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UBICCONSULTING
Science Market Regulation
Marketing development Strategy consulting Partnership searches Information systems
THE WORLD LACTOFERRIN AND LACTOPEROXIDASE MARKET
2 0 1 5
350 pages
This comprehensive report is based on in-depth interviews with food companies completed by a desk review.
It provides for DECISION MAKERS a global understanding of the sector as well as an outlook on its future.
SCIENCE – MARKET – REGULATION - MANUFATURERS
New trends and perspectives Use of ingredients: volumes-valueManufacturers profilesUser’s opinionRegulation
North AmericaWestern and Eastern EuropeAsiaAustralia- New Zealand
Food industryCosmeticsPharmacyIndustrial markets
LactoferrinLactoperoxidase
MARKET ANALYSIS
INGREDIENTS
FOOD SEGMENTS
COUNTRIES COVERED
350 pages
O B J E C T I V E S
M A R K E T
Industrial users needs,
expectations and volumes
Applications in segments
and consumption trends
Consumer market trends by
food segments
Prospective and forecast
M A N U F A T U R E R S
Processes and capacities
Market share
Company description
R E S E A R C H
New researches and
developments
New applications
SCIENCE – MARKET – REGULATION - MANUFATURERS
O B J E C T I V E S
M A R K E T
Industrial users needs,
expectations and volumes
Applications in segments
and consumption trends
Consumer market trends by
food segments
Prospective and forecast
M A N U F A T U R E R S
Processes and capacities
Market share
Company description
R E S E A R C H
New researches and
developments
New applications
It is now over 40 years since lactoferrin was
first isolated. Lactoferrin, which belongs to the
transferring family of proteins, is a 70-80 kDa
single sub-unit glycoprotein and consist of two
domains, each with one iron-binding site that
requires synergistic binding of a bicarbonate
anion. A conformational change in the binding
site, between open or closed forms, accompanies
iron binding and release. The affinity of
lactoferrin for iron is much greater than of
transferrin which functions as an iron carrier in
serum. In the “natural state”, lactoferrin is only
partly saturated with iron (5-30%) and has a
salmon color, the intensity of which depends on
the degree of iron saturation.
It is present in human milk, and many exocrine
fluids (saliva, mucous secretion) as well as
mammalian.
INTRODUCTION
THE WORLD LACTOFERRIN AND LACTOPEROXIDASE MARKET
Lactoferrin concentration in different sources
Bovine milk 200 mg/l
Bovine colostrum 1g/l
Human milk 2-4 g/l
Human colostrum 6-8 g/l
Bovine LF and human LF have approximately
69% of similarities in amino acid residues.
Human milk is the most abundant source of LF. It
is one of the major whey proteins in human milk
with concentrations of 1.4–2.0 mg mL-1 but only
a minor component in bovine milk with only one
tenth (0.1–0.2 mg mL-1) of concentration found
in human milk.
Lactoperoxidase is a hemoprotein that
catalyzes the oxidation of thyocyanate and iodide
ions in the presence of hydrogen peroxide to
produce highly reactive oxidizing agents. These
products have a broad spectrum of antimicrobial
effects. They can kill viruses, gram positive and
gram negative bacteria, fungi, and probably also
mycoplasmas and parasites.
This enzyme is primarily found in such exocrine
secretions as saliva, lachrymal fluid and milk,
cervical mucous and nasal glands. Human milk
does not appear to contain lactoperoxidase
(Tenovuo, 1985). However, a more recent study
confirmed the presence of lactoperoxidase in
human colostrum.
In milk, lactoperoxidase is one of the non
immunoglobulin protective proteins and its
antibacterial activity in raw milk was suggested
as early as 1924.
Bovine milk contains about 20 times higher LP
than that of human milk (Gothefors and
Marklund 1975) and it is the second most
abundant enzyme (De Wit and Van Hooydonk
1996) in bovine milk.
