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VOLUME 48 CONTENTS
No 1 JANUARY 1993 Page Editorials1 Chlamydia pneumoniae TJ3Marrie5 Cohabiting with domestic mites IH Feather, JA Warner, S THolgate, PJ_ Thompson, GA Stewart
Original articles10 Concentrations of the domestic house dust mite allergen Der p I after treatment with solidified benzyl benzoate
(Acarosan) or liquid nitrogen S Kaira, P Crank, J Hepworth, CA C Pickering, A A Woodcock14 Relation of passive smoking as assessed by salivary cotinine concentration and questionnaire to spirometric indices
in children D G Cook, PH Whincup, 0 Papacosta, D P Strachan, MJJ3'arvis, A Bryant21 Lung function, respiratory illness, and passive smoking in British primary school children R J Rona, S Chinn26 Activated memory T helper cells in bronchoalveolar lavage fluid from patients with atopic asthma: relation to
asthma symptoms, lung function, and bronchial responsiveness D S Robinson, A M Bentley, A Hartnell, A B Kay,S R Durham
33 Effect of arterial oxygen desaturation on six minute walk distance, perceived effort, and perceived breathlessness inpatients with airflow limitation VH FMak, J R Bugler, CM Roberts, S G Spiro
39 Airspace size in lungs of lifelong non-smokers: effect of age and sexM Gillooly, D Lamb44 Asthma related hospital treatment in Finland: 1972-86 TKeistinen, T Tuuponen, S-L Kivela48 Quantitative versus qualitative analysis of peak expiratory flow in occupational asthma J Cte, S Kennedy,
M Chan-Yeung52 Pulmonary endocrine cells ofAymara Indians from the Bolivian Andes D Williams, D Heath, J Gosney,
J Rios-Dalenz57 Segregation of eosinophil proteins in alveolar macrophage compartments in chronic eosinophilic pneumonia
A Janin, G Torpier, P Courtin, M Capron, L Prin, A-B Tonnel, P-YHatron, B Gosselin63 Effect of bumetanide on toluene diisocyanate induced contractions in guinea pig airways C E Mapp, A Boniotti,
A Papi, CA Maggi, A Di Stefano, M Saetta, A Ciaccia, L M Fabbri68 Aerosolised ribavirin in patients with advanced cryptogenic fibrosing alveolitis: a pilot study C Agusti, A Xaubet,
E Ballester, A Alarc6n, C Picado70 Pulmonary gangrene and the air crescent signJM Reich75 Diagnosis of pulmonary cryptococcosis by ultrasound guided percutaneous aspiration L-N Lee, P-C Yang,
S-H Kuo, K-T Luh, D-B Chang, C-J Yu
Review series79 New perspectives on basic mechanisms in lung disease * 2-Neutrophil traffic in the lungs: role of
haemodynamics, cell adhesion, and deformability WMacNee, C Selby
Technical note89 A nomogram for obtaining the partial pressure of oxygen in alveolar air A Karnik, D R Karnad
Short reports91 Outbreak of Moraxella catarrhalis in a respiratory unit S J7 Richards, A P Greening, M C Enright, M G Morgan,
H McKenzie92 Severe bleomycin lung toxicity: reversal with high dose corticosteroids Jf Maher, PA Daly94 Pseudomyxoma of the pleural and peritoneal cavities G Radosavljevi6, B Nedelikovi6, VKaear
Letters to the editor96 Smoking among children and young people in Japan H Kawane * Controlled trial of respiratory muscle training in
chronic airflow limitation PNR Dekhuijzen, C L A van Herwaarden, H TM Folgering; G Guyatt
Miscellaneous95 Book notice - Notices
No 2 FEBRUARY 1993 Editorials97 New perspectives in Wegener's granulomatosis R B Dreisin100 Nocturnal asthma N J Douglas
Altounyan address103 Mediator and cytokine mechanisms in asthma S Holgate
Original articles110 Physiological effect of endobronchial radiotherapy in patients with major airway occlusion by carcinoma
J M Goldman, A S Bulman, A 7 RathmeUl, B M Carey, M F Muers, C A FJ'oslin115 Diagnostic rigid and flexible oesophagoscopy in carcinoma of the oesophagus: a comparison A J Ritchie,
J' McGuigan, K McManus, HM Stevenson, J R P Gibbons119 Influence of smoking habits on change in carbon monoxide transfer factor over 10 years in middle aged men
A Watson, HJ7oyce, L Hopper, N B Pride125 Arousal responses to added inspiratory resistance during REM and non-REM sleep in normal subjectsM Gugger,
S Bogershausen, L Schaffler130 Effect of an oral potassium channel activator, BRL 38227, on airway function and responsiveness in asthmatic
patients: comparison with oral salbutamol J C Kidney, R WFuller, YM Worsdell, EA Lavender, KF Chung,PJ Barnes
134 Regular inhaled ,B agonist in asthma: effects on exacerbations and lung function D R Taylor, M R Sears,G P Herbison, EM Flannery, C G Print, D C Lake, D M Yates, M K Lucas, Q Li
139 Total population survey of the frequency and severity of asthma in 17 year old boys in an urban area in IsraelI Auerbach, C Springer, S Godfrey
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142 Relation of the hypertonic saline responsiveness of the airways to exercise induced asthma symptom severity and tohistamine or methacholine reactivityHK Makker, S T Holgate
148 Twelve month comparison of salmeterol and salbutamol as dry powder formulations in asthmatic patientsB Lundback, D WRawlinson, J B D Palmer on behalf ofa European study group
154 Pulmonary deposition of a nebulised aerosol during mechanical ventilation S H L Thomas, MJ O'Doherty,HM Fidler, CJ Page, D F Treacher, TO Nunan
160 Rapid detection ofpneumococcal antigen in pleural fluid of patients with community acquired pneumoniaWG Boersma, A Lfwenberg, Y Holloway, H Kuttschrutter, J A M Snijder, GH Koeter
163 Peak expiratory flow in rural residents of Tamil Nadu, India D Ray, A Rajaratnam, J Richard167 Ultrasound guided aspiration biopsy for pulmonary tuberculosis with unusual radiographic appearances A Yuan,
