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Rhodium-Catalyzed C−H Functionalization and Seven-membered Ring Formation
Reporter: Dai Lu Supervisor: Prof. Zhao Jing Dr. Hong Mei
2013-12-23
Different Annulation Options for o-Vinylphenols
three different C−H positions
2-hydroxystyrene
chromene-type molecules
benzofuranes
Morimoto, K.; Hirano, K.; Satoh, T.; Miura, M. J. Org. Chem. 2011, 76, 9548−9551.
oxepines
A Formal (5 + 2) Cycloaddition Reaction
Scope with Respect to the Alkyne Component
Phenols Equipped with Different Substituents
Proposed Mechanistic Cycle
(4 + 3) Annulations
benzamide furan-2-carboxamide
spiro dihydroisoquinolinone furan-fused azepinone
Proposed mechanism
(4 + 3) Annulations
vinylcarbenoids
(4 + 3) Annulations Angew. Chem. Int. Ed. 2013, 52, 5393 –5397
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