percivall pott 1714 – 1788 chimney sweeps cancer of the scrotum pott’s disease – vertebral...

Percivall Pott

1714 – 1788 Chimney sweeps

cancer of the scrotum

Pott’s disease – vertebral tuberculosis

John Hunter

1728 – 1793 Papers at the Royal

Society on experimental pathology, including the use of a microscope

Described inflammation

Hunterian Museum, Royal College of Surgeons, London

First Systematic Textbook of Pathology

Matthew Baillie – 1761 – 1823

Nephew of John Hunter

The Morbid Anatomy of Some of the Most Important Parts of the Human Body

Microscopic pathology atlas

Physician of King George III

Thomas Hodgkin

1798 – 1866 On Some Morbid

Appearances of the Absorbent Glands and the Spleen

“Lister’s compound microscope might lead to useful discoveries in the future.”

Joseph Recamier – 1774 – 1852 – metastasis

Richard Bright – 1789 – 1858 – Kidney disease

Thomas Addison – 1793 – 1860 – Pernicious anemia

Cell Theory

Robert Hooke – 1635 – 1703 – cell

Matthias Jacob Schleiden – 1804 – 1881 – botanist

Theodor Schwann – 1810 – 1882 – zoologist

Cell TheoryJohannes Peter Müller

1801 – 1858 Berlin Father of medical

microscopy Microscopic criteria for

benign and malignant tumors

Über den Feinern Bau und die Formen der Krankhaften Geschwülste – On the Finer Structure and Form of Morbid Tumors

Cell TheoryRudolph Virchow

1821 – 1902 The greatest

figure in the history of Pathology

Die Cellularpathologie

“Omnis cellula e cellula” – all cells from cells

Herman Lebert – 1831 – 1878

Microscopic atlas

1850s

Pathology developed as a separate specialty

Medical schools, Professors of Pathology Microscope, diagnostic histopathology,

neoplasia France – laboratories Germany – universities

Microscope

Fresh tissue, cut by hand, unstained

Formaldehyde fixation – Isaac Blum – 1833 – 1903

Paraffin embedding – Edwin Klebs – 1834 – 1913

Microtome – Minot – 1852 – 1914

Biological stains Hematoxalin – Franz

Böhmer Paul Ehrlich – 1854 – 1915

Anaplasia

David Von Hansemann 1858 – 1920

Grading, Carcinoma in Situ

Albert Compton Broders 1885 – 1964 Mayo Clinic

Staging

Cuthbert Esquire Dukes 1890 – 1977 St. Mark’s

Hospital, London

Pap Smear

George Papanicolaou – 1883 – 1962 January, 1928 – New

Cancer Diagnosis – Betterment Conference Battle Creek Michigan

1941 – The Diagnostic Value of Vaginal Smears in Carcinoma of the Uterus

1943 – Diagnosis of Uterine Cancer by the Vaginal Smear

1954 – Atlas of exfoliative Cytology