P-C Yang, D-B Chang, C-J Yu, L-N Lee, H-D Wu, S-H Kuo, K-TLuh171 Pulmonary alveolar microlithiasis: review of Turlish reports E S Ucan, A I Keyf, R Aydilek, Z Yalcin, S Sebit,
M Kudu, U Ok174 Attitudes to smoling and smoking habits among hospital staffS F Hussain, S Tjeder-Burton, IA Campbell,
PD 0 DaviesReview series
176 New perspectives on basic mechanisms in lung disease-3: Drug intervention in asthma: present and futureVA Alabaster, B A Moore
Short reports183 Bronchial rupture secondary to blunt chest trauma C Hartey, GN Momitt185 Primary malignant melanoma of the oesophagus with a left atrial metastasis M Chello, A R Marchese, A Panza,
P Mastroroberto, F Di Lello187 Diverticulosis of the main bronchi: a rare cause of recurrent bronchopneumonia in a child A Barbato, A Novello Jr,
D Zanolin, P Corner, E Talenti189 Broncho-oesophageal fistula treated effectively without surgical resection G WParry, A Juma, J E Dussek
Letters to the editor191 Pulmonary complications ofHIV disease S Crowley, GA Luzzi, VKitchen, E Claydon; R Miller, D Mitchell - Acute
pneumonitis associated with low dose methotrexate treatment for rheumatoid arthritis W Hassan, M Carpenter,C Kelly * Tuberculosis contact tracing: are the British Thoracic Society guidelines stil appropriate? A Bush
Miscellaneous192 Book notices - Notices * Correction
No 3 MARCH 1993 Editorials193 Tuberculosis and HIV: blind man's buffP D 0 Davies195 Diuretics and asthma PJ Barnes197 Asthma guidelines: who is guiding whom and where to?M G Pearson
Original articles199 Tuberculosis and HIV: estimates of the overlap in England and Wales JM Watson, S K Meredith,
E Whitmore-Overton, B Bannister, J H Darbyshire204 Changing patterns of respiratory disease in HIV positive patients in a referral centre in the United Kingdom
between 1986-7 and 1990-1 A D Pitkin, A D Grant, NM Foley, R F Miller208 The effect of inhaled frusemide on airway sensitivity to inhaled 4-5% sodium chloride aerosol in asthmatic subjects
L TRodwell, S D Anderson, JI du Toit, J P Seale214 Respiratory symptoms questionnaire for asthma epidemiology: validity and reproducibilityKM Venables, N Farrer,
L Sharp, B J Graneek, A J Newman Taylor220 Lung deposition of nebulised pentamidine in children MJ' O'Doherty, SHL Thomas, D Gibb, CJI Page,
C Harnngton, C Duggan, T0 Nunan, N TBateman227 Value of theophylline treatment in patients handicapped by chronic obstructive lung disease S E McKay,
CA Howie, A H Thomson, B Whiting, GJ Addis233 Large volume spacer devices and the influence of high dose beclomethasone dipropionate on hypothalamo-
pituitary-adrenal axis function PH Brown, A P Greening, G K Crompton239 Measurement of airway responsiveness to methacholine: relative importance of the precision of drug delivery and
the method of assessing response J R Beach, C L Young, A _J Avery, S C Stenton, JH Dennis, E H Walters,D J Hendrick
244 Association of severe asthma attacks with weather, pollen, and air pollutants 0 VJ Rossi, VL Kinnula, J Tienari,E Huhti
249 Relation between response to exercise and diumal variability of peak expiratory flow in primary school childrenTh Frischer, J Kuhr, R Meinert, WKarmaus, J Forster, R Urbanek
254 Forced oscillation technique and spirometry in cold air provocation tests G J Wesseling,IM L Vanderhoven-Augustin, E FM Wouters
260 Failure of frusemide to increase production of prostaglandin E2 in human nasal mucosa in vivo J Mullol, I Ramis,J' Prat, J Rosel-Catafau, A Xaubet, C PIera, E Gelpi, C Picado
264 Additive effects of exposure to silica dust and smoking on pulmonary epithelial permeability: a radioaerosol studywith technetium-99m labelled DTPA L E Nery, R T Florencio, PR M Sandoval, R T Rodrigues, G Alonso,G R Mason
269 Malignant mesothelioma in women A Dawson, A R Gibbs, FD Pooley, DM Griffiths, J Hoy275 Model for investigating snorers with suspected sleep apnoea H Rauscher, W Popp, H Zwick280 Evaluation of a computerised polysomnography system H Biernacka, NJ Douglas284 Deaths and necropsies in a thoracic unit D A R Boldy, C Jones, H Matthews, C Edwards287 Effect of oral bronchodilators on lung mucociliary clearance during sleep in patients with asthma A Hasani,J E Agnew, D Pavia, H Vora, S W Clarke
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Review series290 New perspectives on basic mechanisms in lung disease: 4-Why are the airways so vascular? J Widdicombe
Conference report296 Second Intemational Conference on Advances in Pulmonary Rehabilitation and Management of Chronic
Respiratory Failure, Venice, 4-7 November 1992MD L Morgan
Short reports298 Intrathoracic vagus nerve neurofibroma and sudden death in a patient with neurofibromatosis L T-C Chow,
B S-F Shum, W-H Chow300 Inhalation trauma due to overheating in a microwave oven A L Zanen, A P Rietveld
Letters to the editor303 Management of puhmonary embolismN WMorrell, WA Seed; J'M Shapiro, J7A Albino; HH Gray, S Firoozan a
National survey of notifications of tuberculosis in England and Wales in 1988 PD 0 Davies; S Meredith * Does apositive Heaf test reaction in Asian schoolchildren predict later breakdown of tuberculosis? PD 0 Davies;J7 B Cookson, A G I Cookson * Tuberculosis contact tracing: are the British Thoracic Society guidelines stillappropriate? PD 0 Davies
Miscellaneous302 Book notices
No 4 APRIL 1993 Editorials305 Inhaled corticosteroids in COPD: awaiting controlled trials JA Wedzicha308 Bronchodilators in infancy JfB Clough
