Anatomy and PhysiologyThe Endocrine System

The endocrine system includes anything that secretes hormones directly into body fluids.

Endocrine glands include: the thyroid, parathyroid, adrenal, kidney, hypothalamus, pituitary, pineal, pancreas, ovaries, testes, and thymus glands.

The function of the endocrine systems is to regulate metabolic pathways (chemical rxns, electrolyte balance, membrane transport, reproduction, & digestion) by secreting hormones.

http://www.worsleyschool.net/science/files/hormones/mainpic.gif

Some terms: Hormone: a biochemical that affects a

specific metabolic pathway in another cell.

These are secreted into body fluids & blood.

These are mostly steroids and made from cholesterol but some are amines, peptides, proteins, and glycoproteins.

Target cells (or organs): cells or organs that receive the hormone (cell that is affected). These cells have binding sites (a.k.a. receptors) for specific hormones.

Hormones are placed in 2 groups: Steroid hormones and Nonsteroid hormones.

Steroid Hormones: lipid soluble, meaning they easily pass (diffuse) thru membranes. These are formed from cholesterol usually.

Nonsteroid hormones must bind to receptors of target cells (do not diffuse thru membranes). These are amines, peptides, proteins, and glycoproteins.

Hormonal Secretion Control:

This is done by negative feedback control.Mechanism that regulates the production

of hormones based on the accumulation of another substance along a metabolic pathway.

For example:The adrenal gland produces chemical A

which continues a pathway: A BC D E When E is accumulated, it prevents (or inhibits) the adrenal gland from producing A. This is a negative feedback mechanism.

http://faculty.clintoncc.suny.edu/faculty/Michael.Gregory/files/Bio%20102/Bio%20102%20lectures/endocrine%20system/cortisol.gif

http://www.google.com/imgres

The Endocrine Glands and Their Hormones

The Pituitary Gland: found in the base of the brain has 2 parts: anterior and posterior (based on the lobe

of the brain in which it is found). controlled by the hypothalamus (by releasing

hormones)

http://images.encarta.msn.com/xrefmedia/aencmed/targets/illus/ilt/T012393A.gif

The Pituitary Hormones:Anterior Pituitary Hormones:Growth Hormone (GH): stimulates

growth of cells (increase in size & cell division).

Prolactin (PRL): stimulates and sustains the milk production in new mothers.

Thyroid-Stimulating Hormone (TSH): controls thyroid gland secretions and is partially regulated by the hypothalamus.

Anterior Pituitary Hormones (cont’d): Adrenocorticotropic hormone

(ACTH): controls the hormone production of the adrenal cortex. Stress may increase ACTH.

Follicle-stimulating hormone (FSH) and luteinizing hormone (LH): are released in the gonads (testes and ovaries). These are called gonadotropins.

The Posterior Hormones:Antidiuretic hormone (ADH):

decreases urine production by regulating the amount of water the kidneys excrete; therefore, regulating [water] in body fluids.

Oxytocin (OT): considered an antidiuretic; it stimulates the uterine muscles to contract (causing contractions & birth), lactation b/c it stimulates milk-producing glands, and milk ejection.

The Thyroid Gland and its hormones: This is located on both sides of the larynx

and in front of the trachea. Thyroxine (a.k.a. T4 or tetraiodothyronine)

has 4 atoms of iodine and Triiodothyronine (a.k.a. T3) has 3 atoms of iodine (is 5 times stronger). Both regulate the metabolism of carbs (stimulate their use), proteins (stimulate their production), & lipids (stimulate their breakdown).

Calcitonin: not technically a thyroid hormone (b/c of the location of production). This regulates the [Ca] and [phosphate ions] in the blood.

Thyroid

http://stb.msn.com/i/D8/DF6013611CDFDC22A8FB8E28C1DFF.jpg

The Parathyroid Glands and their hormones: These 4 are found on the thyroid gland. These secrete parathyroid hormone (PTH):

increases blood [Ca++] and decreases blood [phosphate ion], affecting the kidneys, bones & intestines. This works with calcitonin and is regulated by the [ ] of these ions in the blood.

http://stb.msn.com/i/BD/F8BC26E3251ABD2F3FEA4607A1D47.jpg

The Adrenal Glands and their hormones: This is located on

top of the kidneys and contains 2 portions: adrenal medulla

(central portion)

adrenal cortex (outer portion).

http://www.massgeneral.org/cancer/crr/types/endocrine/images/adrenal_gland.jpg

The Adrenal Cortical Hormones: Aldosterone: regulates the [mineral]

in the blood, stimulating water retention and sustaining b.p. and volume.

Cortisol: a.ka. hydrocortisone, affects glucose, protein & fat metabolism.

