and prognosis classic complications, treatment … · classic complications, treatment and...
TRANSCRIPT
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Moderate to Severe TBI:Classic Complications, Treatment
and Prognosis
Peter Esselman, MD MPTProfessor and Chair
Department of Rehabilitation MedicineUniversity of Washington
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Prognosis: Glasgow Outcome Scale• 1 = DEAD• 2 = VEGETATIVE STATE
Unable to interact with environment; unresponsive• 3 = SEVERE DISABILITY
Able to follow commands/ unable to live independently• 4 = MODERATE DISABILITY
Able to live independently; unable to return to work or school
• 5 = GOOD RECOVERY Able to return to work or school
http://www.tbims.org/combi/gos/index.html 2017 2
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Prognosis• Predictors of poor prognosis (death, GOS 1-3)
– Older age (association present after age 40)– Low GCS– Absent pupil reactivity– Presence of major extracranial injury– Obliteration of third ventricle or basal cisterns on
CT scan• Influenced by Low/middle income or High
income country
2017 3
CRASH Trial, BMJ 2008 336:425-9.
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TBI Prognosis Calculator
2017 4Iorio-Morin C Clinical Neurology and Neurosurgery 142 (2016) 48-53.
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Functional Prognosis• Severe disability (according to GOS) unlikely
when– Time to following commands is < 2 weeks– Duration of PTA is < 2 months
• Good recovery (according to GOS) is unlikely when– Time to following commands is > 1 month– Duration of PTA is > 3 months– Age older than 65 years– MRI indicates bilateral brainstem injury
2017 5Zasler, Katz & Zafonte, Brain Injury Medicine: principles and practice, Demos Medical Publishing: New York. 2013
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Acute Management• Primary injury – physical damage caused by
the trauma• Secondary injury – caused by those processes
that follow the injury– Hypoxia– Hypotension– Cerebral edema– Metabolic abnormalities
For review see Chesnut RM, Crit Care Clin 20:25-55, 2004.
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Edema and Increased ICP
Hutchinson PJ Curr Opin Crit Care 2004;10:101-104
2017 7
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Elevated ICP Treatment• ICP treatment may be initiated at an upper
threshold of 20 - 25 mmHg• Treatment goal is to maintain adequate
Cerebral Perfusion Pressure (CPP)CPP = Mean arterial pressure (MAP) – ICP
• CPP guideline > 60 mm Hg, but can be individualized.
2017 8
For review see Chesnut RM, Crit Care Clin 20:25-55, 2004.
Recent update: Chesnut R Annals NY Academy of Sciences 1345: (2015) 99-107 and 1345: (2015) 74-82.
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Conceptual approach to managing severe traumatic brain injury“The goal is to determine if there is a risk of ischemia at a lower CPP”
Annals of the New York Academy of SciencesVolume 1345, Issue 1, pages 99-107, 16 JUL 2014 DOI: 10.1111/nyas.12483http://onlinelibrary.wiley.com/doi/10.1111/nyas.12483/full#nyas12483-fig-0001 2017 9
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Decompressive Craniectomy
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Treatment to Improve Outcome
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Amantadine• 184 subjects
– minimally conscious or vegetative• 4 -16 weeks after TBI• Amantadine or placebo for 4 weeks
– Followed for another 2 weeks• Results
– Amantadine accelerated the pace of functional recovery during active treatment as measured by the disability rating scale
2017 13Giacino JT N Engl J Med. 2012 Mar 1;366(9):819-26
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142017 14
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Hydrocephalus• Obstructive (Non-communicating)
• Blockage of the normal flow of CSF• Communicating (Most common in TBI)
• Impaired CSF absorption at arachnoid villa• Normal-pressure hydrocephalus is a form of
communicating hydrocephalus• Hydrocephalus ex vacuo
• Ventriculomegaly caused by atrophy
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Risk Factors for Hydrocephalus• Subarachnoid hemorrhage• Severe TBI• Skull fractures (depressed)• Infectious processes
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Diagnosing Hydrocephalus
• CT findings:• Enlarged lateral
ventricles• Normal or absent
sulci• Periventricular
lucency
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Diagnosis of Hydrocephalus
• Lumbar puncture (CSF Tap Test)• Assess patient for clinical improvement after
removal of 50 ml of CSF• CSF Drainage trial
• Prolonged CSF drainage with spinal catheter over 3-5 days
• Clinical improvement - increased predictive value of shunt success
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Shunting for Hydrocephalus
• Ventriculoperitoneal Shunt• Drains to peritoneum• Adjustable flow control valve that can be
adjusted non-invasively
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Shunt Complications• Shunt Failure
• Headache, irritability, confusion, lethargy• Proximal or distal obstruction
• Infection• Low grade fever, malaise, erythema over shunt• Staphylococcus epidermidis – most common
• Over drainage • Orthostatic headache, dizziness, diplopia, nausea
• Chronic subdural hematoma and hygroma2017 20
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Post-traumatic Seizures
• Immediate seizures– Occur within 24 hours
• Early seizures– Occur after 1 day and ≤7 days post-injury
• Late seizures– >7 days post-injury
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Seizure prophylaxis
• All patients with moderate to severe TBI should receive prophylaxis with Phenytoin for one week.
