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Table S2. Genes regulated more than 3-fold absolute change following NF54 WT (WT) relative to bloodfed (BF) or Pfs47 KO (KO) relative to BF at 26 hours post-infection. Duplicate gene ID entries represent multiple probes for the same gene.

Gene ID FC AbsWT/BF

FC AbsKO/BF

Description Functional Class

AGAP013235 103.78238 AGAP012536-PA Anopheles gambiae str. PEST Uc

AGAP000151 95.17855 Hypothetical secreted protein precursor - signalP detected s/

AGAP000151 68.54851 Hypothetical secreted protein precursor - signalP detected s/

AGAP000151 62.739994 Hypothetical secreted protein precursor - signalP detected s/

AGAP011026 19.49875 5' nucleotidase - signalP detected s/met/nuc 5'

AGAP005689 14.572665 Trypsin-like serine protease - signalP detected s/protease

AGAP005691 14.0656805 Trypsin-like serine protease - signalP detected s/protease

AGAP008291 11.834447 Trypsin - signalP detected s/met/aa Trypsin

AGAP012842 11.431733 Trypsin-5 pm/protease

AGAP012842 11.039069 Trypsin-5 pm/protease

AGAP001768 10.498411 Gamma-interferon inducible lysosomal thiol reductase - signalP detected s/imm Gamma-interferon

AGAP004383 10.440252 glutathione S-transferase D10 detox

AGAP001198 10.1015415 serine proteinase - signalP detected s/protease

AGAP006417 10.078912 SCP_euk: SCP-like extracellular protein domain s/antigen5

AGAP007858 9.871112 Lysyl-tRNA synthetase (class II) ps

AGAP005686 9.704747 Trypsin-like serine protease - signalP detected s/protease

AGAP004383 9.60058 glutathione S-transferase D10 detox

AGAP005689 9.585666 Trypsin-like serine protease - signalP detected s/protease

AGAP012710 9.486515 Histone H2B - NuA4 histone acetyltransferase complex - lipid particle nr

AGAP0000151

9.4513235 Hypothetical secreted protein precursor - signalP detected s/

AGAP007159 9.25539 Alpha crystallins pm

AGAP009049 9.2104025 Chitinase met/carb

AGAP008291 9.061202 Trypsin - signalP detected s/met/aa Trypsin

AGAP005670 8.461481 Trypsin-like serine protease - signalP detected s/protease

AGAP001198 8.45171 serine proteinase - signalP detected s/protease

AGAP0000151

7.9903164 Hypothetical secreted protein precursor - signalP detected s/

AGAP002593 7.6491637 Apolipoprotein D/Lipocalin - signalP detected extmat

AGAP011950 7.5414495 caspase short class (AGAP011950-PA) Anopheles gambiae str. PEST st/apoptosis

AGAP004334 7.1401844 Hypothetical secreted protein precursor - signalP detected s/

AGAP005691 6.7542453 Trypsin-like serine protease - signalP detected s/protease

AGAP010781 6.7329035 Furin 2 - ATP binding - protein amino acid phosphorylation - transmembrane receptor protein tyrosine kinase - transmembrane receptor protein

st

AGAP011950 6.699078 caspase short class (AGAP011950-PA) Anopheles gambiae str. PEST st/apoptosis

AGAP000586 6.590008 hypothetical protein AND_17723 uc

AGAP010198 6.393273 Ribonucleotide reductase, alpha subunit met/nuc

AGAP004916 6.3426857 Ficolin - signalP detected s/imm Ficolin

AGAP010781 6.250681 Furin 2 - ATP binding - protein amino acid phosphorylation - transmembrane receptor protein tyrosine kinase - transmembrane receptor protein

st

AGAP011950 6.178597 caspase short class (AGAP011950-PA) Anopheles gambiae str. PEST st/apoptosis

AGAP008292 6.048119 Trypsin - signalP detected s/met/aa Trypsin

AGAP005669 5.957252 Trypsin-like serine protease - signalP detected s/protease

AGAP006818 5.752401 Ribonucleotide reductase, beta subunit met/nuc

AGAP003357 5.688296 Conserved plasma membrane protein - 7 predicted membrane helices uc/memb membrane

AGAP012710 5.6227217 Histone H2B - NuA4 histone acetyltransferase complex - lipid particle nr

AGAP005260 5.6183386 Thymidylate kinase/adenylate kinase met/nuc

AGAP009049 5.5753984 Chitinase met/carb

AGAP005335 5.546234 Hypothetical secreted protein precursor - signalP detected s/

AGAP010198 5.460812 Ribonucleotide reductase, alpha subunit met/nuc

AGAP011980 5.377511 Conserved plasma membrane protein - 2 predicted membrane helices uc/memb membrane

AGAP011950 5.2079606 caspase short class (AGAP011950-PA) Anopheles gambiae str. PEST st/apoptosis

AGAP003230 5.041447 NAD+ ADP-ribosyltransferase Parp, required for poly-ADP ribosylation of nuclear

tm

AGAP004880 5.03591 Lactate dehydrogenase met/energy

AGAP005056 5.021069 CDK9 kinase-activating protein cyclin T st

AGAP000834 5.002775 Conserved plasma membrane protein - 12 predicted membrane helices uc/memb membrane

AGAP008915 5.0007005 Gamma-glutamyltransferase - signalP detected s/met/aa Gamma-glutamyltransferase

AGAP006677 4.951603 Trypsin-like serine protease - signalP detected s/protease

AGAP002593 4.9406204 Apolipoprotein D/Lipocalin - signalP detected extmat

AGAP013202 4.8186026 Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p - extracellular region - fungal-type cell wall - biological_process - - signalP detected

extmat

AGAP010363 4.8121343 Chitin-binding domain type 2 - signalP detected extmat

AGAP003758 4.7701764 AGAP003758-PA Anopheles gambiae str. PEST uc

AGAP001245 4.691351 Trypsin-like serine protease - signalP detected s/protease

AGAP004743 4.656021 cargo transport protein EMP24 (p24 protein family) - signalP detected - 2 predicted membrane helices

pe membrane

AGAP006522 4.630528 Vesicle coat complex COPI, zeta subunit pe

AGAP009045 4.5342183 Hypothetical secreted protein precursor - signalP detected s/

AGAP007335 4.5226965 E3 ubiquitin ligase involved in syntaxin degradation prot

AGAP007827 4.500448 Enolase met/carb

AGAP007158 4.4920444 Alpha crystallins pm

AGAP006799 4.4878664 Ferredoxin met/energy

AGAP006048 4.4658155 Cytochrome P450 CYP4/CYP19/CYP26 subfamilies - signalP detected detox/ox

AGAP001421 4.3955903 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit nr

AGAP012873 4.38718 cycle - response to starvation - circadian regulation of gene expression - DNA binding - negative regulation of transcription from RNA polymerase II

tm

AGAP008293 4.385232 Trypsin - signalP detected s/met/aa Trypsin

AGAP002917 4.3654594 AGAP002917-PA Anopheles gambiae str. PEST uc

AGAP003807 4.3601933 Trypsin-like serine protease - signalP detected s/protease

AGAP008293 4.348593 Trypsin - signalP detected s/met/aa Trypsin

AGAP005369 4.3193974 Dosage compensation complex, subunit MLE tm

AGAP011885 4.270402 tRNA splicing endonuclease ps

AGAP013202 4.2528863 Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p - extracellular region - fungal-type cell wall - biological_process - - signalP detected

extmat

AGAP004206 4.2528224 AGAP004206-PA Anopheles gambiae str. PEST uc

AGAP011615 4.1775327 Chitin binding Peritrophin-A domain - signalP detected extmat

AGAP005260 4.147243 Thymidylate kinase/adenylate kinase met/nuc

AGAP010159 4.139983 dUTPase met/nuc

AGAP001974 4.0925155 Predicted seven transmembrane receptor - rhodopsin family - 7 predicted membrane helices

st membrane

AGAP011981 4.0920095 Hypothetical secreted protein precursor - signalP detected s/

AGAP006612 4.0286136 60S ribosomal protein L29 Culex quinquefasciatus ps

AGAP002564 4.0014677 Fructose-biphosphate aldolase met/carb

AGAP002496 3.978326 E3 ubiquitin ligase, VHL component (von Hippel-Lindau tumor suppressor in humans)

pm

AGAP002690 3.9680455 DNA-binding subunit of a DNA-dependent protein kinase (Ku70 autoantigen) nr

AGAP006267 3.9478147 Hypothetical secreted protein precursor - signalP detected s/

AGAP006594 3.9190316 Permease of the major facilitator superfamily - 12 predicted membrane helices

met/carb membrane

AGAP006818 3.9181678 Ribonucleotide reductase, beta subunit met/nuc

AGAP002690 3.9165776 DNA-binding subunit of a DNA-dependent protein kinase (Ku70 autoantigen) nr

AGAP012763 3.9049065 CDK9 kinase-activating protein cyclin T st

AGAP003230 3.8963516 NAD+ ADP-ribosyltransferase Parp, required for poly-ADP ribosylation of nuclear

tm

AGAP004752 3.856655 Methyltransferase-like protein uc

AGAP007371 3.8472574 Hypothetical secreted protein precursor - signalP detected s/

AGAP007893 3.8155012 Conserved plasma membrane protein - 2 predicted membrane helices uc/memb membrane

AGAP008523 3.7985113 tRNA cytosine-5-methylases ps

AGAP013533 3.7644744 Haemolymph juvenile hormone binding protein - signalP detected s/

AGAP013533 3.7132466 Haemolymph juvenile hormone binding protein - signalP detected s/

AGAP008950 3.6767309 Conserved plasma membrane protein - 6 predicted membrane helices uc/memb membrane

AGAP004606 3.6676342 Huntingtin interacting protein HYPK uc

AGAP005706 3.6573365 Trypsin-like serine protease - signalP detected s/protease

AGAP006275 3.6545994 Hypothetical secreted protein precursor - signalP detected s/

AGAP005056 3.6491897 CDK9 kinase-activating protein cyclin T st

AGAP008481 3.6433675 ribonuclease P protein subunit p30 Culex quinquefasciatus met/nuc

AGAP011058 3.637127 AGAP011058-PA Anopheles gambiae str. PEST uc

AGAP007618 3.6365097 AGAP007618-PA Anopheles gambiae str. PEST uc

AGAP003926 3.6343615 Puromycin-sensitive aminopeptidase - signalP detected s/met/aa Puromycin-sensitive

AGAP003926 3.6336925 Puromycin-sensitive aminopeptidase - signalP detected s/met/aa Puromycin-sensitive

AGAP006267 3.6293008 Hypothetical secreted protein precursor - signalP detected s/

AGAP007844 3.6280036 Aspartyl-tRNA synthetase Translation ps

AGAP013386 3.623381 DNA polymerase zeta, catalytic subunit nr

AGAP011637 3.613269 Spliceosomal protein snRNP-U1A/U2B tm

AGAP004709 3.6063602 mitochondrial ribosomal protein, L17, Aedes aegypti ps

AGAP003987 3.5979295 Complement component 1, Q subcomponent binding protein/mRNA splicing factor SF2, subunit P32

imm

AGAP003331 3.5952468 Enolase-phosphatase E-1 met/aa

AGAP008992 3.5922503 AGAP008992-PA Anopheles gambiae str. PEST uc

AGAP001152 3.5741475 transcription factor FET5 tf

AGAP008094 3.5553365 Presenilin enhancer-2 subunit of gamma secretase - 2 predicted membrane helices - Membrane anchor detected

uc/anchor membrAnchor

AGAP004362 3.543489 Glutamate/leucine/phenylalanine/valine dehydrogenases met/aa

AGAP000468 3.522037 similar to SP:Q00451:PRF1_LYCES 36.4 kDa proline-rich protein Lycopersicon esculentum, proline-rich cell wall protein (Medicago sativa) GI:3818416; - signalP detected

s/protinh

AGAP013386 3.5074167 DNA polymerase zeta, catalytic subunit nr

AGAP001777 3.500577 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily - 9 predicted membrane helices

detox membrane

AGAP004880 3.4966652 Lactate dehydrogenase met/energy

AGAP008582 3.4908454 Glycosyl hydrolase, family 38 - alpha-mannosidase - signalP detected s/met/carb Glycosyl

AGAP001933 3.4787982 serine/threonine-protein kinase vrk Aedes aegypti st

AGAP013519 3.47355 Small nuclear ribonucleoprotein (snRNP) LSM3 tm

AGAP008013 3.4642336 Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p - osmosensor - 1,3-beta-glucan biosynthetic process - signalP detected

s/mucin extmat

AGAP000732 3.438675 synaptic vesicle protein Aedes aegypti - 12 predicted membrane helices pe membrane

AGAP010099 3.4237702 cuticular protein 84, RR-2 family (AGAP010100-PA) Anopheles gambiae str. PEST - signalP detected

extmat

AGAP003758 3.4194767 AGAP003758-PA Anopheles gambiae str. PEST uc

AGAP011403 3.3985167 GDNF-inducible zinc finger protein 1 - intracellular - zinc ion binding - protein binding - negative regulation of transcription from RNA polymerase

tm

AGAP013609 3.389286

AGAP011159 3.3872287 Cytochrome c oxidase subunit Va met/energy

AGAP005478 3.3754163 AGAP005478-PA Anopheles gambiae str. PEST uc

AGAP005335 3.360142 Hypothetical secreted protein precursor - signalP detected s/

