anaesthesia for congenital heart disease
DESCRIPTION
TRANSCRIPT
![Page 1: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/1.jpg)
Anesthesia for Congenital Heart Disease
![Page 2: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/2.jpg)
INCIDENCE• 7 to 10 per 1000 live births• Premature infants 2-3X higher incidence• Most common form of congenital disease• Accounts for 30% of total incidence of all
congenital diseases• 10% -15% have associated congenital
anomalies of skeletal, RT, GUT or GIT• Only 15% survive to adulthood without
treatment
![Page 3: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/3.jpg)
3
![Page 4: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/4.jpg)
CLASSIFICATION OF CHD
• L - R SHUNTS INCLUDE :– ASD →7.5% of CHD– VSD → COMMONEST CHD – 25%– PDA → 7.5% of CHD
• Common in premature infants
– ENDOCARDIAL CUSHION DEFECT - 3%• Often seen with trisomy 21
– AORTOPULMONARY WINDOW
![Page 5: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/5.jpg)
CLASSIFICATION OF CHD
• R – L SHUNTS– Defect between R and L heart– Resistance to pulmonary blood flow → ↓ PBF →
hypoxemia and cyanosis
• INCLUDE :– TOF – 10% of CHD, commonest R-L shunt– PULMONARY ATRESIA – TRICUSPID ATRESIA– EBSTEIN’S ANOMALY
![Page 6: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/6.jpg)
R – L SHUNTS
• GOAL → ↑ PBF to improve oxygenation– Neonatal PGE1 (0.03 – 0.10mcg/kg/min)
maintains PDA → ↑ PBF– PGE1 complications → vasodilatation,
hypotension, bradycardia, arrhythmias, apnea or hypoventilation, seizures, hyperthermia
– Palliative shunts → ↑ PBF, improve hypoxemia and stimulate growth in PA → aids technical feasibility of future repair
![Page 7: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/7.jpg)
Almost any anesthetic technicmay be used in any CHD patient
if
the anesthesiologist understands
•the pathophysiology of the lesion and
•the pharmacology of the drugs employed.
![Page 8: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/8.jpg)
ANESTHETIC MANAGEMENT
• Perioperative management requires a team approach
• Most important consideration is necessity for individualized care
• CHD is polymorphic and may clinically manifest across a broad clinical spectrum
![Page 9: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/9.jpg)
ANESTHETIC MANAGEMENT
• 50% Dx by 1st week of life; rest by 5 years• Child’s diagnosis & current medical condition
will determine preoperative evaluation• Understand the anatomic and hemodynamic
function of child’s heart• Discuss case with pediatrician and cardiologist• Review diagnostic & therapeutic interventions• Above will estimate disease severity and help
formulate anesthetic plan
![Page 10: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/10.jpg)
HISTORY & PHYSICAL
• Assess functional status – daily activities & exercise tolerance
• Infants - ↓ cardiac reserve → cyanosis, diaphoresis & respiratory distress during feeding
• Palpitations, syncope, chest pain• Heart murmur (s)• Congestive heart failure• Hypertension
![Page 11: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/11.jpg)
HISTORY & PHYSICAL
• Tachypnea, dyspnea, cyanosis
• Squatting
• Clubbing of digits
• FTT d/t limited cardiac output and increased oxygen consumption
• Medications – diuretics, afterload reduction agents, antiplatelet, anticoagulants
• Immunosuppressants – heart transplant
![Page 12: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/12.jpg)
LABORATORY EVALUATION
• BLOODWORK• Electrolyte disturbances 2° to chronic diuretic therapy
or renal dysfunction
• Hemoglobin level best indicator of R-L shunting magnitude & chronicity
• Hematocrit to evaluate severity of polycythemia or iron deficiency anemia
• Screening coagulation tests
• Baseline ABG & pulse oximetry
• Calcium & glucose - newborns, critically ill children
![Page 13: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/13.jpg)
LABORATORY EVALUATION
• 12 LEAD EKG– Chamber enlargement/hypertrophy– Axis deviation– Conduction defects– Arrhythmias– Myocardial ischemia
![Page 14: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/14.jpg)
LABORATORY EVALUATION
• CHEST X - RAY– Heart size and shape– Prominence of pulmonary vascularity– Lateral film if previous cardiac surgery for
