prevalence of helicobacter pylori infection in chronic dyspeptic patients with peptic ulcer in...

Prevalence of Helicobacter pylori infection in chronic dyspeptic patients with peptic

ulcer in Naresuan University Hospital

Researchers

Rutnumnoi Thanachat 52460390Ridamrong Waraporn 52460888

Advisors

Jiratwang Manatchanok, MD.Lertkajornsin Suwit, MD.

Background

Helicobacter pylori• Gram-negative, curved S-shaped, microaerophilic

bacterium• Most common cause of gastritis, peptic and

duodenal ulcers and gastric adenocarcinoma

Objectives

• To find out the prevalence of H. pylori infection in chronic dyspeptic patients with peptic ulcer.

• To explore the relationship between the characteristics of ulcer and the H. pylori infection.

Method• A cross-sectional descriptive study was performed

by collecting data in EGD clinic, Naresuan University hospital during October 2004 to August 2012.

• The diagnosis of Helicobacter pylori infection was done by Rapid Urease Test and Histological examination.

• Stataversion12 was used to conclude the information.

Method

• Inclusion criteria– Patients with dyspepsia which had been

diagnosed by a specialist.– Patients who underwent upper gastrointestinal

endoscopy clinic at Naresuan University Hospital with indication of Dyspepsia.

– Patients with Helicobacter pylori infection results diagnosed by Rapid Urease Test and / or Histological Examination.

Method

• Exclusion criteria– Patients with other indications for upper

gastrointestinal endoscopy beyond dyspepsia.– Patients who were diagnosed as Helicobacter

pylori infection by both Rapid Urease Test and Histological Examination.

MethodChronic dyspeptic patients who underwent the EGD at

NUH during Oct 2004 to Aug 2012

53 patients

Results

Variables

2004 2005 2006 2007 2008 2009 2010 2011 2012 Total

Sex

Male 1 6 3 2 2 4 0 4 3 25

Female 1 3 4 1 6 3 4 2 4 28

Age

Min 58 43 45 53 51 51 47 65 61

Max 74 77 74 77 77 85 59 81 83

Mean 66.00 52.22 57.14 64.67 64.50 66.29 52.25 70.83 70.29 62.81

SD 11.31 10.12 11.14 12.01 9.23 11.46 5.74 6.52 7.16 10.82

Table 1 : Demographic data of chronic dyspeptic patients with peptic ulcer who underwent EGD at NUH between Oct 2004 – Aug 2012.

Results

7.55%

90.57%

1.88%

Bar graph 1 : Endoscopic findings of Chronic dyspeptic patients with peptic ulcer who underwent EGD at NUH between Oct 2004 – Aug 2012.

Results

66.04%

33.96%

Bar graph 2 : Rapid urease test results for detection of Helicobacter pylori infection in Chronic dyspeptic patients with peptic ulcer who underwent EGD at NUH between Oct 2004 – Aug 2012.

Results : Bar graph 3

66.67%

33.33%

Bar graph 3 : Histological examination results for detection of Helicobacter pylori infection in Chronic dyspeptic patients with peptic ulcer who underwent EGD at NUH between Oct 2004 – Aug 2012.

Results

Endoscopic Findings

Rapid Urease Test Results Total P Value0.275

H. pylori Positive

(n)

H. pylori Positive

(%)

H. pylori Negative

(n)

H. pylori Negative

(%)

GU 15 31.25 33 68.75 48

90.57

DU 2 50.00 2 50.00 4

7.55

GU + DU 1 100.00 0 0.00 1

1.89

Total 18 33.96 35 66.04 53

Table 2 : The relationship between Rapid urease test results for detection of Helicobacter pylori infection in Chronic dyspeptic patients who underwent EGD at NUH between Oct 2004 – Aug 2012. and endoscopic findings

Results

Endoscopic Findings

Histological Examination Results Total P Value0.667

H. pylori Positive

(n)

H. pylori Positive

(%)

H. pylori Negative

(n)

H. pylori Negative

(%)

GU 5 62.50 3 37.50 8

88.89

DU 1 100.00 0 0.00 1

11.11

GU + DU - - - - -

Total 6 66.67 3 33.33 9

Table 3 : The relationship between Histological examination results for detection of Helicobacter pylori infection in Chronic dyspeptic patients who underwent EGD at NUH between Oct 2004 – Aug 2012. and endoscopic findings

Results

Total Notes

Patients 53 -

Rapid Urease Test

Positive

18 -

Histological Examination

Positive

6 Histological Examination Positive with

Rapid Urease Test Positive

4

Only Histological Examination Positive

2

The prevalence was 37.74 % (20 of 53 patients)

Table 4 : The prevalence of Helicobacter pylori infection in patients with Chronic dyspeptic patients with peptic ulcer who underwent the EGD at NUH between October 2004 - August 2012.

Conclusion

• The prevalence of H. pylori infection was still high in the chronic dyspeptic patients with peptic ulcer.

• This may relate to GU, DU and combined GU and DU.

• There was no significant difference in relationship between endoscopic findings and Helicobacter pylori infection which detected by Rapid urease test or Histological examination.

THANK YOU