the mouse (mus musculus) t cell receptor beta variable

IMGT Locus in Focus

Exp Clin Immunogenet 2000;17:216–228

The Mouse (Mus musculus) T CellReceptor Beta Variable (TRBV),Diversity (TRBD) and Joining (TRBJ)Genes

Nathalie Bosc Marie-Paule Lefranc

Laboratoire d’ImmunoGénétique Moléculaire, Institut de Génétique Humaine, CNRS,Université Montpellier II, Montpellier, France

Received: April 28, 2000

Prof. Marie-Paule Lefranc, IMGT, Laboratoire d’Immuno GénétiqueMoléculaire, LIGM, UPR CNRS 1142, IGH, 141 rue de la CardonilleF–34396 Montpellier Cedex 5 (France)Tel. +33 4 99 61 99 65, Fax +33 4 99 61 99 01E-Mail lefranc@ligm.igh.cnrs.fr, IMGT: http://imgt.cines.fr:8104

ABCFax + 41 61 306 12 34E-Mail karger@karger.chwww.karger.com

© 2000 S. Karger AG, Basel0254–9670/00/0174–0216$17.50/0

Accessible online at:www.karger.com/journals/eci

Key WordsMouse genes W IMGT W T cell receptor W Betavariable regions W Beta diversity regions W

Beta joining regions

Abstract‘The Mouse (Mus musculus) T cell ReceptorBeta Variable (TRBV), Diversity (TRBD), andJoining (TRBJ) Genes’, the 14th report of the‘IMGT Locus in Focus’ section, comprises 8tables entitled: (1) ‘Number of mouse (Musmusculus) germline TRBV genes at 6A–C andpotential repertoire’; (2) ‘Mouse (Mus mus-culus) germline TRBV genes at 6A–C’; (3)‘Mouse (Mus musculus) TRBV allele table’;(4) ‘Mouse (Mus musculus) germline TRBDgenes and alleles’; (5) ‘Mouse (Mus muscu-lus) germline TRBJ genes’; (6) ‘Mouse (Musmusculus) TRBJ allele table’; (7) ‘Correspon-dence between the different mouse (Musmusculus) TRBV gene nomenclatures’; (8)‘Mouse (Mus musculus) TRBV genes and re-lated human TRBV genes’. These tables are

available at the IMGT Marie-Paule page fromIMGT, the international ImMunoGeneTicsdatabase (http://imgt.cines.fr:8104) createdby Marie-Paule Lefranc, Université Montpel-lier II, CNRS, Montpellier, France.

Copyright © 2000 S. Karger AG, Basel

Introduction

‘The Mouse (Mus musculus) T cell Recep-tor Beta Variable (TRBV), Diversity (TRBD)and Joining (TRBJ) Genes’ is the 14th report ofthe ‘IMGT Locus in Focus’ section launched inthe April 1998 issue of Experimental and Clin-ical Immunogenetics [1–14]. The completerepertoire of the human germline TRBV,TRBD and TRBJ genes has previously beenreported [8, 11, 14]. This 14th report on themouse (Mus musculus) T cell receptor betavariable, diversity and joining genes describes,for the first time, the complete murine germ-line TRB repertoire, with the same standard-ized rules of the IMGT scientific chart [15]

Mouse TRBV, TRBD and TRBJ Genes Exp Clin Immunogenet 2000;17:216–228 217

which were used for the description of thehuman TRB repertoire [8, 11, 14]. This reportcomprises 8 tables entitled: (1) ‘Number ofmouse (Mus musculus) germline TRBV genesat 6A–C and potential repertoire’; (2) ‘Mouse(Mus musculus) germline TRBV genes at 6A–C’; (3) ‘Mouse (Mus musculus) TRBV alleletable’; (4) ‘Mouse (Mus musculus) germlineTRBD genes and alleles’; (5) ‘Mouse (Musmusculus) germline TRBJ genes’; (6) ‘Mouse

(Mus musculus) TRBJ allele table’; (7) ‘Corre-spondence between the different mouse (Musmusculus) TRBV gene nomenclatures’; (8)‘Mouse (Mus musculus) TRBV genes and re-lated human TRBV genes’. These tables areavailable at the IMGT Marie-Paule page fromIMGT, the international ImMunoGeneTics da-tabase (http://imgt.cines.fr:8104) created byMarie-Paule Lefranc, Université MontpellierII, CNRS, Montpellier, France [15, 16].