AGAP012000 3.334291 Ficolin - signalP detected s/imm Ficolin

AGAP007747 3.317692 Hypothetical secreted protein precursor - signalP detected s/

AGAP010644 3.3164594 mitochondrial 39S ribosomal protein L39 Culex quinquefasciatus ps

AGAP012957 3.2939422 Cytochrome P450 CYP4/CYP19/CYP26 subfamilies - signalP detected detox/ox

AGAP004563 3.2693443 Angiotensin I-converting enzymes - M2 family peptidases - signalP detected s/met/aa Angiotensin

AGAP000679 3.2570648 Aminoacylase ACY1 met/aa

AGAP006191 3.250343 Chitinase met/carb

AGAP010716 3.2375274 Conserved plasma membrane protein - 2 predicted membrane helices uc/memb membrane

AGAP002583 3.2324138 Hypothetical secreted protein precursor - signalP detected s/

AGAP001974 3.2304375 Predicted seven transmembrane receptor - rhodopsin family - 7 predicted membrane helices

st membrane

AGAP006630 3.2260115 6.3 kDa salivary peptide - signalP detected s/

AGAP008798 3.2202091 small GTPase mediated signal transduction - cellular_component - guanyl-nucleotide exchange factor - zinc ion binding - vesicle-mediated transport

pe

AGAP010816 3.2189617 CD109 antigen - serine-type endopeptidase inhibitor - extracellular space - extracellular region - protein binding - plasma membrane - anchored to - signalP detected

s/protinh

AGAP009701 3.218345 Alanyl-tRNA synthetase ps

AGAP009660 3.2085764 Adenylate kinase met/nuc

AGAP005265 3.2048526 Domain in histone families 1 and 5 nr

AGAP006267 3.2019393 Hypothetical secreted protein precursor - signalP detected s/

AGAP005371 3.188427 Acetylcholinesterase/Butyrylcholinesterase - signalP detected st

AGAP010081 3.1836143 AGAP010081-PA Anopheles gambiae str. PEST - 21 NetOglyc sites uc

AGAP002713 3.1714168 mitochondrial ribosomal protein, L49, Aedes aegypti ps

AGAP003488 3.1683037 Armadillo/beta-catenin-like repeat-containing protein - signalP detected pm

AGAP012914 3.1418285 Prefoldin alpha subunit pm

AGAP009660 3.1410315 Adenylate kinase met/nuc

AGAP012982 3.1318173 rhodopsin receptor 3 (AGAP001163-PA) Anopheles gambiae str. PEST - 7 predicted membrane helices

st membrane

AGAP006044 3.126019 STE20-like serine/threonine kinase MST st

AGAP010896 3.112382 F29D11.1 CE05765 WBGene00003071 locus:lrp-1 low density lipid receptor-rlated protein status:Partially_confirmed UniProt:Q04833 protein_id:CAA98124.1

st

AGAP009234 3.1084862 Mitochondrial translation elongation factor EF-Tsmt, catalyzes nucleotide exchange on EF-Tumt

ps

AGAP012302 3.1042728 Sulfate/bicarbonate/oxalate exchanger SAT-1 - 9 predicted membrane helices tr membrane

AGAP013398 3.1040995 Conserved secreted protein precursor - signalP detected s/ucs

AGAP007371 3.1040595 Hypothetical secreted protein precursor - signalP detected s/

AGAP004161 3.1036794 AGAP004161-PA Anopheles gambiae str. PEST uc

AGAP011733 3.0891314 Conserved plasma membrane protein - 3 predicted membrane helices uc/memb membrane

AGAP003581 3.0720053 Sorbitol dehydrogenase detox

AGAP008658 3.067331 AGAP008658-PA Anopheles gambiae str. PEST uc

AGAP002967 3.0497336 ATP-dependent DNA helicase nr

AGAP010479 3.0466778 Hypothetical secreted protein precursor - signalP detected s/

AGAP006707 3.0389297 Trypsin-like serine protease - signalP detected s/protease

AGAP002950 3.033513 hypothetical protein AaeL_AAEL006183 Aedes aegypti uc

AGAP000523 3.0325644 ATP synthase lipid-binding protein, mitochondrial - mitochondrial membrane - mitochondrion - mitochondrial proton-transporting ATP synthase complex - - 2 predicted membrane helices

tr membrane

AGAP002804 3.0115817 Niemann-Pick type C2 - signalP detected s/imm Niemann-Pick

AGAP003537 -8.479611 bric a brac 1 - protein binding - regulation of transcription - negative regulation of developmental pigmentation - regulation of developmental - 11 NetOglyc sites

tm

AGAP002905 -7.352332 odorant binding protein (AGAP002905-PA) Anopheles gambiae str. PEST - signalP detected OBP

s/OBP

AGAP010047 -7.059107 Hypothetical secreted protein precursor - signalP detected s/

AGAP005840 -5.62455 AGAP005840-PA Anopheles gambiae str. PEST - 17 NetOglyc sites uc

AGAP006174 -5.5717125 Calmodulin st

AGAP012985 -5.0277867 rhodopsin receptor 3 (AGAP001163-PA) Anopheles gambiae str. PEST - 7 predicted membrane helices

st membrane

AGAP000376 -4.9208345 Hypothetical secreted protein precursor - signalP detected s/

AGAP010731 -4.7624598 CLIP-domain serine protease subfamily A (AGAP010731-PA) Anopheles gambiae str. PEST - signalP detected

s/protease

AGAP005156 -4.3876815 retained - male courtship behavior - axon guidance - regulation of female receptivity - salivary gland development - transcription activator - - 15 NetOglyc sites

tm

AGAP011084 -4.1926856 ATP-dependent RNA helicase tm

AGAP001474 -4.1510267 Dromyosuppressin - neuropeptide signaling pathway - negative regulation of heart contraction - neuropeptide hormone - signalP detected

st

AGAP008922 -4.119931 6.9 kDa salivary secreted peptide - signalP detected s/

AGAP004723 -4.1174383 Chromobox protein homolog 3 - nuclear centromeric heterochromatin - protein domain specific binding - negative regulation of transcription - spindle

tm

AGAP003740 -3.8404331 AGAP003740-PA Anopheles gambiae str. PEST uc

AGAP007303 -3.6307268 Hypothetical secreted protein precursor - signalP detected s/

AGAP001511 -3.60473 Transcription regulator dachshund, contains SKI/SNO domain - signalP detected

tm

AGAP000054 -3.5667439 Leucine-rich repeat protein uc

AGAP004036 -3.563713 peroxinectin Culex quinquefasciatus - signalP detected detox/ox

AGAP012985 -3.4239461 rhodopsin receptor 3 (AGAP001163-PA) Anopheles gambiae str. PEST - 7 predicted membrane helices

st membrane

AGAP008368 -3.4001105 CD109 antigen - serine-type endopeptidase inhibitor - extracellular space - extracellular region - protein binding - plasma membrane - anchored to

s/protinh

AGAP011966 3.3937225 RNA polymerase II transcription termination factor TTF2/lodestar, DEAD-box superfamily

tm

AGAP007523 -3.3680778 Myosin class II heavy chain cs

AGAP007552 -3.3667853 U2-associated snRNP A' protein - 24 NetOglyc sites tm

AGAP012087 -3.345633 bicoid-interacting protein 3 - olfactory behavior - regulation of transcription - nucleus - protein binding - protein amino acid methylation -

tm

AGAP007170 -3.3052766 AGAP007170-PA Anopheles gambiae str. PEST - 13 NetOglyc sites uc

AGAP006731 -3.200024 Uncharacterized conserved protein, contains laminin, cadherin and EGF st

AGAP009656 -3.1552706 AGAP009656-PA Anopheles gambiae str. PEST uc

AGAP006380 -3.1363323 Lipid exporter ABCA1 - 10 predicted membrane helices met/lipd membrane

AGAP011791 -3.1223803 CLIP-domain serine protease subfamily A (AGAP011791-PA) Anopheles gambiae str. PEST - signalP detected

s/protease

AGAP009217 -3.0700402 CLIP-domain serine protease subfamily B (AGAP009217-PA) Anopheles gambiae str. PEST - signalP detected

s/protease

AGAP012155 -3.023349 Lipid exporter ABCA1 - 14 predicted membrane helices met/lipd membrane

AGAP004988 117.70919 Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p - extracellular region - fungal-type cell wall - biological_process - - signalP detected

extmat

AGAP004987 33.684986 female sterile (1) homeotic - negative regulation of gene-specific transcription - terminal region determination - protein kinase - DNA binding - - signalP detected

tm

AGAP006602 11.433131 Hypothetical secreted protein precursor - signalP detected s/

AGAP007748 8.714999 Hypothetical secreted protein precursor - signalP detected s/

AGAP011753 8.556366 AGAP011753-PA Anopheles gambiae str. PEST uc

AGAP013104 7.9369674 AGAP012536-PA Anopheles gambiae str. PEST uc

AGAP007746 6.5122023 Hypothetical secreted protein precursor - signalP detected s/

AGAP007990 6.0001225 UDP-glucuronosyl and UDP-glucosyl transferase - signalP detected - 2 predicted membrane helices

met/carb membrane

AGAP010813 5.6310053 Hypothetical secreted protein precursor - signalP detected s/

AGAP008645 4.820219 Hypothetical secreted protein precursor - signalP detected s/

AGAP005501 4.790435 Predicted dehydrogenase detox

AGAP012279 4.7303977 Amiloride-sensitive sodium channel tr

AGAP007347 4.314009 Alpha-lactalbumin / lysozyme C - signalP detected s/imm Alpha-lactalbumin

AGAP006603 4.134049 Hypothetical secreted mucin - signalP detected s/mucin

AGAP007990 4.131758 UDP-glucuronosyl and UDP-glucosyl transferase - signalP detected - 2 predicted membrane helices

met/carb membrane

AGAP002769 4.0708137 Uncharacterized protein C5orf4 - iron ion binding - fatty acid biosynthetic process - oxidoreductase - integral to membrane - oxidation reduction -

met/lipd

AGAP007104 3.6089995 Polyprenyl synthetase met/int

AGAP013359 3.5055258 Hypothetical secreted protein precursor - signalP detected s/

AGAP008054 3.4748445 Insect pheromone-binding family - signalP detected s/

AGAP010934 3.460939 Ankyrin extmat

AGAP006991 3.3517544 Hypothetical secreted protein precursor - signalP detected s/

AGAP003995 3.3212812 Maltase glucoamylase - signalP detected s/met/carb Maltase

AGAP013459 3.3190067 Hypothetical secreted protein precursor - signalP detected s/

AGAP007347 3.2909606 Alpha-lactalbumin / lysozyme C - signalP detected s/imm Alpha-lactalbumin

AGAP002690 3.2786028 DNA-binding subunit of a DNA-dependent protein kinase (Ku70 autoantigen) nr

AGAP001390 3.2681725 Notch homolog 1, translocation-associated (Drosophila) - regulation of epithelial cell proliferation involved in prostate gland development - - signalP detected

st/apoptosis

AGAP004771 3.2673302 Mucin-5AC - extracellular matrix structural constituent - extracellular region - fibril - cell adhesion - fibril organization - digestion - 139 NetOglyc sites

extmat

AGAP003493 3.250789 Predicted transporter (major facilitator superfamily) - 12 predicted membrane helices

tr membrane

AGAP012166 3.1943147 Phosphatidylinositol transfer protein SEC14 met/lipd

AGAP010863 3.1920595 Hypothetical secreted mucin - signalP detected s/mucin

AGAP011216 3.1056876 oxidase/peroxidase Aedes aegypti detox/ox

AGAP006416 3.0760503 Serine protease SP24D - signalP detected - 2 predicted membrane helices s/protease membrane

AGAP006194 3.0580213 Farnesoic acid 0-methyl transferase - signalP detected s/met/lipd Farnesoic

AGAP000338 3.0250657 isoprenoid biosynthetic process - cholesterol biosynthetic process - cytoplasm - phosphomevalonate kinase

met/lipd

AGAP012166 3.0000463 Phosphatidylinositol transfer protein SEC14 met/lipd

AGAP005829 -58.559406 Microtubule-binding protein involved in cell cycle control nr

AGAP008410 -54.225304 AGAP008410-PA Anopheles gambiae str. PEST uc

AGAP006241 -52.22314 Innexin - 3 predicted membrane helices extmat membrane

AGAP004038 -44.856796 Chorion peroxidase - signalP detected detox/ox

AGAP007365 -43.951775 exuperantia - precatalytic spliceosome - nuclear mRNA splicing, via spliceosome - anterior/posterior axis specification, embryo - regulation of pole

tm

AGAP004038 -41.598236 Chorion peroxidase - signalP detected detox/ox

AGAP007767 -41.468674 AGAP007767-PA Anopheles gambiae str. PEST uc

AGAP007959 -41.011997 AGAP007959-PA Anopheles gambiae str. PEST uc

AGAP008040 -39.4984 AGAP008040-PA Anopheles gambiae str. PEST uc

AGAP003087 -38.557 Conserved plasma membrane protein - signalP detected - 4 predicted membrane helices

uc/memb membrane

AGAP004962 -35.68563 Cyclin B nr

AGAP007365 -34.655598 exuperantia - precatalytic spliceosome - nuclear mRNA splicing, via spliceosome - anterior/posterior axis specification, embryo - regulation of pole

tm

AGAP004036 -33.689873 peroxinectin Culex quinquefasciatus - signalP detected detox/ox

AGAP006609 -33.634632 Synaptic vesicle transporter SVOP - 11 predicted membrane helices tr membrane

