and tongue analysis the role of fingernail · · 2013-07-12the role of fingernail and tongue...
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Copyright. Chi‟s Enterprise, Inc.
The Role of Fingernail
and Tongue Analysisand Herbal Practice
PREVENTIVE METHODS DEVELOPED
FROM OVER 10,000 PATIENTS‟ RECORDS
Tsu-Tsair Chi, PhD
November 18, 2012 – Mt. Pleasant, MI
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LUNULA
TEETH MARKS
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• 2010 Hardcover edition
• Over 120 color pictures
2008 Edition
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COLOR
VITALITY
MOISTURE
SHAPE
COATING
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Tongue Color
1. Pink tongue
2. Pale tongue
3. Red tongue
4. Dark red/Purple
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Pink Tongue:
Normal
Light coating
on root of the
tongue
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Pale Tongue:
Anemia
Shiny areas on
tongue: Anemia
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Red Tongue:
Fever, Heart,
Infection
Spiky tongue:
Real fever
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Dark Red or
Purple Tongue:
Blood stasis,
Serious
1
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LUNG
TONGUE DIAGNOSIS
GALLBLADDER
LUNG
STOMACH(GI)
SPLEEN
HEART
KIDNEY
LIVER
LIVER
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HEART
Elongated
Tongue
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STOMACH
ULCER
Cracks on
tongue
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Teeth Marks
Hypoglycemia
Lung
White Coating
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Purple Dots: Blood Stasis
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SPIKY TONGUE
• Tip – Heart/Lung
• Side – Liver/Gallbladder
• Center – Stomach/Intestine
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Roadmap-like Tongue
Younger People:Deficiency of Blood,
Hormone and Chi
Older People:Digestion, Lack of
stomach acid
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FEVER
Spikes
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Inflammation Tongue Ulcer
2
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Tongue Movement vs. Diseases
• Stiff tongue and movement not easy
– Stroke or cognition
• Deviated tongue
– Whiplash, heavy metals, and stroke
• Tongue shrinks and is difficult to stick out
– Very serious condition
• Unable to control tongue, slow movements and/or tongue hangs out:
– Low IQ (since childhood) or stroke
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Deviated
Tongue
Whiplash
Heavy Metals
Stroke
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Tongue Coating
• Light white: Normal
• White: Lung
• Yellow: Stomach
• Black: Digestion, Kidney, etc.
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• Root / No Root
• Wet / Dry
• Greasy / Not Greasy
• Grow / Reduce
• Thick / Thin
Distribution of Coating
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Yellowish/White
Coating
FEVER or
LOCAL
INFLAMMATION:
Stomach
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Black Coating
• High fever
• Dehydrated
• Chronic infection
• Black/brown keratosis cell
• Digestion and Kidney
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DIGESTION
Black Coating
KIDNEY
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LIVER
Black, Dry,
Spiky Coating
3
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KIDNEYS
Green/Grey
Coating
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Mirror-Like Tongue• No coating
• Red color (thirsty, heavy chest, nauseous)
– stomach and gallbladder condition
• Serum albumin low
• Tongue cell metabolism retarded
– Digestion stopped
• Electrolyte imbalance
• Serious health condition
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GALLBLADDER
Red, dry,
cracking tongue
STOMACH
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Mirror-Like Tongue (Slippery)
Low serum
albumin
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Autoimmune
Disease, etc.
SNOW-LIKE
COATING
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Coating Location
• Whole tongue: Stomach and Liver.
• Tip (outside): Stomach initiative.
• Roots (inside): Stomach and Intestine
accumulation
• Left side: Inner Organs (difficult to treat)
• Right side: Outside Organs (muscles)
• No root: Stomach, kidney, spleen (serious)
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Coating with
No Root
Serious
Condition
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Peeling
Coating
Illness becomes
serious
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Coating in
Center
Inner organs
problem
4
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Coating on
Left Side
Dangerous
condition
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SHAPE OR
GROWTH
CHANGE
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NAIL CLUBBING
Caused by low oxygen levels in
the blood
Sign of:
• Heart problem
• Lung disease
• Cancer
• Parasites
• Digestive
problem
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KOILONYCHIA (spoon nails)
Anemia
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Nail growth is
interrupted by
severe illness
(heart attack) or
malnutrition
BEAU’S LINES
Horizontal indentations across the nails
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PITTING
• Psoriasis
• Chronic
Dermatitis
• Alopecia
areata
(hair loss)Small
depressions
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Psoriasis
Injury
Thyroid
disease
Fungal
disease
Drug
reactions
ONYCHOLYSISNail separates from nail bed
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COLOR
CHANGE
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TERRY’S NAILS (White nails)Opaque nails with a dark band on tip
Cancer
Congestive
Heart failure
Diabetes
Liver disease
(cirrhosis)
Auto-immune
disease
5
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Kidney
Disease
MUEHRCKE’S LINES
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Dark
longitudinal
streak(s)
• Melanoma
• Benign
nevus
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HALF and HALF NAILS
Renal Failure
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RED
LUNULA
Heart Disease
Systemic Lupus
Erymathosus
(SLE)
Rheumatoid
Arthritis
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AZURE LUNULA
Silver poisoning, Wilson‟s disease,
quinachrine therapy
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Lung/Heart (> 50-60%)
Nail Clubbing Ear Crease
Heart (89%)
Cardiovascular Markers
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Heart DiseaseTip of tongue is red, ear crease, nail
clubbing, lunulae on pinky
Poor Circulation
Lack of lunulae, cold hands & feet,
numbness of the limbs (If the condition
improves, the lunulae should reappear)
Atherosclerosis Vertical ridges
Peripheral Artery
DiseaseCentral nail canal (“fir tree” abnormality)
Stroke/Aneurysm Cherry angiomas on forehead
Heavy Metals
Protruding blue veins and/or red/black spots
underneath the tongue. Sometimes there is a
metallic taste.
Cardiovascular Symptoms
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Red dots on tip of tongue
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Earlobe crease and cardiovascular risk
Chronic circulatory problems allow the vascular
bed in the earlobe to collapse, causing the crease.
1982 study: An earlobe crease plus chest pain,
etc. predicts a heart attack 89% of the time.
Cardiac symptoms without an earlobe crease only
predicts 10% of heart attack cases.
1991 study: patients with diagonal earlobe
creases had higher cardiac mortality rate and
higher number of cardiac events.
6
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Nail Clubbing – Lung/Heart
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Nail Clubbing and Heart Disease
Source: Journal of the American Academy of Dermatology. 2005; 52(6): 1020-28
Hemiplegia
• Paralysis of half of body
• Of 87 patients, 13.8% had clubbing on the
affected side
Infective Endocarditis
• Inflammation of heart lining
• Of 60 patients, 50% had bilateral clubbing
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Lunula on the pinky
Heart Condition
Horizontal ridges
Horizontal Ridges: Heart Condition
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Central Nail Canal
“Fir Tree” abnormality
Peripheral Artery Disease
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Stroke/AneurysmCherry Angiomas on Forehead
• Cherry angiomas on
forehead,
• Family history of
stroke/aneurysm, and
• Hypertension
Risk is 23 = 8x higher
than average people
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Salvia, Carthamus, Paeonia and
Ligusticum Extracts
1991. Japan Health Department.
Symptom 2 weeks 4 weeks 6 weeks 8 weeks
Headache 38.5 69.2 72.7 91.7
Dizziness 40.0 65.0 --- 66.7
Cardiac Flutter 57.1 71.4 75.2 80.0
Cold Hands/Feet 12.5 37.5 --- 53.3
Numb Hands/Feet 11.1 50.0 --- 55.5
on Cardiovascular Symptoms of 300 Patients
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Salvia, Carthamus, Paeonia, and Ligusticum
Extracts on Cardiovascular Patients (30days)
28.926.6
38.1 36.8 38.1
0
5
10
15
20
25
30
35
40
Journal of West China University of Medical Sciences. 1999;30:64.