Adrenal Sex Hormones: in males, a.k.a. adrenal androgens; in females, a.k.a. estrogens. These supplement sex hormones & stimulate gonad development.

The Adrenal Medulla Hormones:

Epinephrine (a.k.a. adrenaline) and norepinephrine (a.k.a. noradrenaline) are released simultaneously. These increase the heart rate, increase heart contractions, increase breathing rate, increase b.p., increase blood glucose levels, & decrease digestion causing the typical “fight or flight reaction”

The Pancreas and its Hormones: This is found by the

stomach and has 2 functions: exocrine gland (secretes digestive juices) and endocrine (releasing hormones).

The endocrine section contains groups of cells known as the Islets of Langerhans which contain alpha cells (secrete glucagon) and beta cells (secrete insulin).

http://www.pancreatic.org/atf/cf/%7BA69EE367-5C5C-4B26-A094-64E9EA47D990%7D/image001.jpg

The Pancreatic Hormones:Glucagon: produced by alpha cells;

stimulates the breakdown of glycogen and amino acids. It raises [blood sugar] and is regulated by a low blood sugar (hypoglycemia).

Insulin: produced by beta cells; stimulates the liver to make glycogen, promotes the transport of glucose into cells, stimulates protein synthesis and stimulates fat storage; thus, it decreases [blood sugar] and is regulated by a high blood sugar (hyperglycemia).

http://www.endocrineweb.com/images/sugar.gif

Blood Sugar Regulation:

Other Endocrine Glands

Pineal Glands: This is found in the

brain on the upper portion of the thalamus.

This secretes melatonin which regulates circadian rhythms (response to light and dark conditions of the environment. These rhythms dictate sleep patterns & seasonal cycles of fertility in some mammals.

http://training.seer.cancer.gov/module_anatomy/images/illu_pituitary_pineal_glands.jpg

Thymus Gland: This is found between

the lungs (shrinks with age).

This secretes thymosins which regulate the production & differentiation of white blood cells, specifically T cells (T lymphocytes)

http://www.besthealth.com/besthealth/bodyguide/reftext/images/Thymus_spleen.jpg

Reproductive Glands:Ovaries: produce estrogens &

progesteroneTestes: produce testosteronePlacenta: produces estrogens,

progesterone & gonadotropin

http://www.malecontraceptives.org/methods/images/heat.jpg

http://www.actionhealthinc.org/teenzone/images/female.jpg

http://www.nlm.nih.gov/medlineplus/ency/images/ency/fullsize/17122.jpg

Heart: produces atrial natriuretic peptide (stimulates urinary Na secretion).

Kidneys: produce erythropoietin (stimulates the production of rbc’s).

http://www.nhlbi.nih.gov/health/dci/images/heart_interior.gif http://www.healthline.com/blogs/health_observances/uploaded_images/kidney-713543.jpg

Stress and Health: Stress is defined as a

condition that causes change in the internal environment (a physiological response that alters homeostasis).

A stressor is a factor that causes stress.

http://www.google.com/imgres

Stress and Health: There are types of

stressors: physical which can be

temperature changes internally or externally, [O2] changes, injury, illness (infections), exercise, noise, etc.

psychological factors which include emotions, feelings (anger, joy, fear, grief, anxiety, depression, etc.), thoughts, losses, unpleasant and pleasant encounters, and sexual arousals/encounters.

http://www.google.com/imgres

https://www.google.com/search?q=diagram+of+human+stress+response&newwindow=1&tbm=isch&tbo=u&source=univ&sa=X&ei=NWIlVcDwI4mNsAXHhYD4CA&ved=0CB4QsAQ&biw=1280&bih=855#imgrc=v92lWgec94vrkM%253A%3BMoOxXUje15wdnM%3Bhttp%253A%252F%252Fwhole9life.com%252Fwp-content%252Fuploads%252F2014%252F10%252Fhuman-function-curve.jpg%3Bhttp%253A%252F%252Fwhole9life.com%252F2014%252F10%252Fgood-stress-vs-bad-stress%252F%3B968%3B851

Response to stress: These are physiological responses, called general stress syndrome, which is an adaptation to general stress.

This is controlled by the hypothalamus which activates fight or flight rxns (increases epinephrine output).