Original articles309 Effects of high dose inhaled beclomethasone dipropionate, 750 ug and 1500 pg twice daily, and 40mg per day oral
prednisolone on lung function, symptoms, and bronchial hyperresponsiveness in patients with non-asthmatic chronicairflow obstruction D C Weir, PS Burge
317 Effect of salbutamol on histamine induced bronchoconstriction in healthy infants A J WHenderson, S Young,SM Stick, L I Landau, PN LeSouef
324 Comparative nasal effects of bradykinin and histamine; influence on nasal airways resistance and plasma proteinexudation K Rajakulasingam, R Polosa, L C K Lau, MK Church, S T Holgate, PH Howarth
330 Double blind trial of ionisers in children with asthma sensitive to the house dust mite J A Warner, JfL Marchant,JO Warner
334 Accuracy of the typical computed tomographic appearances of fibrosing alveolitis K T Tung, A U Wells,MB Rubens, JfM E Kirk, R M du Bois, DM Hansell
339 Palliation of symptoms in non-small cell lung cancer: a study by the Yorkshire Regional Cancer Organisationthoracic groupMF Muers, CE Round on behalfof the group
344 Synchronous primary lung cancers: prevalence in surgical material and clinical implications FA Carey,S C Donnelly, WS Walker, E WJ Cameron, D Lamb
347 Diagnosis of asbestosis by a time expanded wave form analysis, auscultation and high resolution computedtomography: a comparative study NAl jarad, B Strickland, G Bothamley, S Lock, R Logan-Sindair, R M Rudd
354 Measurement of inspiratory muscle performance with incremental threshold loading: a comparison of twotechniques PA Bardsley, S Bendey, H S Hall, SJI Singh, D H Evans, MDL Morgan
360 Surgical correction of nasal obstruction in the treatment of mild sleep apnoea: importance of cephalometry inpredicting outcome F Series, S St Pierre, G Carrier
364 Interference with the oxidative response of neutrophils by Streptococcus pneumoniae F E Perry, CJ Elson,L W Greenham, J R Catterall
370 A study of Spanish sepiolite workers KMcConnochie, C Bevan, R G Newcombe, J P Lyons, J W Skidmore,Y C Wagner
375 Body weight and weight gain related to pulmonary function decline in adults: a six year follow up study Y Chen,S L Home, Y A Dosman
381 Static lung volumes in healthy subjects assessed by helium dilution during occlusion of one mainstem bronchusBJohansen, 0 Biortuft, J Boe
385 Glycerol particle cigarettes: a less harmful option for chronic smokers G Sutherland, MA H Russell, YA Stapleton,C Feyerabend
388 Histological examination of peroperative frozen sections in suspected lung cancer S A M Nashef, Y G Kakadellis,PS Hasleton, Y S Whittaker, CM Gregory, M TYonesReview series
390 New perspectives on basic mechanisms in lung disease: 5-Respirable industrial fibres: mechanisms ofpathogenicity K Donaldson, R C Brown, GM Brown
Occasional review396 A role for capsaicin sensitive, tachykinin containing nerves in chronic coughing and sneezing but not in asthma: a
hypothesis J-A Karlsson
Short reports401 Treatment of resistant pain in hypertrophic pulmonary arthropathy with ketorolac N Blackwell, L Bangham,
M Hughes, D Melzack, I Trotman402 Miliary pulmonary cryptococcosis in a patient with the acquired immunodeficiency syndrome J D Douketis,
S Kesten404 Combined oesophageal adenocarcinoma and carcinoid in Barrett's oesophagitis: potential role of
enterochromaffin-like cells in oesophageal malignancy N R B Cary, D J Barron, J P McGoldrick, F C Wells405 Suture granuloma simulating lung neoplasm occurring after segmentectomy G Fink, P Herskovitz, M Nili,
H Hadar, A Rothem, SA Spitzer407 Malignant mesenchymoma of the chest wall in an adult S KJYain, M Afzal, M Mathew, S K Ramani
409 Liposarcomatous differentiation in diffuse pleural mesothelioma Y Krishna, M T Haqqani
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Letters to the editor411 Allergic alveolitis due to goose feathers in a duvetA Seaton * Effect of dietary sodium on the severity of bronchial
asthma T C Beard * Notification of tuberculosis: how many cases are never reported?JM Grange * Attenuation ofexercise induced asthma by local hyperthermiaMM Nieminen
Miscellaneous411 Book notices - Notices
Proceedings413 British Thoracic Society winter meeting 1992
No 5 MAY 1993 Editorials469 Photodynamic therapy of lung cancer S Lam470 Do bronchodilators adversely affect the prognosis of bronchial hyperresponsiveness? C P van Schayck,
C LA van Herwaarden
Original articles474 Experimental studies to assess the potential of photodynamic therapy for the treatment of bronchial carcinomas
S G T Smith, J Bedwell, A J MacRobert, MH Griffiths, S G Bown,MR Hetzel481 Reduced carbon monoxide transfer factor (TLco) in human immunodeficiency virus type I (HIV-1) infection as a
predictor for faster progression to AIDS R B Nieman, J Fleming, RJ Coker, J R William Harris, DM Mitchell486 Skeletal muscle metabolism during exercise and recovery in patients with respiratory failure CH Thompson,
RJ 0 Davies, G7 Kemp, DJI Taylor, GK Radda, B Rajagopalan491 Microscopic emphysema in relation to age and smoking habitM Gillooly, D Lamb496 Discriminant analysis of symptom pattern and serum antibody titres in humidifer related disease C McSharry,
KAnderson, A Speekenbrink, C Lewis, G Boyd501 Psychiatric and social aspects of brittle asthma GMF Garden, J G Ayres506 Lung deposition patterns of directly labelled salbutamol in normal subjects and in patients with reversible airflow
obstruction R Melchor, MF Biddiscombe, VHF Mak, MD Short, S G Spiro512 Variability of the plateau response to methacholine in subjects without respiratory symptomsMD Lougheed,
