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AN ANTIGENIC MAP OF CEREBELLAR TOPOGRAPHY

RICHARD HAWKES

DEPARTMENT OF BIOCHEMISTRY AND LABORATORY OF NEUROBIOLOGY,

LAVAL UNIVERSITY, QUEBEC, P.Q., GIK 7P4, CANADA.

Keys words: cerebellum - monoclona] antibodies - pattern formation

Functional maps of the cerebellar cortex reveal a complex somatotopy.

The anatomical substrate for functional parcellation is the precisely ordered

pattern of afferent and efferent projections. We have supposed that the

anatomical and physiological differences are also reflected at the molecular

level and have raised monoclonal antibodies to eerebellar polypeptides so

as to identify molecular correlates of regional differentiation. This

presentation will discuss:

i) antigens which reflect cerebellar topography

ii) the 3D map of eerebellar parcellation

iii) the correlation between the antigenic map and afferent/efferent

connectivity

iv) functional/somatotopic correlates of the antigenic map

v) the development and plasticity of cerebellar topography

This work was supported by grants from the Medical Research Council of

Canada.