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Scientific Council SC/53/9 Rev.1 Fifty-third Session 19/01/2017 Lyon, 25–27 January 2017 Auditorium
PROPOSED PROGRAMME AND BUDGET 2018–2019
(Revision 1)
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TABLE OF CONTENTS
1. INTRODUCTION 1
2. THE IARC PROGRAMME 2018–2019 5
Objective 1 Describe the occurrence of cancer 5
Objective 2 Understand the causes of cancer 6
Objective 3 Evaluate and implement cancer prevention and control strategies 8
Objective 4 Increase the capacity for cancer research 9
Objective 5 Provide strategic leadership and enhance the impact of the Agency’s contribution to global cancer research 11
Objective 6 Enable and support the efficient conduct and coordination of research 13
3. PROPOSED BUDGET 2018–2019 14
3.1 Explanation of the proposed regular budget 14
3.2 Financing of the regular budget 16
3.3 Extrabudgetary resources 17
4. BUDGET TABLES 21
A Proposed regular budget for the biennium 2018–2019 23
B Summary of biennial resources by level 2/3 objectives and sources of fund 24
C Summary of regular budget by level 2/3 objectives and year 25
D Summary of regular budget funded staff by level 2/3 objectives and staff category 26
E Analysis of staffing and resources by level 2/3 objectives 27
F Summary of budget changes from previous biennial budget 28
G Summary of regular budget by component and cause of increase/decrease 29
H Summary of regular budget and proposed financing 30
I Summary of proposed financing from assessments on Participating States and Governing Council Special Fund 31
ANNEXES 33
Information Table A Total staff and non-staff budget by Section and Group 35
Information Table B United Nations accounting rates of exchange: euros to US dollars 36
Information Table C IARC Project Tree structure and associated projects 37
Information Table D Group classification of countries and assigning units for assessed contributions 39
Information Table E Comparison of assessments on Participating States based on current and revised scales 40
Information Table F Comparison of proposed regular budget 2018–2019 with approved regular budget 2016–2017 by level 2/3 objectives 41
Information Table G Priority projects requiring additional voluntary contributions 42
Scientific Council SC/53/9 Rev.1 Proposed Programme and Budget 2018–2019 (Revision 1) Page 1 1. INTRODUCTION
The Proposed Programme and Budget 2018–2019 reflects the priorities set out in the IARC Medium-Term Strategy 2016–2020 (MTS) (GC/57/7) adopted by the Governing Council (resolution GC/57/R8). As with the previous Programme and Budget, the present document is structured according to the ‘IARC Project Tree’ (Information Table C), a framework showing how IARC’s activities at project level contribute to achieving the strategic goals defined in the MTS.
The use of a common integrated structure to present strategy, programme and budget permits a clear understanding of how IARC’s strategic priorities are being addressed, of the relative balance between different areas of activity, and of the corresponding decisions in terms of resource allocation.
Based on the priority objectives set out in the IARC Project Tree the work of the Agency is centred on six core areas:
1 - Describe the occurrence of cancer 2 - Understand the causes of cancer 3 - Evaluate and implement cancer prevention and control strategies 4 - Increase the capacity for cancer research 5 - Provide strategic leadership and enhance the impact of the Agency’s contribution to global
cancer research 6 - Enable and support the efficient conduct and coordination of research
The details of the strategy and activities in these priority areas for each of the IARC Sections and Groups is set out in the MTS and its associated Implementation Plans, respectively. In the following sections, the main objectives of the programme are outlined for each of the six core areas, which involve projects led by different Sections and Groups. The objectives, activities and budget of each individual project were defined in Project and Budget Proposal Sheets, submitted to review by the Scientific Council, which were mapped to the Project Tree structure. Resource allocations are presented at level 2 and 3 objectives of the Project Tree, thus permitting comparisons with the previous biennial budget 2016–2017 (Information Table F).
IARC appreciates the challenges faced by individual Participating States in approving the assessed contributions comprising the regular budget. The Agency has therefore prepared the proposed Programme and Budget 2018–2019 with a view to maintaining the same level of programmatic activity as in 2016–2017, with minimal change in the number of staff. Nevertheless, in order to meet evolving needs, the proposal reflects the abolition of some Sections and Groups as well as restructuring across a number of areas. This has necessitated considerable change management within a dynamic environment of both increasing opportunities and resource constraints. The impacts of these decisions on the budget are highlighted in the current document under each of the six priority objectives of the Project Tree.
The successful implementation of the IARC MTS can be achieved only through an integrated budget which complements the regular budget with extrabudgetary funds coming from competitive grant applications and a variety of other sources. The balance between these different funding sources is described briefly below.
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Over the last decade (2008–2009 onwards), staff costs - mainly statutory - have increased by close to €10 million, a 40% rise (Figure 1). Over the same period, the Governing Council has adopted an approach of zero nominal growth in assessed contributions from existing Participating States. However, to offset the major increase in staff costs, the Governing Council has agreed to increase biennial budgets through the assessed contributions from new Participating States joining IARC and, in the last three biennia, also through the use of supplementary funds from the Governing Council Special Fund (GCSF) (Figure 2).
Figure 1: Staff budget, non-staff budget, and number of posts
Figure 2: Approved regular budget 2008–2017 and proposed budget 2018–2019
Scientific Council SC/53/9 Rev.1 Proposed Programme and Budget 2018–2019 (Revision 1) Page 3 To further offset the rising staff costs, the non-staff budget has also been reduced, remaining €2.1 million lower in absolute terms in the Proposed Programme and Budget 2018–2019 than in 2010–2011 (Figure 1). The proportion of regular budget allocated to general management and administrative services has also been decreasing since 2010. This is largely the result of a sustained and carefully balanced effort to further improve the efficiency of services, while aiming to prioritize investment in the scientific programme.
The above approach to maintaining programmatic activity consistent with successful delivery of the IARC MTS presents some risks. First, there is an expectation from new Participating States of an increased scope in the Agency’s programme which must be managed without an increase in resources in real-terms. Indeed, expectation is also widespread among many additional stakeholders as the global importance of cancer within the broader noncommunicable disease agenda becomes increasingly clear. Second, the reliance on GCSF to fund the regular budget (€1.0 million in 2012–2013 and €0.5 million in each of the two subsequent biennia) is unlikely to be sustainable, particularly given the demands over the last decade on the GCSF to fund core elements of infrastructure, including laboratory equipment, biobank facilities and computing software and hardware as well as required improvements in security measures. This approach relies on continued income to the GCSF that is not secured. Notably there is a forecasted drop in income over the next biennium because of the completion of the 10-year period of payment of arrears from the Russian Federation. The additional sum currently funded from GCSF for the 2016–2017 biennium represents an average of €20 000 per Participating State. In this light, the Secretariat proposes the 2018–2019 regular budget to be financed only by assessed contributions from Participating States.
To ensure achievement of the required level of programmatic activity, the Agency has financed an increasing number of staff positions from alternative sources (Figure 3). Notably an increased number of posts have been financed from Programme Support Costs (PSC) generated from overheads on research grants, from GCSF generated from sales of publications, or from unbudgeted assessments from new Participating States (UB). At the time of preparation of the proposed Programme and Budget 2018–2019, 11.8 posts are anticipated to be financed from PSC in 2018–2019, 8 posts from GCSF and 5 posts from UB (Figure 3).
Figure 3: Number of posts funded from PSC, GCSF and UB in 2010–2019
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The PSC is used for positions in the Section of Support to Research (including in finance, procurement, IT and HR). The GCSF is used mainly for positions to ensure IARC publications, including in the Monographs Section (a pathologist, project assistant, clerks for production of the WHO Classification of Tumours series) and the Communications Group (publishing assistant, editor, web design, and social media). In contrast, the UB are used to support key scientific areas, prioritized in response to Scientific Council reviews (e.g. bioinformatics). Some of the support posts financed on PSC would be reduced if the scale of activity based on voluntary contributions from research grants were to drop. However, it is noteworthy that a number of essential positions are funded outside of the regular budget including a finance assistant, a budget assistant, IT helpdesk, and central secretarial pool.
The Agency has been successful in generating voluntary contributions to complement and build upon the platform provided by the regular budget, using the former funds to support an increased number of research posts (Professional and General Service). The extrabudgetary funds already secured for the 2018–2019 period are included in the integrated budget shown in budget tables; it is a signal of the strong performance of the Agency that the extrabudgetary resources secured at the time of preparing the previous Programme and Budget 2016–2017 were €8.2 million, compared to €16.4 million at the time of the current planning for 2018–2019, i.e. an additional €8.2 million or 100% increase across the two biennia.
As a new feature in the presentation of the Proposed Programme and Budget 2018–2019, the Agency has identified a number of discrete high priority projects for which extrabudgetary resources have not yet been secured. These projects will be the focus of specific resource mobilization efforts. The projects are detailed in the Information Table G and are presented to permit individual Participating States to consider making additional voluntary or in-kind contributions targeted to these project areas.
In summary, the Secretariat will continue to use all available resource streams to deliver the Programme and thus to fulfil the MTS. In line with the principles of maintaining the same level of programmatic activity, of minimal change to staffing levels and ceasing the reliance on the GCSF, the overall level of the proposed regular budget from assessed contributions, total €45.07 million, is based on the approved budget figures for 2016–2017 supplemented with the full contribution from Morocco plus an increase of just under €0.9 million in assessed contributions from the other 24 Participating States (an increase of 2.09%). This proposed budget represents a 3.82% increase from the approved 2016–2017 biennial budget. A combination of this regular budget and anticipated voluntary contributions will enable the continued successful delivery of the IARC MTS 2016–2020.
Scientific Council SC/53/9 Rev.1 Proposed Programme and Budget 2018–2019 (Revision 1) Page 5 2. THE IARC PROGRAMME 2018–2019
Objective 1 - Describe the occurrence of cancer
Monitoring global cancer occurrence, provision of accurate and timely statistics at national, regional and global level, and descriptive epidemiology remain core activities. Reliable cancer statistics are an essential component of effective cancer control programming, through identifying priorities for action and subsequently providing data for monitoring and evaluation of specific interventions. Recognizing the context of cancer within the broader noncommunicable disease (NCD) agenda, the Agency is also assessing the cancer burden relative to other NCDs, with expansion into new areas of expertise, notably demography (for gains in life expectancy), and economics (in relation to costs due to lost productivity).
Research in this area focusses on novel analyses of geographical, temporal and socioeconomic cancer patterns, highlighting the changing profiles and scale of cancer burden worldwide. The Agency does not only collate and analyse cancer statistics but also works alongside colleagues in cancer registries nationally to improve the quality and coverage of cancer registration worldwide.
Improved access to these data, in the sense of shared “public goods”, has driven the development of the new IARC Global Cancer Observatory, which encompasses available data on cancer burden in adults and children as well as on cancer risk factors and their impact by country worldwide.
Another important activity under this objective is production of the ‘WHO Classification of Tumours’ series, representing the consensus on tumour classification among international experts in cancer pathology. The revisions of the so-called “Blue Books” incorporate new disease entities and represent the international reference in human tumour classification. This is an essential provision for cancer surveillance, for epidemiological research and more broadly for the effective clinical management of cancer.
The main objectives in this area from the IARC Project Tree are therefore:
a. to improve and expand the reporting of descriptive cancer statistics;
b. to support improved coverage and quality of cancer registration, particularly in low- and middle-income countries (LMIC);
c. to improve tumour classification to inform cancer registration, research and treatment.
The Section of Cancer Surveillance (CSU) has a primary focus on this objective, with further contributions from the Sections of Nutrition and Metabolism (NME), Infections (INF) and Early Detection and Prevention (EDP). The Blue Books Group (BLB) within the Section of IARC Monographs (IMO) is responsible for the publications on tumour classification.
The overall resource level attributed to areas (a) and (b) above has been slightly increased from the 2016–2017 budget. However, within this largely unchanged overall budget there has been additional restructuring in response to the changing demands on CSU, notably the need to effectively manage additional personnel funded by extrabudgetary funds, for example in the context of the Global Initiative on Cancer Registration (GICR).
A significant reorganization occurred in area (c). The Molecular Pathology (MPA) Section had responsibility for the WHO Classification of Tumours project in addition to conducting a research
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programme on brain cancer. With the retirement of the Section Head a decision was taken to abolish the Section to permit two major changes: first, to consolidate laboratory research into fewer Groups/Sections, and second, to integrate the WHO Classification of Tumours project with the IARC Monographs and IARC Handbooks of Cancer Prevention in one Section. In addition to placing scientific and support staff in the same IMO Section, other personnel involved in the publishing process (notably editing and layout) from both MPA and IMO have been transferred into an expanded Communications Group (COM) to achieve efficiencies and economies of scale.
This major restructuring enhances scientific synergies across these three flagship publications, supports the adoption of best practices in expert evaluation and publishing processes and will yield economies of scale. In addition, the abolition of one research Section is a necessary response to the budgetary constraints faced by the Agency, permitting the non-staff budget to be maintained across the remaining Sections and some reinvestment in specific priority areas (e.g. bioinformatics). The Agency will be comprised of eight rather than nine research Sections.
The assignment of the Head, BLB full-time to the WHO Classification of Tumours project, together with reallocation of some additional support staff, has led to an increase in resources assigned to area (c). The combination of the above-mentioned changes across Objective 1 has led to a small increase in the overall proportion of the regular budget assigned to this area from 7.30% to 7.78%.
Objective 2 - Understand the causes of cancer
The causes of a significant proportion of common human cancers remain unknown. Research into preventive interventions requires an understanding of underlying etiology. Therefore a significant effort continues to be placed by the Agency on studying the interaction between environmental, lifestyle and genetic factors on the development of human cancers, drawing on unique opportunities for collaborative work worldwide.
Emphasis is placed on cancers of importance in LMICs and on interdisciplinary research. An interdisciplinary approach allows vital mechanistic insights into the biological plausibility of risk-factor/disease associations from epidemiologic studies, and the development and validation of new biomarkers for exposure assessment, susceptibility, early detection and prognosis of cancer. The knowledge gained through research on cancer causes is a foundation to investigation of strategies for cancer prevention and early detection, as addressed in Objective 3.
In addition to original research in this area, the Agency conducts international expert evaluations of the published scientific evidence on the carcinogenicity of potential risk factors. The IARC Monographs programme is widely regarded as the international reference in cancer hazard identification, used extensively by national and international risk assessment agencies to develop policies for cancer prevention by reducing exposure to known and suspected carcinogens. Dissemination of findings will be further enhanced with the development of a user-friendly and searchable internet database of Monographs, interlinked with other databases hosted at IARC (e.g. WHO ‘Blue Books’, Global Cancer Observatory, Handbooks of Cancer Prevention) and externally (e.g. ICD-11, PubChem).
Scientific Council SC/53/9 Rev.1 Proposed Programme and Budget 2018–2019 (Revision 1) Page 7 Major contributions to Objective 2 are made by INF, NME, IMO, Environment and Radiation (ENV), Genetics (GEN) and Mechanisms of Carcinogenesis (MCA) Sections, with further contributions from CSU. Specifically, CSU collaborates with different Sections to combine information on risk factors and cancer burden in order to provide global, regional or national estimates of the Population Attributable Fraction of cancers associated with a specific exposure. Such estimates are a further valuable support to cancer control planning worldwide.
The aims of the three broad categories of projects in this area are therefore:
a. to elucidate the contribution of different risk factors to cancer causation, through the conduct of epidemiologic studies;
b. to characterize the cellular and molecular changes induced by cancer risk factors, elucidating the underlying mechanisms of carcinogenesis and providing biomarkers for application to epidemiologic studies;
c. to provide authoritative, independent evaluations of the carcinogenic potential of environmental, lifestyle, and occupational factors of public health importance.
This area continues to represent a major focus for IARC with 26.34% of the overall budget, including a majority of the laboratory-based research. Within this overall figure there are, however, noteworthy trends and changes. The allocation to Objective 2 has decreased from 30.38% in 2014–2015 to the current level for 2018–2019, representing a reduction of around €1.3 million in absolute terms over three successive budget periods. This reflects the change in balance between the continued need for research on causes, under Objective 2, and for research more immediately relevant to policy application, conducted under Objectives 1 and 3.
In this context there has been recognition by IARC’s governing bodies of the importance of providing regular budget support to the Monographs (area (c) above) in order to reduce the risks related to heavy reliance on extrabudgetary resources. The modest increase in personnel assigned to the Monographs in the 2016–2017 regular budget has been complemented in the current proposed budget 2018–2019 by an additional €123 000 in non-pay budget. Without these changes to area (c) the decrease in the overall budget assignment to Objective 2 would have been greater.
The interdisciplinary work on cancer causation increasingly draws on large complex datasets with demands in terms of both biostatistics and bioinformatics. Bioinformatics has been highlighted by the Scientific Council, successive Peer Review Panels and by the Governing Council in May 2016 as an area where the Agency needs to ensure sufficient resources for its evolving programme, both in personnel and high performance computing (HPC) and data storage capacity. The Agency has made additional resources available in a combination of ways. First, a reduction in secretarial support to the MCA Section and discontinuation of the MPA Section has permitted creation of a new support post in bioinformatics (MCA) and a new computational biologist scientist post (Biomarkers Group, BMA). Second, additional required posts in bioinformatics have been funded through use of UB. Third, existing staff have changed duties to encompass bioinformatics activities. Fourth, a full review of computing needs has led to a proposal to the Governing Council for use of GCSF to finance the expanded HPC and data storage requirements.
