statistical and computationalstatistical and computational ... · statistical and...

Statistical and computationalStatistical and computational

challenges in genetics and evolutionchallenges in genetics and evolution

Ziheng Yang

Professor of Statistical Genetics, FRS

Galton Laboratory

GEE

UCL

speciation

speciation

H GC

speciation

speciation

G

Firstattempt:20K genesfor 36species,200GB RAM

Bayesian dating of divergences of mammalsBayesian dating of divergences of mammals

biological networks (Andrewbiological networks (Andrew PomiakowskiPomiakowski))

Mapping disease genes through genomeMapping disease genes through genome--widewideassociation studies (David Balding, Vincentassociation studies (David Balding, Vincent PlagnolPlagnol))

Origin of milk drinking in Europe &persistence of lactose: Co-evolutionof genes and culture revealed by ABC

Mark Thomas

Research driven by biological questions and data.

Involves statistical/mathematical modelling &

computation-intensive inference (ML, Bayesian, MC, MCMC, MC3)

Computational Biology in GEE/UGI/CoMPLEX

David BaldingJulia DayJim Mallet

Nikolas ManiatisDavid Murrell

Vincent PlagnolAndew Pomiankowski

Max TelfordMax Reuter

Mark ThomasZiheng Yang

EvolutionPopulation genetics

Molecular phylogeneticsComparative genomics

Biological NetworksMedical genetics

DevelopmentBiodiversity

Ecology

Stats &Maths Computation