AGAP000835 -33.389294 UDP-N-acetylglucosamine transferase subunit ALG13 homolog - carbohydrate metabolic process - carbohydrate binding -

met/carb

AGAP006609 -32.868362 Synaptic vesicle transporter SVOP - 11 predicted membrane helices tr membrane

AGAP007280 -32.3322 nudel - egg activation - peptidase - proteolysis - extracellular region - serine-type endopeptidase - oocyte dorsal/ventral axis specification - 31 NetOglyc sites

pm/protease

AGAP004038 -31.597448 Chorion peroxidase - signalP detected detox/ox

AGAP009976 -31.503962 Conserved plasma membrane protein - 2 predicted membrane helices - Membrane anchor detected

uc/memb membrane membrAnchor

AGAP010789 -31.23779 Notch - regulation of cell differentiation - eye-antennal disc development - R1/R6 cell differentiation - germ-line stem cell maintenance - protein

tm

AGAP009976 -27.585844 Conserved plasma membrane protein - 2 predicted membrane helices - Membrane anchor detected

uc/memb membrane membrAnchor

AGAP007767 -26.895428 AGAP007767-PA Anopheles gambiae str. PEST uc

AGAP009216 -26.697138 CLIP-domain serine protease subfamily B (AGAP009217-PA) Anopheles gambiae str. PEST

pm/protease

AGAP009751 -25.843576 Angiotensin I-converting enzymes - M2 family peptidases met/aa

AGAP011235 -24.481003 Predicted histone tail methylase containing SET domain nr

AGAP010547 -24.460855 Trypsin-like serine protease pm/protease

AGAP010046 -24.10335 Hypothetical secreted protein precursor - signalP detected s/

AGAP004036 -23.98012 peroxinectin Culex quinquefasciatus - signalP detected detox/ox

AGAP006480 -23.906822 Conserved plasma membrane protein - signalP detected - 2 predicted membrane helices

uc/memb membrane

AGAP004963 -23.638897 Cyclin B nr

AGAP000835 -23.137173 UDP-N-acetylglucosamine transferase subunit ALG13 homolog - carbohydrate metabolic process - carbohydrate binding -

met/carb

AGAP007300 -22.967684 Alkaline phosphatase homologues st

AGAP004638 -22.966158 clip-domain serine protease, Aedes aegypti - signalP detected s/protease

AGAP010046 -22.815454 Hypothetical secreted protein precursor - signalP detected s/

AGAP006023 -22.20682 Aromatic amino acid hydroxylase met/aa

AGAP012577 -22.183397 cathepsin l Culex quinquefasciatus - signalP detected pm

AGAP001124 -20.464487 Aminomethyl transferase met/aa

AGAP008040 -20.434639 AGAP008040-PA Anopheles gambiae str. PEST uc

AGAP008912 -19.994883 GTPase-activating protein uc

AGAP000427 -19.9703 Low-density lipoprotein receptors containing Ca2+-binding EGF-like st

AGAP010547 -19.310526 Trypsin-like serine protease pm/protease

AGAP007320 -19.100266 Conserved plasma membrane protein - 4 predicted membrane helices uc/memb membrane

AGAP008912 -18.843801 GTPase-activating protein uc

AGAP004638 -18.757132 clip-domain serine protease, Aedes aegypti - signalP detected s/protease

AGAP004638 -18.587723 clip-domain serine protease, Aedes aegypti - signalP detected s/protease

AGAP007300 -18.583214 Alkaline phosphatase homologues st

AGAP010831 -18.272266 KOG1366, KOG1366, Alpha-macroglobulin Posttranslational modification, protein turnover, chaperones

pm

AGAP005829 -17.733114 Microtubule-binding protein involved in cell cycle control nr

AGAP004719 -17.702873 Trypsin-like serine protease - signalP detected s/protease

AGAP007411 -17.60149 C-type lectin domain family 4, member f - integral to membrane - membrane - endocytosis - sugar binding - binding - receptor - signalP detected

st

AGAP004638 -17.468447 clip-domain serine protease, Aedes aegypti - signalP detected s/protease

AGAP009216 -17.29522 CLIP-domain serine protease subfamily B (AGAP009217-PA) Anopheles gambiae str. PEST

pm/protease

AGAP006241 -16.273258 Innexin - 3 predicted membrane helices extmat membrane

AGAP004802 -16.215267 4-hydroxyphenylpyruvate dioxygenase met/aa

AGAP012974 -16.144 dentin matrix protein 1 - extracellular matrix binding - positive regulation of cell-substrate adhesion - extracellular matrix organization - - signalP detected

extmat

AGAP010197 -16.13331 SOCS box protein SSB-1, contains SPRY domain uc

AGAP006827 -15.96508 AGAP006827-PA Anopheles gambiae str. PEST - 18 NetOglyc sites uc

AGAP011897 -15.959065 AGAP011897-PA Anopheles gambiae str. PEST uc

AGAP001127 -15.687529 Membrane glycoprotein LIG-1 - signalP detected s/imm Membrane

AGAP010547 -15.650125 Trypsin-like serine protease pm/protease

AGAP003545 -15.65007 AGAP003545-PA Anopheles gambiae str. PEST uc

AGAP001544 -15.636089 Predicted E3 ubiquitin ligase - 31 NetOglyc sites pm

AGAP005733 -15.560942 AGAP005733-PA Anopheles gambiae str. PEST uc

AGAP006989 -15.527342 Kinesin-like protein cs

AGAP003960 -15.319267 Trypsin-like serine protease - signalP detected s/protease

AGAP009146 -15.084766 Hypothetical secreted protein precursor - signalP detected s/

AGAP010280 -14.882358 Hypothetical secreted protein precursor - signalP detected s/

AGAP012017 -14.66701 AGAP012017-PA Anopheles gambiae str. PEST uc

AGAP001336 -14.567678 Sugar transporter/spinster transmembrane protein - signalP detected - 10 predicted membrane helices

tr membrane

AGAP000879 -14.489798 Hypothetical secreted protein precursor - signalP detected s/

AGAP004263 -14.423104 Haemolymph juvenile hormone binding protein - signalP detected s/

AGAP006370 -14.373859 Dosage compensation complex, subunit MLE - signalP detected tm

AGAP003331 -14.233737 Enolase-phosphatase E-1 met/aa

AGAP010531 -14.181266 Ficolin - signalP detected s/imm Ficolin

AGAP003354 -14.068886 SCP_euk: SCP-like extracellular protein domain - signalP detected s/antigen5

AGAP012352 -13.916405 ML domain - signalP detected s/imm ML

AGAP003331 -13.718863

5

Enolase-phosphatase E-1 met/aa

AGAP007454 -13.565626 Membrane glycoprotein LIG-1 - signalP detected s/imm Membrane

AGAP003515 -13.420917 Carbon-nitrogen hydrolase met/aa

AGAP010545 -13.400516

5

Trypsin-like serine protease pm/protease

AGAP005693 -13.358117 Membrane glycoprotein LIG-1 - signalP detected s/imm Membrane

AGAP005888 -13.205099 Catecholamines up - membrane - transmembrane transport - metal ion transmembrane transporter - metal ion transport - integral to plasma membrane - - signalP detected

tr

AGAP007313 -13.104965 Conserved plasma membrane protein - signalP detected - 4 predicted membrane helices

uc/memb membrane

AGAP000609 -12.969505 Hypothetical secreted protein precursor - signalP detected s/

AGAP007314 -12.936443 Conserved plasma membrane protein - 4 predicted membrane helices - Membrane anchor detected

uc/memb membrane membrAnchor

AGAP004018 -12.925081 Syntrophins (type gamma) - 15 NetOglyc sites extmat

AGAP004700 -12.909165 Trypsin-like serine protease - signalP detected s/protease

AGAP008638 -12.818421 Histone H1.0 - nucleus - chromosome - nucleosome assembly - Golgi apparatus - nucleosome - DNA binding

nr

AGAP009874 -12.697316 cuticular protein 76, RR-1 family (AGAP009874-PA) Anopheles gambiae str. PEST - signalP detected

extmat

AGAP011065 -12.660797 Transcription factor SIX tf

AGAP009751 -12.654149 Angiotensin I-converting enzymes - M2 family peptidases met/aa

AGAP005253 -12.638838 AGAP005253-PA Anopheles gambiae str. PEST uc

AGAP012040 -12.581551 Mucin-5AC - extracellular matrix structural constituent - extracellular region - fibril - cell adhesion - fibril organization - digestion - 18 NetOglyc sites

extmat

AGAP002632 -12.369202 Hypothetical secreted protein precursor - signalP detected s/

AGAP005952 -12.266135 AT4G18670 - structural constituent of cell wall - protein binding - signalP detected

extmat

AGAP004700 -12.228972 Trypsin-like serine protease - signalP detected s/protease

AGAP001377 -12.179789 serine protease inhibitor, non-inhibitory (AGAP001377-PA) Anopheles gambiae str. PEST - signalP detected

s/protinh

AGAP006404 -12.099557 AGAP006404-PA Anopheles gambiae str. PEST - 15 NetOglyc sites uc

AGAP000548 -12.035933 Hypothetical secreted protein precursor - signalP detected s/

AGAP001377 -11.970756 serine protease inhibitor, non-inhibitory (AGAP001377-PA) Anopheles gambiae str. PEST - signalP detected

s/protinh

AGAP010699 -11.927549 Chromatin remodeling complex WSTF-ISWI, small subunit tm

AGAP005245 -11.923935 Proteins containing BTB/POZ and Kelch , involved in regulatory/signal transduction processes

st

AGAP004638 -11.881237 clip-domain serine protease, Aedes aegypti - signalP detected s/protease

AGAP010280 -11.651319 Hypothetical secreted protein precursor - signalP detected s/

AGAP007505 -11.590027 Serine carboxypeptidases (lysosomal cathepsin A) - signalP detected s/met/aa Serine

AGAP011765 -11.455876 BPTI/Kunitz family of serine protease inhibitors - signalP detected s/protinh Kunitz

AGAP010531 -11.406027 Ficolin - signalP detected s/imm Ficolin

AGAP004963 -11.354855 Cyclin B nr

AGAP010547 -11.352271 Trypsin-like serine protease pm/protease

AGAP010530 -11.344721 Trypsin-like serine protease pm/protease

AGAP002198 -11.29748 Methyltransferases met/int

AGAP007453 -11.242775 Membrane glycoprotein LIG-1 - signalP detected s/imm Membrane

AGAP009221 -11.231308 serine protease inhibitor (AGAP009221-PA) Anopheles gambiae str. PEST - signalP detected

s/protinh

AGAP003691 -11.194934 serine protease Culex quinquefasciatus - signalP detected s/protease

AGAP004530 -11.124219 Leucine zipper tumor suppressor 2 - membrane - microtubule organizing center - positive regulation of cell death - mitosis - cytoplasm -

st/apoptosis

AGAP013221 -11.075045 Trypsin-like serine protease - signalP detected s/protease

AGAP001377 -11.022266 serine protease inhibitor, non-inhibitory (AGAP001377-PA) Anopheles gambiae str. PEST - signalP detected

s/protinh

AGAP003015 -10.928461 Argininosuccinate synthase met/aa

AGAP004324 -10.924269 Hypothetical secreted protein precursor - signalP detected s/

AGAP006803 -10.890633 Kinesin-like protein cs

AGAP013192 -10.885994 SCP_euk: SCP-like extracellular protein domain - signalP detected s/antigen5

AGAP013060 -10.865882 hypothetical protein AaeL_AAEL008802 Aedes aegypti - signalP detected s/

AGAP007320 -10.768253 Conserved plasma membrane protein - 4 predicted membrane helices uc/memb membrane

AGAP000650 -10.762423

5

Ribonuclease P 40kDa met/nuc

AGAP008738 -10.737859 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E - 11 NetOglyc sites

tr

AGAP010531 -10.712683 Ficolin - signalP detected s/imm Ficolin

AGAP003545 -10.677385 AGAP003545-PA Anopheles gambiae str. PEST uc

AGAP012900 -10.670447 Papain family cysteine protease pm/protease

AGAP002503 -10.658615 Acyl-CoA synthetase met/lipd

AGAP005766 -10.628974 Larval serum protein 1 beta - lipid particle - transport - oxygen transporter - nutrient reservoir - extracellular region - larval serum protein - signalP detected

tr

AGAP004719 -10.578614 Trypsin-like serine protease - signalP detected s/protease

AGAP001544 -10.507862 Predicted E3 ubiquitin ligase - 31 NetOglyc sites pm

AGAP000327 -10.47428 Tyrosine aminotransferase met/aa

AGAP007711 -10.399125 Conserved plasma membrane protein - 2 predicted membrane helices uc/memb membrane

AGAP009448 -10.3865 AGAP009448-PA Anopheles gambiae str. PEST uc

AGAP004036 -10.341766 peroxinectin Culex quinquefasciatus - signalP detected detox/ox

AGAP011065 -10.327399 Transcription factor SIX tf

AGAP012040 -10.323953 Mucin-5AC - extracellular matrix structural constituent - extracellular region - fibril - cell adhesion - fibril organization - digestion - 18 NetOglyc sites

extmat

AGAP004281 -10.322143 AGAP004281-PA Anopheles gambiae str. PEST uc

AGAP002503 -10.319077

5

Acyl-CoA synthetase met/lipd

AGAP004638 -10.206475 clip-domain serine protease, Aedes aegypti - signalP detected s/protease