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Thus the above changes in bioinformatics capacity have been achieved within the overall stable level of staffing on the regular budget, by restructuring, reassignments and strategic investment of alternative funding sources.
Objective 3 - Evaluate and implement cancer prevention and control strategies
The focus on “cancer research for cancer prevention” runs throughout all the Agency’s research areas, but is most directly evidenced by studies evaluating interventions for prevention and early detection of cancers, and research on their effective implementation. Indeed the Agency has major opportunities to work in close cooperation with national programmes in order to assess the factors which help or hinder the implementation of cancer control measures and to evaluate their impact on cancer burden. Thus research has been extended to encompass a broader commitment to studies at a programmatic level within the context of health service provision.
Research on preventive interventions includes strategies for prevention and early detection of cancers with a high burden in LMICs, from trials of vaccines against hepatitis B virus (HBV) or human papillomavirus (HPV), or on the eradication of Helicobacter pylori (H. pylori), through to studies evaluating simple and affordable screening methods and new technologies for cervical, breast, colorectal and oral cancer.
Implementation research involves the study of operational, cultural and socioeconomic factors affecting the successful implementation and scale-up of interventions for prevention and early detection of cancer in routine health services at national or regional level. The work on prevention has also expanded to consider the factors, both pre- and post-diagnosis which influence prognosis and quality of life. Work with national centres permits patterns of care to be evaluated, providing the evidence-base for implementation of improvements in clinical management of cancer. It is notable that laboratory methods are also providing new avenues for early detection and studies of prognosis, for example with respect to tumour DNA detected in blood.
In addition to original research on cancer prevention the Agency coordinates international expert evaluations of the published scientific evidence on the effectiveness of primary and secondary cancer prevention interventions. These evaluations are primarily published in the IARC Handbooks of Cancer Prevention, in an approach complementary to that of the IARC Monographs. The number of areas able to be evaluated by the Handbooks series will be largely dependent on the success of additional resource mobilization efforts.
Major contributions to Objective 3 are made by EDP, INF, ENV, the Gambia Hepatitis Intervention Study (GHIS) and IMO, with further contributions from CSU and NME.
This area includes three broad categories of projects which aim:
a. to enhance understanding of interventions for cancer prevention and control;
b. to enhance the implementation of cancer prevention and control programmes;
c. to provide expert evaluations of the available evidence-base in order to recommend prevention strategies.
Scientific Council SC/53/9 Rev.1 Proposed Programme and Budget 2018–2019 (Revision 1) Page 9 The 2016–2017 budget saw a significant increase of nearly €2 million assigned to Objective 3 compared to 2014–2015, resulting in an allocation of 10.18% of the overall budget compared to 5.61%. The proposed 2018–2019 budget maintains a similar overall level of allocation but with some important underlying changes in distribution.
The fieldwork for the long-term GHIS project will be completed by the end of 2018. Therefore, given budgetary constraints and competing demands, a decision has been taken to cut the regular budget support to the GHIS project during the biennium, resulting in a reduction of €169 600 to this project’s budget in 2018–2019 compared to 2016–2017. This reduction enables the maintenance of key positions in other areas of the Agency’s Programme under Objective 3. Nevertheless, given the valuable research platform of the GHIS in The Gambia, co-located with the Medical Research Council UK Gambia Unit, extrabudgetary resources will be sought for new research projects in the hope of maintaining the IARC staff and infrastructure in this unique field setting.
The opportunities for research on prevention and implementation continue to grow. In order to support these initiatives and to add value to extrabudgetary resources, the Agency has used UB to support two scientist positions and a new database manager post in EDP over the 2018–2019 biennium, studying the prevention of gastric, cervical and breast cancers.
In order to permit the relaunch of the Handbooks of Cancer Prevention, additional time has been allocated from existing scientific and support staff in IMO, combined with an allocation of a scientist position financed from the UB. The non-staff budget for the Handbooks has also been increased on the regular budget by €95 800, enabled by changes to the GHIS project mentioned above.
The evaluation of cancer prevention initiatives in one region highlights opportunities and the potential added-value in transferring these experiences to other regions of the world. Two examples are the European Code against Cancer (ECAC) and the Implementation of Cancer Screening in the European Union. The ECAC was developed under the leadership of the Agency. There are opportunities to build on and modify this Code and the underlying methodology for other regions of the world, if additional resources can be identified. A modest resource has been assigned in the 2018–2019 proposed budget to facilitate this initiative. Following the studies of the implementation of cancer screening in Europe the Agency has identified a number of quality indicators which could be applied in other geographic regions to track progress on screening programmes. A proposed Cancer Screening in Five Continents project will be the subject of resource mobilization efforts, permitting periodic evaluation of population based cancer screening programmes in different countries using a basic set of process and outcome measures in a harmonized manner.
Objective 4 - Increase the capacity for cancer research
The development of capacity for cancer research is one of the statutory roles of IARC and thus remains a key element of its mission. However, the contributions under this broad objective cover three main and rather distinct components.
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The first component is focused on people with the aim of developing knowledge and skills in cancer research with emphasis on countries where capacity remains limited. The education and training programme is restricted to core areas of IARC expertise and is integrated with the scientific activities, meaning much of the training is delivered in the context of collaborative research projects. More structured training is provided through the fellowships and courses programmes hosted at IARC (including the IARC Summer School) and training courses associated with specific projects. The Agency has worked with international partners to create and develop the Biobank and Cohort Building Network in low-income countries, providing training in biobanking and the associated legal and ethical considerations. In order to improve access to learning materials the Agency places increasing effort into producing e-Learning materials and translations into different languages beyond the two official IARC languages.
The second component is focused on methods, notably the development of research capacity and tools for epidemiology and laboratory research, such as new or improved methodologies in biostatistics, bioinformatics, exposure assessment and biomarkers. Increased emphasis on statistical methods and modelling, for example of the burden of cancer linked to certain exposures or the impact of different preventive interventions, permit the benefits of investments to be more easily considered at national or international level. The wider range of methodological developments are closely aligned to ongoing research on causes and prevention of cancer and frequently find application to projects assigned to Objectives 2 and 3 of the Project Tree, often preceded by pilot studies.
The third component under this objective is the provision of infrastructure for research. This comprises support in information technology, laboratory services and platforms (genetics, histology) and biobanking facilities.
The overall coordination of the formal training activities of the Agency is provided by the Education and Training Group (ETR) within the Director’s Office. Training courses associated with specific projects are delivered by those Sections involved, with examples from EDP, CSU, NME, LSB and GEN. Several different Sections are involved in methods development including INF, ENV, NME, MCA, and GEN, while the infrastructure for research is provided mainly through the Laboratory Services and Biobank Group (LSB) and the Section of Support to Research (SSR). In addition, strategic research investment is managed through the Director’s Office (DIR).
The main objectives in this area are therefore:
a. to increase human resources for cancer research;
b. to develop new methodologies for cancer research;
c. to provide the resources and infrastructure to support and enhance research.
Overall, the resources assigned to this area have seen an increase to 25.58% of the proposed budget for 2018–2019, from 23.68% in 2016–2017. This increase partly reflects changes in emphasis for some of the existing research Sections. Most notably the NME Section has been restructured following the arrival of a new Section Head, with the Dietary Exposure Assessment Group (DEX) being abolished and the creation of a new Nutritional Methodology and Biostatistics Group (NMB). Through these changes NME has focused additional resources into methodologies which fall under area (b) mentioned above. In addition, GEN has assigned more staff resources
Scientific Council SC/53/9 Rev.1 Proposed Programme and Budget 2018–2019 (Revision 1) Page 11 to maintaining some of the exceptional epidemiological cohort studies available to IARC (e.g. in Russian Federation and Iran) as well as a new initiative to create a European Cohort Consortium.
In relation to area (a), the Agency faces a reduction in activity, nearly halving the number of available IARC Fellowships (from an average of 18 two-year awards per biennium to just 10) because of changes in eligibility for extrabudgetary funding from the European Commission. In order to maintain an effective programme while pursuing alternative funding, the Agency will henceforth restrict the award of IARC Fellowships to candidates from LMICs and has assigned an additional €80 000 in the 2018–2019 budget to the Fellowship Programme to partially mitigate the above changes and allow the award of one additional Fellowship, bringing the total to 11 two-year Postdoctoral Fellowships funded on the regular budget over the biennium.
Objective 5 - Provide strategic leadership and enhance the impact of the Agency’s contribution to global cancer research
This area comprises the activities relating to the definition and implementation of the scientific strategy and programme, supporting the fulfilment of the Agency’s objectives and its leadership in promoting and shaping cancer prevention and control internationally.
The Director is responsible for defining the vision, setting the strategy, and overseeing the implementation of the Agency’s research programme, being supported in these functions by the Senior Leadership Team (SLT), and at an operational level by the Heads and senior staff in each of the Sections and Groups.
This area also includes the support to the governance structures of IARC, the management of strategic partnerships and of communications, as well as the oversight of compliance with ethical and professional standards in the Agency’s activities and research. Success depends on the development and maintenance of key strategic partnerships with WHO, other UN agencies, regional cancer networks, national cancer organizations, non-governmental organizations, etc.
Dissemination of IARC’s research is a foundation to translating the scientific findings into cancer control measures and also falls under this objective.
Activities in this area are coordinated primarily by the Director’s Office (DIR) and its Communications Group (COM) with contributions from the Section of Support to Research (SSR) and all scientific Sections.
The main objectives in this area are therefore:
a. to define the vision and implement the scientific strategy for the Agency, providing the framework for the fulfilment of its objectives;
b. to oversee the strategic direction of the Agency and the implementation of its programme;
c. to create and maintain key strategic partnerships with national, regional and international organizations;
d. effectively communicate and disseminate the work of the Agency.
The Agency is rightly subject to scrutiny of its policies and procedures, particularly when performing evaluation of carcinogenic agents, preventive interventions, or classification of
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tumours, for example. There is need for standard, streamlined approaches to assessing perceived or real conflicts of interest among all the scientists IARC calls upon as experts as well as the potential donors to its work. The new WHO Framework for Engagement with Non-State Actors and the WHO Ethics and Compliance Office provide important points of reference for the Agency in this context. Efficient and transparent ethical evaluation of all IARC projects remains an essential foundation to all research conducted by Agency scientists. In order to be able to coordinate these areas in an efficient and effective manner and to be able to liaise with colleagues at WHO, the Agency has decided to add one junior professional post to the Director’s Office in the role of Ethics and Compliance Officer. This investment explains the overall increase in total posts by 0.4 in the 2018–2019 budget compared to the previous biennium.
IARC can add value to its research outputs by increasing the dissemination of its findings. During the 2014–2015 biennium the Agency allocated resources for the first time to a Press Officer. In the 2018–2019 biennium the need for an additional post, focused on social media and other multimedia communication formats, has been identified as a priority. In order to maintain the current staffing quota on the regular budget and to avoid reducing scientific staff, this general service staff position is to be financed from the Programme Support Cost account rather than the regular budget.
In addition to the above-mentioned areas, which concern predominantly internal functions, the Agency is also able to shape the international cancer research agenda externally. This latter role is achieved in a number of different ways. First, senior IARC scientists are frequently invited to participate in national and international fora, committees, working and advisory groups to advise on cancer research and cancer control agendas. These contributions are not easily attributed a given amount of person-time and are therefore encompassed within the resource allocation to Objectives 1 to 4 inclusive. It is intended, however, to present these contributions as a part of the Medium-Term Strategy Evaluation Framework. Second, there are specific initiatives taken at an Agency level to shape the international agenda. Specific examples include the Cancer Prevention Europe (CPE) initiative, cooperation with WHO to promote cancer control among Member States and the contribution to the United Nations Inter-Agency Task Force (IATF) on NCDs. In the case of CPE, the Agency has assembled a consortium of a number of leading European cancer research centres to define the scope of cancer prevention, identify the major contributors and advocate for the topic at a European level. This initiative may serve as a model for other regions. In relation to WHO Member States, the Agency is working, for example, with colleagues at WHO towards a cancer resolution at the World Health Assembly 2017. IARC is also an active member of two of the three multi-agency joint projects emerging from the IATF, in close collaboration with WHO and other UN partners.
In terms of budget allocation, Objective 5 represents almost the same proportion of the proposed budget 2018–2019 as in the previous biennium (10.65% compared to 10.27%). The increase is related to the additional P2 position of Ethics and Compliance Officer in the Director’s Office.
Scientific Council SC/53/9 Rev.1 Proposed Programme and Budget 2018–2019 (Revision 1) Page 13 Objective 6 - Enable and support the efficient conduct and coordination of research
This objective groups the broad range of activities of IARC’s general management and administrative support structures, which enable the efficient implementation of the scientific programmes, operational effectiveness and optimal management of the Agency’s human, material and financial resources. It comprises activities such as finance, human resources, information technology, and general administrative support, including premises security. Sound financial management ensures that expenditures are properly authorized, processed and recorded, that assets are safeguarded and liabilities correctly quantified, and that financial reporting is accurate and timely.
Activities in this area are undertaken by the Section of Support to Research (SSR) in close collaboration with all the scientific Sections and Groups.
This area includes projects whose primary objectives are:
a. to ensure the Agency is directed and managed according to highest sector standards;
b. invest strategically towards increasing IARC’s capacity.
The regular budget allocated to this area will be further reduced in biennium 2018–2019. This is the result of a sustained effort by SSR to improve the efficiency of services by streamlining processes, renegotiating major external contracts, and increasing the effectiveness of general management and administrative services staff, while further reducing administrative costs by introducing additional cost-efficiency measures. In global terms this resulted in a decrease of the administrative budget as a fraction of the total regular budget to 19.69% in 2018–2019 from 20.17% in 2016–2017.
A novel Business Intelligence tool, aligned with evolving business needs and trends, will provide senior management with transparent, up to date, and accurate information in support of the decision-making process. IARC has reviewed its investments in Enterprise Resource Planning (ERP) solutions over the past 8 years and validated its plan for future IT investments to further automate essential administrative processes.
IARC volunteered to take part in the Project Management Institute (PMI) Project Management Excellence initiative led by WHO and supported by the Bill and Melinda Gates Foundation. Against a set of standard operational efficiency and effectiveness indicators, this initiative resulted in a favourable self-assessment for IARC in 2016, which will be used as a benchmark for further improvements in future biennia.
Consistent with the goals of improved compliance and achievement of general management and administrative excellence, IARC has set out to close all pending audit recommendations from previous years. This is a major achievement, reflecting the full commitment of IARC senior management.
The Nouveau Centre building project is on track with the construction and fitting works scheduled from 2018 to 2021.
SC/53/9 Rev.1 Scientific Council Page 14 Proposed Programme and Budget 2018–2019 (Revision 1)
3. PROPOSED BUDGET 2018–2019
The proposed budget 2018–2019 is the second biennial budget within the MTS 2016–2020. It is developed in euros in accordance with Article III.3.1 of the IARC Financial Regulations. The presentation of the proposed budget follows the structure set out in the IARC Project Tree according to the six main Level 2 objectives with further details at the Level 3 objectives in some tables.
3.1 Explanation of the proposed regular budget
3.1.1 Overall regular budget and distribution
The regular budget proposed for 2018–2019 biennium is €45 073 300. The distribution of the proposed budget reflects the prioritization of resources across the six main objectives of the Project Tree as described in section 2 of this document. The table below compares the distribution of the proposed regular budget with the previous approved biennial budget.
Level 2 Objectives 2016–2017
(in euros) % 2018–2019
(in euros) % 1. Describe the occurrence of cancer 3 170 478 7.30 3 507 393 7.78
2. Understand the causes of cancer 12 325 676 28.39 11 871 734 26.34
3. Evaluate and implement cancer prevention and control strategies
4 420 264 10.18 4 487 103 9.96
4. Increase the capacity for cancer research 10 281 347 23.68 11 531 303 25.58
5. Provide strategic leadership and enhance the impact of the Agency’s contribution to global cancer research
4 458 253 10.27 4 800 745 10.65
6. Enable and support the efficient conduct and coordination of research
8 757 581 20.17 8 875 022 19.69
Total 43 413 599 100.00 45 073 300 100.00
Further information of the proposed budget can be found in Summary Tables A, B, C, D, and E. 3.1.2 Staff and non-staff budget distribution
The non-staff budget for 2018–2019 is kept at the same level as in the 2016–2017 budget and the majority is designated for staff costs as shown in the below table. More details of the distribution at objective level are available in Summary Table C.