The physical responses include: Increased [blood glucose] levels increased heart rate increased rate of breathing increased blood pressureair passage dilation http://www.google.com/imgres

General Adaptation Syndrome

https://www.google.com/search?q=diagram+of+human+stress+response&newwindow=1&tbm=isch&tbo=u&source=univ&sa=X&ei=NWIlVcDwI4mNsAXHhYD4CA&ved=0CB4QsAQ&biw=1280&bih=855#imgrc=OW2cc5i_e2xHzM%253A%3BGz5Mloqea6S3kM%3Bhttp%253A%252F%252Fwww.mdpi.com%252Finsects%252Finsects-03-01271%252Farticle_deploy%252Fhtml%252Fimages%252Finsects-03-01271-g001-1024.png%3Bhttp%253A%252F%252Fwww.mdpi.com%252F2075-4450%252F3%252F4%252F1271%252Fhtm%3B1024%3B700

https://www.google.com/search?q=diagram+of+human+stress+response&newwindow=1&tbm=isch&tbo=u&source=univ&sa=X&ei=NWIlVcDwI4mNsAXHhYD4CA&ved=0CB4QsAQ&biw=1280&bih=855#imgdii=3G09VK6B3mmQ0M%3A%3B3G09VK6B3mmQ0M%3A%3Bqp_tTpcvg89SMM%3A&imgrc=3G09VK6B3mmQ0M%253A%3Bph-mFyPyuB-a5M%3Bhttp%253A%252F%252Fupload.wikimedia.org%252Fwikipedia%252Fcommons%252F5%252F55%252FHPA_Axis_Diagram_%28Brian_M_Sweis_2012%29.png%3Bhttp%253A%252F%252Fen.wikipedia.org%252Fwiki%252FStress_%28biology%29%3B789%3B671

https://www.google.com/search?q=diagram+of+human+stress+response&newwindow=1&tbm=isch&tbo=u&source=univ&sa=X&ei=NWIlVcDwI4mNsAXHhYD4CA&ved=0CB4QsAQ&biw=1280&bih=855#imgrc=SYp9r62BYd_5eM%253A%3B2-cbgCNM2fk70M%3Bhttp%253A%252F%252Fwww.nimh.nih.gov%252Fimages%252Fnews-items%252Fsternbergimmunebraindiagram_35700_2.jpg%3Bhttp%253A%252F%252Fwww.nimh.nih.gov%252Fnews%252Fscience-news%252F2008%252Ferrant-stress-immune-indicators-detected-in-depression-prone-womens-sweat.shtml%3B364%3B481

EFFECTS ON THE IMMUNE SYSTEM:

Other hormones are increased in output as well: glucagons, GH (both increase use of energy sources) and ADH (decrease urine output, conserving water, & maintaining blood volume).

In addition, cortisol is increased which decreases the # of lymphocytes (increasing risk of infection/illness by lowering resistance and increasing the risk of high blood pressure, GI ulcers and atherosclerosis).

https://www.google.com/search?q=diagram+of+human+stress+response&newwindow=1&tbm=isch&tbo=u&source=univ&sa=X&ei=NWIlVcDwI4mNsAXHhYD4CA&ved=0CB4QsAQ&biw=1280&bih=855#imgrc=dgrJp0mayMs__M%253A%3BAAGa8GNq2VQhzM%3Bhttp%253A%252F%252Fwww.healtheducation.uci.edu%252Fimages%252Fmindbody.jpg%3Bhttp%253A%252F%252Fwww.healtheducation.uci.edu%252Fstress%252Fmindbody.aspx%3B469%3B527

Effects of stress on the body http://www.apa.org/helpcenter/stress-body.aspx

Forty-three percent of all adults suffer adverse health effects from stress.

Seventy-five percent to 90% of all doctor's office visits are for stress-related ailments and complaints.

Stress can play a part in problems such as headaches, high blood pressure, heart problems, diabetes, skin conditions, asthma, arthritis, depression, and anxiety.

The Occupational Safety and Health Administration (OSHA) declared stress a hazard of the workplace. Stress costs American industry more than $300 billion annually.

The lifetime prevalence of an emotional disorder is more than 50%, often due to chronic, untreated stress reactions.

http://www.webmd.com/balance/stress-management/effects-of-stress-on-your-body

A.D.A.M.

http://www.pennmedicine.org/encyclopedia/em_DisplayAnimation.aspx?gcid=000099&ptid=17

http://www.pennmedicine.org/encyclopedia/em_DisplayAnimation.aspx?gcid=000040&ptid=17

http://www.pennmedicine.org/encyclopedia/em_DisplayAnimation.aspx?gcid=000048&ptid=17

Look up online or in text! Know the following:

dwarfism, gigantism, acromegaly, diabetes insipidus, goiters, Grave’s disease, cretinism, exophthalmos, tetany, Addison’s disease, Cushing’s syndrome, diabetes mellitus, ketosis, polyuria, polydipsia, polyphagia, insulin resistance, and menopause.

THE END!

This slide show was developed by Dana Halloran,

Cardinal Mooney High School, Sarasota, FL.

Used with her personal permission, adapted and amended by Rosa Whiting, Manatee School for the Arts, Palmetto, FL.