AGAP007160 -10.199758 Alpha crystallins pm

AGAP009217 -10.153331 CLIP-domain serine protease subfamily B (AGAP009217-PA) Anopheles gambiae str. PEST - signalP detected

s/protease

AGAP004318 -10.132616 CLIP-domain serine protease subfamily C (AGAP004318-PA) Anopheles gambiae str. PEST - signalP detected

s/protease

AGAP003250 -10.07947 Trypsin - signalP detected s/met/aa Trypsin

AGAP005890 -10.072513 Hypothetical secreted protein precursor - signalP detected s/

AGAP001377 -10.028435 serine protease inhibitor, non-inhibitory (AGAP001377-PA) Anopheles gambiae str. PEST - signalP detected

s/protinh

AGAP009054 -9.922854 Possible membrane-associated motif in LPS-induced tumor necrosis factor alpha factor

imm

AGAP011507 -9.883312 Acetylcholinesterase/Butyrylcholinesterase st

AGAP002134 -9.867925 Serine/threonine-protein phosphatase 1 regulatory subunit 10 - zinc ion binding - protein binding - transcription regulator - transcription - - signalP detected

tm

AGAP004036 -9.817777 peroxinectin Culex quinquefasciatus - signalP detected detox/ox

AGAP005732 -9.768541 AGAP005732-PA Anopheles gambiae str. PEST uc

AGAP004534 -9.7532015 cathepsin b Aedes aegypti - signalP detected pm

AGAP004825 -9.752618 AGAP004825-PA Anopheles gambiae str. PEST uc

AGAP003775 -9.751035 AGAP003775-PA Anopheles gambiae str. PEST uc

AGAP003248 -9.749617 CLIP-domain serine protease subfamily B (AGAP003249-PA) Anopheles gambiae str. PEST - signalP detected

s/protease

AGAP012662 -9.691814 Carbon-nitrogen hydrolase met/aa

AGAP010814 -9.658356 KOG1366, KOG1366, Alpha-macroglobulin Posttranslational modification, protein turnover, chaperones - signalP detected

pm

AGAP008118 -9.639723 Serine/threonine protein kinase st

AGAP008810 -9.634033 Retinoid- and fatty acid-binding glycoprotein - microtubule associated complex - receptor binding - endocytic vesicle - lipid particle - Wnt receptor

cs

AGAP006909 -9.57981 serine protease inhibitor (AGAP006909-PA) Anopheles gambiae str. PEST - signalP detected

s/protinh

AGAP010047 -9.563679 Hypothetical secreted protein precursor - signalP detected s/

AGAP007455 -9.516598 Membrane glycoprotein LIG-1 - signalP detected s/imm Membrane

AGAP012571 -9.512158 hypothetical protein AaeL_AAEL008802 Aedes aegypti - signalP detected s/

AGAP008355 -9.498607 Anopheles gambiae str. PEST AGAP012553-PA Anopheles gambiae str. PEST uc

AGAP005693 -9.453353 Membrane glycoprotein LIG-1 - signalP detected s/imm Membrane

AGAP007454 -9.451931 Membrane glycoprotein LIG-1 - signalP detected s/imm Membrane

AGAP009221 -9.448366 serine protease inhibitor (AGAP009221-PA) Anopheles gambiae str. PEST - signalP detected

s/protinh

AGAP006823 -9.435069 AGAP006823-PA Anopheles gambiae str. PEST uc

AGAP013503 -9.419397 vitellogenin 2 - signalP detected storage/

AGAP004318 -9.400308 CLIP-domain serine protease subfamily C (AGAP004318-PA) Anopheles gambiae str. PEST - signalP detected

s/protease

AGAP005547 -9.394894 Alpha crystallins pm

AGAP008012 -9.375832 Hypothetical secreted mucin - signalP detected s/mucin

AGAP003486 -9.339586 nucleolar and coiled-body phosphoprotein 1 - positive regulation of transcription - regulation of protein import into nucleus - box H/ACA snoRNA - 23 NetOglyc sites

tm

AGAP008449 -9.3229475 cuticle protein Culex quinquefasciatus - signalP detected extmat

AGAP009670 -9.313692 serine protease inhibitor (AGAP009670-PB) Anopheles gambiae str. PEST - signalP detected

s/protinh

AGAP013186 -9.245031 Protein phosphatase 1, regulatory subunit, - signalP detected s/st Protein

AGAP010600 -9.22126 Hypothetical secreted protein precursor - signalP detected s/

AGAP004855 -9.220695 CLIP-domain serine protease subfamily B (AGAP004855-PA) Anopheles gambiae str. PEST - signalP detected

s/protease

AGAP003095 -9.202859 Hypothetical secreted protein precursor - signalP detected s/

AGAP011789 -9.155479 CLIP-domain serine protease subfamily A (AGAP011789-PA) Anopheles gambiae str. PEST - signalP detected

s/protease

AGAP003776 -9.119368 AGAP003776-PA Anopheles gambiae str. PEST uc

AGAP002720 -9.060272 Cysteine proteinase Cathepsin F - signalP detected pm

AGAP007453 -9.037006 Membrane glycoprotein LIG-1 - signalP detected s/imm Membrane

AGAP001753 -9.023059 15-hydroxyprostaglandin dehydrogenase met/lipd

AGAP009670 -9.002748 serine protease inhibitor (AGAP009670-PB) Anopheles gambiae str. PEST - signalP detected

s/protinh

AGAP007160 -8.956908 Alpha crystallins pm

AGAP007336 -8.905075 Cytoplasmic linker protein 190 - spindle microtubule - fusome - microtubule-based process - cellularization - Golgi apparatus - cell cortex

cs

AGAP013060 -8.892709 hypothetical protein AaeL_AAEL008802 Aedes aegypti - signalP detected s/

AGAP000999 -8.875668 Toll-like receptor (AGAP010669-PA) Anopheles gambiae str. PEST - signalP detected

s/imm Toll-like

AGAP012985 -8.82679 rhodopsin receptor 3 (AGAP001163-PA) Anopheles gambiae str. PEST - 7 predicted membrane helices

st membrane

AGAP003090 -8.80004 KOG0895, KOG0895, Ubiquitin-conjugating enzyme Posttranslational modification, protein turnover, chaperones

pm

AGAP003691 -8.778926 serine protease Culex quinquefasciatus - signalP detected s/protease

AGAP007456 -8.7754345 Membrane glycoprotein LIG-1 - signalP detected s/imm Membrane

AGAP010545 -8.768368 Trypsin-like serine protease pm/protease

AGAP003246 -8.761419 Trypsin - signalP detected s/met/aa Trypsin

AGAP010399 -8.744462 Flavin-containing monooxygenase detox

AGAP011219 -8.742361 Cell division cycle-associated protein 8 st

AGAP002198 -8.710751 Methyltransferases met/int

AGAP010530 -8.704709 Trypsin-like serine protease pm/protease

AGAP009128 -8.687556 Mitochondrial carrier protein - 3 predicted membrane helices met/energy membrane

AGAP010530 -8.687338 Trypsin-like serine protease pm/protease

AGAP010830 -8.655078 CD109 antigen - serine-type endopeptidase inhibitor - extracellular space - extracellular region - protein binding - plasma membrane - anchored to - signalP detected

s/protinh

AGAP008045 -8.647209 Transcription initiation factor IID subunit tm

AGAP010398 -8.631293 Flavin-containing monooxygenase detox

AGAP004263 -8.626088 Haemolymph juvenile hormone binding protein - signalP detected s/

AGAP008182 -8.623235 Haemolymph juvenile hormone binding protein - signalP detected s/

AGAP001323 -8.585333 AGAP001323-PA Anopheles gambiae str. PEST uc

AGAP007502 -8.580718 Kinesin-like protein cs

AGAP005767 -8.557229 Larval serum protein 1 beta - lipid particle - transport - oxygen transporter - nutrient reservoir - extracellular region - larval serum protein - signalP detected

tr

AGAP006098 -8.555769 Nanos uc

AGAP009940 -8.539414 AGAP009940-PA Anopheles gambiae str. PEST uc

AGAP010811 -8.53864 Ficolin - signalP detected s/imm Ficolin

AGAP002268 -8.515991 cell adhesion molecule Aedes aegypti - signalP detected extmat

AGAP009128 -8.5086975 Mitochondrial carrier protein - 3 predicted membrane helices met/energy membrane

AGAP003743 -8.453788 AGAP003743-PA Anopheles gambiae str. PEST uc

AGAP009786 -8.433315 Glycinamide ribonucleotide synthetase (GARS)/Aminoimidazole ribonucleotide synthetase (AIRS)

met/nuc

AGAP013109 -8.43283 vitellogenin 2 - signalP detected storage/

AGAP009493 -8.367952 Acetylcholine receptor - signalP detected - 4 predicted membrane helices st membrane

AGAP004170 -8.312678 hypothetical protein AND_11656 uc

AGAP009556 -8.310991 Ficolin - signalP detected s/imm Ficolin

AGAP005253 -8.270031 AGAP005253-PA Anopheles gambiae str. PEST uc

AGAP008739 -8.210671 BTB (POZ) domain containing 9 - cellular_component - biological_process - molecular_function - protein binding - cell adhesion

extmat

AGAP012571 -8.21023 hypothetical protein AaeL_AAEL008802 Aedes aegypti - signalP detected s/

AGAP001076 -8.209708 Cytochrome P450 CYP4/CYP19/CYP26 subfamilies detox/ox

AGAP008368 -8.197153 CD109 antigen - serine-type endopeptidase inhibitor - extracellular space - extracellular region - protein binding - plasma membrane - anchored to

s/protinh

AGAP010415 -8.163204 Trypsin-like serine protease pm/protease

AGAP002156 -8.153768 AGAP002156-PB Anopheles gambiae str. PEST - 7 predicted membrane helices st membrane

AGAP012328 -8.136521 clip-domain serine protease, Aedes aegypti pm/protease

AGAP011317 -8.104333 AGAP011317-PA Anopheles gambiae str. PEST uc

AGAP003251 -8.08562 Trypsin - signalP detected s/met/aa Trypsin

AGAP010530 -8.078346 Trypsin-like serine protease pm/protease

AGAP010197 -8.070226 SOCS box protein SSB-1, contains SPRY domain uc

AGAP009940 -8.058928 AGAP009940-PA Anopheles gambiae str. PEST uc

AGAP003474 -8.027518 Hypothetical secreted protein precursor - signalP detected s/

AGAP006909 -8.011718 serine protease inhibitor (AGAP006909-PA) Anopheles gambiae str. PEST - signalP detected

s/protinh

AGAP012352 -7.960533 ML domain - signalP detected s/imm ML

AGAP013348 -7.9539413 Hypothetical secreted protein precursor - signalP detected s/

AGAP000180 -7.942948 Phosphoribosylamidoimidazole-succinocarboxamide synthase met/nuc

AGAP010415 -7.940545 Trypsin-like serine protease pm/protease

AGAP011781 -7.8870783 Trypsin-like serine protease - signalP detected s/protease

AGAP012375 -7.8333817 Protein aurora borealis - activation of protein kinase - cytoplasm - nucleus st

AGAP006441 -7.8187323 GTP cyclohydrolase I met/int

AGAP008015 -7.813656 Nuclear envelope protein lamin, intermediate filament superfamily - 19 NetOglyc sites

nr

AGAP005548 -7.8042636 Alpha crystallins pm

AGAP009556 -7.8020353 Ficolin - signalP detected s/imm Ficolin

AGAP004731 -7.796418 secretory Phospholipase A2, Aedes aegypti - signalP detected s/met/lipd secretory

AGAP004286 -7.76769 dentin sialophosphoprotein - cellular response to cell-matrix adhesion - odontogenesis - odontogenesis of dentine-containing tooth - biomineral

extmat

AGAP004243 -7.7502785 AGAP004243-PA Anopheles gambiae str. PEST uc

AGAP011604 -7.7276607 Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines - fungal-type cell wall organization - fungal-type - signalP detected

extmat

AGAP011790 -7.72477 CLIP-domain serine protease subfamily A (AGAP011790-PB) Anopheles gambiae str. PEST - signalP detected

s/protease

AGAP005245 -7.7043424 Proteins containing BTB/POZ and Kelch , involved in regulatory/signal transduction processes

st

AGAP006781 -7.673663 Dentin sialophosphoprotein - multicellular organismal development - collagen binding - extracellular matrix structural constituent - biomineral

extmat

AGAP007455 -7.6704187 Membrane glycoprotein LIG-1 - signalP detected s/imm Membrane

AGAP012843 -7.664453 Trypsin-like serine protease pm/protease

AGAP009338 -7.642896 Anaphase promoting complex, Cdc20, Cdh1, and Ama1 subunits nr

AGAP009859 -7.6115007 Hypothetical secreted mucin - signalP detected s/mucin

AGAP004318 -7.606545 CLIP-domain serine protease subfamily C (AGAP004318-PA) Anopheles gambiae str. PEST - signalP detected

s/protease

AGAP003691 -7.5806236 serine protease Culex quinquefasciatus - signalP detected s/protease

AGAP013231 -7.549262 Carbon-nitrogen hydrolase met/aa

AGAP009682 -7.527192 AGAP009682-PA Anopheles gambiae str. PEST uc

AGAP002594 -7.4937434 Apolipoprotein D - lipid metabolic process - transporter - protein binding - lipid transporter - lipid binding - extracellular space - signalP detected

tr

AGAP008118 -7.4910283 Serine/threonine protein kinase st

AGAP008843 -7.4908824 Aquaporin (major intrinsic protein family) - 6 predicted membrane helices tr membrane

