the pharmacological
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7/27/2019 The Pharmacological
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Contents.......
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reface t o the First Edition xix
- . -
I I . Drug inventionand the Pharmaceutical
Suzanne M. Rivera and Alfred Goodman Gilman
&.~pharmaookipe~cs:heDynamics ofDrug! Absorption, Distribution,Metabolism,
.......................................................,andElimination 17
'Pain L. 0.Buxton and Leslie Z. Benet
Phannadynamics: MoIeeularMechanismsI--.
ofDmg Action .................................. ...................41.Donald IC Bhmenthal and ; l am6 C Garrison
prug Toxicity andPoisoning............... ..................73Kevin C. Osterhoudt and Trwor M. Penning
, 5. MembrmeTransportersandw u g Response........................................................ 89ka~lleen . Giammini and YuichiSugiyam
i 6. Drug Metalmlism ................................................. 123I -
' Frank J. Gonzalez, MichaelCoughtrie,? a n d Robert H . Tukey I . , ! , .. :
7. Phnrrnacogenetics., ......,. .;..<>....;............. ...........145Mary V. Relling and Kathleen M. Giacomini
beurottansmission:TheAutonomic
grid SomaticMotorNervous Systems................... 171Thomas C.westfalland David P Westfall
I , . I , , . . I.
9.Muscarinic ~ecep tor ~ o r f i ' g k , ' . , ' ' I,
. I . . - - ,' ,. ; , -. , , 4 , , 1 ;.:
and Antagonists....r? ....1
. , , . 1
Joan HetlerBrown and Nora Laiken
.... ...0.AnticholinesterslseAgents..............,.... ...Palmer Taylor
1 1. Agents Acting at the Neuromusculor
Junction andAutonomicGangh .........................Ryan E. tlibbs and A k n d e r C Zambon
12. Admergic Agonists andAntagonists.................Thomas C. Weiffatl and Oarid P WestFall
13.5-Hydroxy tryptamine (Seraonin)and Dapamine...................................................EIaineSanders-Bush and Lisa H a x e l w d
14. Neurotransrnission and the Central .Nervous System .;k~c~::4j:;:~;;?.; .... , .;:. i&;*:tPeny B. Molinoff , -
, , I,., , ,: : . i i m K r i15. DrugTherapy ofDepression , > ... I
and Anxiety Dkde r s........... . ..................... 2
James M. O'DonneU and Richard C. Shdton16.PharmacotherapyofPsychosis hm
andMania...............................................................Jonathan H. Meyer
17. Hypnotics and Sedatives.......................................S. John Mihic and R Admn ktarris
18.Opioids,Analgesia, and Pain
Management.....................................~...........~, ...Tony 1.Yaksh and Hark S. W a k e
18.GeneralAnesthetics and TherapeuticGnst .....Piyurh M. PateL HemalH. Patel,
'and David M. Roth
20.Local Anesthetics ..................................................William A. CattewU and Kbnneth bdde
......................J,,PRannacotherapy of he Epilepsies;James0. McNamara
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22.TreatmentofCentralNervous SystemDegenerativeDisorders........................................,09David G. Standaert and Erik D. Roberson
23. Ethanol andMethanol......................................... 629Marc A. Schuckit
24. Drug Addiction...................................................... 649
Chades P (r8rien
I Modutation of Caaiwascular
-Function 66925. Regulation ofRenal Function. and VascularVoIume ................................... 1........671
Robert F. Reilly and Edwin K. Jackson
26. Renin and Angiotensin .......................................... 721Randa Hilal-Dandan
27. Tkatment ofMymadial Ischemia
andHypertension ...............................,,..,.. JThomas Michel and Brian B, Hoffman
28. Phamacotherapyof Coagestive
Heart Failure., ...,..,.....,...,.......,...,,......,...,.a.-,............789Bradley A. Maron and Thomas P, Rocco
29.Anti-Arrhytfmic Drugs ......................................... 815Kevin 3. Sampson,and RobertS. Kass
30:BloodCoagulation qndAnticqqgNant,
Fibrinolytic, and AntiplateletDmgs.. ......,,........-849Jeffrey I. Weitz
31.Drugmerapy f ~ rypercholesterolemiaandDyslipidemia ..........................................%.......7'7Thomas P. +ot
and Hematopoiesis 909
32.Histamine, Bradykinin, and Their
.........................................................ntagoaists.. .91RandalA. Skid& AUen P &plan, and Elvin G. Erdiis
33. Lipid-DerivedAutacoids:Eicmmoidsand Platelet-Activ&tingFactor............................... 937Emer M. Smyth, Tilo Grosser, and Ga>r@ A. FibGerald
34. Anti-inflammatbry,Antipyreti4and Analgesic
........................gents; ~harrnacothqai~f Gout 959
Tilo Gmsser, Emr M. Smyth, a d GarretA. FibGerald
35.Tmmunosuppressants,Tolerogens,andImrnunostimulants..................... ,.................... 1 005
Alan M. Krensky, William H. enn nett, and wo Yfncenti
36.Plllrnonary Pharmacology.................................. .1M1
Peter 3. Barnes
37. HematopoieticAgents:GrowthF-,Minerals, andVitamins....................................... 1067
Kenneth thushandy and ThomasJ. Kipps
Hormones and HormoneAntagonists 3138. IntroductionToEndmrinology:
The~ypohhmi~l'ituitaryxis ...................... . IKeithL Parker and Bernard P Sd-hrnmer
...................9.Thyroid and Anti-Thyroid Drugs ....Gregory A. Brentand Ronald J. Kwnig
40. Esbgen s and Progestins. . . . . . . . . ~~~~~ms R. Lwin and Stephen R. Hamines
41. Androgens........................................................... 1Peter3. Snyder
42.ACTH,Adrenal Steroids,andPharmacology
.............................ftheAdrenalCortex.. . .1
Bernard P Schimmr and John W. Funder
43 .Endocrine Pancreas and Phmacotherapy.............f DiabetesMellitus and Hypoglycemia 12
Alvin C. Powers and DavidW A k m
44. AgentsAffectingMineral Io n
Homeostasisand Bone Turnover......................... 1
Peter A. Friedman
BECT~ON I-. ..- -- - .
Drugs Affecting Gastrointestinal
~ u n d o n 1345. fiarmacotherapy of GastricAcidity, Peptic
Ulcers, andGastroesophagealReflux Disease ... I3John L. Wallace an d Keith A. Sharkey
46.Treatment-of Disorders of BowelMotility andWaterHux;:Anti-Emetics;Agents Used in
Biliary and Pandrkatic ,Disease ...........................Keith A. Sharkey an d John L. Wallace
47. Phmacotherapy df InflammatoryBowelWsease............................................... 1
John L. Wallace and Keith A, Sharkey
Diseases 1348. General Principles ofAntimicrobial
............. ...................................herapy , 1Tawanda Gumbo
49. Chemothempy ofMalaria .................................13Joseph M. Vinetr, Jbrbme Ctain, Vlengngeun Bounkeua,
Wchard T Eastman, and David Fidock b A v y l rH
50. Chemotherapy of Protozoal Infections:Amebiasis, Gid ias i s ,Trichomoniasis, a!.Try anosomiasis.Leishmaniasis,and Other
Protoml Infections............................................ 14Margaret A. PhiUipr andSamuet L Stanley, Jr.
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