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Pough Appendix 1

1

Biomedical Application of Cladistics

SARS (Sudden Acute Respiratory Syndrome) virus

Virion = nucleocapsid+ viral RNA withoutlipid membrane.

Corona virus

fig 13.4

1. Viral glycoproteins bind toreceptors on the host cellmembrane.

2. Virus enters cell byendocytosis.

3. Viral RNA is released4. Viral RNA makes viral

mRNA

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3

4

fig 13.4

5. Viral RNA makes more viralRNA

6. Viral RNA is translatedinto viral proteins

7. The virion is assembled7

65

fig 13.4

8. Viral envelopeglycoproteins are made onhost ER and transported tothe cell membrane via theGolgi apparatus.

9. New viruses are assembledby budding and arereleased.

8

6

fig 13.4

8. Viral envelopeglycoproteins are made onhost ER and transported tothe cell membrane via theGolgi apparatus.

9. New viruses are assembledby budding and arereleased.

8

6

fig 13.4

• Virus RNA replication isprone to error (pointmutations).• So viruses evolve rapidly.• Origin of a new pathogenicvirus can be determined byanalyzing base sequences.

fig 13.4

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