Budget category 2016–2017
(in euros) % 2018–2019
(in euros) %
Staff budget 32 845 309 75.66 34 484 790 76.51
Non-staff budget 10 568 290 24.34 10 588 510 23.49
Total 43 413 599 100.00 45 073 300 100.00
Scientific Council SC/53/9 Rev.1 Proposed Programme and Budget 2018–2019 (Revision 1) Page 15 Overall, the total number of posts to be funded from the regular budget increases by 0.40 as compared to 2017. The staff budget reflects statutory staff cost increase, net changes in distribution and level of posts resulting from various reorganizations within the Agency during 2016–2017 and foreseen for 2018–2019, including investments in the bioinformatics area.
Staff category 2016 2017 2018 2019
Professional (P) 72.50 73.10 74.00 74.00
General Service (GS) 85.78 85.70 85.20 85.20
Total number of posts 158.28 158.80 159.20 159.20
% Distribution of P:GS 46:54 46:54 46:54 46:54
Summary Table D provides further details on post distribution.
3.1.3 Cost increase
The proposed budget is 3.82% higher than the 2016–2017 approved budget, 2.71% representing a portion of the statutory staff cost increases and 1.11% due to programmatic changes, as summarized below.
For more details, please refer to Summary Tables F and G.
Cost component
Due to programmatic
changes (in euros)
Due to statutory cost
changes (in euros)
Total changes (in euros)
Staff cost increase 462 330 1 177 151 1 639 481
Non-staff cost increase 20 220 0 20 220
Total cost increase 482 550 1 177 151 1 659 701
Total % increase 1.11% 2.71% 3.82%
While non-staff cost remains stable, the staff cost increases foreseen over the next biennium is €1.64 million, €1.18 million due to statutory cost increase and €0.46 million due to programmatic changes.
• Statutory cost increase: The statutory staff cost increase is largely the result of annual step increases for all staff categories and cost adjustments for General Service staff. No cost adjustment for international staff is anticipated and therefore no provision is included in the budget.
• Programmatic changes: The staff cost increase due to programmatic changes reflects the net effect of internal reorganizations resulting from the abolishment and creation of new posts, and revision in grade of existing posts.
To reduce staff cost pressure, the Agency applies a lower TQ rate at 9% instead of 10% to the standard staff cost. The TQ fund was established for financing short term employee benefits and
SC/53/9 Rev.1 Scientific Council Page 16 Proposed Programme and Budget 2018–2019 (Revision 1)
since 2010, the TQ account has been funded by a budgetary provision set at the rate of 10% of professional staff salary and post adjustment, collected through the payroll.
Implementation of the new compensation package for international staff as recommended by the International Civil Servants Commission (ICSC) within WHO and IARC is planned with effective date from 1 January 2017 and accordingly the new conditions of services of staff in the Professional and higher categories are reflected in this budget. 3.2 Financing of the regular budget
Funds from the GCSF account, totalling €2.00 million, were approved to partially finance IARC’s regular budget since 2012 (i.e. €1.00 million for 2012–2013 budget, €0.50 million for 2014–2015 budget, and €0.50 million for 2016–2017 budget). To phase out this reliance on the GCSF, the 2018–2019 regular budget is proposed to be solely funded from assessed contributions from Participating States as presented in the table below. This includes the contribution from Morocco joining IARC in 2015 and starting to pay its full assessed contributions towards the 2018–2019 Programme Budget, in accordance with Governing Council Resolution GC/57/R1.
Funding Source 2016–2017
(in euros) 2018–2019
(in euros) % Change
Assessed contributions (excl. Morocco) 42 913 599 43 811 248 2.09%
Assessed contributions from Morocco 0 1 262 052 2.94%
Total assessed contributions 42 913 599 45 073 300 5.03%
GCSF 500 000 0
Total regular budget 43 413 599 45 073 300 3.82%
The proposed budget represents an overall increase of €1.66 million or 3.82% from the previous biennium to enable the Agency to cover programmatic changes and increased statutory staff costs. This is largely made possible by Morocco’s full contributions of approximately €1.26 million, together with an increase of just under €0.90 million of the assessed contributions from the remaining 24 Participating States, in large part to cover the proposed absence of GCSF financing. Assessments on Participating States:
The assessments on Participating States are based on the method approved by the Governing Council under Resolution GC/15/R9, which references group classification of countries to the WHO scale of assessment that is in turn based on the United Nations scale of assessment.
In December 2015, the United Nations General Assembly adopted a new scale of assessment for the three-year period 2016–2018 (United Nations General Assembly Resolution 70/245), leading to the revision of the WHO scale of assessments which was approved by the World Health Assembly in May 2016 (Resolution WHA69.14). This WHO revised scale of assessment is the basis for group classification and assessment on IARC Participating States in the proposed 2018–2019 budget.
Scientific Council SC/53/9 Rev.1 Proposed Programme and Budget 2018–2019 (Revision 1) Page 17 Summary Tables H and I provide the details of year-on-year financing and assessments of contribution for each Participating State. The impact of the proposed budget on each individual Participating State as compared to the approved 2016–2017 budget varies between 0.83% and 5.89%, with exceptions on three Participating States, as summarized below.
% Change Amount change*
(in euros) Participating States (excluding Morocco)
0.83% 10 405 Group 5: Ireland, Qatar
2.18% 24 681 Group 4: Austria, Belgium, Denmark, India, Netherlands, Norway, Sweden, Switzerland, Turkey
3.16% 54 866 Group 3: Australia, Brazil, Canada, Russian Federation, Spain
4.47% 99 325 Group 2: France, Germany, United Kingdom
5.89% 188 248 Group 1: Japan, United States of America
-15.56% (232 502) Finland – changed from Group 4 to 5
-19.38% (430 948) Italy – changed from Group 2 to 3
19.92% 297 773 Republic of Korea – changed from Group 4 to 3
*Amount increase/(decrease) is for the biennium budget. The revision of the WHO scale of assessment as mentioned above results in Finland, Italy, and Republic of Korea changing grouping according to IARC’s assessment method. For reference to group classification and comparison with three previous biennium budgets, please refer to Information Table D. To this effect, Finland and Italy will be paying less as they will move from Group 4 to 5 and from Group 2 to 3, respectively. Republic of Korea will move back to Group 3 where it was in the 2012–2013 biennium and prior budget periods, resulting in an increase in its assessment. The reduction of assessments to Finland and Italy have to be absorbed by all other Participating States, including Republic of Korea, accordingly.
Should the WHO scale of assessment have remained unchanged, the impact of the proposed budget increase and an absence of GCSF financing would have been distributed across all Participating States more consistently between 0.83% and 3.39%. Information Table E comparing the assessments on Participating States based on the current and revised scales is provided in the Annex for illustration purpose. 3.3 Extrabudgetary resources
Secured extrabudgetary resources:
IARC programme and budget planning follows the integrated budget approach by considering all funding sources from both regular and extrabudgetary resources for implementing the proposed programme. Extrabudgetary resources include the secured voluntary designated contributions at the time of budget preparation (September 2016) and resources from the PSC account and the GCSF account.
The estimated extrabudgetary resources are expected to increase significantly in the proposed budget 2018–2019, as shown below. More details are available in Summary Tables B and E.
SC/53/9 Rev.1 Scientific Council Page 18 Proposed Programme and Budget 2018–2019 (Revision 1)
Level 2 Objectives 2016–2017
(in euros) % 2018–2019
(in euros) % 1. Describe the occurrence of cancer 1 320 347 16.03 1 548 154 9.45
2. Understand the causes of cancer 1 293 487 15.70 5 878 621 35.86
3. Evaluate and implement cancer prevention and control strategies
1 339 895 16.27 3 823 810 23.33
4. Increase the capacity for cancer research 1 782 432 21.64 1 503 440 9.17
5. Provide strategic leadership and enhance the impact of the Agency’s contribution to global cancer research
327 789 3.98 998 669 6.09
6. Enable and support the efficient conduct and coordination of research
2 172 736 26.38 2 638 350 16.10
Total 8 236 686 100.00 16 391 044 100.00
This increase in availability of extrabudgetary resources reflects the on-going success of the Agency’s scientists in obtaining competitive research funding and growing direct contributions, notably the multi-year grants supporting Objectives 2, 3 and 4, while several investments from PSC and GCSF accounts are distributed across other objectives.
Funds in the PSC account are collected from designated voluntary contributions and are utilized mainly in Objective 6. The Agency is increasing its investment of PSC funds and in biennium 2018–2019 plans to continue to strengthen its capacity in the areas of social media and communication (Objective 5) by adding a new LY5/Social Media post in the Communications Office. The PSC fund would also be used to support the Nouveau Centre project, preparing the move to the new building (Objective 6).
Funds from the GCSF account include 75% of the revenue from publications, which are returned to the Publications programme, supporting inter alia the production of the WHO Classification of Tumours Series (Objectives 1 and 5). They also include the UB allocated to supplement the limited regular budget to build up the bioinformatics area (Objectives 2 and 4).
Resource gaps:
Notwithstanding the increased success thus far in mobilizing voluntary contributions as well as raising funds through PSC and GCSF, several high value projects of the Agency still have large funding shortfalls, hindering their potential and risking their continuity. Amongst those, seven projects listed below are of highest priority for resource mobilization with a total target of €13.72 million for 2018–2019. Additional information in reference to these projects including project summary and expected deliverables are provided in Information Table G.
1. Global Initiative for Cancer Registry Development (GICR) (Objective 1). The GICR aims to contribute to the development of in-country capacity for cancer surveillance through structured support to high-quality population-based cancer registries. Coordinated by IARC, six IARC Regional Hubs serve as a first point of contact to provide technical training, consultancies through site visits, mentorship and analysis to produce scientific and policy reports. To implement these activities, a budget of €5.98 million is required for the biennium,
Scientific Council SC/53/9 Rev.1 Proposed Programme and Budget 2018–2019 (Revision 1) Page 19
of which €1.64 million is being sought to support core infrastructure costs and operations of the six IARC Regional Hubs.
2. IARC Monographs Programme (Objective 2). In view of the worldwide impact of the Monographs and the capacity within the current team to publish the results soon after the assessments of agents and exposures that present carcinogenic hazards to humans, the programme urgently requires additional staff with expertise in quantitative exposure assessment and in scientific editing to help to shorten the time interval from the conclusion of an evaluation to the publication of the final Monograph. Additional funding of €0.42 million is required for the biennium.
3. Multicentric study of cervical cancer screening and triage with human papillomavirus testing (ESTAMPA) (Objective 3). ESTAMPA is an international effort in Latin America to implement organized HPV-based cervical screening and reduce cervical cancer mortality among women in the region. The budget of the study for 2016–2020 amounts to €15 million, including €2 million required for the 2018–2019 biennium. In-kind contributions are expected from local governments and universities participating in the study. The additional voluntary contributions will accelerate the evaluation of new biomarkers and approaches for cervical cancer control and consolidate the wide network of investigators in the region.
4. Cancer Screening in Five Continents (CanScreen5) (Objective 3). This emerging project is expected to result in country improvements in screening programme management and quality assurance, strengthening health information systems, and ultimately in supporting the collection of screening data and promoting their use, informing policy development and research in cancer prevention and early detection. This new project remains mostly unfunded. The five year project budget is estimated at €3.00 million with the estimated amount of €1.2 million required for the 2018–2019 biennium, i.e., first phase.
5. IARC Handbooks of Cancer Prevention (HCP) (Objective 3). Since their re-launch in 2014, Handbooks have been scheduled every 18 months on average, with very limited resources, and support from the staff of the Monographs Programme. The aim is to secure long-term funding dedicated to the Handbooks to build the sustainability of the programme to be able to publish one Handbook per year. The total cost of one Handbook is €0.52 million, hence €1.04 million funding would be required for the 2018–2019 biennium.
6. IARC Fellowship Programme (Objective 4). The programme has contributed to the development of human resources for cancer research worldwide. The Agency remains particularly committed to promoting the development of expertise in cancer research in LMICs by training researchers from these countries. External funding for this programme was secured through two consecutive EC MSCA FP7-COFUND grants, complemented with bilateral agreements with Cancer Council Australia and the Irish Cancer Society, which allowed the expansion of the Fellowships since 2010. Additional funding is being sought to ensure its sustainability as the Agency was informed in 2015 that it is no longer considered eligible for the EU co-funding. To be able to maintain the same number of fellowships awarded per year, a shortfall of €0.56 million needs to be met over the biennium through other funding sources.
SC/53/9 Rev.1 Scientific Council Page 20 Proposed Programme and Budget 2018–2019 (Revision 1)
7. IARC “Nouveau Centre” Plus (Objective 6). The total budget of €49.26 million has been secured for the Nouveau Centre core project to cover building costs and partially cover infrastructure and equipment costs. Additional funding of €7.78 million is required to cover additional costs not included in the core project budget, such as design and installation of offices, meeting rooms and public facilities; renewal of IARC’s scientific equipment; and physical move to the new premises. €5.04 million of this additional funding requirement remains unfunded and will need to be mobilized over the next five years, with the target of €2.52 million for 2018–2019.
Overall budget inclusive of extrabudgetary resources:
Should the resource gaps of the seven priority projects be filled, the budget for implementation of activities in the 2018–2019 biennium, combining with the proposed regular budget and extrabudgetary resources already secured, would be €75.18 million. Figure 4 provides an overview of resource distribution by six priority objectives, inclusive of the project resource gaps. It should be noted that this Figure does not include additional extrabudgetary resources required for other areas of MTS activity that would normally be anticipated to be obtained from competitive funding sources during the biennium.
Figure 4 – Resource distribution inclusive of gaps in seven priority projects
The proposed regular budget for 2018–2019 amounting to €45.07 million is around 60% of all the above resources combined, representing the foundation needed to implement the activities necessary to deliver the MTS.
Scientific Council SC/53/9 Rev.1 Proposed Programme and Budget 2018–2019 (Revision 1) Page 21 4. BUDGET TABLES
The proposed 2018–2019 budget is presented in the following nine summary tables, of which six tables include the 2016–2017 approved budget for comparison purposes.
• Table A - Proposed regular budget for the biennium 2018–2019: Provides the overall proposed budget including the breakdown of budget at the level 2 objectives of the IARC Project Tree for the biennium.
• Table B - Summary of biennial resources by level 2/3 objectives and sources of fund: Includes financial resources overview with breakdown of budget at the level 2 and level 3 objectives of the IARC Project Tree inclusive of the proposed regular budget allocations and projected extrabudgetary resources (i.e. voluntary contributions, PSC account, and GCSF). The 2016–2017 figures are also provided for comparison.
• Table C - Summary of regular budget by level 2/3 objectives and year: Presents further details of the proposed regular budget allocations by year, broken down by staff and non-staff budget.
• Table D - Summary of regular budget funded staff by level 2/3 objectives and staff category: Summarizes the staff in person-years funded by regular budget, allotted to each objective at the level 2 and level 3 objectives of the IARC Project Tree in comparison with the approved figures of 2016–2017. Number of staff is grouped according to the staff categories.
• Table E - Analysis of staffing and resources by level 2/3 objectives: Provides details of the proposed budget and staffing for 2018–2019 at the level 2 and level 3 objectives of the IARC Project Tree.
• Table F - Summary of budget changes from previous biennial budget: Illustrates overall changes to the budget level for 2018–2019 from the approved budget 2016–2017.
• Table G - Summary of regular budget by component and cause of increase/decrease: Presents the proposed budget by component of expenditure in comparison with the approved budget 2016–2017. The increases or decreases are classified based on two main criteria, i.e. programme requirement and cost changes.
• Table H - Summary of regular budget and proposed financing: Provides a summary of the proposed regular budget and proposed funding sources by year, in comparison with those approved for the 2016–2017 budget.
• Table I - Summary of proposed financing from assessments on Participating States and Governing Council Special Fund: Provides the details of assessments on Participating States and other resources required to fund the proposed budget, including comparison with those approved for the 2016–2017 budget.
SC/53/9 Rev.1 Scientific Council Page 22 Proposed Programme and Budget 2018–2019 (Revision 1)
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Scientific Council SC/53/9 Rev.1 Proposed Programme and Budget 2018–2019 (Revision 1) Page 23
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SC/53/9 Rev.1 Scientific Council Page 24 Proposed Programme and Budget 2018–2019 (Revision 1)
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ccor
ding
to h
ighes
t sec
tor s
tand
ards
8,24
8,42
18,
396,
099
2,16
1,07
42,
489,
974
6.2
Inve
st str
ateg
ically
towa
rds i
ncre
asing
IARC
’s ca
pacit
y 50
9,16
047
8,92
390
,200
148,
376
8,75
7,58
120
.17
8,87
5,02
219
.69
2,25
1,27
42,
638,
350
TOTA
L43
,413
,599
100.
0045
,073
,300
100.
008,
236,
686
16,3
91,0
44
Note
s:i.
Extr
a-bu
dget
ary r
esou
rces
inclu
de V
olunt
ary C
ontri
butio
ns se
cure
d at
the
time
of b
udge
t sub
miss
ion, f
undin
g fro
m th
e Pr
ogra
mm
e Su
ppor
t Cos
t Acc
ount
and
the
Gove
rning
Cou
ncil S
pecia
l Fun
d.