Milk
Water
Minerals
Lactose
Proteins
Whey
Whey Protein Concentrate
Immunoglobulin
Alpha-Lactalbumine
Beta - Lactalglobuline
Bovine Serum
Albumin
Lactoferrin
Lactoperoxidase
Peptides
Whey Protein Isolate
Delactosed & Demineralized
whey
Caseins
Phosphocaseinates
Rennet Casein
Ionic Casein Caseinates
Lactic Casein
O B J E C T I V E S
M A R K E T
Industrial users needs,
expectations and volumes
Applications in segments
and consumption trends
Consumer market trends by
food segments
Prospective and forecast
M A N U F A T U R E R S
Processes and capacities
Market share
Company description
R E S E A R C H
New researches and
developments
New applications
THE WORLD LACTOFERRIN AND LACTOPEROXIDASE MARKET
O B J E C T I V E S
M A R K E T
Industrial users needs,
expectations and volumes
Applications in segments
and consumption trends
Consumer market trends by
food segments
Prospective and forecast
M A N U F A T U R E R S
Processes and capacities
Market share
Company description
R E S E A R C H
New researches and
developments
New applications
FUNCTIONALITIES
THE WORLD LACTOFERRIN AND LACTOPEROXIDASE MARKET
In many ways, lactoferrin has been an easy
protein to investigate; however, there have been
difficulties understanding specific
structure/function relationships, particularly as it
functions in vivo;
Heat stability: At low ionic strength and/or low
pH, the resistance of lactoferrin to heat
denaturation is good and methods for heats
treatment and pasteurization have been
published.
Iron bioavailability: Two features of the
functional properties of lactoferrin are its ability
to bind iron exceptionally tightly and the coupling
of rigid-body domain movements to iron bindings
and release.
Anticarcinogenic effect: Lactoferrin has been
reported to inhibit cancer growth by inducing
apoptosis and stimulating the production of
critical cytokines, such as IL-18 etc.
Antimicrobial agent: Its capacity to bind iron
and to stay bound with iron until pH 3 interfer in
the proliferation of pathogen bacteria.
Antiviral agent: Recently, Antiviral activity has
been described as well for herpes, cytomegalo
and influenzes virus.
Inflammatory and Immune response:
Lactoferrin has various effects on the immune
system, such as regulation of antibody
production, complement activation, and natural
killer cell function.
Anti-oxidant effect: Lactoferrin scavenges
excess iron thereby protects the host to
peroxidation reactions.
� Lactoperoxidase can be combined to
lactoferrin in protection of the mucosal surface
and prevention of tooth decays.
Lactoperoxidase could elicit with bacteriostatic
and/or bactericidal activity on a variety of
susceptible microorganisms including bacteria,
fungi and viruses. The molecular mechanism (s)
of such inhibitory effects depend on the type of
electron donor, test media, temperature and pH
and could range from oxidative killing to
blockage of glycolytic pathways or interference
in cytopathic effects;
Antibacterial Effect: Gram-negative, catalase-
positive organisms, such as pseudomonas,
coliforms, salmonellae and shigellae, are not
only inhibited by the lactoperoxidase system
(LPS) but also, depending on the medium
conditions (pH, temperature, incubation time,
and cell density) may be killed. Gram-positive,
catalase negative bacteria, such as streptococci
and lactobacilli are generally inhibited but not
killed by the LPS.
Antifungal Effect: Seifu et al. declared that LPS
in goat milk inhibit growth and proliferation of
many fungal species viz., Aspergillus flavus,
Penicillium chrysogenum, Trichoderma spp.,
Alternaria spp. and Claviceps spp., Corynespora
cassicola, Phytophthora meadii and Corticium
salmonicolor; however, Candida albicans and
Pythium spp. were not affected by the this
system.
Antiviral Effect: Shin et al. reported the
potential of oral administration of LPS to
attenuate pneumonia in influenza-virus-infected
mice through the suppression of infiltration of
inflammatory cells in the lung.
O B J E C T I V E S
M A R K E T
Industrial users needs,
expectations and volumes
Applications in segments
and consumption trends
Consumer market trends by
food segments
Prospective and forecast
M A N U F A T U R E R S
Processes and capacities
Market share
Company description
R E S E A R C H
New researches and
developments
New applications
THE WORLD LACTOFERRIN AND LACTOPEROXIDASE MARKET
Based on the physiological, biological and
functional properties attributed to lactoferrin
and lactoperoxidase, there are a number of
interesting and innovative possibilities for
the application of these bio-active proteins
extracted from bovine milk.