Blo
od
vis
cosi
ty
Fib
rrin
ogen
Mic
roci
rcu
lati
on
Ind
ex o
f th
rom
bla
stro
gra
m
Red
blo
od
cel
l ag
gre
gat
ion
130 patients
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• Study from Washington University in St. Louis, MO
• Mitochondrial function decreases in aging cells,
allowing a reactive form of oxygen to leak
• Reactive oxygen causes damage to blood vessel walls
• The body mounts an immune response to repair this
damage
• Immune cells attract a form of cholesterol that sticks
to arterial walls, causing plaque and eventually
atherosclerosis
Aging cells may lead to arterial damage
and plaque
Source: Nature. June 2005, Vol. 435
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Hippophae and Rhodiola Extracts
for Heart, Lungs, Energy
• Mitochondrial efficacy to utilize oxygen and glucose for the production of energy (ATP)
• Repairs/Protects vascular endothelial cells from free radical damage (vascular cell damage contributes to cardiovascular disease) LD50 > 40 ml/kg
Reference: Townsend Letter. May 2011; 334.
7
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Hippophae and Rhodiola Extracts
TrilinoleinActive constituent of Hippophae
and Rhodiola Extracts
DHA
EPA
Eicosapentaenoic Acid (20:5)
Docosahexaenoic Acid (22:6)
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Hippophae and Rhodiola Extracts vs. CoQ10 on Heart, Lung and Energy function
Action Extracts CoQ10
Increases energy within
30 minutes+++
Protects vascular
endothelial cells from
damage
+++ +
Repairs and protect
DNA-damaged cells+++
Eliminates shortness of
breath+++
Relieves choking-like
symptoms+++
Reduces palpitations +++
Minimizes chest
pounding+++
Action Extracts CoQ10
Improves mitochondrial
efficiency+++ +++
Reduces lactic acid +++ +++
Lowers lactate
dehydrogenase (LDH)+++ +++
Reduces malondialdehyde
(MDA)+++ ++
Increases superoxide
dismutase (SOD),
glutathione (GSH)
+++ +++
Anti-hypoxia +++
Reduces cholesterol +++ ++
Reduces triglycerides +++ +
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ASPARAGUS EXTRACT CONTAINS:
• ORGANIC FOLATE(9 capsules or 3 bags contains > 400 g of organic folic acid)
• ASPARAGINASE
• ASPARAGOSIDE
• GLUTATHIONE
• VITAMIN B, C, E
• ORGANIC SELENIUM
• ORGANIC ZINC
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• The American Journal of Clinical Nutrition. 2002; 76(4):758-65.
• JAMA. 2002; 288:973-979.
39%
28%
0
5
10
15
20
25
30
35
40
Asparagus Extract reduces Cardiovascular
Disease Risk by Reducing Homocysteine Levels
Folic Acid Homocysteine
(4 months)(1 month)
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Xanthomas (eyelid plaque) may signal
Atherosclerosis, Ischemic Heart Disease,
Myocardial Infarction, High Cholesterol*
• 48% higher chance of myocardial infarction
• If present in those under 30 years old,
signals arterial plaque
*British Medical Journal. 2011; 343:d5497.
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88%80%
84%
65%
0
10
20
30
40
50
60
70
80
90
Wine Extract reduces cholesterol in
155 patients (3 months)
Ath
ero
scle
rosi
s In
dex
Tri
gly
ceri
des
To
tal
Ch
ole
ster
ol
%
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• Black- or blue-colored nails
• Dark, protruding veins under the
tongue with red/black spots
• Gum shows dark/blue lines
• Metallic taste in mouth
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Blue veins under
the tongue
Heavy metal
deposit in gum
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Silver and
Copper
Poisoning
Heavy metal
deposits
8
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• Oral chelating herbal supplement
• No Side Effects
• Does not strip essential trace elements.
• Safe for children (3 years and older) to take.
• Kidney patients can take with Asparagus
Extract and use with Bathdetox
• Removes heavy metals through urination and
fecal excretion
• Inexpensive
Smilax, Sargassum, Rheum and
Allium Extracts
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Smilax, Sargassum, Rheum and
Allium Extracts on Lead Toxicity
0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
1st day 10 days
(10 days is one course, 3 courses is a treatment period)
Usage: 3-4 capsules, 3 times a day.
Lea
d i
n U
rin
e (u
mo
le/L
)
0.725
0.097
110 Patients
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Smilax, Sargassum, Rheum and Allium
Extracts vs. EDTA: Chelating Power
Pb2+ Cd2+ Hg2+ Zn2+
EDTA ++++ ++++ — ++++
Extracts ++++ +++ +++ —
EDTA cannot recover liver damage caused by lead toxicity.
The herbal extracts recover liver damage and do not inhibit
hemoglobin biosynthesis.
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Children with Lead Toxicity Risk of ADHD
Smilax, Sargassum, Rheum and Allium Extracts
chelate lead in children safely and
reduces/eliminates associated symptoms.
• Loss of appetite
• Hyperactivity
• Irregular sleeping habits
• Temper tantrums
• Lack of concentration
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Smilax, Sargassum, Rheum, and Allium
Extracts on Lead Toxicity(68 children, ages 3-12)
0.24
0.12
0.0
0.1
0.2
0.3
Day 0 Day 14
g/m
L
2 weeks
Zinc level increased from 4.58 to 4.87 g/ml
Associated symptoms reduced
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0.4280.483
0.556
0.270.23
0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0 7 14 21 28
Mer
cury
in u
rine
(μm
ol/
L)
Normal mercury in urine is < 0.250 μmol/LMetal Flush does not remove essential trace elements and has no side effects
days
50 cases
Smilax, Sargassum, Rheum and Allium
Extracts remove Mercury
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Advantages of Smilax, Sargassum,
Rheum and Allium Extracts
• Easy administration
• Inexpensive
• No side effects
• Does not strip essential elements
• Children (ages 3 and
above) can take
• Kidney patients can
take with Asparagus
Extract and use with
Bathdetox
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Has a high chance for bypass surgery.
Protocol: Extracts of Salvia, Carthamus, Paeonia and Ligusticum + Asparagus Extract + Extracts of Smilax, Sargassum, Rheum and Allium
Earlobe creaseBlue Veins under Tongue
with Red / Black Spots
Heart (89%)
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Your kidneys must be in good condition before undergoing intravenous chelation.
When bubbles are present in the urine or edema is present in the legs, this indicates a kidney problem.
Protocol: •Asparagus Extract
•Extracts of Rosa and Lygodium
•Extracts of Smilax, Sargassum, Rheum and Allium
•Extracts of Eupatorium, Cinnamomum, and Atractylodes
Bubbles in the
urine
Leg Edema
9
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ANEMIA
Concave or
“spoon-like”
nails
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DEFICIENCY of
BLOOD,
HORMONE and
CHI
Roadmap-like
Tongue in Younger
People
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Functions of Angelica, Cyperus,
Astragalus, Salvia Extracts
• Improves anemia and malnutrition
– WBC, especially after
chemotherapy
– RBC, Hemoglobin
• Platelets (ITP) by 81%
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Red
spots
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Balances estrogen, testosterone, progesterone
90% PMS PAIN
Irregular menstruation (75%)
Abnormal uterine bleeding (93%)
Menopausal Syndrome (NHRT)
Promotes fertility in both women and men
Recommended for pre- and postmenopausal women as well as men
Hormone Balance, Menopause, PMS
Angelica, Cyperus, Astragalus, Salvia
Extracts
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Angelica, Cyperus, Astragalus and Salvia
Extracts on 280 Women with
Dysmenorrhea (3 months)
41.07
48.21
10.71
0
10
20
30
40
50
Effective Improved No Effect
Eff
ecti
ve
Rate
(%
)
Overall
Improvement
89%
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Angelica, Cyperus, Astragalus and Salvia
Extracts on 60 Women with PMS (3 months)
93.3396.55
100
50
60
70
80
90
100
110
Heavy PMS Intermediate
PMS
Light PMS
Eff
ecti
ve
Rate
(%
)
Overall Effectiveness:
96.67%
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Angelica, Cyperus, Astragalus and Salvia on
120 Menopausal Women (3 months)
Symptom % Reduced Symptom % Reduced
Hot Flash 87.37 Painful Intercourse 89.18
Fatigue 62.96 Palpitations 59.60
Headache 55.06 UTI 50.62
Irritability 43.01 Depression 32.26
Joint Pain 29.61 Insomnia 23.72
Malaise 21.63 Dizziness 17.86
Approximately 80% of women over 50 years old will
benefit from the hormone-balancing effect of Chi-F
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• In Women: Cysts, Fibroids, Endometriosis,
Fibrocystic breasts, Female organ cancer, etc.
