northwest-alaska pharmacogenomics research network “pharmacogenetics in rural and underserved...
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Northwest-Alaska Pharmacogenomics Research Network“Pharmacogenetics in Rural and Underserved Populations”
Kenneth Thummel1 and Wylie Burke2
Depts. of Pharmaceutical Sciences1 and Bioethics & Humanities2, University of Washington, Seattle, WA
Clinical/Translational
Tamoxifen – CYP2D6 Genotype-Pharmacokinetics (PK) Relationship
(Aim 2A; UM, SCF, UW)
Tacrolimus – CYP3A Genotype-PK Relationship (Aim 2B; UW, SCF, UM)
Warfarin – CYP2C9, CYP4F2, VKORC1, GGCX Genotype-Pharmacodynamic
Relationships (Aim 2C; SCF, UW)
Warfarin – Gene variation penetrance as a function of rural vs. urban INR monitoring
(Aim 4A; GHRI, UW)
Assessment & Capacity Development
Focus groups/consultation with AI/AN community members; health care provider deliberation (Aim 1A; UM, SCF, UAF, UW)
Develop infrastructure to track adverse drug reactions in rural NW/Alaska for
pharmacogenomic studies (Aim 4B; UW ITHS – WWAMI)
Discovery
SNP Discovery – CYP2D6, CYP2C9, CYP3A4, CYP3A5, CYP4F2, VKORC1, GGCX (Aim 1B; UM, SCF, UAF, UW)
Gene-Diet Interactions/Cell-based systems (Vitamin K, PUFAs)
(Aim 3; UAF, UW, PSBC)
People in Rural and Urban Washington and Idaho
Dual Principal InvestigatorsKen Thummel, Wylie Burke
Program CoordinatorBarbara Kavanaugh
Dual Principal InvestigatorsKen Thummel, Wylie Burke
Program CoordinatorBarbara Kavanaugh
University of Washington
Allan Rettie*Dave Veenstra
Dave BloughHelene Starks
Rose James
Mark Rieder, Melissa Austin, Alfred Berg, Kari Stephens, Connie Davis, Ron Whitener
University of Washington
Allan Rettie*Dave Veenstra
Dave BloughHelene Starks
Rose James
Mark Rieder, Melissa Austin, Alfred Berg, Kari Stephens, Connie Davis, Ron Whitener
Center for Alaska Native Health Research (CANHR)
University of Alaska - Fairbanks
Bert Boyer*Scarlett Hopkins
Diane O’Brien
Center for Alaska Native Health Research (CANHR)
University of Alaska - Fairbanks
Bert Boyer*Scarlett Hopkins
Diane O’Brien
University of Montana
Erica Woodahl*Liz Putnam
LeeAnna MuzquizMark Pershouse
Pat Beatty
University of Montana
Erica Woodahl*Liz Putnam
LeeAnna MuzquizMark Pershouse
Pat Beatty
ResourcesGene Resequencing CenterFunctional Genomics LabMass Spectrometry Center
ResourcesGene Resequencing CenterFunctional Genomics LabMass Spectrometry Center
Southcentral Foundation
Denise Dillard*Douglas Eby
Brian Schilling
Southcentral Foundation
Denise Dillard*Douglas Eby
Brian Schilling
ResourcesAlaska Stable Isotope Facility
CANHR Culture Intervention Core
ResourcesAlaska Stable Isotope Facility
CANHR Culture Intervention Core
Group Health Research Institute
Denise Boudreau*Monica Fujii
Group Health Research Institute
Denise Boudreau*Monica Fujii
Puget Sound Blood Center
John Kulman*
Puget Sound Blood Center
John Kulman*
GOALS• To develop collaborative approaches for improving the diversity of populations participating in PGx
research, particularly American Indian and Alaska Native people.
• To evaluate opportunities for PGx to benefit rural and underserved populations, which traditionally have been understudied, yet may have more to gain clinically and economically from selected PGx applications.
GOALS• To develop collaborative approaches for improving the diversity of populations participating in PGx
research, particularly American Indian and Alaska Native people.
• To evaluate opportunities for PGx to benefit rural and underserved populations, which traditionally have been understudied, yet may have more to gain clinically and economically from selected PGx applications.
* Lead Co-Investigator
U01 GM092676
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