AGAP007711 -7.469472 Conserved plasma membrane protein - 2 predicted membrane helices uc/memb membrane

AGAP003878 -7.44739 carboxypeptidase N, polypeptide 2 - biological_process - molecular_function - cellular_component - protein binding - extracellular region - signalP detected

s/protease

AGAP005388 -7.4291964 si:ch211-199i15.4 - lipid binding - cytoplasmic vesicle - Golgi apparatus - membrane - endosome - transporter

tr

AGAP010548 -7.4062114 ZC101.2e CE18424 WBGene00006787 locus:unc-52 IG (immunoglobulin) superfamily (17 ), Low-density lipoprotein receptor domain class A (3 ), Laminin

st

AGAP001989 -7.399603 hyp37.3 secreted salivary gland protein - signalP detected s/

AGAP007647 -7.3673873 Dentin sialophosphoprotein - multicellular organismal development - collagen binding - extracellular matrix structural constituent - biomineral - 13 NetOglyc sites

extmat

AGAP008638 -7.364478 Histone H1.0 - nucleus - chromosome - nucleosome assembly - Golgi apparatus - nucleosome - DNA binding

nr

AGAP012352 -7.338928 ML domain - signalP detected s/imm ML

AGAP001624 -7.3380995 Vacuolar H+-ATPase V0 sector, accessory subunit S1 (Ac45) - signalP detected tr

AGAP012662 -7.3357873 Carbon-nitrogen hydrolase met/aa

AGAP003366 -7.3038874 Predicted dual-specificity phosphatase uc

AGAP013094 -7.29905 Fatty acyl-CoA elongase/Polyunsaturated fatty acid specific elongation enzyme - 7 predicted membrane helices

met/lipd membrane

AGAP006348 -7.287241 Membrane glycoprotein LIG-1 - signalP detected s/imm Membrane

AGAP003453 -7.2817645 Conserved plasma membrane protein - 2 predicted membrane helices - 15 NetOglyc sites

uc/memb membrane

AGAP004318 -7.2718387 CLIP-domain serine protease subfamily C (AGAP004318-PA) Anopheles gambiae str. PEST - signalP detected

s/protease

AGAP009656 -7.240997 AGAP009656-PA Anopheles gambiae str. PEST uc

AGAP009107 -7.2312436 Hypothetical secreted protein precursor - signalP detected s/

AGAP013221 -7.18723 Trypsin-like serine protease - signalP detected s/protease

AGAP010530 -7.184469 Trypsin-like serine protease pm/protease

AGAP010730 -7.1739097 CLIP-domain serine protease subfamily A (AGAP010731-PA) Anopheles gambiae str. PEST

pm/protease

AGAP000885 -7.171703 Puromycin-sensitive aminopeptidase - signalP detected s/met/aa Puromycin-sensitive

AGAP012107 -7.168085 Ubiquitin-protein ligase pm

AGAP012032 -7.1391463 ZC101.2e CE18424 WBGene00006787 locus:unc-52 IG (immunoglobulin) superfamily (17 ), Low-density lipoprotein receptor domain class A (3 ), Laminin

st

AGAP008141 -7.1362042 Argininosuccinate lyase met/aa

AGAP009670 -7.133555 serine protease inhibitor (AGAP009670-PB) Anopheles gambiae str. PEST - signalP detected

s/protinh

AGAP009670 -7.1150303 serine protease inhibitor (AGAP009670-PB) Anopheles gambiae str. PEST - signalP detected

s/protinh

AGAP013231 -7.1120067 Carbon-nitrogen hydrolase met/aa

AGAP000871 -7.0417953 C-type lectin domain family 4, member f - integral to membrane - membrane - endocytosis - sugar binding - binding - receptor - signalP detected

st

AGAP012985 -7.027253 rhodopsin receptor 3 (AGAP001163-PA) Anopheles gambiae str. PEST - 7 predicted membrane helices

st membrane

AGAP010715 -6.963588 Actin binding protein Anillin - 13 NetOglyc sites nr

AGAP012036 -6.9593387 Trypsin-like serine protease - signalP detected s/protease

AGAP010839 -6.9397626 AGAP010839-PA Anopheles gambiae str. PEST - 11 NetOglyc sites uc

AGAP005712 -6.920244 Aromatic amino acid hydroxylase met/aa

AGAP010909 -6.887632 Sequence-specific single-stranded-DNA-binding protein - 21 NetOglyc sites nr

AGAP002890 -6.879273 Lipid storage droplet-2 - microtubule associated complex - lipid metabolic process - regulation of transport - protein binding - lipid particle

cs

AGAP013215 -6.87672 Ring finger prot

AGAP013005 -6.858747 Hypothetical secreted mucin - signalP detected s/mucin

AGAP001076 -6.8455367 Cytochrome P450 CYP4/CYP19/CYP26 subfamilies detox/ox

AGAP012875 -6.841956 pupal-specific cuticular protein CP2c - signalP detected extmat

AGAP008694 -6.8341923 myosin, heavy chain 6, cardiac muscle, alpha - ventricular cardiac muscle tissue morphogenesis - atrial cardiac muscle tissue morphogenesis - cardiac

cs

AGAP003301 -6.827169 M-phase inducer phosphatase nr

AGAP011765 -6.806094 BPTI/Kunitz family of serine protease inhibitors - signalP detected s/protinh Kunitz

AGAP004318 -6.764558 CLIP-domain serine protease subfamily C (AGAP004318-PA) Anopheles gambiae str. PEST - signalP detected

s/protease

AGAP010531 -6.752919 Ficolin - signalP detected s/imm Ficolin

AGAP009670 -6.752358 serine protease inhibitor (AGAP009670-PB) Anopheles gambiae str. PEST - signalP detected

s/protinh

AGAP009556 -6.750566 Ficolin - signalP detected s/imm Ficolin

AGAP001826 -6.7200136 Retinoid- and fatty acid-binding glycoprotein - microtubule associated complex - receptor binding - endocytic vesicle - lipid particle - Wnt receptor

cs

AGAP003960 -6.7155704 Trypsin-like serine protease - signalP detected s/protease

AGAP006348 -6.7134986 Membrane glycoprotein LIG-1 - signalP detected s/imm Membrane

AGAP009609 -6.7105107 Homogentisate 1,2-dioxygenase met/aa

AGAP011622 -6.706374 Anaphase promoting complex, Cdc20, Cdh1, and Ama1 subunits pm

AGAP006348 -6.6994643 Membrane glycoprotein LIG-1 - signalP detected s/imm Membrane

AGAP012375 -6.68662 Protein aurora borealis - activation of protein kinase - cytoplasm - nucleus st

AGAP006348 -6.6788015 Membrane glycoprotein LIG-1 - signalP detected s/imm Membrane

AGAP006921 -6.6778965 GULP, engulfment adaptor PTB domain containing 1 - apoptosis - phagocytosis, engulfment - lipid transport - cytoplasm - protein binding

st/apoptosis

AGAP010730 -6.663543 CLIP-domain serine protease subfamily A (AGAP010731-PA) Anopheles gambiae str. PEST

pm/protease

AGAP006348 -6.6366982 Membrane glycoprotein LIG-1 - signalP detected s/imm Membrane

AGAP007123 -6.594686 Dimethylglycine dehydrogenase precursor met/aa

AGAP008061 -6.590083 Chitinase - signalP detected met/carb

AGAP003775 -6.5379777 AGAP003775-PA Anopheles gambiae str. PEST uc

AGAP010815 -6.470439 CD109 antigen - serine-type endopeptidase inhibitor - extracellular space - extracellular region - protein binding - plasma membrane - anchored to - signalP detected

s/protinh

AGAP011183 -6.465555 Hypothetical secreted protein precursor - signalP detected s/

AGAP000751 -6.4508996 Spindle assembly checkpoint protein nr

AGAP002192 -6.430813 Isocitrate dehydrogenase, gamma subunit met/aa

AGAP008444 -6.429029 Adult cuticle protein 1 - structural constituent of adult chitin-based cuticle - signalP detected

extmat

AGAP013184 -6.4253387 serine protease Culex quinquefasciatus - signalP detected s/protease

AGAP012107 -6.420297 Ubiquitin-protein ligase pm

AGAP007037 -6.4064107 Membrane glycoprotein LIG-1 - signalP detected s/imm Membrane

AGAP001687 -6.405923 RhoGAP domain-containing protein - signal transduction - Rac GTPase activator - regulation of Rac protein signal transduction - intracellular

st

AGAP004719 -6.4026375 Trypsin-like serine protease - signalP detected s/protease

AGAP009859 -6.3912554 Hypothetical secreted mucin - signalP detected s/mucin

AGAP000871 -6.3709145 C-type lectin domain family 4, member f - integral to membrane - membrane - endocytosis - sugar binding - binding - receptor - signalP detected

st

AGAP001116 -6.3231087 D-aspartate oxidase met/aa

AGAP000135 -6.2796903 AGAP000135-PA Anopheles gambiae str. PEST uc

AGAP004316 -6.261305 11.9 kDa salivary protein - signalP detected s/

AGAP003937 -6.257397 PDZ and LIM domain protein 7 - cell junction - cell differentiation - actin cytoskeleton - focal adhesion - ossification - receptor-mediated

extmat

AGAP011831 -6.257028 Uncharacterized conserved protein - 16 NetOglyc sites uc

AGAP005914 -6.2560816 Serine carboxypeptidase S28 - signalP detected s/met/aa Serine

AGAP007385 -6.2456713 AGAP007385-PA Anopheles gambiae str. PEST - signalP detected s/imm AGAP007385-PA

AGAP008694 -6.2401958 myosin, heavy chain 6, cardiac muscle, alpha - ventricular cardiac muscle tissue morphogenesis - atrial cardiac muscle tissue morphogenesis - cardiac

cs

AGAP000278 -6.234812 odorant binding protein (AGAP000278-PA) Anopheles gambiae str. PEST - signalP detected OBP

s/OBP

AGAP007315 -6.2314415 Conserved plasma membrane protein - signalP detected - 4 predicted membrane helices

uc/memb membrane

AGAP013503 -6.2185473 vitellogenin 2 - signalP detected storage/

AGAP011845 -6.2125406 Histone 2A nr

AGAP002925 -6.1829543 serine-type peptidase - signalP detected s/protease

AGAP008011 -6.176019 Conserved plasma membrane protein - signalP detected - 2 predicted membrane helices

uc/memb membrane

AGAP004239 -6.1758285 Polo-like serine/threonine protein kinase nr

AGAP004787 -6.173039 Acyl-CoA reductase - 2 predicted membrane helices met/lipd membrane

AGAP012154 -6.1518416 H+/oligopeptide symporter - 11 predicted membrane helices met/aa membrane

AGAP013348 -6.1483893 Hypothetical secreted protein precursor - signalP detected s/

AGAP008363 -6.1322546 Cytochrome b5 met/energy

AGAP008368 -6.113215 CD109 antigen - serine-type endopeptidase inhibitor - extracellular space - extracellular region - protein binding - plasma membrane - anchored to

s/protinh

AGAP010815 -6.1077843 CD109 antigen - serine-type endopeptidase inhibitor - extracellular space - extracellular region - protein binding - plasma membrane - anchored to - signalP detected

s/protinh

AGAP003027 -6.1049356 Neurogenic locus notch homolog protein 3 - calcium ion binding - nucleus - tissue regeneration - regulation of transcription, DNA-dependent - - signalP detected

tm

AGAP007817 -6.094748 Nuclear protein COP1 st

AGAP010530 -6.0902767 Trypsin-like serine protease pm/protease

AGAP004719 -6.084873 Trypsin-like serine protease - signalP detected s/protease

AGAP002075 -6.0764704 Dual specificity; serine/threonine and tyrosine kinase nr

AGAP007043 -6.0735397 Trypsin-like serine protease pm/protease

AGAP012404 -6.053333 Alanine-glyoxylate aminotransferase AGT2 met/aa

AGAP000211 -6.0492787 pancreatic triacylglycerol lipase Culex quinquefasciatus met/lipd

AGAP005620 -6.0470247 Hypothetical secreted protein precursor - signalP detected s/

AGAP003868 -6.041438 AGAP003868-PA Anopheles gambiae str. PEST uc

AGAP010928 -6.031865 TPR repeat-containing protein uc

AGAP009217 -6.0131044 CLIP-domain serine protease subfamily B (AGAP009217-PA) Anopheles gambiae str. PEST - signalP detected

s/protease

AGAP001453 -6.0076103 AGAP001453-PA Anopheles gambiae str. PEST uc

AGAP006910 -5.974545 serine protease inhibitor (AGAP006910-PA) Anopheles gambiae str. PEST - signalP detected

s/protinh

AGAP003290 -5.9387946 Hypothetical secreted protein precursor - signalP detected s/

AGAP006823 -5.9124866 AGAP006823-PA Anopheles gambiae str. PEST uc

AGAP001076 -5.9117618 Cytochrome P450 CYP4/CYP19/CYP26 subfamilies detox/ox

AGAP008335 -5.858872 Synaptic vesicle transporter SVOP - signalP detected - 11 predicted membrane helices

tr membrane

AGAP009670 -5.826812 serine protease inhibitor (AGAP009670-PB) Anopheles gambiae str. PEST - s/protinh

signalP detectedAGAP008468 -5.826004 Animal-type fatty acid synthase met/lipd

AGAP009107 -5.811236 Hypothetical secreted protein precursor - signalP detected s/

