wang chung han. asd impaired brain development behavioral cognitive physical abnormalities social...
Post on 13-Dec-2015
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ASDimpaired brain development BehavioralCognitivephysical abnormalitiessocial interaction
Gut distressdysbiosis of the microbiotainflammatory bowel diseaseObesitycardiovascular disease
INTRODUCTION
Mice and humansocial Emotionalanxiety-like behaviorsbrain development and function
EXPERIMENTAL PROCEDURES(maternal immune activation;MIA)Mice
i.p. on E12.5 with saline or 20 mg/kg poly(I:C)
OffspringBacteroides fragilis
every other day for 6 days at weaning
Intestinal Permeability4 kDa FITC-dextran
Behavioral Testing
MIA Offspring Exhibit GI BarrierDefects
DSS:Dextran sulfate sodium S:saline+vehicleP:poly(I:C)+vehicle
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