the hvtn is supported through a cooperative agreement with the national institute of allergy and...

The HVTN is supported through a cooperative agreementwith the National Institute of Allergy and Infectious Diseases

HVTN 505Lessons learned in year 1

Niles Eaton, MPHManager, Community Education Unit

HVTN Core Operations Center

Draft – 12 Nov 2010

HIV Vaccine trials in US MSM at high risk

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200

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CumulativeExpected

CumulativeEnrolled

Where are we now?

5/30

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9

6/25

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7/21

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8/16

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9/11

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10/7

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11/2

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11/2

8/20

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12/2

4/20

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1/19

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2/14

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3/12

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4/7/

2010

5/3/

2010

5/29

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6/24

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7/20

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8/15

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9/10

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10/6

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11/1

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11/2

7/20

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12/2

3/20

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1/18

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1

2/13

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3/11

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1

4/6/

2011

5/2/

2011

5/28

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6/23

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7/19

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8/14

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9/9/

2011

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CumulativeExpected

CumulativeEnrolled

5/30

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7/1/

2009

7/17

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8/2/

2009

8/18

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9/19

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1/9/

2010

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2/26

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4/15

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5/1/

2010

5/17

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2010

6/18

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7/4/

2010

7/20

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8/5/

2010

8/21

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9/6/

2010

9/22

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10/8

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10/2

4/20

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11/9

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11/2

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12/1

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12/2

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1/12

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CumulativeExpected

CumulativeEnrolled

HVTN 505 enrollment, an iterative process

Version 2.0 approved: risk criteria simplification & specific language on

transgender

Initial Core-generated materials available

Amendment: upper age limit elevated to 50

Rapid needs assessment of all sites

Site expansion process

Strategies Initiated by HVTN Core: May 2010

Working Only So-So Not Working N/A In Process (TBD)

Hope Takes Action web contacts 3 6 1

Facebook Ads 1 2 3 3 1

Banner ads on hook-up websites 1 2 7Twitter 5 4 1

Media stories initiated by HVTN Core 3 6 1

Transit advertising (bus, train, etc.) 2 3 1 4

Bus bench/shelter ads 1 2 3 4

Phone kiosk ads 1 9

Print ads in local paper(s) 4 2 3 1

Hope Takes Action Posters 2 2 5 1

Hope Takes Action Palm cards 2 5 2 1

Hope Takes Action Post Cards 1 5 2 2

Hope Takes Action small poster w/ tear-off pads 2 2 5 1

Hope Takes Action drink coasters 2 1 7Hope Takes Action give-away items: Condoms 3 4 3

Hope Takes Action give-away items: Bags 4 3 3

Hope Takes Action give-away items: Lip Balm 5 3 2

Hope Takes Action give-away items: Yo-Yos 7 1 2

Hope Takes Action give-away items: Gum 8 1 1Hope Takes Action give-away items: Hand Sanitizer 6 2 2

Other give-aways (rubber duckies, etc.) 1 1 8

Cling ads for bathroom posting 1 7 2

Hope Takes Action table tents 1 3 4 2

T-shirts for recruiters 3 3 2 2

Not Working: - Banner ads on hook-up sites- Twitter- Media stories generated by HVTN Core-Hope Takes Action:

- Action Posters - Small posters with tear offs

- Coasters- Cling ads

Working:-Hope Takes Action give-aways

Lip BalmYo-yosGumHand Sanitizer

Survey of HVTN 505 sites, May 2010Referral Source:

Screened EnrolledBar/Street/Other Outreach 312 66 (38%)Internet 398 40 (23%)Core placed ads 153 10 (6%)Site placed ads/flyers 354 23 (13%)Other (referrals, rollovers, unk) 240 30 (18%)To be classified 28 2 (<1%)

1485 171

*missing: Birmingham, Los Angeles, VRC

Survey of HVTN 505 sites, Sep 2010Referral Source:

Screened EnrolledBar/Street/Other Outreach 576 145 (39%)Pride activities 49 6 (<1%)

Internet 334 80 (22%)Core placed ads 144 23 (6%)Site placed ads/flyers 245 46 (12%)Other (referrals, rollovers, unk) 257 67 (18%)To be classified 1 3 (<1%)

Total 1606 370

CEU & Legacy Project staffSite Visits

Main objective: assess recruitment & screening process for any obvious gaps

Collect & disseminate best practices Provide recommendations Report to Community Affairs & Site

Assistance Working Group (CASA) for additional review & feedback

HVTN 505 branding: evolution & customizing

Jul-09 Aug-09

Sep-09

Oct-09

Nov-09

Dec-09

Jan-10 Feb-10

Mar-10

Apr-10

May-10

Jun-10 Jul-10 Aug-10

Sep-10

Oct-10

Nov-10

(half)

0

10000

20000

30000

40000

50000

60000

Visitors to HopeTakesAction.org

Web & social media: generating contacts

Jul-09 Aug-09

Sep-09

Oct-09

Nov-09

Dec-09

Jan-10 Feb-10

Mar-10

Apr-10

May-10

Jun-10 Jul-10 Aug-10

Sep-10

Oct-10

Nov-10

(half)

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Contact Cards completed

New campaigns launched

Changed Facebook ad targeting

Site developed brands & materials

Summary of lessons learned

It can take time for the community to respond to a study starting up

Make materials available prior to study start, or plan on “lead-in” period

Evaluate, tweak & refresh strategies, campaigns and processes

R E L E N T L E S S L Y

Summary of lessons learned

Recognize the balance between local site initiatives and national campaigns, and accommodate

Sites can have other priorities Recognize and acknowledge good work

when you see it

Acknowledgements

The site staff making first contact with potential participants

The trial participants, without whom this work would not be possible