Sum
mar
y Ta
ble
BSU
MM
ARY
OF B
IENN
IAL
RESO
URCE
S BY
LEV
EL 2
/3 O
BJEC
TIVE
S AN
D SO
URCE
S OF
FUND
(exp
ress
ed in
eur
os)
Ex
tra-B
udge
tary
Res
ourc
es(s
ee n
ote
i)Re
gular
Bud
get
Scientific Council SC/53/9 Rev.1 Proposed Programme and Budget 2018–2019 (Revision 1) Page 25
Leve
l 2Le
vel 2
Obj
ectiv
es20
1820
1920
18-2
019
Leve
l 3Le
vel 3
Obj
ectiv
esSt
aff
Non-
Staf
fTo
tal
Staf
fNo
n-St
aff
Tota
lSt
aff
Non-
Staf
fTo
tal
Budg
etBu
dget
Budg
etBu
dget
Budg
etBu
dget
1De
scrib
e th
e oc
curr
ence
of c
ance
r1.
1Im
prov
e an
d ex
pand
repo
rting
of d
escr
iptive
canc
er st
atist
ics93
3,57
190
,000
1,02
3,57
195
8,24
490
,000
1,04
8,24
41,
891,
815
180,
000
2,07
1,81
51.
2Su
ppor
t im
prov
ed co
vera
ge a
nd q
uality
of c
ance
r reg
istra
tion,
par
ticula
rly in
low
and
midd
le-inc
ome
coun
tries
(LMI
C)33
3,51
595
,000
428,
515
343,
546
95,0
0043
8,54
667
7,06
119
0,00
086
7,06
11.
3Im
prov
e tu
mou
r clas
sifica
tion
to in
form
canc
er re
gistra
tion,
rese
arch
and
trea
tmen
t22
9,02
053
,000
282,
020
233,
497
53,0
0028
6,49
746
2,51
710
6,00
056
8,51
71,
496,
106
238,
000
1,73
4,10
61,
535,
287
238,
000
1,77
3,28
73,
031,
393
476,
000
3,50
7,39
3
2Un
ders
tand
the
caus
es o
f can
cer
2.1
Iden
tify t
he ri
sk fa
ctors
for h
uman
canc
er th
roug
h th
e co
nduc
t of e
pidem
iolog
ical s
tudie
s3,
079,
733
438,
600
3,51
8,33
33,
215,
062
434,
200
3,64
9,26
26,
294,
795
872,
800
7,16
7,59
52.
2Elu
cidat
e m
echa
nism
s of c
arcin
ogen
esis
thro
ugh
the
cond
uct o
f lab
orat
ory s
tudie
s1,
187,
019
209,
700
1,39
6,71
91,
218,
983
209,
700
1,42
8,68
32,
406,
002
419,
400
2,82
5,40
22.
3Pr
ovide
exp
ert e
valua
tions
of t
he a
vaila
ble e
viden
ce-b
ase
to id
entif
y hum
an ca
rcino
gens
790,
527
140,
000
930,
527
808,
210
140,
000
948,
210
1,59
8,73
728
0,00
01,
878,
737
5,05
7,27
978
8,30
05,
845,
579
5,24
2,25
578
3,90
06,
026,
155
10,2
99,5
341,
572,
200
11,8
71,7
34
3Ev
alua
te a
nd im
plem
ent c
ance
r pre
vent
ion
and
cont
rol s
trat
egie
s3.
1En
hanc
e un
ders
tand
ing o
f int
erve
ntion
s for
canc
er p
reve
ntion
and
cont
rol
1,16
1,41
426
9,50
01,
430,
914
1,05
9,23
318
5,50
01,
244,
733
2,22
0,64
745
5,00
02,
675,
647
3.2
Enha
nce
the
imple
men
tatio
n of
canc
er p
reve
ntion
and
cont
rol p
rogr
amm
es53
3,08
561
,500
594,
585
544,
146
61,5
0060
5,64
61,
077,
231
123,
000
1,20
0,23
13.
3Pr
ovide
exp
ert e
valua
tions
of t
he a
vaila
ble e
viden
ce-b
ase
in or
der t
o re
com
men
d pr
even
tion
strat
egies
235,
269
67,5
0030
2,76
924
0,95
667
,500
308,
456
476,
225
135,
000
611,
225
1,92
9,76
839
8,50
02,
328,
268
1,84
4,33
531
4,50
02,
158,
835
3,77
4,10
371
3,00
04,
487,
103
4In
crea
se th
e ca
pacit
y fo
r can
cer r
esea
rch
4.1
Incr
ease
hum
an re
sour
ces f
or ca
ncer
rese
arch
356,
286
515,
000
871,
286
368,
285
515,
000
883,
285
724,
571
1,03
0,00
01,
754,
571
4.2
Deve
lop n
ew m
etho
dolog
ies fo
r can
cer r
esea
rch
1,59
6,49
520
1,90
01,
798,
395
1,69
2,01
819
6,30
01,
888,
318
3,28
8,51
339
8,20
03,
686,
713
4.3
Prov
ide th
e re
sour
ces a
nd in
frastr
uctu
re to
supp
ort a
nd e
nhan
ce re
sear
ch1,
534,
489
1,47
3,55
03,
008,
039
1,58
2,93
61,
499,
044
3,08
1,98
03,
117,
425
2,97
2,59
46,
090,
019
3,48
7,27
02,
190,
450
5,67
7,72
03,
643,
239
2,21
0,34
45,
853,
583
7,13
0,50
94,
400,
794
11,5
31,3
03
5Pr
ovid
e st
rate
gic
lead
ersh
ip a
nd e
nhan
ce th
e im
pact
of t
he A
genc
y’s
cont
ribut
ion
to g
loba
l can
cer r
esea
rch
5.1
Defin
e th
e vis
ion a
nd im
plem
ent t
he sc
ientif
ic str
ateg
y of t
he A
genc
y, pr
ovidi
ng th
e fra
mew
ork f
or th
e fu
lfilm
ent o
f its
obje
ctive
s40
2,06
327
5,00
067
7,06
340
7,01
727
5,00
068
2,01
780
9,08
055
0,00
01,
359,
080
5.2
Over
see
the
strat
egic
direc
tion
of th
e Ag
ency
and
the
imple
men
tatio
n of
its p
rogr
amm
e87
,994
109,
500
197,
494
91,7
0710
9,50
020
1,20
717
9,70
121
9,00
039
8,70
15.
3Cr
eate
and
main
tain
key s
trate
gic p
artn
ersh
ips w
ith n
ation
al, re
giona
l and
inte
rnat
ional
orga
nizat
ions
231,
759
75,0
0030
6,75
923
5,91
675
,000
310,
916
467,
675
150,
000
617,
675
5.4
Effe
ctive
ly co
mm
unica
te a
nd d
issem
inate
the
work
of t
he A
genc
y93
1,07
127
6,06
01,
207,
131
952,
218
265,
940
1,21
8,15
81,
883,
289
542,
000
2,42
5,28
91,
652,
887
735,
560
2,38
8,44
71,
686,
858
725,
440
2,41
2,29
83,
339,
745
1,46
1,00
04,
800,
745
6En
able
and
sup
port
the
effic
ient
con
duct
and
coo
rdin
atio
n of
rese
arch
6.1
Ensu
re th
e Ag
ency
is d
irecte
d an
d m
anag
ed a
ccor
ding
to h
ighes
t sec
tor s
tand
ards
3,25
2,66
788
6,00
04,
138,
667
3,35
2,91
690
4,51
64,
257,
432
6,60
5,58
31,
790,
516
8,39
6,09
96.
2In
vest
strat
egica
lly to
ward
s inc
reas
ing IA
RC’s
capa
city
149,
971
87,5
0023
7,47
115
3,95
287
,500
241,
452
303,
923
175,
000
478,
923
3,40
2,63
897
3,50
04,
376,
138
3,50
6,86
899
2,01
64,
498,
884
6,90
9,50
61,
965,
516
8,87
5,02
2
TOTA
L17
,025
,948
5,32
4,31
022
,350
,258
17,4
58,8
425,
264,
200
22,7
23,0
4234
,484
,790
10,5
88,5
1045
,073
,300
Sum
mar
y Ta
ble
CSU
MM
ARY
OF R
EGUL
AR B
UDGE
T BY
LEV
EL 2
/3 O
BJEC
TIVE
S AN
D YE
AR(e
xpre
ssed
in e
uros
)
SC/53/9 Rev.1 Scientific Council Page 26 Proposed Programme and Budget 2018–2019 (Revision 1)
Leve
l 2Le
vel 2
Obj
ectiv
es
Leve
l 3Le
vel 3
Obje
ctive
sPr
ofess
ional
Gene
ral
Total
Profe
ssion
alGe
nera
l To
talPr
ofess
ional
Gene
ral
Total
Profe
ssion
alGe
nera
l To
talan
d abo
veSe
rvice
Staff
and a
bove
Servi
ceSt
affan
d abo
veSe
rvice
Staff
and a
bove
Servi
ceSt
aff
1De
scrib
e th
e oc
curr
ence
of c
ance
r1.1
Impr
ove a
nd ex
pand
repo
rting
of de
scrip
tive c
ance
r stat
istics
3.90
4.70
8.60
3.90
4.70
8.60
3.90
4.70
8.60
3.90
4.70
8.60
1.2Su
ppor
t impr
oved
cove
rage
and q
uality
of ca
ncer
regis
tratio
n, pa
rticu
larly
in low
and m
iddle-
incom
e cou
ntries
(LMI
C)1.1
02.3
03.4
01.1
02.3
03.4
01.1
02.3
03.4
01.1
02.3
03.4
01.3
Impr
ove t
umou
r clas
sifica
tion t
o info
rm ca
ncer
regis
tratio
n, re
sear
ch an
d tre
atmen
t0.4
00.4
00.8
01.0
00.4
01.4
01.0
00.6
01.6
01.0
00.6
01.6
05.4
07.4
012
.806.0
07.4
013
.406.0
07.6
013
.606.0
07.6
013
.60
2Un
ders
tand
the
caus
es o
f can
cer
2.1Ide
ntify
the ri
sk fa
ctors
for hu
man c
ance
r thr
ough
the c
ondu
ct of
epide
miolo
gical
studie
s14
.1014
.0228
.1214
.3014
.0228
.3214
.3013
.6527
.9514
.8013
.6528
.452.2
Elucid
ate m
echa
nisms
of ca
rcino
gene
sis th
roug
h the
cond
uct o
f labo
rator
y stud
ies6.5
58.4
014
.956.5
58.4
014
.955.3
06.4
011
.705.3
06.4
011
.702.3
Prov
ide ex
pert
evalu
ation
s of t
he av
ailab
le ev
idenc
e-ba
se to
iden
tify hu
man c
arcin
ogen
s3.8
02.5
06.3
03.8
02.5
06.3
03.8
02.5
06.3
03.8
02.5
06.3
024
.4524
.9249
.3724
.6524
.9249
.5723
.4022
.5545
.9523
.9022
.5546
.45
3Ev
aluat
e an
d im
pleme
nt ca
ncer
pre
vent
ion a
nd co
ntro
l str
ateg
ies3.1
Enha
nce u
nder
stand
ing of
inter
venti
ons f
or ca
ncer
prev
entio
n and
contr
ol6.5
51.9
08.4
56.5
51.9
08.4
56.5
52.6
09.1
55.5
52.6
08.1
53.2
Enha
nce t
he im
pleme
ntatio
n of c
ance
r pre
venti
on an
d con
trol p
rogr
amme
s3.7
01.6
05.3
03.7
01.6
05.3
03.3
50.9
54.3
03.3
50.9
54.3
03.3
Prov
ide ex
pert
evalu
ation
s of t
he av
ailab
le ev
idenc
e-ba
se in
orde
r to r
ecom
mend
prev
entio
n stra
tegies
1.20
0.50
1.70
1.20
0.50
1.70
1.20
0.90
2.10
1.20
0.90
2.10
11.45
4.00
15.45
11.45
4.00
15.45
11.10
4.45
15.55
10.10
4.45
14.55
4In
crea
se th
e ca
pacit
y fo
r can
cer r
esea
rch
4.1Inc
reas
e hum
an re
sour
ces f
or ca
ncer
rese
arch
1.00
3.08
4.08
1.00
3.00
4.00
1.00
3.00
4.00
1.00
3.00
4.00
4.2De
velop
new
metho
dolog
ies fo
r can
cer r
esea
rch6.8
05.4
812
.286.0
05.4
811
.487.5
56.4
013
.958.0
56.4
014
.454.3
Prov
ide th
e res
ource
s and
infra
struc
ture t
o sup
port
and e
nhan
ce re
sear
ch4.3
511
.2015
.554.9
511
.2016
.154.9
012
.1017
.004.9
012
.1017
.0012
.1519
.7631
.9111
.9519
.6831
.6313
.4521
.5034
.9513
.9521
.5035
.45
5Pr
ovide
stra
tegic
lead
ersh
ip an
d en
hanc
e th
e im
pact
of t
he A
genc
y’s c
ontr
ibutio
n to
glob
al ca
ncer
rese
arch
5.1De
fine t
he vi
sion a
nd im
pleme
nt the
scien
tific s
trateg
y of t
he A
genc
y, pr
ovidi
ng th
e fra
mewo
rk for
the f
ulfilm
ent o
f its o
bjecti
ves
1.30
1.50
2.80
1.30
1.50
2.80
1.60
1.25
2.85
1.60
1.25
2.85
5.2Ov
erse
e the
stra
tegic
direc
tion o
f the
Age
ncy a
nd th
e imp
lemen
tation
of its
prog
ramm
e0.0
01.0
01.0
00.0
01.0
01.0
00.0
01.0
01.0
00.0
01.0
01.0
05.3
Crea
te an
d main
tain k
ey st
rateg
ic pa
rtner
ships
with
natio
nal, r
egion
al an
d inte
rnati
onal
orga
nizati
ons
0.65
0.30
0.95
0.65
0.30
0.95
1.35
0.50
1.85
1.35
0.50
1.85
5.4Eff
ectiv
ely co
mmun
icate
and d
issem
inate
the w
ork o
f the
Age
ncy
5.00
3.00
8.00
5.00
3.00
8.00
5.00
3.00
8.00
5.00
3.00
8.00
6.95
5.80
12.75
6.95
5.80
12.75
7.95
5.75
13.70
7.95
5.75
13.70
6En
able
and
supp
ort t
he e
fficie
nt co
nduc
t and
coor
dinat
ion o
f res
earc
h6.1
Ensu
re th
e Age
ncy i
s dire
cted a
nd m
anag
ed ac
cord
ing to
high
est s
ector
stan
dard
s11
.3523
.3034
.6511
.3523
.3034
.6511
.4522
.7534
.2011
.4522
.7534
.206.2
Inves
t stra
tegica
lly to
ward
s inc
reas
ing IA
RC’s
capa
city
0.75
0.60
1.35
0.75
0.60
1.35
0.65
0.60
1.25
0.65
0.60
1.25
12.10
23.90
36.00
12.10
23.90
36.00
12.10
23.35
35.45
12.10
23.35
35.45
TOTA
L72
.5085
.7815
8.28
73.10
85.70
158.8
074
.0085
.2015
9.20
74.00
85.20
159.2
0
(exp
ress
ed in
perso
n yea
rs)SU
MMAR
Y OF
REG
ULAR
BUD
GET F
UNDE
D ST
AFF B
Y LE
VEL 2
/3 O
BJEC
TIVE
S AN
D ST
AFF C
ATEG
ORY
Summ
ary
Table
D
2019
Staf
f Acti
vity
(per
son y
ears)
2018
Staf
f Acti
vity
(per
son y
ears)
2016
Staf
f Acti
vity
(per
son y
ears)
2017
Staf
f Acti
vity
(per
son y
ears)
Scientific Council SC/53/9 Rev.1 Proposed Programme and Budget 2018–2019 (Revision 1) Page 27
Leve
l 2Le
vel 2
Obj
ectiv
esRE
GULA
R BU
DGET
ARY R
ESOU
RCES
EXTR
A-BU
DGET
ARY R
ESOU
RCES
Leve
l 3Le
vel 3
Obje
ctive
sPr
ofess
ional
and a
bove
Gene
ral
Servi
cePr
ofess
ional
and a
bove
Gene
ral
Servi
ce S
taff B
udge
t 20
18-2
019
Non
-staff
Bu
dget
2018
-201
9 T
otal
2018
-201
9 S
taff B
udge
t 20
18-2
019
Non
-staff
Bu
dget
2018
-201
9 T
otal
2018
-201
9
1De
scrib
e th
e oc
curr
ence
of c
ance
r1.1
Impr
ove a
nd ex
pand
repo
rting
of de
scrip
tive c
ance
r stat
istics
3.90
4.70
3.90
4.70
1,891
,815
180,0
00
2,071
,815
133,1
03
-
133,1
03
1.2Su
ppor
t impr
oved
cove
rage
and q
uality
of ca
ncer
regis
tratio
n, pa
rticu
larly
in low
and m
iddle-
incom
e cou
ntries
(LMI
C)1.1
0
2.3