APPLICATION RANGE
Functionality Food products
Infant formula
Sports and functional food
Pharmaceuticals Veterinary and feed
specialties
Personal care products
Lact
ofer
rin
Iron absorption � � �
�
Anti-inflammatory
� � �
Intestinal flora protection
� � � � �
Antibacterial � � �
Immune cell stimulation
� � � �
Antioxidant � � �
Lact
oper
oxid
ase Antimicrobial � � �
Anti-inflammatory in guts
� �
Intestinal flora protection
� � � �
Some of the applications are related to the
natural presence of lactoferrin and
lactoperoxidase in the human secretions: milk,
saliva, tears.
The following table will describe the potential
applications of lactoferrin and lactoperoxidase.
O B J E C T I V E S
M A R K E T
Industrial users needs,
expectations and volumes
Applications in segments
and consumption trends
Consumer market trends by
food segments
Prospective and forecast
M A N U F A T U R E R S
Processes and capacities
Market share
Company description
R E S E A R C H
New researches and
developments
New applications
OUTLOOK OF THE MARKET
THE WORLD LACTOFERRIN AND LACTOPEROXIDASE MARKET
There is a high level of competition with certainlarge companies that have worked on lactoferrinand lactoperoxidase for more than 20 years.
Lactoferrin has present applications in the dietetic field (food or OTC drug) and more anecdotically oral hygiene and in animal care nutrition.
Lactoferrin Market in tons
Segment 1997 2001 2007 2008 2011 2012
FOOD & NUTRITION
• Infant formula• Food
supplements• Dairy products• Others (meat,
etc)PHARMACEUTICALS
• Iron tablets• Immune system
stimulation• Health of
intestinal floraCOSMETICs and HYGIENE• skin care• body care• Oral hygieneOTHERSTOTAL
THE WORLD LACTOFERRIN AND LACTOPEROXIDASE MARKET
Lactoferrin Market Forecast in tonsSegment 2011 2012 2013 2014 2015
Infant Formula
Food & Nutrition
• Food Supplements
• Dairy Products
• Others (Meat, etc.)
Pharmaceuticals
Cosmetics & Hygiene
Others
Total
TABLE OF CONTENT
THE WORLD LACTOFERRIN AND LACTOPEROXIDASE MARKET
Methodology 10SUMMARY AND CONCLUSIONS 12Highlights 12Potential Market 13Price 14Competition 17Strategy and key success factors 18Lactoferrin and Lactoperoxidase Use: The Present Market 22Research Trends 23Communication towards the Consumers 24Frequently Asked Questions by the Industrial Users 24INTRODUCTION 30Lactoferrin and Lactoperoxidase: Two Bioactive Milk Proteins 30FUNCTIONALITIES 31LACTOFERRIN 31Heat stability 31Iron bioavailability 31Iron uptake from lactoferrin 32Cell proliferation 32Antimicrobial agent 32Antiviral agent 33Inflammatory and Immune response 33Anticancer activity 33Anti-oxidant effect 34Interaction of Lactoferrin with other molecules 34Receptor binding properties 34LACTOPEROXIDASE 35Microbiological Effect of the Lactoperoxidase 36Application of LPS in Food Industry 37Future Trends 38TRENDS OF RESEARCH 39PRODUCT POSITIONING 40PRODUCT RANGE 40Milk Proteins 40Competitive Products 41