AGAP002478 -5.810413 Cyclin B nr

AGAP003245 -5.758467 easter - zymogen activation - proteolysis - peptidase - defense response - serine-type peptidase - extracellular region - signalP detected

s/protease

AGAP007791 -5.7518363 C17E4.9 CE08258 WBGene00007646 locus:nkb-1 sodium\/potassium transporting ATPase beta chain status:Confirmed UniProt:Q93235 protein_id:CAB02752.1 - Membrane anchor detected

tr membrAnchor

AGAP009261 -5.749842 cAMP-regulated guanine nucleotide exchange factor - 16 NetOglyc sites st

AGAP009978 -5.7450514 Animal haem peroxidase - 6 predicted membrane helices detox/ox membrane

AGAP009871 -5.7315598 cuticular protein 75, RR-1 family (AGAP009871-PA) Anopheles gambiae str. PEST - signalP detected

extmat

AGAP011789 -5.7110405 CLIP-domain serine protease subfamily A (AGAP011789-PA) Anopheles gambiae str. PEST - signalP detected

s/protease

AGAP009670 -5.658962 serine protease inhibitor (AGAP009670-PB) Anopheles gambiae str. PEST - signalP detected

s/protinh

AGAP011351 -5.633176 Uncharacterized conserved protein, contains DENN and RUN st

AGAP010830 -5.6295433 CD109 antigen - serine-type endopeptidase inhibitor - extracellular space - extracellular region - protein binding - plasma membrane - anchored to - signalP detected

s/protinh

AGAP000806 -5.60776 Ficolin - signalP detected s/imm Ficolin

AGAP003591 -5.5903606 Leucine-rich repeat (LRR) protein, contains calponin homology domain cs

AGAP012982 -5.5815864 rhodopsin receptor 3 (AGAP001163-PA) Anopheles gambiae str. PEST - 7 predicted membrane helices

st membrane

AGAP006480 -5.558303 Conserved plasma membrane protein - signalP detected - 2 predicted membrane helices

uc/memb membrane

AGAP004855 -5.5460277 CLIP-domain serine protease subfamily B (AGAP004855-PA) Anopheles gambiae str. PEST - signalP detected

s/protease

AGAP005223 -5.539915 Apolipoprotein D/Lipocalin - signalP detected extmat

AGAP007045 -5.5297275 carboxypeptidase N subunit 2 Culex quinquefasciatus - signalP detected s/protease

AGAP003245 -5.5181375 easter - zymogen activation - proteolysis - peptidase - defense response - serine-type peptidase - extracellular region - signalP detected

s/protease

AGAP003691 -5.515473 serine protease Culex quinquefasciatus - signalP detected s/protease

AGAP000204 -5.5012517 Hypothetical secreted protein precursor - signalP detected s/

AGAP003868 -5.490301 AGAP003868-PA Anopheles gambiae str. PEST uc

AGAP000159 -5.4716244 Kinesin-like protein cs

AGAP006186 -5.468997 endoplasmic reticulum-type (ACA6) (ECA3), nearly identical to SP:Q9SY55 Calcium-transporting ATPase 3, endoplasmic reticulum-type (EC 3.6.3.8) - 9 predicted membrane helices

tr membrane

AGAP003083 -5.4569826 Triglyceride lipase-cholesterol esterase - signalP detected s/met/lipd Triglyceride

AGAP002514 -5.41846 AGAP002514-PA Anopheles gambiae str. PEST - 19 NetOglyc sites uc

AGAP001323 -5.4104185 AGAP001323-PA Anopheles gambiae str. PEST uc

AGAP006263 -5.403047 Arrestin st

AGAP011351 -5.392219 Uncharacterized conserved protein, contains DENN and RUN st

AGAP006723 -5.3844566 Acetylcholinesterase/Butyrylcholinesterase st

AGAP010812 -5.382801 CD109 antigen - serine-type endopeptidase inhibitor - extracellular space - extracellular region - protein binding - plasma membrane - anchored to

s/protinh

AGAP003550 -5.3735194 futsch - olfactory learning - neurofilament cytoskeleton organization - negative regulation of neuron apoptosis - axon cargo transport -

st/apoptosis

AGAP010178 -5.3682613 Hypothetical secreted protein precursor - signalP detected s/

AGAP008368 -5.360329 CD109 antigen - serine-type endopeptidase inhibitor - extracellular space - extracellular region - protein binding - plasma membrane - anchored to

s/protinh

AGAP006781 -5.349425 Dentin sialophosphoprotein - multicellular organismal development - collagen binding - extracellular matrix structural constituent - biomineral

extmat

AGAP002830 -5.344905 C1-tetrahydrofolate synthase met/int

AGAP013442 -5.3006697 CLIP-domain serine protease subfamily B (AGAP003058-PA) Anopheles gambiae str. PEST - signalP detected

s/protease

AGAP011780 -5.2937236 CLIP-domain serine protease subfamily A (AGAP011780-PA) Anopheles gambiae str. PEST - signalP detected

s/protease

AGAP002721 -5.2750063 Tryptophan 2,3-dioxygenase met/aa

AGAP005712 -5.266665 Aromatic amino acid hydroxylase met/aa

AGAP007500 -5.2622356 Lachesin - plasma membrane - morphogenesis of embryonic epithelium - septate junction - homophilic cell adhesion - maintenance of epithelial - signalP detected - 2 predicted membrane helices

extmat membrane

AGAP005625 -5.254981 Trypsin - signalP detected s/met/aa Trypsin

AGAP007122 -5.246978 Alpha tubulin cs

AGAP005763 -5.2361465 Tyrosine kinases st

AGAP012599 -5.216844 Nucleotide excision repair complex XPC-HR23B, subunit XPC/DPB11 nr

AGAP012982 -5.2154183 rhodopsin receptor 3 (AGAP001163-PA) Anopheles gambiae str. PEST - 7 predicted membrane helices

st membrane

AGAP002890 -5.209918 Lipid storage droplet-2 - microtubule associated complex - lipid metabolic process - regulation of transport - protein binding - lipid particle

cs

AGAP005125 -5.19475 Predicted E3 ubiquitin ligase pm

AGAP005456 -5.1774406 cuticular protein 15, RR-1 family (AGAP005456-PA) Anopheles gambiae str. PEST - signalP detected

extmat

AGAP008810 -5.1621957 Retinoid- and fatty acid-binding glycoprotein - microtubule associated complex - receptor binding - endocytic vesicle - lipid particle - Wnt receptor

cs

AGAP011070 -5.1350446 Ras guanine nucleotide exchange factor - regulation of small GTPase mediated signal transduction - sexual reproduction - positive regulation of

cs

AGAP007473 -5.124663 FK506-binding protein 1 - microtubule associated complex - negative regulation of autophagy - negative regulation of macroautophagy - peptidyl-prolyl

cs

AGAP013180 -5.123962 DNA repair protein RHP57 nr

AGAP003418 -5.1088243 Fatty acid desaturase - 4 predicted membrane helices met/lipd membrane

AGAP012900 -5.1036253 Papain family cysteine protease pm/protease

AGAP012352 -5.0880814 ML domain - signalP detected s/imm ML

AGAP003058 -5.0712533 CLIP-domain serine protease subfamily B (AGAP003058-PA) Anopheles gambiae str. PEST - signalP detected

s/protease

AGAP010547 -5.0707364 Trypsin-like serine protease pm/protease

AGAP001356 -5.0593014 Acetylcholinesterase/Butyrylcholinesterase - signalP detected st

AGAP004408 -5.043615 DNA replication licensing factor, MCM5 component nr

AGAP003248 -5.0299416 CLIP-domain serine protease subfamily B (AGAP003249-PA) Anopheles gambiae str. PEST - signalP detected

s/protease

AGAP008012 -5.019165 Hypothetical secreted mucin - signalP detected s/mucin

AGAP012017 -5.0162373 AGAP012017-PA Anopheles gambiae str. PEST uc

AGAP013442 -5.002009 CLIP-domain serine protease subfamily B (AGAP003058-PA) Anopheles gambiae str. PEST - signalP detected

s/protease

AGAP008468 -4.962826 Animal-type fatty acid synthase met/lipd

AGAP005612 -4.9318357 Hypothetical secreted protein precursor - signalP detected s/

AGAP010731 -4.930946 CLIP-domain serine protease subfamily A (AGAP010731-PA) Anopheles gambiae str. PEST - signalP detected

s/protease

AGAP002913 -4.907524 Conserved secreted protein precursor - signalP detected s/ucs

AGAP001582 -4.8991823 Conserved plasma membrane protein - 4 predicted membrane helices uc/memb membrane

AGAP011845 -4.8411317 Histone 2A nr

AGAP002783 -4.8281407 UDP-glucuronosyl and UDP-glucosyl transferase - signalP detected - 2 predicted membrane helices

met/carb membrane

AGAP011780 -4.8150315 CLIP-domain serine protease subfamily A (AGAP011780-PA) Anopheles gambiae str. PEST - signalP detected

s/protease

AGAP011454 -4.8096824 AGAP011454-PA Anopheles gambiae str. PEST uc

AGAP003702 -4.805796 integral to membrane - zinc ion binding - metallopeptidase - calcium ion binding - proteolysis - metalloendopeptidase - signalP detected

s/protease

AGAP001281 -4.791852 inwardly rectifying k+ channel, Aedes aegypti - 2 predicted membrane helices tr membrane

AGAP013147 -4.791689 Centrosome-associated protein CEP250 - microtubule organizing center - cytoskeleton - protein complex - protein localization - perinuclear region of - signalP detected

cs

AGAP013186 -4.77996 Protein phosphatase 1, regulatory subunit, - signalP detected s/st Protein

AGAP010077 -4.7539873 Cytochrome P450 CYP2 subfamily detox/ox

AGAP000573 -4.7449102 CLIP-domain serine protease subfamily C (AGAP000573-PA) Anopheles gambiae str. PEST - signalP detected

s/protease

AGAP006702 -4.7332525 Predicted RNA-binding protein involved in translational regulation - 18 NetOglyc sites

ps

AGAP007851 -4.7253127 Hypothetical secreted protein precursor - signalP detected s/

AGAP005009 -4.718783 Pyrroline-5-carboxylate reductase met/aa

AGAP003740 -4.7132144 AGAP003740-PA Anopheles gambiae str. PEST uc

AGAP008141 -4.7026796 Argininosuccinate lyase met/aa

AGAP004243 -4.7018056 AGAP004243-PA Anopheles gambiae str. PEST uc

AGAP003691 -4.6545496 serine protease Culex quinquefasciatus - signalP detected s/protease

AGAP003583 -4.635225 Sorbitol dehydrogenase detox

AGAP011791 -4.6325154 CLIP-domain serine protease subfamily A (AGAP011791-PA) Anopheles gambiae str. PEST - signalP detected

s/protease

AGAP007609 -4.629386 Hypothetical secreted protein precursor - signalP detected s/

AGAP005841 -4.60955 AGAP005841-PA Anopheles gambiae str. PEST uc

AGAP009110 -4.5884023 Hypothetical secreted mucin - signalP detected s/mucin

AGAP002039 -4.571093 Conserved plasma membrane protein - signalP detected - 4 predicted membrane helices

uc/memb membrane

AGAP000994 -4.570581 lysosomal Pro-X carboxypeptidase Culex quinquefasciatus - signalP detected s/met/aa lysosomal

AGAP013290 -4.562265 Conserved secreted protein precursor - signalP detected s/ucs

AGAP013149 -4.5596013 rhodopsin receptor 1 (AGAP001178-PA) Anopheles gambiae str. PEST - 7 predicted membrane helices

st membrane

AGAP000750 -4.552252 Haemolymph juvenile hormone binding protein - signalP detected s/

AGAP006835 -4.530045 Mastermind-like protein 2 - nuclear speck - regulation of transcription - Notch signaling pathway - transcription coactivator - nucleus - positive - signalP detected

tm

AGAP001376 -4.5236187 serine protease inhibitor (AGAP001376-PA) Anopheles gambiae str. PEST - signalP detected

s/protinh

AGAP010812 -4.5229406 CD109 antigen - serine-type endopeptidase inhibitor - extracellular space - extracellular region - protein binding - plasma membrane - anchored to

s/protinh

AGAP007407 -4.507594 Macrophage mannose receptor 1 - mannose binding - integral to plasma membrane - plasma membrane - receptor - sugar binding - receptor-mediated - signalP detected

st

AGAP005611 -4.4955497 Hypothetical secreted protein precursor - signalP detected s/

AGAP011604 -4.4827213 Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines - fungal-type cell wall organization - fungal-type - signalP detected

extmat

AGAP000675 -4.475289 AGAP000675-PA Anopheles gambiae str. PEST uc

AGAP010018 -4.463968 Uncharacterized conserved protein uc

AGAP011324 -4.4606876 Glycosyltransferase - signalP detected extmat

AGAP001506 -4.460502 G protein beta-subunit 76C - plasma membrane - cytoplasm - activation of phospholipase C - G-protein coupled receptor protein signaling pathway -

st

AGAP011621 -4.448377 WD40-repeat-containing subunit of the 18S rRNA processing complex tm

AGAP002632 -4.448369 Hypothetical secreted protein precursor - signalP detected s/

