role(s) of interleukin 2 by shoba satkuru msc biomedical immunology
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Role(s) of Interleukin 2
By
Shoba Satkuru
MSc Biomedical Immunology
Properties of Interleukin 2
Source- Mainly by activated T-cells expressing CD4
surface Ag
Structure- 133 amino acids -15.4kDa in
weight
Genetic Structure Contains 4 exons Synthesis regulated at level of
transcription Receptors Mediated by membrane receptors 3 types: High Affinity
Intermediate Affinity Gamma Subunits
Biological Activities and Functions
Stimulates T cell proliferation Stimulates B cell growth/differentiation Generates Lymphokine activated killer cells
(LAK cells) Activates macrophages Stimulates T cells to produce other
cytokines Stimulates proliferation of oligodendrocytes
Clinical Use & Significance Transgenic animals, knock-out and
antisense studies Anti-tumor activity Adoptive Immunotherapy Treatment of cellular immunodeficiency
diseases
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