218 Exp Clin Immunogenet 2000;17:216–228 Bosc/Lefranc

Mouse TRBV, TRBD and TRBJ Genes Exp Clin Immunogenet 2000;17:216–228 219

220 Exp Clin Immunogenet 2000;17:216–228 Bosc/Lefranc

Mouse TRBV, TRBD and TRBJ Genes Exp Clin Immunogenet 2000;17:216–228 221

222 Exp Clin Immunogenet 2000;17:216–228 Bosc/Lefranc

Mouse TRBV, TRBD and TRBJ Genes Exp Clin Immunogenet 2000;17:216–228 223

224 Exp Clin Immunogenet 2000;17:216–228 Bosc/Lefranc

Mouse TRBV, TRBD and TRBJ Genes Exp Clin Immunogenet 2000;17:216–228 225

226 Exp Clin Immunogenet 2000;17:216–228 Bosc/Lefranc

Mouse TRBV, TRBD and TRBJ Genes Exp Clin Immunogenet 2000;17:216–228 227

228 Exp Clin Immunogenet 2000;17:216–228 Bosc/Lefranc

Acknowledgments

We thank Valérie Contet for contribution to themanuscript and Gérard Lefranc for helpful discussion.IMGT is funded by the European Union’s BIOTECHprogramme (BIO4CT96-0037), the Centre National dela Recherche Scientifique, the Ministère de l’Educa-

tion Nationale, and the Ministère de la Recherche.Subventions have been received from the Associationpour la Recherche sur le Cancer, Association de laRecherche sur la Polyarthrite, Fondation pour la Re-cherche Médicale, Ligue Nationale contre le Cancerand the Région Languedoc-Roussillon.

References

1 Lefranc MP: IMGT locus on focus:A new section of Experimental andClinical Immunogenetics. Exp ClinImmunogenet 1998;15:1–7.

2 Pallarès N, Frippiat JP, GiudicelliV, Lefranc MP: The human immu-noglobulin lambda variable (IGLV)genes and joining (IGLJ) segments.Exp Clin Immunogenet 1998;15:8–18.

3 Barbié V, Lefranc MP: The humanimmunoglobulin kappa variable(IGKV) genes and joining (IGKJ)segments. Exp Clin Immunogenet1998;15:171–183.

4 Martinez C, Lefranc MP: Themouse (Mus musculus) immuno-globulin kappa variable (IGKV)genes and joining (IGKJ) segments.Exp Clin Immunogenet 1998;15:184–193.

5 Pallarès N, Lefebvre S, Contet V,Matsuda F, Lefranc MP: The hu-man immunoglobulin heavy vari-able (IGHV) genes. Exp Clin Immu-nogenet 1999;16:36–60.

6 Ruiz M, Pallarès N, Contet V, Bar-bié V, Lefranc MP: The humanimmunoglobulin heavy diversity(IGHD) and joining (IGHJ) seg-ments. Exp Clin Immunogenet1999;16:173–184.

7 Scaviner D, Barbié V, Ruiz M, Le-franc MP: Protein displays of thehuman immunoglobulin heavy,kappa and lambda variable andjoining regions. Exp Clin Immuno-genet 1999;16:234–240.

8 Folch G, Lefranc MP: The human Tcell receptor beta variable (TRBV)genes. Exp Clin Immunogenet 2000;17:42–54.

9 Scaviner D, Lefranc MP: The hu-man T cell receptor alpha variable(TRAV) genes. Exp Clin Immuno-genet 2000;17:83–96.

10 Scaviner D, Lefranc MP: The hu-man T cell receptor alpha joining(TRAJ) genes. Exp Clin Immuno-genet 2000;17:97–106.

11 Folch G, Lefranc MP: The human Tcell receptor beta diversity (TRBD)and beta joining (TRBJ) genes. ExpClin Immunogenet 2000;17:107–114.

12 Artéro S, Lefranc MP: The teleosteiimmunoglobulin heavy IGH genes.Exp Clin Immunogenet 2000;17:148–161.

13 Artéro S, Lefranc MP: The teleosteiimmunoglobulin light IGL1 andIGL2 V, J and C genes. Exp ClinImmunogenet 2000;17:162–172.

14 Folch G, Scaviner D, Contet V, Le-franc MP: Protein displays of thehuman T cell receptor alpha, beta,gamma and delta variable and join-ing regions. Exp Clin Immunogenet2000;17:205–215.

15 Lefranc MP, Giudicelli V, Gines-toux C, Bodmer J, Müller W, Bon-trop R, Lemaı̂tre M, Malik A, Bar-bié V, Chaume D: IMGT, the inter-national ImMunoGeneTics data-base. Nucleic Acids Res 1999;27:209–212.

16 Ruiz M, Giudicelli V, Ginestoux C,Stoehr P, Robinson J, Bödmer J,Marsh S, Bontrop R, Lemaı̂tre M,Lefranc G, Chaume D, Lefranc MP:IMGT, the international ImMuno-GeneTics database. Nucleic AcidsRes 2000;28:219–221.