performance, safety, garantee of results isagro spa – product development
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Performance, safety, garantee of results
Isagro SpA – Product Development
ISAGRO S.p.A - Product Development
DOMARK is formulated as an emulsifiable concentrate (EC), that is a liquid formulation forming an emulsion after dilution in water
Solvent based formulation where the active ingredient TETRACONAZOLE is dissolted in organic solvents, nonilphenols free, favouring its penetration and biological activity
Excellent stability when stored at either high or low temperatures
FORMULATIONFORMULATION
ISAGRO S.p.A - Product Development
a broad spectrum systemic triazole fungicide discovered bya broad spectrum systemic triazole fungicide discovered by
Tetraconazole is ISAGRO’s proprietary molecule
At present more than 140 registrations have been obtained in 60 countries and others are pending
TETRACONAZOLETETRACONAZOLE
ISAGRO S.p.A - Product Development
TECHNICAL FEATURESTECHNICAL FEATURESTECHNICAL FEATURESTECHNICAL FEATURES
• Common name: tetraconazole• Chemical class: triazoles• Mechanism of action: IBS – Sterol Biosynthesis Inhibitor• Mode of action: systemic fungicide
• Common name: tetraconazole• Chemical class: triazoles• Mechanism of action: IBS – Sterol Biosynthesis Inhibitor• Mode of action: systemic fungicide
ISAGRO S.p.A - Product Development
Tetraconazole, among all the triazoles, is the compound with the best balance between hydrosolubility and liposolubility and thanks to this property it ensures:
Swift penetration and traslocation within the plant
Translaminar movement
Systemicity through the upward lymphatic stream
Homogeneous distribution inside the plant without local
accumulation
Preventive and curative activity
TETRACONAZOLE DISTRIBUTIONTETRACONAZOLE DISTRIBUTIONTETRACONAZOLE DISTRIBUTIONTETRACONAZOLE DISTRIBUTION
ISAGRO S.p.A - Product Development
Translocation through
the sapHydrosolubility
Liposolubility
Vapour tension
Diffusion through the lipids and the cuticolar waxes
Redistribution on and inside the plant
TETRACONAZOLE DISTRIBUTIONTETRACONAZOLE DISTRIBUTIONTETRACONAZOLE DISTRIBUTIONTETRACONAZOLE DISTRIBUTION
ISAGRO S.p.A - Product Development
Excellent balance between hydrosolubility and liposolubility
156
73
142
32
18
100
140
130
6,63
54
15
Tetraconazole
Penconazole
Myclobutanil
Tebuconazole
Esaconazole
Propiconazole
Cyproconazole
Flutriafol
Epoxiconazole
Flusilazol
Metconazole
Hydrosolubility mg/L
3400
5248
900
5000
79405248
813
200
2754
5500
7079
Kow
TETRACONAZOLE DISTRIBUTIONTETRACONAZOLE DISTRIBUTIONTETRACONAZOLE DISTRIBUTIONTETRACONAZOLE DISTRIBUTION
ISAGRO S.p.A - Product Development
Treated area2 hours
3 days 7 days
14 days
RADIO LABELED MOLECULE IN SUGAR BEET LEAF
RADIO LABELED MOLECULE IN SUGAR BEET LEAF
DISTRIBUTION IN THE PLANTDISTRIBUTION IN THE PLANTDISTRIBUTION IN THE PLANTDISTRIBUTION IN THE PLANT
ISAGRO S.p.A - Product Development
RADIO LABELED MOLECULE IN GRAPE LEAFRADIO LABELED MOLECULE IN GRAPE LEAF
2 hours 3 days
7 days 10 days
Treated area
DISTRIBUTION IN THE PLANTDISTRIBUTION IN THE PLANTDISTRIBUTION IN THE PLANTDISTRIBUTION IN THE PLANT
ISAGRO S.p.A - Product Development
SELECTIVITYSELECTIVITYSELECTIVITYSELECTIVITY
Some important biochemical processes, such as gibberellins and phytosterols synthesis, are regulated by cytochrome - P450 – based enzymes; due to its particular molecular structure tetraconazole does not interfere with these processes but only with the ergosterol biosynthesis of the fungus
No phytotoxic effects on the treated plant have ever been seen
Some important biochemical processes, such as gibberellins and phytosterols synthesis, are regulated by cytochrome - P450 – based enzymes; due to its particular molecular structure tetraconazole does not interfere with these processes but only with the ergosterol biosynthesis of the fungus
No phytotoxic effects on the treated plant have ever been seen
ISAGRO S.p.A - Product Development
TETRACONAZOLE
Germ tube growth
Formation of appressorium
and penetration
Beginning ofmycelial growthand colonization
botrytis_KBR.ppt 08.12.99
Mechanism of ActionMechanism of Action
Colonization of tissues not allowed with TETRACONAZOLE
X
TETRACONAZOLE PREVENTIVE ACTIVITY
ISAGRO S.p.A - Product Development
Beginning ofmycelial growthand colonization
botrytis_KBR.ppt 08.12.99
Mechanism of ActionMechanism of Action
Tetraconazole
Damage already set (colonization of tissues resulting in cell death and necrosis) but stopped with TETRACONAZOLE application
Tetraconazole
Tetraconazole TetraconazoleTetraconazole
Tetraconazole
TETRACONAZOLE CURATIVE ACTIVITY
ISAGRO S.p.A - Product Development
CercosporaBipolarisCercosporaBipolaris
P. Mildew, scab
P. Mildew, scab
RhizoctniaPyriculariaBipolaris
RhizoctniaPyriculariaBipolaris
P. mildewP. mildew P. mildewP. mildew
Sclerotinia, AlternariaSclerotinia, Alternaria
P. mildewalternariaP. mildewalternaria
RustRust
Rust, Cercospora, Septoria
Rust, Cercospora, Septoria
MAIN USES OF TETRACONAZOLECrops and diseases
Rusts, Septoria, P. mildew
Rusts, Septoria, P. mildew
Cercospora, RustP. mildew, Ramularia
Cercospora, RustP. mildew, Ramularia
P. mildewP. mildew
ISAGRO S.p.A - Product Development
» Effective control of several pathogen affecting different crops» Costant performance» Selectivity towards the crop» Inventory optimization
» Effective control of several pathogen affecting different crops» Costant performance» Selectivity towards the crop» Inventory optimization
DOMARK is the solution to farmers and distributor’s needs as it provides:DOMARK is the solution to farmers and distributor’s needs as it provides:
ISAGRO S.p.A - Product Development
Broad spectrum of action Wide window of application Excellent selectivity Great systemicity granting a uniform protection of the crop Good activity as protectant and curative fungicide Effective and safe at either high or low temperatures Low usage rate Versatility/compatibility with other products Environmentally friendly (good eco-tox profile)
ADVANTAGES OF TETRACONAZOLEADVANTAGES OF TETRACONAZOLEADVANTAGES OF TETRACONAZOLEADVANTAGES OF TETRACONAZOLE
ISAGRO S.p.A - Product Development
Thank you for your attentionThank you for your attention
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