sickle cell anemia
Post on 05-Jan-2016
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Sickle Cell Anemia
1) Single nucleotide substitution (“point mutation”) in the genefor the beta chain of hemoglobin.
3) Beta chain synthesized from the sickle-cell allele does not“fold” correctly and hempglobin molecules “clump” togetherforming a red blood cell that resembles a sickle.
2) Different amino acid gets placed in the peptide chain..
4) Sickled cells die early (10-20 days vs. 120 days) producing anemia.
5) Sickled cells clog the fine capillaries, leading to lack of oxygen intarget organs.
http://bio.winona.msus.edu/berg/308s04/Lec-note/19-new.htm
Rapid breakdownof sickled cells
Hemoglobin molecules “clump”
Sickle-shape red blood cells
Skeletalproblems
Impededcirculation
Organdamage
PainInfection
risk
Overactivebone marrow
FatigueImpaired
development
Anemia
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowSection&rid=gnd.section.98
http://peptide.ncsa.uiuc.edu/tutorials_current/Sickle_Cell_Anemia/SC2001/intro.html
http://www.blackwellpublishing.com/ridley/images/sickle_cell_anaemia.jpg
http://anthro.palomar.edu/synthetic/synth_7.htm
Why is SCA so common in some areas?
http://anthro.palomar.edu/synthetic/synth_7.htm
Different origins (independent mutations) of the SCD allele
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