management of diabetic emergencies:...
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Management of
Diabetic
Emergencies:
Hypoglycaemia
2
Hypoglycaemia
Definition
• Hypoglycaemia is defined by either one of the following
two conditions:
• Low plasma glucose level (<4.0 mmol/L).
• Development of autonomic or neuroglycopenic
symptoms in patients treated with insulin or OADs which
are reversed by caloric intake.
3
Symptoms of Hypoglycaemia
Autonomic Neuroglycopenic
Trembling
Palpitations
Sweating
Anxiety
Hunger
Nausea
Tingling
Difficulty concentrating
Confusion
Weakness
Drowsiness
Vision changes
Difficulty speaking
Headache
Dizziness
Mild Autonomic symptoms are present. The
individual is able to self-treat.
Moderate Autonomic and neuroglycopenic symptoms
are present. The individual is able to self-
treat.
Severe Individual requires assistance of another
person.
May become unconscious, plasma glucose is
usually less than 2.8 mmol/L.
Severity of Hypoglycaemia
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Vicious circle of hypoglycemia awareness
Hypoglycemic events
lead
hypoglycaemic events
Frequent hypo
<4.0 mmol/l
Adapted from Hermanns et al. Diabetologie 2009; 4: R 93-R112
Symptoms of hypo
- weaker
- appear later
- change
Awareness of hypo:
- more difficult
- less reliable
Hypoglycaemic Symptoms Based on Blood Glucose Levels
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Complications and Effects of Severe Hypoglycemia
Plasma glucose level
10
20
30
40
50
60
70
80
90
100
110
1
2
3
4
5
6
mg/dL
mmol/L
1. Landstedt-Hallin L et al. J Intern Med. 1999;246:299–307. 2. Cryer PE. J Clin Invest. 2007;117(4):868–870.
Increased Risk of Cardiac
Arrhythmia1
Progressive
Neuroglycopenia2
Abnormal prolonged cardiac
repolarization—
↑ QTc and QTd
Sudden death
Cognitive impairment
Unusual behavior
Seizure
Coma
Brain death
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Lipids Online Slide Library www.lipidsonline.org
Severe Hypoglycemia Causes QTc Prolongation
P=NS
P=0.0003
Landstedt-Hallin L et al. J Intern Med. 1999;246:299–307.
Euglycemic clamp (n=8)
Hypoglycemic clamp 2 weeks after
glibenclamide withdrawal (n=13)
0
360
370
380
390
400
410
420
430
440
450
Mean
QT in
terval,
ms
Baseline (t=0)
End of clamp (t=150 min) ACCORD?
Significant QTc prolongation
during
hypoglycemia
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Lipids Online Slide Library www.lipidsonline.org
Asymptomatic Episodes of Hypoglycemia May Go Unreported
In a cohort of patients with
diabetes, more than 50%
had asymptomatic
(unrecognized)
hypoglycemia, as
identified by continuous
glucose monitoring1
Other researchers have
reported similar findings2,3
1. Copyright © 2003 American Diabetes Association. Chico A et al. Diabetes Care. 2003;26(4):1153–1157. Reprinted with permission from the American Diabetes Association.
2. Weber KK et al. Exp Clin Endocrinol Diabetes. 2007;115(8):491–494. 3. Zick R et al. Diab Technol Ther. 2007;9(6):483–492.
0
25
50
75
100
All patients
with diabetes
Type 1
diabetes
Pat
ien
ts,
%
Type 2
diabetes
55.7 62.5
46.6
Patients With ≥1 Unrecognized
Hypoglycemic Event, %
n=70 n=40 n=30
Sleep blunts the counter-regulatory catecholamine response to hypoglycaemia
Jones et al. N Engl J Med 1998;338:1657–62
Baseline was defined as mean plasma concentrations of the values at −20 and 0 min
Hypoglycemia Outcomes
VADT, ACCORD,
ADVANCE
Risk factors for hypoglycaemia:
• Advancing age
• Severe cognitive impairment
• Poor health knowledge
• Increased A1c
• Hypoglycaemia unawareness
• Long standing insulin therapy
• Renal impairment, Neuropathy
• Patients at high risk for severe hypoglycaemia should be
informed of their risk and counselled, along with their
family members and friends.
• Patients at risk of hypoglycaemia are discouraged from
driving, riding, cycling or operating heavy machineries, as
these activities may endanger oneself and the public.
Treatment of Hypoglycaemia
Treatment of SEVERE Hypoglycemia in
Unconscious Person with IV Access
1. Treat with 10-25 g (20-50 cc of D50W) of glucose
intravenously over 1-3 minutes
2. Retest in 15 minutes to ensure the BG >4.0 mmol/L
and retreat with a further 15 g of carbohydrate if
needed
3. Once conscious, eat usual snack or meal due at that
time of day or a snack with 15 g carbohydrate plus
protein
• 15 g of glucose in the form of glucose
tablets
• 15 mL (3 teaspoons) or 3 packets of sugar
dissolved in water
• 175 mL (3/4 cup) of juice or regular soft
drink
• 6 Lifesavers (1=2.5 g of carbohydrate)
• 15 mL (1 tablespoon) of honey
Examples of 15 g Simple Carbohydrate
The aims of treatment are to:
• Detect and treat a low blood glucose level promptly.
• Eliminate the risk of injury to oneself and to relieve
symptoms quickly.
• Avoid overcorrection of hypoglycaemia especially in
repeated cases as this will lead to poor glycaemic control
and weight gain.
• In severe hypoglycaemia where the individual is
still conscious:
• Ingest 20 grams of carbohydrate and the above steps
are repeated.
• In severe hypoglycaemia and unconscious
individual:
• He/she should be given IV 20–50 mL of D50% over 1-3
minutes.
• Outside the hospital setting, a tablespoon of honey
should be administered into the oral cavity
• Once hypoglycaemia has been reversed, the patient
should have the usual meal or snack that is due at that
time of the day to prevent repeated hypoglycaemia.
• Patients receiving anti-diabetic agents that may cause
hypoglycaemia should be counselled on:
• strategies for prevention,
• recognition, and
• treatment of hypoglycaemia.
• Individuals on insulin may need to have their insulin
regimen adjusted appropriately to lower their risk.
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