G Pearce-Pinto, NH Ilerk, G Ryan, A WMusk, A James518 Evaluation of albumin as a reference marker of dilution in bronchoalveolar lavage fluid from asthmatic and control
subjects C Ward, M Duddridge, J Fenwick, P V Gardiner, A Fleetwood, D Jf Hendrick, EH Walters523 Haemodynamic effects of pressure support and PEEP ventilation by nasal route in patients with stable chronic
obstructive pulmonary disease N Ambrosino, S Nava, A Torbicki, G Riccardi, C Fracchia, C Opasich, C Rampulla529 Nasal CPAP and weight loss in hypertensive patients with obstructive sleep apnoea H Rauscher, D Formanek,
W Popp, H Zwick534 Sleep related hypoxaemia in hypertensive and normotensive men I C Gleadhill, E E McCrum, C C Patterson,
G D Johnston, A Evans, J MacMahon537 Effects of posture on carbon dioxide responsiveness in patients with obstructive sleep apnoeaM Satoh, WHida,
T Chonan, S Okabe, H Miki, 0 Taguchi, Y Kikuchi, T Takishima542 Effect of azelastine on sulphur dioxide induced impairment of ciliary motility in airway epitheliumJ
_ Tamaoki,A Chiyotani, N Sakai, K Takeyama, K Konno
547 Salmeterol, formoterol and salbutamol in the isolated guinea pig trachea: differences in maximum relaxant effectand potency but not in functional antagonism A Linden, A Bergendal, A Ulman, B-E Skoogh, C-G Lofdahl
554 Sensory neuropeptides and hypoxic pulmonary vasoconstriction in the rat D G McCormack, R G Rees, D Crawley,PJ Barnes, T WEvans
558 Central venous catheter associated thrombosis of major veins: thrombolytic treatment with recombinant tissueplasminogen activator S Rodenhuis, L G FM van't Hek, L T Vlasveld, R Kroger, R Dubbelman, R G L van Tol
Review series560 New perspectives on basic mechanisms in lung disease 6-Proteinase imbalance: its role in lung disease
TD Tedey
Short reports566 Effect of preservative on the efficacy of terbutaline nebuliser solution in atopic asthma C K W Lai, C H S Chan568 Mediastinal mass caused by syphilitic aortitis R Hofmann-Wellenhof, WDomej, C Schmid, D Rossmann-Moore,
P KuUnig, M Annelli-Monti570 Association of cadmium exposure with rapidly progressive emphysema in a smoker D Leduc, P de Francquen,
DJ7acobovitz, R Vandeweyer, R Lauwerys, P De Vuyst572 Multiple recurrent intrapulmonary and endobronchial mesenchymomas (hamartomas) CM Laroche, S Stewart,
F WeUs, J Shneerson574 Prolonged hypoxaemia after nebulised salbutamol G Connett, WLenney576 Reversal of hypoxia in a patient with chronic obstructive pulmonary disease, pulmonary hypertension and oedema
during treatment with long term domiciliary oxygen KM Skwarski, D Morrison, WMacNee578 Pneumatoceles and pneumothoraces complicating staphylococcal pneumonia: treatment by synchronous
independent lung ventilation A W Lohse, 0 Klein, E Hermann, H Ldhr, KF Kreitner, H Steppling,K-H Meyer zum Buschenfelde, M Staritz
580 Pulmonary and cutaneous vasculitis following hepatitis B vaccination MB Allen, P CockweUl, R L Page
Letters to the editor582 Effect of aminophylline on brain tissue oxygenation in patients with chronic obstructive lung disease G J Addis;
M Nishimura * Concentrations of the domestic house dust mite allergen Der p I after treatment with solidifiedbenzyl benzoate (Acarosan) or liquid nitrogen TK Ninan, G Russell, M Omran; A A Woodcock, S Kalra *Notification of tuberculosis: how many cases are never reported? L P Ornerod;N C Barnes, C D Sheldon -
Diagnosis of Pneumocystis carinii pneumonia in HIV antibody positive patients by simple outpatient assessmentsR B Nieman, RJ Coker, D M Mitchell; B G Gazzard, D E Smith *Pathological assessment of mediastinal lymphnodes in lung cancer: implications for non-invasive mediastinal staging S-H Ren, S-J Xu;KM Kerr, NJ Douglas.Guidelines for care during bronchoscopy B D WHarrisonMiscellaneous
584 Notices
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No 6 JUNE 1993 Editordals585 Osteoporosis and cystic fibrosis T C B Stamp, D M Geddes587 Role of thoracic radiotherapy in small cell lung cancer J S Tobias
Original articles589 Bone mineral density and body composition in adult patients with cystic fibrosis A B Grey, R WAmes,
R D Matthews, I R Reid594 Effect of a platelet activating factor antagonist, WEB 2086, on allergen induced asthmatic responses
A Freitag, R M Watson, G Matsos, C Eastwood, PM O'Byrne599 Effects of high doses of inhaled corticosteroids on adrenal function in children with severe persistent asthma
TKNinan, I WReid, PE Carter, PJ Smail, G Russell603 Improvement in sodium cromoglycate delivery from a spacer device by use of an antistatic lining, immediate
inhalation, and avoiding multiple actuations of drug C O'Callaghan, J Lynch, M Cant, C Robertson607 Investigations of an optimal inhaler technique with the use of urinary salbutamol excretion as a measure of
relative bioavailability to the lung M Hindle, D A G Newton, H Chrystyn611 Time course and duration of bronchodilatation with formoterol dry powder in patients with stable asthma
A Wallin, T Sandstrim, L Rosenhall, B Melander615 Effect of inhaled procaterol on cough receptor sensitivity to capsaicin in patients with asthma or chronic
bronchitis and in normal subjectsM Fujimura, S Sakamoto, Y Kamio, T Bando, K Kurashima, T Matsuda619 Serum titres of Pneumocystis carinii antibody in health care workers caring for patients with AIDS TR Leigh,
MI Millett, B Jameson, J V Collins622 Enhanced type III collagen gene expression during bleomycin induced lung fibrosis S Shahzeidi, B Mulier,
B de Crombrugghe, PK3Jeffery, RJ McAnulty, GJ Laurent629 Ciliary beat frequency in transplanted lungs D Veale, PN Glasper, A Gascoigne, J H Dark, G J Gibson,
