value and responsible respiratory prescribing dr vince mak, consultant physician, nwlh trust
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VALUE AND RESPONSIBLE RESPIRATORY PRESCRIBING
Dr Vince Mak, Consultant Physician, NWLH Trust
Responsible Prescribing should be based on:
Evidence-Based Efficacy (Grade A)
Safe (primum non nocere)
Value
“clinicians will need to accept that they are responsible for the stewardship of resources and not just their use” Sir Muir Gray BMJ Oct 6 2012
What is Value?
Value Framework
Health Outcomes
CostValue=
Health Outcomes Cost of delivering
Outcomes
Porter ME; Lee TH NEJM 2010;363:2477-2481; 2481-2483
QUALITY vs VALUE
Quality and Value are not mutually exclusive
RIGHT CAREDo the right thingDo the right thing rightDoing the right thing right first time should deliver quality and value
To understand VALUE – you have to know COST
What are the top 5 costliest drugs in the NHS (Dec 2012)?
Source: www.drugtariff.co.uk
5. Seretide 125 evohaler - £81 million/yr4. Seretide 500 accuhaler - £85 million/yr3. Symbicort 200 - £90 million/yr2. Tiotropium - £120 million/yr1. Seretide 250 evohaler - £180 million/yrThus, of the top 5 costliest drugs to the NHS currently,
ALL ARE RESPIRATORY INHALERS
Why is Seretide 250 the commonest prescribed
combination inhaler in the NHS?
Position in BTS/SIGN Asthma Guidelines
Does this mean majority of asthmatics are at Step 4+ of BTS guidelines?
COPD NICE Guidance
Evidence of Overuse of Inhaled Corticosteroids in COPD
De la Rosa et al. ERJ 2011: P4627
Evidence from UKERS 2011, Sept. 26 — Many patients with chronic obstructive pulmonary disease (COPD) managed in primary care practices in the south of London are being overtreated with inhaled corticosteroids (ICS), according to researchers based at King's College in London, United Kingdom.
Co-investigator Dr. Hilary Pinnock from the Allergy and Respiratory Research Group at the University of Edinburgh, who presented the study on behalf of the research team, said the study findings show both the increased risk for patients and the excessive cost to the system that result from the inappropriate use of ICS.
In the study, data including spirometry, inhaled medications and recent COPD exacerbations were obtained for 3,537 patients with COPD at 65 general practices in Lambeth and Southwark.
Of patients included in the study, complete spirometry data were available for 61% and, in 71% of these cases, spirometry results confirmed the diagnosis of COPD. Only 60% of patients were being treated appropriately with 9% undertreated and 37% overtreated. Of those cases in which there was deemed to be overtreatment, inhaled steroids were involved in 96% of cases.
Pinnock said the main categories of overtreatment were overprescribing ICS in patients with less severe disease and in using ICS when there were no exacerbations of disease. Half of the patients for whom the diagnosis was not confirmed on spirometry were receiving ICS at high doses.
While the researchers conclude these findings "must give considerable cause for concern," Pinnock did note that the 2010 NICE guidelines "blur" the advice for when to use ICS and widen their indications.
COPD London Respiratory Team Value Pyramid - Cost/QALY
The low value pyramid?
Representation based on national GP contract data and locally retrieved data
Do less low value – Do more high value
Added value from doing things right (quality improvement)
Added value from doing the right things (making theright decisions)
High Value
HighValue
High Value
Low Value
Low Value
Do less low value – Do more high value
Are we getting the most out of our inhaler spend?
Doing the Right Things Right – Inhaler Technique
In some studies, up to 90% of patients may not be able to use an MDI effectively
91% of healthcare professionals who teach use of an MDI cannot demonstrate it correctly*
Even with effective technique, lung deposition from an MDI is at best 12% (excluding newer fine particle inhalers)**
Large volume spacer may be easier to use and may increase deposition to over 20%**
If used incorrectly – a lot of the drug from MDI is wasted
*Thorax 2010;65:A117
** Newman S. Chest 1985; 88: 152S-160S
SAFETY
* NNT to observe 1 extra pneumonia event on fluticasone propionate/salmeterol (FPS)† The TORCH and INSPIRE studies were not powered to investigate pneumonia
1. Crim C et al. Eur Respir J 2009; 34: 641-7.2. Calverley PM et al. Chest 2011; 139: 505-12.3. Janson C et al. ERS 2012.
Swedish RWE: Pneumonia data in context
Increased incidence of pneumonia with fluticasone propionate/salmeterol in studies with >2 yrs of follow up Pneumonia rate per 100 patient-years
PlaceboFPS 500 bdTiotropiumBF
Inhaled corticosteroid doses
Licensed doses for COPD (used in studies)
BF - Symbicort 400 Turbohaler 1p BDBeclometasone equivalence 800mcg/day
FS - Seretide 500 Accuhaler 1p BDBeclometasone equivalence 2000mcg/day
Risks of high dose ICS
D Price et al. Prim Care Respir J 2012;http://dx.doi.org/10.4104/pcrj.2012.00092
HPA suppression ✔
What can we do?
ENCOURAGE RESPONSIBLE RESPIRATORY PRESCRIBING
RIGHT CARE - Responsible Respiratory Prescribing
If your patients knew the risks – what would they chose?
Often – use of high dose inhaled corticosteroid not appropriate for stage of disease for asthma and COPD
In COPD – possible to use evidence based lower potency with same clinical efficacy
Poor inhaler technique often cause for treatment failure and not “fixed” by increasing the dose
Treatment rarely stepped down when stable or not effective
Lack of awareness of potential harm of high potency inhaled corticosteroids – would patients use if fully informed?
London Respiratory Team – Responsible Prescribing Messages
1. Respiratory medications are expensive
Doing the Right Things:
2. When prescribing any new respiratory inhaler, ensure that the patient has undergone NICE-recommended support to stop smoking
3. Pulmonary rehabilitation is a cost effective alternative to stepping up to triple therapy and should be the preferred option if available and the patient is suitable.
Doing the Right Things Right:
4. When prescribing any inhaled medication, ensure that the patient has undergone patient centred education about the disease and inhaler technique training by a competent trainer
5. When prescribing an MDI (except salbutamol), ensure that a spacer is also prescribed and will be used
6. When prescribing high dose inhaled corticosteroids (>1000ug BDP equivalent?), ensure that the patient is issued with an inhaled steroid safety card
Tools for change – Inhaled steroid card
?
Tools for change – Prescribing data
What can and will you do to encourage
Responsible Respiratory Prescribing?
Optimise – not Maximise
Do more of what is right!
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