Temkin et al N Eng J Med 323:497, 1990
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Risk factors for Late Seizure• Risk factors for late seizures
– Biparietal contusions– Dural penetration with metal fragments– Multiple intracranial operations– Subdural hematoma with evacuation– Midline shift >5mm– Multiple or bilateral cortical contusions– Early seizure
Englander et al Arch PM&R 2003;84:365-73 2017 23
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Incidence of Post-traumatic Seizures• When does initial late seizure occur?
– 50-66% within the first year– 75-80% within 2 years
• Patients with moderate/severe TBI continue to have some increased long-term risk of late seizure
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252017 25
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CSF Leak• Rhinorrhea
– Fracture ethmoid air cells or frontal sinus– Diagnosis
• Glucose strips – unreliable• Beta-2 transferrin assay – sensitive and specific
– High resolution CT scan – used to localize – Increased risk of meningitis
2017 26
Oakley GM, Int Forum Allergy Rhinol. 2016;6:8–16.
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CSF Leak• Otorrhea
– Temporal bone fracture, dural tear and tympanic membrane tear
– Usually resolves spontaneously
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Pituitary Injury• Mechanism of Injury
– Infarction– Hemorrhage
• Risk factors– Fracture of middle cranial fossa– Severity of injury
2017 28
By Patrick J. Lynch, medical illustrator - Image:Skull and brain sagittal.svg, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=2893765
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Anterior Hypopituitarism• Anterior Pituitary
– Adrenocorticotropic hormone (ACTH)– Thyroid stimulating hormone (TSH)– Luteinizing hormone (LH)– Follicle stimulating hormone (FSH)– Prolactin– Growth hormone
JAMA 2007 298(12):1429-14382017 29
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Anterior Hypopituitarism• Prevalence after TBI 27.5%• Hormone replacement recommended in acute
phase of injury for– Adrenal insufficiency– Thyroid insufficiency
• No clear evidence for replacement of sex steroids in acute phase.