0
1.1
0
2.3
0
67
7,061
19
0,000
86
7,061
11
3,706
12
1,000
23
4,706
1.3
Impr
ove t
umou
r clas
sifica
tion t
o info
rm ca
ncer
regis
tratio
n, re
sear
ch an
d tre
atmen
t1.0
0
0.6
0
1.0
0
0.6
0
46
2,517
10
6,000
56
8,517
69
4,345
48
6,000
1,1
80,34
5
6.0
0
7.6
0
6.0
0
7.6
0
3,0
31,39
3
47
6,000
3,5
07,39
3
94
1,154
60
7,000
1,5
48,15
4
2Un
ders
tand
the
caus
es o
f can
cer
2.1Ide
ntify
the ri
sk fa
ctors
for hu
man c
ance
r thr
ough
the c
ondu
ct of
epide
miolo
gical
studie
s14
.30
13.65
14
.80
13.65
6,2
94,79
5
87
2,800
7,1
67,59
5
56
6,304
3,1
07,08
2
3,6
73,38
6
2.2
Elucid
ate m
echa
nisms
of ca
rcino
gene
sis th
roug
h the
cond
uct o
f labo
rator
y stud
ies5.3
0
6.4
0
5.3
0
6.4
0
2,4
06,00
2
41
9,400
2,8
25,40
2
25
5,186
36
8,450
62
3,636
2.3
Prov
ide ex
pert
evalu
ation
s of t
he av
ailab
le ev
idenc
e-ba
se to
iden
tify hu
man c
arcin
ogen
s3.8
0
2.5
0
3.8
0
2.5
0
1,5
98,73
7
28
0,000
1,8
78,73
7
1,2
32,34
6
34
9,253
1,5
81,59
9
23
.40
22.55
23
.90
22.55
10
,299,5
34
1,572
,200
11,87
1,734
2,0
53,83
6
3,8
24,78
5
5,8
78,62
1
3Ev
aluat
e an
d im
pleme
nt ca
ncer
pre
vent
ion a
nd co
ntro
l str
ateg
ies3.1
Enha
nce u
nder
stand
ing of
inter
venti
ons f
or ca
ncer
prev
entio
n and
contr
ol6.5
5
2.6
0
5.5
5
2.6
0
2,2
20,64
7
45
5,000
2,6
75,64
7
68
7,604
31
2,657
1,0
00,26
1
3.2
Enha
nce t
he im
pleme
ntatio
n of c
ance
r pre
venti
on an
d con
trol p
rogr
amme
s3.3
5
0.9
5
3.3
5
0.9
5
1,0
77,23
1
12
3,000
1,2
00,23
1
50
0,899
2,1
79,00
0
2,6
79,89
9
3.3
Prov
ide ex
pert
evalu
ation
s of t
he av
ailab
le ev
idenc
e-ba
se in
orde
r to r
ecom
mend
prev
entio
n stra
tegies
1.20
0.90
1.20
0.90
476,2
25
135,0
00
611,2
25
81,36
2
62,28
8
143,6
50
11.10
4.4
5
10
.10
4.45
3,774
,103
713,0
00
4,487
,103
1,269
,865
2,553
,945
3,823
,810
4In
crea
se th
e ca
pacit
y fo
r can
cer r
esea
rch
4.1Inc
reas
e hum
an re
sour
ces f
or ca
ncer
rese
arch
1.00
3.00
1.00
3.00
724,5
71
1,030
,000
1,754
,571
-
684,4
01
684,4
01
4.2De
velop
new
metho
dolog
ies fo
r can
cer r
esea
rch7.5
5
6.4
0
8.0
5
6.4
0
3,2
88,51
3
39
8,200
3,6
86,71
3
12
7,345
16
1,356
28
8,701
4.3
Prov
ide th
e res
ource
s and
infra
struc
ture t
o sup
port
and e
nhan
ce re
sear
ch4.9
0
12
.10
4.90
12.10
3,1
17,42
5
2,9
72,59
4
6,0
90,01
9
26
4,223
26
6,115
53
0,338
13
.45
21.50
13
.95
21.50
7,1
30,50
9
4,4
00,79
4
11
,531,3
03
391,5
68
1,111
,872
1,503
,440
5Pr
ovide
stra
tegic
lead
ersh
ip an
d en
hanc
e th
e im
pact
of t
he A
genc
y’s c
ontr
ibutio
n to
glob
al ca
ncer
rese
arch
5.1De
fine t
he vi
sion a
nd im
pleme
nt the
scien
tific s
trateg
y of t
he A
genc
y, pr
ovidi
ng th
e fra
mewo
rk for
the f
ulfilm
ent o
f its o
bjecti
ves
1.60
1.25
1.60
1.25
809,0
80
550,0
00
1,359
,080
-
-
-
5.2Ov
erse
e the
stra
tegic
direc
tion o
f the
Age
ncy a
nd th
e imp
lemen
tation
of its
prog
ramm
e-
1.00
-
1.0
0
17
9,701
21
9,000
39
8,701
-
-
-
5.3
Crea
te an
d main
tain k
ey st
rateg
ic pa
rtner
ships
with
natio
nal, r
egion
al an
d inte
rnati
onal
orga
nizati
ons
1.35
0.50
1.35
0.50
467,6
75
150,0
00
617,6
75
-
-
-
5.4Eff
ectiv
ely co
mmun
icate
and d
issem
inate
the w
ork o
f the
Age
ncy
5.00
3.00
5.00
3.00
1,883
,289
542,0
00
2,425
,289
898,6
69
100,0
00
998,6
69
7.95
5.75
7.95
5.75
3,339
,745
1,461
,000
4,800
,745
898,6
69
100,0
00
998,6
69
6En
able
and
supp
ort t
he e
fficie
nt co
nduc
t and
coor
dinat
ion o
f res
earc
h6.1
Ensu
re th
e Age
ncy i
s dire
cted a
nd m
anag
ed ac
cord
ing to
high
est s
ector
stan
dard
s11
.45
22.75
11
.45
22.75
6,6
05,58
3
1,7
90,51
6
8,3
96,09
9
1,2
72,84
8
1,2
17,12
6
2,4
89,97
4
6.2
Inves
t stra
tegica
lly to
ward
s inc
reas
ing IA
RC’s
capa
city
0.65
0.60
0.65
0.60
303,9
23
175,0
00
478,9
23
93,17
6
55,20
0
148,3
76
12.10
23
.35
12.10
23
.35
6,909
,506
1,965
,516
8,875
,022
1,366
,024
1,272
,326
2,638
,350
TOTA
L74
.00
85.20
74
.00
85.20
34
,484,7
90
10,58
8,510
45
,073,3
00
6,921
,116
9,469
,928
16,39
1,044
Summ
ary
Table
EAN
ALYS
IS O
F STA
FFIN
G AN
D RE
SOUR
CES
BY LE
VEL 2
/3 O
BJEC
TIVE
S
2018
STA
FF A
CTIV
ITY
2019
STA
FF A
CTIV
ITY
(Staf
f acti
vity e
xpre
ssed
in pe
rson y
ears
and b
udge
t exp
ress
ed in
euro
s)
SC/53/9 Rev.1 Scientific Council Page 28 Proposed Programme and Budget 2018–2019 (Revision 1)
Desc
riptio
nAm
ount
(e
uros
)
Perc
enta
gein
crea
se/d
ecre
ase
from
201
6-20
17
1.
Budg
et fo
r 201
6-20
1743
,413
,599
2.
Real
pro
gram
me
incr
ease
/ (d
ecre
ase)
482,
550
1.11
%
3.
Incr
ease
/ (d
ecre
ase)
to u
npro
gram
med
rese
rve
00.
00%
4.
Cost
incr
ease
s / (
decr
ease
s) d
ue to
sta
tuto
ry c
osts
and
infla
tion
1,17
7,15
12.
71%
5.
Budg
et fo
r 201
8-20
1945
,073
,300
3.82
%
Sum
mar
y Ta
ble
FSU
MM
ARY
OF
BUDG
ET C
HANG
ES F
ROM
PRE
VIOU
S BI
ENNI
AL
BUDG
ET
(exp
ress
ed in
eur
os)
Scientific Council SC/53/9 Rev.1 Proposed Programme and Budget 2018–2019 (Revision 1) Page 29
2016
-201
7 Bu
dget
2018
-201
9 Bu
dget
COM
PONE
NT
2016
2017
2016
-201
720
1820
1920
18-2
019
Prog
ram
me
Cost
Tota
l%
Staf
f Bud
get:
Pro
fess
iona
l9,
973,
518
10,4
66,1
5120
,439
,669
10,8
66,7
0011
,035
,068
21,9
01,7
6748
3,66
397
8,43
51,
462,
098
7.15
% G
ener
al S
ervic
e6,
094,
986
6,31
0,65
412
,405
,640
6,15
9,24
96,
423,
775
12,5
83,0
23(2
1,33
3)19
8,71
617
7,38
31.
43%
Tot
al S
taff
Cost
s16
,068
,504
16,7
76,8
0532
,845
,309
17,0
25,9
4817
,458
,842
34,4
84,7
9046
2,33
01,
177,
151
1,63
9,48
14.
99%
Non-
Staf
f Bud
get:
Tem
pora
ry a
ssist
ance
40,0
0040
,000
80,0
0040
,000
59,0
0099
,000
19,0
000
19,0
0023
.75%
Tem
pora
ry a
dviso
rs (e
xper
ts, n
ot c
omin
g fo
r mee
tings
)12
8,83
512
8,83
525
7,67
012
4,30
012
4,30
024
8,60
0(9
,070
)0
(9,0
70)
-3.5
2%Ot
her c
ontra
ctua
l arr
ange
men
ts (A
PWs,
SSA
s an
d co
nsul
tant
s)19
6,80
019
6,80
039
3,60
020
6,70
019
4,70
040
1,40
07,
800
07,
800
1.98
%M
eetin
gs (t
empo
rary
adv
isors
and
par
ticip
ants
) 23
6,50
030
6,50
054
3,00
033
1,50
032
8,50
066
0,00
011
7,00
00
117,
000
21.5
5%Du
ty tr
avel
(all
cate
gorie
s of
sta
ff in
cludi
ng fe
llow
s)45
9,57
045
9,57
191
9,14
146
2,30
045
9,30
092
1,60
02,
459
02,
459
0.27
%Co
llabo
rativ
e re
sear
ch a
gree
men
ts38
7,53
437
4,66
576
2,19
933
3,40
025
8,40
059
1,80
0(1
70,3
99)
0(1
70,3
99)
-22.
36%
Supp
lies
150,
396
150,
636
301,
032
128,
650
128,
890
257,
540
(43,
492)
0(4
3,49
2)-1
4.45
%Eq
uipm
ent a
nd fu
rnitu
re15
6,85
314
5,85
330
2,70
617
2,96
015
2,99
032
5,95
023
,244
023
,244
7.68
%Fe
llow
ship
s73
4,50
073
4,50
01,
469,
000
756,
900
754,
900
1,51
1,80
042
,800
042
,800
2.91
%Of
fice
serv
ices
152,
100
152,
620
304,
720
145,
300
145,
970
291,
270
(13,
450)
0(1
3,45
0)-4
.41%
Publ
icatio
ns (i
nclu
ding
prin
ting)
110,
050
110,
290
220,
340
176,
700
164,
900
341,
600
121,
260
012
1,26
055
.03%
Libra
ry b
ooks
& p
erio
dica
ls16
2,20
017
2,20
433
4,40
414
3,00
015
3,50
029
6,50
0(3
7,90
4)0
(37,
904)
-11.
33%
Labo
rato
ry m
aint
enan
ce a
nd s
uppl
ies
341,
150
341,
150
682,
300
317,
450
317,
450
634,
900
(47,
400)
0(4
7,40
0)-6
.95%
IT m
aint
enan
ce a
nd li
cenc
es
35,0
0035
,000
70,0
0038
,350
39,8
0078
,150
8,15
00
8,15
011
.64%
Build
ing
serv
ices
1,59
5,37
11,
570,
007
3,16
5,37
81,
570,
000
1,61
3,00
03,
183,
000
17,6
220
17,6
220.
56%
Staf
f Dev
elop
men
t & T
rain
ing
95,0
0095
,000
190,
000
99,0
0090
,800
189,
800
(200
)0
(200
)-0
.11%
Dire
ctor
's De
velo
pmen
t Pro
visio
n22
0,00
018
0,00
040
0,00
020
0,00
020
0,00
040
0,00
00
00
0.00
%Ot
hers
86,4
0086
,400
172,
800
77,8
0077
,800
155,
600
(17,
200)
0(1
7,20
0)-9
.95%
5,28
8,25
95,
280,
031
10,5
68,2
905,
324,
310
5,26
4,20
010
,588
,510
20,2
200
20,2
200.
19%
Unpr
ogra
mm
ed re
serv
e0
00
00
00
00
0.00
%
TOTA
L RE
GULA
R BU
DGET
21,3
56,7
6322
,056
,836
43,4
13,5
9922
,350
,258
22,7
23,0
4245
,073
,300
482,
550
1,17
7,15
11,
659,
701
3.82
%1.
11%
2.71
%3.
82%
Note
: Cau
ses
of b
udge
t cha
nges
are
cla
ssifi
ed in
to tw
o gr
oups
i.e.
due
to p
rogr
amm
atic
requ
irem
ents
('Pr
ogra
mm
e') a
nd d
ue to
cos
t cha
nges
('Co
st').
Sum
mar
y Ta
ble
GSU
MM
ARY
OF
REGU
LAR
BUDG
ET B
Y CO
MPO
NENT
AND
CA
USE
OF IN
CREA
SE/D
ECRE
ASE
(exp
ress
ed in
eur
os)
BIEN
NIAL
INCR
EASE
/(DE
CREA
SE)
2016
-201
7 TO
201
8-20
19(s
ee b
elow
not
e)
SC/53/9 Rev.1 Scientific Council Page 30 Proposed Programme and Budget 2018–2019 (Revision 1)
LEVE
L 2
OBJE
CTIV
ES20
1620
1720
16-2
017
%20
1820
1920
18-2
019
%
1.
Des
crib
e th
e oc
curr
ence
of c
ance
r1,
518,
695
1,65
1,78
33,
170,
478
7.30
%1,
734,
106
1,77
3,28
73,
507,
393
7.78
%
2.
Und
erst
and
the
caus
es o
f can
cer
6,04
5,37
86,
280,
298
12,3
25,6
7628
.39%
5,84
5,57
96,
026,
155
11,8
71,7
3426
.34%
3.
Eva
luat
e an
d im
plem
ent c
ance
r pre
vent
ion
and
cont
rol s
trate
gies
2,17
8,44
62,
241,
818
4,42
0,26
410
.18%
2,32
8,26
82,
158,
835
4,48
7,10
39.
95%
4.
Incr
ease
the
capa
city
for c
ance
r res
earc
h5,
093,
809
5,18
7,53
810
,281
,347
23.6
8%5,
677,
720
5,85
3,58
311
,531
,303
25.5
8%
5.
Pro
vide
stra
tegi
c le
ader
ship
and
enh
ance
the
impa
ct o
f the
Age
ncy’s
con
tribu
tion
to g
loba
l can
cer r
esea
rch
2,20
5,07
42,
253,
179
4,45
8,25
310
.27%
2,38
8,44
72,
412,
298
4,80
0,74
510
.65%
6.
Ena
ble
and
supp
ort t
he e
fficie
nt c
ondu
ct a
nd c
oord
inat
ion
of re
sear
ch4,
315,
361
4,44
2,22
08,
757,
581
20.1
7%4,
376,
138
4,49
8,88
48,
875,
022
19.6
9%
Tota
l Reg
ular
Bud
get
21,3
56,7
6322
,056
,836
43,4
13,5
9910
0.00
%22
,350
,258
22,7
23,0
4245
,073
,300
100.
00%
PROP
OSED
FIN
ANC
ING:
(see
Sum
mar
y Ta
ble
I)
Gove
rnin
g Co
uncil
Spe
cial F
und
250,
000
250,
000
500,
000
1.15
%0
00
0.00
%
Parti
cipat
ing
Stat
es A
sses
smen
ts21
,106
,763
21,8
06,8
3642
,913
,599
98.8
5%22
,350
,258
22,7
23,0
4245
,073
,300
100.
00%
Sum
mar
y Ta
ble
HSU
MM
ARY
OF
REGU
LAR
BUDG
ET A
ND P
ROPO
SED
FINA
NCIN
G(e
xpre
ssed
in e
uros
)
Scientific Council SC/53/9 Rev.1 Proposed Programme and Budget 2018–2019 (Revision 1) Page 31
YEAR
201
8YE
AR 2
019
BIEN
NIUM
BI
ENNI
UM20
18-2
019
2018
-201
920
18-2
019
2016
-201
720
16-2
017
2016
-201
7
Num
ber
30%
of t
he 3
0% o
f the
of70
% o
f the
asse
ssed
70%
of t
heas
sess
edPa
rticip
atin
g St
ates
units
asse
ssed
bud
get
TOT
AL
as
sess
ed b
udge
t T
OTAL
TOT
AL
TOTA
L%
Am
ount
assig
ned
bud
get
in a
ccor
danc
e b
udge
t in
acc
orda
nce
incr
ease
/in
crea
se/
(see
Not
e b
orne
with
the
unit
bor
ne w
ith th
e un
it
decr
ease
(dec
reas
e)1
& 2)
equ
ally
s
yste
m e
qual
ly
sys
tem
(s
ee N
ote
3)
Aust
ralia
262
5,80
726
2,94
388
8,75
063
6,24
526
7,32
990
3,57
41,
792,
324
1,73
7,46
13.
