on-off flickering
Post on 03-Jan-2016
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on-off flickering
voltage-dependent block by proton
node of Ranvier
2-barrier model for proton block
well
outside
voltage-dependent block with TEA
K-depolarized squid giant axon
Time course of block by C9
squid giant axon
TTX-blocked iNa
internal C9 0.11 mM (nonyltriethylammonium)
Concentration-dependent block
internal TPeA (tetrapentylammonium)
+ 120 mV
Armstrong’s hypothesis for QA block
QA (quaternary ammonium)
use-dependent block with lidocaine
node of Ranvier, - 20 mV
internal NMS
(N-methylstrychnine)
QX-222 (quaternary lidocaine)
nicotinic AChR
frog sartorius muscle
-125 mV
-150mV
-120mV
-120mV
-150mV
multi-ion block in a long pore
selectivity filer
voltage-dependent multi-ion block
[K]o = 25 mM
flickering block by external Cs+
tunricate egg
Inward rectifier
200 mM [K]o
10 M [Cs]o
Long block dwell times with TTX and STX
batrachotoxin-Na channel, rat brain synaptosomes
symmetrical 200 mM NaCl, +50 mV
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