Products involved in iron and calcium transport and absorption 41Casein phosphopeptide 41Ovotransferrin 42Iron salts 42Lactoperoxidase 42Lysozyme 42Other natural antibacterial agents 42APPLICATION RANGE 43LEGAL STATUS 44COMMUNICATION ABOUT THE PRODUCT 45PRICE 46SPECIFICATIONS 47EXTRACTING LACTOFERRIN 47FUTURE TRENDS 48COMPETITION 49PLAYERS AND THEIR STRATEGIES 49Producers 49ARMOR PROTÉINES SAS (FR) 51AGENNIX INC (US) 52AGRI MARK INC (US) 54FRIESLAND CAMPINA NV (NL) 56DSM FOOD SPECIALTIES BV (NL) 61ERIE FOODS INT’L INC (US) / MURRAY GOULBURN CO LTD (AU) 62FONTERRA CO-OPERATIVE GROUP LTD (NZ) 63GLANBIA NUTRITIONALS INC (US) / GLANBIA PLC (IE) 67INGREDIA SA – (FR) 70MILEI GMBH (DE) 73MORINAGA MILK INDUSTRY CO LTD (JP) 76MURRAY GOULBURN CO-OPERATIVE CO LTD (AU) 79PHARMING GROUP NV (NL) 81SYNLAIT (NZ) 85TARADON LABORATORY SPRL (BE) 88TATUA CO-OPERATIVE DAIRY CO LTD (NZ) 91TATURA MILK INDUSTRIES LTD (AU) 93VENTRIA BIOSCIENCE INC (US) 95
TABLE OF CONTENT
THE WORLD LACTOFERRIN AND LACTOPEROXIDASE MARKET
VITALUS NUTRITION INC (US) 96WESTLAND CO-OPERATIVE DAIRY CO LTD (NZ) 98WARRNAMBOOL CHEESE & BUTTER FACTORY CO.LTD (AUS) 101Industrial Production and Technologies 102Bovine lactoferrin and lactoperoxidase 102Human Lactoferrin 106Use of transgenic animal 106Fermentation using the fungus Aspergillus 106Patented Processes 107Process cost 107Processes description 109PROTECTED APPLICATIONS 110TRENDS 114MARKET ANALYSIS 115Lactoferrin Market 115Leading Applications 116Lactoferrin market by Application 119Lactoferrin market by Region 122Main suppliers of Lactoferrin 123LACTOFERRIN IMPORT CHINA 127FOOD APPLICATIONS 128Health food: Definition and Regulation 128General trends on the Health food markets 137Analysis by health food segments 141Infant Nutrition 142Regular Nutritional Food 152Nutritional drinks 152Mineral fortified food 155Functional Food 156Food Supplements 157Women's nutrition 161Senior diet 161Children diet 162Sport nutrition 162Weight management 164
Feed 165Preservatives in Food Products 166Trends on the market 166Perspective for lactoferrin and lactoperoxidase 166Company Advice and Profile 167ABBOTT LABORATORIES INC (US) 167ASHLAND INC (US) 170AVANTE INTERNATIONAL LTD (NZ) 172ZHEJIANG BEINGMATE SCIENTIFIC INDUSTRIAL TRADE SHARE CO LTD (CN) 174DICOFARM SPA (IT) 177GROUPE DANONE (NL) 178EAGLE ELECTRIC (Shenzhen) Co., Ltd (CH) 180GUANGDONG YASHILI GROUP CO LTD (CN) 181HEILONGJIANG YAOLAN DAIRY PRODUCTS STOCKS Co., Ltd (CN) 183HANS CORP CO LTD (KR) 185HOCHDORF NUTRICARE (CH) 188JIANGXI MEILU DAIRY CP LTD (CN) 189ANONYOUS CORPORATION (JP) 192WEIDER NUTRITION INTERNATIONAL INC (US) 194MAEL DAIRY INDUSTRY (KR) 196MEAD JOHNSON NUTRITION / MEAD JOHNSON & COMPANY LLC (US) 197MEIJI MILK PRODUCTS CO LTD (JP) 199MEGMILK SNOW BRAND CO LTD (JP) 201MORINAGA MILK INDUSTRY CO LTD (JP) 205MURRAY GOULBURN CO-OPERATIVE CO LTD (AUS) 208NESTLÉ SA (CH) 210NAMYANG DAIRY PRODUCTS CO LTD (KR) 212DANONE NUTRICIA ADVANCED MEDICAL NUTRITION (NL) 213NUTRIDAR PLC (JO) 214SEOUL DAIRY COOPERATUVE/ SEOUL MILK CO LTD (KR) 216OTSUKA PHARMACEUTICAL CO LTD (JP) 218LABORATORIOS ORDESA SL (SP) 219PT SARI HUSADA (INDONESIA) / GROUDE DANONE (FR) 222QUAKER (US) 224NESTLÉ PURINA PETCARE COMPANY (US) / NESTLÉ SA (CH) 226
TABLE OF CONTENT
THE WORLD LACTOFERRIN AND LACTOPEROXIDASE MARKET
