anesthesia and the beach chair position...2. to be aware of potential cerebral monitoring options....
TRANSCRIPT
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Anesthesia and the beach chair position
Paul PictonAssociate ProfessorSenior Associate Chair of Clinical Affairs and QualityUniversity of Michigan Medical School, Ann Arbor
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Disclosures
NIH UL1TR000433
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Objectives1. To understand the potential impact of cerebral
hypoperfusion for patients anesthetized in the beach chair position.
2. To be aware of potential cerebral monitoring options.
3. To understand the various influences on cerebral oxygenation for patients anesthetized in the beach chair position.
4. To be aware of the latest research concerning patients at potential risk of cerebral hypoperfusion under anesthesia.
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Chiang AC, et al. J Bone Joint Surg 2012
Demographics
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Catastrophic neurological injury• 1 case visual loss / opthalmoplegia
Bhatti MT, et al. Anesth Analg 2003• 4 cases severe CNS injury
Pohl A, Cullen DJ. J Clin Anesth 2005• 8 cases stroke reported in a survey of ASESS
Friedman DJ, et al. Orthopedics 2009• 24% cervical cord injury recorded in closed claim data base occurred in
BCPHindman BJ,et al. Anesthesiology 2011
• 1 case hemiplegic strokeDrummond JC, et al. Anesth Analg 2011
• 8 cases severe neurological injury (unreported) discussed in editorialMurphy GS & Szokol JW. Can J Anesth 2011
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Abnormal circle of Willis
Drummond JC, et al, Anesth Analg 2011
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J Clin Anesth 2005, 17(6):463-469
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Autoregulation
Drummond JC, Patel PM. Neurosurgical anesthesia. In: Miller RD, Cucchiara RF, Miller ED, Jr., et al., eds. Anesthesia, 5th ed. Philadelphia: Churchill Livingstone, 2000:1903-5.
Drummond JC. Anesthesiology 1997;86:1431-1433
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Autoregulation is impaired in the beach chair position
Laflam A. et al. Anesth Analg 2015
Prospective observational, LDC vs BCP, autoregulation measured by Cox, n=218
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No relationship between pre-op BP and LLA in the beach chair position
Laflam A. et al. Anesth Analg 2015
Prospective observational, LDC vs BCP, autoregulation measured by Cox, n=218
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“Syphon” vs “waterfall”
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Beach chair position and EEG evidence of ischemia
Gillespie R. et al. J Bone Joint Surg Am. 2012;94:1284-90
Prospective, controlled hypotension (90-100mmHg SBP), n=52
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MAP and safety?
Pin-on P, et al. Anesth Analg 2013, 116(6):1317-1324
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Summary 11) Catastrophic neurological injury has occurred with BCP2) Lower limit of autoregulation likely much
higher than 50mmHg and has wide inter-individual variability
3) Autoregulation is impaired in beach chair position
3) Correct for hydrostatic gradient
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Monitoring
Nelson T and Picton P. Chapt 26. In: Case Studies in Neuroanesthesiaand Neurocritical Care, 2011.
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Near infrared spectroscopy (NIRS)
Casati A et al Minerva Anestesiol 2006;72:605-25
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Cerebral desaturation (measured by NIRS) and neurologic injury
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Summary 2
1) rSO2 provides a non-invasive continuous measure of cerebral oxygenation 2) It is far from perfect!3) A decrease from baseline of 20% associated with neurological injury
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Cerebral desaturation in the beach chair position
Murphy GS, et al. Anesth Analg 2010, 111(2):496-505
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Increased Oxygen Administration Improves Cerebral Oxygenation in Patients
Undergoing Awake Carotid Surgery
Stoneham MD, et al. Anesth Analg 2008;107:1670-5
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The influence of basic ventilation strategies on cerebral oxygenation
Picton P, et al. J Clin Monit Comput 2010;24:421-425Picton P, et al. Br J Anaesth, 2012 Feb; 108 (2):326-7
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Inspired oxygen fraction and end tidal carbon dioxide during CEA with GA
Picton P, et al. Anesth Analg. 2010 Feb 1;110(2):581-7
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End tidal carbon dioxide in the beach chair position
Murphy G S et al. Brit J Anaesth 2014, 113:618-27
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Summary 3
1) BCP with GA results in cerebral desaturation2) Small increases in CaO2 may make a significant difference to under-perfused brain 3) Increasing FiO2 results in a measurable improvement in cerebral oxygenation4) Modulating PaCO2 may change cerebral oxygenation
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Anesthetic choice
Picton P, Deakin CD. Trauma Critical Care 2007 (2):1-22
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Beach chair position and anesthetic choice
Jeong H, et al. Anesthesiology 2012, 116(5):1047-1056.
