v scf ras gdp inactive nucleus scf ras gdp inactive nucleus

v

SCF

Ras

GDP

Inactive

nucleus

SCF

Ras

GDP

Inactive

nucleus

v

SCF

Ras

GDP

Inactive

nucleus

v

SCF

Ras

GDP

Inactive

nucleus

v

SCF

Ras

GDP

Inactive

nucleus

v

SCF

Ras

GDP

Inactive

nucleus

v

SCF

Ras

GDP

Inactive

nucleus

v

SCF

Ras

GDP

Inactive

nucleus

v

SCF

Ras

GDP

Inactive

nucleus

v

SCF

Ras

GDP

Inactive

nucleus

v

SCF

Ras

GDP

Inactive

nucleus

v

SCF

Ras

GDP

Inactive

nucleus

v

SCF

Ras

GDP

Inactive

nucleus

v

SCF

Ras

GDP

Inactive

nucleus

v

SCF

Ras

GDP

Inactive

nucleus

v

SCF

Ras

GDP

Inactive

nucleus

v

SCF

Ras

GDP

Inactive

nucleus

v

SCF

Ras

GDP

Inactive

nucleus

v

SCF

Ras

GDP

Inactive

nucleus

v

SCF

Ras

GDP

Inactive

nucleus

v

SCF

Ras

GDP

Inactive

nucleus

Ras

GDP

Inactive

nucleus

Ras

GDP

Inactive

nucleus

Ras

GDP

Inactive

nucleus

Ras

GDP

Inactive

nucleus

Ras

GDP

Inactive

nucleus

Ras

GDP

Inactive

nucleus

Ras

GDP

Inactive

nucleus

Ras

GDP

Inactive

nucleus

Ras

GDP

Inactive

nucleus

Ras

GDP

Inactive

nucleus

Ras

GDP

Inactive

nucleus

Ras

GDP

Inactive

nucleus

Ras

GDP

Inactive

nucleus

Ras

GDP

Inactive

nucleus

Ras

GDP

Inactive

nucleus

Ras

GDP

Inactive

nucleus

Ras

GDP

Inactive

nucleus

Ras

GDP

Inactive

nucleus

Ras

GDP

Inactive

nucleus

Ras

GDP

Inactive

nucleus

Ras

GDP

Inactive

nucleus

Ras

GDP

Inactive

nucleus

Ras

GDP

Inactive

nucleus

Ras

GDP

Inactive

nucleus

Ras

GDP

Inactive

nucleus

Ras

GDP

Inactive

nucleus

Ras

GDP

Inactive

nucleus

P

P

P

P

P

PP

P

Ras

GDP

Inactive

Active!

nucleus

P

PP

P

Ras

GDP

Inactive

Active!

nucleus

P

PP

P

Ras

GDP

Inactive

Active!

nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

Src

P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Active!

P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Active!

P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Active!

P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Shc

P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Shc

P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Shc

P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Shc

P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Shc

P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Shc

P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Shc

P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Shc

P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Shc

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShc

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShc

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

GTP

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

GTP

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

Ras

GDPGTPP

PP

P

RasInactive

nucleus

SrcPShcP

Grb2 Sos

Ras

GDPGTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Active!

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Active!

InactiveRaf-1

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos Active!

Raf-1

MEK

Inactive

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

Inactive

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

Inactive

P

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

Active!

P

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

Active!

P

Erk

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

Active!

P

Inactive

Erk

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

Active!

P

Inactive

Erk

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Inactive

Erk

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Inactive

Erk

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Inactive

Erk

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Inactive

PP

Erk

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Active!

PP

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Erk PP

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Erk PP

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Erk PP

Erk PP

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Erk PP

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Erk PP

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Erk PP

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Erk PP

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Erk PP

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Erk PP

MEK

Ras

GTP

Ras

GTPP

PP

P

RasSrcPShcP

Grb2 Sos

Raf-1

P

Transcription!

Erk PP

MEK

Ras

GTP

Ras

GTPP

PP

P

RasSrcPShcP

Grb2 Sos

Raf-1

P

Transcription! cell growth

Erk PP

MEK

Ras

GTP

Ras

GTPP

PP

P

RasSrcPShcP

Grb2 Sos

Raf-1

P

Transcription! cell growth

Erk PP

MEK

Ras

GTP

Ras

GTPP

PP

P

RasSrcPShcP

Grb2 Sos

Raf-1

P

Transcription! cell growth

Erk PP

MEK

Ras

GTP

Ras

GTPP

PP

P

RasSrcPShcP

Grb2 Sos

Raf-1

P

Transcription! cell growth