm water

Duration : 6 weeks

Follow up : one month

2. Group-B. Dashamula Kwatha –Shirodhara (SG)

• Drug : Dashamula Kwatha ,

Dose : 500 gm/day (2 liter kwatha form)

Duration : 21 Days

Follow up : one month.

Group-A

Mamsyadi Ghrita Group

Group-B

Dashamula Kwatha

Dhara Group

Total No. of patient 30 15 8

Complete Remission :

100% relief

0% 0%

Marked Improvement :

76-99% relief

15% 25%

Moderate Improvement :

51 % to 75 % relief

46.67% 50%

Mild Improvement : 25 %

to 50 % relief

33.33% 25%

Unchanged : <25 % or No

relief

0% 0%

Result of clinical study

3. Vansh bina (2008) – A clinical study on Manasika

Bhavas in Anidra W.S.R to stress induced insomnia

and its management with Tagaradi kwatha and

Mahishi Dugdha Shirodhara

(kayachikitsa,m.D.Thesis)

1.Group-A. Tagaradi Kwatha (TK)

Drug: Jatamamsi, Shankhapushpi, Ashwagandha, Tagar, Brahmi,

Draksha, Katuki, Parpatak, Dashamula, Musta,

Raktachandana, Amaltas formulated as Kwatha.

Dose: 40gm/day (Into two divided doses each of 20 gms)

Duration: 6 weeks

2. Group-B. Mahishi Dugdha Shirodhara (SG)

Drug: Mahishi Dugdha.

Dose: 1 liter Milk

Duration: 21 Days

Dugdhadhara was performed about 30 minutes daily in the morning

between 8:00 to 10:30 AM for 21 days with lukewarm Milk.

Group-A

Tagaradi Kwatha

Group-B.

Mahishi Dugdha Shirodhara

Total No. of patient 31 17 10

Complete Remission :

100% relief

0% 0%

Marked Improvement :

>75% relief

0% 20%

Moderate Improvement :

>50 % to 75 % relief

23.53% 60%

Mild Improvement : 25 %

to 50 % relief

76.47% 20%

Unchanged : <25 % or No

relief

0% 0%

Result More effactive

Result of clinical study

4. M.P.S.K.R. Muthugala (2013) - Evaluation of

Parasikayavanyadi capsule in the management of

Anidra W.S.R. to insomnia (kayachikitsa, M.D.

Thesis)

Parsikayavanyadi capsule

Parasikayavani-1/4 th part

Jatamansi -1 part

Shankhapushpi-7 Bhavanas of Svarasa

Kushmanda -7 Bhavanas of Svarasa

Grouping

Group P.V

(Parsikyavanadi Vati)

Group P.M

(along with allopathy

medicine)

Group P.C

(Placebo)

Dose 5 Capsules 5 Capsules 5 Capsules

Time At bed time At bed time At bed time

Anupana Luke warm water Luke warm water Luke warm water

Duration One month One month One month

Parasikayavanyadi

capsule group P.V

Parasikayavanyadi

capsule group P.M:

Placebo

capsule

group P.C:

Total No. of patient 20 20 12

Complete Remission :

100% relief

0% 0% 0%

Marked Improvement :

>75% relief

0% 0% 8.33%

Moderate Improvement

: >50 % to 75 % relief

40% 55% 0%

Mild Improvement : 25

% to 50 % relief

50% 40% 0%

Unchanged : <25 % or

No relief

10% 5% 75%

Result of clinical study

5. Nirmal Dhamini (2004) ‘Role of Manasika

Bhavas in Anidra and its management with

certain indigenous drugs and Shirodhara’.

1. Group A (Apamargadi Vati Group) :

Dose : 1 gm t.d.s.

Duration : 8 weeks

Anupana : With milk (buffalo)

2. Group B (Taila Dhara Group) :

Drug : Kshira Bala Taila

Duration : Shirodhara done for 30 min. daily in the morning for 2 weeks.

3.Group C (Combined Group)

In this group combined therapy has been given as mentioned in the groups above.