1654
,863
Aust
ria1
625,
807
131,
473
757,
280
636,
245
133,
666
769,
911
1,52
7,19
11,
494,
554
2.18
32,6
37Be
lgiu
m1
625,
807
131,
473
757,
280
636,
245
133,
666
769,
911
1,52
7,19
11,
494,
554
2.18
32,6
37Br
azil
262
5,80
726
2,94
388
8,75
063
6,24
526
7,32
990
3,57
41,
792,
324
1,73
7,46
154
,863
Cana
da2
625,
807
262,
943
888,
750
636,
245
267,
329
903,
574
1,79
2,32
41,
737,
461
3.16
54,8
63De
nmar
k1
625,
807
131,
473
757,
280
636,
245
133,
666
769,
911
1,52
7,19
11,
494,
554
2.18
32,6
37Fi
nlan
d0
625,
807
062
5,80
763
6,24
50
636,
245
1,26
2,05
21,
494,
554
-15.
56
(232
,502
)Fr
ance
462
5,80
752
5,88
91,
151,
696
636,
245
534,
660
1,17
0,90
52,
322,
601
2,22
3,27
54.
4799
,326
Germ
any
462
5,80
752
5,88
91,
151,
696
636,
245
534,
660
1,17
0,90
52,
322,
601
2,22
3,27
54.
4799
,326
Indi
a1
625,
807
131,
473
757,
280
636,
245
133,
666
769,
911
1,52
7,19
11,
494,
554
2.18
32,6
37Ire
land
062
5,80
70
625,
807
636,
245
063
6,24
51,
262,
052
1,25
1,64
70.
8310
,405
Italy
262
5,80
726
2,94
388
8,75
063
6,24
526
7,32
990
3,57
41,
792,
324
2,22
3,27
5-1
9.38
(4
30,9
51)
Japa
n8
625,
807
1,05
1,77
91,
677,
586
636,
245
1,06
9,32
01,
705,
565
3,38
3,15
13,
194,
903
5.89
188,
248
Mor
occo
062
5,80
70
625,
807
636,
245
063
6,24
51,
262,
052
00.
001,
262,
052
Neth
erla
nds
162
5,80
713
1,47
375
7,28
063
6,24
513
3,66
676
9,91
11,
527,
191
1,49
4,55
42.
1832
,637
Norw
ay1
625,
807
131,
473
757,
280
636,
245
133,
666
769,
911
1,52
7,19
11,
494,
554
2.18
32,6
37Qa
tar
062
5,80
70
625,
807
636,
245
063
6,24
51,
262,
052
1,25
1,64
710
,405
Repu
blic
of K
orea
262
5,80
726
2,94
388
8,75
063
6,24
526
7,32
990
3,57
41,
792,
324
1,49
4,55
419
.92
297,
770
Russ
ian
Fede
ratio
n2
625,
807
262,
943
888,
750
636,
245
267,
329
903,
574
1,79
2,32
41,
737,
461
3.16
54,8
63Sp
ain
262
5,80
726
2,94
388
8,75
063
6,24
526
7,32
990
3,57
41,
792,
324
1,73
7,46
13.
1654
,863
Swed
en1
625,
807
131,
473
757,
280
636,
245
133,
666
769,
911
1,52
7,19
11,
494,
554
2.18
32,6
37Sw
itzer
land
162
5,80
713
1,47
375
7,28
063
6,24
513
3,66
676
9,91
11,
527,
191
1,49
4,55
42.
1832
,637
Turk
ey1
625,
807
131,
473
757,
280
636,
245
133,
666
769,
911
1,52
7,19
11,
494,
554
2.18
32,6
37Un
ited
King
dom
462
5,80
752
5,88
91,
151,
696
636,
245
534,
660
1,17
0,90
52,
322,
601
2,22
3,27
54.
4799
,326
Unite
d St
ates
of A
mer
ica8
625,
807
1,05
1,77
91,
677,
586
636,
245
1,06
9,32
01,
705,
565
3,38
3,15
13,
194,
903
5.89
188,
248
TOTA
L PA
RTIC
IPAT
ING
STAT
ES
5115
,645
,175
6,70
5,08
322
,350
,258
15,9
06,1
256,
816,
917
22,7
23,0
4245
,073
,300
42,9
13,5
995.
032,
159,
701
TOTA
L GC
SF0
00
500,
000
-100
.00
(500
,000
)
TOTA
L FU
NDIN
G15
,645
,175
6,70
5,08
322
,350
,258
15,9
06,1
256,
816,
917
22,7
23,0
4245
,073
,300
43,4
13,5
993.
821,
659,
701
Note
s:1.
The
met
hod
of a
sses
smen
t of c
ontri
butio
ns o
f Par
ticip
atin
g St
ates
is d
etai
led
in R
esol
utio
ns G
C/15
/R9,
GC/
37/R
9, a
nd G
C/56
/R6.
2. G
roup
cla
ssifi
catio
n of
cou
ntrie
s fo
r the
pur
pose
of a
ssig
ning
uni
ts in
acc
orda
nce
with
the
appl
icabl
e GC
reso
lutio
ns is
bas
ed o
n th
e re
vised
sca
le o
f ass
essm
ents
for W
HO s
tarti
ng 2
017
as a
dopt
ed b
y
the
Wor
ld H
ealth
Ass
embl
y in
May
201
6 (W
HA69
.14)
.3.
Mor
occo
's co
ntrib
utio
n is
inclu
ded
in th
e 5.
03%
incr
ease
s in
the
over
all a
sses
smen
t on
Parti
cipat
ing
Stat
es fo
r 201
8-20
19. W
hen
exclu
ding
Mor
occo
, ove
rall
asse
ssm
ent i
ncre
ase
is 2.
09%
, par
tly to
Sum
mar
y Ta
ble
ISU
MM
ARY
OF
PROP
OSED
FIN
ANC
ING
FROM
ASS
ESSM
ENTS
ON
PART
ICIP
ATI
NG S
TATE
S A
ND G
OVER
NING
COU
NCIL
SPE
CIA
L FU
ND(e
xpre
ssed
in e
uros
)
a
bsor
b an
abs
ence
of t
he G
over
ning
Cou
ncil
Spec
ial F
und
(GCS
F).
SC/53/9 Rev.1 Scientific Council Page 32 Proposed Programme and Budget 2018–2019 (Revision 1)
[Page intentionally left blank]
Scientific Council SC/53/9 Rev.1 Proposed Programme and Budget 2018–2019 (Revision 1) Page 33 ANNEXES
Seven additional tables are also provided hereafter as supplementary information:
• Information Table A - Total staff and non-staff budget by Section and Group: Provides details of staff and non-staff budget annual allocation by Section and Group.
• Information Table B - United Nations accounting rates of exchange: euros to US dollars: Contains the monthly exchange rates set by the United Nations for euros to US dollars from January 2006 to December 2016.
• Information Table C - IARC Project Tree structure and associated projects: Shows the structure of the IARC Project Tree from the highest level objective (level 1) to the most detailed level objectives (level 4) and associated projects contributing to the respective Project Tree path.
• Information Table D - Group classification of countries and assigning units for assessed contributions: Provides supplementary information to the Summary Table I for comparison of the group classification and unit assignment of IARC Participating States in the proposed budget 2018–2019 with three prior approved biennial budgets.
• Information Table E - Comparison of assessments on Participating States based on current and revised scales: Illustrates the assessments on Participating States should the same scale of assessment used for the approved budget 2016–2017 be applied to the proposed budget 2018–2019 in comparison to the assessments based on the revised scale.
• Information Table F - Comparison of proposed regular budget 2018–2019 with approved regular budget 2016–2017 by level 2/3 objectives: Provides supplementary information to the Summary Table B for comparison of the proposed budget 2018–2019 with the approved budget 2016–2017 in equivalent categories of objectives.
• Information Table G - Priority projects requiring additional voluntary contributions: Provides supplementary information to section 3.3 Extrabudgetary resources.
SC/53/9 Rev.1 Scientific Council Page 34 Proposed Programme and Budget 2018–2019 (Revision 1)
[Page intentionally left blank]
Scientific Council SC/53/9 Rev.1 Proposed Programme and Budget 2018–2019 (Revision 1) Page 35
Sec
tion
Gro
up
Sta
ff Bu
dget
Non
-sta
ff Bu
dget
Grou
p To
tal B
udge
tSe
ctio
n To
tal B
udge
t S
taff
Budg
et N
on-s
taff
Budg
etGr
oup
Tota
l Bud
get
Sect
ion
Tota
l Bud
get
Sta
ff Bu
dget
Non
-sta
ff Bu
dget
Grou
p To
tal B
udge
tSe
ctio
n To
tal B
udge
t
Scie
ntifi
c Pr
ogra
mm
e (O
bjec
tive
1-5)
CSU
CSU
1,26
7,08
618
5,00
01,
452,
086
1,45
2,08
61,
301,
790
185,
000
1,48
6,79
01,
486,
790
2,56
8,87
637
0,00
02,
938,
876
2,93
8,87
6
DIR
DI
R 65
0,18
854
5,00
01,
195,
188
1,19
5,18
865
9,44
554
5,00
01,
204,
445
1,20
4,44
51,
309,
633
1,09
0,00
02,
399,
633
2,39
9,63
3
DIR
Oth
ers
COM
99
8,38
327
6,06
01,
274,
443
3,23
0,96
41,
022,
466
265,
940
1,28
8,40
63,
073,
828
2,02
0,84
954
2,00
02,
562,
849
6,30
4,79
2ET
R 35
6,28
651
5,00
087
1,28
636
8,28
551
5,00
088
3,28
572
4,57
11,
030,
000
1,75
4,57
1GH
IS
124,
484
120,
000
244,
484
40,0
0040
,000
124,
484
160,
000
284,
484
LSB
613,
751
227,
000
840,
751
635,
137
227,
000
862,
137
1,24
8,88
845
4,00
01,
702,
888
EDP
PR
I 69
2,71
190
,000
782,
711
1,32
2,55
970
6,02
790
,000
796,
027
1,34
5,93
41,
398,
738
180,
000
1,57
8,73
82,
668,
493
SCR
449,
848
90,0
0053
9,84
845
9,90
790
,000
549,
907
909,
755
180,
000
1,08
9,75
5
ENV
EN
V 1,
088,
794
180,
000
1,26
8,79
41,
268,
794
1,11
5,38
518
0,00
01,
295,
385
1,29
5,38
52,
204,
179
360,
000
2,56
4,17
92,
564,
179
GEN
GC
S 90
7,28
712
8,00
01,
035,
287
1,82
0,95
593
1,23
012
8,00
01,
059,
230
1,86
1,88
91,
838,
517
256,
000
2,09
4,51
73,
682,
844
GEP
678,
668
107,
000
785,
668
695,
659
107,
000
802,
659
1,37
4,32
721
4,00
01,
588,
327
IMO
IMO
1,18
7,50
426
0,50
01,
448,
004
1,44
8,00
41,
212,
415
260,
500
1,47
2,91
51,
472,
915
2,39
9,91
952
1,00
02,
920,
919
2,92
0,91
9
INF
ICB
604,
152
95,0
0069
9,15
21,
664,
755
619,
864
95,0
0071
4,86
41,
700,
507
1,22
4,01
619
0,00
01,
414,
016
3,36
5,26
2IC
E 87
0,60
395
,000
965,
603
890,
643
95,0
0098
5,64
31,
761,
246
190,
000
1,95
1,24
6
MCA
EG
E 57
6,42
295
,000
671,
422
1,35
3,04
759
3,45
695
,000
688,
456
1,38
5,16
01,
169,
878
190,
000
1,35
9,87
82,
738,
207
MM
B58
6,62
595
,000
681,
625
601,
704
95,0
0069
6,70
41,
188,
329
190,
000
1,37
8,32
9
NM
E BM
A69
6,28
761
,000
757,
287
1,82
1,52
282
8,19
261
,000
889,
192
1,96
1,79
91,
524,
479
122,
000
1,64
6,47
93,
783,
321
NEP
555,
749
75,0
0063
0,74
956
6,56
461
,000
627,
564
1,12
2,31
313
6,00
01,
258,
313
NMB
372,
486
61,0
0043
3,48
638
4,04
361
,000
445,
043
756,
529
122,
000
878,
529
SSR
ASO/
ITS
258,
002
940,
750
1,19
8,75
21,
198,
752
268,
055
966,
244
1,23
4,29
91,
234,
299
526,
057
1,90
6,99
42,
433,
051
2,43
3,05
1
SSR
DAF
(GCG
/SCI
)87
,994
109,
500
197,
494
197,
494
91,7
0710
9,50
020
1,20
720
1,20
717
9,70
121
9,00
039
8,70
139
8,70
1
Adm
inis
trat
ive
Prog
ram
me
(Obj
ectiv
e 6)
SSR
ASO
984,
432
779,
500
1,76
3,93
24,
376,
138
1,02
2,57
879
8,01
61,
820,
594
4,49
8,88
42,
007,
011
1,57
7,51
63,
584,
527
8,87
5,02
2BF
O1,
136,
181
29,0
001,
165,
181
1,16
7,87
329
,000
1,19
6,87
32,
304,
054
58,0
002,
362,
054
DAF
402,
493
10,5
0041
2,99
341
1,25
810
,500
421,
758
813,
751
21,0
0083
4,75
1HR
O47
3,62
391
,500
565,
123
490,
082
91,5
0058
1,58
296
3,70
518
3,00
01,
146,
705
ITS
405,
909
63,0
0046
8,90
941
5,07
663
,000
478,
076
820,
985
126,
000
946,
985
TOTA
L 17
,025
,948
5,32
4,31
022
,350
,258
22,3
50,2
5817
,458
,842
5,26
4,20
022
,723
,042
22,7
23,0
4234
,484
,790
10,5
88,5
1045
,073
,300
45,0
73,3
00
Info
rmat
ion
Tabl
e A
TOTA
L ST
AFF
AND
NON
-STA
FF B
UDGE
T BY
SEC
TION
AND
GRO
UP(e
xpre
ssed
in e
uros
)
2018
2019
2018
-201
9
SC/53/9 Rev.1 Scientific Council Page 36 Proposed Programme and Budget 2018–2019 (Revision 1)
2006
2007
2008
2009
2010
2011
2012
2013
2014
2015
2016
Janu
ary
0.84
50.
760
0.68
60.
730
0.69
30.
761
0.77
40.
754
0.72
50.
850
0.92
2
Febr
uary
0.82
70.
771
0.67
60.
762
0.71
40.
734
0.76
30.
737
0.73
70.
882
0.88
2
Mar
ch0.
844
0.75
50.
661
0.78
20.
741
0.72
80.
746
0.77
30.
731
0.94
30.
895
April
0.82
70.
750
0.63
40.
759
0.74
30.
710
0.75
30.
783
0.72
70.
923
0.88
7
May
0.79
10.
732
0.64
20.
744
0.77
40.
675
0.75
50.
764
0.72
30.
904
0.88
2
June
0.77
80.
744
0.64
30.
717
0.81
90.
702
0.80
50.
767
0.73
50.
894
0.89
7
July
0.79
60.
740
0.63
60.
711
0.81
10.
699
0.80
40.
767
0.73
60.
905
0.90
1
Augu
st0.
784
0.73
10.
658
0.71
20.
763
0.70
00.
816
0.75
40.
748
0.91
50.
895
Sept
embe
r0.
780
0.73
40.
698
0.69
50.
787
0.68
80.
797
0.75
50.
759
0.88
90.
897
Octo
ber
0.78
80.
705
0.72
90.
688
0.73
50.
733
0.77
70.
737
0.78
70.
891
0.90
6
Nove
mbe
r0.
786
0.69
40.
773
0.67
60.
720
0.70
70.
772
0.72
60.
803
0.91
20.
920
Dece
mbe
r0.
759
0.67
80.
758
0.66
40.
764
0.75
00.
770
0.73
60.
820
0.91
40.
942
Annu
al A
vera
ge0.
800
0.73
30.
683
0.72
00.
755
0.71
60.
778
0.75
40.
753
0.90
20.
902
Bien
nial
Ave
rage
0.76
70.
701
0.73
50.
