reversing diabetes
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Consultant Obstetrician & Gynaecologist
M.B.B.S. (Madras), F.R.C.O.G (London) Board Certified Anti-Aging Physician
ABAARM & IHS
By Datuk Dr. Selvam RengasamyPresident, SAHAMM
(Society for Advancement of Hormonesand Healthy Aging Medicine, Malaysia)
SAHAMM ROADSHOW MALACCA , 15th June 2013
2Datuk Dr. Selvam Rengasamy
Society for Advancement of Hormones and Healthy Aging Medicine, Malaysia
(SAHAMM) website : www.sahamm.orgemail : sahamm020212sec@gmail.comTel : 03-62030190 / 016-3078074Fax : 603-62049223
3Datuk Dr. Selvam Rengasamy
Datuk Dr. Selvam Rengasamy
SPEAKERSDatuk Dr. Selvam
Dr. Karel Hromek
Prof. Mel Sydney Smith
Dr. Robyn Cosford
CPD Points: 10
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Datuk Dr. Selvam Rengasamy
Topics:Introduction to Nutritional Medicine
Nutritional Bio Chemistry
Diabesity
Cancer Causes & Nutritional Support
Children’s Health in the 21st Century
Pediatric Allergy
Injectable Nutrients
The Sensitive Patients
Skin Prick Testing with Practical Demonstrations5
Datuk Dr. Selvam Rengasamy
The SUPERIOR doctor prevents sickness;
The doctor attends to impending sickness;
The INFERIOR doctor treats actual sickness.
Chinese Proverb
6
7Datuk Dr. Selvam Rengasamy
High Blood Glucose
Insulin Excess / Insulin Resistance
Insulin Deficiency
But Treatment Is The Same !!!
DIABETES
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Datuk Dr. Selvam Rengasamy
INSULIN RESISTANCE
INSULIN RESISTANCE = PRE DIABETES
2.5% Increase In Type 1 Diabetes Annually
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Datuk Dr. Selvam Rengasamy
INCEDENCE OF HYPERINSULINEMIA
10
TEST INSULIN FASTING
SUGAR%
TOTAL TESTED 700 700 47
LEVELS > 11 uU/ml 331 247 35
2007 - 2009
Datuk Dr. Selvam Rengasamy
INCEDENCE OF HYPERINSULINEMIA
11
Test Yr 2010 Yr 2011 Yr 2012
TOTAL TESTED 468 533 496
LEVELS > 11 uU/ml 223 231 202
Datuk Dr. Selvam Rengasamy 12
0
100
200
300
400
500
600
Yr 2010 Yr 2011 Yr 2012
TOTAL TESTED
LEVELS > 11 uU/ml
HYPERINSULINEMIA & PRE - DIABETES
No Of Patients
020406080
100120140160180
10-20 21-30 31-40 41-50 51-60 61-70
Gt <5.2 Gt >5.2Is <11 Is >11
Datuk Dr. Selvam Rengasamy
GLUCOSE & INSULIN STUDY
* 2 Years Data
Age Group Gl <5.2 Gl >5.2 In <11 In >1110-20 11 8 9 10
21-30 172 25 117 80
31-40 152 80 127 105
41-50 78 67 66 79
51-60 36 45 39 42
61-70 4 22 11 15
Gl ≤5.2
In < 11
Gl >5.2
In > 11
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Datuk Dr. Selvam Rengasamy 14
Control Blood Sugar
Reduce Glycation - HbA1c Reduce Oxidative Stress
Controlling Blood Sugar only Does Not Reduce / Prevent Complications
DIABETES
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Datuk Dr. Selvam Rengasamy
Excess Sugar
Excess HbA1c
Rust In Your Body
SystemicOnce Formed - Permanent &
Cannot Be ReversedCannot Metabolized Or Eliminated( Until Death Of RBC’S )
HbA1c
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Datuk Dr. Selvam Rengasamy
INSULIN & HISTORY
1980’s - Insulin Resistance Recognized
AND DIABETES STILL REMAINS
IRREVERSIBLE !!!