position of major vessels in relation to sternum
![Page 15: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/15.jpg)
LABORATORY EVALUATION
• ECHOCARDIOGRAPHY– Anatomic defects/shunts– Ventricular function– Valve function– Doppler & color flow imaging direction of
flow through defect/valves, velocities and pressure gradients
![Page 16: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/16.jpg)
LABORATORY EVALUATION
• CARDIAC CATHERIZATION– Size & location of defects– Degree of stenosis & shunt
– Pressure gradients & O2 saturation in each chamber and great vessel
– Mixed venous O2 saturation obtained in SVC or proximal to area where shunt occurs
– Low saturations in LA and LV = R – L shunt– High saturations in RA & RV = L – R shunt
![Page 17: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/17.jpg)
LABORATORY EVALUATION
• CARDIAC CATHERIZATION– Determine shunt direction: ratio of pulmonary to
systemic blood flow : Qp / Qs– Qp / Qs ratio < 1= R – L shunt– Qp / Qs ratio > 1= L – R shunt
![Page 18: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/18.jpg)
Congenital Cardiac Surgery
• Preoperative medication– D/C diuretics and digoxin unless heart failure is
poorly controlled or digoxin is being used primarily for rhythm
– Continue inotropes– Continue prostaglandin infusions
![Page 19: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/19.jpg)
MONITORING
• Routine CAS monitoring
• Precordial or esophageal stethoscope
• Continuous airway manometry
• Multiple - site temperature measurement
• Volumetric urine collection
• Pulse oximetry on two different limbs
• TEE
![Page 20: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/20.jpg)
MONITORING
• PDA– Pulse oximetry right hand to measure pre-ductal
oxygenation– 2nd probe on toe to measure post-ductal
oxygenation
• COARCTATION OF AORTA– Pulse oximeter on right upper limb– Pre and post - coarctation blood pressure cuffs
should be placed
![Page 21: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/21.jpg)
ANESTHETIC MANAGEMENT
• GENERAL PRINCIPLES
Where:
Q = Blood flow (CO)
P = Pressure within a chamber or vessel
R = Vascular resistance of pulmonary or systemic vasculature
Ability to alter above relationship is the basic tenet of anesthetic management in children with CHD
RP
Q
![Page 22: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/22.jpg)
ANESTHETIC MANAGEMENT
P manipulate with positive or negative inotropic agents
Q hydration + preload and inotropes
However, the anesthesiologist’s principal focus is an attempt to manipulate resistance, by dilators and constrictors
![Page 23: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/23.jpg)
ANESTHETIC MANAGEMENT
• GENERAL CONSIDERATIONS– De-air intravenous lines air bubble in a R-L shunt
can cross into systemic circulation and cause a stroke
– L-R shunt air bubbles pass into lungs and are absorbed
– Endocarditis prophylaxis– Tracheal narrowing d/t subglottic stenosis or
associated vascular malformations
![Page 24: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/24.jpg)
ANESTHETIC MANAGEMENT
– Tracheal shortening or stenosis esp. in children with trisomy 21
– Strokes from embolic phenomena in R-L shunts and polycythemia
– Chronic hypoxemia compensated by polycythemia → ↑ O2 carrying capacity
– HCT ≥ 65% → ↑ blood viscosity → tissue hypoxia & ↑ SVR & PVR → venous thrombosis → strokes & cardiac ischemia
![Page 25: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/25.jpg)
ANESTHETIC MANAGEMENT
– Normal or low HCT D/T iron deficiency → less deformable RBCs → ↑ blood viscosity
– Therefore adequate hydration & decrease RBC mass if HCT > 65%
– Diuretics → hypochloremic, hypokalemic metabolic alkalosis
![Page 26: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/26.jpg)
Air Bubble precautions
• To prevent paradoxical air embolism• Remove all bubbles from iv tubing• Connect the iv tubing to the venous cannula while there is free flowing
in fluid .• Eject small amount of solution from syringe to clear air from the needle
hub before iv injection• Aspirate injection port before injection to clear any air• Hold the syringe upright to keep bubbles at the plunger end• Do not leave a central line open to air• Use air filters• ? No N2O.