REBORNNE NEW ZEALAND LTD (NZ) 227SCHIFF NUTRITION INTERNATIONAL INC (US) 228SHANGAI BRIGHT (GUANGMING) DAIRY & FOOD CO LTD (CN) 229SODIAAL SA (FR) 231SUNTORY HOLDINGS LTD (JP) 233UNITED DAIRY GROUP LTD (CN) 234WAKODO CO LTD (JP) 237INNER MONGOLIA YILI INDUSTRIAL GROUP CO LTD (CN) 238YABAIS DAIRY PRODUCTS CO LTD (AU) 240ZIM LABORATORIES LTD (IN) 244PHARMACEUTICAL APPLICATIONS 245Trends on the market 245Pharmaceutical drugs market 245Over the counter drugs market 245Cosmetic market 249Perspectives for lactoferrin and lactoperoxidase 251Immune system support 251Anti-infective 251Gastro-intestinal tract 251Ophtalmic products 252Anti-cancer therapeutic agent 252Product conservation 252Skin Health 253Anti-oxydant activity 253Lactoferrin Contraindications, Interactions & Precautions 254Company advices 255ALCON LABORATORIES (NOVARTIS GROUP-FR) 255BAUSCH & LOMB (US) 256PFIZER (ex JOUVEINAL - FR) 257LACLED INC (US) 258MERCK & CO (US) 260METAGENICS INC (US) 261MP BIOMEDICALS (US) 263NRL PHARMA INC (JP) 265OENOBIOL LABORATORIES (FR) 269
PIERRE FABRE SA (FR) 270PROHEALTH INC (CA) 271SYMBIOTICS INC / NATURADE INC (US) 274SOVEREIGN LABORATORIES INC (US) 275GROUPE GTF (FR) 278XIGO HEALTH LLC (US) 279ZENDIUM / UNILIVER NV (NL) 280ZIM LABORATORIES LTD (IN) 282LOVELY HEALTH LTD (NZ) 283FIT-BIOCEUTICALS LTD (AU) 284VIDA NUTRISCIENCE INC (PH) 286LIFE EXTENSION INC (US) 287GENOSCOPE SPZOO (PL) 288ANNEXES 289US PATENT 290Lactoferrin 290Lactoperoxidase 302REGULATION 319CFSAN/Office of Premarket Approval 319Data and information that DMV International presents to support its GRAS determination 319FDA's evaluation of the data and information in DMV International's notice 320Conclusions 321CFSAN/Office of Food Additive Safety 322REGULATION– NOVEL FOOD PETITION 325SPECIFICATIONS 329STUDIES 332CHINESE IMPORTATIONS OF LACTOFERRIN – LIST OF USERS / JAN-DEC 2012 336
LIST OF TABLES
THE WORLD LACTOFERRIN AND LACTOPEROXIDASE MARKET
Table 1 Lactoferrin market in tons estimations and forecast 1997-2015 12Table 2 Consumption of Lactoferrin by market segment 13Table 3 Lactoferrin potential market segment and main products 14Table 4 Present market of Lactoferrin market 22Table 5 Present market of Lactoperoxidase 23Table 6 Potentialities of Lactoferrin in Food Products 25Table 7 In OTC and Semi-ethical Drugs 26Table 8 In cosmetic and oral hygiene products 27Table 9 Potentialities of Lactoperoxidase In food products 28Table 10 In cosmetic and oral hygiene products 29Table 11 In OTC and semi-ethical drugs 29Table 12 Interaction of Other Molecules and Lactoferrin 34Table 13 Nutritional/biological function in Milk protein and Bioactive 40Table 14 Potential Application in Lactoferrin and Lactoperoxidase 43Table 15 Main suppliers of Lactoferrin 50Table 16 Extraction methods performed by different companies 105Table 17 Patented process in Lactoferrin Manufactures 107Table 18 Patented Lactoferrin Based Products and Applications 110Table 19 Patented Lactoperoxidase Based Products and Applications 113Table 20 Examples of LF application available in Japan 116Table 21 Lactoferrin market in tons estimations and forecast 1997-2015 118Table 22 Lactoferrin market Forecast