Group A

(Apamargadi Vati

Group) :

• Group B

(Taila Dhara

Group) :

Group C

(Combined

Group)

Total No. of patient 20 20 12

Complete Remission :

100% relief

0% 0% 0%

Marked Improvement :

>75% relief

0% 62.50% 62.50%

Moderate Improvement :

>50 % to 75 % relief

85.70% 25% 37.50%

Mild Improvement : 25 % to

50 % relief

14.30% 12.50% 0%

Unchanged : <25 % or No

relief

0% 0% 0%

6. A clinico comparative study of Madhukadi taila

Shiropichu and Pippalimoola Churna in the

management of Anidra w.S.R. To insomnia

Group A:

• Drug : Madhukadi Taila

• Form : Taila - Pichu

• Dose : 50 ml approximately

• Mode of administration : Local application(60minutes)

• Time : At morning

• Duration : 2 weeks

Group B:

• Drug : Pipplimoola

• Form : Churna

• Dose : 1 gm twice a day

• Mode of administration : Oral

• Time of administration : After food

• Anupana : Guda (Jaggery) 2 gm twice a day

• Duration : 4 weeks

Group A Madhukadi

Taila Shiropichu

• Group B

Pipplimoola Churna

Total No. of patient 30 30

Complete Remission :

100% relief

0% 0%

Marked Improvement :

75% to 99%relief

20% 23.33%

Moderate Improvement

: 50 % to 75 % relief

53.33% 40%

Mild Improvement : 25

% to 50 % relief

20% 33.3%

Unchanged : 25 % or

No relief

6.67% 3.33%

result Highly significant insignificant

7. Kalpesh panara (2013-2014) – A pharmaco

clinical evaluation of Beejapoorapatra (leave of

citrus medica linn.) W.S.R to insomnia.-

(Dravyaguna, ph.D thisis)

Group A:

• Drug :Powder of Beejapura

• Dose: 3g

• Anupana :Honey (5g)

• Route of administration :Oral

• Time of administration :Half an hour before bed time

• Duration of treatment :4 weeks

• Follow-up :2 weeks

Group B:

• Drug: leaves Powder of Jatamansi

• Dose: 3g

• Anupana :Honey (5g)

• Route of administration: Oral

• Time of administration: Half an hour before bed time

• Duration of treatment: 4 weeks

• Follow-up :2 weeks

Group A

Powder of Beejapura

• Group B

Leaves Powder of

Jatamansi

Total No. of patient 33 33

Complete Remission :

100% relief

7% 13%

Marked Improvement :

76% to 99%relief

3% 9%

Moderate Improvement

: 51 % to 75 % relief

7% 19%

Mild Improvement : 26

% to 50 % relief

40% 59%

Unchanged : up to 25

% relief

43% 3.33%

result Highly significant

8. Krutika joshi (2013-2014) – a pharmaco clinical

evaluation of Pippalimoola (root of piper longum)

W.S.R to insomnia.- (Dravyaguna, ph.D thesis)

Group A:

• Drug: Powder of Pipplimula

• Dose : 2g

• Anupana:Jaggery(5g)

• Route of administration :Oral

• Time : Half hour before bed time once at night

• Duration : 4 weeks

• Follow up: 2 weeks

Group B:

• Drug: Powder of Jatamansi rhizome

• Dose : 2g

• Anupana:Jaggery(5g)

• Route of administration :Oral

• Time : Half hour before bed time once at night

• Duration : 4 weeks

• Follow up: 2 weeks

Group A

Powder of Pippalimula

• Group B

leaves Powder of

Jatamansi

Total No. of patient 28 28

Complete Remission :

100% relief

0% 0%

Marked Improvement :

76% to 99%relief

42.86% 3.57%

Moderate Improvement

: 501% to 75 % relief

57.14% 89.29%

Mild Improvement : 26

% to 50 % relief

0% 7.14%

Unchanged : up to25 %

relief

0% 0%

result Similar effect to

standard drug

CONCLUSION

Therapies and formulation of the study which has givensignificant result were enlisted below.

Madhukadi Taila Dhara,

Mahishi Dugdhdhara,

Jatamansi powder,

Parsikyavanyadi capsule,

Mansyadi Ghrita,

Apamargadi Vati,

Jatamansi Tailadhara,

Dashmoola kwatha dhara

Madhukadi Taila Shiropichu

From the review work it can be concluded that internalmedication with Shirodhara is much effective in themanagement of Anidra.