![Page 27: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/27.jpg)
PREMEDICATION
a) Omit for infants < six months of ageb) Administer under direct supervision of
Anesthesiologist in preoperative facilityc) Oxygen, ventilation bag, mask and pulse
oximetry immediately availabled) Oral Premedication
• Midazolam 0.25 -1.0 mg/kg• Ketamine 2 - 4 mg/kg• Atropine 0.02 mg/kg
![Page 28: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/28.jpg)
PREMEDICATION
e) IV Premedication• Midazolam 0.02 - 0.05 mg/kg titrated in small
increments
f) IM Premedication• Uncooperative or unable to take orally• Ketamine 1-2 mg/kg• Midazolam 0.2 mg/kg• Glycopyrrolate or Atropine 0.02 mg/kg
![Page 29: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/29.jpg)
ANESTHETIC AGENTS
• INHALATIONAL AGENTS– Safe in children with minor cardiac defects– Most common agents used are halothane and
sevoflurane in oxygen– Monitor EKG for changes in P wave retrograde
P wave or junctional rhythm may indicate too deep anesthesia
![Page 30: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/30.jpg)
INHALATIONAL ANESTHETICS
• HALOTHANE– Depresses myocardial function, alters sinus
node function, sensitizes myocardium to catecholamines
MAP + HR CI + EF
• Relax infundibular spasm in TOF
• Agent of choice for HOCM
![Page 31: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/31.jpg)
INHALATIONAL ANESTHETICS
SEVOFLURANE
• No HR
• Less myocardial depression than Halothane
• Mild SVR → improves systemic flow in L-R shunts
• Can produce diastolic dysfunction
![Page 32: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/32.jpg)
INHALATIONAL ANESTHETICS
ISOFLURANE
• Pungent not good for induction
• Incidence of laryngospasm > 20%
• Less myocardial depression than Halothane
• Vasodilatation leads to SVR → MAP HR which can lead to CI
![Page 33: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/33.jpg)
INHALATIONAL ANESTHETICS
DESFLURANE
• Pungent not good for induction; highest incidence of laryngospasm
• SNS activation → with fentanyl HR + SVR
• Less myocardial depression than Halothane
![Page 34: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/34.jpg)
INHALATIONAL ANESTHETICS
NITROUS OXIDE
• Enlarge intravascular air emboli
• May cause microbubbles and macrobubbles to expand obstruction to blood flow in arteries and capillaries
• In shunts, potential for bubbles to be shunted into systemic circulation
![Page 35: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/35.jpg)
INHALATIONAL ANESTHETICS
NITROUS OXIDE
• At 50% concentration does not affect PVR and PAP in children
• Mildly CO at 50% concentration
• Avoid in children with limited pulmonary blood flow, PHT or myocardial function
![Page 36: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/36.jpg)
IM & IV ANESTHETICS
KETAMINE• No change in PVR in children when airway
maintained & ventilation supported• Sympathomimetic effects help maintain HR,
SVR, MAP and contractility• Greater hemodynamic stability in
hypovolemic patients• Copious secretions → laryngospasm →
atropine or glycopyrrolate
![Page 37: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/37.jpg)
IM & IV ANESTHETICS
KETAMINE• Relative contraindications may be coronary
insufficiency caused by:– anomalous coronary artery– severe critical AS– hypoplastic left heart syndrome with aortic atresia– hypoplasia of the ascending aorta
• Above patients prone to VF d/t coronary insufficiency d/t catecholamine release from ketamine
![Page 38: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/38.jpg)
IM & IV ANESTHETICS
IM Induction with Ketamine:• Ketamine 5 mg/kg • Succinylcholine 5 mg/kg or Rocuronium 1.5 – 2.0
mg/kg • Atropine or Glycopyrrolate 0.02 mg/kg IV Induction with Ketamine:• Ketamine 1-2 mg/kg • Succinylcholine 1-2 mg/kg or Rocuronium 0.6-1.2
mg/kg• Atropine or Glycopyrrolate 0.01 mg/kg
![Page 39: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/39.jpg)
IM & IV ANESTHETICS