• In Men: BPH, Prostate Cancer, Testicle
Cancer, etc.
• In Both Men and Women: Diabetes, Insulin
Resistance, Cardiovascular risk, Dementia,
Autoimmune conditions, Abdominal fat, etc.
90
10
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ESTROGEN
CANCERWEIGHTMANAGEMENT
SEXUALVITALITY CARDIOVASCULAR
HEALTH
AUTOIMMUNEDISEASE
HORMONESDIABETES
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Physical Markers of
Estrogen Dominance
• Red dots on the tongue
• Cherry angiomas on the abdomen
• White spots on the nail
• Facial Hyperpigmentation
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White
spots
Hormonal Imbalance
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Cherry Angiomas on Abdomen
• If > 10 to 15 large ones
– Men: Prostate Cancer risk
– Women: Breast Cancer risk
– Or Liver Cirrhosis in both men and women
94
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Facial Hyperpigmentation:
Estrogen dominance
Chloasma, Melasma
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Cherry angiomas on the Forehead
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Cyperus, Curcuma and
Astragalus Extracts
• Aromatase inhibitor for women and men( Estradiol, Estrone, Testosterone)
• Competes with estradiol at estrogen
receptors
• Belly Fat
• Also for Type II Diabetes patients (with
Diabend and OxyPower
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DHEA17-OH Pregne-nolone
Testos-terone
Estradiol
Estrone
Estriol
Pregnenolone
Cholesterol
Proges-
terone
Corticosterone
Aldosterone
17-OH
Progesterone
11-Deoxycortisol
Cortisol Cortisone
Aromatase
Androste-nedione
Aromatase
DHT
5- reductase
17-OH
estrone
16-OH dehydroepi-androsterone
16-OH androsterone
16-OH
estrone
2-OH
estrone
EXTRACTS/
DIM
Extracts of Cyperus, Curcuma, Astragalus
MECHANISM
EXTRACTS
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Extracts of Cyperus, Curcuma and
Astragalus reduces Estradiol
Postmenopausal Women with Fibroids/Cysts
74.52
38.84
0
20
40
60
80
Before 10 Days After
60 patients
Postmenopausal women: Estradiol level < 35 pg/ml
11
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Extracts of Cyperus, Curcuma and
Astragalus: Aromatase Reducer
• Recommended for pre- and
postmenopausal women
• Recommended for men
• Multiple applications for estrogen-
dominant and hyperaromatization
conditions
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Extracts of Cyperus, Curcuma and Astragalus
inhibit aromatase expression in ovarian and
endometrial tissue in rats
Ectopic
endometrium
tissue
Ovarian
tissue
Negative Control
No stains
Positive Control
Tremendous aromatase
expression
Extracts group after
28 days
Aromatase
expression inhibited
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Comparison of grayscale values of
aromatase expression in rat endometrial
and ovarian tissues
Group
Ectopic
endometrium
(mean + SD)
Ovary
(mean + SD)
Negative control 48.0 + 8.5 29.7 + 6.4
Positive control 108.9 + 29.03 149.8 + 33.86
Herbal extracts group
(28 days)34.7 + 5.2 47.0 + 9.19
Aromatase reduction
(Herbal extracts)100% 85.6%
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AROMATASE INHIBITORSProduct
Administration, Cost
Manufacturer
Approval DateIndication
ARIMIDEX
Oral, $220/month
AstraZeneca
12/27/1995
Breast cancer in
postmenopausal women
AROMASIN
Oral, $224/month
Pharmacia
10/21/1999
Advanced breast cancer in
postmenopausal women after
tamoxifen therapy
FEMARA
Oral, $225/month
Novartis
1/10/2001
Advanced or metastatic breast
cancer in postmenopausal
women
Extracts of Cyperus,
Curcuma, Astragalus
Oral, $45-$90/month
No side effects
Dietary
Supplement
Estrogen-related conditions
(cysts, fibroids, ovarian/breast/
prostate cancer, etc) in men
and women.
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57.6
34.1
8.20
10
20
30
40
50
60
Effective Improvement No Change
~ 5 months
Extracts of Cyperus, Curcuma and
Astragalus on 255 Patients with Ovarian
Cysts and Endometriosis
1994 study from Chang Hai Hospital in Shanghai, China
Overall Improvement Rate of 92% within a 5-month period.
%
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Extracts of Cyperus, Curcuma, Astragalus +
Extracts of Bolbostemma + Sea cucumber
on 60 patients with Uterine Fibroids
69.2
19.011.8
0
10
20
30
40
50
60
70
Effective Improved No Change
*Those with uterine fibroids over 5cm should add
Revivin and Angiostop for better results.
6 months
%
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Extracts of Cyperus, Curcuma and
Astragalus on 100 Patients with
Fibrocystic Breasts
60
30
100
10
20
30
40
50
60
Effective Improved No Change
• 90% improved in 6 months
• 94% of the pain associated with cystic fibrosis had disappeared
6 months
%
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Factors influencing risk of
Breast/Ovarian Cysts/Cancer in women
I. Long-term Hormone Stimulation
– Among women with fibrocystic breasts for
over 20 years, 17% developed breast cancer
II. Obesity/Belly Fat
III. Xenoestrogens
IV. Hyperaromatization
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I. Long-term Hormone Stimulation
• 40% women of childbearing age already
develop fibrocystic breasts
• 42%: First time breast cancer diagnosis at 65
years old
• 1 in 6 American women who reach 80 years
old develop breast cancer
Breast Abnormalities
12
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Dense Breast Tissue: Risk for Breast Cancer
• More than half of all women have dense breast tissue
• Risk for breast cancer is 5x greater in women with
dense breast tissue
• Senate Bill 791 (CA) – effective 4/1/2012
Requires that patients be informed of their breast
cancer risk if dense breast tissue is found in
mammogram
Breast Calcification: Precancer• Small clusters of breast calcification is an early warning
sign of breast cancer
• Should be treated immediately
Sources: Int J Bioinform Res Appl. 2010;6(4):418-34; Br J Cancer. 2010 Sep 8;103(7):1034-1039.
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Progesterone
• Listed as “Carcinogenic” under California‟s
Prop 65 since 1988
• A listed substance may be natural, synthetic or
even naturally produced in the body
• Progesterone products should have a warning
labelSource: NNFA Today. Sep 2004; 18(9)
Even bio-identical hormones may pose a risk
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HRT Increases Breast Cancer Risk
• England Study: If Estrogen + Progesterone are used
together
– 66% increase in breast cancer incidence
– ~15,000 more cases per year
• If only progesterone is used
– 22% increase in breast cancer incidence
• Total of 20,000 more breast cancer cases every year
Source: Family Physician. Sep 2003.
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II. Obesity and Cancer
• Breast cancer
– Larger tumor size
– Advanced grade
– Increased nodal
involvement
– Higher mortality
• Prostate Cancer
– More aggressive
tumors
– Higher recurrence
rate
Obese persons have high estradiol,
low testosterone levels
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Extracts of Cyperus, Curcuma and
Astragalus for Belly Fat
Aromatase converts testosterone into estrogen.
More estrogen means more fat accumulation,
especially in the belly, which has the highest
amount of aromatase. The herbal extracts reduce
aromatase and consequently reduces belly fat.
For weight loss, take with
Extracts of Raphanus, Crataegus, Alisma,
Garcinia, Paeonia and Tyrosine .