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Datuk Dr. Selvam Rengasamy
Aging Increases Gluconeogenesis
- 3 Times More Gluconeogenesis In The Liver
HYPERGLYCEMIA
INSULIN DOES NOT DECREASE GLUCONEOGENESIS
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Datuk Dr. Selvam Rengasamy
Insulin Is Not The Best
Option For Type 2 Diabetes
with Insulin Resistance
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(HYPERINSULINEMIA)
Datuk Dr. Selvam Rengasamy
INSULIN
Storage Hormone - Fat Anabolic Hormone - Muscle Hypoglycemic Potassium, Magnesium &
Amino Acids into Cells
POTENT INFLAMMATORY HORMONE IN EXCESS !!!
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Datuk Dr. Selvam Rengasamy 22
Society for Advancement of Hormones and Healthy Aging Medicine, Malaysia (SAHAMM)
website : www.sahamm.orgemail : sahammsec@gmail.com Tel : 03 - 62030190 / 016 - 3078074Fax : 603 - 62061627
HYPERINSULINEMIA=
Insulin Resistance Metabolic Syndrome Syndrome X Cardio-metabolic Syndrome CHAOS
. . .more terms to come!!!23Datuk Dr. Selvam Rengasamy
Datuk Dr. Selvam Rengasamy
HYPERINSULINEMIA
A Severe Imbalance Of The Endocrine System - Destroy Our Ability To Metabolize Food
Balanced / Healthy Diet Replacing The Missing Essential Elements of
Nutrition - mostly MINERALSCorrecting Hormone Deficiencies
Exercise
Eliminating Toxins In Food Supply
24
HYPERINSULINEMIA
High Insulin = Chronic Silent Inflammation
CHRONIC DEGENERATIVE DISEASES
Datuk Dr. Selvam Rengasamy 25
Datuk Dr. Selvam Rengasamy
HYPERINSULINEMIA
CAN REMAIN ASYMTOMATIC FOR YEARS
NEED TO SCREEN AND TREAT THIS CONDITION
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Datuk Dr. Selvam Rengasamy
Weight Gain Sugar Cravings Intense Hunger Weakness , Fatique Need For Frequent Meals Poor Concentration , Memory Loss Emotional Instability - Anxiety Or
Panic Attacks
SYMPTOMS= HYPOGLYCEMIA
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Datuk Dr. Selvam Rengasamy
HYPERINSULINEMIA
FASTING INSULIN
> 11 uU / ml
HEALTHY LEVELS5 - 7 uU / ml
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Datuk Dr. Selvam Rengasamy
HYPERINSULINEMIA Fasting Glucose 3.5 - 4.8 mmol / L
BMI 25 or more
TGL > 1.68 mmol / L ( 150mg ) HDL < 1.53 (40mg) for men / > 1.93
(50mg ) for women BP > 130 / 85 mm / Hg Waist Circumference > 40 in (men)
& > 35 (women)
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Datuk Dr. Selvam Rengasamy
INSULININSULIN IN EXCESS
IS A DEATH HORMONE
Damages Vascular Endothelium
Promotes Atherosclerosis
Promotes Weight Gain
Promotes Cancer
“A SILENT KILLER”30
Datuk Dr. Selvam Rengasamy
Premature Aging
Insulin Resistance
Diabetes Mellitus
Metabolic Syndrome
Hypertension - Angiotensin
Clotting - PAI Complex
HYPERINSULINEMIA
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Datuk Dr. Selvam Rengasamy
HYPERINSULINEMIA
Chronic Degenerative Diseases
Heart Failure, Stroke, Kidney Failure, Impotence, Neuropathy, Retinopathy And A Host Of Other Diseases
Likely To Be Implicated, Very Closely in ADHD & ADD
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Datuk Dr. Selvam Rengasamy
HYPERINSULINEMIA
Hypertension
Central Obesity
Decreased HDL
Increased TGL
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Datuk Dr. Selvam Rengasamy
Hyperinsulinemia The Delta-desaturase Enzyme
Conversion Of Omega 6 Fatty Acid To Arachidonic Acid And PGE2
Chronic Silent Inflammation
HEART CONNECTION
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HEART CONNECTION
Datuk Dr. Selvam Rengasamy
“GOOD” Eicosanoids (EPA / DHA) Decrease Insulin
Inhibited By EPA
Effects Of Insulin On EFA Production
ActivatedBy Insulin
Delta 5 Desaturase
Omega 6 Fatty Acids
Arachidonic Acid
“Bad” Eicosanoids
Increase InsulinProduction
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Datuk Dr. Selvam Rengasamy
