the firing rate‐lfp relaon changes as a funcon of firing...

TheFiringRate‐LFPRela1onChangesasaFunc1onofFiringRateinHumansAshwinG.Ramayya1,JeremyR.Manning1,JoshuaJacobs3,MichaelJ.Kahana2

1NeuroscienceGraduateGroupand2DepartmentofPsychology,UniversityofPennsylvania,Philadelphia,PA3Dept.ofBioengineering,DrexelUniversity,Philadelphia,PA

Introduc1onSlidingwindowanalysisrevealsnon‐linearityinFR‐LFPrela1on

Broadband+Neurons(n=453) Gamma+Neurons(n=141)

1/f“pinknoise”:calculatedasmeanofRobust‐fitline

Regressionframeworkseparatesbroadbandandgammacorrela1ons

Correlatedwithsingleneuronfiringrate

Broadbandpower(2‐150Hz)isnotanoscilla1on

References

Concave‐Up(n=285)

NotQuadra1c(n=128)

Concave‐Down(n=40)

Concave‐Up(n=68)

NotQuadra1c(n=47)

Concave‐Down(n=26)

18%

33%

48%63%

28%

8%• Extracellularrecordings20paVents• VirtualNavigaVonTask• 2,030neuronsidenVfied• SpikesremovedfromLFP• Analyzedin500msepochs

Conclusions

LFP=Summedac1vityofallneurons

FiringRate=Spikingac1vityofsingleneuron

2Modesofasingleneuron “Entrained”to

NetworkIndependentAcVvity

FiringRate

LFP

LFP

FiringRate

HighFiringRates

LowFiringRates

NetworkatRest Networkattask

LFP

FiringRate

LFP

FiringRate

LFP

FiringRate

20percenVlewindow

Power

Frequency

Broadbandpower

Narrowbandpower

NarrowbandOscillaVon

Singleneuronfiringratehasbeenwidelycorrelatedwithgammapower(30‐150Hz)ofthelocalfieldpotenVal(LFP)1.Recentevidencesuggeststhatbroadbandpower(2‐150Hz)isanotherelectrophysiologicalcorrelateofsingleneuronfiringrateinhumans2.

Firingrate

Results

Classifying+correlatedneuronswithaquadra1cfit Possiblemodelofconcave‐upneurons

+CorrelaVon

‐CorrelaVon

Firingrate(Hz)

Firingrate(Hz)

Firingrate(Hz)

Firingrate(Hz)

Firingrate(Hz)

Firingrate(Hz)

Mean=2.7

Mean=3.0

Mean=3.2

Mean=2.9

Mean=2.3

Mean=2.9

3subpopulaVonsofBB+andgamma+neurons(fig.4):1.  Concave‐up:Mostcommon;FR‐LFPwellcorrelatedat

highfiringratesbutnotatlowfiringrates(seefig.5“possiblemodel”)

2.  NotQuadra1c:PosiVvelycorrelatedneuronsdisplayingeitherlinearorhigherorderFR‐LFPrelaVons.

3.  Concave‐down:Leastcommon;FR‐LFPwellcorrelatedatlowfiringratesbutnotathighfiringrates.Previouslydescribedinmonkeyliterature3.

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1.  Whijngstall,K.andLogotheVs,N.(2009).Frequency‐BandCouplinginSurfaceEEGReflectsSpikingAcVvityinMonkeyVisualCortex.Neuron,64(2):281–289.

2.Manning,J.,Jacobs,J.,Fried,I.,andKahana,M.(2009).BroadbandshimsinLFPpowerspectraarecorrelatedwithsingle‐neuronspikinginhumans.JournalofNeuroscience,29(43):13613–13620.3.MazzoniA,WhijngstallK,BrunelN,LogotheVsNKandPanzeriS(2009).UnderstandingtherelaVonshipsbetweenspikerateanddelta/gammafrequencybandsofLFPsandEEGsusingalocalcorVcalnetworkmodel.Neuroimage,52(3):956‐972