OPIOIDS• Excellent induction agents in very sick children• No cardiodepressant effects if bradycardia avoided• If used with N2O - negative inotropic effects of
N2O may appear• Fentanyl 25-100 µg/kg IV• Sufentanil 5-20 µg/kg IV• Pancuronium 0.05 - 0.1 mg/kg IV offset
vagotonic effects of high dose opioids
![Page 40: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/40.jpg)
IM & IV ANESTHETICS
ETOMIDATE• CV stability• 0.3 mg/kg IV
THIOPENTAL & PROPOFOL• Not recommended in patients with severe cardiac
defects• In moderate cardiac defects:
– Thiopental 1-2 mg/kg IV or Propofol 1-1.5 mg/kg IV– Patient euvolemic
![Page 41: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/41.jpg)
ANESTHETIC MANAGEMENT
ANESTHESIA INDUCTION
• Myocardial function preserved IV or inhalational techniques suitable
• Severe cardiac defects IV induction
• Modify dosages in patients with severe failure
![Page 42: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/42.jpg)
ANESTHESIC MANAGEMENT
ANESTHESIA MAINTENANCE
• Depends on preoperative status
• Response to induction & tolerance of individual patient
• Midazolam 0.15-0.2 mg/IV for amnesia
![Page 43: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/43.jpg)
ANESTHETIC MANAGEMENT
• L - R SHUNTS :• Continuous dilution in pulmonary
circulation may ↑ onset time of IV agents
• Speed of induction with inhalation agents not affected unless CO is significantly reduced
• Degree of RV overload and/or failure underappreciated – careful induction
![Page 44: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/44.jpg)
ANESTHETIC MANAGEMENT
• L-R SHUNTS :– GOAL = SVR and ↑ PVR → L-R shunt
• PPV & PEEP increases PVR• Ketamine increases SVR• Inhalation agents decrease SVR
![Page 45: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/45.jpg)
ANESTHETIC MANAGEMENT
• R-L SHUNTS :– GOAL : PBF by SVR and ↓ PVR
PVR & ↓ SVR → ↓ PBF – Hypoxemia/atelectasis/PEEP
– Acidosis/hypercapnia HCT
– Sympathetic stimulation & surgical stimulation
– Vasodilators & inhalation agents → ↓ SVR
![Page 46: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/46.jpg)
ANESTHETIC MANAGEMENT
• ↓ PVR & SVR → PBF– Hyperoxia/Normal FRC– Alkalosis/hypocapnia– Low HCT– Low mean airway pressure– Blunted stress response– Nitric oxide/ pulmonary vasodilators– Vasoconstrictors & direct manipulation→ SVR
![Page 47: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/47.jpg)
ANESTHETIC MANAGEMENT
• R –L SHUNTS :– Continue PE1 infusions
– Adequate hydration esp. if HCT > 50%– Inhalation induction prolonged by limited
pulmonary blood flow– IV induction times are more rapid d/t bypassing
pulmonary circulation dilution– PEEP and PPV increase PVR
![Page 48: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/48.jpg)
ANESTHETIC MANAGEMENT
• COMPLEX SHUNTS :• Manipulating PVR or SVR to PBF will:
• Not improve oxygenation• Worsen biventricular failure• Steal circulation from aorta and cause
coronary ischemia
• Maintain “status” quo with high dose opioids that do not significantly affect heart rate, contractibility, or resistance is recommended
![Page 49: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/49.jpg)
ANESTHETIC MANAGEMENT
• COMPLEX SHUNTS :– Short procedures slow gradual induction with low
dose Halothane least effect on +ve chronotropy & SVR
– Nitrous Oxide limits FiO2 & helps prevent coronary steal & ↓ Halothane requirements
![Page 50: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/50.jpg)
ANESTHETIC MANAGEMENT
• OBSTRUCTIVE LESIONS• Lesions with > 50 mmHg pressure gradient +
CHF opioid technique• Optimize preload improves flow beyond
lesion• Avoid tachycardia ↑ myocardial demand & ↓
flow beyond obstruction• Inhalation agents -ve inotropy & decrease
SVR worsens gradient & flow past obstruction
![Page 51: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/51.jpg)
Congenital Cardiac Surgery
• Cardiopulmonary Bypass– Differences from adult
• Lower temperatures (15-20 degrees C)
• Lower perfusion pressure (20-30mmHg)
• Very significant hemodilution (3-15 times greater)
• Pump flows range from 200ml/kg/min to zero!