THROMBOXANE A2
HEART CONNECTIONARACHIDONIC ACID
(Inhibited By Eating Less Insulin-stimulating Carbohydrates, Meat And By Consuming More Cold-water Fish, Fish Oil And Sesame Lignans)
COX – 1(Inhibited By
Low-dose Aspirin)
COX – 2(Inhibited B y Celebrex, Curcumin, Resveratrol
And Green Tea)
5 - LIPOXYGENASE(Inhibited By Zyflo,
Curcumin And 5-LOXIN)
PROSTAGLANDIN E2 LEUKOTRIENE B4 5 - HETE
Abnormal Platelet
AggregationInflammation,
Atherosclerosis and Joint Destruction
Interferes With Cancer Cell Death (Apoptosis)
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Datuk Dr. Selvam Rengasamy
Hyperinsulinemia Leads To Visceral Fat
Inflammatory Cytokines ( TNF α , PAI Complex, Adiponectin e.t.c )
&Free Radicals
Interaction With TNF α Receptors
More Insulin Resistance
OBESITY / INFLAMMATION CONNECTION
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Datuk Dr. Selvam Rengasamy
Decreased IGF- 1 Premature Aging
Homocysteine
Leads To Mood And BehaviourDisturbances - Depression, Anxiety,Panic Attacks, ADHD e.t.c
HYPERINSULINEMIA
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Datuk Dr. Selvam Rengasamy
HYPERINSULINEMIA
Increased Uric AcidLevels
- Gouty ArthritisAcanthosis NigricansHaemochromatosis
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Datuk Dr. Selvam Rengasamy
HYPERINSULINEMIA
ISCHEMIC EVENTS
AN INCREASED SUSCEPTIBILITY TO INFECTIONS (Dental) & INFLAMMATION
INLAMMATION RECOGNISED BY IMMUNE SYSTEM
PATCHES UP THE DAMAGE WITH MACROPHAGES , PLATELETES , FIBRIN , Lip(a), CALCIUM E.T.C.
ATHEROMA
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More Inflammation
Leaky Gut Syndrome
Datuk Dr. Selvam Rengasamy
CANDIDA CONNECTION1. Intestinal Candidal Overgrowth
2. Increased AGE Products
Host Of Problems Like Multiple And Changing Food AllergiesUnexplained IllnessesFibromyalgia e.t.c.
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Datuk Dr. Selvam Rengasamy
IMMUNE CONNECTION
HyperinsulinemiaSuppresses Immune
System
ACTIVATES ONCOGENES
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Datuk Dr. Selvam Rengasamy
INSULIN & CANCER
Metformin Alone – Reduced CancersInsulin Alone - 80% Higher Risk of Cancer or CVD or
Death from any causeInsulin + Metformin – 31% Higher Risk of the above
Increases IGF-1 Receptors
Cell Proliferation
Increased Cancers esp. GIT & Pancreas
Ref: Cardic University 2000-2010 / 84622 Patients Clin Endocrinol Metab. 2013 Jan 31
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Temporary Glucose Intolerance in Pregnancy
- 7 Fold Increase in PancreaticCancer
Ref: SellaT, ChodickG, BarchanaM , et.al . Cancer Causes Control . 2011 Nov;22 (11:1513-20)
44Datuk Dr. Selvam Rengasamy
Gestational Diabetes & Cancer
Datuk Dr. Selvam Rengasamy
INSULIN & DHEA
DHEAAnti - DiabeticAnti - ObesityAnti - AtherogenicBoost Immune SystemLowers Cancer RiskAppetite SuppressantNeuro - Hormone
HYPERINSULINEMIA = LOW DHEA
Ref: Nestler J.E, Beer N.A, Jukubowicz D.J. J Clin Endocrinol Metab, 1994 Mar; 78(3):549 -554 Nestler J.E, CloreJ.N, Blackard W.G FASEB J, 1992, Sept; 6(12): 3073-75
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Datuk Dr. Selvam Rengasamy
INSULIN & MAGNESIUMInsulin Is Necessary For Mg Entry Into The Cells
HYPERINSULINEMIA = INCREASE URINARY LOSS
LOW SERUM MAGNESIUM
Hypertension / CVD Cardiac Arrhythmias Migraine, Cramps & etc. Low Thyroid Function PMS
More Than 300 Enzymatic Reactions Affected
Ref: Drug the Bull 1995; 33:25-7 Chen MD, Chew WH J Trace Elem Med Biol 2001;14:228-3146
Reduces Blood Pressure
Regulates Heart Rhythm
Improves Nerve Conduction
Reduces Tissue Edema
PMS CONNECTIONIncreased Blood Glucose
=Increase Insulin, Cortisol, Adrenaline And PRL
Datuk Dr. Selvam Rengasamy 48
Estrogen Dominance
Block Progesterone Activity
PCO CONNECTION
