neoplasia lab

Pathology-LabNeoplasia-127th Oct’09

Ravi A Patel

Memory++ (M++)

Villous adenoma Colon

Lipoma

Verruca vulgaris (warts) - Skin

Leiomyoma Fibro adenoma

Normal ColonTaenia coli

1.Mucosa

2.Submucosa

outerlongitudinal

inner circular

3.Tunica Muscularis Normal Rectum

While Observing the slide of Villous Adenoma

• Epithelial Polyp- (Abnormal growth of tissue from the mucous membrane)

• Generally Sessile- upto 10cm diameter,velvety, cauliflower like projections 1-3 cm above normal mucosa

• The Frondlike(large divided leaf like) villiforms are surrounded by Dyplastic,disorderly arranged columnar epithelium

• Site of Adenoma- Colon, Rectum and Rectosigmoid

Villous Adenoma Epithelial Polyp

Dysplastic Columnar Epithelium

Villous Adenoma

Branching of the glands

Scanty fibrous stroma between the glands

While observing slide of Lipoma

• Tumor• Fibrous capsule• Remnants of the lobules• Mature fat cells • Scanty Stroma

Lipoma

LPO

Mature Fat cells withScanty stroma

RemnantsOf mammaryGlandlobules

Fat cells areWithin a thin fibrous capsule

LPO

HPO

Fibrous capsule

HPO

Scanty stroma and Fat cells

While Observing the Slide of Warts

Central thickened portion----- Represents Epidermal Hyperplasia with Papillomatous formation

•Koilocytes with Halos•Underlying Dermis shows scanty lymphocyte infiltrates•Causative organism-HPV

Verruca Vulgaris Skin (Warts)

Structure at pointer:- Papillomatous formation

LPO

Structure at pointer-Koilocyte with HalosSurrounding the nuclei

HPO

Koilocytes

HPO

Koilocytes

Obvious transition representing the further central thickened portion to follow which signifies the site of Wart

LPO

Another view of centally thickened portion with Papillomatous formation

Scanty Lymphocyte infiltrates in the Dermis

While Observing the slide of Leiomyoma– A.K.A Fibroids

• In HPO- Observe the whorling of the smooth muscles of the myometrium

• Fibrosis of the stroma is found.

• Also Known as Fibroids because they are firm.

• Facts– Leiomyoma is the most common benign tumour in women and they arise from smooth muscle of myometrium. They occur during active reproductive life.In Menopause they may calcify.Estrogen stimulate their Growth.

Leiomyoma

HPO

Whorling of smooth muscles Of myometrium

HPO

Significant FibrosisLPO

While observing the slide of Fibroadenoma

• Proliferating intralobular stroma pushing the epithelium

• There are 2 types of fibroadenoma1. Pericanalicular Fibroadenoma

In this kind of Fibroadenoma the ductal space are round/oval and fairly regualar

2. Intracanalicular Fibroadenoma Over here there is extensive proliferation of

surrounding stroma which compresses the ducts giving them irregular/star shape on cross section.

Poliferating Stroma is pushing The ducts leading to their irregularShape..This signifies of the slide being Intracanalicular fibradenoma

Fibroadenoma

Thanking to the entire Universe