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III. Xenoestrogens
• Substances that mimic the effects of estrogen
• Attach to estrogen receptors and disrupt endocrine functions
• Common xenoestrogens: clouding agents, pesticides, phthalates in plastics, dyes
(Environmental Hormones)
Underdeveloped white seeds
in watermelons signify
presence of xenoestrogens
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Plasticizers: Xenoestrogens
DEHP, DINP, BBP, DBP
• Plasticizers as clouding agents
found in sports drinks, juices,
tea drinks, fruit jams or syrups,
and tablets or powders
• Causes cancer and damage to the reproductive
system, heart, kidneys and liver
• Men: Has feminizing qualities, reduces sperm
• Women: Early puberty, breast cancer risk
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Effect of Xenoestrogens on Men
• Reduces sperm count
– Only ~46 million/ml for men around 20 years old
(Avg 84 million/ml for men 30-50 years old)
– 1940s: avg was 60 million/ml. Now avg is 20 million/ml
• Lowers ejaculation
• Doubles testicular cancer risk
– rate has doubled in the last 40 years
• Increases male breast cancer
– 1973: 86 per 100,000 were twice at risk
– 1998: risk increased 1.08 times
– 2004: 1,600 cases of breast cancer diagnosed
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Hugo Rodier, MD, from Utah
recommends the herbal extracts for his
patients who are exposed to
xenoestrogens
Extracts of Cyperus, Curcuma and
Astragalus counteract the effects of
xenoestrogens by competing with
estrogen and binding to estrogen
receptors
13
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Testosterone Estradiol (E2)
Estriol (E3)
DHEA
Progesterone
Aromatase
Androste-
nedione
Aromatase
IV. Hyperaromatization of Testosterone
Estrone (E1)
Pregnenolone Cholesterol
Extracts of Cyperus, Curcuma, Astragalus
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People at risk for Hyperaromatization
have the following conditions:
– Overweight (or difficult to lose weight)
– Type 2 Diabetes
• Insulin Resistance Hypertension
• Cholesterol Triglyceride
• Family history of Diabetes
Source: Jonathan Wright, MD. “Bio-Identical Hormone Replacement Therapy:
Common Issues and Solutions.” Townsend Letter. Jan 2010.
(High estradiol, Lower Testosterone)
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Symptoms of Hyperaromatization
–Overweight
–Low libido
–Reduced muscle tone
–Gynecomastia
Source: Jonathan Wright, MD. “Bio-Identical Hormone Replacement Therapy:
Common Issues and Solutions.” Townsend Letter. Jan 2010.
(High estradiol, Lower Testosterone)
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Any type of Hormone Therapy
Increases Breast Cancer Risk
Risk keeps increasing with longer durations of
use and never tapers off
Estrogen + Progesterone Study
Years of use Risk
10 – 15 88% higher than non-users
15 – 20 Double than those using for 10-15 years
Source: American Association for Cancer Research. April 1, 2012.
Copyright. Chi‟s Enterprise, Inc.122
When on Hormone Replacement
Therapy, including Bio-identical
hormones, and birth control pills,
add Extracts of Cyperus,
Curcuma and Astragalus to avoid
hormone-related side effects
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Source: Townsend Letter. Aug/Sep 2010: 54-56.
“Women were more likely to be long-term breast
cancer survivors...if they had more estriol (E3)
than estrone (E1) and estradiol (E2)”
E3 > E1 + E2
Suzanne Somers‟ Interview with
Dr. Jonathan Wright
In any situation, make sure
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Jonathan Wright, MD Townsend Letter (Jan 2010)
• Estrogen Quotient (EQ)
– EQ > 1: preponderance of estriol, lower estrogen-related cancer risk
– EQ = E3 / (E1 + E2)• E3 > (E1 + E2)
• 2/16 Hydroxyestrogen Ratio
– 2/16 ratio < 2 is related to cancer risk in men, pre- and postmenopausal women on BHRT
Testosterone Estradiol (E2)
Estriol (E3)
DHEA
Progesterone
Aromatase
Androste-nedione
AromataseEstrone (E1)
2-OH estrone
16-OH estrone
CholesterolPregnenolone
DIM
I3C
Extracts of Cyperus,
Curcuma, Astragalus
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Red Dots on the Tongue: Prostate Problems
Estrogen and the Prostate
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Cherry Angiomas on Abdomen: Prostate Problems
14
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Causes of Abnormal Increase of
Estradiol Levels in Men
• Hyperaromatization of testosterone
• Impaired liver function
• Obesity – increases aromatase expression
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Extracts of Melia, Citrus,
Phellodendron and Salvia
Benign Prostatic
Hyperplasia (BPH)
Prostatitis
Hair Loss in men
Add Extracts of Cyperus, Curcuma and
Astragalus for best effects for men
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Extracts of Melia, Citrus, Phellodendron, Salvia
+ Extracts of Cyperus, Curcuma and Astragalus
for Prostate Problems
Benign
Prostatic
Hyperplasia
(BPH)
Prostatitis
Hair Loss in
men
DHEATestos-
terone Estradiol
Estrone
Estriol
Androste-
nedione
DHT
5-
reductase
Extracts of Cyperus,
Curcuma, Astragalus
Extracts of Melia, Citrus,
Phellodendron, Salvia
Aromatase
Aromatase
Progesterone
Pregnenolone Cholesterol
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Biopsy recommended for men
with PSA > 2.5
• 82% missed cases without biopsy:
men < 60 years old
• 65% missed cases without biopsy:
men > 60 years old
Sources: Patient Care. December 2003.
New England Journal of Medicine. 2004; 350(22):2239-46.
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Disadvantages of Biopsies
Instead watch for these physical signs
indicating high estrogen and possibly a high
PSA level:
Red dots on the root of the tongue
Cherry angiomas on the abdominal area
• Definite risk of spreading the cancer
• Painful and uncomfortable procedure
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Normal Testosterone Level
• Decreased depression
• Improved memory
• Adequate levels of DHT correlated with:
– Improved sexual function
– Less aggressive prostate cancer riskSource: Jonathan Wright, MD. BHRT Symposium. June 25, 2011.
To normalize Testosterone Level, take Extracts of
Cyperus, Curcuma and Astragalus with Extracts of
Melia, Citrus, Phellodendron, Salvia
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Ovarian Cysts, Ovarian Cancer Odds Ratio in the US
• 1:500 women develop ovarian cysts within 5 years
after menopause
• 0.2% develop into ovarian cancer
Breast Cancer Odds Ratio in the US
• 1:22 women 50 years ago
• 1:6 women over 80 years old (year 2000)
• Among newborn girls in 2010, 1:3 will get breast
cancer within their lifetime
Prostate Cancer Odds Ratio in the US
• 1:6 men
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FUNCTIONS
Extracts of Cyperus, Curcuma, Astragalus
• Fibrocystic breast Colon polyps
• Endometriosis Cervical cancer
• Ovarian cyst/PCOS Breast cancer
• Uterine fibroid Ovarian cancer
• Thyroid cyst Uterine cancer
• Kidney cyst Prostate cancer
• Liver cyst Testicle cancer
• Neurofibromatosis Lung cancer
• Type II Diabetes Reduces belly fat
• Acne Competes with xenoestrogens,
reducing their effects
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Estrogen related to
Diabetes and
Insulin Resistance
Extracts of Gymnema, Morus, Coptis, Astragalus
Extracts of Hippophae, Rhodiola
Extracts of Cyperus, Curcuma, Astragalus
15
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Hypoglycemia
• Tongue is red and has
teeth marks
• Since hypoglycemia is a
precursor to Diabetes, and
vice versa, it is important
to regulate blood glucose
levels
Those who have high iron levels in the blood are
not only likely to develop cancer but are 3 times
more likely to develop diabetes.