AGAP006921 -4.442514 GULP, engulfment adaptor PTB domain containing 1 - apoptosis - phagocytosis, engulfment - lipid transport - cytoplasm - protein binding

st/apoptosis

AGAP007264 -4.437264 Fatty acyl-CoA elongase/Polyunsaturated fatty acid specific elongation enzyme - 7 predicted membrane helices

met/lipd membrane

AGAP012952 -4.4345303 AGAP004243-PA Anopheles gambiae str. PEST uc

AGAP005625 -4.4220514 Trypsin - signalP detected s/met/aa Trypsin

AGAP001423 -4.4173813 AICAR transformylase/IMP cyclohydrolase/methylglyoxal synthase met/nuc

AGAP008060 -4.4148808 Chitinase - signalP detected met/carb

AGAP007413 -4.393066 Microcephalin - intracellular - microtubule organizing center - cytoskeleton - cytoplasm - 18 NetOglyc sites

cs

AGAP004008 -4.378837 Catalytic domain of Protein Kinases - 15 NetOglyc sites st

AGAP004585 -4.3736067 Translin-associated protein X uc

AGAP004018 -4.3697762 Syntrophins (type gamma) - 15 NetOglyc sites extmat

AGAP006910 -4.3313155 serine protease inhibitor (AGAP006910-PA) Anopheles gambiae str. PEST - signalP detected

s/protinh

AGAP005407 -4.313365 AGAP005407-PA Anopheles gambiae str. PEST uc

AGAP001511 -4.312197 Transcription regulator dachshund, contains SKI/SNO domain - signalP detected

tm

AGAP001076 -4.309653 Cytochrome P450 CYP4/CYP19/CYP26 subfamilies detox/ox

AGAP009459 -4.304614 Cyclin-dependent kinase CDK5 pe

AGAP001993 -4.3025136 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1

tm

AGAP011791 -4.28449 CLIP-domain serine protease subfamily A (AGAP011791-PA) Anopheles gambiae str. PEST - signalP detected

s/protease

AGAP001010 -4.279555 Chondroitin synthase 1 - signalP detected met/carb

AGAP004630 -4.272563 Conserved plasma membrane protein - signalP detected - 4 predicted membrane helices

uc/memb membrane

AGAP009364 -4.27037 Clavesin-1 - transporter - trans-Golgi network - phosphatidylinositol-3,5-bisphosphate binding - endosome - early endosome membrane - lysosome

tr

AGAP005783 -4.2679453 anillin, actin binding protein - cytokinesis - actin binding - actin cytoskeleton - actomyosin contractile ring - protein binding - cell division

cs

AGAP008165 -4.2670493 Phosphatidylinositol transfer protein SEC14 met/lipd

AGAP000751 -4.2593727 Spindle assembly checkpoint protein nr

AGAP010833 -4.24761 CLIP-domain serine protease subfamily B (AGAP010833-PA) Anopheles gambiae str. PEST - signalP detected

s/protease

AGAP001280 -4.2439427 inwardly rectifying k+ channel, Aedes aegypti - 3 predicted membrane helices - Membrane anchor detected

tr membrane membrAnchor

AGAP000628 -4.2392383 Transcriptional coactivator p100 tm

AGAP013252 -4.238406 Trypsin-like serine protease - signalP detected s/protease

AGAP000133 -4.22735 AGAP000133-PA Anopheles gambiae str. PEST uc

AGAP001980 -4.2209134 MFS-type transporter C6orf192 - transmembrane transport - integral to membrane - membrane - signalP detected - 12 predicted membrane helices

tr membrane

AGAP010530 -4.220141 Trypsin-like serine protease pm/protease

AGAP011088 -4.1777434 Transcriptional coactivator p100 tm

AGAP004787 -4.174392 Acyl-CoA reductase - 2 predicted membrane helices met/lipd membrane

AGAP009849 -4.1680865 Trypsin-like serine protease pm/protease

AGAP010703 -4.146112 Uncharacterized conserved protein nr

AGAP010725 -4.14461 Sulfate/bicarbonate/oxalate exchanger SAT-1 - 12 predicted membrane helices

tr membrane

AGAP004587 -4.1435013 Conserved plasma membrane protein - signalP detected - 4 predicted membrane helices

uc/memb membrane

AGAP013260 -4.138492 Chitinase - signalP detected met/carb

AGAP000871 -4.138242 C-type lectin domain family 4, member f - integral to membrane - membrane - endocytosis - sugar binding - binding - receptor - signalP detected

st

AGAP003620 -4.1370697 AGAP003620-PA Anopheles gambiae str. PEST uc

AGAP007708 -4.1228857 AGAP007708-PA Anopheles gambiae str. PEST uc

AGAP009215 -4.114768 CLIP-domain serine protease subfamily B (AGAP009214-PA) Anopheles gambiae str. PEST - signalP detected

s/protease

AGAP001657 -4.1105704 Larval serum protein 2 - lipid particle - transport - oxygen transporter - extracellular region - nutrient reservoir - larval serum protein complex - signalP detected

tr

AGAP005800 -4.1102266 DNA replication licensing factor, MCM7 component nr

AGAP006165 -4.109052 SNF2 family DNA-dependent ATPase - 11 NetOglyc sites nr

AGAP010547 -4.1057324 Trypsin-like serine protease pm/protease

AGAP005986 -4.08931 Acyl-CoA reductase met/lipd

AGAP006702 -4.0863147 Predicted RNA-binding protein involved in translational regulation - 18 NetOglyc sites

ps

AGAP000183 -4.075528 AGAP000183-PA Anopheles gambiae str. PEST - 11 NetOglyc sites uc

AGAP000650 -4.0750527 Ribonuclease P 40kDa met/nuc

AGAP004008 -4.0702124 Catalytic domain of Protein Kinases - 15 NetOglyc sites st

AGAP003743 -4.0646152 AGAP003743-PA Anopheles gambiae str. PEST uc

AGAP001687 -4.0479946 RhoGAP domain-containing protein - signal transduction - Rac GTPase activator - regulation of Rac protein signal transduction - intracellular

st

AGAP012307 -4.0381327 BPTI/Kunitz family of serine protease inhibitors - signalP detected s/protinh Kunitz

AGAP005763 -4.0268965 Tyrosine kinases st

AGAP012034 -4.026375 Trypsin-like serine protease - signalP detected s/protease

AGAP001065 -4.0234694 Glycine/serine hydroxymethyltransferase met/aa

AGAP000680 -4.0208297 AGAP000680-PA Anopheles gambiae str. PEST uc

AGAP009844 -4.020639 Trypsin - signalP detected s/met/aa Trypsin

AGAP004572 -4.0154552 Fatty acid desaturase - 4 predicted membrane helices met/lipd membrane

AGAP008245 -4.0030355 Apx/Shroom domain ASD2 - 21 NetOglyc sites cs

AGAP003190 -4.0004725 Mismatch repair ATPase MSH6 (MutS family) nr

AGAP001135 -3.998984 DNA replication licensing factor, MCM3 component nr

AGAP004585 -3.9850602 Translin-associated protein X uc

AGAP003197 -3.9832606 Fatty acyl-CoA elongase/Polyunsaturated fatty acid specific elongation enzyme - 7 predicted membrane helices

met/lipd membrane

AGAP000011 -3.9818213 Branched chain aminotransferase BCAT1, pyridoxal phosphate enzymes type IV superfamily

met/aa

AGAP005510 -3.977417 Oxysterol-binding protein st

AGAP003025 -3.9679787 60S acidic ribosomal protein P2 Aedes aegypti - signalP detected ps

AGAP007706 -3.9391284 Kinesin-like protein cs

AGAP003205 -3.9364798 Monocarboxylate transporter - 12 predicted membrane helices tr membrane

AGAP000186 -3.9299753 AGAP000186-PA Anopheles gambiae str. PEST uc

AGAP004957 -3.9229608 Origin recognition complex, subunit 1, nr

AGAP004639 -3.9226594 clip-domain serine protease Culex quinquefasciatus - signalP detected s/protease

AGAP011237 -3.921481 AGAP011237-PA Anopheles gambiae str. PEST uc

AGAP000680 -3.915638 AGAP000680-PA Anopheles gambiae str. PEST uc

AGAP002075 -3.9105582 Dual specificity; serine/threonine and tyrosine kinase nr

AGAP008807 -3.908144 Predicted lipoprotein met/lipd

AGAP008783 -3.9011116 Arginase met/aa

AGAP009978 -3.885895 Animal haem peroxidase - 6 predicted membrane helices detox/ox membrane

AGAP012037 -3.8849397 Trypsin-like serine protease - signalP detected s/protease

AGAP011347 -3.839343 Sulfatase - signalP detected detox

AGAP004500 -3.8319676 Protein predicted to be involved in spindle matrix formation, contains DM13, DoH, and DOMON - signalP detected

nr

AGAP011361 -3.8316252 Checkpoint 9-1-1 complex, HUS1 component met/energy

AGAP013038 -3.817554 S-M checkpoint control protein CID1 - signalP detected nr

AGAP007049 -3.809087 Hypothetical secreted protein precursor - signalP detected s/

AGAP005732 -3.8005106 AGAP005732-PA Anopheles gambiae str. PEST uc

AGAP013027 -3.781876 Toll-like receptor (AGAP010669-PA) Anopheles gambiae str. PEST - signalP detected

s/imm Toll-like

AGAP006911 -3.7708104 serine protease inhibitor (AGAP006911-PA) Anopheles gambiae str. PEST - signalP detected

s/protinh

AGAP013215 -3.7589693 Ring finger prot

AGAP005244 -3.7568393 bab2 - protein binding - polytene chromosome chromocenter - polytene chromosome - regulation of transcription - transcription factor - DNA binding - 14 NetOglyc sites

tf

AGAP001061 -3.7502913 Espin - parallel actin filament bundle assembly - locomotory behavior - stereocilium - brush border - actin cytoskeleton - sensory perception of sound

cs

AGAP007312 -3.7495124 Conserved plasma membrane protein - 4 predicted membrane helices - Membrane anchor detected

uc/memb membrane membrAnchor

AGAP010406 -3.7410064 Origin recognition complex, subunit 3 nr

AGAP007964 -3.737649 AGAP007964-PA Anopheles gambiae str. PEST - 15 NetOglyc sites uc

AGAP011789 -3.7344427 CLIP-domain serine protease subfamily A (AGAP011789-PA) Anopheles gambiae str. PEST - signalP detected

s/protease

AGAP007641 -3.730762 AGAP007641-PA Anopheles gambiae str. PEST uc

AGAP001731 -3.7226894 Zn-finger protein - 45 NetOglyc sites uc

AGAP001899 -3.7047563 Animal-type fatty acid synthase met/lipd

AGAP005459 -3.700054 cuticular protein 16, RR-1 family (AGAP005459-PA) Anopheles gambiae str. PEST - signalP detected

extmat

AGAP008127 -3.6918898 Protein tyrosine phosphatase st

AGAP000005 -3.6878796 Dorsal switch protein 1 - negative regulation of antimicrobial humoral response - leg disc development - DNA bending - chromatin remodeling -

imm

AGAP004203 -3.6870105 Lipoprotein amino terminal region - signalP detected storage/

AGAP011940 -3.6813245 Acid sphingomyelinase and PHM5 phosphate metabolism protein met/lipd

AGAP006762 -3.680155 Diacylglycerol kinase met/lipd

AGAP005363 -3.6732829 AGAP005363-PA Anopheles gambiae str. PEST uc

AGAP010234 -3.6693327 Microsomal triglyceride transfer protein - signalP detected s/met/lipd Microsomal

AGAP009034 -3.6649144 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily st

AGAP010676 -3.6535964 Nostrin - nucleus - plasma membrane - endocytosis - transcription repressor - cytoplasm - cytoplasmic membrane-bounded vesicle

tf

AGAP000877 -3.6491263 Cytochrome P450 CYP4/CYP19/CYP26 subfamilies detox/ox

AGAP005625 -3.6364906 Trypsin - signalP detected s/met/aa Trypsin

AGAP002248 -3.6262505 Kinesin (KAR3 subfamily) cs

AGAP012952 -3.6224027 AGAP004243-PA Anopheles gambiae str. PEST uc

AGAP004678 -3.6217766 Uncharacterized conserved protein uc

AGAP006192 -3.6196806 Trypsin-like serine protease - signalP detected s/protease

AGAP013476 -3.6055598 RNA polymerase II, large subunit - 57 NetOglyc sites tm

AGAP002741 -3.6010618 Histone H3 (Lys4) methyltransferase complex, subunit SET1 - 29 NetOglyc sites

nr

AGAP000907 -3.6002283 Acyl-CoA synthetase met/lipd

AGAP010219 -3.5951054 DNA replication licensing factor, MCM6 component nr

AGAP007043 -3.594892 Trypsin-like serine protease pm/protease

AGAP004239 -3.5759346 Polo-like serine/threonine protein kinase nr

AGAP013147 -3.562314 Centrosome-associated protein CEP250 - microtubule organizing center - cytoskeleton - protein complex - protein localization - perinuclear region of -

cs

signalP detectedAGAP003051 -3.5607817 Fatty acid desaturase - 4 predicted membrane helices met/lipd

membraneAGAP001053 -3.5500274 Troponin I cs

AGAP007045 -3.533916 carboxypeptidase N subunit 2 Culex quinquefasciatus - signalP detected s/protease