PA Cornis632 Percutaneous needle biopsy of the mediastinum: review of 94 procedures B Morrissey, HAdams, A R Gibbs,
M D Crane638 Effects of recombinant GM-CSF and IgA opsonisation on neutrophil phagocytosis of latex beads coated
with P6 outer membrane protein from Haemophilus influenzae D Burnett, A Chamba, R A Stockley, TF Murphy,S L Hill
643 Use of a combined oxygen and carbon dioxide transcutaneous electrode in the estimation of gas exchangeduring exerciseMK Sridhar, R Carter, F Moran, S WBanham
648 Effect of seasonal allergic rhinitis on airway mucosal absorption of chromium-51 labelled EDTA L Greiff,P Wollmer, C Svensson, M Andersson, C G A Persson
651 Effects of nicotine on the human nasal mucosa L Greiff, P Wollmer, I Erjefdlt, M Andersson, U Pipkorn,C GA Persson
656 Single dosing comparison of the relative cardiac fi1/f, activity of inhaled fenoterol and salbutamol in normalsubjects DM Newnham, NM Wheeldon, B J Lipworth, D G McDevitt
Review series659 Cytokines: Introduction R M du Bois660 Cytokines: 1-Overview L P Nicod
Short reports668 Age related increase in the intra-alveolar macrophage population of non-smokers WA H Wallace, M GiUooly,
D Lamb670 Mucosa associated lymphoma of the lung PH B Bolton-Maggs, A Colman, G R Dixon, M WMyskow,
_' G Williams, RI Donnelly, C R K Hind672 Culture ofMycobacterium kansasii in the blood of an HIV negative patient D Veale, D Fishwick, J'E S White,
A D Gascoigne, K Gould, PA Corns674 Lung abscess: a neglected cause of life threatening haemoptysis NJ Philpott,MA Woodhead, A G Wilson,
FJI C Millard676 Mitral valve replacement for an annular submitral aneurysm of the left ventricle A G K Gokhale, N Lal, B Ashok,
_Jacob, S Krishnaswami, P S airaj
Letters to the editor678 Cohabiting with domestic mites 0 Linna; I H Feather, _A Warner, S THolgate, PJ Thompson, GA Stewart
Tuberculin positive children L 0 Larsson, B-E Skoogh, A Lind;K Citron * Estimating age, sex and periodspecific constant tar cigarette consumption in the UK PN Lee, J S Fry, B A Forey * Alveolar atypicalhyperplasia in association with primary pulmonary adenocarcinoma: a clinicopathological study of 10 casesR R Miller; FA Carey, D Lamb
Miscellaneous680 Book notices * Notice
No 7 JULY 1993 Editorials681 Primary tracheal tumours H C Grilo683 Respiratory muscle strength after upper abdominal surgery B Celli685 To help patients control asthma the clinician must be a good listener and teacher D Evans
Original articles688 Primary tracheal tumours: a national survey C M Gelder, M R Hetzel693 Effect of aminophylline on respiratory muscle strength after upper abdominal surgery: a double blind study
NM Siafakas, A Stoubou,M Stathopoulou, VHaviaras, N Tzanakis, D Bouros698 Lung volume restriction in patients with chronic respiratory muscle weakness: the role of microatelectasisM
Estenne, PA Gevenois, WKinnear, P Soudon, A Heilporn, A De Troyer702 Recruitiment of some respiratory muscles during three maximal inspiratory manoeuvres S Nava, NAmbrosino,
P Crotti, C Fracchia, C Rampulla
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708 Assessment and follow up of patients prescribed long term oxygen treatment LJ Restrck, EA Paul, GM Braid,P Cullinan, Jf Moore-Gillon, IA Wedzicha
714 Effect of alterations of dietary sodium on the severity of asthma in men OJ Carey, C Locke, J B Cookson719 Is the sleep apnoea/hypopnoea syndrome inherited? NJ Douglas,M Luke, R Mathur722 Variability of bronchodilator response and effects of inhaled corticosteroid treatment in obstructive airways
disease HA M Kers4ens, P L P Brand, PH Quanjer, B A HA van der Bruggen-Bogaarts, G H Koeter, D S Postmaon behalf of the Dutch CNSLD Study Group
730 Atrial natriuretic peptide in stable and decompensated chronic obstructive pulmonary disease K Skwarski, M Lee,L Tumbull, WMacNee
736 Fibroblast chemotactic response elicited by native bronchoalveolar lavage fluid from patients with fibrosingalveolitis J Behr, B C Adelmann-Grill, F Krombach, T Beinert, M Schwaiblmair, G Fruhmann
743 Arachnoid nodules in the lungs of high altitude Indians D Heath, D Williams746 Association of silicosis, lung dysfunction, and emphysema in gold miners R L Cowie,M Hay, R G Thomas
Technical note
750 Normal range for transdiaphragmatic pressures during sniffs with catheter mounted transducers S A Evans,L Watson, A J Cowley, I D A Johnston, WJM KinnearOccasional review
754 Obstructive sleep apnoea S G McNamara, R R Grunstein, C E Sullivan
Review series765 Cytokines: 2-Cytokines and lung inflammation: mechanisms of neutrophil recruitment to the lung R M Strieter,
N WLukacs, TJ Standiford, S L Kunkel
Short reports770 Ciliary disorientation: a possible variant of primary ciliary dyskinesia A Rutman, P Cullinan, M Woodhead, PJ Cole,
R Wilson
772 Oesophageal tuberculosis mimicking a tumour during treatment for nodal tuberculosis U Kaur, S Katarnya,S R Bhusnurmath, P Bambery, J B Dilawari
774 Asthma following occupational exposure to Lycopodium clavatum in condom manufacturers P Cullinan, J Cannon,D Sheril, A Newman TaylorLetters to the editor
776 Sex differences in hypokalaemic and electrocardiographic effects of inhaled terbutaline D R Taylor, G P Herbison,MR Sears; B J Lipworth - Inhalation trauma due to overheating in a microwave oven D S C Rose
Miscellaneous776 Notices
No 8 AUGUST 1993 Editorials777 After pneumoniaM Woodhead779 Management of malignant pleural effusion P T Reid, RM Rudd781 Chronic respiratory failure in COPD: is there a place for a respiratory stimulant? PA Bardsley
