stats 11, winter 2004
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Stats 11, Winter 2004
Experimental Design
Jan 9, 2004
London Cholera Outbreak, 1854
• Cholera kills quickly
• Primary symptom is severe diarrhea
• Modern treatment involves an IV to provide hydration
• Competing Theories for transmission: air vs water (germs). Air was the predominant view.
Golden Square, Sept 1854
• Unusually intense, deadly outbreak
• 500 deaths in just a few days
• Local panic made neighbors flee
• John Snow, a physician, believed cholera spread through polluted water supplies
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Is this definitive "proof"?
Same picture, but with daily deaths
Aside: quarterly aggregates
Fiscal Year aggregates
Calendar Year aggregate
Water compnies
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This area was fed by two water companies
Deathrate less where clean water
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Current medical mystery
• Sudan's Luckless Children, Locked in Land of Nod, NY Times, Sept 22, 2003
• Mysterious ailment among some children of Sudan
• Nod, don't grow fully, die in late teens• Theories: fly bite, poison,
contaminated food
References found on
• http://www.ph.ucla.edu/epi/snow.html
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