plegable biology 2
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SNEIDER ALEXANDER TORRES SOTO BIOLOGY MOLECULARUPB-MEDELLIN
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The cytogenetics is the study of chromosomes in number and in structure,
The main technique for human cytogenetics study is represented by fluorescence in situ hybridization (FISH), which is considered a technique that revolutionized the chromosome analysis in human cytogenetics and emerges as a promising technique in the field clinicalgenetics, clinical oncology and clinical researchs.
The investigation is to
ascertain whether the
suppression of
chromosome 9p in clear
cell renal carcinoma
(ccRCC) predicts worse
disease-specific survival
(DSS).
When you
suppress the
chromosome 9p it
stops removing
large tumors,
creating a greater
likelihood of
having a high
tumor
classification.
Chromosome 9p.
http://dermatology.cdlib.org/
Deletion of chromosome 9p confers a
worse prognosis independent in patients
with localized disease ccRCC, and most
notably, in patients with localized mass,
small kidney
Histological appearance of renal cell carcinoma the identification of
patients with 9p
deletions improve risk
stratification and help
select appropriate
patients for surveillance
protocols or aggressive
treatment.
http://escuela.med.puc.cl
I think that this study has great clinical
application, since it allows to determine
which patients are at high risk of
developing renal cancer and through
this to prevent decreasing the morbidity
and mortality.
long arm of
chromosome 20 is an
abnormality of acute
myeloid leukemia
(AML)and
myelodysplastic (MDS)
syndrome and is
presumed to cause the
loss of a tumor
suppressor gene in the
20q12.
Additional copies of chromosome 20
may generate an amplification of the
regions of the chromosome where the
gene suppressor as in a translocation.
By RT-PCR has shown a correlation
between amplification and increased
expression of gen.
Localized and high-level amplification of
the 250 kb region common is a test for
the activation of an oncogene in this
region in these cases of MDS and AML.
20q11.21 amplified
cases tended to
have a high
proportion of
erythroblasts in the
bone, with two
cases diagnosed as
erythroleukemia
Suppressor gene inactivation
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from my point of view this investigation
allows for a more information about
acute myeloid leukemia resulting in a
better perspective on this and be able to
act at the site of the error causing a possible diagnosis.
Cytogenetic is the branch of genetic that
studies the diseases of chromosomal inheritanc.
The cytogenetic allows determining the
type of chromosomal abnormality is a
diagnostic tool that allows confirmation
of the diagnosis of such diseases and
also the proper genetic counseling of
patients and their families ;.
The cytogenetic in the cancer represents
and avvantadge for a rapid prevention
of many diseases, including cancer
recurrent recurring chromosome in
certain malignant tumors
the cytogenetics plays an important role
in these two aforementioned
pathologies such as leukemia, renal
carinoma mieloidy and enabling you to
identify genetically affected site and
provides a pattern in their evolution.
MARTINEZ SÁNCHEZ, Lina María.
Biología molecular. 5. ed. Medellín:
UPB. Fac. de Medicina, 2009. 71-72 p.
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