Original articles785 Factors of importance for the long term prognosis after hospital treated pneumonia J U Hedlund, A B 6rtqvist,
ME Kalin, F Granath
790 Chemical pleurodesis in malignant pleural effusions: a randomised prospective study of mepacrine versusbleomycin S Koldsland, J L Svennevig, G Lehne, EJohnson
794 Lung function in white children aged 4-19 years: I-Spirometry M Rosenthal, S H Bain, D Cramer, P Helms,D Denison, A Bush, J 0 Warner
803 Lung function in white children aged 4-19 years: II-Single breath analysis and plethysmography M Rosenthal,D Cramer, SH Bain, D Denison, A Bush, J 0 Warner
809 Pattern of lung volumes in patients with sighing breathing G Aliadeff, M Molho, I Katz, S Benzaray, Z Yemini,R Jf Shiner
812 Effect of amiloride and saline on nasal mucociliary clearance and potential difference in cystic fibrosis and normalsubjects P G Middleton, D M Geddes, E WF WAlton
817 Comparison of fluticasone propionate with beclomethasone dipropionate in moderate to severe asthma treated forone year L Fabbri, P S Burge, L Croonenborgh, F Warlies, B Weeke, A Ciaccia, C Parker on behalfof an InternationalStudy Group
824 Decrease of histamine induced bronchoconstriction by caffeine in mild asthma J C Henderson, F O'Connell,R WFuller
827 Predicting patient attitudes to asthma medication L M Osman, I T Russell, JA R Friend, J S Legge, J G Douglas831 Tine testing in HIV positive patients S P Higgins, C S Bradbeer, N T Bateman835 Relationship between plasma cell levels and profile of bronchoalveolar lavage fluid in patients with subacute
extrinsic allergic alveolitis M Drent, SjSc Wagenaar, H van Velzen-Blad, P G HMulder, H C Hoogsteden,J MM van den Bosch
840 Phospholipid content of bronchoalveolar lavage fluid in granite workers with silicosis in Quebec R Bigin, 0 Lesur,TBouhadiba, L Guojian, P Larivee,B Melloni, M Martel, A CantinReview series
845 Cytokines: 3-Cytokines in asthma D S Robinson, SR Durham, A B Kay854 Pulmonary rehabilitation in chronic respiratory insufficiency: Introduction J-F Muir, D JTPierson855 Pulmonary rehabilitation in chronic respiratory insufficiency: 1-Pulmonary rehabilitation in perspective: historical
roots, present status, and future projections T L PettyTechnical note
863 Standardisation of gas mixtures for estimating carbon monoxide transfer factor A H Kendrick, G Laszlo
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Short reports866 Tracheal paraganglioma A P Gaflimore, P Goldstraw867 Pleural effusions associated with pancreaticopleural fistula S G J Williams, A Bhupalan, N Zureikat, PJ Thuluvath,
G Santis, N Theodorou, D Westaby869 Upper zone cystic lung disease in HIV related Pneumocystis carinii pneumonia N C Cowan, J Moxham
Letters to the editor871 Regular inhaled ,B agonist in asthma: effects on exacerbations and lung function E EM Van Essen-Zandvliet,
KF Kerrebijn; D R Taylor,M R Sears - Respiratory symptoms questionnaire for asthma epidemiology: validityand reproducibility A M Donoghue * Chlamydia pneumoniae H Kawane
Miscellaneous872 Book notices * Notice
No 9 SEPTEMBER 1993
No 10 OCTOBER 1993
Editorials873 European standards for lung function testing: 1993 update G Laszlo877 flAgonists and ventilation A E Tatersfield, P Wilding879 Effect of air pollution on the prevalence of asthma and allergy: lessons from the German reunification
H Magnussen, R Jorres, D Nowak
Original articles882 Acute effects of inhaled salbutamol on the metabolic rate of normal subjects P Amoroso, S R Wilson, J Moxham,
J Ponte886 Modification of the thermogenic effect of acutely inhaled salbutamol by chronic inhalation in normal subjects
S R Wilson, P Amoroso, J Moxham, I Ponte890 Effect of orally administered beclomethasone dipropionate on calcium absorption from the gut in normal subjects
B J Smith, PJ Phillips, PR Pannafl, HI Cain, WJH Leckie894 Reproducibility of incremental maximal cycle ergometer testing in patients with restrictive lung disease
D D Marciniuk, R E Watts, C G Gallagher899 Factors affecting peak expiratory flow variability and bronchial reactivity in a random population sample
B G Higgins, R Britton, S Chinn, KK Lai, P GI Burney, A E Tattersfield906 Ethnic differences in lung function in Israeli children H Roizin, A Szeinberg, E Tabachnik, M Molho, S Benzaray,
A Augarten, D Har-Even, Z Barzilay, J Yahav911 Daytime sleepiness, cognitive performance and mood after continuous positive airway pressure for the sleep
apnoea/hypopnoea syndrome HM Engleman, KE Cheshire, IJf Deary, NJ Douglas915 Expandable Wallstent for the treatment of obstruction of the superior vena cava A F Watkinson, DM Hansell921 Thoracoscopy assisted pulmonary lobectomy WS Walker, FM Carnochan, M Tin925 Empyema thoracis: a problem with late referral? C W Cham, SM Haq, I Rahamim928 Treatment of symptomatic pulmonary aspergillomas with intracavitary instillation of amphotericin B through an
indwelling catheter MJackson, C D R Flower, JM Shneerson
Review series931 Cytokines: 4-Cytokines and pulmonary fibrosis J Gauldie, MJordana, G Cox936 Pulmonary rehabilitation in chronic respiratory insufficiency: 2-Exercise in patients with chronic obstructive
pulmonary disease M J Belman
Short reports947 Successful treatment of diffuse lipoid pneumonitis with whole lung lavage H-Y Chang, C-W Chen, C-Y Chen,
T-R Hsuie, C-R Chen, W-WLei, M-H Wu, Y-TJin949 Amyloidosis complicating cystic fibrosis K Gaffney, D Gibbons, B Keogh,MX FitzGerald951 Unusual presentation of a large tension bronchogenic cyst in an adult S P Tarpy, H Kornfeld, KMoroz, H L Lazar