Increased Insulin =
Decreased Conversion Of Androstenedione To Estrogen
Datuk Dr. Selvam Rengasamy
Androgen Dominance
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CORTISOL - INSULIN CONNECTION
Datuk Dr. Selvam Rengasamy
Increased Cortisol
Increased Blood Glucose
Increased Insulin
Chronic Inflammation
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Datuk Dr. Selvam Rengasamy
HbA1cThe Rust In Your Body
Complex Molecule of Glucose and Protein
Once Formed, Is Permanent & Irreversible
Once Formed , Cannot Be Metabolized & Excreted Once Formed , Remains In The Body Until
Death of RBC’s
HbA1C IS INFLAMMATORY Affects All Cells
Optimum Level : < 5% 51
Datuk Dr. Selvam Rengasamy
ETIOLOGY
AGEINGPhysical Activity
Excess Caloric IntakeObesityInsulin ResistanceVitamin Deficiency ( Vitamins B & D )Cellular Mineral Deficiencye.g. Chromium, Magnesium, ZincManganese, Vanadium
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Datuk Dr. Selvam Rengasamy
Toxic OverloadGenetics
HYPER INSULINEMIA
RARE CAUSESInsulinomaExcess β Cells In ThePancreas
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WHEAT AND DIABETES
Datuk Dr. Selvam Rengasamy
GLUTENRaises Glucose Level Higher Than Sucrose ( Table Sugar )Acidic
Inflammatory
Triggers Autoimmune Reaction - Pancreatic Damage
Increases Visceral Fat Inflammation
Insulin Resistance
Diabetes
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Datuk Dr. Selvam Rengasamy
SUGAR
Inflammatory
Suppresses Immune System
Suppresses Hormones
Acidic
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Datuk Dr. Selvam Rengasamy
Artificial Sweeteners & Iron ( Lean Meat) increase Insulin Resistance
HYPER INSULINEMIA
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Ref: Corkey BE. Banting Lecture 2011. Diabetes . 2012 Jan; 61 (1):4-13
Poor Muscle Mass Central Obesity Insulin ResistanceDecrease Physical Performance Effects On Other Hormones
WATCH XENO – ESTROGENS !!!Datuk Dr. Selvam Rengasamy
HORMONES
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Testosterone & Diabetes
Moller from 1950 – 1984 treated > 10000 men & women with
Testosterone injections to treat D. M, Gangrene & Heart Disease
Ref: Oh JY, Barrett- Connor E et al. Diabetes Care 25:55-6058Datuk Dr. Selvam Rengasamy
Datuk Dr. Selvam Rengasamy
Decreases Fat Mass
Increases Muscle Mass
Improves OGTT Values
Improves Fasting and Postprandial Blood Sugar
Improves HbA1c
Reduces Diabetic Related Complications & Mortality
Increases Haemoglobin – Beneficial For Dialysis Patients
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Ref: Ding EL. Sex Differences of Exogenous Sex hormones and Risk of type II Diabetes.Journal of the American Medical Association 2006; 295:1288-1299Hayward RA, Maning WG, Kaplan SH, Wagner EH, Greenfield S. Starting insulin therapy in patients with type 2 diabetes: effectiveness, complications and resource utilization. JAMA. 1997; 278:663-69Gascan AM, Belvis JJ, et al. Nandrolone decanoate is a good alternative for the treatment of anemia in elderly male patients on hemodialysis. Geriatric Nephrology & Urology. 1999; 9(2):67-72
Testosterone Improves Insulin Sensitivity
Testosterone Increases - Glucose To Glycogen- Glycogen To Glucose
↓Prevents Hypoglycemia
60Datuk Dr. Selvam Rengasamy
Ref: Gascon AA. Nandrolone Decanoate is a good Alternative for the treatment of Anaemia in elderly male patients on Hemodialysis. Geriatric Nephrology and Urology. 1999; 9(2):67-72
Teruel JL, et al. Androgen versus erythropoietin for the treatment of anaemia in Hemodialyzed Patients: A prospective study. Journal American Society of Nephrology. 1996; 7(1):140-4
Average Increase in Muscle Mass - 1.2 kg
Average Decrease in Fat Mass - 1.5 kg
Exercise Induced Fat Loss Is Accelerated with Testosterone Therapy
Ref :