JAMA 2007 298(12):1429-1438Chigo E et. al. Brain Injury 19(9):711-724
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Posterior Hypopituitarism• Posterior Pituitary
– Storage organ for hypothalamic hormones oxytocin and antidiuretic hormone (vasopression)
• Posterior hypopituitarism– Central diabetes insipidus (with hypernatremia,
polyuria, polydipsia)• Unable to resorb free water• Treatment - Desmopressin (DDAVP)• Prevalence after TBI – 26% in acute phase and 7% in
long-term survivorsJAMA 2007 298(12):1429-1438Chigo E et. al. Brain Injury 19(9):711-724 2017 31
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SIADH• Syndrome of Inappropriate Antidiuretic
Hormone (SIADH)– Hyponatremia– Euvolemic– Hypotonic serum– Elevated urine osmolality and sodium– Treatment
• Fluid restriction• Do not correct quickly - risk of central pontine
myelinolysis
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Cerebral salt wasting• Hypovolemic hyponatremia
– Lethargy, nausea, seizures– Results from renal losses of water and sodium
• Treatment– Volume repletion– Salt tabs or other sodium correction
• Fluid restriction contraindicated
2017 33
John C Critical Care Nurse 32:2, April 2012Kirkman MA Neurocrit Care (2013) 18:406-416
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SIADH Cerebral Salt Wasting
Diabetes Insipidus
Volume Status * Euvolemic * Hypovolemic Euvolemic
Serum Sodium HyponatremiaUrine Hyper osmoSerum Hypo osmo
HyponatremiaUrine hyper osmo Serum Hypo osmo
HypernatremiaUrine hypo osmoSerum hyper osmo
Labs Serum osmo < 275Urine Na > 25U osmolality > 100
Serum osmo < 275UNa > 25 mEq/LU osmolality > 100
Uosm < 200Serum osmo >295
Underlying Driver Excess ADH -Increased renal reabsorption of water
Renal - decreased reabsorption of Na in volume contracted state
Decreased secretion of ADH leading to polyuria
Treatment -Free water restrict-Increase sodium intake
-Replete water volume and sodium-Restriction of fluids contraindicated
-Free water access-DDAVP 2017 34
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Cranial Nerve Abnormalities• Olfactory Nerve
– Incidence• 7% of all individuals with TBI• Moderate TBI - 19% • Severe - 25%
– Injury results in decreased smell and altered taste of food
– Can occur with mild TBI
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Cranial Nerve Abnormalities• Optic Nerve
– Occurs in up to 5% of individuals with TBI– Primary lesion
• Hemorrhage or tear of nerve– Ischemic neuropathy
• Circulation impairment
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Oculomotor Nerve (CN III)• Oculomotor nerve palsy
– Eye abducted with inability to adduct– Eyelid ptosis– Dilated and fixed pupil in complete palsy
• A blown pupil (fixed, dilated pupil) is sign of herniation
• Treatment– Patching/block visual input to eliminate diplopia– Surgery delayed 6-9 months
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From Wilson-Pauwels, Akesson and Stewart Cranial Nerves: Anatomy and Clinical Comments 1988.
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From Wilson-Pauwels, Akesson and Stewart Cranial Nerves: Anatomy and Clinical Comments 1988.
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Trochlear Nerve (CN IV)
• Superior Oblique muscle– Intorsion– Downward gaze
• Compensate by tilting head away from affected side
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LateralMedial
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From Wilson-Pauwels, Akesson and Stewart Cranial Nerves: Anatomy and Clinical Comments 1988.
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2017 43
From Wilson-Pauwels, Akesson and Stewart Cranial Nerves: Anatomy and Clinical Comments 1988.
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Abducens (CN VI)
• Lateral Rectus Muscle– Eye Abduction
2017 44
By Henry Vandyke Carter - Henry Gray (1918) Anatomy of the Human Body (See "Book" section below)Bartleby.com: Gray's Anatomy, Plate 785, Public Domain, https://commons.wikimedia.org/w/index.php?curid=541631
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Transverse
Longitudinal2017 45
• Temporal bone fractures• Transverse - unilateral loss
of vestibular function in > 50% patients
• Longitudinal - concussive injury to the membranous labyrinth
Vestibular Dysfunction
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Balance and Dizziness
• Benign Paroxysmal Positional Vertigo (BPPV)– Displacement of
otoliths– Dix-Hallpike Test– Epley maneuver– Vestibular
Rehabilitation
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Parnes, L. S. et al. CMAJ 2003;169:681-693 2017 47
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Fig. 6: Dix-Hallpike manoeuvre (right ear)
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Fig. 6: Dix-Hallpike manoeuvre (right ear)
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Dix-Hallpike• Nystagmus
– Onset has a brief latency (1-5 seconds)– Limited duration (typically less than 30 seconds)
• Head to right – tests right posterior canal• Head to left – tests left posterior canal
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Fig. 8: Particle repositioning manoeuvre (right ear)
Eply Maneuver
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Carotid Cavernous Sinus Fistula• What structures go through the cavernous
sinus?
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Carotid Cavernous Sinus Fistula• Symptoms
– Visual impairment– Supraorbital bruit– Exopthalmous– Orbital congestion– Oculomotor palsies– Trigeminal nerve involvement
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