restorative benefit of exercise on affective disorders affective disorder exercisebdnf5-ht1a
Post on 29-Dec-2015
217 Views
Preview:
TRANSCRIPT
Restorative Benefit Restorative Benefit
of Exercise on of Exercise on Affective DisordersAffective Disorders
Affective DisorderAffective DisorderExerciseExerciseBDNFBDNF
5-HT1A5-HT1A
Affective DisordersAffective Disorders
Depression has a prevalence ranging from 5% to 20%
Current drug treatments are costly, only partly effective and present side-effects limit their therapeutic potential
ExerciseExercise
Exercise increases BDNF in the hippocampus BDNF influences serotonergic system Serotonergic system is intimately linked to depression 5-HT1A receptors are reduced in depressed patients
ObjectivesObjectivesDepressed patientDepressed patient
ExerciseExercise
NeurotrophinsNeurotrophins Serotonergic systemSerotonergic system ??
ImprovementImprovement
MethodsMethods Animal model (Wistar Animal model (Wistar
rats): rats): ExerciseExercise Antidepressant Antidepressant
administrationadministration Biochemical analysis Biochemical analysis Local infusion of TrkB Local infusion of TrkB
receptor blockerreceptor blocker Social defeatSocial defeat Behavioral testsBehavioral tests
Healthy volunteers:Healthy volunteers: Physical and psychological Physical and psychological
evaluationevaluation Aerobic exercise Aerobic exercise PET PET
Experimental ProtocolExperimental Protocol Animal modelAnimal model
Exercise SSRI
treatmentControl
WP1
0 week 3 weeks
BDNF levels in the hippocampusin situ hybridization and western blot
5-HT1A receptor levels in the hippocampusin situ hybridization, IHC and autoradiographic ligand binding
Experimental ProtocolExperimental Protocol Animal modelAnimal model
Exercise SSRI
treatmentControl
WP2
0 week 3 weeks
5-HT1A receptor levels in the hippocampusin situ hybridization, IHC and autoradiographic ligand binding
Intrahippocampal TrkB blocker infusion
Experimental ProtocolExperimental Protocol Animal modelAnimal model
Exercise SSRI
treatmentControl
WP3
Depressive-like behaviorssucrose preference test and Forced Swim Test
0 week 3 weeks1 week 2 weeks
Socially Defeated AnimalModel of depression
BDNF and 5-HT1A receptor levels in the hippocampusin situ hybridization, western blot, IHC and autoradiographic ligand binding
Experimental ProtocolExperimental Protocol Healthy VolunteersHealthy Volunteers
WP4
Physical and Psychological evaluationQuality of life questionnaires: Beck Depression Inventory, Zung Self-rating Depression Scale
5-HT1A receptor levels in the brainPET using [11C]WAY-100635
0 month 12 months6 months
Exercise ADIDASADIDAS
ADIDASADIDAS
Innovative Elements Innovative Elements
Validation of an alternative, cost-Validation of an alternative, cost-
effective therapeutic treatment effective therapeutic treatment
for a major health and for a major health and
socioeconomic burdensocioeconomic burden The proposedThe proposed research extends research extends
from an animal model (from an animal model (benchbench) to ) to
human subjects (human subjects (proof of proof of
principleprinciple))
International Consortium International Consortium
Anima Sana in Corpore Anima Sana in Corpore Sano Sano
WP4WP4
WP4WP4
WP3WP3WP3WP3WP3WP3WP1WP1WP1WP1
WP1WP1WP2WP2
ELENI ELENI WP2WP2
top related