Bhasin S , Storer TW, Berman N, et al J. of Clin. Endocrinol. and Metabol 82: 407-13
Kupelinn V, Page ST, Aramijo AB, et al J. of Clin, Endocrinol, and Metabol 91:843-50
Wang C, Swerd Coff RS, Iranmanesh A, et al J. of Clin. Endocrinol and Metabol 85 (8):2839-53
6 MONTHS of TESTOSTERONE
61Datuk Dr. Selvam Rengasamy
TESTOSTERONE REFERENCES
Datuk Dr. Selvam Rengasamy 62
Kapoor D, Goodwin E, et al. Testosterone Replacement Therapy Improves Insulin Resistance, Glycemic Control, Visceral Adiposity & Hypercholesterolemia in Hypogonadal Men with Type 2 Diabetes. European Journal of Endocrinology. 2006; 154(6):899-906
American Diabetes Association. Type 2 Diabetes in Children and Adolescents. Diabetes Care. 2000; 3:381-389
Cohen PG. Diabetes mellitus is associated with subnormal levels of free testosterone in men. British Journal of Urology. 2006; 97(3):652-3
Small M, et al. Metabolic Effects of Stanzolol in type II Diabetes Mellitus. Hormones Metabolic Research. 1986; 18:647-8
DHEA & DIABETES“Disease Predicting Hormone ”
Main Actions:Increases Liver Glucose OxidationReduces Gluconeogenesis ( Glycogen to Glucose )Promotes Fat LossIncreases Muscle MassImproves Insulin Sensitivity Balance the effect of Cortisol on Fat Storage
Ref: Lardy H, Stratinan F, Elsevier N.Y, 1988;337-42Nestler JE, Clone JN, Blackard WG J Steroid Biochern Mol Vol. 1991;40(6):599-605Nestler JE, Mc Clanahan MA Ballieres Chin Endocrinol Metab, 1992 Oct: 6(4):829-47
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Datuk Dr. Selvam Rengasamy
DHEA & DIABETES
Increases Metabolism ( via Thyroid Function )
Reduces Complications of D.M & Islet Cell Exhaustion
Reduces Appetite
Inhibits Fat Synthesis and Storage
Ref: Cleary MP, Shepherd P, Jenits B, J Nutr. 1984;114:1242-51Coleman DL, Laiter EH, Applerweig N. Endocrinol 1984;115:239-43Kurtz BR, Givens JR et al. Chin Endocrinol Metab (64),1262-67
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DHEA & REVERSING DIABETES
Datuk Dr. Selvam Rengasamy
Low DHEA & Testosterone → High Insulin Levels
DHEA & Free Testosterone have Reverse correlation with Blood Glucose
DHEA & Free Testosterone improve InsulinSensitivity in Aging & Obese Patients
Reduces complications of D.M esp Atherosclerosis
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Ref: Heffner JE, Milain M, Ain J. Respir. Cell Mol (2)1990:257-61Buffington CK, Givens JR, Kitbachi AE Chin. Res (36), 1988:41Barrett – Corner E, Khaw T N. Eng. J. Med. (315), 1986;1519-1524
Datuk Dr. Selvam Rengasamy 66
Decreases Obesity
Increases Muscle Mass
Increases Physical Performance
Reduces Insulin Resistance
Effects On Other Hormones
Datuk Dr. Selvam Rengasamy
Increases Metabolism
Reduces Fat Mass
Improves Immune Function
THYROID
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In Most Cases It Is Curable Permanently, Quickly, Economically And Often Easily And By :Natural Means: L i t t le O r N o D e s ign e r
D ru gs A re N e e d e d
A Cure Will Effect Financially The Orthodox MedicalCommunity, The Drug Business And The Food Processing Industries
“ In A Time Of Universal Deceit, Telling The Truth Is A Revolutionary Act”
George Orwell
TREATMENT
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Datuk Dr. Selvam Rengasamy
Inhibit AmylaseImprove Insulin SensitivityReduce Insulin ResistanceInhibit Glucose - 6 - PhosphataseIncrease Leptin LevelsReduce Leptin resistanceCorrect Hormone Deficiencies Correct Mineral Deficiencies
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TREATMENT
Datuk Dr. Selvam Rengasamy
TREATMENT
DIET & ExerciseMaintain Healthy Weight
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Datuk Dr. Selvam Rengasamy
TREATMENT
- Chlorogenic Acid (Coffee Bean Extract)- White Kidney Bean Extract- Cinnamon- Brown Sea Weed- Fenugreek etc.