Teeth marks
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Insulin Resistance, Diabetes, PCOS
Dark, wrinkly
pigmentation
Acanthosis nigricans
Skin tags
80% Type 2 Diabetes risk
May also be a colon problem
Children: Fatty liver
50% chance colon polyps
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Extracts of Gymnema, Morus,
Coptis, Astragalus Functions
• Blood glucose
• Glucose tolerance
• Insulin receptor sensitivity
• Beta cells of pancreas to produce
more insulin
• Antioxidant
• Regulates lipoprotein metabolism
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Extracts of Gymnema, Morus,
Coptis, Astragalus
for Type II Diabetes (6 months)
Group Total CasesEffective
CasesEffective Rate
Diabend 195 133 68.2%
Control 30 2 7.0%
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Insulin Resistance
• Present in at least 1 in 3
men with below-median
serum testosterone
• Associated with
hyperaromatization and
estrogen excess
• If low or below-median
testosterone
(hyperaromatization,
test for insulin
resistance!
• Signs and Symptoms
Sugar or carbohydrate craving
Shaky without food
Obesity, especially belly fat
Skin tags
o 80% risk of Type 2 Diabetes
Osteoarthritis
o ~80% have metabolic syndrome
Source: Jonathan Wright, MD. “Testosterone Evaluation, Treatment, Safety.” BHRT
Symposium. Las Vegas, NV. June 24, 2011.
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Dangers of Excess Estrogen in Aging Males
Int J Cancer. 2006; 118(9):2123-31
Annals of the NY Acad Sci. 2006; 1089: 77-193
Minerva Endocrinol. 2006; 31(1):1-12
J Cell Biochem. 2007; 102(4):899-911
Reprod Toxicol. 2007; 23(3): 374-82
FASEB J. 2007 Nov 30 [Epub].
Basic Clin Pharmacol Toxicol. 2008 Feb; 102(2):134-8
• Double the stroke risk
• Heart Attack, Myocardial infarction risk
• Atherosclerosis chance
• Thrombus (blood clot) incidence
• Prostate cancer, BPH riskSources:
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Estrogen and Cardiovascular
Disease
Cherry
Angiomas on
Forehead
Stroke or
Aneurysm
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• Crack(s) on tongue
• Black line(s) on nails
• Yellow coating on tongue
• Roadmap-like tongue
• Geographic tongue (IBS, Crohn‟s disease)
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STOMACH
ULCER
Cracks on
tongue
16
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Yellow
Coating
Digestive
problems
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Stomach or Esophageal Problem
If GERD is
present
22 = 4x
chance
Auricle cyst
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Roadmap-like Tongue
Older People:Digestion, Lack of
stomach acid
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The stool will not often show if you have minor bleeding. Stomach bleeding is caused by acid and pepsin secretion. If you have this condition, digestive enzymes should not be used.
Black lines on the fingernails and a
crack on the center of the tongue
often indicate stomach bleeding.
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Deep crack Yellow coating
Case Study: R.S., 67 y/o/m, esophageal and stomach issues
Pale and
shiny
tongue
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Extracts of Paeonia,
Atractylodes, Poria(For teeth marks & crack in center of tongue)
Digestive Enzymes
Absorption
H. Pylori bacteria
Adjusts stomach/intestinal muscle
contractions
Balances stomach acid
Repairs stomach/intestine membrane
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Digestron on Digestive Problems
59.0%
29.1%
11.9%
0%
10%
20%
30%
40%
50%
60%
Effective Improved No Effect
952 cases
Extracts of Paeonia, Atractylodes and
Poria on Digestive Problems
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Extracts of Paeonia, Atractylodes and
Poria for Digestive Disorders
ConditionRate (%)
Effective Improved
Gastritis 65.7 28.6
Chronic Atrophic Gastritis 47.7 17.4
Gastric Ulcer 79.7 17.0
Duodenal Ulcer 69.5 28.8
Irritable Bowel Syndrome* 50.5 39.8
Diverticulitis/Colitis* 40.3 18.2
*GI Chi + Psoricaid + Digestron for IBS and Diverticulitis/Colitis
For GERD, take Digestron + Debile
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39-year-old male with
Stomach Cancer30% Stomach Cancer
is Stage IV
16% metastasized
stomach cancer is
HER2 +
Need Angiostop
(EGFR inhibitor)
– 35% prolongs life
17
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Stomach Cancer
Cancer patients:
Tongue has greasy coating
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Markers/Symptoms of Liver Problems
• Dark, branching veins
under the tongue
• Red or dark spots on the
sides of the tongue
(blood stasis spots)
• Thick and wide tongue
• Large cherry angiomas
on the chest and
abdominal area
• Spider veins on the
chest and abdomen
• Dark or red bands on
the tips of the nails
• Red palm
• Bloating, dry mouth,
bitter taste, fatigue
• “Panda eye” (dark
circle around eye)
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Dark, branching veins under the tongue
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Characteristic of Veins under the
Tongue and Liver Conditions
Liver condition (N) 2 veins >2 veins Thickness Width Length
Hepatitis (60) 90% 10% 5.21+0.31 3.34+0.21 5.45+0.30
Liver Cirrhosis (50) 26% 74% 3.08+0.27 3.78+0.30 5.62+0.1
Liver Cancer (40) 45% 55% 3.10+0.4 4.34+0.21 5.63+0.1
Fatty Liver (60) n/a n/a 3.18+0.27 3.34+0.31 5.71+0.42
Alcohol-induced Fatty Liver: SGOT (AST) level is two times
higher than SGPT (ALT) level. Both levels are moderate-high.
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4 or more veins
under the tongue
• Liver cirrhosis
• Liver cancer
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Cherry AngiomaAn indication that estrogen attacks
peripheral
blood vessels, causing an aneurysm
Metabolism of too much estrogen causes liver
problems
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Cherry angiomas and spider veins
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Cherry Angiomas on Abdomen
• If > 10 to 15 large ones
–Men: Prostate Cancer risk
–Women: Breast Cancer risk
–Or Liver condition in both men
and women
162
18
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Yellow skin (Jaundice)
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Red Palm and Hot
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Spider Veins/Skin itching
Liver Cirrhosis
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AST (SGOT) ALT (SGPT)
HEPATITIS VIRUS TITER
JAUNDICE BITTER TASTE
Extracts of Schisandra,
Bupleurum, Smilax
LD50: 12.50 g/kg
The herbal extracts stop Hepatitis C RNA
virus replication and expression in 6 days
Fatty Liver, Hepatitis, Liver Cirrhosis
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Hepatitis A and B, Fatty Liver Studies
• Hepatitis A and B patients: ALT (SGPT) levels in 47 cases by 73% in 3 months
• Fatty Liver: 100% effective in 7 cases
• Excellent for bloating, bitter and dry mouth, cherry angiomas, fatigue
167
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In vitro study (2002):
Extracts of Schisandra, Bupleurum,
Smilax on Hepatitis C
• The herbal extracts have been
proven to inhibit Hepatitis C
RNA virus replication and
expression in 6 days
• The herbal extracts do not have a
toxic effect on normal liver cells
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Frenula Cyst (Lower)
Colon/rectum condition
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Intestine/upper colon condition
Frenula Cyst (Upper)
19
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Serious condition
Multiple Frenula Cysts
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3 Factors of Colon Polyps
Those without gallbladder → high chance of
colon cancer
Factor Recommendation
Bowel
irregularityAmorphophallus, Angelica, Lycii Extracts
Excess bile
from liver
Schisandra, Smilax, Bupleurum Extracts
Mentha and Curculigo Extracts
Excess
estrogenCyperus, Curcuma, Astragalus Extracts
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Symptoms suggest estrogen affects liver and colon
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Extracts of Amorphophallus,
Angelica, Lycii
• Colon, Intestine Detoxifier
• Regular Bowel Movements
• Balances pH of intestines and
promotes good bacterial
growth
• Cholesterol, Weight Control
• Blood Glucose Regulation
• Healthier, Blemish-Free SkinLD50: 45 g/kg
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Dark
line(s)
on nails
Internal Bleeding
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Inflammatory Bowel Disease related to
Autoimmune Disorders
Studies show that the incidence of autoimmune
problems in people with Crohn‟s disease and
Ulcerative Colitis is greater than those without
these diseases.