953955957
EditorialsTGF-fl antibodies: a novel treatment for pulmonary fibrosis? GJ Laurent, R K Coker, R J McAnultySystemic effects of inhaled corticosteroids J P MonsonDrug resistant tuberculosis: problems on the horizon L P Ornerod
Origal articles959 Effect of antibody to transforming growth factor, on bleomycin induced accumulation of lung collagen in mice
SN Gin, D M Hyde, MA Hollinger967 Systemic effects of high dose inhaled steroids: comparison of beclomethasone dipropionate and budesonide in
healthy subjects PH Brown, S P Matusiewcz, C Shearing, L Tibi, A P Greening, G K Crompton974 Effect of eight months of inhaled beclomethasone dipropionate and budesonide on carbohydrate metabolism in
adults with asthma KKiviranta, M Turpeinen979 Stemomastoid muscle fatigue and twitch maximum relaxation rate in patients with steroid dependent asthma
VHF Mak, Jf R Bugler, S G Spiro985 Correction of glutathione deficiency in the lower respiratory tract of HIV seropositive individuals by glutathione
aerosol treatment KJ Holroyd, R Buhl, Z Borok, J H Roum, A D Bokser, G J Grimes, D Czerski, A M Cantin,R G Crystal
990 Isolation of mycobacteria from patients seropositive for the human immunodeficiency virus (HIV) in south east
England: 1984-92 M D Yates, A Pozniak, YM Grange996 Histologically atypical Pneumocystis carinii pneumonia NM Foley, M H Griffiths, R F Miller
1002 Adult cystic fibrosis: association. of acute pulmonary exacerbations and increasing severity of lung disease withauxotrophic mutants of Pseudomonas aenrginosa R FH Taylor, M E Hodson, T L Pitt
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1006 In vitro bioelectric properties of bronchial epithelium from transplanted lungs in recipients with cystic fibrosisV T Tsang, E WF WAlton, ME Hodson, M Yacoub
1012 Relation between distal airspace size, bronchiolar attachments, and lung function D Lamb, A McLean, M Gilooly,PM Warren, GA Gould, WMacNee
1018 Variability in ciliary beat frequency in normal subjects and in patients with bronchiectasis D Veale, A D Rodgers,CJGriffiths, TAshcroft, GJ Gibson
1021 Lower respiratory tract symptoms in Queensland schoolchildren: risk factors for wheeze, cough and diminishedventilatory function D L Duffy, CA MitchellReview series
1025 Pulmonary rehabilitation in chronic respiratory insufficiency: 3-Ventilatory muscle training R S Goldstein
Occasional review1034 Nitric oxide and lung disease PJ Barnes, M G Belvisi
Short reports1044 Massive haemoptysis caused by congenital absence of a segment of inferior vena cavaM HAshour, S KJain,
KM Kattan, A KEI-Bakry, M Khoshim, FM Mesahel1045 Comparison of nebulised aerosol deposition in the lungs of healthy adults following oral and nasal inhalation
M L Everard, J G Hardy, A D Milner1047 Case of spontaneous haemothorax associated with an endodermal sinus tumourM Karabocuoglu, S Ugur,
N Uzel, E Dayioglu, D Yilmazbayhan, R fihan1048 Catamenial haemoptysis: a rare cause D J Wood, K Krishnan, P Stocks, E Morgan, MJ Ward
Letters to the editor1050 Guidelines on the management of asthma KPJones;M G Pearson, MR Partridge, B D WHarnson
Miscellaneous1050 Book notices * Notices
Proceedings1052 British Thoracic Society summer meeting 1993
No 1 1 NOVEMBER 1993 Editorials1093 Use of near fatal asthma for investigating asthma deaths R Beasley, N Pearce, J Crane1095 Airway hyperresponsiveness: relation to asthma and inflammation? D F Rogers, B J O'Connor1097 Development of bronchus associated lymphoid tissue (BALT) in human lung disease: a normal host defence
mechanism awaiting therapeutic exploitation? P G Holt
Original articles1099 Near fatal asthma attacks: the reliability of descriptive information collected from close acquaintances
D A Campbell, G McLennan, J R Coates, PA Frith, PA Gluyas, KM Latimer, A J Martin, DM Roder,R E Ruffin, D Scarce, PM Yelwlees
1105 Demographic characteristics of patients with severe life threatening asthma: comparison with asthma deathsG N Richards, J Kolbe, J Fenwick, HH Rea
1110 Controlled trial evaluation of an asthma education programme for adults R Yoon, D K McKenzie, A Bauman,D A Miles
1117 A district confidential enquiry into deaths due to asthma NJ Wareham, B D WHarrison, P FJenkins, J NichoUls,D E Stableforth
1121 Changes in methacholine induced bronchoconstriction with the long acting fl2 agonist salmeterol in mild tomoderate asthmatic patients H Booth, K Fishwick, R Harkawat, G Devereux, D J Hendrick, E H Walters
1125 Distribution of immunocompetent cells in the bronchial wall of clinically healthy subjects showing bronchialhyperresponsiveness C Power, S Sreenan, B Hurson, C Burke, L WPoulter
1130 Bronchus associated lymphoid tissue (BALT) in human lung: its distribution in smokers and non-smokersI Richmond, G E Pritchard, TAshcroft, A Avery, PA Corms, EH Walters
1135 How reliable is the diagnosis of lung cancer using small biopsy specimens? Report of a UKCCCR Lung CancerWorling Party J StJ Thomas, D Lamb, TAshcroft, B Comnn, C WEdwards, A R Gibbs, WE Kenyon, RJ Stephens,WF Whimster
1140 Intercellular adhesion molecule 1 (ICAM-1) in the pathogenesis of mononuclear cell alveolitis in pulmonarysarcoidosis K Dalhoff, S Bohnet, J Braun, B Kreft, KJ Wiessmann
1145 Oxygen desaturation and breathlessness during corridor walking in chronic obstructive pulmonary disease: effect ofoxitropium bromide D PS Spence, J G Hay, J Carter, M G Pearson, PMA Calverley
