amphetamines
DESCRIPTION
Amphetamines. Matthew Giannetti. Amphetamine Names. Street Name: Co-pilots Speed Crank Dex Brand Name: Adderall Vyvanse Dexadrine Benzedrine in the past Chemical Name: alpha- methylphenethylamine. Drug Action. Amphetamines modulate the neurotransmitters in the brain: dopamine - PowerPoint PPT PresentationTRANSCRIPT
AmphetaminesMatthew Giannetti
Amphetamine NamesStreet Name:
Co-pilotsSpeedCrankDex
Brand Name:AdderallVyvanseDexadrineBenzedrine in the past
Chemical Name:alpha-methylphenethylamine
Drug ActionAmphetamines modulate the neurotransmitters in the brain:
dopamineserotoninnorepinephrine
Action happens in the nucleus accumbens, striatum, and prefrontal cortex.
areas of the brain implicated in reward
However, the action only takes place in specific places.
Ex. Dompamine receptors in the hippocampus
Low Dose High DoseDrug Action
History & Medical UseJanuary 18, 1887
Amphetamine is first synthesized at Universitat Berlin by Romanian chemist Lazar Edeleanu.
1930’s Amphetamine approved by AMA for sale in tablet form to treat narcolepsy and ADHD.
40’s & 50’sAmphetamine is distributed to troops in WWII and The Korean War
History & Medical Use cont.
October 27, 1970Injectable methamphetamine is named a Schedule II drug. Other amphetamines & non-injectable methamphetamine are named Schedule III drugs.
July 7, 1971Amphetamines and non-injectable methamphetamine are moved from Scdule III to Schedule II drugs.
1996U.S. Congress passes act establishing new controls over key ingredients and strengthening criminal penalties for possession, distribution, and manufacturing
Amphetamine Derivatives
Physiological Effects of Amphetamines
Clench/Grind teethRapid breathingVasoconstrictionHyper and hypotensionHyperactivity and insomniaDiarrhea and/or constipationTachycardia and BradycardiaSiezure, stroke, coma, heart attack, and death
Psychological Effects of Amphetamines
Euphoria SociabilitySelf-esteem Anxiety and paranoiaIrritability and agressionAlterness and concentrationRepetitive and obsessive behaviors
Possible Side EffectsDepressionAnxiety Increased appetiteAgitationVivid or lucid dreamsSuicidal ideation
Bibliography"Erowid Amphetamine (Adderall) Vault." Erowid. 13 Jan. 2012. Web. 29 Feb. 2012. <http://www.erowid.org/chemicals/amphetamines/>."Methamphetamine." Home. Web. 29 Feb. 2012. <http://www.drugabuse.gov/drugs-abuse/methamphetamine>."Autonomic Pharmacology." Medical Pharmacology: Table_of_Contents. Web. 29 Feb. 2012. <http://www.cybermedicine2000.com/pharmacology2000/Autonomics/Adrenergics1/Adrenergic-32.htm>."Amphetamines | CESAR." CESAR (Center for Substance Abuse Research). Web. 29 Feb. 2012. <http://www.cesar.umd.edu/cesar/drugs/amphetamines.asp>."Important Facts About Amphetamine Abuse." Important Facts About Amphetamines: Main Line Health, Philadelphia, Pennsylvania. Web. 29 Feb. 2012. <http://www.mainlinehealth.org/stw/Page.asp?PageID=STW000195>.