angiostatin : a novel angiogenesis inhibitor that mediates the suppression of metastases
DESCRIPTION
Angiostatin : A Novel Angiogenesis Inhibitor That Mediates the Suppression of Metastases by a Lewis Lung Carcinoma Michael S. O ’Reilly , Lars Holmgren , Yuen Shing , Catherine Chen , Rosallnd A. Rosenthal , Marsha Moses, William S. Lane , Yihai Cao, - PowerPoint PPT PresentationTRANSCRIPT
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Angiostatin: A Novel Angiogenesis InhibitorThat Mediates the Suppression of Metastases
by a Lewis Lung Carcinoma
Michael S. O’Reilly, Lars Holmgren, Yuen Shing,Catherine Chen, Rosallnd A. Rosenthal,
Marsha Moses, William S. Lane, Yihai Cao, E. Helene Sage, and Judah Folkman
Cell, Vol. 79, 315-328, October 21, 1994
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Lung carcinoma implanted subcutaneously into mice.Allow to grow to 1500 mm3
Removed (or not) and wait 15 daysLook for metastases to lung
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Same experiment, but now treat with serum from tumor-bearing animal
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Same experiment, but now treat with serum or urine from tumor-bearing animal
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Named this protein Angiostatin
Surprise! It’s a fragment of Plasminogen
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Named this protein Angiostatin
Surprise! It’s a fragment of Plasminogen
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