1151 Bronchodilator reversibility to low and high doses of terbutaline and ipratropium bromide in patients with chronicobstructive pulmonary disease D M Newnham, D P Dhillon, J H Winter, CMJackson, R A Clark, B J Lipworth
1156 Bronchoscopic diatherny resection and stent insertion: a cost effective treatment for tracheobronchial obstructionM Petrou, D Kaplan, P Goldstraw
1160 Measurement of exhaled nitric oxide in man C Borland, Y Cox, T Higenbottam1163 Prevalence of chronic cough and phlegm among male cigar and pipe smokers: results of the Scottish Heart Health
Study CA Brown,M Woodward, H Tunstal-Pedoe1168 Time trends and seasonal variation in hospital admissions for childhood asthma in the Athens region of Greece:
1978-88 K Priftis, JAnagnostakis, E Harokopos, I Orfanou,M Petraki, P Saxoni-PapageorgiouReview series
1170 Pulmonary rehabilitation in chronic respiratory insufficiency: 4-Long term domiciliary oxygen therapy in chronicobstructive pulmonary disease MI Walters, PR Edwards, JfC Waterhouse, P Howard
Technical note1178 Thoracoscopic pericardial fenestration: diagnostic and therapeutic aspects A Cana6, R Guijarro, A Arnau,
A Fernaindez-Centeno, MA Ciscar, JfGalbis, A Garcia-Vilanova
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Short reports1181 Mediastinal paraganglioma presenting as an intracardiac mass with superior vena caval obstruction S K Sharma,
S Sharma, S Mukhopadhyay1183 Spontaneous sternal fractures in four patients with chronic airflow obstruction taking corticosteroids K Hameed,
G E Packe, J S Legge, YA R Friend1185 Spontaneous haemothorax: an unusual presentation of primary lung cancer S-H Chou, Y-J Cheng, E-L Kao,
C-Y Chai1186 Need for a comparative performance standard for dry powder inhalers R Richards, M Saunders
Miscellaneous1188 Book notices * Notices * Correction
No 12 DECEMBER 1993 Editorials1189 Leukotrienes and aspirin induced asthma TH Lee, P E Christie1191 HIV in the lung: guilty or not guilty? C Mayaud, J Cadranel1196 Vasodilators in pulmonary hypertension A J Peacock
Altounyan address1200 Out of the mouths ofbabes and sucklings: lessons from early childhood asthmaM Silverman
Original articles1205 Effect of the leukotriene receptor antagonist MK-0679 on baseline pulmonary function in aspirin sensitive
asthmatic subjects B Dahlen, D J Margolskee, 0 Zetterstrom, S-E Dahlen1211 How many times per day should peak expiratory flow rates be assessed when investigating occupational asthma?
J-L Malo, J Coti, A Cartier, L-P Boulet, J L'Archev&que,M Chan-Yeung1218 Is exercise testing useful in a community based asthma survey? TK Ninian, G Russell1222 Relation of HIV-I in bronchoalveolar lavage cells to abnormalities of lung function and to the presence of
Pneumocystis pneumonia in HIV-I seropositive patients J R Clarke, I K Taylor, J Fleming, J D Williamson,DM Mitchell
1227 Value of bacterial antigen detection in the diagnostic yield of transthoracic needle aspiration in severe communityacquired pneumonia F Bella, J Tort, M-A Morera, Y EspauleUa, YArmengol
1230 Correlation ofGM-CSF mRNA in bronchoalveolar fluid with indices of clinical activity in sarcoidosis A Itoh,E Yamaguchi, K Furuya, N Hizawa, N Ohnuma, YKawakami, N Kuzumaki
1235 Kinetics and cellular localisation of putrescine uptake in human lung tissue PHM Hoet, D Dinsdale, C P L Lewis,EK Verbeken, YM Lauweryns, B Nemeiy
1242 Identificationwof sleep disruption and sleep disordered breathing from the systolic blood pressure profileR 0O Davies, K Vardi-Visy, M Clarke, J R Stradling
1248 Investigation and management of pulmonary infiltrates following bone marrow transplantation: an eight yearreviewYH Campbell, N Blessing, A K Burnett, R D Stevenson
1252 Endocrine cells in diffuse pulmonary fibrosis NJ E Wilson, J R Gosney, F MayaUl1257 Tuberculin testing in residential homes for the elderlyM Nisar, C SD Williams, D Ashby, PD 0 Davies1261 Chlamydia pneumoniae seroprevalence in immunocompetent and immunocompromised populations in Milan
F Blasi, R Cosentini, M Clerici Schoeller, A Lupo, L AlegraReview series
1264 Pulmonary rehabilitation in chronic respiratory insufficiency: 5-home mechanical ventilation J-F Muir
Technical note1274 Respiratory gas exchange using a triaxial alveolar gas diagramY F Fuster, T Pages, L Palacios
Short reports1276 Long term survival in non-encapsulated primary liposarcoma of the mediastinum R G Grewal, K Prager,
J HM Austin, H Rotterdam1278 Gastropleural fistula following pulmonary resection PA O'Keefe, P Goldstraw1280 Use of continuous positive airway pressure in the management of community acquired pneumonia A Brett,
D G Sinclair1281 Endobronchial nocardial infectionKD McNeil, D WJohnson, WA Oliver1283 Mycobacterial contamination of fibreoptic bronchoscopes NM Brown, EA HeUyar, J E Harvey, D S Reeves
1285 Unilateral wheeze caused by pseudomembranous aspergillus tracheobronchitis in the immunocompromised patientR C Tait, B R O'Driscoll, D WDenning
1287 Pulmonary nodules due to systemic amyloidosis (AA) in Crohn's disease T WBeer, C WEdwards
Letters to the editor1289 Accuracy of the typical computed tomographic apppearances of fibrosing alveolitis P Brown, C Selby * Respiratory
symptoms questionnaire for asthma epidemiology: validity and reproducibility KPMcKinley, KM VenablesDiagnostic rigid and flexible oesophagoscopy in carcinoma of the oesophagus: a comparison L R Murmu
Miscellaneous1288 Book notice1289 Notices1290 Annual report1292 Indexes for 1993
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