Fiber
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CHROMIUM
Datuk Dr. Selvam Rengasamy
Improves Carbohydrate Metabolism
Improves Insulin Sensitivity
Reduce Blood Sugar
Increases Insulin Receptors
Reduces Appetite (In Higher Doses)
Anti-oxidantDose : 500 - 1000 mg / day
Ref: Althuis MD, Jordon NE et al. Am J Clin Nutr 76(1)(2002:148-55)Amato P Morales AJ, Yen SS. J Gerontol A Biol Sci Med Sci 55(5)(2000:M260-3)Bahijri SM . Saudi Med J 21(1)(2000:45-50)Bagchi B, Stohs SJ , et al. Toxicology 180(1) (2002:5-22)
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ZINC
Datuk Dr. Selvam Rengasamy
Constituent of > 300 MetalloenzymesImproves Carbohydrate MetabolismImproves Insulin Sensitivity &Pancreatic Function Useful in Diabetic Leg UlcersAnti-oxidant - Improves Immune FunctionUseful in Both Type I & II DiabetesDiabetes Increases Urinary Loss of Zinc
Dose : 25 - 50 mg / dayRef: DiSilvestro RA. J Nutr 130.55 Suppl (2000:1509-115)
Illouz R et al. Biochem Biophys Res Commun 295.1(2002:102-6)Niewoehner CB et al. AM J Med 81.1(1986:63-8)Haeger K Lanner E. Vasa 3.1(1974:77-81) 73
Datuk Dr. Selvam Rengasamy
MAGNESIUM
Involved in > 300 Enzymatic Reactions
Improves Insulin Sensitivity
Improves Glucose MetabolismReduces Diabetic Complications e.g. CCF, IHD, Hypertension, Arrhythmias
Ref: Paulisso et al. AM J Clin Nutr 55.6 (1992: 1161-7)Rodriguez - Moran M , Guerrero Romero F. Diabetes Care 26.4(2003:1147-52)Rodriguez - Moran M , Guerrero Romero F. Acta Diabetol 39.4(2002:209-13)Frishman WH, Grattan JG, Mamtani R. Current Prob Cardiol 30.8(2005:383-459)Rasmussen HS et al. Arch Intern Med 148.2(1988:329-32)
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ADDITIONAL MINERALSFOR BETTER GLYCEMIC
CONTROL
VANADIUM
MANGANEESE
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TAURINE - THE WONDER AMINO ACID
Prevents & Treats ObesityReduces Blood Sugar Prevents Type II DiabetesPrevents & May Reverse Complication of
Diabetes - esp. Cardiovascular + Neuropathy,Retinopathy & Nephropathy
Ref: Zhang M, Bi LF Fang, JH, et al. Amino Acids. 2004 June ;26(3):267-71Tsuboyama – Kasaoka N, Shozawa C, et al . Endocrinol. 2006 July;141(7):3276-84Franconi Floizzo A, et al. Curr Opin Clin Nutr Metab Care. 2006 Jan; 9(1):32-6Kim KS , Ohda H, Kim Jy, et al. Exp Mol Med. 2012 Nov 30;44(11):665-73Tippia PS, Thliveris J, et al. Exp Clean Cardiol. 2011 Fall;16(3):e 17-22Lee F, Abatan OI. Neurobiol Dis. 2006 June ;22(3):669-76Yu X, Xu Z, Mi M, et al. Neurochem Res. 2008 Mar; 33(3):500-7
NIACIN (VIT. B3)
Datuk Dr. Selvam Rengasamy
Improves Insulin Secretion
Enhances Insulin Sensitivity
Good Results In Early Onset IDDMEffective In The Prevention of IDDM In Children with Islet Cell Antibodies
Dose : 2.5 mg / kg / dayRef: 32000 population based study in NZ
Bingley PJ, et al. Diabetologia 36, 675-676,1993Elliot Rb, Pilcher CC. Diabetes Res Clin Pract 14, S85, 1991Mandrup Paulsen T et al. Diabetes Metabol Rev 9, 295-309, 1993
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Avoid Hydrogenated Oils / Saturated Fats
Omega 3 Fatty AcidsVitamin D₃
REDUCING COMPLICATIONS