in Infant Formula 2011-2015 (tons) 119Table 23 Lactoferrin market Forecast in Foods 2011-2015 (tons) 119Table 24 Lactoferrin market Forecast in Pharmaceuticals 2011-2015 (tons) 120Table 25 Lactoferrin market Forecast in Hygiene 2011-2015 (tons) 121Table 26 Consumption of Lactoferrin by market segment (ton) – 2014 122Table 27: Lactoferrin Import China 2012 127Table 28 Approved FDA health claims in specific cases (food and nutrition) 135Table 29 Nutraceuticals market in Japan (2011) 137Table 30 Health foods Category in Japan (2011) 138
Table 31 Global users of Lactoferrin in Infant Formula (2012) 149Table 32 Japanese users of Lactoferrin in Infant milk and formula milk (2013)151Table 33 Comparisons of Main Nutritional Formulas 153Table 34 Sales of Leading Functional Drinks in Japan 154Table 35 Other using segments for Lactoferrin - Functional Food 156Table 36 Ingredient nutrition example of Lactoferrin tablet in USA 157Table 37 Other using segments for Lactoferrin- Food Supplements 158Table 38 Other using segments for Lactoferrin 165Table 39 New Food Biopreservatives 166Table 40 OTC main categories in USA 247Table 41 Other using segments for Lactoferrin - Cosmetic 250Table 42 US PATENT of Lactoferrin 290Table 43 US PATENT of Lactoperoxidase 302
LIST OF FIGURES
THE WORLD LACTOFERRIN AND LACTOPEROXIDASE MARKET
Figure 1 Most Promising Segments of Development for Lactoferrin 16Figure 2 the World Lactoferrin Market by Shares of Producers (2015) 17Figure 3 Strategic Issues for Lactoferrin and Lactoperoxidase 20Figure 4 Strategic recommendations for using Lactoferrin 21Figure 5 Relative added value pyramid for protein derived from whey 46Figure 6 General extraction methods of Lactoferrin and Lactoperoxidase 102Figure 7: Lactoferrin’ global Market volume estimations (2007-2017) 115Figure 8: Lactoferrin market breakdown by application 2014 117Figure 9 Lactoferrin market Forecast in FOOD & NUTRITION (2015) 119Figure 10 Lactoferrin market Forecast in Pharmaceuticals (2015) 120Figure 11 Lactoferrin market Forecast in Pharmaceuticals (2015) 121Figure 12: Lactoferrin market breakdown by application 2014 121Figure 13: Lactoferrin market consumption by geographical area 2014 122Figure 14: Lactoferrin Import in China in volume by month 2012 127Figure 15: Country of origin of Lactoferrin imported (in kg) in China 2012 127Figure 16: Chinese Import of Lactoferrin from the EU - 2012 128Figure 17 Schematic Circuits for a Novel Food Dossier 130Figure 18 Schematic Circuits for a New Additive Dossier 131Figure 19. Health Foods without FOSHU (billion Yen) 1988-2011 137Figure 20. Market Scale of FOSHU in Japan (billion Yen) 1997-2011 138Figure 21. Annual trends in Number of Items of FOSHU (1993-2012) 139Figure 22. Percentage of the Products by Health Claim FOSHU (2011) 139Figure 23 History of Infant Formula’s product and modification 143Figure 24: Share Individual OTC market in Europe 247Figure 25: OTC Drug market size in Japan 2004-2013 248
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THE WORLD LACTOFERRIN AND LACTOPEROXIDASE MARKET
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