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Cerebral oxygenation, ventilation strategy and anesthetic choice
Picton P et al. Anesthesiology 2015
Prospective within-group evaluation of ventilation strategy with randomized comparison of anesthetic choice, n=56
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Blood pressure and anesthetic choice in beach chair position
Picton P et al. Anesthesiology 2015
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Blood pressure and anesthetic choice in beach chair position
Picton P et al. Unpublished data
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Blood pressure and anesthetic choice in beach chair position
Picton P et al. Unpublished data
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Which vasoactive drug?
Meng L. et al. Brit J Anaesth 107 (2): 209-17 (2011)
PE EPH
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Which pressor / inotrope?
Meng L. et al. Brit J Anaesth 108 (5): 815-22 (2012)
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Summary 41) Anesthetic agents have differing effects on brain circulation and metabolism2) Choice of agent for patients at risk of cerebral hypo-perfusion is under investigated3) BCP related cerebral desaturation is attenuated by normocarbic hyperoxia and moderate hypercarbia – independent of anesthetic agent4) Ephedrine may have advantage over phenylephrine
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High risk patients?
Trentman TL, Fassett SL, Thomas JK, et al. Can J Anesth 2011; 58
Retrospective, GA ETT, BCP, n=384
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Risk factors for and risk of perioperative stroke
Mashour GA, et al. Anesthesiology. 2011 Jun;114(6):1289-96
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Patients with cerebrovascular disease
Vlisides P, Mashour GA, Picton P et al. Unpublished data
0
20
40
60
80
100
120
140
160
180
200
Baseline POD1 POD2 POD3
ng/L
S100β
CVD
Control
Prospective observational study patients undergoing major surgery (supine), CVD vs matched controls, n=48
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Patients with cerebrovascular disease
Vlisides P, Mashour GA, Picton P et al. Unpublished data
0
1000
2000
3000
4000
5000
6000
7000
Baseline POD1 POD2 POD3
Com
posi
te S
core
-Te
st
Bat
tery
Timeframe
Cognitive Function Score Trends - CVD vs. Control
CVDControls
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Patients with cerebrovascular disease
Vlisides P, Mashour GA, Picton P et al. Unpublished data
0
1000
2000
3000
4000
5000
6000
Baseline POD1 POD2 POD3
Com
posi
te S
core
-Te
st B
atte
ry
Timeframe
Cognitive Function Score Trends - Desat vs. Non-Desat
Desat Group(N=6)
Non-DesatGroup (N=39)
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Tumor
Licox Probe
Excision Canal
PbrO2 vs rSO2 in normal human brain with changes in ventilation strategy
Picton P et al. NCT03128957
Recruitment underway
Jennifer Lucaj
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Conclusions• Surgeries requiring beach chair positioning increasing in frequency• Devastating neurological sequelae in healthy patients have been
reported• Lower limit of autoregulation?• Allow for hydrostatic gradient and keep the blood pressure up• No widely agreed monitoring standard• Increasing FiO2 and ETCO2 results in a measurable improvement in
cerebral oxygenation for patients anesthetized in the beach chair position
• Anesthetic agents have differing effects on the brain but there is no proven benefit of one approach over another for patients in BCP
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Thanks to
NIH UL1TR000433
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Thanks to
George A. Mashour, MD, PhD
Andrew Dering, MBChB, FRCA
Mary Neff, CRNA Bruce Miller, MD, MS
Amy Shanks, MS,PhD
Michelle Housey, MPH
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Thanks to
Phil Vlisides, MD Magnus Teig, MBChB, FRCA
Amy McKinney, MA Jason Heth, MD