766
0.82
720
06/2
007
2008
/200
920
10/2
011
2012
/201
320
14/2
015
Budg
et 2
006/
2007
app
rove
d at
0.8
15 €
/US$
Budg
et 2
010/
2011
app
rove
d at
0.6
60 €
/US$
Budg
et 2
014/
2015
app
rove
d at
0.7
58 €
/US$
Budg
et 2
008/
2009
app
rove
d at
0.8
15 €
/US$
Budg
et 2
012/
2013
app
rove
d at
0.6
75 €
/US$
Budg
et 2
016/
2017
app
rove
d at
0.7
29 €
/US$
Info
rmat
ion
Tabl
e B
UNIT
ED N
ATI
ONS
ACC
OUNT
ING
RATE
S OF
EXC
HANG
E: E
UROS
TO
US D
OLLA
RSFr
om Ja
nuar
y 20
06 to
Dec
embe
r 201
6
Scientific Council SC/53/9 Rev.1 Proposed Programme and Budget 2018–2019 (Revision 1) Page 37
Le
vel 2
/3 O
bjec
tives
Le
vel 4
Obj
ectiv
esPr
ojec
t Num
ber
Proj
ect T
itle
1De
scrib
e th
e oc
curr
ence
of c
ance
r1.
1Im
prov
e an
d ex
pand
repo
rting
of d
escr
iptiv
e ca
ncer
sta
tistic
s1.
1.1
Expa
nd th
e de
scrip
tive
anal
yses
of c
ance
r inc
iden
ce, m
orta
lity,
pr
eval
ence
and
sur
vival
regi
onal
ly an
d w
orld
wid
ePB
.181
9.CS
U.03
Desc
riptiv
e ep
idem
iolo
gy o
f can
cer
1.1.
2Im
prov
e th
e va
lidity
, ran
ge, t
imel
ines
s an
d di
ssem
inat
ion
of
appr
opria
te c
ance
r ind
icato
rs a
vaila
ble
at th
e na
tiona
l, re
gion
al
and
glob
al le
vel
PB.1
819.
CSU.
01Gl
obal
can
cer i
ndica
tors
: dev
elop
men
t and
diss
emin
atio
n
1.2
Supp
ort i
mpr
oved
cov
erag
e an
d qu
ality
of c
ance
r reg
istra
tion,
pa
rticu
larly
in lo
w a
nd m
iddl
e-in
com
e co
untri
es (L
MIC
)1.
2.1
Impr
ove
the
avai
labi
lity,
qua
lity
and
diss
emin
atio
n of
regi
stry
dat
a,
via IA
RC R
egio
nal H
ubs
and
prom
ote
the
role
of p
opul
atio
n-ba
sed
canc
er re
gist
ries
in c
ance
r con
trol p
lann
ing
PB.1
819.
CSU.
02Ca
ncer
regi
stry
sup
port
and
deve
lopm
ent
1.3
Impr
ove
tum
our c
lass
ifica
tion
to in
form
can
cer r
egist
ratio
n,
rese
arch
and
trea
tmen
t1.
3.1
Publ
ish W
HO C
lass
ifica
tion
of T
umou
rs S
erie
sPB
.181
9.IM
O.03
WHO
cla
ssifi
catio
n of
tum
ours
ser
ies
2Un
ders
tand
the
cau
ses
of c
ance
r2.
12.
1.1
Adva
nce
unde
rsta
ndin
g of
the
role
of i
nfec
tious
age
nts
PB.1
819.
ICB.
02De
term
ine
the
role
of i
nfec
tious
age
nts
in d
iffer
ent h
uman
can
cers
PB.1
819.
ICE.
02Sp
ectru
m, n
atur
al h
istor
y, a
nd p
reve
ntio
n of
infe
ctio
n-as
socia
ted
canc
ers
2.1.
2PB
.181
9.EN
V.01
To s
tudy
car
cinog
enic
effe
cts
of e
xpos
ure
to p
rotra
cted
low
dos
es o
f ion
ising
radi
atio
nPB
.181
9.EN
V.02
To s
tudy
exp
osur
e to
non
-ioni
sing
radi
atio
n (e
lect
rom
agne
tic fi
elds
)PB
.181
9.EN
V.03
To s
tudy
can
cers
with
sus
pect
ed e
nviro
nmen
tal,
occu
patio
nal o
r life
style
-rel
ated
cau
ses
PB.1
819.
ENV.
04To
stu
dy u
niqu
e en
viron
men
tal,
lifes
tyle
and
occ
upat
iona
l exp
osur
es
2.1.
3PB
.181
9.BM
A.01
Diet
ary
and
met
abol
ic bi
omar
kers
ass
ocia
ted
with
can
cer a
nd in
term
edia
te e
nd-p
oint
sPB
.181
9.NE
P.01
Mol
ecul
ar e
pide
mio
logi
c st
udie
s of
nut
ritio
n an
d m
etab
olism
and
can
cer
PB.1
819.
NMB.
02Di
etar
y an
d lif
esty
le e
xpos
ures
ass
ocia
ted
with
can
cer a
nd o
ther
non
-com
mun
icabl
e di
seas
es2.
1.4
PB.1
819.
GCS.
01Id
entif
y ge
nes
invo
lved
in c
ance
r dev
elop
men
tPB
.181
9.GE
P.01
Gene
tic e
pide
mio
logy
of t
obac
co a
nd a
lcoho
l rel
ated
can
cer
PB.1
819.
GEP.
02Ki
dney
can
cer m
olec
ular
epi
dem
iolo
gy2.
22.
2.1
Adva
nce
unde
rsta
ndin
g of
bio
logi
cal a
nd c
ellu
lar p
athw
ays
dli
i
iPB
.181
9.EG
E.01
Epig
enet
ic al
tera
tions
in s
tudi
es o
f can
cer c
ausa
tion
and
prev
entio
n
PB.1
819.
ICB.
01Bi
olog
ical p
rope
rties
of i
nfec
tious
age
nts
in in
vitr
o an
d in
vivo
exp
erim
enta
l mod
els
PB.1
819.
MM
B.01
Som
atic
alte
ratio
ns a
nd m
echa
nism
s of
car
cinog
enes
is as
socia
ted
with
exp
osur
e to
env
ironm
enta
l risk
fa
ctor
s2.
2.2
PB.1
819.
EGE.
02Ep
igen
etics
-bas
ed b
iom
arke
rs in
exp
osom
icsPB
.181
9.M
MB.
02M
olec
ular
alte
ratio
ns a
s bi
omar
kers
of e
xpos
ure,
can
cer r
isk a
nd d
etec
tion
2.3
Prov
ide
expe
rt ev
alua
tions
of t
he a
vaila
ble
evid
ence
-bas
e to
id
entif
y hu
man
car
cinog
ens
2.3.
1Pu
blish
IARC
Mon
ogra
phs
and
asso
ciate
d ou
tput
s on
stra
tegi
cally
re
late
d to
pics
PB.1
819.
IMO.
01IA
RC M
onog
raph
s on
the
Eval
uatio
n of
Car
cinog
enic
Risk
s to
Hum
ans
3 3.1
3.1.
1An
alys
e th
e ef
ficac
y of
prim
ary
canc
er p
reve
ntio
n st
rate
gies
PB.1
819.
GHI.0
1Ga
mbi
a He
patit
is In
terv
entio
n St
udy
(GHI
S)PB
.181
9.IC
E.01
Impl
emen
tatio
n an
d m
onito
ring
of H
PV v
accin
atio
n an
d HP
V-ba
sed
scre
enin
g in
low
and
mid
dle-
inco
me
coun
tries
PB.1
819.
PRI.0
3Ep
idem
iolo
gy a
nd p
reve
ntio
n of
gas
tric
canc
er3.
1.2
Anal
yse
the
effic
acy
of s
econ
dary
can
cer p
reve
ntio
n st
rate
gies
PB.1
819.
PRI.0
2Ce
rvica
l can
cer s
cree
ning
stra
tegi
es fo
r low
and
mid
dle
inco
me
coun
tries
3.1.
3En
hanc
e un
ders
tand
ing
of th
e fa
ctor
s af
fect
ing
canc
er p
rogn
osis
PB.1
819.
ENV.
05To
stu
dy li
fest
yle a
nd e
nviro
nmen
tal d
eter
min
ants
of c
ance
r risk
s, p
rogn
osis
and
canc
er o
utco
mes
PB.1
819.
SCR.
03Im
prov
ing
the
qual
ity o
f bre
ast c
ance
r scr
eeni
ng, e
arly
diag
nosis
and
trea
tmen
t ser
vices
in L
MIC
s3.
23.
2.1
PB.1
819.
ENV.
06Ex
pans
ion
and
eval
uatio
n of
Can
cer P
reve
ntio
n Re
com
men
datio
nsPB
.181
9.PR
I.01
Impl
emen
tatio
n st
udie
s of
HPV
vac
cinat
ion
PB.1
819.
SCR.
01Ev
alua
tion
of c
ervic
al c
ance
r con
trol m
easu
res
in d
evel
opin
g co
untri
esPB
.181
9.SC
R.02
Eval
uatio
n of
col
orec
tal a
nd o
ral c
ance
r scr
eeni
ngPB
.181
9.SC
R.04
Canc
er S
cree
ning
Initi
ative
s &
Thei
r Im
pact
in 5
Con
tinen
ts3.
3Pr
ovid
e ex
pert
eval
uatio
ns o
f the
ava
ilabl
e ev
iden
ce-b
ase
in o
rder
to
reco
mm
end
prev
entio
n st
rate
gies
3.3.
1Pu
blish
IARC
Han
dboo
ks o
n Ca
ncer
Pre
vent
ion
PB.1
819.
IMO.
02IA
RC H
andb
ooks
of C
ance
r Pre
vent
ion
Eluc
idat
e m
echa
nism
s of
car
cinog
enes
is th
roug
h th
e co
nduc
t of
labo
rato
ry s
tudi
es
Iden
tify
the
risk
fact
ors
for h
uman
can
cer t
hrou
gh th
e co
nduc
t of
epid
emio
logi
cal s
tudi
es
Adva
nce
unde
rsta
ndin
g of
the
role
of g
enet
ic fa
ctor
s in
influ
encin
g ris
k, a
nd th
eir i
nter
actio
n w
ith n
on-g
enet
ic fa
ctor
s
Adva
nce
unde
rsta
ndin
g of
the
role
of d
ieta
ry, m
etab
olic
and
lifes
tyle
fact
ors
Info
rmat
ion
Tabl
e C
IARC
PRO
JECT
TRE
E ST
RUCT
URE
AND
ASS
OCIA
TED
PROJ
ECTS
LE
VEL
1 OB
JECT
IVE:
Red
uce
the
burd
en o
f can
cer
wor
ldw
ide
thro
ugh
the
cond
uct
of r
esea
rch
Adva
nce
unde
rsta
ndin
g of
the
role
of e
nviro
nmen
tal,
occu
patio
nal
and
iatro
geni
c fa
ctor
s
Appl
y bi
omar
kers
to s
tudi
es o
f can
cer c
ause
s an
d m
olec
ular
ge
netic
cla
ssifi
catio
n of
tum
ours
Iden
tify
fact
ors
influ
encin
g th
e ef
fect
ive im
plem
enta
tion
of p
rimar
y an
d se
cond
ary
prev
entio
n pr
ogra
mm
esEn
hanc
e th
e im
plem
enta
tion
of c
ance
r pre
vent
ion
and
cont
rol
prog
ram
mes
Enha
nce
unde
rsta
ndin
g of
inte
rven
tions
for c
ance
r pre
vent
ion
and
cont
rol
Eval
uate
and
impl
emen
t ca
ncer
pre
vent
ion
and
cont
rol s
trat
egie
s
SC/53/9 Rev.1 Scientific Council Page 38 Proposed Programme and Budget 2018–2019 (Revision 1)
Le
vel 2
/3 O
bjec
tives
Le
vel 4
Obj
ectiv
esPr
ojec
t Num
ber
Proj
ect T
itle
4 4.1
Incr
ease
hum
an re
sour
ces
for c
ance
r res
earc
h4.
1.1
Awar
d fe
llow
ship
s an
d pr
ovid
e tra
inin
g th
roug
h pa
rticip
atio
n in
co
llabo
rativ
e re
sear
ch p
roje
cts
PB.1
819.
ETR.
01IA
RC R
esea
rch
Trai
ning
and
Fel
low
ship
Pro
gram
me
4.1.
2De
liver
trai
ning
cou
rses
, bas
ic an
d ad
vanc
ed, i
n th
e ar
eas
of c
ore
com
pete
ncie
s of
the
Agen
cyPB
.181
9.ET
R.02
IARC
Cou
rses
4.2
Deve
lop
new
met
hodo
logi
es fo
r can
cer r
esea
rch
4.2.
1PB
.181
9.EN
V.07
Cont
ribut
e to
adv
ance
d bi
osta
tistic
al a
nalys
es a
nd d
evel
opin
g bi
osta
tistic
al m
etho
dsPB
.181
9.IC
E.03
Impr
ovin
g st
atist
ical m
etho
ds a
nd m
odel
s to
est
imat
e in
fect
ion-
asso
ciate
d ca
ncer
s PB
.181
9.NM
B.01
Inte
grat
ion
of li
fest
yle a
nd –
omics
-bas
ed e
xpos
ures
in a
etio
logi
cal m
odel
s fo
r can
cer r
esea
rch
4.2.
2Im
prov
e an
d im
plem
ent l
abor
ator
y m
etho
dsPB
.181
9.BM
A.02
Met
abol
omics
-bas
ed d
evel
opm
ent o
f bio
mar
kers
of f
oods
, foo
d co
nstit
uten
ts, f
ood
cont
amin
ants
and
m
etab
olism
PB.1
819.
EGE.
03Ep
igen
omic
prof
iling
appl
icabl
e to
mol
ecul
ar e
pide
mio
logy
PB.1
819.
GCS.
02No
n-in
vasiv
e bi
omar
kers
for e
arly
dete
ctio
n of
can
cer
PB.1
819.
MM
B.03
Expe
rimen
tal m
etho
dolo
gies
and
bio
info
rmat
ic re
sour
ces
for m
olec
ular
can
cer r
esea
rch
PB.1
819.
NEP.
02No
vel t
ools
and
plat
form
s fo
r nut
ritio
n as
sess
men
t in
canc
er e
pide
mio
logy
4.3
4.3.
1De
velo
p an
d m
aint
ain
rese
arch
pla
tform
sPB
.181
9.GE
P.03
Coor
dina
tion
of la
rge
coho
rt st
udie
s as
rese
arch
pla
tform
sPB
.181
9.LS
B.01
Man
agem
ent o
f IAR
C bi
oban
k an
d pr
e-an
alyt
ical p
roce
ssin
g se
rvice
sPB
.181
9.LS
B.03
Capa
city
build
ing
and
biob
ank
infra
stru
ctur
e su
ppor
t for
Low
and
Mid
dle
Inco
me
Coun
tries
(LM
IC)
4.3.
2De
velo
p an
d m
aint
ain
labo
rato
ry a
nd c
ompu
ting
serv
ices
PB.1
819.
GCS.
03Ge
netic
s Pl
atfo
rmPB
.181
9.LS
B.02
Labo
rato
ry S
ervic
es s
uppo
rtPB
.181
9.LS
B.04
Hist
olog
y la
bora
tory
PB.1
819.
MM
B.04
The
IARC
TP5
3 Da
taba
sePB
.181
9.SS
R.03
Labo
rato
ry a
nd c
ompu
ting
serv
ices
4.3.
3Re
spon
d to
em
ergi
ng re
sear
ch o
ppor
tuni
ties
and
dem
ands
by
supp
ortin
g ne
w o
r ong
oing
initi
ative
sPB
.181
9.DI
R.03
Stra
tegi
c Re
sear
ch In
vest
men
t
5 5.1
Defin
e th
e vis
ion
and
impl
emen
t the
scie
ntifi
c st
rate
gy o
f the
Ag
ency
, pro
vidin
g th
e fra
mew
ork
for t
he fu
lfilm
ent o
f its
obj
ectiv
es5.
1.1
Defin
e th
e vis
ion
and
impl
emen
t the
scie
ntifi
c st
rate
gy o
f the
Ag
ency
, pro
vidin
g th
e fra
mew
ork
for t
he fu
lfilm
ent o
f its
obj
ectiv
es
PB.1
819.
DIR.
01Di
rect
ion
and
Lead
ersh
ip
5.2
Over
see
the
stra
tegi
c di
rect
ion
of th
e Ag
ency
and
the
impl
emen
tatio
n of
its
prog
ram
me
5.2.
1Ov
erse
e th
e st
rate
gic
dire
ctio
n of
the
Agen
cy a
nd th
e im
plem
enta
tion
of it
s pr
ogra
mm
ePB
.181
9.SS
R.05
Supp
ort t
o Go
vern
ing
and
Scie
ntifi
c Co
uncil
mee
tings
and
inte
ract
ions
with
Par
ticip
atin
g St
ates
5.3
Crea
te a
nd m
aint
ain
key
stra
tegi
c pa
rtner
ship
s w
ith n
atio
nal,
regi
onal
and
inte
rnat
iona
l org
aniza
tions
5.3.