For best results, take Extracts of Paeonia,
Atractylodes, Poria with
Extracts of Euphorbia, Sanguisorba, Phellodendron
for Crohn‟s disease and Ulcerative Colitis
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Geographic
Tongue
• IBS
• Crohn‟s disease
• Lung
• Sinus/allergy
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Extracts of Euphorbia,
Phellodendron and Sanguisorba
Colitis, IBS, Diverticulitis
For gastrointestinal infections,
Use immediately
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20
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KIDNEY PROBLEM -Black Tongue
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Horizontal white line(s) across the fingernail
Kidney problem
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Horizontal
white line
30-year-old
Male with
Proteinuria
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Proteinuria
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IgA Nephritis
Half-and-Half nails
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• Puffy face when waking up
• Foamy urine
• Teeth marks on tongue
• Edema in legs/ankles
• Dark color/puffy under eyes
• Half-and-half nails
• Horizontal white line or strips on nails
• Yellow or black coating on root of tongue
Signs of Kidney Problems
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Teeth Marks Foamy urine
Proteinuria
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Serious Leg Edema
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KIDNEY PROGRAM• Asparagus Extract
• Creatinine, Diuretic
• Cordyceps Extract
• BUN
• Extracts of Rosa, Lygodium, Smilax, Centella
• Proteinuria
• Extracts of Eupatorium, Cinnamomum,
Atractylodes
• Edema, BUN, Ereatinine, Skin
Itching
21
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• Diuretic Agent
• Creatinine levels
• Renal glomerulus re-absorption
• Kidney function
ASPARAGUS EXTRACT
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Cordyceps Extract on Kidney
Function of 349 Patients
Overall 85.9% improvement
24.37
15.26
5.23.5
12.413.5
2.89 3.140
5
10
15
20
25
BUN Creatinine Hemoglobulin RBC
Before
After
(mg/dl) (mg/dl) (g/dl) (m/mm3)
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Extracts of Rosa, Lygodium,
Smilax, Centella
Urinary Tract Infection Kidney Stones
Frequent Urination Prostate
Difficulty urinating Gout
Toxicity Study: 480 times of the regular
dose, in mice shows no toxicity
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Extracts of Rosa, Lygodium, Smilax and
Centella on Genitourinary Conditions
64.34%
19.78%15.88%
0
10
20
30
40
50
60
70
Effective Improved No Change
6,512 cases(3,880)
(1,288)(1,034)
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Source: JTCM. 2003; 44(4):311.
Condition N Effective Rate
Frequent urination 172 82.71%
Acute cystitis 984 71.95%
Vaginitis (Trichomoniasis and Candidiasis) 243 65.84%
Kidney stones 221 62.44%
ProteinuriaUrine protein > 3.58 g/L for 2 weeks
Serum albumin < 3.0 g/L, Edema
478 59.41%
UTI 1057 42.48%
Prostatis 288 21.53%
Extracts of Rosa, Lygodium, Smilax, and
Centella on 6,512 cases of
Genitourinary Conditions
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Rat
#
Dose
kg-1/d-1
Number of rat survivors
Staphylococcus
aureus
E.
Coli
Bacillus
pycyaneus
Streptococcus
pyogenes Type I
Saline 20 20ml x 7 2 1 1 2
Cephalexin 20 1mg x 7 14 13 12 14
Kidney Chi 20 54mg x 7 12 11 7 10
Kidney Chi 20 18mg x 7 10 10 7 7
Kidney Chi 20 6mg x 7 7 5 5 5
In vivo Antibacterial Study:
Extracts of Rosa, Lygodium, Smilax, Centella
vs. Cephalexin
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Those who have
frequent bladder infections
should take
Asparagus Extract with Extracts of
Rosa, Lygodium, Smilax, Centella
for excellent results
Great to have when traveling and also
to prevent sexual disease.
Make it part of your first aid regimen.
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Extracts of Eupatorium, Cinnamomum, Atractylodes
SKIN DIALYSIS FORMULA
Detoxifies through the skin without hurting the kidneys and liver
The herbal extracts can remove these biowastesthrough the skin: urea, creatinine, uric Acid, cAMP,
purine compounds, aromatic compounds, polyamines, indoles, phenols, myoinositol, sorbitol,
oxalic acid, etc.
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Monoaminoxidase
Kidney
Circulation
Na-,K-,Cl-
Increase
Electrolyte
Balance
Sweat Medium-sized Biowastes***
Urea
Excretion
Cyanate
Urea BUN
Kidney
Medulla
Osmosis
Water
Excretion
EdemaPoison
Body Balance
Lung
Function
Angiotensin I Angiotensin II
Ketone & Anti-Diuretic
Hormones
Norepinephrine
Urine
Reabsorption
Urine
Norepi-
nephrine
***One of the causes of fibromyalgia is the
accumulation of biowastes. These biowastes
can be removed through the blood (use Vein
Lite) or through skin dialysis using
Bathdetox.
Skin Dialysis Mechanism
22
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Extracts of Eupatorium,
Cinnamomum, Atractylodes
41%
26%
83%87%
77%
0
10
20
30
40
50
60
70
80
90
BUN Creatinine Proteinuria Edema/ Pain/
Skin Itching Fibromyalgia
Imp
rovem
en
t
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Case study: 36 y/o/m with Focal segmental
glomerulosclerosis (Autoimmune disease)
Half and half Nails
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For bladder/vaginal area infection
– Extracts of Rosa, Lygodium, Smilax,
Centella
For upper respiratory
(throat/esophagus) area infection
– Bamboo Extract
For gastrointestinal infection
– Sanguisorba, Phellodendron, Euphorbia
INFECTIONS
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Lyme Disease• Caused by tick-borne bacteria
Borrelia burgdorferi
• Regular treatment is through
antibioticsDeer tick
Erythema
migrans
Circular/spiral
skin rash
associated with
Lyme disease Rash becomes
bigger
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Lyme Disease Symptoms
• Categories
– Skin Musculoskeletal
– Respiratory Gastrointestinal
• Skin itches on the bitten area
• Nearby joint pain, then limb numbness and blurred vision
• Then the infection goes to the blood and the nervous system
Copyright. Chi‟s Enterprise, Inc.
Lyme Disease Protocol
Recommendation For infection in the…
Bamboo Extract Respiratory system
Extracts of Rosa,
Lygodium, Smilax,
Centella
Urinary system
Extracts of Eupatorium,
Cinnamomum,
Atractylodes
To remove toxins
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• Nail Clubbing
• Geographic tongue
• Vertical ridges on opaque nail
• White coating on tongue
• Tongue inflamed around the edges
Markers of Lung
Problems
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NAIL
CLUBBING
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Bilateral Nail clubbing and Lung Diseases
Pulmonary Diseases Total cases Cases w/ clubbing %
Cystic Fibrosis 73 73 100
Cirrhosis
(Hepatopulmonary syndrome)14 9 64.3
Hypersensitivity pneumonitis 82 44 53.7
Interstitial Pulmonary Fibrosis 588 289 49.2
Asbestosis 167 72 43.1
Mesothelioma 77 23 29.9
Bronchogenic carcinoma 111 32 28.9
Pulmonary arteriovenous malformation 93 18 19.4
Sarcoidosis 90 11 12.2
Tuberculosis 426 72 16.9
Source: J American Academy of Dermatology. June 2005; 52(6): 1020-28
23
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Geographic Tongue
Sinus allergy, Lung Problem
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White Coating
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Vertical ridges on opaque nails
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Tongue inflamed around edges
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Extracts of Hippophae and Rhodiola
for the Lungs
• Lung congestion
(as quickly as 20 mins)
• Anti-Hypoxia
• Energy, Anti-Fatigue
• Throat clearing
• Pulmonary and Brain edema
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23.4
26.4
30.6
20
24
28
32
Control 0.125 g/kg
Rhodiola
0.125 ml/kg
Extracts
Su
rviv
al t
ime
(min
s)
Anti-Hypoxia Effect: Herbal Extracts vs.
