outline: 1. match project 2. health implications of pah in indoor environments 3. spade project dr...
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OUTLINE:OUTLINE:
1. MATCH PROJECT
2. Health Implications of PAH in Indoor Environments
3. SPADE PROJECT
Dr Juana Maria Delgado-SaboritDivision of Environmental Health and Risk Management School of Geography, Earth and Environmental SciencesUniversity of Birmingham
OBJECTIVES: Quantify the magnitude and range of individual personal
exposures to a selected group of air toxics (VOC & PAH) Develop models for exposure prediction based on time/activity
diaries and micro-environmental concentrations
MATCH PROJECTMATCH PROJECT- Measurement and modelling of Air Toxic
Concentrations for Health effects and verification by biomarkers
METHODOLOGY: Personal Exposure Sampling Time-Activity Diary Microenvironment Monitoring Biomonitoring Model Development
RESULTS:
MATCH PROJECT
MATCH PROJECT
VOC PERSONAL EXPOSURE AND MICROENVIRONMENT CONCENTRATIONS
0.0
0.1
1.0
10.0
Concentrations (mg / m
3)
PE All Home All Work All Street All
Transport Vehicles All Transport Stations All Pubs and restaurants All Other Indoors All
-2.00 -1.00 0.00
Log 3-Ethenyl Pyridine
0.00
1.00
2.00
R-Square = 0.54
URINARY BIOMARKERS
Benzene Measured10.008.006.004.002.000.00
Ben
zen
e_P
red
icte
d
6.00
5.00
4.00
3.00
2.00
1.00
0.00
R Sq Linear = 0.469
R2=0.47
MODELLING
PERSONAL & MICROENVIRONMENT
PERCENTAGE CONTRIBUTION OF MICROENVIRONMENT TO PE
0
10
20
30
40
50
60
70
80
90
100
n-he
xane
Benze
ne
Tolue
ne
Ethylb
enze
ne
p-Xyle
ne
m-X
ylene
Pyridi
ne
o-Xyle
ne
1,3,5-Trim
ethylb
enze
ne
Styren
e
p-Iso
prop
yltolu
ene
1,2,4-Trim
ethylb
enze
ne
3-Ethe
nylpy
ridine
Naphtha
lene
1,3-Bu
tadie
ne
Per
centa
ge (%
)
OBJECTIVES: Assess typical range concentrations and profile of PAH indoor &
outdoors Assess carcinogenic potency of PAH indoors & outdoors Evaluate whether BaP can be used as a marker indoors
Health Implications of PAH in Indoor Environments
METHODOLOGY: Microenvironment Sampling – Indoors & Outdoors – MATCH Calculate carcinogenic potency (CP) and % contribution of BaP to CP
100)(
)().(%
1
xRCxRP
RCxRPPotencialCarc N
ii
ii
PAHs Abbrev. Potency Benzo[a]pyrene BAP 1.0 Benz[a]anthracene BAA 0.1 Benzo[b]fluoranthene BBF 0.1 Benzo[k]fluoranthene BKF 0.01 Chrysene CHY 0.001 Dibenz[a,h]anthracene DBA 1.0 Indeno[1,2,3-cd]pyrene IDP 0.1
CARCINOGENIC CONTRIBUTION
0.0
10.0
20.0
30.0
40.0
50.0
60.0
Benzo
(a)anthr
acen
e
Chrys
ene
Benzo
(b)flu
oran
then
e
Benzo
(k)fluo
ranthe
ne
Benzo
(a)pyren
e
Inde
no(1,2,3-cd)
pyre
ne
Diben
z(a,h)an
thrace
ne
Carc
inogenic
contrib
ution
Indoors ETS (Pub) Indoors No ETS Outdoors Trafficked Roadside Outdoors Park London 1991-1995 Aluminium Smelter
PAH CONCENTRATIONS
0.0
0.1
1.0
10.0
100.0
Acena
phthyle
ne
Acena
phthen
e
Fluo
rene
Phena
nthren
e
Anthrac
ene
Fluo
ranthe
ne
Pyren
e
Benzo
(a)anthr
acen
e
Chrys
ene
Benzo
(b)flu
oran
then
e
Benzo
(k)fluo
ranthe
ne
Benzo
(a)pyren
e
Inde
no(1,2,3-cd)
pyre
ne
Diben
z(a,h)an
thrace
ne
Benzo
(ghi)
peryl
ene
Coron
ene
Concentr
ations (ng / m
3)
Indoors ETS (Pub) Indoors No ETS Outdoors Trafficked Roadside Outdoors Park
Health Implications of PAH in Indoor Environments
OBJECTIVES: Source apportionment of PAH in ambient air Assess contribution of long-range transport & local sources Study the breakdown rates of PAH in the atmosphere Assess levels of PAH reaction products: quinones
SPADE PROJECTSPADE PROJECT – Sources and Processes determining polycyclic Aromatic hydrocarbons and their Degradation products in the Environment
METHODOLOGY: Gas and Particle phase sampling – PAH & Quinones Remote sampling – HYSPLIT back-trajectories Lagrangian experiment
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