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Natural ANTI INFLAMMATORYAgents:
- Curcumin- Quercetin- Bromelain- Boswellia- Ginger
REDUCING COMPLICATIONS
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Datuk Dr. Selvam Rengasamy
Natural ANTI-GLYCATION Agents:
- Benfothiamine- Methylcobalamin- Carnosine- Alpha Lipoic Acid
REDUCING COMPLICATIONS
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Datuk Dr. Selvam Rengasamy
ANTI OXIDANTS - Vit , C, E, D & A- CoQ10- Bio-Flavanoids- Carotenoids
REDUCING COMPLICATIONS
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HORMONES
TestosteroneDHEAThyroid Hormones Growth Hormones
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METFORMIN39 % Reduction In M.I36 % Reduction In Death From Any Cause62 % Reduction In Pancreatic CancerKills Cancer Stem Cells
NO INCREASE IN LACTIC ACIDOSIS
Ref: Hirsch HA, Lliopoulos D, Struhl K. Proc Natl Acad Sci USA. 2013 Jan 15:110(3):972-7
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Decrease Gluconegenesis ( Insulin Has No Such Action)Increase Insulin SensitivityDecrease Sr. Insulin LevelsDecrease TGLDecrease HbA1cActivates AMPK - Insulin Signaling
- Metabolism Of Glucose And Fats
Both Chlorogenic Acid And Curcumin Has The Same Beneficial Effects
METFORMIN
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Datuk Dr. Selvam Rengasamy
METFORMIN• DECREASE GLUCONEOGENESIS• INCREASE INSULIN SENSITIVITY• DECREASE SERUM INSULIN LEVELS • ACTIVATES AMPK - INSULIN SIGNALING
- METABOLISM OF GLUCOSE & FATS• DECREASE TGL• DECREASE HbA1c
METFORMIN - SIDE EFFFECTS
B12 Deficiencies - Increase Homocysteine- B12 & Folic Acid
Decrease Total & Free Testosterone?
Sulphonylureas - Increase Weight Gain- Increase CVD
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REFERENCESJung JW, Park SB, Lee SJ, Seo MS - PLoS 1. 2011; 6 (11:e), 28068
Hardy TM, Tollefsbol TO - Epigenomics. 2011 Aug; 3(4): 503-18
Bachmeier BE, Mohrenz IV - Carcinogenesis. 2008 Apr ; 29 (4): 779-89
Soerjomataram I, de Vries E, Pukkala E – Int J Cancer 2007 Mar 15; 120 (6: 1336-43)
Proceedings of Am. Coll. Of Endocrin. Insulin Resis. Aug 25-26, 2002
Endocr. Pract, 2003 Sep-Oct; 9 Suppl 2:22-112
Howard, G., etal. Circulation, 1996 May 15;93(10):1809-17
Duvnjak, L. and Duvnjak, M.J Physiol Pharmacol, 2009 Dec,:60 Suppl 7:19-24
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REFERENCES
Endemann, D.H. and Schiffrin, E.L. J Mam Soc Nephrol, 2004 Aug; 15(8):1983-92
Hemkens, L.G., etal. Diabetologia, 2009 Sep; 52(9):1732-44
Samy, N., etal. Dis Markers, 2009:26(4):163-70
deKort, S., etal. Leaky Gut Obes Rev, 2011 Jun;12(6):449-58
Schrijvers, E.M., et al. Neurology, 2010 Nov 30;75(22):1982-7
McGeer, E.G. and McGeer, P.L. J Alzheimers Dis. 2010;19(1):355-61
Matsuzaky, T., et al. Neurology, 2010 Aug 31;75(9):764-70
de la Monte, S.M. and Wands, J.R. J Diabetes Sci Technol, 2008 Nov;2(6): 1101-13
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TREATMENT Calorie Restriction Prolongs Life – 60% SIRT – 1 Gene Activation Delays Neuro-degeneration
Datuk Dr. Selvam Rengasamy
You’re only as good as your last meal !!!