Rhodiola alone in mice
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BAMBOO EXTRACTAcute and chronic throat and lung
conditions
Cough with phlegm
Sore throat
Runny nose Asthma
Ear irritation in Children
LD50 > 20g/kg
FIRST AID for upper respiratory conditions
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Bamboo Extract + Cephalexin more
effective than Cephalexin alone
*Cephalexin alone is only 6.1% effective
Overall, Bamboo Extract + Cephalexin is 81.2% effective
for all age groups and duration of disease
AgeEffective
Rate
< 40 years old 100%
41-60 years old 81.2%
> 60 years old 32.8%
Duration of
disease
Effective
Rate
> 10 years 81.94%
< 10 years 78.1%
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Bamboo Extract for Oral Candida
• People with low immunity such as diabetes
patients, children, the elderly, HIV patients, long-
term steroid users, and cancer patients - More
prone to candida in the mouth and throat
• Antibiotics and/or pain medication are often
unnecessary.
• Instead they should take Bamboo Extract for
candida.
24
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Extracts of Astragalus,
Xanthium, Saposhnikovia
• ALLERGIC RHINITIS
• SINUSITIS
Take before the allergy season starts
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Extracts of Astragalus, Xanthium,
Saposhnikovia on Allergic Rhinitis
22.9
57.2
19.9
0
10
20
30
40
50
60
Effective Improved No Change
%
367 cases
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BRONCHITIS PNEUMONIA
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EMPHYSEMA
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• Only thumbs have
lunulae (80%)
• Physical signs
CANCER
Especially if 8 lunulae were present
and then disappear feel cold
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Only thumbs have lunulae
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Physical Signs to Determine Early
Signs of Cancer
TYPE OF
CANCERSYMPTOMS
Colorectal
Cancer
• Frenula cyst
• Shape of stool changes, sometimes with blood
• Soft, light-colored hair on the cheeks on adults
Stomach
Cancer
If the digestive symptoms suddenly change with
severe pain
Esophageal
Cancer
GERD patients who feel like food is stuck in the
throat or it goes down very slowly
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Physical Signs to Determine Early
Signs of CancerTYPE OF
CANCERSYMPTOMS
Breast and
Prostate
Cancer
• Red dots on tongue
• Lots of cherry angiomas (>10 to 15) on
chest, may also be Liver Cancer
Cervical
CancerVaginal bleeding after intercourse
Ovarian/
Uterine
Cancer
Sudden vaginal bleeding in postmenopausal
women
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Physical Signs to Determine Early
Signs of Cancer
TYPE OF CANCER SYMPTOMS
Kidney Cancer Urinary bleeding with no pain
Lung Cancer
• Nail clubbing with chronic dry cough
• Soft, light-colored hair on the cheeks
on adults
Lymphoma,
Leukemia
• Triangular nails
• Nail clubbing
Nasopharyngeal
Brain Cancer
Ear ringing on one side only (For brain
cancer: also headaches and blurred
vision)
25
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Hard lump about 2 inches
above or to the left of the navel
Stomach Esophagus/Stomach
Lump, thickening or wrinkle
on the auricle
2 1
3
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Not every RTK drug can target several
cancer processes simultaneously
• Angiogenesis
• Invasion
• Metastasis
• Proliferation
• Inhibition of apoptosis
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VEGFR(Avastin, Nexavar,
Sutent, Votrient,
Zactima)
PDGFR(Gleevec, Nexavar,
Sprycel, Sutent,
Votrient)
EGFR(Tarceva, Erbitux,
Herceptin, Iressa,
Tykerb, Zactima)
FGFR(Votrient)
Angiogenesis
Proliferation
Apoptosis
Lymphomagenesis
Tumor Vascular
Maturation
Mitogenesis
Cellular motility
Metastasis
Sea cucumber Extract can inhibit all 4 RTKs and
Associated Cancer Processes
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Sea Cucumber
Extract
Neo-Angiogenesis and RTK
Inhibitor
LD50 = 4.3g/kg orally in mice
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Inhibition of growth factor signaling
Inhibition of signal
transduction pathway
intermediates
Induction of
apoptosis
Cell
membrane
EGFR, PDGFR, VEGFR, FGFR
AKT /
RAS
Sea Cucumber Extract Mechanism
Nuclear
membrane
Inhibition of DNA’s
Topoisomerase2
Copyright. Chi‟s Enterprise, Inc.
Type of CancerVEGFR
(Avastin, Nexavar, Sutent,
Votrient, Zactima)
PDGFR(Gleevec, Nexavar,
Sprycel, Sutent, Votrient)
EGFR(Tarceva, Erbitux,
Herceptin, Iressa,
Tykerb, Zactima)
FGFR(Votrient)
Bladder
Bone
Brain (Glioma)
Breast
Colorectal
Esophageal
Gastric
Head and Neck
Kidney
Leukemia
Liver
Sea Cucumber Extract inhibits 4 RTKs, associated cancer types
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Type of Cancer
VEGFR(Avastin, Nexavar, Sutent,
Votrient, Zactima)
PDGFR(Gleevec, Nexavar,
Sprycel, Sutent, Votrient)
EGFR(Tarceva, Erbitux,
Herceptin, Iressa,
Tykerb, Zactima)
FGFR(Votrient)
Lung
Lymphoma
Melanoma
Meningioma
Myeloma
Nasopharyngeal
Ovarian
Pancreatic
Prostate
Thyroid
Sea Cucumber Extract inhibits 4 RTKs, associated cancer types
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4/11/2005 8/24/2005
Sea Cucumber Extract inhibits angiogenesis
as illustrated by thermal imaging
6/28/2005
Between 4/11/05 and 6/28/05, this 42-year-old female patient took no herbs and had a
positive mammogram and ultrasound. Beginning 6/28/05, patient took Sea Cucumber
Extract and results have been remarkable. It appears angiogenesis has receded, which is
the best possible outcome.- Medi-Therm Imaging
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Cancer recurrence rate increases after surgery
Breast Cancer
Study : 1,173 breast cancer patients
treated with surgery, 520 had relapse
(20% of premenopausal women relapsed
within 10 months after surgery).
Source: Intl J Surgery. 2005.
Colon and Lung Cancer
Lung and colon cancer surgery linked
to cancer recurrence.
Colon cancer patients who had surgery
had higher relapse rate than invasive
laparoscopy
Source: Lancet. 2002.
Chance of recurrence and metastasis after surgery:
• Within 2 years – 50%
• After 5 years – 5%
Recommendation: Use an angiogenesis inhibitor like Angiostop
before and after surgery to help minimize recurrence
26
Copyright. Chi‟s Enterprise, Inc.
Sea Cucumber Extract
• Multiple RTK targets (VEGFR, EGFR, PDGFR,
FGFR): more effective
• Also Topoisomerase2 inhibitor
• Used before and after surgery and biopsy to reduce
recurrence
• As a multiple RTK inhibitor, it can be first-line
treatment for better results
• Can be used by itself or with chemo for better and
faster results
• Reasonable cost compared to cancer drugs
Copyright. Chi‟s Enterprise, Inc.
Inhibition of growth factor signaling
Inhibition of signal
transduction pathway
intermediates
Induction of
apoptosis
Cell
membrane
EGFR, PDGFR, VEGFR, FGFR
AKT
Bolbostemma Ext
Sea Cucumber Ext
TARGETS FOR ANTI-CANCER AGENTS
Nuclear
membrane
Inhibition of G1-S transition
G1 S
Inhibition of DNA‟s
topoisomerase2
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Bolbostemma/Fritillaria ExtractInhibits G1-S transition in Cell Cycle
A disruption in the cell cycle can cause the cell to multiply
uncontrollably, forming a tumor.
LD50: 10.0g/kg
Uncontrolled cell replication is inhibited
Ensures that damaged or mutated DNA does not get passed on to daughter cells
Copyright. Chi‟s Enterprise, Inc.
(Lymphoma, Leukemia, Anemia, etc.)