AGAP007407 -3.524613 Macrophage mannose receptor 1 - mannose binding - integral to plasma membrane - plasma membrane - receptor - sugar binding - receptor-mediated - signalP detected

st

AGAP008654 -3.5220942 KOG1366, KOG1366, Alpha-macroglobulin Posttranslational modification, protein turnover, chaperones

pm

AGAP002154 -3.5186372 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily st

AGAP009977 -3.4944885 Conserved plasma membrane protein - 2 predicted membrane helices - Membrane anchor detected

uc/memb membrane membrAnchor

AGAP009034 -3.4889395 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily st

AGAP004579 -3.478467 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, kinase subunit CDK7

nr

AGAP010220 -3.4744668 DNA polymerase delta processivity factor (proliferating cell nuclear antigen) nr

AGAP004719 -3.4727612 Trypsin-like serine protease - signalP detected s/protease

AGAP010673 -3.4717495 enabled - compound eye development - actin cytoskeleton organization - border follicle cell migration - cytoplasmic transport, nurse cell to oocyte - - 17 NetOglyc sites

cs

AGAP008364 -3.4684544 CD109 antigen - serine-type endopeptidase inhibitor - extracellular space - extracellular region - protein binding - plasma membrane - anchored to - signalP detected

s/protinh

AGAP004678 -3.4653387 Uncharacterized conserved protein uc

AGAP003937 -3.4499428 PDZ and LIM domain protein 7 - cell junction - cell differentiation - actin cytoskeleton - focal adhesion - ossification - receptor-mediated

extmat

AGAP003261 -3.4457047 Vesicle coat complex COPII, subunit SEC31 - 249 NetOglyc sites pe

AGAP000223 -3.4452305 Coeffector of mDia Rho GTPase, regulates actin polymerization and cell adhesion turnover

st

AGAP011507 -3.4451468 Acetylcholinesterase/Butyrylcholinesterase st

AGAP010645 -3.4435997 Hypothetical secreted protein precursor - signalP detected s/

AGAP012197 -3.4405599 Histones H3 and H4 nr

AGAP012928 -3.4393768 capicua homolog (Drosophila) - DNA binding - transcription - nucleus - regulation of transcription - 13 NetOglyc sites

tm

AGAP007497 -3.4303508 Copper/zinc superoxide dismutase detox/ox

AGAP003245 -3.4225228 easter - zymogen activation - proteolysis - peptidase - defense response - serine-type peptidase - extracellular region - signalP detected

s/protease

AGAP010219 -3.420355 DNA replication licensing factor, MCM6 component nr

AGAP005176 -3.4182186 Pre-initiation complex, subunit CDC6, AAA+ superfamily ATPase nr

AGAP001587 -3.415386 Vacuolar H+-ATPase V0 sector, subunit a - 6 predicted membrane helices tr membrane

AGAP010582 -3.4079208 Lipid exporter ABCA1 - 7 predicted membrane helices met/lipd membrane

AGAP007775 -3.4035335 DNA helicase PIF1/RRM3 nr

AGAP002429 -3.4013553 Cytochrome P450 CYP11/CYP12/CYP24/CYP27 subfamilies detox/ox

AGAP003187 -3.3869393 Protein tyrosine phosphatase - signalP detected - 2 predicted membrane helices

st membrane

AGAP005325 -3.383719 Spermidine synthase met/aa

AGAP010585 -3.383215 AGAP010585-PA Anopheles gambiae str. PEST - 19 NetOglyc sites uc

AGAP010048 -3.3629477 Predicted transporter - 11 predicted membrane helices tr membrane

AGAP010495 -3.352227 Alternative splicing factor ASF/SF2 (RRM superfamily) tm

AGAP004846 -3.3507502 Plasma membrane glycoprotein CD36 - signalP detected - 2 predicted membrane helices

st membrane

AGAP004719 -3.3445635 Trypsin-like serine protease - signalP detected s/protease

AGAP010519 -3.344431 Kinesin-like protein cs

AGAP011694 -3.3436737 Conserved plasma membrane protein - 7 predicted membrane helices uc/memb membrane

AGAP010887 -3.340675 cuticular protein 113, RR-1 family (AGAP010887-PA) Anopheles gambiae str. PEST - signalP detected

extmat

AGAP007407 -3.3316333 Macrophage mannose receptor 1 - mannose binding - integral to plasma membrane - plasma membrane - receptor - sugar binding - receptor-mediated - signalP detected

st

AGAP006548 -3.330533 Glycine cleavage system H protein (lipoate-binding) - signalP detected s/met/aa Glycine

AGAP008469 -3.3277276 Myosin-13 - myosin filament - actin binding - microfilament motor - protein binding - nucleotide binding - myofibril

cs

AGAP003190 -3.3233283 Mismatch repair ATPase MSH6 (MutS family) nr

AGAP009526 -3.3219116 Cytochrome c oxidase subunit VIIa - Membrane anchor detected met/energy membrAnchor

AGAP008948 -3.3173985 Serine/Threonine protein kinases st

AGAP004317 -3.315588 CLIP-domain serine protease subfamily C (AGAP004317-PA) Anopheles gambiae str. PEST - signalP detected

s/protease

AGAP002270 -3.3069537 CLIP-domain serine protease subfamily B (AGAP002270-PA) Anopheles gambiae str. PEST - signalP detected

s/protease

AGAP003239 -3.3060682 AGAP003239-PA Anopheles gambiae str. PEST uc

AGAP008364 -3.305682 CD109 antigen - serine-type endopeptidase inhibitor - extracellular space - extracellular region - protein binding - plasma membrane - anchored to - signalP detected

s/protinh

AGAP010123 -3.286624 cuticular protein 131, RR-2 family (AGAP010123-PA) Anopheles gambiae str. PEST - signalP detected

extmat

AGAP010812 -3.2795298 CD109 antigen - serine-type endopeptidase inhibitor - extracellular space - extracellular region - protein binding - plasma membrane - anchored to

s/protinh

AGAP004408 -3.2792833 DNA replication licensing factor, MCM5 component nr

AGAP005716 -3.2767453 Plasma membrane glycoprotein CD36 - 2 predicted membrane helices st membrane

AGAP011547 -3.2752242 AGAP011547-PA Anopheles gambiae str. PEST uc

AGAP012537 -3.2744005 NEM-sensitive fusion protein 2 - ATP binding - nucleoside-triphosphatase - regulation of synaptic growth at neuromuscular junction - neuromuscular

pe

AGAP008467 -3.2710078 Sodium-neurotransmitter symporter - 12 predicted membrane helices st membrane

AGAP004719 -3.2702377 Trypsin-like serine protease - signalP detected s/protease

AGAP005611 -3.2676456 Hypothetical secreted protein precursor - signalP detected s/

AGAP008364 -3.2594073 CD109 antigen - serine-type endopeptidase inhibitor - extracellular space - extracellular region - protein binding - plasma membrane - anchored to - signalP detected

s/protinh

AGAP002429 -3.253298 Cytochrome P450 CYP11/CYP12/CYP24/CYP27 subfamilies detox/ox

AGAP003571 -3.2395568 Threonine/serine dehydratases met/aa

AGAP003000 -3.2334814 Predicted transporter ADD1 (major facilitator superfamily) - 12 predicted membrane helices

tr membrane

AGAP000731 -3.2260964 LIM domain only 1 - nucleolus - metal ion binding - regulation of transcription - zinc ion binding - nucleus - signalP detected

tm

AGAP010582 -3.2257924 Lipid exporter ABCA1 - 7 predicted membrane helices met/lipd membrane

AGAP005765 -3.2250586 Proteins containing BTB/POZ and Kelch , involved in regulatory/signal transduction processes

st

AGAP009875 -3.220536 cuticular protein 77, RR-1 family (AGAP009875-PA) Anopheles gambiae str. PEST - signalP detected

extmat

AGAP002053 -3.215696 Hypothetical secreted protein precursor - signalP detected s/

AGAP007402 -3.208809 Protein involved in DNA repair uc

AGAP008862 -3.2066617 Germ-line stem cell division protein Hiwi/Piwi; negative developmental regulator

nr

AGAP007609 -3.2043421 Hypothetical secreted protein precursor - signalP detected s/

AGAP008726 -3.2001224 eyes absent - response to light stimulus - salivary gland morphogenesis - mesoderm development - ovarian follicle cell development - compound eye - 12 NetOglyc sites

st

AGAP003058 -3.1959784 CLIP-domain serine protease subfamily B (AGAP003058-PA) Anopheles gambiae str. PEST - signalP detected

s/protease

AGAP008420 -3.195028 inhibitor of apoptosis protein (AGAP008420-PA) Anopheles gambiae str. PEST st/apoptosis

AGAP008412 -3.181117 40S ribosomal protein S3a Aedes aegypti ps

AGAP003860 -3.1783931 Proline oxidase met/aa

AGAP001259 -3.1575427 Src homology 2 st

AGAP007552 -3.1531181 U2-associated snRNP A' protein - 24 NetOglyc sites tm

AGAP007407 -3.1525204 Macrophage mannose receptor 1 - mannose binding - integral to plasma membrane - plasma membrane - receptor - sugar binding - receptor-mediated - signalP detected

st

AGAP010070 -3.1506603 Neural proliferation, differentiation and control protein - signalP detected st

AGAP007400 -3.1463804 Lysosomal & prostatic acid phosphatases - signalP detected s/met/lipd Lysosomal

AGAP008990 -3.1454396 Lecithin:cholesterol acyltransferase (LCAT)/Acyl-ceramide synthase met/lipd

AGAP011758 -3.1378999 PR domain containing 9 - methyltransferase - chromosome - regulation of transcription - meiosis - nucleus - transferase

tm

AGAP010282 -3.1373482 Mismatch repair ATPase MSH2 (MutS family) nr

AGAP007299 -3.1338904 Nuclear transport receptor RANBP7/RANBP8 (importin beta superfamily) ne

AGAP008532 -3.1314323 Adaptor protein Enigma st

AGAP003771 -3.1230104 DNA polymerase sigma DNA replication nr

AGAP009232 -3.1196575 Actin regulatory (gelsolin/villin family) cs

AGAP000772 -3.1136253 AGAP000772-PA Anopheles gambiae str. PEST uc

AGAP011250 -3.1120918 AGAP011250-PA Anopheles gambiae str. PEST uc

AGAP001644 -3.1113477 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 - cytoplasm - nitric oxide mediated signal transduction - catalytic - arginine catabolic process

st

AGAP010862 -3.110171 sodium-dependent nutrient amino acid transporter 2 - signalP detected - 2 predicted membrane helices

tr membrane

AGAP010406 -3.1080294 Origin recognition complex, subunit 3 nr

AGAP004524 -3.1076777 Cdc15/Fes/CIP4 domain-containing protein, PCH family protein, RhoGAP domain-containing protein - intracellular - regulation of Rac protein signal

st

AGAP005223 -3.1058266 Apolipoprotein D/Lipocalin - signalP detected extmat

AGAP003057 -3.0989017 CLIP-domain serine protease subfamily B (AGAP003057-PA) Anopheles gambiae str. PEST - signalP detected

s/protease

AGAP012637 -3.0908453 DNA-directed RNA polymerase (EC 2.7.7.6) II largestchain - mouse, PIR2:A28490 - chr4:6295604-6299755 REVERSE - Aliases: F28M11.1 - signalP detected

tm

AGAP002032 -3.0809004 Predicted lipoprotein - signalP detected s/met/lipd Predicted

AGAP008578 -3.0807629 ATP-dependent RNA helicase tm

AGAP001280 -3.0788004 inwardly rectifying k+ channel, Aedes aegypti - 3 predicted membrane helices - Membrane anchor detected

tr membrane membrAnchor

AGAP011386 -3.0763316 Amino acid transporters - 12 predicted membrane helices tr membrane

AGAP002807 -3.0728104 Transcription initiation factor TFIID, subunit BDF1 - 52 NetOglyc sites tm

AGAP010178 -3.0614338 Hypothetical secreted protein precursor - signalP detected s/

AGAP004426 -3.0478919 Fasciclin - signalP detected extmat

AGAP005625 -3.0474863 Trypsin - signalP detected s/met/aa Trypsin

AGAP004524 -3.0339148 Cdc15/Fes/CIP4 domain-containing protein, PCH family protein, RhoGAP domain-containing protein - intracellular - regulation of Rac protein signal

st

AGAP001964 -3.0217745 Trypsin-like serine protease - signalP detected s/protease

AGAP010234 -3.0141199 Microsomal triglyceride transfer protein - signalP detected s/met/lipd Microsomal

AGAP005456 -3.0007415 cuticular protein 15, RR-1 family (AGAP005456-PA) Anopheles gambiae str. PEST - signalP detected

extmat

Gene ID, along with the absolute fold-change, putative description and functional class are listed. Abbreviated titles of classes include: cs, cytoskeletal; extmat, extracellular matrix and adhesion; tr, transporters and channels; tf, transcription factor; tm, transcription machinery; ps, protein synthesis; pm, protein modification machinery; pe, protein export machinery; ne, nuclear export; prot, proteasome machinery; st, signal transduction; nr, nuclear regulation; met/aa, amino acid metabolism; met/carb, carbohydrate metabolism; met/lipd, lipid metabolism; met/energy, energy metabolism; met/nuc, nucleotide metabolism; met/int, intermediary metabolism; detox, detoxification; detox/ox, oxidant metabolism/detox; imm, immunity; uk, unknown; uc, unknown conserved; s/, secreted; te, transposable element; s/protinh, protease inhibitor; pm/protease, peptidases; st/apoptosis, apoptosis; vir, viral product.

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