• Different blood pH management (alpha-stat vs pH stat)
• Tendency to hypoglycemia
• Cannula placement is much more critical
![Page 52: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/52.jpg)
Anticoagulation and haemostasis during CPB
Anticoagulation
Heparin
• time of administration
• Route – central line
![Page 53: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/53.jpg)
Current clinical protocol • Heparin – 300 units/kg i.v.• Draw arterial sample for ACT in 3-5 min.• Give additional heparin to achieve
ACT >300 (normothermic CPB)
ACT > 400 (hypothermic CPB)• Prime extracorporial circuit with heparin 3 units/ml•
![Page 54: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/54.jpg)
• Monitor ACT every 30 min. during CPB
• If ACT decreases below desired minimum value – supplemental dose of 50-100 units/kg
![Page 55: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/55.jpg)
Haemostasis
At conclusion of CPB
• Protamine – mainstay of heparin neutralization
• Dosage – 1.3 mg to neutralise 100units of heparin
• ACT after administration
if more then baseline – additional bolus (25 -50mg)
of protamine
![Page 56: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/56.jpg)
protamine reaction
• Increase in PAP & CVP
• Decrease in LAP & SAP
Precaution
• via peripheral line
• Administer slowly < 5mg/min.
• Test bolus dose 25-50 mg – look for haemodynamics
• Careful with pt. having food allergy
![Page 57: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/57.jpg)
Treatment
• Stop protamine
• Administration of fluids and epinephrine
• Steroids
• Pulmonary vasodialators - NTG, SNP
![Page 58: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/58.jpg)
Congenital Cardiac Surgery
• Deep hypothermic circulatory arrest (DHCA)– Neonates and small infant usually < 10 kg– Oxygen consumption falls 2-2.5 times per 10
degree fall in temperature– Allows more controlled complex surgery in a
bloodless field– Often total CPB time is actually shortened by this
technique
![Page 59: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/59.jpg)
Congenital Cardiac Surgery
• Weaning from CPB– Heart assessed by direct visualization and right or
left atrial filling pressure, central cannula or TEE– Pulse oximetry is also very helpful– Problems weaning are due to:
• Inadequate repair, • pulmonary hypertension • And/or left or right ventricular dysfunction
![Page 60: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/60.jpg)
Congenital Cardiac Surgery
• Weaning from CPB– Problems weaning diagnosed by
• Intraoperative cardiac catheterization
• Echo-doppler
– Leaving the operating room before correcting the problem leads to a significant INCREASE in morbidity
![Page 61: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/61.jpg)
Postoperative care
• Observation on a monitored bed in ICU/HDU for 24 hours or overnight atleast because of their predisposition to develop ventricular/ supraventricular tachycardia, bradyarrhythmia and myocardial ischemia
• Meticulous attention to fluid balance to prevent hypovolumia• Monitoring of blood pressure preferably invasive, Oxygen saturation and
CVP• Position slowly- risk of postoperative postural hypotension with secondary
increase in right to left shunting • Prevention of venous stasis by early ambulation and by applying effective
elastic stocking or periodic pneumatic compression.• Adequate pain management – adverse hemodynamics and possibly
hypercoagulable state
![Page 62: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/62.jpg)
Post op pain management
• Opioid analgesia
• Regional analgesia
• Alternative and supplementary analgesia
![Page 63: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/63.jpg)
Congenital Cardiac Surgery
• Selected Specific Conditions/Procedures:– Tetralogy of Fallot– Patent Ductus Arteriosus(PDA)– ASD– VSD
![Page 64: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/64.jpg)
TETRALOGY OF FALLOT
![Page 65: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/65.jpg)
TETRALOGY OF FALLOT
• 10% of all CHD
• Most common R – L shunt
• 4 anomalies:– RVOT obstruction ( infundibular, pulmonic or
supravalvular stenosis )– Subaortic VSD– Overriding aorta– RVH
![Page 66: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/66.jpg)
CXR IN TOF
• Normal heart size
• Pulmonary oligemia
• Upturned cardiac apex
• Rt aortic arch
![Page 67: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/67.jpg)
TOF : Coagulation Abnormalities
• Thrombocytopenia
• Platelet functional defects
• Hypofibrinogenemia
• Elevated PT, APTT.
![Page 68: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/68.jpg)
Congenital Cardiac Surgery
• Laboratory data– Cyanosis leads to polycythemia
• May consider phlebotomy esp if no CPB
• Leads to coagulation problems
– Anemia may be “relative” and need transfusion– Newborn infant has immature systems including
renal/hepatic/coagulation– Hypoglycemia is much more common
![Page 69: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/69.jpg)
Airway Abnormalities in TOF
• TOF with pulmonary atresia: tracheomalacia, bronchomalacia
• Associated syndromes – DiGeorge syndrome, CHARGE, Goldenhar’s syndrome, Down’s syndrome.