Shell-Shaped/Triangular Nails
Bone Marrow or Blood Disease
Whenever you have these nails, check your Hgb, WBC, RBC levels
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NAIL CLUBBING
Cancer
• Lung cancer
(opaque nails)
• Lymphoma
• Leukemia
• Breast cancer
• Colon cancer, etc
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Nail clubbing and Cancer
Neoplastic DiseasesTotal # of
cases
# cases w/
clubbing%
Mesothelioma
(from asbestosis)77 23 29.9
Bronchogeneic carcinoma 111 32 28.9
Pleural Tumors 21 3 14.3
Lymphoma 40 6 15
Intrathoracic Hodgkin‟s in
children5 5 100
Nasopharyngeal carcinoma 90 6 6.7
Source: J American Academy of Dermatology. June 2005; 52(6): 1020-28
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Extracts of Hippophae and
Rhodiola
• DNA repair for cancer cells
• Oxygen (Cancer cells cannot grow in aerobic environments)
• Mitochondrial DNA repair
• More energy for cancer patients
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• Extracts of Hippophae, Rhodiola (DNA repair)
• Extracts of Salvia, Carthamus, Paeonia, Ligusticum (For cardiovascular conditions)
• Extracts of Cyperus, Curcuma, Astragalus (For estrogen-related problems)
• Lutein, Bilberry, Alisma, Cornus Extracts (Eye health, hearing, bones, hair)
• Asparagus Extract (Kidneys, immunity, heart)
Consumers believe genes and lifestyle affect aging more
than external products
69% of consumers reported the earlier one starts using
age prevention remedies, the betterSource: “„Cause‟meceuticals.” Natural Products Insider. July 18, 2011.
Copyright. Chi‟s Enterprise, Inc.
Vertical ridges on nails
• Aging
• Adrenals
• Kidneys
• Vitamin deficiency
• Peripheral blood
vessel disease
• Neurasthenia
27
Copyright. Chi‟s Enterprise, Inc.
Mitochondrial Dysfunction
• When mitochondrial function is low, lactic
acid cannot be converted to energy, causing
acidosis
• Not enough cell energy supply leads to:
– Muscle strength - Liver disease
– Retarded growth - Kidney failure
– Induced epilepsy/seizures - Sudden stroke
– Heart enlargement - Kidney failure
– Heart failure - Diabetes
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Extracts of Hippophae and Rhodiola promotes
DNA Repair for Anti-Aging, Healing
• Deficiencies in DNA repair show
– premature onset of neurodegenerative
age-related diseases
– shortening of lifespan
• OxyPower prevents DNA damage and
repairs damaged DNA
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Extracts of Hippophae and Rhodiola may
protect and repair damaged DNA (Comet Test)
Test shows K2Cr2O7-induced
damage of TK6 human
lymphoblast cells, evident
here as the comet tail
24 hours after the extracts
were added, DNA damage
was repaired, as seen by the
absence of the comet tail
Copyright. Chi‟s Enterprise, Inc.
Fingernail easily splits
• Adrenals
–Chi Energy
• Lack of stomach acid
–Digestron
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Vertical
ridges like
beads on a
string
OSTEOPOROSIS
ARTHRITIS
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Osteoporosis/Osteopenia
Thin Nails
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• Improves bone density
• Enhances bone calcium content
• Inhibits calcium loss from bones
• Does not affect estrogen levels
• Recommended for osteoporosis patients who
have or are at risk for estrogen-related
conditions such as cysts, fibroids, breast
cancer, etc
Extracts of Rehmannia, Corydalis,
Dioscorea, Lycium for Osteoporosis
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Extracts of Rehmannia, Corydalis,
Dioscorea, Lycium on Osteoporosis
54.17%
44.79%
1.5%
0
10
20
30
40
50
60
70
Effective Improved No Change
96 cases
Copyright. Chi‟s Enterprise, Inc.
• Pain, Migraine
• Dizziness
• Numbness
• Arthritis
• Blood Pressure
• Fibromyalgia
• Nervous System
• Muscle Ache
• Paralysis
• Intervertebral Disc
Herniation
• Calming effect
Extracts of Gastrodia, Angelica,
Ligusticum Functions
28
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Extracts of Gastrodia, Angelica, and
Ligusticum on 1,137 patients with
Neurological Conditions76.2
73.9
66.767.7
70.6
68.8 69.4
72.6
60
64
68
72
76
80
Pain Dizziness Fibromyalgia Tinnitus Lumbar Sciatica Cervical Lumbar Disc
Disease Vertebra Herniation
Source: Beijing Medical University. 1997.
Eff
ecti
ve
rate
(%
)
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• Burns/Lesions Infection
• Wrinkles/Acne Skin Cancer
• Psoriasis/Eczema
Copyright. Chi‟s Enterprise, Inc.
"The new remedy not only eases pain of burn injuries, according to proponents, but speeds healing, reduces scarring and drastically cuts the cost of saving lives. There is no need for bandages, no topical antibiotics and no sterile isolation. The conventionally treated skin was rough, scarred and marked by patches of excessive or reduced pigmentation. The herbal treated flesh was now "supple and unblemished."
Aloe, Coptis, Phellodendron Ointment
MEDICINE
“A Simpler Way to Save Lives”
Newsweek. May 7, 1990, page 68
Could a new medication from China change the world‟s approach to
treating burn injuries?
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Silvadene Whole Skin
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Aloe, Coptis, Phellodendron Extracts
(Scar-Free Ointment)
ENDORSED BY
JONATHAN WRIGHT, MD
Make this ointment part of the
FIRST AID regimen in
your home and workplace.
Copyright. Chi‟s Enterprise, Inc.
11 days after 15 days after
SILVADENE WHOLE SKIN
30 days after
Whole Skin for Burns
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Missed Nail
Diagnosiscould actually be
Squamous Cell
Carcinoma,
Melanoma
“Fungal Masquerades”
Richard K. Scher, MD,
World Congress
of Dermatology
February 2003
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MELANOMA
“Amelanotic melanoma occurs more often in the
nail than in the skin.”Richard Scher, MD from the Dermatology Times, Feb.2003, p. 30.
Copyright. Chi‟s Enterprise, Inc.
Black mole on
the palm or sole
of the foot:
High chance of
melanoma
29
Copyright. Chi‟s Enterprise, Inc.
Melanoma and Estrogen
Ref: Cancer Prev Res. 2012. 5(1): 82-8.
• Elevated estrogenlevels may be implicated in melanoma etiology
• Risk of melanoma was higher for patients who did not receive anti-estrogens
Melanoma (dark colored)
Cherry
Angiomas
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MyxomaSquamous Cell
Carcinoma
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Prevent Skin
Cancer• Avoid sun
exposure
• Extracts of Aloe, Coptis, Phellodendron
• Asparagus Extract (organic folic acid)
• AGG (Antioxidant)
• Sea Cucumber Ext
• Bolbostemma Ext
• Asparagus Extract
• Reishi Spore Extract
Skin Cancer
Protocol
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Extracts of Raphanus, Crataegus, Alisma,
Garcinia
Tyrosine and Paeonia Extract
Extracts of Cyperus, Curcuma, Astragalus
(for belly fat)
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Extracts of Raphanus, Crataegus,
Alisma, and Garcinia
• Removes fat by 51%
–If taken before meals
• Burns fat faster
–If taken before exercise
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ENERGY
Exercise: Consume Energy (ATP)
FOR BODILY
ACTIVITY
ATP ADP + P
(INHIBITION)
FAT DEGRADATION
Extracts of Raphanus, Crataegus, Alisma, Garcinia
Removes ADP, Promotes the fat-burning process
to control weight
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Tyrosine and Paeonia Extracts
• Increases metabolic rate
• Increases serotonin and norepinephrine levels
• Induces a happy feeling, reducing cravings
for foods and promoting faster fat burning
Extracts of Cyperus, Curcuma,
Astragalus for belly fat
• Reduces abdominal fat by inhibiting aromatase
• The belly has the highest amount of aromatase
Copyright. Chi‟s Enterprise, Inc.
Copyright © 2012 Chi‟s Enterprise, Inc.
Reproduction of this work in any form, in whole or in part, by any means,
electronic or mechanical, including photocopying, microfilming, and recording,
or by any information storage and retrieval system, without permission in
writing from Chi‟s Enterprise is strictly prohibited at the risk of legal action.
30