project background & lessons learned pascal vuilleumier, md
Post on 18-Jan-2018
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Project Background &
Lessons Learned
Pascal Vuilleumier, MD
No conflicts to declare
Who I am?
• Attending Anesthesiologist in University Hospital Bern, Switzerland
• Staff in level 1 trauma and transplant center• Mainly digestive, oncologic, thoracic and
gynecologic anesthesia • Research in spinal pain modulation on a Swiss
National Grant for 3 years. Leading current projects in volunteer studies within Gaba & Oxytocin receptors, EEG and pain.
And why I came to UWMC• Learn and understand research on genetics of
pain• Perform a prospective study in Brazil in the
Women’s Hospital of Santa Johana, in Sao Paulo, on the effects of low dose gabapentin and ketamine on post cesarean pain
• Data analysis on oxytocin receptor genotype and haplotype and post-cesarean pain
OB Fellowship
• A good opportunity to see how others do & perform
&• An excellent opportunity to combine my
primary aim of research with protected research time and a clinical commitment allowing a salary that is adequate to feed and house my wife and now 2 kids
Current picture of the projects
• Brazil: First study protocol written 12.2011, but considered too complex after my fellowship started. A second study protocol was written and complete by 11.2012 , nevertheless unknown issues seem to delay study start to unknown date.
• My clinical commitment seems to make this project impossible to pursue.
Current picture of the projects
• Promise to perform QST measures in regard to opiate hyperalgesia with human volunteers in a project in preparation by Dr. P. Richebe in replacement of the Brazil study
• Philippe Richebe decided to resign his position at UWMC in early 02.2013
Current picture of the projects
• Oxytocin receptor and post cesarean pain: Abstracts accepted for the SOAP congress and for ASA. Major issues with data quality with > 35% of missing results, making statistic analysis challenging. Data is back in Singapore, where it originated, to be reanalyzed by local statistician in possession of complete database.
• Outcome, results and publication ?
Current picture of the projects
• Book chapter on post partum hemorrhage written, third author
• Which book it was for remains unknown
Current picture of the projects
• Review article on pain after delivery written, third author
Current picture of the projects
• Small analysis on post IVF pain and plasmatic estradiol levels (n=9, now n=16).
• Positive correlation found, presented as poster at the SOAP congress and the UW academic evening.
• Third place award for excellence in research received
• Manuscript in preparation
Current picture of the projects• Epigenetic impact of in utero exposure to opiates in
the generation Z’• Project defined as faculty fellow project Sept. 2012• Submitted in my name for a SOAP grant, not received• Submitted for ITHS grant, approx 15000 USD awarded
to Dr. R. Landau• Genetic samples were analyzed in July; results, data
analysis and manuscript preparation handed over to a medical student
Lessons learned• Proper preparation prevents poor performance– Have one or several study protocols ready for IRB
submission when starting in your new position– Timing is of prime importance: IRB approvals, grant
submissions, writing good study protocols are all extremely time-consuming
– If not properly prepared with grants and IRB submissions prospective studies may need 6-12 months to be on track
Lessons learned• Trust your “gut feeling”– Your mentor is of prime importance to complete a
study– Your mentor has to know you, be one of your
closest allies, confident and guide, in professional and sometimes also private matters
– If there is no professional “love story” there may be difficulties
Lessons learned
• Protected research time
– Is not every week after a 24h call– Is not good-will time that is offered to you out of
human generosity
• If you are called in clinic just anytime you perform research duties: you will perform poorly in research
Lessons learned
• No study without grants– Trust your future to groups that have shown
excellence in research; – in the US NIH granted groups are the benchmark– Industry or other sponsors are also a good
alternative, but there needs to be proper funding for what you aim to study is
Lessons learned
• Why and what to study?– Continuity, personal interests, anesthesia practice
• What are your aims?– Academic career vs private practice
• In what does research help in/for your future?– Ranking of publications– Prospective studies vs retrospective data analysis– Original pubications vs reviews
Conclusions• Research needs a huge investment in time,
energy, preparation and patience• To trust is ok, to control is better• Chose your mentor with care in regard to
personality, availability, past publications and received grants
• Have an aim, and pursue this aim, don’t challenge your aim every other week
Conclusions
• The academic way is long & difficult; fences and obstacles in research are increasing and will be your daily life
• Do never neglect other really important things in life; without family and/or friends human beings do not survive and perform well on the long run
Thank you&
Good Luck!
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