![Page 70: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/70.jpg)
TETRALOGY OF FALLOT
• Hypercyanotic ( “tet” ) spells occur D/T infundibular spasm, low pH or low PaO2
• In awake patient manifests as acute cyanosis & hyperventilation
• May occur with feeding, crying, defecation or stress
• During anesthesia D/T acute dynamic infundibular spasm
![Page 71: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/71.jpg)
Triggers
• ↑O2 demand
• crying feeding defecation
• Hypovolemia
• Relative anemia
• Anxiety
• Hypoxia hypercarbia acidosis
![Page 72: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/72.jpg)
TETRALOGY OF FALLOT
• Treatment of Hypercyanotic Spells– High FiO2 → pulmonary vasodilator → ↓ PVR– Hydration (fluid bolus) → opens RVOT– Morphine (0.1mg/kg/dose) → sedation,↓ PVR– Ketamine → ↑ SVR, sedation, analgesia → ↑ PBF– Phenylephrine (1mcg/kg/dose) → ↑ SVR– β-blockers (Esmolol 100-200mcg/kg/min)
→ ↓HR,-ve inotropy → improves flow across obstructed valve &↓ infundibular spasm
![Page 73: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/73.jpg)
Volatile Esmolol Propranolol ↑ depth of ↓ HR & anesthesia contractility
↑ pre load ↓ infundibular spasm
↓ acidosis TREATMENT (NaHCO3)
↑SVR ↓ PVR
Phenylnephrine norepinephrine posture1-10µg/kg 0.01µg/kg
![Page 74: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/74.jpg)
Congenital Cardiac Surgery
• Tetralogy of Fallot– Preoperative Preparation
• Heavy premedication
– Consider IM ketamine or inhalation induction but get rapid control of airway.
– Keep SVR up and PVR down, maintain heart rate– Intraoperative TEE
![Page 75: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/75.jpg)
Congenital Cardiac Surgery
• Tetralogy of Fallot– Weaning from CPB, ratio RV:LV pressure should
be < 0.8– May need to keep PVR low with NTG, milrinone,
dobutamine phentolamine, PGE1
– May need RV inotrope post op– May need temporary pacing wire
![Page 76: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/76.jpg)
Congenital Cardiac Surgery
• Tetralogy of Fallot– Perioperative concerns
• Increase in PVR or decrease in SVR leading to Right to Left shunt
• Tet Spells pre induction (crying/anxiety)
• Polycythemia and bleeding
• Air embolus
• RV failure
![Page 77: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/77.jpg)
PALLIATIVE SHUNTS IN TOF
• Blalock-Taussig shunt [anastomosis of
subclavian artery and pulmonary artery]
• Modified B-T shunt [Goretex graft used]
• Pott’s shunt [descending aorta left pulmonary
artery]
• Waterston’s shunt [ascending aorta right
pulmonary artery]
![Page 78: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/78.jpg)
Patent Ductus Arteriosus
• Ductus Arteriosus connects the descending aorta to the main pulmonary trunk near the origin of the left subclavian
• Normal postnatal closure results in fibrosis- which becomes the ligamentum arteriosum.
• Small PDA does not increase risk for heart failure- but does carry a risk for bacterial endocarditis.
![Page 79: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/79.jpg)
Congenital Cardiac Surgery
• PATENT DUCTUS ARTERIOSUS– 1/8000 live births, associated with prematurity
and female predominance of approx 3:1– Left to right shunt causes pulmonary edema– Occasionally right to left cause lower body
cyanosis– SpO2 probe on Right hand and lower limb
• Confirms correct vessel ligated
– Vagal reflex is pronounced by lung traction– Antibiotics required to prevent endocarditis
![Page 80: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/80.jpg)
• Confirmation of crossmatched blood in OT.
• Radial arterial line preferably on opposite side of aortic arch.
• At the time of PDA ligation SBP reduced to 80-90 mm of hg with Halothane/SNP
• Watch for haemorrhage due to rupture.
![Page 81: Anaesthesia for congenital heart disease](https://reader030.vdocuments.us/reader030/viewer/2022020717/5463159bb4af9f6c1c8b4964/html5/thumbnails/81.jpg)
Thank you!!