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School of Pharmacy and
Pharmaceutical Sciences: Research
Anne Marie Healy
Head of School
04/02/2015
Trinity College Dublin, The University of Dublin
Pharmacists Pharmaceutical Technologists
Pharmacologists
Pharmacognosists Pharmaceutical/Medicinal
Chemists Biotechnologists
Pharmacy Practitioners
MDs/Clinicians
Cancer
Research
Disease, Drug
Mechanisms & Safety
New Drugs: de novo
synthesis or from nature
Clinical Pharmacy
& Pharmacy Practice
Pharmaceutics &
Pharmaceutical Technology
R’BIRTH Brain Imaging Return to Health
Trinity College Dublin, The University of Dublin
De Novo Synthesis
» Design, synthesis and evaluation of molecular structures as
potential anti-cancer drugs
» Pro-drug optimisation of our current candidates
» Dual targeting drugs e.g. ER/aromatase, tubulin/aromatase
» Design of multi-drug resistance modulators
From Natural products
» Anti-cancer lead discovery from natural sources
» Ethno-medicine & evidence-based traditional Chinese
medicine
» Cross-hybridisation of natural molecules as anti-cancer
scaffolds
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OOH
HO
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OH
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New Drugs: de Novo Synthesis or from Natural Products
Trinity College Dublin, The University of Dublin
Disease, Drug Mechanism & Safety
Nanoparticle-platelet interaction (SEM) Nanoparticle-platelet interaction (AFM)
soluble & surface-bound nanoparticles
» Platelet pathology and pharmacology of anti-platelet drugs
» Nanopharmacology
» Nanotoxicology
» Pathophysiology and experimental therapeutics of inflammatory diseases
» Drug efficacy, toxicity & ADR evaluation
Trinity College Dublin, The University of Dublin
Cancer Research
» Target identification & validation
» Anti-cancer drug development
» Re-purposing “old” drugs
» Molecular mechanisms: cancer development & drug
resistance
» Diagnostic, prognostic & drug-companion biomarkers
» Exosomes & platelets in cancer angiogenesis, metastasis,
drug-resistance
» Nano-delivery of anti-cancer agents
» Pharmaco-kinetics & -dynamics of anti-cancer drugs
» Clinical trials design & development: Phase I & II
P=0.00000000000001
Time (month)
NmU(+)
NmU (-)
Pro
ba
bili
ty.
In Vivo
Studies
Pipeline drug evaluation:
anti-cancer potential
Some target discovery Phase I :
“Basic” in vitro
screening
+/-chemo
+/-targeted
Translational
Clinical
Trials
(Phase I&II)
Phase II
“Advanced”
In Vitro
Screening
Trinity College Dublin, The University of Dublin
Pharmaceutics & Pharmaceutical Technology
» Design, production and evaluation of advanced drug delivery
systems
» Optimisation of formulations for poorly soluble drugs
» Advancing conventional formulation & manufacturing of solid
dosage form medicinal products
» Nano-sized delivery systems for small and macro-molecules
» Pharmaceutical salts and cocrystals
» Formulation of lipid-based delivery systems
» Identification of absorption pathways
» Pulmonary drug delivery
» Drug disposition after pulmonary administration
» Drug-transporter interactions
» Dissolution testing and simulation
Molecule Material Medicine
Epithelial cells for drug absorption
studies
Particle engineering by spray drying
for pulmonary delivery
Trinity College Dublin, The University of Dublin
Clinical Pharmacy & Pharmacy Practice
» Clinical pharmacy & pharmaceutical care of vulnerable groups
» Pharmacy practice, medication use and patient safety
» Health services research & evidence-based practice
» Clinical pharmacokinetics-pharmacodynamic:
– patient- & disease - related effects on distribution/ elimination
» Pharmaco-epidemiology, pharmaco-economics & pharmaco-vigilance
» Healthcare law, regulation & professional ethics in pharmacy practice
» Educational research, workplace learning & technology-enhanced
learning
Optimise medication use
Pharmaceutical care for vulnerable patient
groups
Health Policy, Regulation &
Population health
Professional education &
training
Primary & secondary care pharmacy
Trinity College Dublin, The University of Dublin
TCD Graduate Studies
Postgraduate Scholarships
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