1Cr
eate
and
mai
ntai
n ke
y st
rate
gic
partn
ersh
ips
with
nat
iona
l, re
gion
al a
nd in
tern
atio
nal o
rgan
izatio
nsPB
.181
9.DI
R.02
Stra
tegi
c Pa
rtner
ship
s
5.4
Effe
ctive
ly co
mm
unica
te a
nd d
issem
inat
e th
e w
ork
of th
e Ag
ency
5.4.
1Ef
fect
ively
com
mun
icate
and
diss
emin
ate
the
wor
k of
the
Agen
cyPB
.181
9.CO
M.0
1In
form
atio
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Scientific Council SC/53/9 Rev.1 Proposed Programme and Budget 2018–2019 (Revision 1) Page 39
WHO
's %
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ntrib
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roup
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ates
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SC/53/9 Rev.1 Scientific Council Page 40 Proposed Programme and Budget 2018–2019 (Revision 1)
Appr
oved
Bu
dget
20
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9%
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494,
554
11,
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324
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461
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316
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1654
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494,
554
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517,
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22,6
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4799
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rman
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580
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ased
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Scientific Council SC/53/9 Rev.1 Proposed Programme and Budget 2018–2019 (Revision 1) Page 41
Leve
l 2Le
vel 2
Obj
ectiv
esRE
GULA
R BU
DGET
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RESO
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Decr
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1.1
Impr
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18
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11
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Supp
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form
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2.1
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167,
595
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383
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200
111,
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419,
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27,3
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26,6
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53,9
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reve
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nce
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2,22
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7
45
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7
14
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06,5
0836
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nce
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ntio
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69
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225
77
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3,77
4,10
3
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4,48
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3
45
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9266
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117,
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2,97
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4
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1,63
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814
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pact
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genc
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cont
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and
impl
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t the
scie
ntifi
c st
rate
gy o
f the
Age
ncy,
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vidin
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e fra
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000
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c di
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e Ag
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tatio
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179,
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5.3
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SC/53/9 Rev.1 Scientific Council Page 42 Proposed Programme and Budget 2018–2019 (Revision 1)
Information Table G PRIORITY PROJECTS REQUIRING ADDITIONAL VOLUNTARY CONTRIBUTIONS
1. Global Initiative for Cancer Registry Development (GICR) Project Tree Path: 1.2.1
Project summary
Demographic transitions are projected to place the greatest future burden of cancer in LMICs. To mitigate the impact, effective evidence-based cancer control programmes are needed. High-quality population-based cancer registries (PBCR), the basis from which to plan, implement and monitor such programmes, are established in less than one-third of all LMICs. Led by the Agency, the GICR is a collaboration with key international partners to accelerate improvements in the coverage, quality and use of PBCRs worldwide to better inform cancer control.
The GICR aims to contribute to the development of in-country capacity for cancer surveillance through structured support to PBCRs. Coordinated by IARC, six IARC Regional Hubs serve as a first point of contact to provide technical training, consultancies through site visits, mentorship and analysis to produce scientific and policy reports. The GICR represents an expansion of activities that have been, and remain, a cornerstone of the Agency since its inception, yielding cancer indicators and fostering descriptive epidemiologic research.
Resource Gap
The total resource gap for the GICR project during the biennium 2018–2019 is approximately €5.98 million. The GICR Secretariat at IARC has overall responsibility for coordinating activities, ensuring progress and communicating with stakeholders, together with providing technical support to the Regional Hubs and target countries. To support these functions during the biennium 2018–2019, €1.64 million for core infrastructure costs and operations of the Hubs is requested. Additional funding mechanisms will be mobilized from other sources to support the country-led surveillance plans over the period, amounting to €4.34 million.
Expected deliverables in 2018–2019 (conditional on available resources)
• Agreements to provide measurable improvements in the coverage, quality and national networking capacity of cancer registries in at least 20 LMIC;
• Transition of a centralized training and support model to one which is devolved into regions through the expanded presence of the six IARC Hubs;
• Launch of a best practices portal and the production of e-learning tools tailored to support PBCRs in LMIC.
These activities will have major impact in targeted LMICs in terms of an increase in the numbers of qualified registry staff working in PBCRs and improvement of the quality of the data on cancer. Ultimately the GICR will increase the accessibility of robust cancer data for national health care planning, monitoring and evaluation, as well as ensure valid national estimates of cancer burden are publicly available.
Scientific Council SC/53/9 Rev.1 Proposed Programme and Budget 2018–2019 (Revision 1) Page 43
Information Table G PRIORITY PROJECTS REQUIRING ADDITIONAL VOLUNTARY CONTRIBUTIONS
2. IARC Monographs Programme Project Tree Path: 2.3.1
Project summary
The IARC Monographs Programme was created in 1971 with the overall aim of providing authoritative, up-to-date evaluations of agents and exposures that present carcinogenic hazards to humans. The hazards that may be evaluated include chemical, physical and biological agents, occupational exposures, complex mixtures, foods, drugs and personal habits. About 1000 such agents have been evaluated to date. The Monographs are respected as a definitive international reference for cancer hazard evaluation. The results are disseminated worldwide and are used by national and international health agencies to support actions to control exposure to known and suspected carcinogens. The Programme’s objective of identifying the causes of cancer is directly relevant to the Agency’s core mission.
Resource Gap
The Monographs Programme is developing a more quantitative approach to hazard evaluation based on advice from a 2014 Advisory Group. Selected Monographs for agents with an adequate database will include quantitative risk estimates within the limits of published data.
To support this approach, the Monographs Section will recruit a scientist with expertise in quantitative exposure assessment. This individual will have operational responsibility for the section covering exposure data in each Monograph, including: managing exposure databases; supporting expert Working Groups in finding and analysing pertinent exposure data and reviewing and fact-checking draft reports. Adding a staff scientist with expertise and responsibilities dedicated to exposure assessment will support the use of quantitative approaches. Along with gains in efficiency, this expansion of the scientific staff together with investment in an additional half-time scientific editor will shorten the time interval from the conclusion of an evaluation to the publication of the final Monograph. The total cost of the additional 1.5 posts is approximately €0.42 million for the biennium.
Expected deliverables in 2018–2019 (conditional on available resources)
The activities of the new staff members would be fully integrated with the overall goals of the programme, which has the following major deliverables for the biennium:
• Convene 5 evaluation meetings with Monograph Working Groups; • Convene an Advisory Group on Priorities to review agents for possible future evaluations; • Publish 6 Monograph volumes.
This request supports ongoing efforts to diversify the funding base for the Monographs programme. Currently, the programme relies on approx. €0.88 million of extrabudgetary resources per year in addition to funds from the regular budget. In view of the worldwide impact of the Monographs and their centrality to IARC’S mission, it is a high priority to expand beyond the single large grant that currently supports a significant proportion of the costs for staff and programme operations.
SC/53/9 Rev.1 Scientific Council Page 44 Proposed Programme and Budget 2018–2019 (Revision 1)
Information Table G PRIORITY PROJECTS REQUIRING ADDITIONAL VOLUNTARY CONTRIBUTIONS
3. Multicentric study of cervical cancer screening and triage with human papillomavirus testing (ESTAMPA)
Project Tree Path: 3.1.2
Project Description
ESTAMPA is an international effort in Latin America to implement organized HPV-based cervical screening and reduce cervical cancer mortality among women in the region, by evaluating emerging screening techniques that can be used to triage HPV positive women and different approaches to implement organized HPV-based screening in the region.
Approximately 50 000 women aged 30–64 years will be HPV-screened in 10 countries in Latin America. The study will provide important data to define triage methods to select women who require further evaluation or treatment among those who are HPV positive, in order to maximize impact of the screening process avoiding excessive diagnostic workup and overtreatment. This will increase the feasibility of the programmes in LMICs. The implementation research components of the study will guide the introduction of HPV-based programs in the region, and the creation of an extensive network of cancer investigators throughout Latin America is expected to lead to new initiatives to develop research in the region. All these activities are fully in line with IARC’s principles and objectives.
Resource Gap
The overall study budget for 2016–2020 is €15 million which is funded mainly from several grants from public funding agencies in the participating countries, the Reproductive Health Research Program of WHO, a grant from the US National Cancer Institute, the UICC and PAHO, as well as from in-kind contributions of the local governments and universities participating in the study. The additional contribution mentioned below will accelerate the programme, including the evaluation of new biomarkers and approaches for cervical cancer control and consolidate the wide network of investigators in the region.
The total voluntary contribution required during the period 2018–2019 to complete the planned activities is €2 million.
Expected deliverables in 2018–2019 (conditional on available resources)
• Consolidation of data and biospecimen bank for evaluation of cervical cancer screening and triage methods
• Realization of field work for sub-study on psychosocial impact of HPV testing • Evaluation of alternative implementation strategies (e.g., invitation for self-collection) in selected
study sites • Design of the ESTAMPA prospective cohort study (5 year follow-up)
Scientific Council SC/53/9 Rev.1 Proposed Programme and Budget 2018–2019 (Revision 1) Page 45
Information Table G PRIORITY PROJECTS REQUIRING ADDITIONAL VOLUNTARY CONTRIBUTIONS
4. Cancer Screening in Five Continents (CanScreen5) Project Tree Path:
3.2.1
Project summary
CanScreen5 will be a global repository of information on cancer screening programs. The project aims to collect, analyze and disseminate information on the characteristics, performance and effectiveness of screening programs worldwide. This will result in improvements in countries in screening programme management and quality assurance, strengthening health information systems, and ultimately to support the collection of screening data and promoting their use informing policy development and research in cancer prevention and early detection.
The methodology will be based on the Agency’s recent experience compiling the European Screening Report on the status of implementation of cancer screening programmes in the EU. The data collection tools and the data management and analysis plan will be further improved to make them more broad based and suitable for different resource settings. An online platform similar to “Cancer Today” in the IARC Global Cancer Observatory will be developed, to disseminate results in a manner suitable for policy makers, programme managers and researchers.
Resource Gap
CanScreen5 will be a long term project of the Agency, requiring standardization of data collection and analysis from many countries with different levels of health system organization. The total budget needed to complete the project is estimated at around €3.0 million, with the amount required for the first phase during 2018–2019 estimated at €1.2 million.
Expected deliverables in 2018–2019 (conditional on available resources)
• Development of tools and guidelines to collect and share data on screening programmes; • Collection and analysis of data and quantitative information on the protocols, management and
performance of screening programs from at least 50 countries in the first phase; • Developing capacity for data collection on screening programs in the selected countries; • Functioning website for data collection and an online platform for dissemination of information
tailored to the needs of various users.
CanScreen5 will be a powerful tool providing access to standardized, systematically collected data and indicators evaluating the performance of cancer screening programmes, eventually in every country where they exist. In addition, it is expected that the project will have an impact in the countries by providing the tools and encouraging them to improve data collection through the development of the health information system for quality assured cancer screening programs.
SC/53/9 Rev.1 Scientific Council Page 46 Proposed Programme and Budget 2018–2019 (Revision 1)
Information Table G PRIORITY PROJECTS REQUIRING ADDITIONAL VOLUNTARY CONTRIBUTIONS
5. IARC Handbooks of Cancer Prevention (HCP) Project Tree Path:
3.3.1
Project summary
The IARC Handbooks of Cancer Prevention evaluate what are the effective interventions and strategies in cancer prevention, following the same rigorous process as the Monographs. IARC Handbooks have evaluated chemo-preventive agents, individual strategies, cancer screening, and tobacco control policies. The Handbooks support the WHO Global Action Plan on the Prevention and Control of Noncommunicable Diseases. Availability of an international consensus from an independent, specialized Agency within the UN family provides an authoritative basis for health agencies to plan and implement their preventive strategies, and should facilitate national recommendations and communication with the population at risk. Conducting evidence-based evaluations of primary and secondary interventions and strategies to prevent cancer is central to IARC’s mission.
Resource gap
Since their re-launch in 2014, Handbooks have been scheduled every 18 months on average, with very limited resources, and support from the staff of the Monographs Programme. Our aim is to secure sustainable, long-term funding dedicated to the Handbooks, to build the sustainability of the programme, and increase staff with the aim to publish one Handbook per year.
The total cost of one Handbook is of €0.52 million – the funding required for the biennium 2018–2019 amounts therefore to €1.04 million.
Expected deliverables for 2018–2019 (conditional on available resources)
• Publication of IARC Handbook Vol. 17 on colorectal cancer screening; • Publication of IARC Handbook Vol. 18 (topic to be decided).
Scientific Council SC/53/9 Rev.1 Proposed Programme and Budget 2018–2019 (Revision 1) Page 47
Information Table G PRIORITY PROJECTS REQUIRING ADDITIONAL VOLUNTARY CONTRIBUTIONS
6. IARC Fellowship Programme Project Tree Path:
4.1.1
Project summary
For five decades as a core statutory function of the Agency, the Fellowship Programme has contributed to the development of human resources for cancer research worldwide. The main goal of the Programme is to provide training in cancer research in areas relevant to the Agency’s programme. Ultimately, the Fellowship Programme also aims at catalysing the creation of collaborative links between IARC, cancer researchers, and research institutes. Although all countries have been targeted in recent years, a specific focus has been on LMICs.
IARC Postdoctoral Fellowships represent the vast majority of awards through the Programme. This scheme targets early career scientists, offering two-year fellowships uniquely tenable at IARC. Fellows from LMICs can apply for a return grant, supporting the establishment of their research activity in their home country. The Programme also attracts senior visiting scientists through a dedicated Award, to participate in collaborative research projects at the Agency. Finally, short fellowships have also been established in relation with the IARC Summer School.
Resource gap
Funding allocated to the Programme under the proposed regular budget for 2018–2019 is €0.86 million, which will allow the award of 11 two-year Postdoctoral Fellowships over the biennium (this includes the additional extraordinary contribution of €80 000 mentioned under Objective 4 of the Programme). In the past seven years, additional extrabudgetary funding was secured through two consecutive EC MSCA FP7-COFUND grants, complemented with bilateral agreements with Cancer Council Australia and the Irish Cancer Society. The funding from the COFUND programme allowed the award of around eight additional two-year Postdoctoral Fellowships per biennium. In 2015, IARC submitted a new application under the EC MSCA H2020-COFUND-2015 call for which the Agency was deemed ineligible.
The objective being to maintain the number of fellowships awarded, a shortfall of €0.56 million need to be secured over the biennium through alternative sources of funding.
Expected deliverables in 2018–2019 (conditional on available resources)
• Eighteen two-year IARC Postdoctoral Fellowships awarded over the biennium;
• Partnerships set up in order to develop additional bilateral Postdoctoral Fellowships;
• Four short-term Fellowships awarded every year;
• Two Senior Visiting Scientist Awards each year.
This additional funding would ensure that the number of training opportunities for early career scientists are maintained, and that IARC can pursue its mission to contribute the development of new generations of cancer researchers, especially in LMICs.
SC/53/9 Rev.1 Scientific Council Page 48 Proposed Programme and Budget 2018–2019 (Revision 1)
Information Table G PRIORITY PROJECTS REQUIRING ADDITIONAL VOLUNTARY CONTRIBUTIONS
7. IARC “Nouveau Centre” Plus Project Tree Path:
6.1.1
Project summary
The Nouveau Centre is a major building infrastructure project at the core of IARC’s global research mission for the next 30 to 50 years. The new building is an integral part of IARC’s business continuity plan, ensuring building infrastructure security in the long term.
The design and construction phase of the new IARC building, to be located in the Gerland bio-district area of Lyon, is overseen by the Métropole de Lyon in cooperation with other French authorities. The project started in 2011, in close collaboration with local partners, and should be completed in 2021 when IARC moves to its new premises. The budget for the Nouveau Centre core project amounts to €49.26 million (as of July 2016) funded by the French authorities, which covers building costs, and partially covers infrastructure and equipment costs.
Apart from coordinating and assisting the Métropole de Lyon in the daily management of the project, IARC is required to finance and manage the design and installation of offices, meeting rooms and public facilities, the partial renewal of IARC’s scientific equipment, and the physical move to its new premises. IARC will also take advantage of this important opportunity for modernization to create a fully enabling working environment for its personnel. These activities are not covered in the above quoted budget for the Nouveau Centre core project.
Resource gap
The additional costs to fully complete the move and installing IARC in the new premises is conservatively estimated at €7.78 million. IARC management pledged to set aside €1.5 million from overheads earned over the five year period of 2015–2019 to partially cover the physical move. The City of Lyon will provide €1.2 million from sales proceeds of the Latarjet and BRC buildings to be utilized to partially cover office design and installation costs. Residual balance of funds approved by the GC for legal services related to the Nouveau Centre project (Resolution GC/54/R6) and anticipated revenue from sales of old furniture and equipment will further contribute to cover these expenses. Nonetheless, the remaining unfunded balance of €5.04 million will be required to be mobilized over the next five year period of 2017–2021, with a target of €2.52 million for the 2018–2019 biennium.
Expected deliverables (conditional on availability of resources)
• Design and installation of offices, meeting rooms and ITC infrastructure (€0.94 million)
• Strengthened security measures, appropriate public facilities and internal building infrastructure (€0.86 million)
• Newly installed automated biobank and laboratory facilities (€2.70 million)
• Smooth transition and seamless physical move to the new premises (€0.54 million)
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