Ref: Tsai LH. J of Neurosience May 22, 2013
88
HIGH FRUCTOSE CORN SYRUP
Promotes Obesity More Readily Than Regular Sugar
Increases Appetite (Central Action)
More Addictive Than Cocaine
D.M
C.S.I
Datuk Dr. Selvam Rengasamy
This Sugar Cannot Be Used By Muscles For Energy Production Shunt To Liver - Non Alcoholic
Fatty Liver 89
Datuk Dr. Selvam Rengasamy1800 10 20 30 6050 7040 19009080 2010 4030 6050 8070 10200090
RISE IN SUGAR CONSUMPTION 1800 - 2008Su
gar C
onsu
mpt
ion
in p
ound
s pe
r per
son
per y
ear
World War
I1815
1895
19141939
19551970
World War
II
Years 90
OUR CHILDRENDo We Need To Screen Their
Fasting Insulin Levels ?
Datuk Dr. Selvam Rengasamy 91
Datuk Dr. Selvam Rengasamy
MILK TOXIN!!!!!
Bovine Albumin Peptide -β Cell Antibodies
Ref: Gerstein HC. Diabetes Care 17, 13-19, 199492
HYPERINSULINEMIC DIET
Datuk Dr. Selvam Rengasamy 93
Datuk Dr. Selvam Rengasamy
CF
P
Longevity Diet
94
Datuk Dr. Selvam Rengasamy
HOMO VITRUVIAN- Da Vinci
HOMO FATRUVIAN
95
Datuk Dr. Selvam Rengasamy
HYPERINSULINEMIA1. have sugar / carbohydrate cravings
2. Eating Carbohydrates gives me temporary boost / energy and mood. I later crash.
3. I get irritable, tired, anxious and get headaches intermittently butfeel better after meals
4. I feel shaky 2 to 3 hours after a meal
5. I have a family history of Diabetes, Hypoglycemia
6. I have difficulty in loosing weight
7. I feel weak, tired and irritable if I miss a meal
8. I feel sleepy, dull and feel “drugged” after eating a meal full of pasta, bread, potatoes, rice, desert but feel better after a protein meal
9. I get palpitation after eating sweets
10.I get panic attacks in the afternoon If I skip breakfast
Yes NoQUESTIONAIRE
96
Datuk Dr. Selvam Rengasamy
11. My memory is poor
12. I get night sweats
13. I am tired most of the time
14. My waist – to – Hip ratio is > 0.8
15. I have polycystic ovaries
16. I have irregular menses / infertility
17. I have facial hair (for women only)
18. I have Heart disease
19. I have Diabetes Mellitus
20. I have recurrent fungal infections (vaginal candidiasis, jock itch)
If your score is > 7, you are likely to have Hyperinsulinemia / Insulin Resistance
QUESTIONAIRE Yes No
97
THANK YOU….For learning Medicine that
HEALS and be
HEALERS
98Datuk Dr. Selvam Rengasamy
HYPERINSULINEMIA ON YOUR BRAIN, YOUR BODY AND YOUR HEALTH
Thrombosis
Sti. Growth of Cancer Cells
Inflammation & Oxi. Stress
Homocystine By B6 & Folate
-Affects Methylation Cycle (Broken Brain)
Infertility & Hirsutism
Datuk Dr. Selvam Rengasamy
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